NO175978C - Analogous process for the preparation of therapeutically active bis-aza-bicyclic compounds - Google Patents

Analogous process for the preparation of therapeutically active bis-aza-bicyclic compounds

Info

Publication number
NO175978C
NO175978C NO912863A NO912863A NO175978C NO 175978 C NO175978 C NO 175978C NO 912863 A NO912863 A NO 912863A NO 912863 A NO912863 A NO 912863A NO 175978 C NO175978 C NO 175978C
Authority
NO
Norway
Prior art keywords
aza
preparation
therapeutically active
bicyclic compounds
analogous process
Prior art date
Application number
NO912863A
Other languages
Norwegian (no)
Other versions
NO912863L (en
NO175978B (en
NO912863D0 (en
Inventor
Gene Michael Bright
Kishor A Desai
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO912863L publication Critical patent/NO912863L/en
Publication of NO912863D0 publication Critical patent/NO912863D0/en
Publication of NO175978B publication Critical patent/NO175978B/en
Publication of NO175978C publication Critical patent/NO175978C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
NO912863A 1989-01-23 1991-07-22 Analogous process for the preparation of therapeutically active bis-aza-bicyclic compounds NO175978C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1989/000275 WO1990008148A1 (en) 1989-01-23 1989-01-23 Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 WO1990008144A1 (en) 1989-01-23 1989-09-01 Bis-aza-bicyclic anxiolytic agents

Publications (4)

Publication Number Publication Date
NO912863L NO912863L (en) 1991-07-22
NO912863D0 NO912863D0 (en) 1991-07-22
NO175978B NO175978B (en) 1994-10-03
NO175978C true NO175978C (en) 1995-01-11

Family

ID=22214801

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912863A NO175978C (en) 1989-01-23 1991-07-22 Analogous process for the preparation of therapeutically active bis-aza-bicyclic compounds

Country Status (38)

Country Link
US (1) US5122525A (en)
EP (1) EP0380217B1 (en)
JP (1) JPH0643427B2 (en)
KR (1) KR910009289B1 (en)
CN (1) CN1022186C (en)
AP (1) AP128A (en)
AR (1) AR246969A1 (en)
AT (1) ATE82574T1 (en)
AU (1) AU614214B2 (en)
BA (1) BA98302A (en)
BG (1) BG51046A3 (en)
CA (1) CA2008108C (en)
CZ (1) CZ277698B6 (en)
DD (1) DD291560A5 (en)
DE (1) DE69000467T2 (en)
DK (1) DK0380217T3 (en)
EG (1) EG19306A (en)
ES (1) ES2053094T3 (en)
FI (1) FI95381C (en)
GR (1) GR3006925T3 (en)
HU (1) HU215154B (en)
IE (1) IE62670B1 (en)
IL (1) IL93073A (en)
IS (1) IS1667B (en)
MA (1) MA21735A1 (en)
MX (1) MX19222A (en)
MY (1) MY104861A (en)
NO (1) NO175978C (en)
NZ (1) NZ232168A (en)
OA (1) OA10041A (en)
PL (1) PL163836B1 (en)
PT (1) PT92919B (en)
RO (1) RO110142B1 (en)
RU (1) RU2015977C1 (en)
SK (1) SK279339B6 (en)
WO (2) WO1990008148A1 (en)
YU (1) YU47554B (en)
ZA (1) ZA90430B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
WO1992000075A1 (en) * 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
ES2072141T3 (en) * 1991-01-31 1995-07-01 Pfizer RESOLUTION OF TRANS-2- (2-PIRIMIDINIL) -7- (HYDROXIMETIL) OCTAHIDRO-2H-PIRIDO (1,2A) PIRAZINA.
US5326874A (en) * 1991-02-27 1994-07-05 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5311195A (en) * 1991-08-30 1994-05-10 Etak, Inc. Combined relative and absolute positioning method and apparatus
BR9206541A (en) * 1991-09-25 1995-04-25 Pfizer Per-hydro-1h-pyrido (1,2-a) 2-substituted neuroleptic pyrazines
ATE185565T1 (en) * 1992-06-16 1999-10-15 Pfizer METHOD AND INTERMEDIATE PRODUCTS FOR PRODUCING BIS-AZA-BICYCLIC ANXIOLYTICS
AU5291793A (en) * 1992-09-24 1994-04-12 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) * 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) * 1993-08-20 1997-06-10 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) * 1993-11-01 1999-06-20 Israel State Controlled cryogenic contact system
US5731307A (en) * 1994-09-30 1998-03-24 Pfizer, Inc. Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
US5852031A (en) * 1994-09-30 1998-12-22 Pfizer Inc. 2,7-substituted octahydro-1H-pyrido 1,2-a!pyrazine derivatives
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
HUP9900611A3 (en) * 1995-12-21 2000-09-28 Pfizer 2,7-substituted octahydro-pyrrolo[1,2-a]pyrazine derivatives, pharmaceutical compositions containing them and intermediates for the preparation of the compounds
KR20000022490A (en) * 1996-07-01 2000-04-25 스피겔 알렌 제이 Preparation of (7s,trans) - 2- (2-pyrimidinyl) - 7 - (hydroxymethyl) octahydro -2h - pyrido[ 1,2-a]pyrazine
PA8469101A1 (en) * 1998-04-09 2000-09-29 Pfizer Prod Inc AZABICICLIC LEAGUES OF RECEIVERS 5HT1
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (en) * 1998-09-21 2000-11-11 Pfizer Prod Inc PHARMACEUTICAL AGENTS FOR THE TREATMENT OF PARKINSON'S DISEASE, ADHD AND MICROADENOMAS.
US20020016334A1 (en) * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
AP2005003390A0 (en) * 2003-03-12 2005-09-30 Pfizer Prod Inc Pyridyloxymethyl and benzisoxazole azabicyclic derivatives.
ATE418555T1 (en) 2003-04-09 2009-01-15 Biogen Idec Inc A2A ADENOSIN RECEPTOR ANTAGONISTS
EP1689721B1 (en) * 2003-11-26 2010-07-14 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
BRPI0511529A (en) * 2004-05-27 2008-01-02 Warner Lambert Co therapeutic combination for attention deficit hyperactivity disorder
US7658206B2 (en) 2006-12-05 2010-02-09 Kohler Co. Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4339579A (en) * 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) * 1982-05-25 1983-11-08 American Home Products Corporation 4-Substituted-piperidino carboxamides
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (en) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-PYRIMIDINYL-1-PIPERAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
DE3409440A1 (en) * 1984-03-15 1985-09-26 Bayer Ag, 5090 Leverkusen IMIDAZO (1,5-A) PYRIDYL METHANE AND IMIDAZO (1,5-B) PYRIDAZINYLMETHANE DERIVATIVES, THEIR PRODUCTION AND THE RECORDING MATERIALS CONTAINING THEM
IT1204803B (en) * 1986-02-17 1989-03-10 Acraf PHARMACOLOGICALLY ACTIVE COMPOUND AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT, PROCEDURE TO PREPARE IT AND INTERMEDIATE USEFUL IN THAT PROCEDURE
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2668259B2 (en) * 1988-02-18 1997-10-27 塩野義製薬株式会社 Heterocyclic compounds and anti-ulcer agents
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents

Also Published As

Publication number Publication date
NZ232168A (en) 1991-08-27
WO1990008144A1 (en) 1990-07-26
CZ277698B6 (en) 1993-03-17
US5122525A (en) 1992-06-16
DD291560A5 (en) 1991-07-04
PL163836B1 (en) 1994-05-31
CN1044464A (en) 1990-08-08
EP0380217B1 (en) 1992-11-19
FI913510A0 (en) 1991-07-22
RU2015977C1 (en) 1994-07-15
AU4867990A (en) 1990-07-26
DE69000467T2 (en) 1993-04-01
RO110142B1 (en) 1995-10-30
MA21735A1 (en) 1990-10-01
IE900225L (en) 1990-07-23
ATE82574T1 (en) 1992-12-15
EP0380217A1 (en) 1990-08-01
EG19306A (en) 1995-01-31
BA98302A (en) 2001-09-14
AP9000158A0 (en) 1990-01-31
KR900011774A (en) 1990-08-02
AU614214B2 (en) 1991-08-22
CS29990A3 (en) 1992-11-18
NO912863L (en) 1991-07-22
KR910009289B1 (en) 1991-11-09
ES2053094T3 (en) 1994-07-16
PT92919B (en) 1995-12-29
PT92919A (en) 1990-07-31
MY104861A (en) 1994-06-30
CA2008108C (en) 1995-08-08
IL93073A (en) 1994-05-30
WO1990008148A1 (en) 1990-07-26
SK279339B6 (en) 1998-10-07
BG51046A3 (en) 1993-01-15
GR3006925T3 (en) 1993-06-30
DK0380217T3 (en) 1992-12-14
ZA90430B (en) 1991-08-28
YU11190A (en) 1993-05-28
OA10041A (en) 1996-10-14
IS1667B (en) 1997-11-14
JPH02233681A (en) 1990-09-17
AP128A (en) 1991-03-20
FI95381B (en) 1995-10-13
YU47554B (en) 1995-10-03
JPH0643427B2 (en) 1994-06-08
NO175978B (en) 1994-10-03
FI95381C (en) 1996-01-25
IS3529A7 (en) 1990-07-24
NO912863D0 (en) 1991-07-22
CN1022186C (en) 1993-09-22
HU215154B (en) 2000-09-28
MX19222A (en) 1993-12-01
AR246969A1 (en) 1994-10-31
IE62670B1 (en) 1995-03-08
CA2008108A1 (en) 1990-07-23
HUT63163A (en) 1993-07-28
DE69000467D1 (en) 1992-12-24

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