NO178433C - Analogous Process for Preparation of Therapeutically Active Peptide with Bradykin Antagonistic Effect - Google Patents

Analogous Process for Preparation of Therapeutically Active Peptide with Bradykin Antagonistic Effect

Info

Publication number
NO178433C
NO178433C NO903545A NO903545A NO178433C NO 178433 C NO178433 C NO 178433C NO 903545 A NO903545 A NO 903545A NO 903545 A NO903545 A NO 903545A NO 178433 C NO178433 C NO 178433C
Authority
NO
Norway
Prior art keywords
amino acid
bradykin
preparation
direct bond
bradykinin
Prior art date
Application number
NO903545A
Other languages
Norwegian (no)
Other versions
NO903545L (en
NO903545D0 (en
NO178433B (en
Inventor
Stephan Henke
Gerhard Breipohl
Jochen Knolle
Bernward Scholkens
Hermann Gerhards
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO903545D0 publication Critical patent/NO903545D0/en
Publication of NO903545L publication Critical patent/NO903545L/en
Publication of NO178433B publication Critical patent/NO178433B/en
Publication of NO178433C publication Critical patent/NO178433C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Peptides of the formula I A-B-C-E-F-K-(D)-Phe-G-M-F'-I (1> in which A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulphonyl, cycloalkyl, aryl, aryloyl, arylsulphonyl, heteroaryl or an amino acid, each of which can optionally be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the residue of an aromatic amino acid, F is, independently of one another, an amino acid which is optionally substituted in the side chain or is a direct bond, G is an amino acid, F' is defined as F or can be -NH-(CH2)2-8 or optionally a direct bond, I is -OH, -NH2 or -NHC2H5, and K is a radical -NH-(CH2)1-4-CO- or is a direct bond, act as bradykinin antagonists. Their therapeutic uses comprise all pathological states promoted, induced or assisted by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.
NO903545A 1989-08-14 1990-08-13 Analogous Process for Preparation of Therapeutically Active Peptide with Bradykin Antagonistic Effect NO178433C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3926822A DE3926822A1 (en) 1989-08-14 1989-08-14 PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT

Publications (4)

Publication Number Publication Date
NO903545D0 NO903545D0 (en) 1990-08-13
NO903545L NO903545L (en) 1991-02-15
NO178433B NO178433B (en) 1995-12-18
NO178433C true NO178433C (en) 1996-03-27

Family

ID=6387091

Family Applications (1)

Application Number Title Priority Date Filing Date
NO903545A NO178433C (en) 1989-08-14 1990-08-13 Analogous Process for Preparation of Therapeutically Active Peptide with Bradykin Antagonistic Effect

Country Status (24)

Country Link
EP (1) EP0413277B1 (en)
JP (1) JP2997519B2 (en)
KR (1) KR0173976B1 (en)
CN (1) CN1034577C (en)
AT (1) ATE114320T1 (en)
AU (1) AU638735B2 (en)
CA (1) CA2023194C (en)
CY (1) CY2029A (en)
CZ (1) CZ284783B6 (en)
DD (1) DD297169A5 (en)
DE (2) DE3926822A1 (en)
DK (1) DK0413277T3 (en)
ES (1) ES2065445T3 (en)
FI (1) FI102759B (en)
HU (1) HU208324B (en)
IE (1) IE65356B1 (en)
IL (1) IL95357A (en)
LT (1) LT3868B (en)
NO (1) NO178433C (en)
NZ (1) NZ234861A (en)
PT (1) PT94982B (en)
RU (1) RU2081880C1 (en)
SK (1) SK280787B6 (en)
ZA (1) ZA906381B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4013270A1 (en) * 1990-04-26 1991-10-31 Hoechst Ag PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT
WO1992017201A1 (en) * 1991-04-01 1992-10-15 Cortech, Inc. Bradykinin antagonists
CA2106768C (en) 1991-04-19 2000-09-19 Donald J. Kyle Bradykinin type peptides
US6770741B1 (en) 1991-04-19 2004-08-03 Scios Inc. Bradykinin antagonist peptides
JPH07504155A (en) * 1991-04-19 1995-05-11 シオス・ノヴァ・インコーポレイテット bradykinin antagonist peptide
US5380875A (en) * 1991-06-06 1995-01-10 Hitachi Chemical Company, Ltd. Hydroxyproline derivatives and preparative process therefor
WO1993011789A1 (en) 1991-12-12 1993-06-24 Scios Nova Inc. Modified position (7) bradykinin antagonist peptides
TW199863B (en) * 1991-12-21 1993-02-11 Hoechst Ag
TW258739B (en) * 1992-04-04 1995-10-01 Hoechst Ag
US5521158A (en) * 1992-10-08 1996-05-28 Scios Nova Inc. Pseudopeptide bradykinin receptor antagonists
US5686565A (en) * 1992-10-08 1997-11-11 Scios Inc. Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
US5610142A (en) * 1992-10-08 1997-03-11 Scios Inc. Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids
US5541286A (en) * 1992-10-08 1996-07-30 Scios Nova Inc. Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
WO1994019372A1 (en) * 1993-02-17 1994-09-01 Scios Nova Inc. Cyclic bradykinin antagonist peptides
US5817756A (en) * 1993-09-09 1998-10-06 Scios Inc. Pseudo- and non-peptide bradykinin receptor antagonists
FR2739553B1 (en) 1995-10-06 1998-01-02 Oreal USE OF BRADYKININE ANTAGONISTS TO STIMULATE OR INDUCE HAIR GROWTH AND / OR STOP THE HAIR LOSS
DE19612067A1 (en) * 1996-03-27 1997-10-02 Hoechst Ag Use of bradykinin antagonists for the manufacture of medicaments for the treatment of chronic fibrogenetic liver diseases and acute liver diseases
FR2756566B1 (en) * 1996-12-04 1999-01-08 Fournier Ind & Sante BRADYKININ B2 RECEPTOR AGONIST PEPTIDES, METHOD OF PREPARATION AND USE IN THERAPEUTICS
JP5064213B2 (en) * 2004-06-17 2012-10-31 インフィニティ・ディスカバリー・インコーポレイテッド Compounds and methods for inhibiting the interaction of a BCL protein with a binding partner
KR101707887B1 (en) * 2016-11-22 2017-02-17 홍인석 manufacturing apparatus of packaging paper that attach fragrance sheet and the manufacturing method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4693993A (en) 1985-06-13 1987-09-15 Stewart John M Bradykinin antagonist peptides
DE3618218A1 (en) 1986-05-30 1987-12-03 Hoechst Ag AMINO ACID OOBT ESTER, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3635670A1 (en) 1986-10-21 1988-04-28 Hoechst Ag SYNTHESIS OF PEPTIDE-AMINOALKYLAMIDES AND PEPTIDYHYDRAZIDES BY MEANS OF THE SOLID PHASE METHOD
EP0332688A4 (en) * 1987-09-02 1990-09-26 John M. Stewart Bradykinin antagonist peptides
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides

Also Published As

Publication number Publication date
CS397990A3 (en) 1992-03-18
RU2081880C1 (en) 1997-06-20
LT3868B (en) 1996-04-25
DE59007747D1 (en) 1995-01-05
KR0173976B1 (en) 1999-02-01
CN1049505A (en) 1991-02-27
FI102759B1 (en) 1999-02-15
JP2997519B2 (en) 2000-01-11
NO903545L (en) 1991-02-15
LTIP1466A (en) 1995-06-26
AU638735B2 (en) 1993-07-08
FI903971A0 (en) 1990-08-10
IE902923A1 (en) 1991-02-27
NO903545D0 (en) 1990-08-13
HUT54712A (en) 1991-03-28
NZ234861A (en) 1992-09-25
HU904989D0 (en) 1991-01-28
PT94982B (en) 1997-04-30
IL95357A0 (en) 1991-06-30
ZA906381B (en) 1991-05-29
IL95357A (en) 1995-08-31
ATE114320T1 (en) 1994-12-15
FI102759B (en) 1999-02-15
DD297169A5 (en) 1992-01-02
IE65356B1 (en) 1995-10-18
HU208324B (en) 1993-09-28
SK280787B6 (en) 2000-07-11
KR910004662A (en) 1991-03-29
CY2029A (en) 1998-02-20
CA2023194A1 (en) 1991-02-15
EP0413277A1 (en) 1991-02-20
AU6092490A (en) 1991-02-21
ES2065445T3 (en) 1995-02-16
CA2023194C (en) 2001-09-11
CZ284783B6 (en) 1999-03-17
DE3926822A1 (en) 1991-02-21
EP0413277B1 (en) 1994-11-23
DK0413277T3 (en) 1995-04-18
NO178433B (en) 1995-12-18
CN1034577C (en) 1997-04-16
JPH0386898A (en) 1991-04-11
PT94982A (en) 1991-04-18

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NO178433C (en) Analogous Process for Preparation of Therapeutically Active Peptide with Bradykin Antagonistic Effect
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