NO20060190L - <n-pyrrolidin-3-ylamide derivatives as serotonin and norepinephrine reuptake inhibitors - Google Patents

<n-pyrrolidin-3-ylamide derivatives as serotonin and norepinephrine reuptake inhibitors

Info

Publication number
NO20060190L
NO20060190L NO20060190A NO20060190A NO20060190L NO 20060190 L NO20060190 L NO 20060190L NO 20060190 A NO20060190 A NO 20060190A NO 20060190 A NO20060190 A NO 20060190A NO 20060190 L NO20060190 L NO 20060190L
Authority
NO
Norway
Prior art keywords
alkyl
alkoxy
aryl
het
cycloalkyl
Prior art date
Application number
NO20060190A
Other languages
Norwegian (no)
Inventor
Alan Stobie
Michael Jonathan Fray
Paul Vincent Fish
Gavin Alistair Whitlock
Deborah Jane Lovering
Florian Wakenhut
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27636730&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20060190(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/IB2004/001943 external-priority patent/WO2004110995A1/en
Application filed by Pfizer filed Critical Pfizer
Publication of NO20060190L publication Critical patent/NO20060190L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Abstract

Forbindelse med formel (I) og farmasøytisk og/eller veterinærakseptable derivater derav, hvori R' er H, Ci-ealkyl, -C(X)Y, C3.«cykloalkyl, atyl, het, atyl-Ci.4alkyl, eller het-Ci.4alkyl, hvori cykloalkyl, aryl eller hetgmppene er eventuelt substituert med minst en substituent uavhengig valgt fra Ci.8allyl, Ci.8alkoksy, OH, halo, CF3, OCF3, SCF3, hydroksy-Ci.6alkyl, Ci-4alkoksy-Ci.6alkyl og Ci.4alkyl-S-Ci.4alkyl; R^ er atyl eller heteroaryl, hver eventuelt substituert med minst en subtituent uavhengig valgt fra Ci.galkyl, Ci.galkoksy, OH, halo, CF3, OCF3, SCF3, hydroksy-Ci-ealkyl, Ci.4.alkoksy-Ci.6alkyl og Ci.4alkyl-S-Ci.4alkyl; R^ er Ci-ealkyl, C3.8cykloalkyl,C3-8cykloalkyl-Ci.6alkyl, aryl, het, aiyl-Ci.4alkyl, eller het-Ci.4alkyl, hvori cykloalkyl, aryl eller hetgmppene er eventuelt substituert med minst en substituent uavhengig valgt fra Ci-ealkyl, Cuealkoksy, OH, halo, CF3, OCF3, SCF3, hydroksy-Ci.6alkyl,C i.4alkoksy-Ci.6alkyl og Ci.4alkyl-S-Ci.4alkyl; X er S eller O; Y er H, Ci.6alkyl, Ci.6alkoksy, aryl, het, aryl-Ci.4alkyl eller het-Ci.4alkyl; n er 1 eller 2, fomtsatt at når n er 1, er m 0 eller 2 og n er 2, er m 0, hvori hvis m er 0, da representerer * et kiralt senter. Forbindelsene ifølge oppfinnelsen fremviser aktivitet som både serotonin og noradrenalingjenopptagningsinhibitorer og har derfor anvendelse innenfor et antall terapeutiske områder, for eksempel urininkontinens.A compound of formula (I) and pharmaceutically and / or veterinarily acceptable derivatives thereof wherein R 1 is H, C 1-6 alkyl, -C (X) Y, C 3-6 cycloalkyl, atyl, het, atyl-C 1-4 alkyl, or hetero- C 1-4 alkyl, wherein the cycloalkyl, aryl or het group is optionally substituted with at least one substituent independently selected from C 1-8 allyl, C 1-8 alkoxy, OH, halo, CF 3, OCF 3, SCF 3, hydroxy-C 1-6 alkyl, C 1-4 alkoxy-C 1. 6alkyl and C1-4alkyl-S-C1-4alkyl; R 1 is atyl or heteroaryl, each optionally substituted with at least one subtituent independently selected from C 1-6 alkyl, C 1-4 alkoxy, OH, halo, CF 3, OCF 3, SCF 3, hydroxy-C 1-6 alkyl, C 1-4 alkoxy-C 1-6 alkyl and C 1-4 alkyl-S-C 1-4 alkyl; R 1 is C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl C 1-6 alkyl, aryl, het, aryl-C 1-4 alkyl, or het-C 1-4 alkyl, wherein the cycloalkyl, aryl or hete groups are optionally substituted with at least one substituent independently selected from C 1-6 alkyl, Cualkoxy, OH, halo, CF 3, OCF 3, SCF 3, hydroxy-C 1-6 alkyl, C 1-4 alkoxy-C 1-6 alkyl and C 1-4 alkyl-S-C 1-4 alkyl; X is S or O; Y is H, C 1-6 alkyl, C 1-6 alkoxy, aryl, het, aryl-C 1-4 alkyl or het-C 1-4 alkyl; n is 1 or 2, assuming that when n is 1, m is 0 or 2 and n is 2, m is 0, wherein if m is 0, then * represents a chiral center. The compounds of the invention exhibit activity as both serotonin and norepinephrine reuptake inhibitors and therefore have utility in a number of therapeutic areas, for example urinary incontinence.

NO20060190A 2003-06-17 2006-01-12 <n-pyrrolidin-3-ylamide derivatives as serotonin and norepinephrine reuptake inhibitors NO20060190L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0314048.0A GB0314048D0 (en) 2003-06-17 2003-06-17 Novel compounds
PCT/IB2004/001943 WO2004110995A1 (en) 2003-06-17 2004-06-07 N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors

Publications (1)

Publication Number Publication Date
NO20060190L true NO20060190L (en) 2006-01-12

Family

ID=27636730

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060190A NO20060190L (en) 2003-06-17 2006-01-12 <n-pyrrolidin-3-ylamide derivatives as serotonin and norepinephrine reuptake inhibitors

Country Status (9)

Country Link
CN (1) CN1835921A (en)
GB (1) GB0314048D0 (en)
GT (1) GT200400121A (en)
NO (1) NO20060190L (en)
OA (1) OA13178A (en)
RS (1) RS20050924A (en)
TN (1) TNSN05321A1 (en)
UA (1) UA80338C2 (en)
ZA (1) ZA200509132B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0821142A2 (en) * 2007-12-19 2015-09-15 Dainippon Sumitomo Pharma Co bicyclic heterocyclic derivatives

Also Published As

Publication number Publication date
RS20050924A (en) 2008-04-04
OA13178A (en) 2006-12-13
GT200400121A (en) 2005-03-03
UA80338C2 (en) 2007-09-10
ZA200509132B (en) 2007-02-28
GB0314048D0 (en) 2003-07-23
TNSN05321A1 (en) 2007-07-10
CN1835921A (en) 2006-09-20

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