NL7506570A - Pyrazolo-benzazepine derivs - useful as antidepressants of the imipramine type - Google Patents

Pyrazolo-benzazepine derivs - useful as antidepressants of the imipramine type

Info

Publication number
NL7506570A
NL7506570A NL7506570A NL7506570A NL7506570A NL 7506570 A NL7506570 A NL 7506570A NL 7506570 A NL7506570 A NL 7506570A NL 7506570 A NL7506570 A NL 7506570A NL 7506570 A NL7506570 A NL 7506570A
Authority
NL
Netherlands
Prior art keywords
antidepressants
derivs
benzazepine
pyrazolo
useful
Prior art date
Application number
NL7506570A
Other languages
Dutch (nl)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of NL7506570A publication Critical patent/NL7506570A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of formula (I) and (II) and their N-oxides are new, (where A is 1, 2-phenylene; Ar is monocyclic carbocyclic aryl; R0 is H, lower alkyl, (hydroxy, lower alkoxy or D)-CmH2m Ar-CnH2n, lower alkanoyl, lower alkoxy-carbonyl, D-CO, D-CS or cyano; D is amino; m is 1-7; n is 0-7; R1 and R2 are H or lower alkyl; R3 is H, lower alkyl, OH or lower alkanoyl-oxy). Inters. in the prepn. of (I) and (II) are also new. (I) and (II) are antidepressants of the imipramine type and exert anxiolytic activity over long periods. Dosages are 0.1-300, pref. 2-20 mg./kg./day.
NL7506570A 1974-06-03 1975-06-03 Pyrazolo-benzazepine derivs - useful as antidepressants of the imipramine type NL7506570A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH475474 1974-06-03

Publications (1)

Publication Number Publication Date
NL7506570A true NL7506570A (en) 1975-12-05

Family

ID=4281918

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7506570A NL7506570A (en) 1974-06-03 1975-06-03 Pyrazolo-benzazepine derivs - useful as antidepressants of the imipramine type

Country Status (1)

Country Link
NL (1) NL7506570A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014454A2 (en) * 1979-02-07 1980-08-20 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process and intermediates for the preparation of 2-benzazepine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014454A2 (en) * 1979-02-07 1980-08-20 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Process and intermediates for the preparation of 2-benzazepine derivatives
EP0014454A3 (en) * 1979-02-07 1980-10-15 F. Hoffmann-La Roche & Co. Aktiengesellschaft Process and intermediates for the preparation of 2-benzazepine derivatives

Similar Documents

Publication Publication Date Title
ES433217A1 (en) Assembly with relatively displaceable members
GB1385342A (en) Ligand determination of spin labelled compounds by receptor displacement
GB1426645A (en) Pipstick and similar holder
HU174541B (en) Combined fast-closing and regulating valve
CA1025906A (en) Latch and lock structure
DE69427706D1 (en) Cryptophycine
CA986159A (en) Security system and lock therefor
ES409567A1 (en) 1,3-Diphenyl-propanone-1-derivatives and the salts thereof
NL7506570A (en) Pyrazolo-benzazepine derivs - useful as antidepressants of the imipramine type
CA990310A (en) Preparation of d,d'-2,2'-(ethylenediimino)di-1-butanol hydrochloride
GB1471980A (en) Laundry system
ES2001783A6 (en) Macrocyclic antibiotics.
Piersol THE OETTINGEN-WALLERSTEIN HOFKAPELLE AND ITS WIND MUSIC.(VOLUMES I AND II)
IE40850B1 (en) 7-methoxycephalosporins
FR2073240A1 (en) Cold creams with pineapple - or ginseng extracts with cosmetic and therapeutic value
HK57477A (en) 3'-4'-dideoxykanamycin b active against resistant bacteria, and its synthesis
FR2213068A1 (en) UV filter contg. 3-carboxy-4-hydroxy-benzophenone - prepd. by Friedel-Crafts reaction using benzoyl chloride
GB1429423A (en) Lokcing key
FR2183578A2 (en) Yohimbine phenyl hydrazides - prepd from yohimbic hydrazide and a benz-aldehyde, useful hypotensives and cardiac stimulants
FR2222095A1 (en) 3-Substd. tetrahydro-benzopyrano (3,4-c) pyridin-5-ones - bronchodilators for treating bronchial asthma
USD232806S (en) Key blank
CA989271A (en) Combination backflow preventer and antisiphon valve
FR2201086A1 (en) Ammonium nitrate medicament - for treating acne, baldness, sunstroke, wrinkles and mycosis
FR2120916A5 (en) Carburised titanium optitanium alloy - for abrasion resistant watch straps
GB1383060A (en) Glazing inserts