NL7308463A - Organogermanium cpds. from dialkylgermanium hydrides - and alkylenically unsatd. cpds., inters for physiological or chemotherapeutic cpds. - Google Patents
Organogermanium cpds. from dialkylgermanium hydrides - and alkylenically unsatd. cpds., inters for physiological or chemotherapeutic cpds.Info
- Publication number
- NL7308463A NL7308463A NL7308463A NL7308463A NL7308463A NL 7308463 A NL7308463 A NL 7308463A NL 7308463 A NL7308463 A NL 7308463A NL 7308463 A NL7308463 A NL 7308463A NL 7308463 A NL7308463 A NL 7308463A
- Authority
- NL
- Netherlands
- Prior art keywords
- cpds
- unsatd
- cpd
- dialkylgermanium
- inters
- Prior art date
Links
- 230000000973 chemotherapeutic effect Effects 0.000 title abstract 2
- 150000004678 hydrides Chemical class 0.000 title abstract 2
- 125000000082 organogermanium group Chemical group 0.000 title 1
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- ZFDIRQKJPRINOQ-HWKANZROSA-N Ethyl crotonate Chemical compound CCOC(=O)\C=C\C ZFDIRQKJPRINOQ-HWKANZROSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003999 initiator Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- ZFDIRQKJPRINOQ-UHFFFAOYSA-N transbutenic acid ethyl ester Natural products CCOC(=O)C=CC ZFDIRQKJPRINOQ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/30—Germanium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
Abstract
Title cpds. are prepd. by reacting dialkylgermanium hydrides (alkyl)2GeH2 with an alpha, beta-unsatd. cpd. contg. =C=C=, in the presence of a free radical initiator such as azobisisobutyronitrile or UV light. Reaction is generally carried out by adding the unsatd. cpd. (e.g. methyl(meth) acrylate or ethylcrotonate) to the refluxing Ge cpd. so that the concn. of the unsatd. cpd. remains low during the addn. Prods. are useful inters. e.g. in the prodn. of Ge-contg. cpds. with physiological or chemotherapeutic props. such as di- or tricyclic azaspiranes having a Ge atom in the ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7308463A NL7308463A (en) | 1973-06-18 | 1973-06-18 | Organogermanium cpds. from dialkylgermanium hydrides - and alkylenically unsatd. cpds., inters for physiological or chemotherapeutic cpds. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7308463A NL7308463A (en) | 1973-06-18 | 1973-06-18 | Organogermanium cpds. from dialkylgermanium hydrides - and alkylenically unsatd. cpds., inters for physiological or chemotherapeutic cpds. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7308463A true NL7308463A (en) | 1974-12-20 |
Family
ID=19819107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7308463A NL7308463A (en) | 1973-06-18 | 1973-06-18 | Organogermanium cpds. from dialkylgermanium hydrides - and alkylenically unsatd. cpds., inters for physiological or chemotherapeutic cpds. |
Country Status (1)
| Country | Link |
|---|---|
| NL (1) | NL7308463A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2227487A (en) * | 1989-01-30 | 1990-08-01 | Asai Germanium Res Inst | Organogermanium compounds for inhibiting the activity of opioid peptide-degrading enzyme |
-
1973
- 1973-06-18 NL NL7308463A patent/NL7308463A/en not_active Application Discontinuation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2227487A (en) * | 1989-01-30 | 1990-08-01 | Asai Germanium Res Inst | Organogermanium compounds for inhibiting the activity of opioid peptide-degrading enzyme |
| US5041577A (en) * | 1989-01-30 | 1991-08-20 | Asai Germanium Research Institute Co., Ltd. | Organogermanium compounds, processes for producing the same, and agent for inhibiting the activity of opioid peptide-degrading enzyme |
| GB2227487B (en) * | 1989-01-30 | 1992-04-29 | Asai Germanium Res Inst | Organogermanium compounds, processes for producing the same, and agent for inhibiting the activity of opioid peptide-degrading enzyme |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BV | The patent application has lapsed |