NO20052124L - New 1,4-diazabicycloalkane derivatives, their preparation and use - Google Patents

New 1,4-diazabicycloalkane derivatives, their preparation and use

Info

Publication number
NO20052124L
NO20052124L NO20052124A NO20052124A NO20052124L NO 20052124 L NO20052124 L NO 20052124L NO 20052124 A NO20052124 A NO 20052124A NO 20052124 A NO20052124 A NO 20052124A NO 20052124 L NO20052124 L NO 20052124L
Authority
NO
Norway
Prior art keywords
disorders
enantiomers
compounds
nervous system
disease
Prior art date
Application number
NO20052124A
Other languages
Norwegian (no)
Other versions
NO20052124D0 (en
Inventor
Gunnar M Olsen
Dan Peters
Elsebet Ostergaard Nielsen
Philip K Ahring
Tino Dyhring Jorgensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2003/000639 external-priority patent/WO2004029053A1/en
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of NO20052124D0 publication Critical patent/NO20052124D0/en
Publication of NO20052124L publication Critical patent/NO20052124L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Denne oppfinnelsen vedrører nye 1,l-diazabisykloalkanderivater med formel (I) a:K (I) hvilken som helst av dets enantio- merer eller hvilken som helst blanding av dets enantiomerer, eller et farmaseytisk akseptabelt addisjonssalt derav, eller et M- oksid derav, og deres anvendelse ved fremstillingen av farmasøytiske preparater. Forbindelsene ifølge oppfinnelsen er funnet å være kol- inerge ligander i nikocinacetyl- kolinreseptorene oq modulatorene for monoaminreseptorene og -trans- portørene. På grunn av deres farma- kologiske profil kan forbindelsene ifolge oppfinnelsen være anvendbare til behandlingen av så forskjellige sykdorraner eller forstyrrelser som de som er relatert til det kolin- erge system i sentralnervesystemet (CNS), det perifere nervesystem (PMS), sykdcm.mer eller forstyrr- elser relatert til glattratisk^ilkon- traksjon, endokrine sykdommer eller forstyrrelser, sykdommer eller for- styrrelser relatert til nevro-This invention relates to novel 1,1-diazabicycloalkane derivatives of formula (I) a: K (I) any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable addition salt thereof, or an M-oxide thereof. and their use in the manufacture of pharmaceutical compositions. The compounds of the invention have been found to be cholinergic ligands in the nicocinacetylcholine receptors and modulators of the monoamine receptors and transporters. Because of their pharmacological profile, the compounds of the invention may be useful in the treatment of as diverse disease disorders or disorders as those related to the central nervous system (CNS) cholinergic system, the peripheral nervous system (PMS), the disease or the like. disorders related to smooth muscle contraction, endocrine disorders or disorders, neurological disorders or disorders

NO20052124A 2002-09-30 2005-04-29 New 1,4-diazabicycloalkane derivatives, their preparation and use NO20052124L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200201456 2002-09-30
DKPA200201738 2002-11-11
PCT/DK2003/000639 WO2004029053A1 (en) 2002-09-30 2003-09-29 Novel 1,4-diazabicycloalkane derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
NO20052124D0 NO20052124D0 (en) 2005-04-29
NO20052124L true NO20052124L (en) 2005-06-29

Family

ID=34828377

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052124A NO20052124L (en) 2002-09-30 2005-04-29 New 1,4-diazabicycloalkane derivatives, their preparation and use

Country Status (12)

Country Link
JP (1) JP4711391B2 (en)
KR (1) KR20050062575A (en)
CN (1) CN1326857C (en)
BR (1) BR0314183A (en)
HK (1) HK1081954A1 (en)
IL (1) IL166821A (en)
IS (1) IS7829A (en)
MX (1) MXPA05003344A (en)
NO (1) NO20052124L (en)
PT (1) PT1551835E (en)
RU (1) RU2323218C2 (en)
SI (1) SI1551835T1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3019B1 (en) * 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-Triazoles
ATE518862T1 (en) * 2006-05-30 2011-08-15 Neurosearch As NEW 1,4-DIAZA-BICYCLOÄ3.2.2ÜNONYL-OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
CL2008000474A1 (en) * 2007-02-15 2008-08-22 Argenta Discovery Ltd COMPOUNDS DERIVED FROM AZONIA-BICICLO- [2.2.2] OCTANO, M3 RECEIVER MODULATORS; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DISEASES SUCH AS COPD, ASTHMA, IRRITABLE INTESTINE SYNDROME, AMONG OTHERS.
US9187451B2 (en) 2011-11-18 2015-11-17 Heptares Therapeutics Limited Muscarinic M1 receptor agonists
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
ES2879995T3 (en) * 2015-12-10 2021-11-23 Ptc Therapeutics Inc Methods for treating Huntington's disease
CN108623530B (en) * 2016-09-18 2021-05-11 广西师范大学 1,2, 8-oxo-diazacyclononane-9-thioketone derivative and synthetic method and application thereof
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US5478939A (en) * 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (en) * 1998-12-04 2001-01-19 Synthelabo NONANE 1,4-DIAZABICYCLO [3.2.2.] DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
IL147505A0 (en) * 1999-07-09 2002-08-14 Ortho Mcneil Pharm Inc Neurotrophic pyrrolidines and piperidines, and related compositions and methods
FR2804430B1 (en) * 2000-01-28 2002-03-22 Sanofi Synthelabo 4-HETEROARYL-1,4-DIAZABICYCLO [3.2.2] NONANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2809732B1 (en) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVATIVES OF 4 (-2-PHENYLTHIAZOL-5-yl) -1,4-DIAZABICYCLO- [3.2.2] NONANE, THEIR PREPARATION AND THEIR THERAPY APPLICATION
FR2809731B1 (en) * 2000-05-31 2002-07-19 Sanofi Synthelabo 1,4-DIAZABICYCLO- [3.2.2] NONANE-PHEYLISOXAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US20020086871A1 (en) * 2000-12-29 2002-07-04 O'neill Brian Thomas Pharmaceutical composition for the treatment of CNS and other disorders
FR2832713B1 (en) * 2001-11-23 2004-02-13 Sanofi Synthelabo DERIVATIVES OF 4- (1,3,4-THIADIAZOL-2-YL) -1,4-DIAZABICYCLO [3.2.2] NONANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Also Published As

Publication number Publication date
MXPA05003344A (en) 2005-11-23
JP4711391B2 (en) 2011-06-29
IL166821A0 (en) 2006-01-15
KR20050062575A (en) 2005-06-23
BR0314183A (en) 2005-08-09
IS7829A (en) 2005-04-28
JP2006503062A (en) 2006-01-26
RU2323218C2 (en) 2008-04-27
IL166821A (en) 2009-06-15
NO20052124D0 (en) 2005-04-29
CN1326857C (en) 2007-07-18
PT1551835E (en) 2007-03-30
HK1081954A1 (en) 2006-05-26
SI1551835T1 (en) 2007-06-30
CN1684965A (en) 2005-10-19
RU2005105048A (en) 2005-11-20

Similar Documents

Publication Publication Date Title
NO20052124L (en) New 1,4-diazabicycloalkane derivatives, their preparation and use
DK1551835T3 (en) Newly known 1,4-diazabicycloalkane derivatives, their preparation and use
EP1416933B8 (en) Substituted piperidines as modulators of the melanocortin receptor
NO20071660L (en) Novel pyridinone derivatives and their use as positive allosteric modulators of MGLUR2 receptors
WO2004007481A3 (en) Substituted amine derivatives and methods of use in the treatment of angiogenesis relates disorders
WO2006067428A3 (en) 1, 2-diphenyl-imidazole derivatives and their use as cb1 receptor ligands
PL370381A1 (en) Substituted piperazines as modulators of the melanocortin receptor
CA2379445A1 (en) Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
WO2004014881A3 (en) '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5
EA200600811A1 (en) NEW TETRAHYDROSPIRO {PIPERIDIN-2,7'-PYRROLO [3,2-b] PYRIDINE} DERIVATIVES AND NEW INDOLA DERIVATIVES, APPLICATION FOR THE TREATMENT OF DISORDERS RELATED TO 5-HT-RECEPTOR
WO2004026248A3 (en) Octahydro-2-h-naphtho[1,2-f] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators
JP2013535460A (en) LSD1 arylcyclopropylamine based demethylase inhibitors and their medical use
WO2003048164A3 (en) Adenosine a2a receptor antagonists
WO2002068406A3 (en) Substituted amine derivatives and their use for the treatment of angiogenesis
WO2006053039A3 (en) Hydroxybenzoate salts of metanicotine compounds
TW200502221A (en) Novel lactams and uses thereof
MXPA04005209A (en) ADENOSINE A ??2a? RECEPTOR ANTAGONISTS.
MXPA05010883A (en) Cyclic amine derivatives and their use in the treatment of inflammation-related disorders mediated by bradykinin.
MY140835A (en) Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
CA2420177A1 (en) Quinazoline derivatives as alpha-1 adrenergic antagonists
TW200509933A (en) Therapeutic agents
CA2354606A1 (en) Azabicycloalkane derivatives and therapeutic uses thereof
WO2003072572A8 (en) Beta3-adrenergic receptor agonists
NZ533358A (en) 3,4-Dihydro-1H-isoquinolin-2-yl-derivatives for use as NK2 receptor antagonists
TW200504036A (en) Novel lactams and uses thereof