NL7102715A - Phenyl-or thienyl-alkylidene amino-oxy-alkanoic acid basic esters - - as anti-inflammatory agents and analgesics - Google Patents

Phenyl-or thienyl-alkylidene amino-oxy-alkanoic acid basic esters - - as anti-inflammatory agents and analgesics

Info

Publication number
NL7102715A
NL7102715A NL7102715A NL7102715A NL7102715A NL 7102715 A NL7102715 A NL 7102715A NL 7102715 A NL7102715 A NL 7102715A NL 7102715 A NL7102715 A NL 7102715A NL 7102715 A NL7102715 A NL 7102715A
Authority
NL
Netherlands
Prior art keywords
phenyl
opt
analgesics
thienyl
oxy
Prior art date
Application number
NL7102715A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AR236029A priority Critical patent/AR205682A1/en
Application filed filed Critical
Priority to NL7102715A priority patent/NL7102715A/en
Priority to AT494571A priority patent/AT313254B/en
Priority to AT1110172A priority patent/AT313255B/en
Priority to GB1941671*[A priority patent/GB1325231A/en
Priority to CH680874A priority patent/CH571481A5/xx
Priority to AT1110372A priority patent/AT313256B/en
Priority to CH829871A priority patent/CH561179A5/xx
Priority to CH680974A priority patent/CH571482A5/xx
Priority to AT1110472A priority patent/AT313875B/en
Priority to CA115,079A priority patent/CA947763A/en
Priority to SE7107416A priority patent/SE401177B/en
Priority to DE2128375A priority patent/DE2128375C3/en
Priority to CH680774A priority patent/CH568968A5/xx
Priority to MX002414U priority patent/MX3034E/en
Priority to DK278271AA priority patent/DK129513B/en
Priority to MX002463U priority patent/MX3077E/en
Priority to BE768321A priority patent/BE768321A/en
Priority to ES392072A priority patent/ES392072A1/en
Priority to JP4026971A priority patent/JPS549186B1/ja
Priority to IL37013A priority patent/IL37013A/en
Priority to US00151793A priority patent/US3853955A/en
Priority to FR7121298A priority patent/FR2100751B1/fr
Publication of NL7102715A publication Critical patent/NL7102715A/en
Priority to AR249269A priority patent/AR197517A1/en
Priority to AR249270A priority patent/AR197623A1/en
Priority to AR249271A priority patent/AR197624A1/en
Priority to US05/509,807 priority patent/US4044023A/en
Priority to US05/972,845 priority patent/US4242348A/en
Priority to US06/191,100 priority patent/US4317835A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Phenyl- or thienyl-alkylidene amino-oxy-alkanoic acids basic esters - as antiinflammatory agents and analgesics. Cpds. (I), their salts and medicaments contg. them where A is S or -CH=CH-, R1 is halogen, CF3 or Me, R2 is halogen while R1 or R2 may be H, R3 is H or Me, R5 is 1-5C alkylene, m and n are 0 or 1 and m + n is 1 or 2 R5 is 1-6C-alkylene opt. substd. by phenyl, Y is 5 or 6-membered cyclic hydrocarbyl residue or Y-N(R6 or R7) is a mono- or bi-cyclic heterocyclic ring of up to 10 ring atoms and opt. contg. S and opt. substd. by Me, R6 and R7 are H or 1-8C alkyl (and together up to 80C) opt. substd. by OH, 1-4C-alkoxy or a residue (II). and R6 is 3-8C cycloalkyl, phenyl, halophenyl, totyl, 7-9C-phenylalkyl, pyridyl or acyl (up to 10C) or NR6R7 is a mono or bicyclic heterocyclic residue of up to 10 ring atoms and opt. contg. O or a further N atom, are prepd. by methods for forming basic esters or oxime ethers.
NL7102715A 1970-06-11 1971-03-02 Phenyl-or thienyl-alkylidene amino-oxy-alkanoic acid basic esters - - as anti-inflammatory agents and analgesics NL7102715A (en)

Priority Applications (29)

Application Number Priority Date Filing Date Title
AR236029A AR205682A1 (en) 1970-06-11 1971-01-01 METHOD OF PRODUCTION OF AMINO-OXYACETIC (4-CHLORO-ALPHA-METHYLBENZYLIDEN) ESTER (2-DIMETHYLAMINOETHYL) ACID AND ITS ACID ADDITION SALTS FORMED WITH PHARMACOLOGICALLY ACCEPTABLE ACIDS
NL7102715A NL7102715A (en) 1971-03-02 1971-03-02 Phenyl-or thienyl-alkylidene amino-oxy-alkanoic acid basic esters - - as anti-inflammatory agents and analgesics
CH680774A CH568968A5 (en) 1970-06-11 1971-06-08
DK278271AA DK129513B (en) 1970-06-11 1971-06-08 Analogous process for the preparation of basic substituted alkylideneaminooxyalkylcarboxylic acid esters or acid addition salts thereof.
GB1941671*[A GB1325231A (en) 1970-06-11 1971-06-08 Basic substituted alkylidenamino-oxyalkyl-carboxylic-acid esters
CH680874A CH571481A5 (en) 1970-06-11 1971-06-08
AT1110372A AT313256B (en) 1970-06-11 1971-06-08 Process for the preparation of new basic esters of substituted alkylideneaminooxyalkanecarboxylic acids and their acid addition salts
CH829871A CH561179A5 (en) 1970-06-11 1971-06-08
CH680974A CH571482A5 (en) 1970-06-11 1971-06-08
AT1110472A AT313875B (en) 1970-06-11 1971-06-08 Process for the preparation of new basic esters of substituted alkylidene-amino-oxyalkanecarboxylic acids and their acid addition salts
CA115,079A CA947763A (en) 1970-06-11 1971-06-08 Basic substituted-alkylidenamino-oxylalkyl-carboxylic-acid esters
SE7107416A SE401177B (en) 1970-06-11 1971-06-08 METHOD OF PREPARING NEW BASIC SUBSTITUTED ALKYLIDENAMINO-OXIALCYLCARBOXYLIC ACID ESTERS
DE2128375A DE2128375C3 (en) 1970-06-11 1971-06-08 Basic substituted alkylideneamino-oxyalkyl-carboxylic acid esters, their acid addition salts, processes for their production and pharmaceutical preparations containing them
AT494571A AT313254B (en) 1970-06-11 1971-06-08 Process for the preparation of new basic esters of substituted alkylideneaminooxyalkanecarboxylic acids and their acid addition salts
MX002414U MX3034E (en) 1970-06-11 1971-06-08 PROCEDURE FOR PREPARING ACID ESTERS OF ALKYL IDEN AMINO OXI ALKYL CARBOXYL
AT1110172A AT313255B (en) 1970-06-11 1971-06-08 Process for the preparation of new basic esters of substituted alkylideneaminooxyalkanecarboxylic acids and their acid addition salts
MX002463U MX3077E (en) 1970-06-11 1971-06-08 PROCEDURE TO PREPARE BENCIL IDEN AMINO - OXI ALKYL - CARBOXYL ACID ESTERS
IL37013A IL37013A (en) 1970-06-11 1971-06-09 Basically substituted alkylidene-aminooxyalkyl-carboxylic acid esters,their preparation and pharmaceutical compositions containing them
BE768321A BE768321A (en) 1970-06-11 1971-06-09 NEW BASIC ESTERS OF ALKYLIDENE ACID (SUBSTITUTE) - AMINO-OXYALKYLCARBOXYLIC
ES392072A ES392072A1 (en) 1970-06-11 1971-06-09 Novel basic substituted-alkylidenamino-oxy alkyl-carboxylic-acid esters
JP4026971A JPS549186B1 (en) 1970-06-11 1971-06-09
US00151793A US3853955A (en) 1970-06-11 1971-06-10 Novel basic substituted-alkylidenamino-oxy alkyl-carboxylic-acid esters
FR7121298A FR2100751B1 (en) 1970-06-11 1971-06-11
AR249269A AR197517A1 (en) 1970-06-11 1973-07-25 PRODUCTION METHOD OF ESTER (2) DIMETHYLAMINOETHYL) ACID (4-CHLORO-ALPHA-METHYLBENZYLIDEN) AMINO OXYACETIC AND ITS ACID ADDITION SALTS FORMED WITH PHARMACOLOGICALLY ACCEPTABLE ACIDS
AR249271A AR197624A1 (en) 1970-06-11 1973-07-25 PRODUCTION METHOD OF ESTER (2-DIMETHYLAMINOETHYL) FROM AMINO-OXYACETIC (4-CHLORO-ALPHA-METHYLBENZYLIDEN) ACID
AR249270A AR197623A1 (en) 1970-06-11 1973-07-25 PRODUCTION METHOD OF ESTER (2-DIMETHYLAMINOETHYL) FROM AMINO-OXYACETIC (4-CHLORO-ALPHA-METHYLBENZYLIDEN) ACID
US05/509,807 US4044023A (en) 1970-06-11 1974-09-27 Novel basic substituted-alkylidenamino-oxylalkylcarboxylic-acid esters
US05/972,845 US4242348A (en) 1970-06-11 1978-12-26 Novel basic substituted-alkylidenamino-oxylalkyl-carboxylic-acid esters
US06/191,100 US4317835A (en) 1970-06-11 1980-09-26 Novel basic substituted-alkylidenamino-oxyalkyl-carboxylic acid esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7102715A NL7102715A (en) 1971-03-02 1971-03-02 Phenyl-or thienyl-alkylidene amino-oxy-alkanoic acid basic esters - - as anti-inflammatory agents and analgesics

Publications (1)

Publication Number Publication Date
NL7102715A true NL7102715A (en) 1972-09-05

Family

ID=19812591

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7102715A NL7102715A (en) 1970-06-11 1971-03-02 Phenyl-or thienyl-alkylidene amino-oxy-alkanoic acid basic esters - - as anti-inflammatory agents and analgesics

Country Status (1)

Country Link
NL (1) NL7102715A (en)

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