NO166442C - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 8- (LOWER ALKYL) -BICYCLO- (4.2.0) -OCTANDER DERIVATIVES. - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 8- (LOWER ALKYL) -BICYCLO- (4.2.0) -OCTANDER DERIVATIVES.

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Publication number
NO166442C
NO166442C NO873131A NO873131A NO166442C NO 166442 C NO166442 C NO 166442C NO 873131 A NO873131 A NO 873131A NO 873131 A NO873131 A NO 873131A NO 166442 C NO166442 C NO 166442C
Authority
NO
Norway
Prior art keywords
lower alkyl
chem
octander
bicyclo
derivatives
Prior art date
Application number
NO873131A
Other languages
Norwegian (no)
Other versions
NO166442B (en
NO873131D0 (en
NO873131L (en
Inventor
Arthur F Kluge
Helen Yen-Hui Wu
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO873131D0 publication Critical patent/NO873131D0/en
Publication of NO873131L publication Critical patent/NO873131L/en
Publication of NO166442B publication Critical patent/NO166442B/en
Publication of NO166442C publication Critical patent/NO166442C/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/31—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system containing eight carbon atoms
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    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
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    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C07C403/16—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms not being part of —CHO groups
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    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
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    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
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    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
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    • C07C47/00—Compounds having —CHO groups
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    • C07C47/26—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups
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    • C07C49/233—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
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    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
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    • C07C2601/14—The ring being saturated

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Abstract

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension, and atherosclerosis and in inhibiting gastric acid secretion are compounds depicted in formulas (1), (2), and (3): <CHEM> wherein: Y is exo-(lower alkyl) or endo-(lower alkyl); n is 2 or 3; R1 is CH2OH, CHO, CO2R or CO2H; R2 is hydrogen or methyl; and R3 is linear or branched alkyl having 5-10 carbon atoms, <CHEM> optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, in which a is 0, 1 or 2; b is 3-7; m is 1 or 2; and R is <CHEM> wherein X is <CHEM> in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.
NO873131A 1986-07-28 1987-07-27 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 8- (LOWER ALKYL) -BICYCLO- (4.2.0) -OCTANDER DERIVATIVES. NO166442C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/891,509 US4678805A (en) 1985-03-27 1986-07-28 Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties

Publications (4)

Publication Number Publication Date
NO873131D0 NO873131D0 (en) 1987-07-27
NO873131L NO873131L (en) 1988-01-29
NO166442B NO166442B (en) 1991-04-15
NO166442C true NO166442C (en) 1991-07-24

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Application Number Title Priority Date Filing Date
NO873131A NO166442C (en) 1986-07-28 1987-07-27 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 8- (LOWER ALKYL) -BICYCLO- (4.2.0) -OCTANDER DERIVATIVES.

Country Status (16)

Country Link
US (1) US4678805A (en)
EP (1) EP0255098B1 (en)
JP (1) JPS6345232A (en)
KR (1) KR880001561A (en)
AT (1) ATE63899T1 (en)
AU (1) AU605493B2 (en)
DE (1) DE3770360D1 (en)
DK (1) DK391087A (en)
FI (1) FI873271A (en)
GR (1) GR3002024T3 (en)
HU (1) HU197870B (en)
IL (1) IL83339A0 (en)
NO (1) NO166442C (en)
NZ (1) NZ221197A (en)
PH (1) PH24200A (en)
ZA (1) ZA875513B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735966A (en) * 1986-08-25 1988-04-05 Syntex (U.S.A.) Inc. Novel substituted (4.2.0)bicyclooctane derivatives with valuable therapeutic properties
US5049497A (en) * 1986-08-25 1991-09-17 Syntex (U.S.A.) Inc. Novel process for the synthesis of the enantiomers of bicyclo(4.2.0)oct-2-en-7-one and derivatives
US4730078A (en) * 1987-05-13 1988-03-08 G. D. Searle & Co. Allenic prostacyclins
US4983627A (en) * 1988-11-10 1991-01-08 Syntex (U.S.A.) Inc. Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives
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PH24200A (en) 1990-04-10
HU197870B (en) 1989-06-28
FI873271A0 (en) 1987-07-27
JPS6345232A (en) 1988-02-26
AU7612587A (en) 1988-02-11
IL83339A0 (en) 1987-12-31
US4678805A (en) 1987-07-07
DK391087A (en) 1988-01-29
FI873271A (en) 1988-01-29
AU605493B2 (en) 1991-01-17
ZA875513B (en) 1989-03-29
EP0255098B1 (en) 1991-05-29
NO166442B (en) 1991-04-15
HUT44471A (en) 1988-03-28
DK391087D0 (en) 1987-07-27
KR880001561A (en) 1988-04-25
NO873131D0 (en) 1987-07-27
NO873131L (en) 1988-01-29
GR3002024T3 (en) 1992-12-30
ATE63899T1 (en) 1991-06-15
EP0255098A1 (en) 1988-02-03
DE3770360D1 (en) 1991-07-04
NZ221197A (en) 1990-01-29

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