NO127694B - - Google Patents
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- Publication number
- NO127694B NO127694B NO03396/68A NO339668A NO127694B NO 127694 B NO127694 B NO 127694B NO 03396/68 A NO03396/68 A NO 03396/68A NO 339668 A NO339668 A NO 339668A NO 127694 B NO127694 B NO 127694B
- Authority
- NO
- Norway
- Prior art keywords
- protodyne
- protoplasm
- extraction
- bacterial
- cells
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 claims description 18
- 108010015658 protodyne Proteins 0.000 claims description 17
- 238000000605 extraction Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 9
- 230000001580 bacterial effect Effects 0.000 claims description 9
- 241000894006 Bacteria Species 0.000 claims description 8
- 210000000805 cytoplasm Anatomy 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- 210000002421 cell wall Anatomy 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 206010037660 Pyrexia Diseases 0.000 claims description 4
- 231100000419 toxicity Toxicity 0.000 claims description 4
- 230000001988 toxicity Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 5
- 239000002158 endotoxin Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229910021536 Zeolite Inorganic materials 0.000 description 3
- 235000021588 free fatty acids Nutrition 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 239000010457 zeolite Substances 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 241000607715 Serratia marcescens Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- YRTWNFXASSUQEW-UHFFFAOYSA-M sodium;methanol;acetate Chemical class [Na+].OC.CC([O-])=O YRTWNFXASSUQEW-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67774267A | 1967-10-24 | 1967-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO127694B true NO127694B (de) | 1973-08-06 |
Family
ID=24719946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO03396/68A NO127694B (de) | 1967-10-24 | 1968-08-31 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3483290A (de) |
| JP (1) | JPS507130B1 (de) |
| AT (1) | AT287194B (de) |
| BE (1) | BE722736A (de) |
| CH (1) | CH560542A5 (de) |
| DE (1) | DE1767793A1 (de) |
| DK (1) | DK122008B (de) |
| ES (1) | ES357845A1 (de) |
| FI (1) | FI44270C (de) |
| FR (1) | FR1604222A (de) |
| GB (1) | GB1217753A (de) |
| IE (1) | IE32427B1 (de) |
| IL (1) | IL30664A (de) |
| IN (1) | IN117571B (de) |
| LU (1) | LU56854A1 (de) |
| NL (1) | NL6813299A (de) |
| NO (1) | NO127694B (de) |
| SE (1) | SE359446B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1281844A (en) * | 1970-04-11 | 1972-07-19 | Beecham Group Ltd | Method of separating allergenic material |
| FR2374042A1 (fr) * | 1976-06-04 | 1978-07-13 | Merieux Inst | Nouveau medicament immunostimulant et son procede de preparation |
| US4220584A (en) * | 1978-01-30 | 1980-09-02 | Merck & Co., Inc. | E. coli enterotoxin vaccine for veterinary and human use |
| US4285931A (en) * | 1978-01-30 | 1981-08-25 | Merck & Co., Inc. | E. coli enterotoxin vaccine for veterinary and human use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2340318A (en) * | 1941-07-19 | 1944-02-01 | Squibb & Sons Inc | Process of fractionating mixtures of bacterial origin |
| US3148120A (en) * | 1952-01-24 | 1964-09-08 | Wander Ag Dr A | Hot aqueous phenol extraction of gramnegative bacterial lipopolysaccharides |
| US3089821A (en) * | 1959-10-28 | 1963-05-14 | Merck & Co Inc | Process for the preparation of lipids |
| US3119741A (en) * | 1962-04-10 | 1964-01-28 | Princeton Lab Inc | Non-specific immunizing agent |
| US3132995A (en) * | 1961-10-20 | 1964-05-12 | Carter Prod Inc | Endotoxin fractions and method for producing same |
| GB1056839A (en) * | 1963-09-19 | 1967-02-01 | Johnson & Johnson | Brucella antigen |
-
1967
- 1967-10-24 US US677742A patent/US3483290A/en not_active Expired - Lifetime
-
1968
- 1968-06-19 DE DE19681767793 patent/DE1767793A1/de active Pending
- 1968-08-27 ES ES357845A patent/ES357845A1/es not_active Expired
- 1968-08-30 CH CH1305668A patent/CH560542A5/xx not_active IP Right Cessation
- 1968-08-30 AT AT847268A patent/AT287194B/de not_active IP Right Cessation
- 1968-08-31 NO NO03396/68A patent/NO127694B/no unknown
- 1968-09-04 IL IL30664A patent/IL30664A/en unknown
- 1968-09-05 IN IN117571A patent/IN117571B/en unknown
- 1968-09-10 LU LU56854D patent/LU56854A1/xx unknown
- 1968-09-11 JP JP43064972A patent/JPS507130B1/ja active Pending
- 1968-09-12 FI FI682559A patent/FI44270C/fi active
- 1968-09-18 NL NL6813299A patent/NL6813299A/xx unknown
- 1968-09-25 DK DK462068AA patent/DK122008B/da unknown
- 1968-09-26 SE SE12967/68A patent/SE359446B/xx unknown
- 1968-10-21 GB GB49812/68A patent/GB1217753A/en not_active Expired
- 1968-10-21 IE IE1264/68A patent/IE32427B1/xx unknown
- 1968-10-22 FR FR1604222D patent/FR1604222A/fr not_active Expired
- 1968-10-23 BE BE722736D patent/BE722736A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES357845A1 (es) | 1970-03-16 |
| LU56854A1 (de) | 1968-12-17 |
| FI44270B (de) | 1971-06-30 |
| DK122008B (da) | 1972-01-03 |
| US3483290A (en) | 1969-12-09 |
| FR1604222A (de) | 1971-10-04 |
| IN117571B (de) | 1975-09-20 |
| DE1767793A1 (de) | 1971-09-30 |
| IL30664A (en) | 1972-06-28 |
| FI44270C (fi) | 1971-10-11 |
| JPS507130B1 (de) | 1975-03-22 |
| NL6813299A (de) | 1969-04-28 |
| IE32427B1 (en) | 1973-07-25 |
| IE32427L (en) | 1969-04-24 |
| CH560542A5 (de) | 1975-04-15 |
| IL30664A0 (en) | 1968-11-27 |
| GB1217753A (en) | 1970-12-31 |
| BE722736A (de) | 1969-04-01 |
| AT287194B (de) | 1971-01-11 |
| SE359446B (de) | 1973-09-03 |
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