NL7713938A - Treating mycoplasma infections in plants and animals - with copper complexes of isoquinoline, quinazoline and phenanthroline - Google Patents
Treating mycoplasma infections in plants and animals - with copper complexes of isoquinoline, quinazoline and phenanthrolineInfo
- Publication number
- NL7713938A NL7713938A NL7713938A NL7713938A NL7713938A NL 7713938 A NL7713938 A NL 7713938A NL 7713938 A NL7713938 A NL 7713938A NL 7713938 A NL7713938 A NL 7713938A NL 7713938 A NL7713938 A NL 7713938A
- Authority
- NL
- Netherlands
- Prior art keywords
- lower alkyl
- halo
- alkyl
- phenanthroline
- quinazoline
- Prior art date
Links
- 206010028470 Mycoplasma infections Diseases 0.000 title abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 2
- 241001465754 Metazoa Species 0.000 title 1
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 title 1
- 150000001879 copper Chemical class 0.000 title 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 241000192125 Firmicutes Species 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 241001502500 Trichomonadida Species 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 abstract 1
- 229960000268 spectinomycin Drugs 0.000 abstract 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/005—Compounds containing elements of Groups 1 or 11 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/08—Copper compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Mycoplasma infections are treated by using a complex of a Cu salt (III), having an acceptable anion, plus a cpd. (I) or (II) as ligand. In (I), A is N or Cr; R is H or 1-12C alkyl; B is 2-R1-pyrid-6-yl (Ia) or 1-R15-5-R16-imidazol-2-yl (Ib); R1 is H or lower alkyl; R15 is H, or lower alkyl or alkenyl; R16 is H or NO2; R2 is H, halo, lower alkyl, phenyl, NH2 (opt. mono-or di-lower alkyl substd.) but is H, halo, CH3 or opt. substd. NH2 when A is N and/or B is (Ib); R3 and R6 are each H, halo or lower alkyl; R4 and R5 are each H, halo, is not >12C alkyl or lower alkoxy; R7 and R14 are each H, halo (esp. Cl), lower alkyl or alkoxy or NH2; each of R8 to R13 is H, lower alkyl. Specific (I) is bis-(2,9-dimethyl-1,10-phenantholine)-CuNO3 complex. They are effective against species resistant to tylosine and spectinomycin and also have activity against Gram-positive bacteria, fungi yeasts, mycobacteria and trichomonads. (I) where B is (Ib) and R2 is NH2 are useful as antihypertensives.
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7713938A NL7713938A (en) | 1977-12-15 | 1977-12-15 | Treating mycoplasma infections in plants and animals - with copper complexes of isoquinoline, quinazoline and phenanthroline |
| DE19782826526 DE2826526A1 (en) | 1977-06-17 | 1978-06-16 | COPPER COMPLEXES OF PHENANTHROLIN, ISOCHINOLINE AND QUINAZOLINE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE IN THE CONTROL OF MYCOPLASMA INFECTIONS |
| GB7827117A GB2002746A (en) | 1977-06-17 | 1978-06-16 | Copper complexes |
| JP7366378A JPS54119479A (en) | 1977-06-17 | 1978-06-17 | Copper complex |
| US05/916,541 US4269834A (en) | 1977-06-17 | 1978-06-19 | Copper complexes of isoquinazolines |
| DK275078A DK275078A (en) | 1977-06-17 | 1978-06-19 | COPPER COMPLEX |
| NL7806573A NL7806573A (en) | 1977-06-17 | 1978-06-19 | PREPARATIONS WITH MEDICINAL EFFICACY. |
| SE7807001A SE7807001L (en) | 1977-06-17 | 1978-06-19 | COPPER COMPLEX |
| IT7868424A IT7868424A0 (en) | 1977-06-17 | 1978-06-19 | COPPER COMPLEXES PARTICULARLY USEFUL AGAINST DISEASES PRODUCED BY MICROPLASMS AND PROCEDURE FOR THEIR PREPARATION |
| CA305,746A CA1102329A (en) | 1977-06-17 | 1978-06-19 | Process for the preparation of new therapeutically useful isoquinoline and quinazoline derivatives |
| FR7818282A FR2401155A1 (en) | 1977-06-17 | 1978-06-19 | COPPER COMPLEXES, THEIR PREPARATION PROCESS AND THEIR USE AS ANTIMYCOTICS |
| LU79832A LU79832A1 (en) | 1977-06-17 | 1978-06-19 | COPPER COMPLEXES |
| FR7906395A FR2422659A1 (en) | 1977-06-17 | 1979-03-13 | COMPOUNDS BELONGING TO THE ISOQUINOLEINE AND SUBSTITUTED QUINAZOLINE FAMILY, THEIR METHOD OF PREPARATION AND THEIR USE IN THERAPEUTICS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7713938A NL7713938A (en) | 1977-12-15 | 1977-12-15 | Treating mycoplasma infections in plants and animals - with copper complexes of isoquinoline, quinazoline and phenanthroline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7713938A true NL7713938A (en) | 1979-06-19 |
Family
ID=19829772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7713938A NL7713938A (en) | 1977-06-17 | 1977-12-15 | Treating mycoplasma infections in plants and animals - with copper complexes of isoquinoline, quinazoline and phenanthroline |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL7713938A (en) |
-
1977
- 1977-12-15 NL NL7713938A patent/NL7713938A/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |