NO20045331L - Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof - Google Patents
Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereofInfo
- Publication number
- NO20045331L NO20045331L NO20045331A NO20045331A NO20045331L NO 20045331 L NO20045331 L NO 20045331L NO 20045331 A NO20045331 A NO 20045331A NO 20045331 A NO20045331 A NO 20045331A NO 20045331 L NO20045331 L NO 20045331L
- Authority
- NO
- Norway
- Prior art keywords
- group
- radical
- halogen atom
- atom
- therapeutic use
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 3
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 trifluoromethoxy radical Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Den foreliggende oppfinnelse vedrører 1-substituerte piperazinylacylpiperidinderivater med generell formel (I) hvori: n er 1 eller 2; p er 1 eller 2; Ri representerer et halogenatom, et trifluormetylradikal, et C- Calkylradikal, et C-C- alkoksyradikal, et trifluormetoksyradikal; Rrepresenterer et hydrogenatom eller et halogenatom; Rrepresenterer et hydrogenatom, en -ORgruppe, en -CHORgruppe, en -NRRy gruppe, en -NRCORgruppe, en -NRCONRRgruppe, en -CHNRRgruppe, en -CHNRCONRRgruppe, en C-Calkoksykarbonylgruppe, en -CONRRgruppe; eller Rdanner en dobbeltbinding mellom karbonatomet hvortil det er bundet og det nærliggende karbonatom i piperidinringen; Rrepresenterer en aromatisk gruppe valgt blant (II), hvor de aromatiske gruppene er usubstituerte, monosubstituerte eller disubstituerte med en substituent som uavhengig er valgt blant et halogenatom, et C-C-alkylradikal, et C-Calkoksyradikal, et trifluormetylradikal.oppfinnelsen vedrører også en fremgangsmåte for å fremstille de nevnte forbindelser og deres terapeutiske anvendelse.The present invention relates to 1-substituted piperazinylacylpiperidine derivatives of general formula (I) wherein: n is 1 or 2; p is 1 or 2; R 1 represents a halogen atom, a trifluoromethyl radical, a C 1 -C 6 alkyl radical, a C 1 -C 4 alkoxy radical, a trifluoromethoxy radical; Represents a hydrogen atom or a halogen atom; R represents a hydrogen atom, a -OR group, a -CHOR group, a -NRRγ group, a -NRCOR group, a -NRCONRR group, a -CHNRR group, a -CHNRCONRR group, a C-Calkoxycarbonyl group, a -CONRR group; or R forms a double bond between the carbon atom to which it is attached and the adjacent carbon atom of the piperidine ring; Represents an aromatic group selected from (II), wherein the aromatic groups are unsubstituted, monosubstituted or disubstituted with a substituent independently selected from a halogen atom, a C 1-4 alkyl radical, a C 1 -C 6 alkoxy radical, a trifluoromethyl radical. The invention also relates to a process for to prepare the said compounds and their therapeutic use.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0207001 | 2002-06-07 | ||
PCT/FR2003/001685 WO2003104225A1 (en) | 2002-06-07 | 2003-06-05 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20045331L true NO20045331L (en) | 2005-03-07 |
NO329669B1 NO329669B1 (en) | 2010-11-29 |
Family
ID=29724874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20045331A NO329669B1 (en) | 2002-06-07 | 2004-12-06 | Piperazinylacylpiperidine derivatives, their preparation and therapeutic use |
Country Status (30)
Country | Link |
---|---|
US (2) | US7468368B2 (en) |
EP (2) | EP1513836B1 (en) |
JP (2) | JP4437075B2 (en) |
KR (1) | KR100970812B1 (en) |
CN (1) | CN100448875C (en) |
AR (2) | AR040246A1 (en) |
AT (2) | ATE336491T1 (en) |
AU (2) | AU2003255645A1 (en) |
BR (1) | BR0311828A (en) |
CA (1) | CA2487840C (en) |
CY (2) | CY1107330T1 (en) |
DE (2) | DE60305037T2 (en) |
DK (2) | DK1513836T3 (en) |
EA (1) | EA007501B1 (en) |
ES (2) | ES2264001T3 (en) |
HK (1) | HK1076110A1 (en) |
HR (1) | HRP20041157B1 (en) |
IS (1) | IS2302B (en) |
MA (1) | MA27233A1 (en) |
ME (1) | MEP11508A (en) |
MX (1) | MXPA04012341A (en) |
NO (1) | NO329669B1 (en) |
NZ (1) | NZ537044A (en) |
PL (1) | PL208711B1 (en) |
PT (2) | PT1513835E (en) |
RS (2) | RS52588B (en) |
TW (2) | TWI283671B (en) |
UA (1) | UA77526C2 (en) |
WO (2) | WO2003104225A1 (en) |
ZA (1) | ZA200409823B (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2862967B1 (en) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | (4-PHENYLPIPERAZIN-1-YL) ACYLPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
FR2862968B1 (en) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | 4 - [(ARYLMETHYL) AMINOMETHYL] PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
WO2005068445A2 (en) * | 2004-01-08 | 2005-07-28 | Syngenta Participations Ag | Pesticidal heterocyclic dihaloallyl compounds |
AU2005263718A1 (en) * | 2004-07-16 | 2006-01-26 | Janssen Pharmaceutica N.V. | Dimeric compounds of piperidine, piperazine or morpholine or their 7-membered analogs suitabale for the treatment of neurodegenerative disorders |
BRPI0515483A (en) * | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | heterocyclic derivatives for the treatment of stearoyl coa desaturase mediated diseases |
EP2594318B1 (en) * | 2005-04-15 | 2020-06-10 | University Of North Carolina At Chapel Hill | Methods of facilitating cell survival using neurotrophin mimetics |
PE20081882A1 (en) * | 2007-03-15 | 2008-12-27 | Schering Corp | USEFUL PYRIDAZINONE DERIVATIVES AS GLUCAN SYNTHASE INHIBITORS |
AU2008254585B2 (en) * | 2007-05-21 | 2013-09-26 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents |
DE102007026341A1 (en) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (en) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | pyridazinone derivatives |
FR2932482B1 (en) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | NOVEL (PHENYL-3,6-DIHYDRO-2H-PYRIDINYL) - (PIPERAZINYL PONTE) -1-ALKANONE DERIVATIVES AND THEIR USE AS P75 INHIBITORS |
FR2932481B1 (en) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | 4- {2-4-PHENYL-3,6-DIHYDRO-2H-PYRIDIN-1-YL] -2-OXO-ALKYL} -1-PIPERAZIN-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
JP5863663B2 (en) | 2009-11-12 | 2016-02-16 | ファーマトロフィックス, インコーポレイテッド | Crystal forms of neurotrophin mimetic compounds and their salts |
US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
WO2011072791A1 (en) | 2009-12-14 | 2011-06-23 | Merck Patent Gmbh | Sphingosine kinase inhibitors |
FR2953839A1 (en) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | NOVEL (HETEROCYCLE-PIPERIDINE CONDENSEE) - (PIPERAZINYL) -1ALCANONE OR (HETEROCYCLE-PYRROLIDINE CONDENSED) - (PIPERAZINYL) -1ALCANONE DERIVATIVES AND THEIR USE AS INHIBITORS OF P75 |
FR2953836B1 (en) * | 2009-12-14 | 2012-03-16 | Sanofi Aventis | NOVEL DERIVATIVES (HETEROCYCLE-TETRAHYDRO-PYRIDINE) - (PIPERAZINYL) -1-ALKANONE AND (HETEROCYCLE-DIHYDRO-PYRROLIDINE) - (PIPERAZINYL) -1-ALKANONE AND THEIR USE AS INHIBITORS OF P75 |
EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
AU2018334290A1 (en) * | 2017-09-18 | 2020-04-02 | Goldfinch Bio, Inc. | Pyridazinones and methods of use thereof |
UY38377A (en) | 2018-09-18 | 2020-04-30 | Goldfinch Bio Inc | PYRIDAZINONES AND THEIR METHODS OF USE |
EP3858439A1 (en) * | 2020-02-03 | 2021-08-04 | Esteve Pharmaceuticals, S.A. | Amide derivatives having multimodal activity against pain |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX173180B (en) * | 1987-10-26 | 1994-02-07 | Pfizer | PROCEDURE FOR PREPARING ANSIOLYTIC AGENTS |
FR2747041B1 (en) * | 1996-04-05 | 1998-05-22 | Cird Galderma | USE OF BENZONAPHTHALENIC DERIVATIVES FOR THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF NEUROPATHIES |
US6468990B1 (en) * | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
FR2803593B1 (en) * | 2000-01-06 | 2002-02-15 | Sanofi Synthelabo | NOVEL TETRAHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
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2003
- 2003-05-06 UA UA20041210010A patent/UA77526C2/en unknown
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- 2003-06-05 WO PCT/FR2003/001685 patent/WO2003104225A1/en active IP Right Grant
- 2003-06-05 US US10/516,704 patent/US7468368B2/en active Active
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- 2003-06-05 AU AU2003255644A patent/AU2003255644B2/en not_active Ceased
- 2003-06-05 CN CNB038188082A patent/CN100448875C/en not_active Expired - Fee Related
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- 2003-06-05 CA CA2487840A patent/CA2487840C/en not_active Expired - Fee Related
- 2003-06-05 JP JP2004511295A patent/JP4437075B2/en not_active Expired - Fee Related
- 2003-06-05 JP JP2004511296A patent/JP4441401B2/en not_active Expired - Fee Related
- 2003-06-05 PL PL374729A patent/PL208711B1/en not_active IP Right Cessation
- 2003-06-05 DE DE60305037T patent/DE60305037T2/en not_active Expired - Lifetime
- 2003-06-05 MX MXPA04012341A patent/MXPA04012341A/en active IP Right Grant
- 2003-06-05 AT AT03757108T patent/ATE336491T1/en active
- 2003-06-05 EP EP03757109A patent/EP1513836B1/en not_active Expired - Lifetime
- 2003-06-05 ME MEP-115/08A patent/MEP11508A/en unknown
- 2003-06-05 DE DE60307632T patent/DE60307632T2/en not_active Expired - Lifetime
- 2003-06-05 ES ES03757108T patent/ES2271637T3/en not_active Expired - Lifetime
- 2003-06-05 EP EP03757108A patent/EP1513835B1/en not_active Expired - Lifetime
- 2003-06-05 US US10/516,808 patent/US7294628B2/en active Active
- 2003-06-05 NZ NZ537044A patent/NZ537044A/en not_active IP Right Cessation
- 2003-06-05 AT AT03757109T patent/ATE325122T1/en active
- 2003-06-05 RS YUP-2005/0014A patent/RS20050014A/en unknown
- 2003-06-05 WO PCT/FR2003/001686 patent/WO2003104226A1/en active IP Right Grant
- 2003-06-05 EA EA200401470A patent/EA007501B1/en not_active IP Right Cessation
- 2003-06-05 PT PT03757109T patent/PT1513836E/en unknown
- 2003-06-05 KR KR1020047019860A patent/KR100970812B1/en not_active IP Right Cessation
- 2003-06-05 DK DK03757108T patent/DK1513835T3/en active
- 2003-06-06 TW TW092115416A patent/TWI283671B/en not_active IP Right Cessation
- 2003-06-06 TW TW092115443A patent/TWI319400B/en not_active IP Right Cessation
- 2003-06-06 AR ARP030102017A patent/AR040246A1/en active IP Right Grant
- 2003-06-06 AR ARP030102018A patent/AR040247A1/en active IP Right Grant
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2004
- 2004-12-02 IS IS7579A patent/IS2302B/en unknown
- 2004-12-03 ZA ZA200409823A patent/ZA200409823B/en unknown
- 2004-12-03 MA MA27980A patent/MA27233A1/en unknown
- 2004-12-06 NO NO20045331A patent/NO329669B1/en not_active IP Right Cessation
- 2004-12-06 HR HR20041157 patent/HRP20041157B1/en not_active IP Right Cessation
-
2005
- 2005-11-19 HK HK05110460.5A patent/HK1076110A1/en not_active IP Right Cessation
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2006
- 2006-08-03 CY CY20061101094T patent/CY1107330T1/en unknown
- 2006-11-15 CY CY20061101660T patent/CY1105784T1/en unknown
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