NO20055332L - Process for the preparation of 4,10? - diacetoxy-2a benzoyloxy-5 ?, 20-epoxy-1,13a-dihydroxy-9-oxo-19-norcyclopropa [G] tax-11-ene - Google Patents

Process for the preparation of 4,10? - diacetoxy-2a benzoyloxy-5 ?, 20-epoxy-1,13a-dihydroxy-9-oxo-19-norcyclopropa [G] tax-11-ene

Info

Publication number
NO20055332L
NO20055332L NO20055332A NO20055332A NO20055332L NO 20055332 L NO20055332 L NO 20055332L NO 20055332 A NO20055332 A NO 20055332A NO 20055332 A NO20055332 A NO 20055332A NO 20055332 L NO20055332 L NO 20055332L
Authority
NO
Norway
Prior art keywords
benzoyloxy
dihydroxy
oxo
epoxy
norcyclopropa
Prior art date
Application number
NO20055332A
Other languages
Norwegian (no)
Other versions
NO331813B1 (en
Inventor
Eric Didier
Guy Amouret
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of NO20055332L publication Critical patent/NO20055332L/en
Publication of NO331813B1 publication Critical patent/NO331813B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Oppfinnelsen angår en fremgangsmåte for fremstilling av 4,10p -diacetoksy-2a benzoyloksy-5p,20- epoksy-l,13a-dihydroksy-9-okso-19-norcyklopropa[g]taks-ll-en fra 4-acetoksy-2a benzoyloksy-5p,20- epoksy-l,13a-dihydroksy-9-okso-7P-trifluormetyisulfonyloksy-taks-l l-en ved reaksjon med en molekylsikt i sulfolan.The invention relates to a process for the preparation of 4,10β-diacetoxy-2a benzoyloxy-5β, 20-epoxy-1,3a-dihydroxy-9-oxo-19-norcyclopropa [g] tax-11-ene from 4-acetoxy-2a benzoyloxy -5β, 20-epoxy-1,3a-dihydroxy-9-oxo-7β-trifluoromethylisulfonyloxy-taxa-1-one by reaction with a molecular sieve in sulfolane.

NO20055332A 2003-04-14 2005-11-11 Process for Preparation of 4,10beta-diacetoxy-2alpha-benzoyloxy-5beta, 20-epoxy-1,13alpha-dihydroxy-9-oxo-19-norcyclopropa [G] tax-11-one and process of preparing an intermediate. NO331813B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0304613A FR2853651B1 (en) 2003-04-14 2003-04-14 PROCESS FOR THE PREPARATION OF 4,10 BETA-DIACETOXY-2 ALPHA-BENZOYLOXY-5 BETA, 20-EPOXY-1, 13 ALPHA-DIHYDROXY-9-OXO-19-NORCYCLOPROPA [G] TAX-11-ENE
PCT/FR2004/000901 WO2004092151A1 (en) 2003-04-14 2004-04-13 METHOD FOR PRODUCTION OF 4,10β-DIACETOXY-2$G(A)-BENZOYLOXY-5$G(B),20-EPOXY-1,13$G(A)-DIHYDROXY-9-OXO-19-NORCYCLOPROPA[G]TAX-11-ENE

Publications (2)

Publication Number Publication Date
NO20055332L true NO20055332L (en) 2005-11-11
NO331813B1 NO331813B1 (en) 2012-04-10

Family

ID=33041834

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20055332A NO331813B1 (en) 2003-04-14 2005-11-11 Process for Preparation of 4,10beta-diacetoxy-2alpha-benzoyloxy-5beta, 20-epoxy-1,13alpha-dihydroxy-9-oxo-19-norcyclopropa [G] tax-11-one and process of preparing an intermediate.

Country Status (26)

Country Link
EP (1) EP1615902B1 (en)
JP (1) JP4664903B2 (en)
KR (1) KR101117512B1 (en)
CN (1) CN1317271C (en)
AR (1) AR043986A1 (en)
AT (1) ATE386733T1 (en)
AU (1) AU2004230302B8 (en)
BR (1) BRPI0409332A (en)
CA (1) CA2522482C (en)
CO (1) CO5700730A2 (en)
CY (1) CY1110375T1 (en)
DE (1) DE602004011917T2 (en)
DK (1) DK1615902T3 (en)
ES (1) ES2302008T3 (en)
FR (1) FR2853651B1 (en)
HK (1) HK1088306A1 (en)
IL (1) IL171318A (en)
MX (1) MXPA05010990A (en)
NO (1) NO331813B1 (en)
NZ (1) NZ543014A (en)
PL (1) PL1615902T3 (en)
PT (1) PT1615902E (en)
RU (1) RU2341520C2 (en)
TW (1) TWI360545B (en)
WO (1) WO2004092151A1 (en)
ZA (1) ZA200508209B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814658A (en) * 1992-12-09 1998-09-29 Rhone-Poulenc Rorer S.A. Taxoids, their preparation and pharmaceutical compositions containing them
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
FR2721023B1 (en) * 1994-06-09 1996-07-12 Rhone Poulenc Rorer Sa New Taxoids, their preparation and the pharmaceutical compositions containing them.
FR2726272B1 (en) * 1994-10-26 1996-12-06 Rhone Poulenc Rorer Sa NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2732968B1 (en) * 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
RU2005135137A (en) 2006-03-10
IL171318A (en) 2010-06-30
PL1615902T3 (en) 2008-07-31
ZA200508209B (en) 2007-02-28
DE602004011917D1 (en) 2008-04-03
RU2341520C2 (en) 2008-12-20
JP4664903B2 (en) 2011-04-06
WO2004092151A1 (en) 2004-10-28
FR2853651B1 (en) 2005-05-20
DE602004011917T2 (en) 2009-03-05
AU2004230302B8 (en) 2010-05-27
ATE386733T1 (en) 2008-03-15
KR20050115948A (en) 2005-12-08
DK1615902T3 (en) 2008-06-16
EP1615902A1 (en) 2006-01-18
ES2302008T3 (en) 2008-07-01
CN1774430A (en) 2006-05-17
NZ543014A (en) 2008-12-24
PT1615902E (en) 2008-05-13
AR043986A1 (en) 2005-08-17
CN1317271C (en) 2007-05-23
AU2004230302A1 (en) 2004-10-28
TW200504041A (en) 2005-02-01
CA2522482C (en) 2011-08-09
CY1110375T1 (en) 2015-04-29
CA2522482A1 (en) 2004-10-28
KR101117512B1 (en) 2012-03-15
BRPI0409332A (en) 2006-04-25
HK1088306A1 (en) 2006-11-03
NO331813B1 (en) 2012-04-10
JP2006522781A (en) 2006-10-05
TWI360545B (en) 2012-03-21
CO5700730A2 (en) 2006-11-30
FR2853651A1 (en) 2004-10-15
AU2004230302B2 (en) 2010-01-07
MXPA05010990A (en) 2005-12-12
EP1615902B1 (en) 2008-02-20

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