NO20084851L - N-oxides of pyridylmethylpiperazine and -piperindine derivatives - Google Patents

N-oxides of pyridylmethylpiperazine and -piperindine derivatives

Info

Publication number
NO20084851L
NO20084851L NO20084851A NO20084851A NO20084851L NO 20084851 L NO20084851 L NO 20084851L NO 20084851 A NO20084851 A NO 20084851A NO 20084851 A NO20084851 A NO 20084851A NO 20084851 L NO20084851 L NO 20084851L
Authority
NO
Norway
Prior art keywords
nitrogen atom
oxides
preparation
disorders
ring
Prior art date
Application number
NO20084851A
Other languages
Norwegian (no)
Inventor
Marcel P M Van Aar
Jan Zorgdrager
Arnoldus H J Herremans
Peter H Van Amsterdam
Gerrit A Barf
Johan Antoine Bakker
Cathaline Den Besten
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2007/054048 external-priority patent/WO2007128694A1/en
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20084851L publication Critical patent/NO20084851L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone

Abstract

Oppfinnelsen angår N-oksider av visse pyridylmetylpiperazin og piperidinderivater som alternativer eller som "prodmg" til deres respektive morforbindelser, farmasøytiske sammensetninger som inneholder disse N-oksidene, fremgangsmåter for fremstilling av dem og fremgangsmåter for fremstilling av sammensetninger. Oppfinnelsen angår N-oksider av forbindelser som har formel (a) hvori symbolene har betydningen gitt i beskrivelsen, og hvori det oksiderte nitrogenatomet kan være nitrogenatomet i pyridylringen til R, eller nitrogenatomet i piperidinringen (når Z er karbon) eller ett av nitrogenatomene i piperazinringen (når Z er nitrogen), eller både nitrogenatomet bundet til Rvia en metylengmppe og nitrogenatomet i pyridylringen til R, og tautomerer, stereoisomerer, farmakologiske akseptable salter, hydrater og solvater derav.Oppfinnelsen angår også anvendelsene av slike N-oksider og sammensetninger, særlig for fremstilling av et medikament anvendelig for behandling av affeksjoner og sykdommer i sentralnervesystemet forårsaket av forstyrrelser i enten de dopaminergiske eller serotinenergiske systemene, for eksempel Parkinson's sykdom, aggresjon, angstforstyrrelser, autisme, vertigo, depresjon, forstyrrelser vedrørende kognisjon eller hukommelse og særlig schizofreni og andre psykotiske forstyrrelser.The invention relates to N-oxides of certain pyridylmethylpiperazine and piperidine derivatives as alternatives or as "prodmg" to their respective parent compounds, to pharmaceutical compositions containing these N-oxides, to processes for their preparation and to processes for the preparation of compositions. The invention relates to N-oxides of compounds of formula (a) in which the symbols have the meaning given in the description, and in which the oxidized nitrogen atom may be the nitrogen atom in the pyridyl ring of R, or the nitrogen atom in the piperidine ring (when Z is carbon) or one of the nitrogen atoms in the piperazine ring. (when Z is nitrogen), or both the nitrogen atom bonded to Rvia a methylene group and the nitrogen atom in the pyridyl ring of R preparation of a medicament useful for the treatment of affections and diseases of the central nervous system caused by disorders of either the dopaminergic or serotonergic systems, such as Parkinson's disease, aggression, anxiety disorders, autism, vertigo, depression, disorders of cognition or memory and especially schizophrenia disturbances .

NO20084851A 2006-05-02 2008-11-18 N-oxides of pyridylmethylpiperazine and -piperindine derivatives NO20084851L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79655106P 2006-05-02 2006-05-02
EP06113393 2006-05-02
PCT/EP2007/054048 WO2007128694A1 (en) 2006-05-02 2007-04-25 N-oxides of pyridylmethylpiperazine and -piperidine derivatives

Publications (1)

Publication Number Publication Date
NO20084851L true NO20084851L (en) 2008-11-24

Family

ID=40239755

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084851A NO20084851L (en) 2006-05-02 2008-11-18 N-oxides of pyridylmethylpiperazine and -piperindine derivatives

Country Status (3)

Country Link
KR (1) KR20090010093A (en)
IL (1) IL194758A0 (en)
NO (1) NO20084851L (en)

Also Published As

Publication number Publication date
IL194758A0 (en) 2009-08-03
KR20090010093A (en) 2009-01-28

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