NL2022316B1 - Ionisation chamber, assembly comprising such chamber and method for measuring radioactivity of radioactive pharmaceutical - Google Patents

Ionisation chamber, assembly comprising such chamber and method for measuring radioactivity of radioactive pharmaceutical Download PDF

Info

Publication number
NL2022316B1
NL2022316B1 NL2022316A NL2022316A NL2022316B1 NL 2022316 B1 NL2022316 B1 NL 2022316B1 NL 2022316 A NL2022316 A NL 2022316A NL 2022316 A NL2022316 A NL 2022316A NL 2022316 B1 NL2022316 B1 NL 2022316B1
Authority
NL
Netherlands
Prior art keywords
chamber
wall
sections
connection
ionization chamber
Prior art date
Application number
NL2022316A
Other languages
Dutch (nl)
Inventor
Johan Wijmans Frans
Original Assignee
Comecer Netherlands B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Comecer Netherlands B V filed Critical Comecer Netherlands B V
Priority to NL2022316A priority Critical patent/NL2022316B1/en
Application granted granted Critical
Publication of NL2022316B1 publication Critical patent/NL2022316B1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16—Measuring radiation intensity
    • G01T1/185—Measuring radiation intensity with ionisation chamber arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T7/00—Details of radiation-measuring instruments
    • G01T7/02—Collecting means for receiving or storing samples to be investigated and possibly directly transporting the samples to the measuring arrangement; particularly for investigating radioactive fluids
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J47/00—Tubes for determining the presence, intensity, density or energy of radiation or particles
    • H01J47/02—Ionisation chambers

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Ionisation chamber configured for measuring radioactive pharmaceuticals, the ionisation chamber comprising: — an inner wall and an outer wall that are connected to each other at opposite ends, wherein 5 the inner wall and the outer wall form a gas space that is fillable with an ionisable gas; — electrodes that are positioned at least partially in to the gas space, wherein the electrodes are connectable to a measuring unit and/or measuring equipment; and — a sample space that is surrounded by the inner wall, wherein a sample to be measured, for example a sterile seringe, is insertable into the sample space; 10 wherein the ionisation chamber comprises at least two chamber sections that are disconnectably connected to each other, wherein the ionisation chamber has a closed state and an open state, wherein, in the open state of the ionisation chamber, the at least two chamber sections are disconnected from each other.

Description

IONISATION CHAMBER, ASSEMBLY COMPRISING SUCH CHAMBER AND METHOD
FOR MEASURING RADIOACTIVITY OF RADIOACTIVE PHARMACEUTICAL The present invention relates to an ionisation chamber, an assembly comprising such an ionisation chamber and a method for measuring radioactivity of a pharmaceutical with the use of such an ionisation chamber.
Injection systems and syringe dispensing systems in which radioactive pharmaceuticals are used, are known from practice for several years. Such systems consists of a hardware part and a disposable kit. The hardware part controls the procedure and comprises an ionisation chamber in which part of the disposable kit, such a syringe, is mountable. The disposable kit comprises a sterile container, a sterile syringe and a hollow tube connecting the container and the syringe to each other. The disposable kit is manufactured to form a single sterile unit in which a radioactive pharmaceutical is held.
In order to establish the radioactivity of the pharmaceutical, the syringe is mounted in the {5 ionisation chamber. The ionisation chamber is a cylindrical passthrough ionisation chamber that is connectable to a read-out unit. The ionisation chamber consist of two hollow, concentrically placed cylinders that are connected to each other at opposite ends to form an enclosed space between the inner and the outer cylinder. The enclosed space is provided with an ionisable gas and connected to the read-out unit. The ionisation chamber further comprises an inner space in which the syringe is mountable for measuring the radioactive pharmaceutical. The inner space is formed such that the syringe snugly fits inside.
A disadvantage of the known ionisation chambers is that mounting the syringe in the inner space of the ionisation chamber requires the syringe to be disconnected from the remainder of the disposable unit, which compromises the sterility of the disposable unit as a whole, because the radioactive pharmaceutical is exposed to open air. This poses a (severe) risk for the patient that will be injected with the radiopharmaceutical.
The invention is aimed at obviating the aforementioned disadvantage.
To that end, the invention provides an ionisation chamber configured for measuring radioactive pharmaceuticals, the ionisation chamber comprising: — an inner wall and an outer wall that are connected to each other at opposite ends, wherein the inner wall and the outer wall form a gas space that is fillable with an ionisable gas; — electrodes that are at least partially positioned in to the gas space, wherein the electrodes are connectable to measuring equipment; and — a sample space that is surrounded by the inner wall, wherein a sample to be measured, for example a sterile seringe, is insertable into the sample space,
wherein the ionisation chamber comprises at least two chamber sections that are disconnectably connected to each other, wherein the ionisation chamber has a closed state and an open state, wherein, in the open state of the ionisation chamber, the at least two chamber sections are disconnected from each other.
It will be understood that radioactive pharmaceuticals can be radioactive pharmaceuticals for treating various diseases such as thyroid cancer, hyperthyroidism, metastatic cancer, or cancer in general and the like. Furthermore, it can also relate to a tracer, for example for positron emission tomography scan or computer tomography. Examples of such tracers are "F-FDG, '*F-FMISO, SEFLT, iodine based tracers, and the like. Thus radioactive pharmaceuticals can also be referred to as medicine, tracer, medicament, pharmaceutic, cure, and the like.
Due to the fact that the ionisation chamber according to the invention is provided with two chamber sections that are disconnectable from each other, the part of the disposable kit that contains or will contain the radioactive pharmaceutical, such as for example a syringe, is mountable in the ionisation chamber without the need of decoupling it from the other parts of the disposable kit. This provides the advantage that the sterility of the disposable kit is kept intact during mounting and measuring in the ionisation chamber. The risk of contamination is therewith substantially obviated.
Due to the presence of the chamber sections, the ionisation chamber can be in an open state and in a closed state, wherein the chamber sections are connected with each other and the inner wall and the outer wall form a substantially continuous surface. It is preferred that the inner wall in a closed state of the ionisation chamber closely surrounds the radioactive pharmaceutical, and/or the holder holding that material, in the sample space to prevent moving and/or tilting of the radioactive pharmaceutical. In an open state of the ionisation chamber according to the invention, the chamber sections are disconnected from each other. The disconnection may be partially, i.e.
some parts of the chamber sections are still adjacent and/or connected to each other whereas other are not, or may be a complete disconnection in which the two chamber sections are completely separated from each other. In both cases, the chamber sections will be sufficiently spaced apart from each other to mount the radioactive pharmaceutical in the sample space without it has to be disconnected from the other parts of the disposable kit.
It is preferred that the ionisation chamber comprises two chamber sections, although providing more than two chamber sections is also possible. This may for example entail an ionisation chamber comprising three chamber sections, of which a single section is connected to a wall or mount and wherein the remaining sections are disconnectably connected to the wall- mounted section for providing the opening to the inner space.
It is preferred that each of the section chambers is provided with its own gas space, which is not fluidly connected with the environment. It is furthermore preferred that each of the section chambers is provided with its own electrode.
In an embodiment according to the invention, each chamber section may comprise an inner wall section and an outer wall section that are connected to each other at opposite ends, connection walls that extend between the opposite ends and connect the inner wall section and the outer wall section to each other, a sectional gas space that is enclosed by the inner wall section, the outer wall section and the connection wall sections and that is fillable with an ionisable gas, wherein each connection wall is associated with a connection wall of another one of the at least two chamber IO sections.
The chamber sections are preferably formed as building blocks that together form the ionisation chamber. According to this embodiment, each of the chamber sections comprises connection walls that are useable and configured for connecting to connection walls of other chamber sections. It is noted that, in the closed state of the ionisation chamber, each connection wall is contiguous with the associated connection wall of the another one of the at least two chamber sections, preferably such that the inner wall and the outer wall form a substantially continuous surface. In the open state of the ionisation chamber, each connection wall is spaced apart from the associated connection wall of the other one of the at least two chamber sections, therewith forming an opening for inserting a sample into the sample space.
It is preferred that the chamber sections are configured such that, when connected to each other, they form a very close fit, i.e. snugly fit to each other, such that the inner and outer wall of the ionisation chamber form substantially continuous surfaces. This is achieved by the connection walls, which are preferably configured as mating surfaces, which means that the design and construction of the connection walls is chosen to provide such a close fit. This may for example be provided with providing the connection walls as flat surfaces, yet may also be provided by providing the connection walls with profiled surfaces, wherein associated connection walls have associated, mating surface profiles. In another example, the connection walls may be manufactured of, or contain patches of, magnetic or magnetisable material that are configured to be connected to each other to connect the chamber sections to each other.
In an embodiment according to the invention, each chamber section may comprise at least one electrode, wherein the electrodes are configured to be connectable to electrical conduits to form an electrical circuit, and wherein the electrical circuit preferably comprises a measuring unit for measuring one of more of an electric potential difference, a current and/or an electrical resistance.
Positioning an electrode in each of the chamber sections has the advantage that each of the electrodes is useable for performing the measurement of the radioactive pharmaceutical. It ishowever also possible, especially with a larger number of chamber sections, to provide a limited number of section chambers with an electrode.
In an embodiment according to the invention, the connection between the chamber sections may comprise one or more of a hinged connection, a magnetic connection and/or a clicking connection.
By providing a hinged, magnetic and/or clicking connection between the chamber sections a simple, reliable and easily usable connection is provided.
Due to the medical environment in which ionisation chambers are used, it is preferred that the connection between the chambers can be easily operated and additionally is safe and reliable.
This is achieved by providing one of the abovementioned connections.
Moreover, a magnetic and/or clicking connection may provide the additional advantage that no external connections are required on the surface of the ionisation chamber as the connection may be internalised in the chamber walls.
A hinged connection provides the additional advantage that the chamber sections can be disconnected from each other, without completely removing them from each other.
In other words, it provides the possibility of opening the inner space without completely having to disconnect the chamber sections from each other.
This increases safety, reliability and handling, because the various parts of the ionisation chamber will always remain together.
In an embodiment according to the invention, the ionisation chamber may have a substantially cylindrical shape, wherein the inner wall and the outer wall extend substantially concentric to each other around a central axis, and wherein the connection walls extend in a substantially radial outwardly direction from the central axis from the inner wall to the outer wall.
In a preferred embodiment according to the invention, the ionisation chamber comprises a substantially cylindrical shape with the inner and outer wall concentrically extending around a central axis.
The cylindrical shape provides the advantage that the inner wall is by definition forming a cylindrical inner space in which a syringe is mountable.
Furthermore, by providing the inner and outer wall with a cylindrical shape, it is easy to create different chamber sections.
This is easily performed by providing a connection wall between the inner and the outer wall, thus forming chamber sections.
In addition, a cylindrical shape has excellent pressure resistance, which allows the (sectional) sample spaces to be pressurised.
In an embodiment according to the invention, the ionisation chamber may comprise connecting means for disconnectably connecting the at least two chamber sections to each other.
An advantage of providing connection means is that the chamber sections can be easily connected to each other.
It is preferred that the connection means are provided on the outside of the ionisation chamber, such as for example on the outer wall sections of the chamber sections near the connection walls.
The connection means may be chosen from a wide variety of connection means, which are suitable for providing a close, snugly fitting connection between the chamber sections.
In an embodiment according to the invention, the connecting means may comprise one or more of a hinge that connects the chamber sections and/or a hook-and-loop connection and/or a bayonet-connection and/or a magnetic connection.
The connection means according to this embodiment of the invention have the advantage 5 that they are readily available, easy to use during operation and can be incorporated in the design of the ionisation chamber and/or the chamber sections thereof.
A magnetic connection has the advantage that it can be readily incorporated in either the connection walls and/or the outer walls to provide a connection. Furthermore, the magnetic connection has the advantage that it is easy to connect and disconnected, which increases user IO handling and reduces the time that is required to prepare a radioactive pharmaceutical sample for measuring in the ionisation chamber.
The connection means may also be provided as a connection or clamping band that is slidable over the outer wall sections of the chamber sections to clamp the chamber sections together. The clamping band can be slided onto and over an end of the ionisation chamber that is free, for example a non-tubed end of the syringe. The advantage of a clamping band is that it can be easily attached onto and detached from the ionisation chamber. Furthermore, a clamping band provides a relatively cost-effective solution to connect the chamber sections.
It is preferred that the chamber sections are on one side connected to each other using a hinge connection, which advantageously allows the chamber sections to be rotated vis-a-vis each other around an axis formed by the hinge. This provides several advantages over other connection means. First of all, a hinged connection prevents the chamber sections from completely disconnecting from each other and allows an easy opening of the sample space. As a result, user handling is improved. Secondly, it allows the ionisation chamber to be connected to an external structure, such as a wall, while still allowing easy access to the sample space by simply rotating the non-wall mounted chamber section relative to the wall-mounted chamber section. Furthermore, the hinge reduces the time that is required to prepare a radioactive pharmaceutical sample for measuring in the ionisation chamber. A hinged connection is preferably combined with a different connection means to provide the abovementioned advantages.
In an embodiment according to the invention, the connections means may be formed by the connection walls, wherein the connection walls are manufactured from a magnetic and/or magnetisable material to form a magnetic connection between the associated connection walls.
A magnetic connection has the advantage that it can be readily incorporated in the connection walls to provide a connection. Furthermore, the magnetic connection has the advantage that it is easy to connect and disconnect, which increases user handling and reduces the time that is required to prepare a radioactive pharmaceutical sample for measuring in the ionisation chamber. In addition, a magnetic connection has the advantage that it is not visible or reachable per se fromthe outside of the ionisation chamber, which reduces the risk of accidental release of the chamber sections from each other.
The magnetic connection may be provided as a (semi-)permanent connection, yet may also be an actuatable connection that can be switched on and/or off using a switch or remote control.
This increases the safety of the device, since it requires a specific action to release the sample from the ionisation chamber. It may additionally be provided with a warning signal that indicates whether a good hold is achieved.
In an embodiment according to the invention, the at least two chamber sections are two chamber sections.
In a preferred embodiment of the invention, two chamber sections are provided. The advantage of two chamber sections is that it provides a cost-effective and efficient solution to the sterility problem without increasing the handling and processing time. Preferably, the two chamber sections have a similar shape, for example two similarly or identically formed halves of a cylindrical shape. However, non-similar shapes may be used as well.
In an embodiment according to the invention, the ionisation chamber may be manufactured from one or more of a group of: metal, preferably aluminium, plastics, carbon-reinforced plastic, and/or (reinforced) glass.
Although the ionisation chamber may be manufactured from a variety of materials, metals, especially aluminium, is preferred for its suitability for the process. Furthermore, metal and/or alominium may easily be combined with a magnetic and/or hinged connection.
A combination of the materials of which the ionization chamber may be manufactured comprises aluminium and lead. This results in a ionization chamber with the above mentioned effects and advantages. An extra effect of such an ionization chamber is that it shields the radioactive source and reduces the amount of radiation to which the operator is exposed.
In an embodiment according to the invention, the inner and the outer wall may preferably comprise aluminium, and wherein parts of the inner and the outer wall are manufactured from a magnetisable material to cooperate with the connections means.
This embodiment combines the advantage of a light-weight aluminium shell with the easy- of-handling associated with a magnetic coupling.
The invention also relates to an assembly for measuring radioactive pharmaceuticals, the assembly comprising an ionisation chamber according to any one of the preceding clauses and a disposable kit, wherein the disposable kit comprises: — a sterile syringe; — a sterile container for holding a radioactive pharmaceutical;
— a sterile hollow tube connecting an opening of the sterile syringe with an opening of the sterile container for transferring a radioactive pharmaceutical from the syringe to the container or from the container to the syringe. The assembly according to the invention has similar effects and advantages as the abovementioned ionisation chamber according to the invention.
In an embodiment of the assembly according to the invention, the assembly may also comprise mounting means for mounting and/or holding the ionisation chamber and/or the disposable Kit.
The assembly according to the invention may advantageously also comprise mounting means for mounting and/or holding one or both of the ionisation chamber and/or the disposable kit.
The advantage of providing mounting means to the assembly is that the assembly or parts thereof may be connected to a location at which the assembly is normally used, such as for example a wall of a measurement or treatment room or space. In an example, such mounting means may comprise glue or Velcro, yet may also comprise a housing to which the ionisation chamber is connectable. It may also comprise a housing, a platform for placing the assembly or a combination thereof, which allows the ionisation chamber to be fixedly connected to the wall, whereas the disposable kit is removably placed at the platform.
In an embodiment of the assembly according to the invention, the assembly may further comprise electric conduits and a measuring unit for measuring an electric potential difference between the electrodes to establish the radioactive activity of the radioactive pharmaceutical.
The electric conduits and the measuring unit may be provided as separate units or may be connected to or at least partially integrated in the ionisation chamber. Furthermore, the mounting means may also be configured for mounting and/or holding the measuring unit and/or the electric cables. This allows the assembly to be mounted to a wall or cupboard for example, such that it is readily useable.
In an embodiment of the assembly according to the invention, the assembly may further comprise a read-out unit that is configured for displaying the electric potential difference between the electrodes and/or radioactive activity.
It is preferred that the assembly also comprises a read-out unit for displaying the results of the measurements. Displaying should in this sense be construed in a broad sense and also includes any form of visual displaying or showing of the results. The read-out unit may be a computing unit, such as a computer, a hand-held device, or any other device comprising a processor for processing and displaying the results of the measurement to a user.
The invention also relates to a method for measuring the radioactivity of a radioactive pharmaceutical, the method comprising the steps of:
— providing an ionisation chamber according to the invention, or an assembly according to the invention; — opening the ionisation chamber by disconnecting the chamber sections; — inserting the pharmaceutical into the inner space; — closing the ionisation chamber by connecting the chamber sections; — measuring the radioactive pharmaceutical; — removing the pharmaceutical from the inner space.
The method according to the invention has similar effects and advantages as the abovementioned ionisation chamber and assembly according to the invention.
The method according to the invention provides a reliable and easy method for measuring the radioactivity of a pharmaceutical, for example in a syringe, without compromising the sterile nature of the radioactive pharmaceutical. As a result, the risk of contamination of the patient due to exposure of the pharmaceutical to non-sterile conditions is obviated.
In an embodiment of the method according to the invention, the step of removing the pharmaceutical from the sample space may comprise opening the ionisation chamber, removing the pharmaceutical from the sample space and closing the ionisation chamber.
Further advantages, features and details of the invention are elucidated on the basis of preferred embodiments thereof, wherein reference is made to the accompanying drawings, in which: — Figure 1a shows a perspective view of an example of an ionisation chamber according to the invention in a closed state; — Figure 1b shows a perspective view of the example of figure 1a in an open state; — Figure 2 shows a cross-sectional view of the example of figure 1 along the line A-A; — Figure 3a shows an example of an assembly according to the invention, in which the ionisation chamber is in a closed state; — Figure 3b shows the example of figure 4a with the ionisation chamber in an open position; — Figure 4a shows a perspective view of a second example of an assembly according to the invention in a closed state; and — Figure 4b shows a perspective view of the example of figure 4a in an open state.
In a first example (see figure la, 1b, 2), ionisation chamber 2 comprises inner wall 4 and outer wall 6, which are mutually connected to each other at the respective outer ends 8a, 8b. Tonisation chamber 2 further comprises two chamber sections 10, 12, each comprising inner wall section 14 and outer wall section 16, which are connected to each other by means of connection walls 18, 20. Therewith, inner wall section 14, outer wall section 16 and connection walls 18, 20 enclose sectional gas space 22 which is filled with ionisable gas 24. Chamber sections 10, 12, morespecifically inner wall sections 14 of chamber sections 10, 12 delineate inner space 26 in which a syringe (not shown) is mountable.
In this example, chamber sections 10, 12 each comprise connecting means 28 in the form of magnetic strips 28 that are provided at connection walls 18, 20 of each respective chamber section 10, 12. Each chamber section 10, 12 also comprises electrode 30 (see figure 2), which is mounted at least partially in to sectional gas space 22 and is connectable to an external measurement unit (not shown), for example by means of a cable (not shown). In an example of assembly 100 according to the invention (see figure 3a, 3b), assembly 100 comprises ionisation chamber 102 comprising two chamber sections 110, 112, each comprising inner wall section 114, outer wall section 116 and connection walls 118, 120. Wall sections 114, 116 and connection walls 118, 120 delineate and enclose sectional gas space 122 which is filled with ionisable gas 124. The connection walls 118, 120 are provided with connection means 128, which are in this example magnetic strips 128. When placed together, (inner) wall sections 114 form inner wall 104 and (outer) wall sections 116 form outer wall 106. In some cases connection walls 118, 120 and/or connection means 128 also form part of inner wall 104 and/or outer wall 106. In this case, connection means 128 form both part of inner wall 104 and part of outer wall 106 (see figures 3a, 3b). Assembly 100 further also comprises sterile disposable kit 150, which includes syringe 152, container 154 and hollow tube 156 that connects syringe 152 and container 154 to each other.
Assembly 100 in this example also comprises read-out unit 158 that is configured to read out the measurements from the ionisation chamber 102. The present invention is by no means limited to the above described preferred embodiments thereof.
The rights sought are defined by the following clauses within the scope of which many modifications can be envisaged.
CLAUSES
1. Ionisation chamber configured for measuring radioactive pharmaceuticals, the ionisation chamber comprising: — an inner wall and an outer wall that are connected to each other at opposite ends, wherein the inner wall and the outer wall form a gas space that is fillable with an ionisable gas; — electrodes that are positioned at least partially in to the gas space, wherein the electrodes are connectable to a measuring unit and/or measuring equipment; and — a sample space that is surrounded by the inner wall, wherein a sample to be measured, for example a sterile seringe, is insertable into the sample space; wherein the ionisation chamber comprises at least two chamber sections that are disconnectably connected to each other, wherein the ionisation chamber has a closed state and an open state, wherein, in the open state of the ionisation chamber, the at least two chamber sections are disconnected from each other.
2. Ionisation chamber according to clause 1, wherein each chamber section comprises: — an inner wall section and an outer wall section that are connected to each other at opposite ends; — connection walls that extend between the opposite ends and connect the inner wall section and the outer wall section to each other; and — a sectional gas space that is enclosed by the inner wall section, the outer wall section and the connection walls and that is fillable with an ionisable gas; wherein each connection wall is associated with a connection wall of another one of the at least two chamber sections.
3. lonisation chamber according to any one of the preceding clauses, wherein each chamber section comprises at least one electrode, wherein the electrodes are configured to be connectable to electrical conduits to form an electrical circuit, and wherein the electrical circuit preferably comprises a measuring unit for measuring one of more of an electric potential difference, a current and/or an electrical resistance.
4. Jonisation chamber according to any one of the preceding clauses, wherein the connection between the chamber sections comprises one or more of a hinged connection, a magnetic connection, a clamping connection and/or a clicking connection.
5. lonisation chamber according to any one of the preceding clauses, wherein the ionisation chamber has a substantially cylindrical shape, wherein the inner wall and the outer wall extend substantially concentric to each other around a central axis, and wherein the connection walls extend in a substantially radial outwardly direction from the central axis from the inner wall to the outer wall.
6. lonisation chamber according to any one of the preceding clauses, wherein the ionisation chamber comprises connecting means for disconnectably connecting the at least two chamber sections to each other.
7. lonisation chamber according to clause 6, wherein the connecting means comprise one or more of: a hinge that connects the chamber sections and/or a hook-and-loop connection and/or a bayonet-connection and/or a magnetic connection.
8. Ionisation chamber according to clause 7, when dependent on clause 2, wherein the connections means are formed by the connection walls, wherein the connection walls are manufactured from a magnetic and/or magnetisable material to form a magnetic connection between the associated connection walls.
9. lonisation chamber according to any one of the preceding clauses, wherein the at least two chamber sections are two chamber sections.
10. lonisation chamber according to any one of the preceding clauses, wherein the ionisation chamber is manufactured from one or more of a group of: metal, preferably alaminium or lead, plastics, carbon-reinforced plastic, and/or (reinforced) glass.
11. Ionisation chamber according to clause 10, wherein the inner and the outer wall preferably comprise aluminium, and wherein parts of the inner and the outer wall are manufactured from a magnetisable material to cooperate with the connections means.
12. Assembly for measuring radioactive pharmaceuticals, the assembly comprising an ionisation chamber according to any one of the preceding clauses and a disposable kit, wherein the disposable kit comprises: — a sterile syringe: — a sterile container for holding a radioactive pharmaceutical; and
— a sterile hollow tube connecting an opening of the sterile syringe with an opening of the sterile container for transferring a radioactive pharmaceutical from the syringe to the container or from the container to the syringe.
13. Assembly according to clause 12, wherein the assembly comprises mounting means for mounting and/or holding the ionisation chamber and/or the disposable kit.
14. Assembly according to any one of the clauses 12 — 13, wherein the assembly further comprises electric conduits and a measuring unit for measuring an electric potential difference i0 between the electrodes to establish the radioactive activity of the radioactive pharmaceutical.
15. Assembly according to any one of the clauses 12 — 14, wherein the assembly further comprises a read-out unit that is configured for displaying the electric potential difference between the electrodes and/or radioactive activity.
16. Method for measuring the radioactivity of a radioactive pharmaceutical, the method comprising the steps of: — providing an ionisation chamber according to any one of the clauses | — 11, or an assembly according to the any one of the clauses 12 — 15; — opening the ionisation chamber by disconnecting the chamber sections; — inserting the pharmaceutical into the sample space; — closing the ionisation chamber by connecting the chamber sections; — measuring the radioactive pharmaceutical; and — removing the pharmaceutical from the sample space.
17. Method according to clause 16, wherein the step of removing the pharmaceutical from the sample space comprises: ~ opening the ionisation chamber; — removing the pharmaceutical from the sample space; and — closing the ionisation chamber.

Claims (17)

CONCLUSIESCONCLUSIONS 1. Ionisatiekamer ingericht voor het meten van radioactieve geneesmiddelen en/of farmaceutica, waarbij de ionisatiekamer omvat: — een binnenwand en een buitenwand die met elkaar verbonden zijn nabij uiteinden daarvan, waarbij de binnenwand en de buitenwand een gasruimte vormen die vulbaar is met een ioniseerbaar gas; — elektroden die ten minste ten dele gepositioneerd zijn in de gasruimte, waarbij de elektroden verbindbaar zijn met meetapparatuur; en — een monsterruimte die is omgeven door de binnenwand, waarbij een te meten monster, bijvoorbeeld een steriele spuit, inbrengbaar is in de monsterruimte; waarbij de ionisatiekamer ten minste twee kamersecties omvat die losmakend met elkaar verbonden zijn, waarbij de ionisatiekamer een gesloten toestand en een open toestand heeft, waarbij, in de open toestand van de ionisatiekamer, de ten minste twee kamersecties losgemaakt zijn van elkaar.Ionization chamber adapted to measure radiopharmaceuticals and / or pharmaceuticals, wherein the ionization chamber comprises: - an inner wall and an outer wall which are connected to each other near ends thereof, wherein the inner wall and the outer wall form a gas space which can be filled with an ionizable gas; - electrodes which are at least partially positioned in the gas space, the electrodes being connectable to measuring equipment; and - a sample space which is surrounded by the inner wall, wherein a sample to be measured, for example a sterile syringe, is insertable into the sample space; wherein the ionization chamber comprises at least two chamber sections detachably connected to each other, the ionization chamber having a closed state and an open state, wherein, in the open state of the ionization chamber, the at least two chamber sections are detached from each other. 2. Ionisatiekamer volgens conclusie 1, waarbij iedere kamersectie omvat: - een binnenwandsectie en een buitenwandsectie die met elkaar verbonden zijn aan tegenoverliggende einden; - verbindingswanden die zich uitstrekken tussen de tegenoverliggende einden en de binnenwandsectie en de buitenwandsectie met elkaar verbinden; - een gasruimtesectie die omsloten is door de binnenwandsectie, de buitenwandsectie en de verbindingswandsecties en dat te vullen is met een te ioniseren gas: en waarbij iedere verbindingswand is geassocieerd met een verbindingswand van een andere van de één van de ten minste twee kamersecties.Ionization chamber according to claim 1, wherein each chamber section comprises: - an inner wall section and an outer wall section connected to each other at opposite ends; connecting walls extending between the opposite ends and connecting the inner wall section and the outer wall section together; - a gas space section enclosed by the inner wall section, the outer wall section and the connecting wall sections and which can be filled with a gas to be ionized: and wherein each connecting wall is associated with a connecting wall of another of the one of the at least two chamber sections. 3. lonisatickamer volgens één der voorgaande conclusies, waarbij iedere kamersectie ten minste één elektrode omvat, waarbij de elektroden zijn ingericht om verbonden te zijn met elektrische leidingen om een elektrisch circuit te vormen, en waarbij het elektrische circuit bij voorkeur een meeteenheid voor het meten van één of meer van een elektrische potentiaal, een stroom en/of een elektrische weerstand omvat.The lonization chamber of any one of the preceding claims, wherein each chamber section comprises at least one electrode, the electrodes being arranged to be connected to electrical leads to form an electrical circuit, and wherein the electrical circuit is preferably a measurement unit for measuring includes one or more of an electrical potential, a current and / or an electrical resistance. 4. Ionisatiekamer volgens één der voorgaande conclusies, waarbij de verbinding tussen de kamersecties één of meer van een scharnierverbinding, een magnetische verbinding, een klemverbinding en/of een klikverbinding omvat.Ionization chamber according to any one of the preceding claims, wherein the connection between the chamber sections comprises one or more of a hinge connection, a magnetic connection, a clamp connection and / or a snap connection. 5. Tonisatiekamer volgens één der voorgaande conclusies, waarbij de ionisatiekamer een in hoofdzaak cilindrische vorm heeft, waarbij de binnenwand en de buiten wand zich in hoofdzaak concentrisch naar elkaar rond een centrale as uitstrekken, en waarbij de verbindingswanden zich in een in hoofdzaak radiale naar buiten gerichte van de centrale as van de binnenwand naar de buitenwand uitstrekt.The tonization chamber of any one of the preceding claims, wherein the ionization chamber has a substantially cylindrical shape, the inner wall and outer wall extending substantially concentrically to each other about a central axis, and the connecting walls extending in a substantially radial outward direction. extends from the central axis of the inner wall to the outer wall. 6. Tonisatiekamer volgens één der voorgaande conclusies, waarbij de ionisatiekamer verbindingsmiddelen voor losmakende verbinden de ten minste twee kamersecties met elkaar omvat.A tonization chamber according to any one of the preceding claims, wherein the ionization chamber comprises detachment means for connecting the at least two chamber sections to each other. 7. lonisatickamer volgens conclusie 6, waarbij de verbindingsmiddelen één of meer omvatten van: een scharnier die de kamersecties verbindt en/of een haak-en-lus verbinding en/of een bajonet verbinding en/of een magnetische verbinding.The lonization chamber of claim 6, wherein the connecting means comprises one or more of: a hinge connecting the chamber sections and / or a hook-and-loop connection and / or a bayonet connection and / or a magnetic connection. 8. lonisatiekamer volgens conclusie 7, als afhankelijk van conclusie 2, waarbij de verbindingsmiddelen gevormd zijn door verbindingswanden, waarbij de verbindingswanden vervaardigd zijn uit een magnetisch en/of magnetiseerbaar materiaal om een magnetische verbinding tussen de geassocieerde verbindingswanden te vormen.The ionization chamber of claim 7, as dependent on claim 2, wherein the connecting means are formed by connecting walls, the connecting walls being made of a magnetic and / or magnetizable material to form a magnetic connection between the associated connecting walls. 9, lonisatiekamer volgens één der voorgaande conclusies, waarbij de ten minste twee kamersecties twee kamersecties zijn.9. The lonization chamber of any one of the preceding claims, wherein the at least two chamber sections are two chamber sections. 10. lonisatiekamer volgens één der voorgaande conclusies, waarbij de ionisatiekamer is vervaardigd uit één of meer van een groep van: metaal, bij voorkeur aluminium of lood, plastics, koolstof-verstevigd plastic, en/of (verstevigd) glas.10. Ionization chamber according to any one of the preceding claims, wherein the ionization chamber is made of one or more of a group of: metal, preferably aluminum or lead, plastics, carbon-reinforced plastic, and / or (reinforced) glass. 11. Ionisatiekamer volgens conclusie 10, waarbij de binnen- en de buitenwand bij voorkeur aluminium omvatten, en waarbij delen van de binnen- en de buitenwand vervaardigd zijn uit een magnetiseerbaar materiaal om samen te werken met de verbindingsmiddelen.Ionization chamber according to claim 10, wherein the inner and outer walls preferably comprise aluminum, and wherein parts of the inner and outer walls are made of a magnetizable material to cooperate with the connecting means. 12. Samenstel voor het meten van radioactieve geneesmiddelen, het samenstel omvattende een kamer volgens één der voorgaande conclusies en een verwijderingskit, waarbij de verwijderingskit omvat: - een steriele spuit; - een steriele container voor het houden van een radioactief geneesmiddel; en - een steriele holle buis die een opening van de steriele spuit met een opening van de steriele container verbindt voor het verplaatsen van een radioactief geneesmiddel van de spuit naar de container of van de container naar de spuit.An assembly for measuring radiopharmaceuticals, the assembly comprising a chamber according to any one of the preceding claims and a disposal kit, wherein the disposal kit comprises: - a sterile syringe; - a sterile container for holding a radioactive medicine; and - a sterile hollow tube connecting an opening of the sterile syringe to an opening of the sterile container for transferring a radioactive drug from the syringe to the container or from the container to the syringe. 13. Samenstel volgens conclusie 12, waarbij het samenstel montagemiddelen voor het monteren en/of houden van de ionisatiekamer en/of verwijderingskit omvat.Assembly according to claim 12, wherein the assembly comprises mounting means for mounting and / or holding the ionization chamber and / or removal kit. 14. Samenstel volgens één der conclusies 12 — 13, waarbij het samenstel verder elektrische leidingen en een meeteenheid voor het meten van een elektrisch potentiaal verschil tussen de elektrodes om radioactiviteit van het radioactieve geneesmiddel te bepalen omvat.The assembly of any of claims 12-13, wherein the assembly further comprises electrical leads and a measuring unit for measuring an electrical potential difference between the electrodes to determine radioactivity of the radiopharmaceutical. 15. Samenstel volgens één der conclusies 12 — 14, waarbij het samenstel verder een uitleeseenheid omvat die is ingericht voor het weergeven van het elektrische potentiaal verschil tussen de elektroden en/of radioactiviteit.Assembly according to any one of claims 12-14, wherein the assembly further comprises a read-out unit which is adapted to display the electrical potential difference between the electrodes and / or radioactivity. 16. Werkwijze voor het meten van de radioactiviteit van radioactieve geneesmiddelen, de werkwijze omvattende de stappen van: - het voorzien van een ionisatiekamer volgens één der conclusies 1 — 11, of een samenstel volgens één der conclusies 12 — 15; - het openen van de ionisatiekamer door het losmaken van de kamersecties; - het inbrengen van het geneesmiddel in de monsterruimte; - het sluiten van de ionisatiekamer door het verbinden van de kamersecties; - het meten van het radioactieve geneesmiddel; en - het verwijderen van het geneesmiddel uit de monsterraimte.A method for measuring the radioactivity of radiopharmaceuticals, the method comprising the steps of: - providing an ionization chamber according to any one of claims 1 - 11, or an assembly according to any one of claims 12 - 15; - opening the ionization chamber by detaching the chamber sections; - introducing the medicine into the sample space; - closing the ionization chamber by connecting the chamber sections; - measuring the radioactive medicine; and - removing the drug from the sample well. 17. Werkwijze volgens conclusie 16, waarbij de stap van het verwijderen van het geneesmiddel uit de monsterruimte omvat: - het openen van de ionisatiekamer; - het verwijderen van het geneesmiddel uit de monsterruimte; en - het sluiten van de ionisatiekamer.The method of claim 16, wherein the step of removing the drug from the sample space comprises: - opening the ionization chamber; - removing the drug from the sample space; and - closing the ionization chamber.
NL2022316A 2018-12-27 2018-12-27 Ionisation chamber, assembly comprising such chamber and method for measuring radioactivity of radioactive pharmaceutical NL2022316B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL2022316A NL2022316B1 (en) 2018-12-27 2018-12-27 Ionisation chamber, assembly comprising such chamber and method for measuring radioactivity of radioactive pharmaceutical

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL2022316A NL2022316B1 (en) 2018-12-27 2018-12-27 Ionisation chamber, assembly comprising such chamber and method for measuring radioactivity of radioactive pharmaceutical

Publications (1)

Publication Number Publication Date
NL2022316B1 true NL2022316B1 (en) 2020-07-23

Family

ID=65576602

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2022316A NL2022316B1 (en) 2018-12-27 2018-12-27 Ionisation chamber, assembly comprising such chamber and method for measuring radioactivity of radioactive pharmaceutical

Country Status (1)

Country Link
NL (1) NL2022316B1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066896A (en) * 1975-06-19 1978-01-03 Siemens Aktiengesellschaft Ionographic chamber
WO2007142575A1 (en) * 2006-06-07 2007-12-13 Wickman Goeran Device for measuring absorbed dose in an ionizing radiation field and use of the device
US20090078865A1 (en) * 2004-09-30 2009-03-26 Charles Stark Draper Laboratory, Inc. Apparatus and systems for processing samples for analysis via ion mobility spectrometry

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4066896A (en) * 1975-06-19 1978-01-03 Siemens Aktiengesellschaft Ionographic chamber
US20090078865A1 (en) * 2004-09-30 2009-03-26 Charles Stark Draper Laboratory, Inc. Apparatus and systems for processing samples for analysis via ion mobility spectrometry
WO2007142575A1 (en) * 2006-06-07 2007-12-13 Wickman Goeran Device for measuring absorbed dose in an ionizing radiation field and use of the device

Similar Documents

Publication Publication Date Title
JP6940641B2 (en) Syringe adapter with rotating connector
CA2877932C (en) Radiation shield adapters
JP4847013B2 (en) Method for providing a portable manufacturing facility for radioactive materials
KR20050070030A (en) Pharmaceutical pig and method of use
ES2436740T3 (en) Container injector for immediate load radioactive products
US8563907B2 (en) Radiopharmaceutical heater
NL2022316B1 (en) Ionisation chamber, assembly comprising such chamber and method for measuring radioactivity of radioactive pharmaceutical
CN101516420A (en) Medical unit for the collection, calibration, dilution and/or injection of an injectable radioactive product
BRPI0912144B1 (en) SHIELD ASSEMBLY FOR SYSTEM THAT GENERATES AND INFUNDES RADIOPHARMACEUTICAL PRODUCTS
CN107405596B (en) Additional radiosynthesizer apparatus
ES2401751T3 (en) Sterile single-use device for the preparation of a radiopharmaceutical drug, system and procedure that put this device into operation
Cremonesi et al. Radiation protection in radionuclide therapies with 90 Y-conjugates: risks and safety
US10933200B2 (en) Thermal conditioning device for an injection system
Savisto et al. Automated production of [18F] FTHA according to GMP
US20190341162A1 (en) Device for preparing radioactive solutions
JP6654647B2 (en) Apparatus for synthesizing radiotracer, equipment including the apparatus, and method for obtaining radiotracer using the apparatus
US20080300479A1 (en) Containment tubes and imaging systems employing same
US4474518A (en) Shielded cells having manipulators comprising a master arm and a slave arm
JP6967454B2 (en) Equipment for the manufacture of radiopharmaceuticals with perforation devices
Chaly et al. A large scale manual production of [18F] FDG using a synthetic unit made of sterile disposable components and operated by a master slave manipulator
JP4663995B2 (en) Radiopharmaceutical synthesis administration device
CN216798399U (en) Protective sleeve of injector
Quincoces et al. Design and performance evaluation of single-use whole-sterile “plug & play” kits for routine automated production of [11C] choline and [11C] methionine with radiopharmaceutical quality
CN214691030U (en) Pharmacy department is with device of getting it filled
US20100035350A1 (en) Device and method for labeling and measuring the radiochemical purity of radio-drugs