NO20081713L - Pyrimidine derivatives and their use as KCNQ potassium channel openers - Google Patents

Pyrimidine derivatives and their use as KCNQ potassium channel openers

Info

Publication number
NO20081713L
NO20081713L NO20081713A NO20081713A NO20081713L NO 20081713 L NO20081713 L NO 20081713L NO 20081713 A NO20081713 A NO 20081713A NO 20081713 A NO20081713 A NO 20081713A NO 20081713 L NO20081713 L NO 20081713L
Authority
NO
Norway
Prior art keywords
pyrimidine derivatives
potassium channel
channel openers
kcnq potassium
openers
Prior art date
Application number
NO20081713A
Other languages
Norwegian (no)
Inventor
Mario Rottlander
Daniel Rodriguez Greve
Nikolay Khanzhin
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO20081713L publication Critical patent/NO20081713L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelse vedrører pyrimidinderivater med den generelle formelen I eller salter av disse og bruken av dem som åpnere av KNCQ familiens kaliumionekanaler, spesielt til behandling av epilepsi.The present invention relates to pyrimidine derivatives of the general formula I or their salts and their use as openers of the KNCQ family's potassium ion channels, in particular for the treatment of epilepsy.

NO20081713A 2005-09-09 2008-04-09 Pyrimidine derivatives and their use as KCNQ potassium channel openers NO20081713L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200501262 2005-09-09
PCT/DK2006/050039 WO2007065449A1 (en) 2005-09-09 2006-09-07 Pyrimidine derivatives and their use as kcnq potassium channels openers

Publications (1)

Publication Number Publication Date
NO20081713L true NO20081713L (en) 2008-06-04

Family

ID=37199174

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081713A NO20081713L (en) 2005-09-09 2008-04-09 Pyrimidine derivatives and their use as KCNQ potassium channel openers

Country Status (15)

Country Link
EP (1) EP1937653A1 (en)
JP (1) JP2009507052A (en)
KR (1) KR20080043314A (en)
CN (1) CN101258133A (en)
AR (1) AR055420A1 (en)
AU (1) AU2006322461A1 (en)
BR (1) BRPI0615631A2 (en)
CA (1) CA2621854A1 (en)
EA (1) EA200800780A1 (en)
IL (1) IL189545A0 (en)
MX (1) MX2008002294A (en)
NO (1) NO20081713L (en)
UA (1) UA93387C2 (en)
WO (1) WO2007065449A1 (en)
ZA (1) ZA200802174B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2694887A1 (en) * 2007-08-01 2009-02-05 Henriette Husum Bak-Jensen Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
WO2010097379A1 (en) * 2009-02-24 2010-09-02 Neurosearch A/S Substituted pyrimidin derivatives and their medical use
EP2590961A1 (en) * 2010-07-08 2013-05-15 Pfizer Inc Piperidinyl pyrimidine amides as kv7 potassium channel openers
MX367623B (en) * 2010-10-20 2019-08-29 Gruenenthal Gmbh Substituted 6-amino-nicotinamides as kcnq2/3 modulators.
CN103508960B (en) * 2012-06-29 2017-12-12 江苏先声药业有限公司 Benzheterocyclic derivatives
CN103508943B (en) * 2012-06-29 2017-06-09 江苏先声药业有限公司 As the compound of potassium channel modulating agents
EP3210969B1 (en) 2014-10-24 2021-04-28 ONO Pharmaceutical Co., Ltd. Kcnq2-5 channel activator
US20220280455A1 (en) * 2019-08-02 2022-09-08 H. Lundbeck A/S Alcohol derivatives as kv7 potassium channel openers for use in epilepsy or seizures

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002066036A1 (en) * 2001-02-20 2002-08-29 Bristol-Myers Squibb Company 2,4-disubstituted pyrimidine-5-carboxamide derivatives as kcnq potassium channel modulators
WO2003068769A1 (en) * 2002-02-12 2003-08-21 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
US20080261918A1 (en) * 2004-12-17 2008-10-23 Graham Andrew Showell Silicon Compounds and Their Use

Also Published As

Publication number Publication date
JP2009507052A (en) 2009-02-19
UA93387C2 (en) 2011-02-10
BRPI0615631A2 (en) 2011-05-24
AU2006322461A1 (en) 2007-06-14
KR20080043314A (en) 2008-05-16
ZA200802174B (en) 2009-10-28
CN101258133A (en) 2008-09-03
CA2621854A1 (en) 2007-06-14
IL189545A0 (en) 2008-06-05
AR055420A1 (en) 2007-08-22
MX2008002294A (en) 2008-03-14
EP1937653A1 (en) 2008-07-02
EA200800780A1 (en) 2008-06-30
WO2007065449A1 (en) 2007-06-14

Similar Documents

Publication Publication Date Title
NO20081713L (en) Pyrimidine derivatives and their use as KCNQ potassium channel openers
NO20071843L (en) Substituted aniline derivatives
NO20080675L (en) P38-Map kinase inhibitors and methods for their use
NO20074959L (en) Substituted pyridine derivatives
SG164368A1 (en) Treatment of cancer
NO20091509L (en) Substituted tetrahydropyrrolopyrazine compounds with affinity KCNQ2 / 3 K + channel and its use in drugs
WO2007027238A3 (en) Jak kinase inhibitors and their uses
NO20064976L (en) Azanidols useful as inhibitors of rock and other protein kinases
MX2009006195A (en) 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use.
MX2009011211A (en) 7-substituted indole mcl-1 inhibitors.
MX2009011210A (en) 7-nonsubstituted indole mcl-1 inhibitors.
SG170828A1 (en) Deazapurines useful as inhibitors of janus kinases
GEP20094785B (en) Pyrrolopyrazoles, potent kinase inhibitors
NO20071549L (en) New benzofused heteroalrylsulfamide derivatives, useful as anticonvulsants
NO20066055L (en) pyridine derivatives
NO20076054L (en) Imidiazo and triazolopyridines as inhibitors of 11-beta-hydroxysteroid dehydrogenase type I
NO20081454L (en) Met kinase inhibitors
TN2009000128A1 (en) Dihydropyridine derivatives useful as protein kinase inhibitors
WO2005110994A3 (en) Substituted pyrazolyl urea derivatives useful in the treatment of cancer
WO2007092622A3 (en) Compositions and methods for treating bone
NO20062020L (en) 1-Amino-2-Oxy-Substituted Tetrahydronaphthalene Derivatives, Methods of Preparation thereof, and Their Use as Antiflogistics
NO20090157L (en) Ten pyrimidines useful as modulators of ion channels
SI1937669T1 (en) Novel benzopyran derivatives as potassium channel openers
NO20054371L (en) Somatostatin-dopamine chimeric analogs
NO20082096L (en) Azaindole-2-karboksamidderivativer

Legal Events

Date Code Title Description
CREP Change of representative

Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104

FC2A Withdrawal, rejection or dismissal of laid open patent application