NL7713422A - Determination of blood heparin concn. - by rapid, sensitive and accurate method using heparin as anticoagulant - Google Patents

Determination of blood heparin concn. - by rapid, sensitive and accurate method using heparin as anticoagulant

Info

Publication number
NL7713422A
NL7713422A NL7713422A NL7713422A NL7713422A NL 7713422 A NL7713422 A NL 7713422A NL 7713422 A NL7713422 A NL 7713422A NL 7713422 A NL7713422 A NL 7713422A NL 7713422 A NL7713422 A NL 7713422A
Authority
NL
Netherlands
Prior art keywords
heparin
blood
thrombin
reaction
concn
Prior art date
Application number
NL7713422A
Other languages
Dutch (nl)
Original Assignee
Jean Innerfield H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jean Innerfield H filed Critical Jean Innerfield H
Priority to NL7713422A priority Critical patent/NL7713422A/en
Publication of NL7713422A publication Critical patent/NL7713422A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Blood heparin concns. in heparinised patients are determined by adding serum from the blood to standardised thrombin soln. and incubating the mixt. at a selected temp. for a defined period (too short for reaction between thrombin and any fibrin degradation prod. but sufficient for reaction between thrombin and heparin). A standard portion of the mixture is then added to normal plasma that has been equilibrated at the same selected temp. The clotting time of the resulting mixture is observed; it is an inverse function of the amt. of thrombin left after reaction with heparin and is a direct function of blood heparin. The clotting time is compared with standard curves prepd. by using serum from healthy individuals to whch standard amts. of heparin had been added. Rapid, sensitive and reliable method for determining heparin in blood to give accurate monitoring when heparin is used as an anticoagulant. The relationship between heparin content and the concn. of antithrombin III can be drawn.
NL7713422A 1977-12-05 1977-12-05 Determination of blood heparin concn. - by rapid, sensitive and accurate method using heparin as anticoagulant NL7713422A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7713422A NL7713422A (en) 1977-12-05 1977-12-05 Determination of blood heparin concn. - by rapid, sensitive and accurate method using heparin as anticoagulant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7713422A NL7713422A (en) 1977-12-05 1977-12-05 Determination of blood heparin concn. - by rapid, sensitive and accurate method using heparin as anticoagulant

Publications (1)

Publication Number Publication Date
NL7713422A true NL7713422A (en) 1979-06-07

Family

ID=19829688

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7713422A NL7713422A (en) 1977-12-05 1977-12-05 Determination of blood heparin concn. - by rapid, sensitive and accurate method using heparin as anticoagulant

Country Status (1)

Country Link
NL (1) NL7713422A (en)

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Legal Events

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