NL2022314B1 - Needle structure comprising a hollow cannula and a stylet - Google Patents

Needle structure comprising a hollow cannula and a stylet Download PDF

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Publication number
NL2022314B1
NL2022314B1 NL2022314A NL2022314A NL2022314B1 NL 2022314 B1 NL2022314 B1 NL 2022314B1 NL 2022314 A NL2022314 A NL 2022314A NL 2022314 A NL2022314 A NL 2022314A NL 2022314 B1 NL2022314 B1 NL 2022314B1
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Netherlands
Prior art keywords
stylet
needle structure
cannula
needle
parts
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Application number
NL2022314A
Other languages
Dutch (nl)
Inventor
Jean-Pierre Van De Berg Nick
Johannes Van Den Dobbelsteen Johnny
Original Assignee
Univ Delft Tech
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Publication date
Application filed by Univ Delft Tech filed Critical Univ Delft Tech
Priority to NL2022314A priority Critical patent/NL2022314B1/en
Priority to PCT/NL2019/050846 priority patent/WO2020139083A1/en
Application granted granted Critical
Publication of NL2022314B1 publication Critical patent/NL2022314B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3478—Endoscopic needles, e.g. for infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/04—Endoscopic instruments
    • A61B2010/045—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/003—Steerable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/003—Steerable
    • A61B2017/00305—Constructional details of the flexible means
    • A61B2017/00309—Cut-outs or slits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/003—Steerable
    • A61B2017/00318—Steering mechanisms
    • A61B2017/00323—Cables or rods
    • A61B2017/00327—Cables or rods with actuating members moving in opposite directions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Needle structure (l) comprising a hollow cannula (2) and a stylet (3) with a body (4) and a solid front end (5), which stylet (3) is mountable in, and retractable from the hollow cannula (2), wherein the body (4) of the stylet (3) 5 comprises stylet members (6, 7) that are adjacent to each oth— er and are movable with respect to each other and that connect to each other at the solid front end (5) of the stylet (3) protruding from the cannula (2), wherein the stylet members (6, 7) are fixed at or near a proximal end (11) of the stylet 10 (3) which is distant from the solid front end (5) and are mu— tually separated from each other by a slit (l3) or slits ex— tending uninterruptedly from the proximal end (11) to the sol— id front end (5) of the stylet (3).

Description

Needle structure comprising a hollow cannula and a stylet The invention relates to a needle structure compris- ing a hollow cannula and a stylet with a body and a solid front end, which stylet is mountable in, and retractable from the hollow cannula.
There is a need for a steerable needle mechanism, which is attuned to approach a particular lesion or body part of a patient, and which is therefore able to compensate for needle path disturbances and needle deflections, such as those caused by physiological processes of the patient or by needle slipping, buckling or deflecting in an unpredictable interac- tion with the tissue environment. Needle path disturbances oc- cur during diagnosis, e.g. biopsies, as well as during treat- ments, including those in which radio-frequency ablation nee- dles are used. An accurate localization and placement of the needle structure at the body part to be treated is neverthe- less essential. This is a challenge which is exemplified by the example of taking biopsies or treating liver diseases wherein the orientation or position of the liver is unstable due to the patient’s breathing.
The prior art teaches several approaches to answer to the above mentioned need.
A particular needle structure is for instance known from US2004/0133168. In this known needle structure a pre- curved stylet is applied which assumes its curvature when pro- gressing beyond the farthest end of the cannula. When retract- ed into the cannula, the stylet is straightened. The needle structure of US2004/0133168 is proposed in order to make pos- sible that particular body parts of a patient can be reached which are difficult to approach in a straight line.
US2007/0198019 discloses a tissue excision system for performing percutaneous surgery, comprising a cannula and a tissue penetrating member having a distal end defining an ap- erture on one side thereof, an occluding member slidably re- ceived on or in the cannula and closing the aperture when the occluding member is adjacent the cannula distal end, and means for engaging adjacent tissue via the aperture, and cutting means for resecting a section of the engaged tissue.
US2015/0141868 discloses a needle biopsy system in- cluding an actuator device, an outer needle with a lumen therethrough, and an inner needle at least partially disposed within the lumen. The outer needle can extend distally from the actuator device. A distal tip of the inner needle is capa- ble of being fully disposed within the lumen. The inner needle can extend distally from the actuator device and the actuator device is configured to translate the outer needle proximately and distally and independent of the outer needle.
US2016/0100860 discloses an outer tube of an articu- lating punch as well as an inner tube comprising a longitudi- nal slot dividing the tube into two axially oriented parts which are connected at the distal end of the inner tube in ac- cordance with the preamble of claim 1, i.e. disclosing a nee- dle structure comprising a hollow cannula and a stylet with a body and a solid front end, which stylet is mountable in, and retractable from the hollow cannula, wherein the body of the stylet comprises stylet members that are adjacent to each oth- er and are movable with respect to each other and that connect to each other at the solid front end of the stylet protruding from the cannula.
According to the invention a needle structure is pro- posed in accordance with one or more of the appended claims. In a first aspect of the invention the needle struc- ture comprises a hollow cannula and a stylet with a body and a solid front end, which stylet is mountable in, and retractable from the hollow cannula, wherein the body of the stylet com- prises stylet members that are adjacent to each other and are movable with respect to each other and that connect to each other at the solid front end of the stylet protruding from the cannula, and wherein the stylet members are also fixed at or near a proximal end of the stylet which is distant from the solid front end, and the stylet members are mutually separated from each other by a slit or slits extending uninterruptedly from the proximal end to the solid front end of the stylet.
Preferably the needle structure is provided with han- dling means at the proximal end of the stylet for steering the front end of the stylet. It may also be advantageous that the handling means can be fixated in position.
It is possible that at the proximal end of the stylet the stylet members are fixed to each other, or are inde- pendently fixed to said handling means, including (but not limited to) levers, joysticks, flexure joints or to a hand piece provided at or near the proximal end of the stylet.
Accordingly each of said embodiments provides a min- iaturised, monolithic and compliant mechanism, wherein the (longitudinal) slitís) that separate(s) the stylet members ar- range for the possibility that these stylet members may inde- pendently translate in the longitudinal direction of the nee- dle structure and thus steer the front end of the stylet. Upon relative translation of the stylet members with respect to each other, the stylet forms a radius of curvature at the end of the stylet protruding from the cannula. The curvature makes possible that the stylet can be actively attuned to compensate for needle path disturbances within the body of a patient so as to maintain a straight line of progression towards the body part of interest. Curvature amendments are possible on a con- tinuous scale, down to a predefined minimum radius, which may be mechanically imposed. This contrasts with protruding pre- curved stylet inventions, including US2004/0133168, of which the curvature is fixed.
Preferably the front end of the stylet, the stylet members and the stylet members being fixed at the proximal end of the stylet together embody a truss structure, the defor- mation of which is restricted by the cannula, which creates a miniaturised parallelogram mechanism in a planar -or a paral- lelepiped- mechanism in the configuration embodied by the sty- let of the invention.
The absence of laterally protruding holes or slots in the stylet of the needle structure of the invention supports the stiff truss structure. This is notably different from the prior art in which the stylet is purposely weakened to facili- tate tip articulations, e.g. as taught by US2016/0100860. In the invention and in contrast to US2016/0100860, a high flex- ural rigidity is maintained for stable control of the curva- ture of the protruding tip of the stylet in interaction with the protruded tissue, whilst the movability of the stylet mem- bers of the stylet makes possible that the stylet’s curvatureis modified as the need arises, in order to compensate the progression of the needle structure within the body of a pa- tient so as to maintain a straight line of progression towards the body part of interest.
The number of stylet members determines the number of dimensional degrees of freedom in which the protruding part of the stylet can actuate. It is preferred that the needle struc- ture comprises at least two stylet members. When there are two stylet members it is possible to steer in a single plane. It is however more preferable that the needle structure comprises at least three, and preferably four stylet members to make 3D steering possible.
The number of stylet members is determined by the number of slits, and these slits can be of variable size. The slits can be produced with different manufacturing techniques, e.g. 3D printing, or machining techniques, e.g. electric dis- charge machining, laser cutting or milling. The stylet members can have any desired length. In addition, parallel stylet mem- bers may be affixed to external bodies to propagate longitudi- nal displacements. However, it is crucial that each stylet member is fixated at both ends directly or indirectly to at least one other stylet member, that is both at the solid front end, and at the proximal end distant from the front end so as to maintain a stiff truss structure. It is not necessary to fixate all stylet members at both ends to each other, since it may be occasionally helpful to operate with pairs of stylet members wherein each pair has the stylet members of such pair fixated at the proximal end and at the distal end, and wherein each pair can be manipulated with a dedicated hand knob or handle.
Preferably the proximal end of the stylet is outside of the cannula. This provides for the possibility to mount handling means at the proximal end of the stylet for steering the front end of the stylet. The handling means can be provid- ed in several forms, but it is preferred that the handling means is embodied as a lever or as a joystick.
The benefits of the invention are promoted by arrang- ing that the cannula comprises a rigid and unimpaired cannula body. This rigidity secures that the stylet can be manipulatedwith a very high accuracy. It provides a notable difference to the prior solution of US2016/0100860 which requires the appli- cation of slots in the cannula which is therefore not a rigid cannula body. In that known configuration forces that are ap- 5 plied to the cannula cause its bending and make that the lat- eral slots of the cannula are compressed up to the point where the slots close.
The steerability of the needle structure of the in- vention can be further improved in an embodiment wherein at least one of the stylet members of the stylet is provided with at least one weakened portion facing an interior longitudinal axis of the stylet. This at least one weakened portion acts as a joint and because it faces the interior longitudinal axis of the stylet it does not deteriorate the flexural rigidity of the stylet.
Further improvement of the steerability is possible when the wall or stylet members of the stylet is/are provided with a series of weakened portions facing the interior longi- tudinal axis of the stylet. These series of weakened portions shape a collection of joints making flexing of the stylet more controlled and predictable.
The fine structure of the needle structure of the in- vention and the repeatability of the level of its steerability makes it preferable that the weakened portions are regularly distributed. In certain situations, particularly when a de- sired behaviour of the needle structure requires such, it is also possible to irregularly distribute the weakened portions.
The invention will hereinafter be further elucidated with reference to the drawing of an exemplary embodiment of a needle structure according to the invention that is not limit- ing as to the appended claims.
In the drawing: -figure 1 shows a side view of the needle structure of the invention; -figure 2 provides a cross-sectional view at the nee- dle structure of the invention according to the line A - A in figure 1; and -figure 3 shows a detail B of figure 1.
Whenever in the figures the same reference numerals are applied, these numerals refer to the same parts.
Making first reference to figure 3 the needle struc- ture 1 is shown in a detail B of figure 1, and comprises a hollow cannula 2 and a stylet 3 with a body 4 and a solid front end 5.
The stylet 3 is mountable in, and retractable from the hollow cannula 2, and the body 4 of the stylet 3 comprises stylet members 6, 7 that are adjacent to each other and are movable with respect to each other. The stylet members 6, 7 connect to each other at the solid front end 5 of the stylet 3 which protrudes from the cannula 2.
The stylet members 6, 7 are mutually separated from each other by a slit 13 or slits extending uninterruptedly from a proximal end 11 of the needle structure 1 as shown in figures 1 and 2, to the solid front end 5 of the stylet 3.
As is best seen in figure 2 the stylet members 6, 7 are fixed at or near a proximal end 11 of the stylet 3 which is distant from the solid front end 5 to fixtures 16, 17 that in turn connect to springs 8, 9. As the figure shows the prox- imal end 11 of the stylet 3 is outside of the cannula 2.
The fixtures 16, 17 and the stylet members 6, 7 are movable with respect to each other in a longitudinal direction A of the needle structure 1. The fixtures 16, 17 preferably connect to handling means 10 at the proximal end 11 of the stylet 3 for steering the front end 5 of the stylet 3. To make this possible the handling means 10 are swivable around a swivel point 10’, and said handling means 10 connects through intermediary piece 14 to the fixture 16 of one stylet member 6, and through intermediary piece 15 to the fixture 17 of the other stylet member 7. The construction according to the in- vention thus provides that the front end 5 of the stylet 3, the stylet members 6, 7 and the stylet members being fixed to fixtures 16, 17 at the proximal end 11 of the stylet 3 togeth- er embody a truss structure, the deformation of which is re- stricted by the cannula 2.
The handling means 10 is preferably embodied as a lever or as a joystick. It may be beneficial that the handling means 10 can be fixated in position.
In the shown embodiment the needle structure 1 com- prises four stylet members, wherein only two stylet members &, 7 are visible in the shown cross-section. Occasionally it may be desirable that the needle structure 1 comprises at least three, but in any case at least two stylet members.
Figure 3 shows that the stylet members 6, 7 of the body 4 of the stylet 3 are provided with at least one weakened portion 12 facing an interior longitudinal axis of the stylet
3. In the shown embodiment the stylet members 6, 7 of the body 4 of the stylet 3 are provided with a series of weakened por- tions 12 facing an interior longitudinal axis of the stylet 3, which are regularly distributed. An irregular distribution of these weakened portions is however also possible, as well as different sizing of these weakened portions.
Although the invention has been discussed in the foregoing with reference to an exemplary embodiment of the needle structure of the invention, the invention is not re- stricted to the discussed particular embodiments which can be varied in many ways without departing from the invention. The discussed exemplary embodiments shall therefore not be used to construe the appended claims strictly in accordance therewith. On the contrary the embodiments are merely intended to explain the wording of the appended claims without intent to limit the claims to these exemplary embodiments. The scope of protection of the invention shall therefore be construed in accordance with the appended claims only, wherein a possible ambiguity in the wording of the claims shall be resolved using these exem- plary embodiments.
Aspects of the inventions are itemized in the follow- ing section.
1. Needle structure (1) comprising a hollow cannula (2) and a stylet (3) with a body (4) and a solid front end (5), which stylet (3) is mountable in, and retractable from the hollow cannula (2), wherein the body (4) of the stylet (3) comprises stylet members (6, 7) that are adjacent to each other and are movable with respect to each other and that connect to each other at the solid front end (5) of the stylet (3) protruding from the cannula (2), characterized in that the stylet members {6, 7) are fixed at or near a proximal end (11) of the stylet
(3) which is distant from the solid front end (5) and that said stylet members (6, 7) are mutually separated from each other by a slit or slits extending uninterruptedly from the proximal end (11) to the solid front end (5) of the stylet (3).
2. Needle structure according to claim 1, characterized in that the needle structure (1) is provided with handling means (10) at or near the proximal end (11) of the stylet (3) for steering the front end (5) of the stylet (3).
3. Needle structure according to claim 2, characterized in that the handling means (10) can be fixated in position.
4. Needle structure according to claim 2 or 3, characterized in that the front end (5) of the stylet (3), the stylet mem- bers (6, 7) and the styling members being fixed at the proxi- mal end (11) of the stylet (3) together embody a truss struc- ture, the deformation of which is restricted by the cannula (2).
5. Needle structure according to any one of claims 2 - 4, characterized in that the handling means (10) is embodied as a lever or as a joystick.
6. Needle structure according to any one of claims 1 - 5, characterized in that the needle structure (1) comprises at least two stylet members (6, 7).
7. Needle structure according to any one of claims 1 - 6, characterized in that the needle structure (1) comprises at least three, and preferably four stylet members.
8. Needle structure according to any one of claims 1 - 7, characterized in that the proximal end (11) of the stylet (3) is outside of the cannula (2).
9. Needle structure according to any one of claims 1 - 8, characterized in that the stylet members (6, 7) of the body (4) of the stylet (3) are provided with at least one weakened portion (12) facing an interior longitudinal axis of the sty- let (3).
10. Needle structure according to any one of claims 1 - 9, characterized in that the stylet members (6, 7) of the body (4) of the stylet (3) are provided with a series of weakened portions (12) facing an interior longitudinal axis of the sty- let (3).
11. Needle structure according to claim 10, characterized in that the weakened portions (12) are regularly distributed.

Claims (11)

CONCLUSIESCONCLUSIONS 1. Naaldstructuur (1) omvattende een holle cannula (2) en een stylet (3) met een lichaam (4) en een vast vooruit- einde (5), welke stylet (3) monteerbaar is en uitneembaar is uit de holle cannula (2), waarbij het lichaam (4) van de sty- let (3) styletdelen (6, 7) omvat die naast elkaar liggen en ten opzichte van elkaar beweegbaar zijn en die met elkaar ver- bonden zijn aan het vaste vooruiteinde (5) van de stylet (3) dat uit de cannula (2) uitsteekt, met het kenmerk, dat de sty- letdelen (6, 7) vastgemaakt zijn bij of nabij een proximaal uiteinde (11) van de stylet (3) welke afgelegen is van het vaste vooruiteinde (5) en dat genoemde styletdelen (6, 7) on- derling van elkaar gescheiden zijn door een sleuf of sleuven die ononderbroken verlopen van het proximale uiteinde (11) naar het vaste vooruiteinde (5) van de stylet (3).Needle structure (1) comprising a hollow cannula (2) and a stylet (3) with a body (4) and a fixed forward end (5), which stylet (3) is mountable and removable from the hollow cannula ( 2), wherein the body (4) of the stylet (3) comprises stylet parts (6, 7) which are adjacent and movable with respect to each other and which are joined together at the fixed front end (5) of the stylet (3) protruding from the cannula (2), characterized in that the stylet parts (6, 7) are attached at or near a proximal end (11) of the stylet (3) which is remote from the fixed front end (5) and that said stylet parts (6, 7) are separated from each other by a slot or slots running continuously from the proximal end (11) to the fixed front end (5) of the stylet (3) . 2. Naaldstructuur volgens conclusie 1, met het ken- merk, dat de naaldstructuur (1) voorzien is van hanteermidde- len (10) bij of nabij het proximale uiteinde (11) van de sty- let (3) voor het sturen van het vooruiteinde (5) van de stylet (3).Needle structure according to claim 1, characterized in that the needle structure (1) is provided with handling means (10) at or near the proximal end (11) of the stylet (3) for steering the needle. front end (5) of the stylet (3). 3. Naaldstructuur volgens conclusie 2, met het ken- merk, dat de hanteermiddelen (10) in positie vastgezet kunnen worden.Needle structure according to claim 2, characterized in that the handling means (10) can be fixed in position. 4. Naaldstructuur volgens conclusie 2 of 3, met het kenmerk, dat het vooruiteinde (5) van de stylet (3), de sty- letdelen (6, 7), en de styletdelen die vastgemaakt zijn aan het proximale uiteinde (11) van de stylet (3) samen een truss- structuur vormen waarvan de deformatie beperkt wordt door de cannula (2).Needle structure according to claim 2 or 3, characterized in that the front end (5) of the stylet (3), the stylet parts (6, 7), and the stylet parts attached to the proximal end (11) of the stylet (3) together form a truss structure whose deformation is limited by the cannula (2). 5. Naaldstructuur volgens één der conclusies 2-4, met het kenmerk, dat de hanteermiddelen (10) uitgevoerd zijn als een hefboom of als een joystick.Needle structure according to any one of claims 2-4, characterized in that the handling means (10) are designed as a lever or as a joystick. 6. Naaldstructuur volgens één der conclusies 1-5, met het kenmerk, dat de naaldstructuur (1) ten minste twee sty- letdelen (6, 7) omvat.Needle structure according to one of Claims 1 to 5, characterized in that the needle structure (1) comprises at least two stylet parts (6, 7). 7. Naaldstructuur volgens één der conclusies 1-6, met het kenmerk, dat de naaldstructuur (1) ten minste drie en bij voorkeur vier styletdelen omvat.Needle structure according to any one of Claims 1 to 6, characterized in that the needle structure (1) comprises at least three and preferably four stylet parts. 8. Naaldstructuur volgens één der conclusies 1-7, met het kenmerk, dat het proximale uiteinde (11) van de stylet (3) buiten de cannula (2) ligt.Needle structure according to any one of claims 1 to 7, characterized in that the proximal end (11) of the stylet (3) lies outside the cannula (2). 9. Naaldstructuur volgens één der conclusies 1-8, met het kenmerk, dat de styletdelen (6, 7) van het lichaam (4) van de stylet (3) voorzien zijn van ten minste één verzwakt deel {12) dat gericht is naar een binnengelegen longitudinale as van de stylet (3).Needle structure according to any one of claims 1 to 8, characterized in that the stylet parts (6, 7) of the body (4) of the stylet (3) are provided with at least one weakened part (12) facing towards an inner longitudinal axis of the stylet (3). 10. Naaldstructuur volgens één der conclusies 1-9, met het kenmerk, dat de styletdelen (6, 7) van het lichaam (4) van de stylet (3) voorzien zijn van een serie verzwakte delen (12) die gericht zijn naar een binnengelegen longitudinale as van de stylet (3).Needle structure according to any one of claims 1 to 9, characterized in that the stylet parts (6, 7) of the body (4) of the stylet (3) are provided with a series of weakened parts (12) facing a inner longitudinal axis of the stylet (3). 11. Naaldstructuur volgens conclusie 10, met het ken- merk, dat de verzwakte delen (12) regelmatig verdeeld zijn.Needle structure according to claim 10, characterized in that the weakened parts (12) are regularly distributed.
NL2022314A 2018-12-27 2018-12-27 Needle structure comprising a hollow cannula and a stylet NL2022314B1 (en)

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NL2022314A NL2022314B1 (en) 2018-12-27 2018-12-27 Needle structure comprising a hollow cannula and a stylet
PCT/NL2019/050846 WO2020139083A1 (en) 2018-12-27 2019-12-17 Needle structure comprising a hollow cannula and a stylet

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