NO20045331L - Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof - Google Patents
Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereofInfo
- Publication number
- NO20045331L NO20045331L NO20045331A NO20045331A NO20045331L NO 20045331 L NO20045331 L NO 20045331L NO 20045331 A NO20045331 A NO 20045331A NO 20045331 A NO20045331 A NO 20045331A NO 20045331 L NO20045331 L NO 20045331L
- Authority
- NO
- Norway
- Prior art keywords
- group
- radical
- halogen atom
- atom
- therapeutic use
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 3
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 trifluoromethoxy radical Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
Den foreliggende oppfinnelse vedrører 1-substituerte piperazinylacylpiperidinderivater med generell formel (I) hvori: n er 1 eller 2; p er 1 eller 2; Ri representerer et halogenatom, et trifluormetylradikal, et C- Calkylradikal, et C-C- alkoksyradikal, et trifluormetoksyradikal; Rrepresenterer et hydrogenatom eller et halogenatom; Rrepresenterer et hydrogenatom, en -ORgruppe, en -CHORgruppe, en -NRRy gruppe, en -NRCORgruppe, en -NRCONRRgruppe, en -CHNRRgruppe, en -CHNRCONRRgruppe, en C-Calkoksykarbonylgruppe, en -CONRRgruppe; eller Rdanner en dobbeltbinding mellom karbonatomet hvortil det er bundet og det nærliggende karbonatom i piperidinringen; Rrepresenterer en aromatisk gruppe valgt blant (II), hvor de aromatiske gruppene er usubstituerte, monosubstituerte eller disubstituerte med en substituent som uavhengig er valgt blant et halogenatom, et C-C-alkylradikal, et C-Calkoksyradikal, et trifluormetylradikal.oppfinnelsen vedrører også en fremgangsmåte for å fremstille de nevnte forbindelser og deres terapeutiske anvendelse.The present invention relates to 1-substituted piperazinylacylpiperidine derivatives of general formula (I) wherein: n is 1 or 2; p is 1 or 2; R 1 represents a halogen atom, a trifluoromethyl radical, a C 1 -C 6 alkyl radical, a C 1 -C 4 alkoxy radical, a trifluoromethoxy radical; Represents a hydrogen atom or a halogen atom; R represents a hydrogen atom, a -OR group, a -CHOR group, a -NRRγ group, a -NRCOR group, a -NRCONRR group, a -CHNRR group, a -CHNRCONRR group, a C-Calkoxycarbonyl group, a -CONRR group; or R forms a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; Represents an aromatic group selected from (II), wherein the aromatic groups are unsubstituted, monosubstituted or disubstituted with a substituent independently selected from a halogen atom, a C 1-4 alkyl radical, a C 1 -C 6 alkoxy radical, a trifluoromethyl radical. The invention also relates to a process for to prepare the said compounds and their therapeutic use.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0207001 | 2002-06-07 | ||
| PCT/FR2003/001685 WO2003104225A1 (en) | 2002-06-07 | 2003-06-05 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20045331L true NO20045331L (en) | 2005-03-07 |
| NO329669B1 NO329669B1 (en) | 2010-11-29 |
Family
ID=29724874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045331A NO329669B1 (en) | 2002-06-07 | 2004-12-06 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7294628B2 (en) |
| EP (2) | EP1513835B1 (en) |
| JP (2) | JP4437075B2 (en) |
| KR (1) | KR100970812B1 (en) |
| CN (1) | CN100448875C (en) |
| AR (2) | AR040246A1 (en) |
| AT (2) | ATE325122T1 (en) |
| AU (2) | AU2003255645A1 (en) |
| BR (1) | BR0311828A (en) |
| CA (1) | CA2487840C (en) |
| CY (2) | CY1107330T1 (en) |
| DE (2) | DE60307632T2 (en) |
| DK (2) | DK1513835T3 (en) |
| EA (1) | EA007501B1 (en) |
| ES (2) | ES2264001T3 (en) |
| HK (1) | HK1076110A1 (en) |
| HR (1) | HRP20041157B1 (en) |
| IS (1) | IS2302B (en) |
| MA (1) | MA27233A1 (en) |
| ME (1) | MEP11508A (en) |
| MX (1) | MXPA04012341A (en) |
| NO (1) | NO329669B1 (en) |
| NZ (1) | NZ537044A (en) |
| PL (1) | PL208711B1 (en) |
| PT (2) | PT1513835E (en) |
| RS (2) | RS52588B (en) |
| TW (2) | TWI283671B (en) |
| UA (1) | UA77526C2 (en) |
| WO (2) | WO2003104226A1 (en) |
| ZA (1) | ZA200409823B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2862967B1 (en) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | (4-PHENYLPIPERAZIN-1-YL) ACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| FR2862968B1 (en) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | 4 - [(ARYLMETHYL) AMINOMETHYL] PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| EP1706392A2 (en) * | 2004-01-08 | 2006-10-04 | Syngenta Participations AG | Pesticidal heterocyclic dihaloallyl compounds |
| KR20070036148A (en) * | 2004-07-16 | 2007-04-02 | 얀센 파마슈티카 엔.브이. | Dimeric compounds of piperidine, piperazine or morpholine or their 7-membered analogs suitable for the treatment of neurodegenerative disorders |
| MX2007003318A (en) * | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes. |
| EP1871420A4 (en) * | 2005-04-15 | 2010-09-22 | Univ North Carolina | Methods of facilitating cell survival using neurotrophin mimetics |
| CA2680583A1 (en) * | 2007-03-15 | 2008-09-25 | Schering Corporation | Pyridazinone derivatives useful as glucan synthase inhibitors |
| EP2162135A4 (en) * | 2007-05-21 | 2012-02-22 | Reviva Pharmaceuticals Inc | Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents |
| DE102007026341A1 (en) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (en) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | pyridazinone derivatives |
| FR2932481B1 (en) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | 4- {2-4-PHENYL-3,6-DIHYDRO-2H-PYRIDIN-1-YL] -2-OXO-ALKYL} -1-PIPERAZIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
| FR2932482B1 (en) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | NOVEL (PHENYL-3,6-DIHYDRO-2H-PYRIDINYL) - (PIPERAZINYL PONTE) -1-ALKANONE DERIVATIVES AND THEIR USE AS P75 INHIBITORS |
| CN104761515B (en) | 2009-11-12 | 2018-03-09 | 特罗菲克斯制药股份有限公司 | The crystal formation of neurotrophin simulated compound and its salt |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| FR2953836B1 (en) * | 2009-12-14 | 2012-03-16 | Sanofi Aventis | NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75 |
| MX2012006776A (en) | 2009-12-14 | 2012-10-05 | Merck Patent Gmbh | Sphingosine kinase inhibitors. |
| FR2953839A1 (en) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | NOVEL (HETEROCYCLE-PIPERIDINE CONDENSEE) - (PIPERAZINYL) -1ALCANONE OR (HETEROCYCLE-PYRROLIDINE CONDENSED) - (PIPERAZINYL) -1ALCANONE DERIVATIVES AND THEIR USE AS INHIBITORS OF P75 |
| EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
| WO2019055966A2 (en) * | 2017-09-18 | 2019-03-21 | Goldfinch Bio, Inc. | Pyridazinones and methods of use thereof |
| AU2019344928A1 (en) | 2018-09-18 | 2021-04-29 | Goldfinch Bio, Inc. | Pyridazinones and methods of use thereof |
| EP3858439A1 (en) * | 2020-02-03 | 2021-08-04 | Esteve Pharmaceuticals, S.A. | Amide derivatives having multimodal activity against pain |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX173180B (en) * | 1987-10-26 | 1994-02-07 | Pfizer | PROCEDURE FOR PREPARING ANSIOLYTIC AGENTS |
| FR2747041B1 (en) * | 1996-04-05 | 1998-05-22 | Cird Galderma | USE OF BENZONAPHTHALENIC DERIVATIVES FOR THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF NEUROPATHIES |
| US6468990B1 (en) | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
| FR2803593B1 (en) | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | NOVEL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
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2003
- 2003-05-06 UA UA20041210010A patent/UA77526C2/en unknown
- 2003-06-05 AT AT03757109T patent/ATE325122T1/en active
- 2003-06-05 DE DE60307632T patent/DE60307632T2/en not_active Expired - Lifetime
- 2003-06-05 DK DK03757108T patent/DK1513835T3/en active
- 2003-06-05 ES ES03757109T patent/ES2264001T3/en not_active Expired - Lifetime
- 2003-06-05 JP JP2004511295A patent/JP4437075B2/en not_active Expired - Fee Related
- 2003-06-05 ME MEP-115/08A patent/MEP11508A/en unknown
- 2003-06-05 WO PCT/FR2003/001686 patent/WO2003104226A1/en active IP Right Grant
- 2003-06-05 US US10/516,808 patent/US7294628B2/en active Active
- 2003-06-05 EA EA200401470A patent/EA007501B1/en not_active IP Right Cessation
- 2003-06-05 RS RS20050014A patent/RS52588B/en unknown
- 2003-06-05 KR KR1020047019860A patent/KR100970812B1/en not_active IP Right Cessation
- 2003-06-05 EP EP03757108A patent/EP1513835B1/en not_active Expired - Lifetime
- 2003-06-05 RS YUP-2005/0014A patent/RS20050014A/en unknown
- 2003-06-05 BR BR0311828-2A patent/BR0311828A/en not_active IP Right Cessation
- 2003-06-05 EP EP03757109A patent/EP1513836B1/en not_active Expired - Lifetime
- 2003-06-05 AU AU2003255645A patent/AU2003255645A1/en not_active Abandoned
- 2003-06-05 WO PCT/FR2003/001685 patent/WO2003104225A1/en active IP Right Grant
- 2003-06-05 DE DE60305037T patent/DE60305037T2/en not_active Expired - Lifetime
- 2003-06-05 PT PT03757108T patent/PT1513835E/en unknown
- 2003-06-05 US US10/516,704 patent/US7468368B2/en active Active
- 2003-06-05 DK DK03757109T patent/DK1513836T3/en active
- 2003-06-05 MX MXPA04012341A patent/MXPA04012341A/en active IP Right Grant
- 2003-06-05 CA CA2487840A patent/CA2487840C/en not_active Expired - Fee Related
- 2003-06-05 JP JP2004511296A patent/JP4441401B2/en not_active Expired - Fee Related
- 2003-06-05 NZ NZ537044A patent/NZ537044A/en not_active IP Right Cessation
- 2003-06-05 CN CNB038188082A patent/CN100448875C/en not_active Expired - Fee Related
- 2003-06-05 PL PL374729A patent/PL208711B1/en not_active IP Right Cessation
- 2003-06-05 PT PT03757109T patent/PT1513836E/en unknown
- 2003-06-05 ES ES03757108T patent/ES2271637T3/en not_active Expired - Lifetime
- 2003-06-05 AT AT03757108T patent/ATE336491T1/en active
- 2003-06-05 AU AU2003255644A patent/AU2003255644B2/en not_active Ceased
- 2003-06-06 TW TW092115416A patent/TWI283671B/en not_active IP Right Cessation
- 2003-06-06 AR ARP030102017A patent/AR040246A1/en active IP Right Grant
- 2003-06-06 AR ARP030102018A patent/AR040247A1/en active IP Right Grant
- 2003-06-06 TW TW092115443A patent/TWI319400B/en not_active IP Right Cessation
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2004
- 2004-12-02 IS IS7579A patent/IS2302B/en unknown
- 2004-12-03 ZA ZA200409823A patent/ZA200409823B/en unknown
- 2004-12-03 MA MA27980A patent/MA27233A1/en unknown
- 2004-12-06 HR HR20041157 patent/HRP20041157B1/en not_active IP Right Cessation
- 2004-12-06 NO NO20045331A patent/NO329669B1/en not_active IP Right Cessation
-
2005
- 2005-11-19 HK HK05110460.5A patent/HK1076110A1/en not_active IP Right Cessation
-
2006
- 2006-08-03 CY CY20061101094T patent/CY1107330T1/en unknown
- 2006-11-15 CY CY20061101660T patent/CY1105784T1/en unknown
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