NO20004251L - Humanized anti-CEA high affinity monoclonal antibodies - Google Patents
Humanized anti-CEA high affinity monoclonal antibodiesInfo
- Publication number
- NO20004251L NO20004251L NO20004251A NO20004251A NO20004251L NO 20004251 L NO20004251 L NO 20004251L NO 20004251 A NO20004251 A NO 20004251A NO 20004251 A NO20004251 A NO 20004251A NO 20004251 L NO20004251 L NO 20004251L
- Authority
- NO
- Norway
- Prior art keywords
- monoclonal antibodies
- high affinity
- humanized anti
- affinity monoclonal
- tag
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6853—Carcino-embryonic antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57473—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen, i.e. CEA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Nye humaniserte monoklonale antistoffer, humaniserte antistoff-fragmenter og derivater derav som spesifikt binder TAG-72 er beskrevet, samt fremgangsmåter for fremstilling derav. Disse humaniserte antistoffene er nyttige for behandling av cancer som uttrykker TAG-72 samt for diagnostiske formål, f.eks iv vivo billed-dannelse av tumorer eller cancerceller som uttrykker TAG-72.New humanized monoclonal antibodies, humanized antibody fragments and derivatives thereof that specifically bind TAG-72 are described, as well as methods for their production. These humanized antibodies are useful for the treatment of cancers that express TAG-72 as well as for diagnostic purposes, eg iv vivo imaging of tumors or cancer cells that express TAG-72.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1998/003680 WO1999043817A1 (en) | 1998-02-25 | 1998-02-25 | High affinity humanized anti-cea monoclonal antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20004251D0 NO20004251D0 (en) | 2000-08-24 |
NO20004251L true NO20004251L (en) | 2000-10-24 |
Family
ID=22266464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20004251A NO20004251L (en) | 1998-02-25 | 2000-08-24 | Humanized anti-CEA high affinity monoclonal antibodies |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1056859A1 (en) |
JP (1) | JP2002504372A (en) |
AU (1) | AU752494B2 (en) |
CA (1) | CA2321947A1 (en) |
IL (1) | IL138022A0 (en) |
NO (1) | NO20004251L (en) |
WO (1) | WO1999043817A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003025565A2 (en) * | 2001-09-21 | 2003-03-27 | Caprion Pharmaceuticals Inc. | Preparation of highly-purified plasma membranes |
CA2609142C (en) * | 2005-05-27 | 2016-02-09 | Fondazione Centro San Raffaele Del Monte Tabor | Therapeutic gene vectors comprising mirna target sequences |
PL2681244T3 (en) * | 2011-03-02 | 2018-04-30 | Roche Glycart Ag | Cea antibodies |
EA201892619A1 (en) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | IMMUNOCONJUGATES CONTAINING INTERLEUKIN-2 MUTANT POLYPETIPS |
CN111499750B (en) * | 2016-12-04 | 2022-02-08 | 深圳市国创纳米抗体技术有限公司 | High-neutralization-activity nano antibody for resisting carcinoembryonic antigen and application thereof |
TW202115125A (en) | 2019-06-26 | 2021-04-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | Anti-cea antibody and the use thereof |
IL300497A (en) | 2020-08-20 | 2023-04-01 | A2 Biotherapeutics Inc | Compositions and methods for treating ceacam positive cancers |
MX2023002041A (en) | 2020-08-20 | 2023-04-27 | A2 Biotherapeutics Inc | Compositions and methods for treating mesothelin positive cancers. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9014932D0 (en) * | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
US5472693A (en) * | 1993-02-16 | 1995-12-05 | The Dow Chemical Company | Family of anti-carcinoembryonic antigen chimeric antibodies |
US5874540A (en) * | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
HUP9901562A3 (en) * | 1996-05-04 | 2000-06-28 | Astrazeneca Ab | Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system |
-
1998
- 1998-02-25 CA CA002321947A patent/CA2321947A1/en not_active Abandoned
- 1998-02-25 WO PCT/US1998/003680 patent/WO1999043817A1/en not_active Application Discontinuation
- 1998-02-25 IL IL13802298A patent/IL138022A0/en unknown
- 1998-02-25 JP JP2000533557A patent/JP2002504372A/en active Pending
- 1998-02-25 AU AU63388/98A patent/AU752494B2/en not_active Ceased
- 1998-02-25 EP EP98907630A patent/EP1056859A1/en not_active Withdrawn
-
2000
- 2000-08-24 NO NO20004251A patent/NO20004251L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1056859A1 (en) | 2000-12-06 |
WO1999043817A1 (en) | 1999-09-02 |
IL138022A0 (en) | 2001-10-31 |
AU752494B2 (en) | 2002-09-19 |
JP2002504372A (en) | 2002-02-12 |
AU6338898A (en) | 1999-09-15 |
CA2321947A1 (en) | 1999-09-02 |
NO20004251D0 (en) | 2000-08-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |