NO20080461L - Solvent of cabergoline and preparations of cobergoline form I - Google Patents

Solvent of cabergoline and preparations of cobergoline form I

Info

Publication number
NO20080461L
NO20080461L NO20080461A NO20080461A NO20080461L NO 20080461 L NO20080461 L NO 20080461L NO 20080461 A NO20080461 A NO 20080461A NO 20080461 A NO20080461 A NO 20080461A NO 20080461 L NO20080461 L NO 20080461L
Authority
NO
Norway
Prior art keywords
cabergoline
cobergoline
preparations
solvent
solvate
Prior art date
Application number
NO20080461A
Other languages
Norwegian (no)
Inventor
Parveen Bhatarah
Alan Greenwood
Derek Mchattie
Mahmoud Aloui
Original Assignee
Resolution Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolution Chemicals Ltd filed Critical Resolution Chemicals Ltd
Publication of NO20080461L publication Critical patent/NO20080461L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Abstract

Fremgangsmåte for fremstilling av kabergolin Form I, som omfatter å danne et solvat inkluderende kabergolin og et p-disubstituert benzen med formel (A) og å oppnå kabergolin Form I fra solvatet. Et annet aspekt av den foreliggende oppfinnelse tilveiebringer en fremgangsmåte for fremstilling av kabergolin Form I som omfatter å oppløse kabergolin i p-disubstituert benzen og å utvinne kabergolin Form I poly-lomorfen, passende ved direkte krystallisering av Form I eller ved utvinning av et solvat som kan omdannes til Form I.Process for the preparation of cabergoline Form I, which comprises forming a solvate including cabergoline and a p-disubstituted benzene of formula (A) and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a process for the preparation of cabergoline Form I which comprises dissolving cabergoline in p-disubstituted benzene and recovering the cabergoline Form I polylomorph, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I.

NO20080461A 2005-07-27 2008-01-24 Solvent of cabergoline and preparations of cobergoline form I NO20080461L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0515430.7A GB0515430D0 (en) 2005-07-27 2005-07-27 Preparation of cabergoline
PCT/GB2006/002784 WO2007012846A1 (en) 2005-07-27 2006-07-27 Solvate of cabergoline and preparations of cabergoline form i

Publications (1)

Publication Number Publication Date
NO20080461L true NO20080461L (en) 2008-04-18

Family

ID=34976701

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080461A NO20080461L (en) 2005-07-27 2008-01-24 Solvent of cabergoline and preparations of cobergoline form I

Country Status (10)

Country Link
EP (1) EP1912984A1 (en)
JP (1) JP2009502895A (en)
CN (1) CN101228159A (en)
AU (1) AU2006273831A1 (en)
CA (1) CA2616738A1 (en)
GB (1) GB0515430D0 (en)
IL (1) IL188598A0 (en)
NO (1) NO20080461L (en)
WO (1) WO2007012846A1 (en)
ZA (1) ZA200801151B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1925616A1 (en) * 2006-10-26 2008-05-28 LEK Pharmaceuticals D.D. Process for the preparation of crystal forms of cabergoline via stable solvates of cabergoline
CN104147041B (en) * 2014-08-17 2017-02-22 山西振东安特生物制药有限公司 Dispersion preparation containing colloidal bismuth pectin and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0007308D0 (en) * 2000-03-24 2000-05-17 Pharmacia & Upjohn Spa Process for preparing crystalline form | of cabergoline
JP2005520831A (en) * 2002-03-15 2005-07-14 ファルマシア・コーポレーション Method for producing crystalline form I of cabergoline
IL163520A0 (en) * 2002-03-15 2005-12-18 Pharmacia Italia Spa Process for preparing crystalline form i of cabergoline
CA2525104A1 (en) * 2003-05-08 2004-11-25 Ivax Pharmaceuticals S.R.O. Polymorphs of cabergoline

Also Published As

Publication number Publication date
GB0515430D0 (en) 2005-08-31
IL188598A0 (en) 2008-04-13
JP2009502895A (en) 2009-01-29
CN101228159A (en) 2008-07-23
CA2616738A1 (en) 2007-02-01
ZA200801151B (en) 2009-04-29
WO2007012846A1 (en) 2007-02-01
AU2006273831A1 (en) 2007-02-01
EP1912984A1 (en) 2008-04-23

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application