NO20061836L - Hexa and octahydro-pyndo [1,2-a] pyrazinylates with NK1 antagonistic activity - Google Patents

Hexa and octahydro-pyndo [1,2-a] pyrazinylates with NK1 antagonistic activity

Info

Publication number
NO20061836L
NO20061836L NO20061836A NO20061836A NO20061836L NO 20061836 L NO20061836 L NO 20061836L NO 20061836 A NO20061836 A NO 20061836A NO 20061836 A NO20061836 A NO 20061836A NO 20061836 L NO20061836 L NO 20061836L
Authority
NO
Norway
Prior art keywords
compounds
antagonistic activity
pyrazinylates
pyndo
octahydro
Prior art date
Application number
NO20061836A
Other languages
Norwegian (no)
Inventor
Gustaaf Johan M Van Scharrenburg
Andrew C Mccreary
Wouter I Iwema Bakker
Adrianus Van Den Hoogenband
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2004/052277 external-priority patent/WO2005030214A1/en
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of NO20061836L publication Critical patent/NO20061836L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives heksahydro-pyrido[l,2-a]pyrazinderivater med interessant neurokinin-NKj reseptorantagonistisk aktivitet. der symbolene har de betydninger som er gitt i beskrivelsen. Det beskrives videre fremgangsmåter for fremstilling av disse forbindelser, farmasøytiske preparater inneholdende en farmakologisk aktiv mengde av minst en av disse forbindelser som aktiv bestanddel, og videre anvendelsen av disse forbindelser for for behandling av forstyrrelser der neurokininreseptorer er involvert. Oppfinnelsen angår også forbindelser representert ved den generelle formel (1)Hexahydro-pyrido [1,2-a] pyrazine derivatives with interesting neurokinin-NK 2 receptor antagonistic activity are described. where the symbols have the meanings given in the description. Methods are further described for the preparation of these compounds, pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as active ingredient, and further the use of these compounds for the treatment of disorders involving neurokinin receptors. The invention also relates to compounds represented by the general formula (1)

NO20061836A 2003-09-26 2006-04-26 Hexa and octahydro-pyndo [1,2-a] pyrazinylates with NK1 antagonistic activity NO20061836L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50587303P 2003-09-26 2003-09-26
EP03103566 2003-09-26
PCT/EP2004/052277 WO2005030214A1 (en) 2003-09-26 2004-09-23 HEXA- AND OCTAHYDRO-PYRIDO[1,2-a]PYRAZINE DERIVATIVES WITH NK1 ANTAGONISTIC ACTIVITY

Publications (1)

Publication Number Publication Date
NO20061836L true NO20061836L (en) 2006-06-23

Family

ID=34395290

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061836A NO20061836L (en) 2003-09-26 2006-04-26 Hexa and octahydro-pyndo [1,2-a] pyrazinylates with NK1 antagonistic activity

Country Status (4)

Country Link
KR (1) KR20060101474A (en)
DE (1) DE602004022562D1 (en)
IL (1) IL173964A0 (en)
NO (1) NO20061836L (en)

Also Published As

Publication number Publication date
DE602004022562D1 (en) 2009-09-24
IL173964A0 (en) 2006-07-05
KR20060101474A (en) 2006-09-25

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application