NL7001865A - Alpha 1-acyl-2-methylindolyl-3 carboxylic acid derivs - Google Patents

Alpha 1-acyl-2-methylindolyl-3 carboxylic acid derivs

Info

Publication number
NL7001865A
NL7001865A NL7001865A NL7001865A NL7001865A NL 7001865 A NL7001865 A NL 7001865A NL 7001865 A NL7001865 A NL 7001865A NL 7001865 A NL7001865 A NL 7001865A NL 7001865 A NL7001865 A NL 7001865A
Authority
NL
Netherlands
Prior art keywords
alkyl
methylindolyl
alkenyl
alpha
acyl
Prior art date
Application number
NL7001865A
Other versions
NL154731B (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL6609940A external-priority patent/NL6609940A/xx
Application filed filed Critical
Priority to NL707001865A priority Critical patent/NL154731B/en
Publication of NL7001865A publication Critical patent/NL7001865A/en
Publication of NL154731B publication Critical patent/NL154731B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Aliphatic alpha-(1-acylated 2-methylindolyl-(3)) carboxylic acids (I) R2=H or (9C) hydrocarbon, such as alkyl, alkenyl, cycloalkyl, aryl or aralkyl; R3=H, alkyl or alkenyl; R4=H, halogen, alkyl, or alkenyl; R5=H, halogen, alkyl, alkoxy, nitro, cyano, halogenoalkyl, hydroxyl, mercapto, benzylmercapto, substituted benzylmercapto, opt. substd. benzyloxy, dialkylsulphonamido, cycloalkyl or cycloalkylalkoxy; A=opt. substd. aroyl or heteroaroyl with less than 3 condensed rings. Anti-inflammatory activity and effective in the prevention and inhibition of granuloma-tissue formation. May also be used in the treatment of arthritis and dermatological, etc. diseases which react to treatment with anti-inflammatory agents.
NL707001865A 1965-07-14 1970-02-10 PROCESS OF PREPARING AN ALPHA (1-ACYLATED INDOLYL- (3)) ALIPHATIC CARBONIC ACID OR ANY SUBSTITUTED DERIVATIVE THEREOF FROM ANY 1-6 CARBON ATOMS CONTAINING 1-6 CARBON ATOMS IN THE ALKYL GROUP OF CARBOARD OR SECONDARY ALIPHATIC CARBONIC ACID. NL154731B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL707001865A NL154731B (en) 1965-07-14 1970-02-10 PROCESS OF PREPARING AN ALPHA (1-ACYLATED INDOLYL- (3)) ALIPHATIC CARBONIC ACID OR ANY SUBSTITUTED DERIVATIVE THEREOF FROM ANY 1-6 CARBON ATOMS CONTAINING 1-6 CARBON ATOMS IN THE ALKYL GROUP OF CARBOARD OR SECONDARY ALIPHATIC CARBONIC ACID.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47204165A 1965-07-14 1965-07-14
NL6609940A NL6609940A (en) 1965-07-14 1966-07-14
NL707001865A NL154731B (en) 1965-07-14 1970-02-10 PROCESS OF PREPARING AN ALPHA (1-ACYLATED INDOLYL- (3)) ALIPHATIC CARBONIC ACID OR ANY SUBSTITUTED DERIVATIVE THEREOF FROM ANY 1-6 CARBON ATOMS CONTAINING 1-6 CARBON ATOMS IN THE ALKYL GROUP OF CARBOARD OR SECONDARY ALIPHATIC CARBONIC ACID.

Publications (2)

Publication Number Publication Date
NL7001865A true NL7001865A (en) 1970-04-22
NL154731B NL154731B (en) 1977-10-17

Family

ID=26644065

Family Applications (2)

Application Number Title Priority Date Filing Date
NL707001866A NL154732B (en) 1965-07-14 1970-02-10 PROCESS FOR PREPARING AN ALPHA (1-ACYLATED INDOLYL- (3)) ALIPHATIC CARBONIC ACID OR A SUBSTITUATED DERIVATIVE FROM A TERT. ALKYL ESTER OF THAT CARBONIC ACID.
NL707001865A NL154731B (en) 1965-07-14 1970-02-10 PROCESS OF PREPARING AN ALPHA (1-ACYLATED INDOLYL- (3)) ALIPHATIC CARBONIC ACID OR ANY SUBSTITUTED DERIVATIVE THEREOF FROM ANY 1-6 CARBON ATOMS CONTAINING 1-6 CARBON ATOMS IN THE ALKYL GROUP OF CARBOARD OR SECONDARY ALIPHATIC CARBONIC ACID.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NL707001866A NL154732B (en) 1965-07-14 1970-02-10 PROCESS FOR PREPARING AN ALPHA (1-ACYLATED INDOLYL- (3)) ALIPHATIC CARBONIC ACID OR A SUBSTITUATED DERIVATIVE FROM A TERT. ALKYL ESTER OF THAT CARBONIC ACID.

Country Status (1)

Country Link
NL (2) NL154732B (en)

Also Published As

Publication number Publication date
NL154731B (en) 1977-10-17
NL154732B (en) 1977-10-17
NL7001866A (en) 1970-04-22

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Legal Events

Date Code Title Description
V1 Lapsed because of non-payment of the annual fee
NL80 Abbreviated name of patent owner mentioned of already nullified patent

Owner name: MERCK