NO20061350L - Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation - Google Patents

Process for Enantioselective Synthesis of Single Enantiomers of Modafinil by Asymmetric Oxidation

Info

Publication number
NO20061350L
NO20061350L NO20061350A NO20061350A NO20061350L NO 20061350 L NO20061350 L NO 20061350L NO 20061350 A NO20061350 A NO 20061350A NO 20061350 A NO20061350 A NO 20061350A NO 20061350 L NO20061350 L NO 20061350L
Authority
NO
Norway
Prior art keywords
modafinil
single enantiomers
enantioselective synthesis
formula
asymmetric oxidation
Prior art date
Application number
NO20061350A
Other languages
Norwegian (no)
Other versions
NO335815B1 (en
Inventor
Gerard Duret
Francois Rebiere
Laurence Prat
Original Assignee
Cephalon France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03292312A external-priority patent/EP1516869A1/en
Application filed by Cephalon France filed Critical Cephalon France
Publication of NO20061350L publication Critical patent/NO20061350L/en
Publication of NO335815B1 publication Critical patent/NO335815B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

Oppfinnelsen omhandler en fremgangsmåte for fremstilling av en sulfoksidforbindelse med formel (I) enten som en enkeltenantiomer eller i en enantiomert anriket form, som omfatter trinnene av å: a) kontakte et pro-chiralt sulfid med formel (II) med et metall chiralt kompleks, en base og et oksidasjonsmiddel i et organisk løsemiddel; og eventuelt b) isolere det oppnådde sulfoksid med formel (I), hvori n, Y, R1, R1a. R2 og R2a er som definert i krav 1.The invention relates to a process for the preparation of a sulfoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a prochiral sulfide of formula (II) with a metal chiral complex; a base and an oxidizing agent in an organic solvent; and optionally b) isolating the sulfoxide obtained of formula (I) wherein n, Y, R1, R1a. R2 and R2a are as defined in claim 1.

NO20061350A 2003-09-19 2006-03-24 Process for preparing a sulfoxide compound NO335815B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03292312A EP1516869A1 (en) 2003-09-19 2003-09-19 Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US50708903P 2003-10-01 2003-10-01
PCT/IB2004/003026 WO2005028428A1 (en) 2003-09-19 2004-09-17 Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

Publications (2)

Publication Number Publication Date
NO20061350L true NO20061350L (en) 2006-04-05
NO335815B1 NO335815B1 (en) 2015-02-23

Family

ID=34379393

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061350A NO335815B1 (en) 2003-09-19 2006-03-24 Process for preparing a sulfoxide compound

Country Status (6)

Country Link
CY (1) CY1107734T1 (en)
HK (1) HK1084381A1 (en)
HR (1) HRP20070331T3 (en)
IL (1) IL174153A (en)
IS (1) IS2466B (en)
NO (1) NO335815B1 (en)

Also Published As

Publication number Publication date
CY1107734T1 (en) 2013-04-18
IS2466B (en) 2008-11-15
IL174153A (en) 2011-01-31
IS8411A (en) 2006-04-12
HK1084381A1 (en) 2006-07-28
NO335815B1 (en) 2015-02-23
IL174153A0 (en) 2006-08-01
HRP20070331T3 (en) 2007-09-30

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