NO148136B - PREPARATION FOR FIGHTING HEADLUSES, BODYLUSES AND SIMILAR SKIN PARASITES FOR TROPICAL USE - Google Patents
PREPARATION FOR FIGHTING HEADLUSES, BODYLUSES AND SIMILAR SKIN PARASITES FOR TROPICAL USEInfo
- Publication number
- NO148136B NO148136B NO782373A NO782373A NO148136B NO 148136 B NO148136 B NO 148136B NO 782373 A NO782373 A NO 782373A NO 782373 A NO782373 A NO 782373A NO 148136 B NO148136 B NO 148136B
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- anionic surfactant
- surfactant
- ionic
- similar skin
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 26
- 244000045947 parasite Species 0.000 title claims description 5
- 208000028454 lice infestation Diseases 0.000 claims description 11
- 239000002736 nonionic surfactant Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000003945 anionic surfactant Substances 0.000 claims description 8
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 7
- 244000060011 Cocos nucifera Species 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000004166 Lanolin Substances 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 7
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 claims description 7
- 229940039717 lanolin Drugs 0.000 claims description 7
- 235000019388 lanolin Nutrition 0.000 claims description 7
- 241000517307 Pediculus humanus Species 0.000 claims description 6
- 241000517324 Pediculidae Species 0.000 claims description 5
- 229960005286 carbaryl Drugs 0.000 claims description 5
- CVXBEEMKQHEXEN-UHFFFAOYSA-N carbaryl Chemical compound C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 CVXBEEMKQHEXEN-UHFFFAOYSA-N 0.000 claims description 5
- 239000000975 dye Substances 0.000 claims description 5
- 239000002798 polar solvent Substances 0.000 claims description 5
- 230000000699 topical effect Effects 0.000 claims description 5
- NPBHFKYMZPKJEO-UHFFFAOYSA-N 5-(butoxymethyl)-1,3-benzodioxole Chemical compound CCCCOCC1=CC=C2OCOC2=C1 NPBHFKYMZPKJEO-UHFFFAOYSA-N 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 description 16
- 239000000203 mixture Substances 0.000 description 12
- 239000004094 surface-active agent Substances 0.000 description 8
- 125000000129 anionic group Chemical group 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 206010010741 Conjunctivitis Diseases 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000012456 homogeneous solution Substances 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 239000005949 Malathion Substances 0.000 description 2
- -1 alkyl ether sulphate Chemical class 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229960000453 malathion Drugs 0.000 description 2
- 229960005235 piperonyl butoxide Drugs 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- FIPWRIJSWJWJAI-UHFFFAOYSA-N Butyl carbitol 6-propylpiperonyl ether Chemical compound C1=C(CCC)C(COCCOCCOCCCC)=CC2=C1OCO2 FIPWRIJSWJWJAI-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
Denne oppfinnelse angår et preparat for bekjempelse This invention relates to a preparation for fighting
av hodelus, kroppslus og lignende hudparasitter ved lokal applika- of head lice, body lice and similar skin parasites by local application
sjon på hud eller hår. tion on skin or hair.
De kjente kosmetiske geler er i alminnelighet hellbare The known cosmetic gels are generally pourable
geler som er dannet enten ved å tilsette et uorganisk salt til et alkylethersulfat eller ved at det i det kosmetiske preparat innlemmes cellulose, et alginat eller annet kjent, gummilignende fortykkningsmiddel. Disse kjente kosmetiske geler er vanlig- gels which are formed either by adding an inorganic salt to an alkyl ether sulphate or by incorporating cellulose, an alginate or other known rubber-like thickening agent into the cosmetic preparation. These known cosmetic gels are usually
vis badegeler som alt etter bruksområdet anvendes sammen med store mengder.vann, og som derfor ikke oppviser utpreget gelkonsistens innenfor et bredt område av omgivelsetemperaturer. show bath gels which, depending on the area of use, are used together with large quantities of water, and which therefore do not exhibit a distinct gel consistency within a wide range of ambient temperatures.
For bekjempelse av hodelus, Kroppslus og andre hudpara- For combating head lice, body lice and other skin para-
sitter har det vist seg ønskelig å behandle kroppen eller håret med et i vann uoppløselig aktivt stoff, f.eks. 1-nafthylmethyl- sitting, it has proved desirable to treat the body or hair with a water-insoluble active substance, e.g. 1-naphthylmethyl-
carbamat (carbaryl) , piperonyl- butoxyd og/eller et s-[ 1, 2-bis-(ethoxy-carbonyl)-ethyl]-0,0-dimethyldithiofosfat (malathion) eller corti-costeroid. For bekjempelse av hodelus og lignende er det i stor utstrekning blitt innlemmet aktive stoffer av denne type i kremer og salver for bruk i områder med temperert klima. I om- carbamate (carbaryl), piperonyl-butoxide and/or a s-[1, 2-bis-(ethoxy-carbonyl)-ethyl]-0,0-dimethyldithiophosphate (malathion) or corticosteroid. To combat head lice and the like, active substances of this type have largely been incorporated into creams and ointments for use in areas with a temperate climate. In about-
råder med tropisk klima vil imidlertid det anioniske overflate- prevails with a tropical climate, however, the anionic surface
aktive middel som i alminnelighet anvendes, såsom f.eks. natrium-laurylsulfat, oppløses i preparatet under dannelse av en væske i stedet for en krem. Ved senere avkjøling av preparatet krystall-iserer det overflateaktive middel ut av oppløsningen under dann- active agents that are generally used, such as e.g. sodium lauryl sulfate, dissolves in the preparation forming a liquid instead of a cream. Upon subsequent cooling of the preparation, the surface-active agent crystallizes out of the solution, forming
else av et produkt som inneholder korte nålelignende krystaller, other than a product containing short needle-like crystals,
som forstyrrer anvendelsen av det kosmetiske preparat. Fra US patentskrift nr. 3 352 753 er det kjent preparater for topisk anvendelse, som inneholder et corticoster6id som aktivt stoff, which interferes with the use of the cosmetic preparation. From US Patent No. 3 352 753 preparations for topical use are known, which contain a corticoster6id as active substance,
men som nå grunn av sitt høye innehold av polart oppløsningsmiddel f såsom vann eller ethylalkohol, taper sin gelkonsistens allerede ved temperaturer som ligger bare noe høyere enn vanlig romtemperatur slik at et preparat for topisk anvendelse som inneholder samme bærer som preparatet ifølge US patentskrift nr. 3 352 753, heller but which, due to its high content of polar solvent such as water or ethyl alcohol, loses its gel consistency already at temperatures that are only slightly higher than normal room temperature, so that a preparation for topical use containing the same carrier as the preparation according to US patent document no. 3 352 753, either
ikke vil være anvendelig i tropisk klima. will not be applicable in tropical climates.
Gelpreparater som er bestemt for annen administrering Gel preparations intended for other administration
enn topisk påføring, kan ikke anvendes topisk, da bestanddeler i disse irriterer huden og øynene og forårsaker konjunctivitis eller dermatitis. than topical application, cannot be used topically, as components in these irritate the skin and eyes and cause conjunctivitis or dermatitis.
Formålet med oppfinnelsen er å frembringe et preparat The purpose of the invention is to produce a preparation
for lokal applikasjon for bekjempelse av hodelus, kroppslus og lignende hudparasitter, hvilket preparat har en gelstruktur som bevares ved alle de temperaturer som kan være aktuelle ved normal bruk, og som kan påføres på huden hos mennesker eller dyr uten risiko for å irritere huden og øynene. for local application to combat head lice, body lice and similar skin parasites, which preparation has a gel structure that is preserved at all the temperatures that may be relevant in normal use, and which can be applied to the skin of humans or animals without the risk of irritating the skin and eyes .
I henhold tii oppfinnelsen tilveiebringes det således According to the invention it is thus provided
et preparat for bekjempelse av hodelus, kroppslus og lignende hudparasitter ved topisk anvendelse, hvilket preparat inneholder et anionaktivt, overflateaktivt stoff,ikke-ionogene overflateaktive stoffer, et polart oppløsningsmiddel og et aktivt stoff, såsom 1-nafthylmethylcarbamat, piperonylbutoxyd og/eller s-£i,2-bis-(ethoxycarbonyl)-ethyfj-0,O-dimethyl-dithiofosfat, og eventuelt farvestoffer og/eller luktstoffer. Det nye preparat ut-merker seg ved at det som anionaktivt, overflateaktivt stoff inneholder natriumlaurylethersulfat, som ikke-ionogene overflateaktive stoffer inneholder nonylfenoxypoly-(ethylenoxy)-ethanol, kokosnøttfettsyrediethanolamid og ethoxylert lanolin, og som polart oppløsningsmiddel inneholder vann, idet vektforholdet mellom anionaktivt, overflateaktivt stoff og ikke-ionogent overflateaktivt stoff er mellom 1:3 og 3:1, fortrinnsvis ca. 2:1, og at den totale mengde av anionaktivt, overflateaktivt stoff og ikke-ionogent overflateaktivt stoff utgjør mellom 20 og 60 vekt% av preparatet. a preparation for combating head lice, body lice and similar skin parasites by topical application, which preparation contains an anionic surface-active substance, non-ionic surfactants, a polar solvent and an active substance, such as 1-naphthylmethylcarbamate, piperonyl butoxyd and/or s-£ i,2-bis-(ethoxycarbonyl)-ethyl-O,O-dimethyl-dithiophosphate, and optionally dyes and/or odorants. The new preparation is distinguished by the fact that it contains sodium lauryl ether sulfate as an anionic surfactant, non-ionic surfactants contain nonylphenoxypoly-(ethyleneoxy)-ethanol, coconut fatty acid diethanolamide and ethoxylated lanolin, and as a polar solvent it contains water, since the weight ratio between anionic, surfactant and non-ionic surfactant is between 1:3 and 3:1, preferably approx. 2:1, and that the total amount of anionic surfactant and non-ionic surfactant constitutes between 20 and 60% by weight of the preparation.
Preparatet ifølge oppfinnelsen oppviser den fordel at overflateaktive midler og vannet som det inneholder ikke irriterer huden hos dyr eller mennesker og således ikke bevirker lidelser som dermatitis og konjunctivitis. The preparation according to the invention has the advantage that surfactants and the water it contains do not irritate the skin of animals or humans and thus do not cause disorders such as dermatitis and conjunctivitis.
Det antas at kombinasjonen av det anionaktiveoverflate-aktive middel med det ikke-ionogene overflateaktive middel i nær-vær av vann danner en co-micella-fase i oppløsningsmidlet som fører til geldannelse ved en økning i massevolumet av co-micella-fasen. Dette massevolum av de to overflateaktive midler bestemmer således geleringspunktet for preparatet, og det er av denne grunn at den foretrukne kombinerte prosent av det anion aktive overflateaktive middel og det ikke-ionooene overflateaktive middel i gelpreparatet ligger mellom 20 og 60 vekt%. It is believed that the combination of the anionic surfactant with the nonionic surfactant in the presence of water forms a co-micella phase in the solvent which leads to gel formation by an increase in the mass volume of the co-micella phase. This mass volume of the two surfactants thus determines the gelation point of the preparation, and it is for this reason that the preferred combined percentage of the anionic surfactant and the nonionic surfactant in the gel preparation is between 20 and 60% by weight.
Preparatet ifølge oppfinnelsen oppviser den fordel at de overflateaktive midler og vannet som det inneholder ikke irriterer huden hos dyr eller mennesker og således ikke bevirker lidelser som dermatitis og konjuntivitis. Preparatet ifølge oppfinnelsen kan med fordel fremstilles ved at det anionaktive, overflateaktive stoff i form av en pasta oppvarmes med det ikke-ion overflateaktive stoff, det aktive stoff oppløses i det overflateaktive stoff som det er oppløselig i, vannet tilsettes, og det hele omrøres inntil det er dannet en klar oppløsning, hvoretter det foretas avkjøling. The preparation according to the invention has the advantage that the surfactants and the water it contains do not irritate the skin of animals or humans and thus do not cause disorders such as dermatitis and conjunctivitis. The preparation according to the invention can advantageously be prepared by heating the anionic surface-active substance in the form of a paste with the non-ionic surfactant, the active substance is dissolved in the surfactant in which it is soluble, the water is added, and the whole is stirred until a clear solution is formed, after which cooling is carried out.
De følgende eksempler illustrerer oppfinnelsen. The following examples illustrate the invention.
Eksempel 1 Example 1
Natriuralaurylethersulfatet, kokos nøtt -diethanolamidet og Sodium lauryl ether sulfate, coconut diethanolamide and
det ethoxylerte lanolin blandes sammen ved en temperatur på 70 - 80 oC. Carbarylet oppløses i nonylfenoxypoly-(ethylenoxy)-ethanolen the ethoxylated lanolin is mixed together at a temperature of 70 - 80 oC. The carbaryl dissolves in the nonylphenoxypoly-(ethyleneoxy)-ethanol
ved oppvarmning til en temperatur på 40 - 50°C. Blandingen om-røres for å danne en klar oppløsning. Den erholdte oppløsning tilsettes til blandingen av natriumlaurylethersul fat, kokosnøtt-diethanolamidet og det ethoxylerte lanolin, og omrøres for å by heating to a temperature of 40 - 50°C. The mixture is stirred to form a clear solution. The resulting solution is added to the mixture of sodium lauryl ether sulfate, the coconut diethanolamide and the ethoxylated lanolin, and stirred to
danne en homogen oppløsning. form a homogeneous solution.
Farvestoffet oppløses fullstendig i den beregnede menger The dye dissolves completely in the calculated amount
vann, og den dannede oppløsning oppvarmes til en temperatur like under kokepunktet og tilsettes så langsomt til den ovenfor fremstilte homogene oppløsning. Den dannede blanding holdes ved en høy temperatur for å tillate luft å unnslippe. Blandingen av-kjøles så til 55 - 6o°C, og parfyme innrøres langsomt. Ved av-kjøling til værelsetemperatur dannes en gel som bibeholder sin geltilstand og foo i minst 2 år når den lagres ved værelsetemperatur eller 30°C. water, and the resulting solution is heated to a temperature just below the boiling point and then slowly added to the homogenous solution prepared above. The resulting mixture is kept at a high temperature to allow air to escape. The mixture is then cooled to 55 - 6o°C, and perfume is slowly stirred in. Upon cooling to room temperature, a gel is formed which retains its gel state and foo for at least 2 years when stored at room temperature or 30°C.
Eksempel 2 Example 2
Natriumlaurylethersulfatet, kokosnøtt-diethanolamidet og det ethoxylerte lanolin blandes sammen ved en temperatur på 70 - 80°C . Nonylfenoxypoly-(ethylenoxy)-ethanolen tilsettes så til blandingen som omrøres for å danne en homogen oppløsning. Farvestoffet oppløses fullstendig i den beregnede mengde vann, og den erholdte oppløsning oppvarmes til en temperatur like under kokepunktet og tilsettes så langsomt til den ovenfor fremstilte homogene oppløsning. The sodium lauryl ether sulfate, the coconut diethanolamide and the ethoxylated lanolin are mixed together at a temperature of 70 - 80°C. The nonylphenoxypoly-(ethyleneoxy)-ethanol is then added to the mixture which is stirred to form a homogeneous solution. The dye is completely dissolved in the calculated amount of water, and the resulting solution is heated to a temperature just below the boiling point and then slowly added to the homogenous solution prepared above.
Den dannede blanding holdes ved en høy temperatur for å tillate lu^t å unnslippe. Blandingen avkjøles så til 55 - 60°C og innstilles på pH 5,2 med fortynnet saltsyre. Malathionet og parfymen røres så langsomt inn i blandingen. Ved avkjøling til værelsetemperatur dannes en gel som bibeholder sin gelstruktur og fonn når den oppvarmes til en temperatur på minst 30°C. The resulting mixture is kept at a high temperature to allow air to escape. The mixture is then cooled to 55 - 60°C and adjusted to pH 5.2 with dilute hydrochloric acid. The malathion and the perfume are then slowly stirred into the mixture. When cooled to room temperature, a gel is formed which retains its gel structure and shape when heated to a temperature of at least 30°C.
Natriumlaurylethersulfatet, kokosnøtt-diethanolamidet og det ethoxylerte lanolin blandes sammen ved en temperatur på 70 - 80°C. Carbarylet, piperony1-butoxydet og isopropyl-myristatet oppløses i nonylfenoxypoly-(ethylenoxy)-ethanolen ved oppvarmning til en temperatur på ZfO - 50°C. Blandingen omrøres for å danne en klar oppløsning. The sodium lauryl ether sulfate, the coconut diethanolamide and the ethoxylated lanolin are mixed together at a temperature of 70 - 80°C. The carbaryl, the piperony-1-butoxide and the isopropyl myristate are dissolved in the nonylphenoxypoly-(ethyleneoxy)-ethanol by heating to a temperature of ZfO - 50°C. The mixture is stirred to form a clear solution.
Den erholdte oppløsning tilsettes til blandingen av natrium-laurylethersulf at , kokosnøtt-diethanolamidet og det ethoxylerte lanolin og omrøres for å danne en homogen oppløsning. Farvestoffet oppløses fullstendig i den beregnede mengde vann, og den erholdte oppløsning oppvarmes til en temperatur like under kokepunktet og tilsettes så langsomt til den ovenfor fremstilte homogene oppløsning. Den erholdte blanding holdes ved en høy temperatur for å tillate luft å unnslippe. Blandingen avkjøles så til 55 - 6o°C, og parfymen innrøres langsomt. The resulting solution is added to the mixture of sodium lauryl ether sulfate, the coconut diethanolamide and the ethoxylated lanolin and stirred to form a homogeneous solution. The dye is completely dissolved in the calculated amount of water, and the resulting solution is heated to a temperature just below the boiling point and then slowly added to the homogenous solution prepared above. The resulting mixture is kept at a high temperature to allow air to escape. The mixture is then cooled to 55 - 6o°C, and the perfume is slowly stirred in.
Ved avkjøling til værelsetemperatur dannes en gel som bibeholder sine gelegenskape 1: og form når den oppvarmes til en temperatur på minst 30°C. When cooled to room temperature, a gel is formed which retains its gel properties 1: and shape when heated to a temperature of at least 30°C.
Claims (3)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2872277 | 1977-07-08 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO782373L NO782373L (en) | 1979-01-09 |
NO148136B true NO148136B (en) | 1983-05-09 |
NO148136C NO148136C (en) | 1983-08-17 |
Family
ID=10280057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO782373A NO148136C (en) | 1977-07-08 | 1978-07-07 | PREPARATION FOR COMBATING HEADLUSES, BODYLUSES AND SIMILAR SKIN PARASITES FOR TROPICAL USE |
Country Status (13)
Country | Link |
---|---|
AR (1) | AR222305A1 (en) |
BE (1) | BE868239A (en) |
CA (1) | CA1099637A (en) |
DK (1) | DK306678A (en) |
FI (1) | FI70136C (en) |
FR (1) | FR2396546A1 (en) |
GR (1) | GR65307B (en) |
IL (1) | IL54972A (en) |
MX (1) | MX5148E (en) |
NL (1) | NL7805745A (en) |
NO (1) | NO148136C (en) |
PT (1) | PT68078B (en) |
SE (1) | SE7806690L (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6265384B1 (en) | 1999-01-26 | 2001-07-24 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE932516C (en) * | 1943-02-07 | 1955-09-01 | Dehydag Gmbh | Process for the production of jelly-like preparations |
BE565499A (en) * | 1957-03-07 | |||
FR1365793A (en) * | 1963-08-08 | 1964-07-03 | Shiseido Co Ltd | Process for preparing jelly-like toilet articles and articles obtained by this process |
DE2436028C3 (en) * | 1974-07-26 | 1980-08-21 | Eduard Gerlach Gmbh Chemische Fabrik, 4990 Luebbecke | Use of diethylene glycol to destroy lice and their eggs / nits Eduard Gerlach GmbH Chemische Fabrik, 4990 Lübbecke |
JPS5235204A (en) * | 1975-09-16 | 1977-03-17 | Kao Corp | Clear high viscous liuid shampoo composition |
-
1978
- 1978-05-11 GR GR56209A patent/GR65307B/en unknown
- 1978-05-19 AR AR272241A patent/AR222305A1/en active
- 1978-05-24 PT PT68078A patent/PT68078B/en unknown
- 1978-05-26 NL NL7805745A patent/NL7805745A/en not_active Application Discontinuation
- 1978-06-07 FI FI781815A patent/FI70136C/en not_active IP Right Cessation
- 1978-06-08 SE SE7806690A patent/SE7806690L/en unknown
- 1978-06-19 BE BE188666A patent/BE868239A/en not_active IP Right Cessation
- 1978-06-21 CA CA305,913A patent/CA1099637A/en not_active Expired
- 1978-06-22 IL IL54972A patent/IL54972A/en unknown
- 1978-07-05 MX MX787205U patent/MX5148E/en unknown
- 1978-07-07 DK DK783066A patent/DK306678A/en unknown
- 1978-07-07 NO NO782373A patent/NO148136C/en unknown
- 1978-07-07 FR FR7820324A patent/FR2396546A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
GR65307B (en) | 1980-08-01 |
IL54972A (en) | 1981-11-30 |
MX5148E (en) | 1983-04-04 |
IL54972A0 (en) | 1978-08-31 |
FI70136C (en) | 1986-09-15 |
FI781815A (en) | 1979-01-09 |
NO782373L (en) | 1979-01-09 |
DK306678A (en) | 1979-01-09 |
AR222305A1 (en) | 1981-05-15 |
CA1099637A (en) | 1981-04-21 |
NL7805745A (en) | 1979-01-10 |
FR2396546A1 (en) | 1979-02-02 |
FI70136B (en) | 1986-02-28 |
NO148136C (en) | 1983-08-17 |
BE868239A (en) | 1978-10-16 |
PT68078B (en) | 1979-11-21 |
FR2396546B1 (en) | 1983-07-29 |
SE7806690L (en) | 1979-01-09 |
PT68078A (en) | 1978-06-01 |
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