NO20072520L - Novel intermediates, process for their preparation and synthesis of 1,4-benzoquinones - Google Patents

Novel intermediates, process for their preparation and synthesis of 1,4-benzoquinones

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Publication number
NO20072520L
NO20072520L NO20072520A NO20072520A NO20072520L NO 20072520 L NO20072520 L NO 20072520L NO 20072520 A NO20072520 A NO 20072520A NO 20072520 A NO20072520 A NO 20072520A NO 20072520 L NO20072520 L NO 20072520L
Authority
NO
Norway
Prior art keywords
group
preparation
benzyl
phenyl
alkyl
Prior art date
Application number
NO20072520A
Other languages
Norwegian (no)
Inventor
Hans-Rene Bjorsvik
Original Assignee
Bergen Teknologioverforing As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bergen Teknologioverforing As filed Critical Bergen Teknologioverforing As
Priority to NO20072520A priority Critical patent/NO20072520L/en
Priority to PCT/NO2008/000172 priority patent/WO2008140328A2/en
Publication of NO20072520L publication Critical patent/NO20072520L/en

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Abstract

Det beskrives en fremgangsmåte for fremstilling av 1,4-benzoquioner av formel (II) (II) hvor R1, R2, R3og R4 er uavhengig valgt blant gruppen omfattende forgrenet eller ikke-forgrenet C1-C6, alkyl, fenyl og benzyl, hvor fenyl og benzyl er valgfritt substituert av én eller flere substituenter uavhengig valgt blant gruppen omfattende C1-C6 alkyl og halogen og hvor C1-C6, alkyl er valgfritt substituert med én eller flere halogensubstituenter, og hvor R2 og R3 sammen kan danne en C1-C6-alkylenradikal, valgfritt substituert av én eller flere substituenter uavhengig valgt blant gruppen omfattende C1-C6, benzyl, fenyl og halogen. En foretrukket forbindelse er 2,3-dimetoksy-5-metyl-[1,4]-benzoquinon, også kjent som koenzym Q0 (CoQ0). Også beskrevet er nye forbindelser og mellomprodukter, og en fremgangsmåte for fremstilling av koenzym Qn, fortrinnsvis koenzym Q0. Også beskrevet er en fremgangsmåte for kontinuerlig syntese av 1,4-benzoquioner i en kontinuerlig strømningsreaktor.There is disclosed a process for the preparation of 1,4-benzoquions of formula (II) (II) wherein R 1, R 2, R 3 and R 4 are independently selected from the group consisting of branched or unbranched C 1 -C 6, alkyl, phenyl and benzyl, wherein phenyl and benzyl is optionally substituted by one or more substituents independently selected from the group comprising C1-C6 alkyl and halogen and wherein C1-C6, alkyl is optionally substituted by one or more halogen substituents, and wherein R2 and R3 may together form a C1-C6 group. alkylene radical, optionally substituted by one or more substituents independently selected from the group comprising C1-C6, benzyl, phenyl and halogen. A preferred compound is 2,3-dimethoxy-5-methyl- [1,4] -benzoquinone, also known as coenzyme Q0 (CoQ0). Also disclosed are novel compounds and intermediates, and a process for producing coenzyme Qn, preferably coenzyme Q0. Also described is a process for the continuous synthesis of 1,4-benzoquions in a continuous flow reactor.

NO20072520A 2007-05-16 2007-05-16 Novel intermediates, process for their preparation and synthesis of 1,4-benzoquinones NO20072520L (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
NO20072520A NO20072520L (en) 2007-05-16 2007-05-16 Novel intermediates, process for their preparation and synthesis of 1,4-benzoquinones
PCT/NO2008/000172 WO2008140328A2 (en) 2007-05-16 2008-05-16 Novel intermediates, process for their preparation and synthesis of 1,4-benzoquinones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO20072520A NO20072520L (en) 2007-05-16 2007-05-16 Novel intermediates, process for their preparation and synthesis of 1,4-benzoquinones

Publications (1)

Publication Number Publication Date
NO20072520L true NO20072520L (en) 2008-11-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072520A NO20072520L (en) 2007-05-16 2007-05-16 Novel intermediates, process for their preparation and synthesis of 1,4-benzoquinones

Country Status (1)

Country Link
NO (1) NO20072520L (en)

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