NO800878L - METHOD OF PREPARING HETEROCYCLIC SUBSTITUTED PYRAZINOYLGUANIDINES - Google Patents

METHOD OF PREPARING HETEROCYCLIC SUBSTITUTED PYRAZINOYLGUANIDINES

Info

Publication number
NO800878L
NO800878L NO800878A NO800878A NO800878L NO 800878 L NO800878 L NO 800878L NO 800878 A NO800878 A NO 800878A NO 800878 A NO800878 A NO 800878A NO 800878 L NO800878 L NO 800878L
Authority
NO
Norway
Prior art keywords
pyrazinoylguanidines
heterocyclic substituted
preparing heterocyclic
substituted pyrazinoylguanidines
preparing
Prior art date
Application number
NO800878A
Other languages
Norwegian (no)
Other versions
NO152560C (en
NO152560B (en
Inventor
Edward J Cragoe Jr
Otto W Woltersdorf Jr
Susan Jane Desolms
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO800878L publication Critical patent/NO800878L/en
Publication of NO152560B publication Critical patent/NO152560B/en
Publication of NO152560C publication Critical patent/NO152560C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The case involves novel heterocyclic substituted pyrazinoylguanidines and a process for preparing same. The heterocyclic pyrazinoylguanidines are eukalemic agents possessing diuretic and natriuretic properties.
NO800878A 1979-03-27 1980-03-26 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE HETEROCYCLIC SUBSTITUTED PYRAZINOYLGUANIDINES NO152560C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/024,293 US4246406A (en) 1979-03-27 1979-03-27 Heterocyclic substituted pyrazinoylguanidines

Publications (3)

Publication Number Publication Date
NO800878L true NO800878L (en) 1980-09-29
NO152560B NO152560B (en) 1985-07-08
NO152560C NO152560C (en) 1985-10-16

Family

ID=21819847

Family Applications (1)

Application Number Title Priority Date Filing Date
NO800878A NO152560C (en) 1979-03-27 1980-03-26 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE HETEROCYCLIC SUBSTITUTED PYRAZINOYLGUANIDINES

Country Status (10)

Country Link
US (1) US4246406A (en)
EP (1) EP0017152B1 (en)
JP (2) JPS55130965A (en)
AT (1) ATE2323T1 (en)
AU (1) AU533298B2 (en)
DE (1) DE3061733D1 (en)
DK (1) DK129180A (en)
IE (1) IE49578B1 (en)
NO (1) NO152560C (en)
ZA (1) ZA801770B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4496573A (en) * 1982-08-24 1985-01-29 William H. Rorer, Inc. 1-Pyridylmethyl-3-acyl guanidines
US4512991A (en) * 1982-12-27 1985-04-23 Merck & Co., Inc. 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
AU2003295402A1 (en) * 2002-11-06 2004-06-03 Bristol-Myers Squibb Company Acyl guanidine compounds and use thereof
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
JP4805824B2 (en) * 2003-08-18 2011-11-02 パリオン・サイエンシィズ・インコーポレーテッド Capped pyrazinoylguanidine sodium channel blocker
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US7399766B2 (en) * 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
PT2155721E (en) 2007-05-07 2011-05-09 Novartis Ag Organic compounds
TWI439462B (en) 2007-12-10 2014-06-01 Novartis Ag Spirocyclic guanidine compounds as enac blockers
CN102665715A (en) 2009-10-22 2012-09-12 沃泰克斯药物股份有限公司 Compositions for treatment of cystic fibrosis and other chronic diseases
AR086745A1 (en) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-DIAMINO-6-CHLORINE-N- (N- (4- (4- (2- (HEXIL (2,3,4,5,6-PENTAHYDROXIHEXIL)) AMINO) ETOXI) PHENYL) BUTIL) CARBAMIMIDOIL) PIRAZINA -2-CARBOXAMIDE
AP2015008556A0 (en) 2012-12-17 2015-06-30 Parion Sciences Inc Chloro-pyrazine carboxamide derivatives useful forthe treatment of diseases favoured by insufficien t mucosal hydration
EP2931712B8 (en) 2012-12-17 2018-05-23 Parion Sciences, Inc. 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6409714A (en) * 1962-10-30 1965-10-01
BE639386A (en) * 1962-10-30
US3328404A (en) * 1966-08-25 1967-06-27 Merck & Co Inc Derivatives of pyrazine
US3432502A (en) * 1966-08-25 1969-03-11 Merck & Co Inc Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
NL6707564A (en) * 1966-08-25 1968-02-26
US4087526A (en) * 1976-07-23 1978-05-02 Merck & Co., Inc. (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

Also Published As

Publication number Publication date
EP0017152B1 (en) 1983-01-26
DK129180A (en) 1980-09-28
EP0017152A1 (en) 1980-10-15
US4246406A (en) 1981-01-20
DE3061733D1 (en) 1983-03-03
ATE2323T1 (en) 1983-02-15
JPS56158771A (en) 1981-12-07
AU533298B2 (en) 1983-11-17
NO152560C (en) 1985-10-16
JPS55130965A (en) 1980-10-11
NO152560B (en) 1985-07-08
AU5653680A (en) 1980-10-02
ZA801770B (en) 1981-11-25
IE49578B1 (en) 1985-10-30
IE800608L (en) 1980-09-27

Similar Documents

Publication Publication Date Title
NO800878L (en) METHOD OF PREPARING HETEROCYCLIC SUBSTITUTED PYRAZINOYLGUANIDINES
AT377522B (en) METHOD FOR THE PRODUCTION OF FURO- (3,4-C) PYRIDINE DERIVATIVES
NO149324C (en) PROCEDURE FOR TREATING AN UNDERGRADUAL FORM
YU100379A (en) Process for obtaining new heterocyclic derivatives
NO792267L (en) PROCEDURE FOR MANUFACTURING SUBSTITUTED BENZAPINES
YU41608B (en) Process for obtaining new derivatives of substituted benzamides
BG35042A3 (en) Method for preparing benzodiazepinic compounds
ZA791616B (en) Process for making histamine antagonists
AR242239A1 (en) Process for the reparation of water-soluble phthalocyanine dyestuffs
GB2030440B (en) Method for the manufacture of fibrous articles
RO85323A (en) PROCESS FOR THE PREPARATION OF HETEROCYCLIC PENOXIAMINS
FI800547A (en) PROCESS FOER BEHANDLING AV VIRKE
DK129280A (en) METHOD FOR PREPARING PYRAZINE CARBOXAMIDES
BR7905983A (en) CAPACITOR AND ANODE SET FOR CAPACITOR AND ITS MANUFACTURING PROCESS
PT69645A (en) Process for the preparing of heterocyclic compounds
GB2036734B (en) Process for the production of an optionally substituted 2-mercapto-4,6-dichloro-s-triazine
NL7903062A (en) PROCESS FOR PREPARING 1,4-BIS-PIPERONYLPIPERAZINE AND ANALOGUE COMPOUNDS.
GB2024837B (en) Process for the reparation of water-soluble phthalocyanine dyestuffs
NL7902705A (en) PROCESS FOR PREPARING 2-MERCAPTOBENZOTHIAZOLE.
YU147879A (en) Process for obtaining new heterocyclic derivatives
ZA79882B (en) Method for the manufacture of matches
RO76333A2 (en) PROCESS FOR THE CONSOLIDATION OF ACVIFER NIPS
ATE3980T1 (en) PROCESS FOR THE PRODUCTION OF RIBOFLAVIN.
RO75755A2 (en) METHOD OF FONOCRIMINALISTIC EXPERTISE FOR THE IDENTIFICATION OF RADIO EMISSION-RECEPTION STATIONS
BA96067B1 (en) A process for the preparation of novel heterocyclic azole derivatives