NL1036784C2 - A three-dimensional bifurcating micro-channel construct for regenerative bidirectional neuro-electric interfacing. - Google Patents
A three-dimensional bifurcating micro-channel construct for regenerative bidirectional neuro-electric interfacing. Download PDFInfo
- Publication number
- NL1036784C2 NL1036784C2 NL1036784A NL1036784A NL1036784C2 NL 1036784 C2 NL1036784 C2 NL 1036784C2 NL 1036784 A NL1036784 A NL 1036784A NL 1036784 A NL1036784 A NL 1036784A NL 1036784 C2 NL1036784 C2 NL 1036784C2
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- Netherlands
- Prior art keywords
- nerve
- neurites
- microchannels
- micro
- wells
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0556—Cuff electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Prostheses (AREA)
Description
A three-dimensional bifurcating micro-channel construct for regenerative bidirectional neuro-electric interfacing
SUMMARY OF INVENTION
5 The following describes a proposed implantable biomedical device that establishes bi-directional communication between the human peripheral nervous system (PNS) and a neuroprosthesis. This provides a user with intuitive control over, and feedback from, a prosthetic device, effectively replacing the lost function which the prosthesis replaces. This approach is particularly suited when trying to effectively interface with a PNS fascicle containing ‘mixed’ neurons, meaning both 10 afferent (sensory) and efferent (motor) neurons.
The neurons of the PNS are known to regenerate into surrounding tissue of the amputation site, attempting to find appropriate target tissue to innervate. They do so in a bundling manner, making it difficult to differentiate individual neurons and associated action potentials.
15
Figure 1 shows one representation of the intended device, which takes the form of a biocompatible polymer end cap (1) which is fitted over the end of a recently severed fascicle (3) of the PNS. The end cap provides an alternative extracellular environment of micro-channels (4) into which neurons (5) can regenerate in a controlled manner.
20
Figure 2 represents a formation of the micro-channel networks shown in Figure 1. The round microchannels (4) initially begin large (approximately 100 pm diameter) to encourage neural ingrowth into the device. These channels proceed through a series of bifurcations (10), becoming progressively smaller with each division (down to 2.5 pm in diameter) such that ingrowing neurons 25 are encouraged to separate from one another with the eventual goal that single neurons populate single micro-channels.
The micro-channels guide these individual neurons toward micro-well chambers (6) containing appropriate innervation target tissue (7). This is required to ensure the long term survival of 30 ingrowing neurons. The innervation target tissue can consist of either a pre-cultured neural probe of intemeurons or of pre-cultured smooth muscle. Electrical contact is made with the neurons either via electrodes placed within the micro-channels (8) en route to the micro-well chambers, taking 1036784 2 advantage of single amplification of action potentials that occurs within a micro-channel, or through electrodes located within the micro-well (9), using the target tissue as the intermediate signal interface and possible signal amplifier.
5 The final proposal is to achieve a one-to-one relationship between electrodes and neurons within a fascicle - or as close as possible to a one-to-one mapping. This device effectively separates out the constituent parts of a fascicle and establishes a strong, stable and long-term contact with each separate neuron. It allows for improved ‘graded’ motor responses of a neuroprosthesis based on the activation of more and more neurons, which is easily measured with this device as more electrode 10 sites become active. Also, in the case of a sensory neuron, total sensory response can be restored as each neuron associated with a specific sensory role can be reassigned accordingly to accept signals from an equivalent sensing mechanism in the neuroprosthetic device.
The micro-channel walls can be coated with a biocompatible polymer. This reduces the size of the 15 micro-channels, thus encouraging a greater degree of separation via volume limitation and also provides a medium for bioactivation via the integration of appropriate biomolecules within the polymer matrix.
To further promote neural ingrowth, the micro-channels can be seeded with Schwann cells to further 20 enhance the recreation of the endoneurial tubes into which neurons regenerate into in the optimal natural setting. A bifurcating pattern of linear groove microstructures may also be incorporated on the surface of the micro-channels, mimicking the fine longitudinal collagen structures lining the endoneurial tubes. These can be placed before each micro-channel bifurcation in a diverging pattern to further encourage neuron separation.
25 1036784
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1036784A NL1036784C2 (en) | 2009-03-30 | 2009-03-30 | A three-dimensional bifurcating micro-channel construct for regenerative bidirectional neuro-electric interfacing. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1036784 | 2009-03-30 | ||
NL1036784A NL1036784C2 (en) | 2009-03-30 | 2009-03-30 | A three-dimensional bifurcating micro-channel construct for regenerative bidirectional neuro-electric interfacing. |
Publications (1)
Publication Number | Publication Date |
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NL1036784C2 true NL1036784C2 (en) | 2010-10-04 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NL1036784A NL1036784C2 (en) | 2009-03-30 | 2009-03-30 | A three-dimensional bifurcating micro-channel construct for regenerative bidirectional neuro-electric interfacing. |
Country Status (1)
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NL (1) | NL1036784C2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014130419A1 (en) * | 2013-02-19 | 2014-08-28 | Board Of Regents, The University Of Texas System | Devices and methods for the prevention and treatment of neuromas |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002078592A2 (en) * | 2001-03-30 | 2002-10-10 | Case Western Reserve University | Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses |
US20030018367A1 (en) * | 2001-07-23 | 2003-01-23 | Dilorenzo Daniel John | Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease |
WO2009003025A2 (en) * | 2007-06-25 | 2008-12-31 | Microtransponder, Inc. | Grooved electrode and wireless microtransponder system |
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2009
- 2009-03-30 NL NL1036784A patent/NL1036784C2/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002078592A2 (en) * | 2001-03-30 | 2002-10-10 | Case Western Reserve University | Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses |
US20030018367A1 (en) * | 2001-07-23 | 2003-01-23 | Dilorenzo Daniel John | Method and apparatus for neuromodulation and phsyiologic modulation for the treatment of metabolic and neuropsychiatric disease |
WO2009003025A2 (en) * | 2007-06-25 | 2008-12-31 | Microtransponder, Inc. | Grooved electrode and wireless microtransponder system |
Non-Patent Citations (1)
Title |
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LARS WALLMAN * ET AL: "Perforated Silicon Nerve Chips with Doped Registration Electrodes: in Vitro Performance and in Vivo Operation", IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, IEEE SERVICE CENTER, PISCATAWAY, NJ, US, vol. 46, no. 9, 1 September 1999 (1999-09-01), XP011006762, ISSN: 0018-9294 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014130419A1 (en) * | 2013-02-19 | 2014-08-28 | Board Of Regents, The University Of Texas System | Devices and methods for the prevention and treatment of neuromas |
US9950099B2 (en) | 2013-02-19 | 2018-04-24 | Board Of Regents, The University Of Texas System | Devices and methods for the prevention and treatment of neuromas |
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V1 | Lapsed because of non-payment of the annual fee |
Effective date: 20131001 |