NL6502977A - - Google Patents

Info

Publication number
NL6502977A
NL6502977A NL6502977A NL6502977A NL6502977A NL 6502977 A NL6502977 A NL 6502977A NL 6502977 A NL6502977 A NL 6502977A NL 6502977 A NL6502977 A NL 6502977A NL 6502977 A NL6502977 A NL 6502977A
Authority
NL
Netherlands
Application number
NL6502977A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NL6502977A publication Critical patent/NL6502977A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
NL6502977A 1964-03-09 1965-03-09 NL6502977A (US06521211-20030218-C00004.png)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US350519A US3392173A (en) 1964-03-09 1964-03-09 Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation

Publications (1)

Publication Number Publication Date
NL6502977A true NL6502977A (US06521211-20030218-C00004.png) 1965-09-10

Family

ID=23377073

Family Applications (1)

Application Number Title Priority Date Filing Date
NL6502977A NL6502977A (US06521211-20030218-C00004.png) 1964-03-09 1965-03-09

Country Status (9)

Country Link
US (1) US3392173A (US06521211-20030218-C00004.png)
BE (1) BE660843A (US06521211-20030218-C00004.png)
CH (1) CH507970A (US06521211-20030218-C00004.png)
DE (3) DE1795823C3 (US06521211-20030218-C00004.png)
ES (1) ES310240A1 (US06521211-20030218-C00004.png)
FR (2) FR1449628A (US06521211-20030218-C00004.png)
GB (1) GB1095833A (US06521211-20030218-C00004.png)
NL (1) NL6502977A (US06521211-20030218-C00004.png)
SE (1) SE330700B (US06521211-20030218-C00004.png)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
HU165986B (US06521211-20030218-C00004.png) * 1973-02-16 1974-12-28
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4209443A (en) * 1976-02-13 1980-06-24 Richter Gedeon Vegyeszeti Gyar Rt. Process for separating pharmaceutically active diindole alkaloids
US4143041A (en) * 1977-01-19 1979-03-06 Eli Lilly And Company 4'-Deoxyvincristine and related compounds
HU178084B (en) * 1977-05-31 1982-03-28 Richter Gedeon Vegyeszet New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue
US4195022A (en) * 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
FR2461714A1 (fr) 1979-07-17 1981-02-06 Anvar Nouvelle classe de composes bis-indoliques utiles comme medicaments et procede pour leur preparation
EP0123441B1 (en) * 1983-03-30 1990-10-03 Lilly Industries Limited Vincaleukoblastine derivatives
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
HU193318B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing new bis- indol derivatives
HU198074B (en) * 1985-06-12 1989-07-28 Richter Gedeon Vegyeszet Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
JP4814520B2 (ja) * 2002-05-15 2011-11-16 エンドサイト,インコーポレイテッド ビタミン−マイトマイシン結合体
NZ541846A (en) 2003-01-27 2008-12-24 Endocyte Inc Vitamin receptor binding drug delivery conjugates
US8288557B2 (en) * 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US8044200B2 (en) * 2005-03-16 2011-10-25 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
WO2007022493A2 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs, and derivatives
CN103893778A (zh) 2005-08-19 2014-07-02 恩多塞特公司 多药物配体缀合物
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2489372A3 (en) * 2007-03-14 2013-01-02 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
CN104383553A (zh) * 2007-06-25 2015-03-04 恩多塞特公司 含有亲水性间隔区接头的共轭物
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
WO2009055562A1 (en) * 2007-10-25 2009-04-30 Endocyte, Inc. Tubulysins and processes for preparing
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
JP2015536323A (ja) 2012-10-16 2015-12-21 エンドサイト・インコーポレイテッドEndocyte, Inc. 非天然アミノ酸を含む薬物送達結合体および使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3169968A (en) * 1962-05-08 1965-02-16 Ciba Geigy Corp Esters of ajmaline and related compounds
US3225053A (en) * 1963-01-10 1965-12-21 Lilly Co Eli Quebrachidine and derivatives

Also Published As

Publication number Publication date
DE1795823C3 (de) 1982-04-15
DE1545760C3 (de) 1978-10-05
DE1795823B2 (de) 1981-04-30
DE1795763A1 (de) 1974-11-21
GB1095833A (en) 1967-12-20
DE1795763C3 (de) 1978-06-29
CH507970A (de) 1971-05-31
FR6668M (US06521211-20030218-C00004.png) 1969-02-03
DE1795763B2 (de) 1977-11-10
DE1545760A1 (de) 1969-11-27
DE1795823A1 (de) 1976-02-05
US3392173A (en) 1968-07-09
SE330700B (US06521211-20030218-C00004.png) 1970-11-30
BE660843A (US06521211-20030218-C00004.png) 1965-09-09
ES310240A1 (es) 1965-10-16
FR1449628A (fr) 1966-08-19
DE1545760B2 (de) 1978-02-09

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