NO20061954L - Transgenic animals with severe disorders related to Alzheimer's disease - Google Patents

Transgenic animals with severe disorders related to Alzheimer's disease

Info

Publication number
NO20061954L
NO20061954L NO20061954A NO20061954A NO20061954L NO 20061954 L NO20061954 L NO 20061954L NO 20061954 A NO20061954 A NO 20061954A NO 20061954 A NO20061954 A NO 20061954A NO 20061954 L NO20061954 L NO 20061954L
Authority
NO
Norway
Prior art keywords
alzheimer
disease
transgenic animals
disorders related
severe disorders
Prior art date
Application number
NO20061954A
Other languages
Norwegian (no)
Other versions
NO334611B1 (en
Inventor
Patrick Benoit
Laurent Pradier
Veronique Blanchard-Bregeon
Caty Casas Louzao
Gunter Tremp
Jean-Michel Itier
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20061954L publication Critical patent/NO20061954L/en
Publication of NO334611B1 publication Critical patent/NO334611B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to non-human transgenic animals with serious disorders related to Alzheimer's disease. The animals can be used for the discovery of compounds for the treatment of Alzheimer's disease.
NO20061954A 2003-10-02 2006-05-02 Transgenic non-human animal with a nucleic acid sequence encoding presenilin 1 protein, cell or cell line derived from the animal, mutant mouse PS1 protein, nucleic acid encoding the protein, vector comprising the nucleic acid, use of the transgenic animal to detect compounds for the treatment of Alzheimer's disease as well as methods for detecting the compounds NO334611B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0311578A FR2860391B1 (en) 2003-10-02 2003-10-02 TRANSGENIC ANIMALS WITH MAJOR DISORDERS RELATED TO ALZHEIMER'S DISEASE
PCT/FR2004/002436 WO2005032244A1 (en) 2003-10-02 2004-09-27 Transgenic animals with serious disorders related to alzheimer's disease

Publications (2)

Publication Number Publication Date
NO20061954L true NO20061954L (en) 2006-06-26
NO334611B1 NO334611B1 (en) 2014-04-22

Family

ID=34307379

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061954A NO334611B1 (en) 2003-10-02 2006-05-02 Transgenic non-human animal with a nucleic acid sequence encoding presenilin 1 protein, cell or cell line derived from the animal, mutant mouse PS1 protein, nucleic acid encoding the protein, vector comprising the nucleic acid, use of the transgenic animal to detect compounds for the treatment of Alzheimer's disease as well as methods for detecting the compounds

Country Status (22)

Country Link
EP (1) EP1670309B1 (en)
JP (1) JP4806635B2 (en)
KR (1) KR101164691B1 (en)
CN (1) CN1889826A (en)
AT (1) ATE471661T1 (en)
AU (1) AU2004277357B2 (en)
BR (1) BRPI0415032A (en)
CA (1) CA2540622C (en)
CY (1) CY1110788T1 (en)
DE (1) DE602004027823D1 (en)
DK (1) DK1670309T3 (en)
ES (1) ES2347961T3 (en)
FR (1) FR2860391B1 (en)
IL (1) IL174726A (en)
MX (2) MXPA06003685A (en)
NO (1) NO334611B1 (en)
PL (1) PL1670309T3 (en)
PT (1) PT1670309E (en)
RU (1) RU2373707C2 (en)
SI (1) SI1670309T1 (en)
WO (1) WO2005032244A1 (en)
ZA (1) ZA200602670B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2963791B1 (en) * 2010-08-11 2012-09-21 Assist Publ Hopitaux De Paris METHOD OF DIAGNOSING NEURODEGENERATIVE DISEASES
WO2014007367A1 (en) * 2012-07-05 2014-01-09 国立大学法人東京大学 Method for detecting or assaying two kinds of substances in same sample
JP6583011B2 (en) * 2016-01-20 2019-10-02 コニカミノルタ株式会社 Method for washing immunostained slides using acidic aqueous solution
CN109776665B (en) * 2019-02-02 2021-02-05 首都医科大学宣武医院 New mutation of Alzheimer disease, stable cell transfer model and medical application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003509071A (en) * 1999-09-17 2003-03-11 アバンテイス・フアルマ・エス・アー A novel animal model of Alzheimer's disease showing amyloid plaques and mitochondrial dysfunction
FR2798556B1 (en) * 1999-09-17 2004-02-27 Aventis Pharma Sa NEW ANIMAL MODEL OF ALZHEIMER'S DISEASE WITH BOTH AMYLOID PLATES AND MITOCHONDRIAL MALFUNCTIONS
DE60044205D1 (en) * 1999-09-27 2010-05-27 Aventis Pharma Sa TRANSGENE ANIMAL EXPRESSING A MULTIPLE-MUTED PRESENILIN-1
EP1304922A2 (en) * 2000-07-20 2003-05-02 Cephalon, Inc. Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring

Also Published As

Publication number Publication date
AU2004277357A1 (en) 2005-04-14
FR2860391A1 (en) 2005-04-08
ZA200602670B (en) 2007-07-25
CA2540622A1 (en) 2005-04-14
ES2347961T3 (en) 2010-11-26
AU2004277357B2 (en) 2011-11-03
IL174726A (en) 2013-05-30
PL1670309T3 (en) 2010-11-30
BRPI0415032A (en) 2006-12-12
DE602004027823D1 (en) 2010-08-05
RU2373707C2 (en) 2009-11-27
EP1670309A1 (en) 2006-06-21
EP1670309B1 (en) 2010-06-23
JP2007507217A (en) 2007-03-29
MXPA06003670A (en) 2006-06-20
KR20060090988A (en) 2006-08-17
KR101164691B1 (en) 2012-07-11
SI1670309T1 (en) 2010-11-30
ATE471661T1 (en) 2010-07-15
PT1670309E (en) 2010-09-28
RU2006114692A (en) 2007-11-10
FR2860391B1 (en) 2006-01-27
NO334611B1 (en) 2014-04-22
CN1889826A (en) 2007-01-03
IL174726A0 (en) 2006-08-20
CA2540622C (en) 2014-01-14
JP4806635B2 (en) 2011-11-02
CY1110788T1 (en) 2015-06-10
MXPA06003685A (en) 2006-06-20
DK1670309T3 (en) 2010-10-25
WO2005032244A1 (en) 2005-04-14

Similar Documents

Publication Publication Date Title
DK1874282T3 (en) Methods and Preparations for the Treatment of CNS Disorders
SE0202241D0 (en) Novel Compounds
CY1109104T1 (en) 1,2,3,4 TETRA-SUBSTITUTE INDOLOGY FOR TREATMENT OF RESPIRATORY DISEASES
EA200802054A1 (en) ENZYME INHIBITORS
MA33975B1 (en) COMPOUNDS AND METHODS FOR MODULATING KINASES AND THEIR INDICATIONS FOR USE
DK2527315T3 (en) Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes and Parkinson's disease
EP1740559A4 (en) 1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
NO20026199D0 (en) Compounds for the treatment of Alzheimer's disease
SE0303180D0 (en) Novel compounds
NO345046B1 (en) Oral dosage form
ATE529427T1 (en) Ä1H-INDOL-5-YL)-HETEROARYLOXYÜ-(1-AZA-BICYCLO-Ä3.3.1Ü-NONANES AS CHOLINERGIC LIGANDS OF THE N-ACHR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISEASES
ATE504580T1 (en) MALONIC ACID AMIDE DERIVATIVES AS INHIBITORS OF G-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE
ATE449776T1 (en) PYRROLOÄ2,3-CÜPYRIDINE DERIVATIVES
DK1315506T3 (en) Phospholipid derivatives of valproic acid and mixtures thereof
EA200600071A1 (en) Derivatives of N-phenylpyrazine and Methods for the Prevention or Treatment of Diseases Associated with 5HT-Receptor
ATE298568T1 (en) ALBUMIN-BINDING COMPOUNDS THAT PREVENT NON-ENZYMATIC GLYCOSYLATION AND WHICH CAN BE USED TO TREAT GLYCOSYLATION-RELATED DISEASES
DE602006014022D1 (en) 5-SUBSTITUTED INDOL-2-CARBOXYL ACID AMID DERIVATIVES
NO20061954L (en) Transgenic animals with severe disorders related to Alzheimer's disease
ATE541923T1 (en) TRANSGENIC C. ELEGANS AS A MODEL ORGANISM FOR STUDIES ON ALZHEIMER'S DISEASE
TW200505409A (en) Methods of inhibiting neurodegenerative disease
DE602005014632D1 (en) PYRROL-BZW. IMIDAZOLAMIDE FOR THE TREATMENT OF OBESITAS
DE602005008417D1 (en) PYRAZOLAMINE COMPOUNDS FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
EA201070495A1 (en) Γ-SECRETASE ACTIVITY MODULATORS FROM PIPERIDINYL AND PIPERASININIL GROUP
EA200701584A1 (en) ORGANIC COMPOUNDS APPLICABLE FOR THE TREATMENT OF ALZHEIMER'S DISEASE, THEIR APPLICATION AND METHOD OF OBTAINING
EA201070496A1 (en) CARBON-ASSOCIATED γ-SECRETASE MODULATORS

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees