NI201000176A - 2,6-DIAMINO-PYRIMIDIN-5-IL-CARBOXAMIDES AS INHIBITORS OF SYK OR JAK KINASES. - Google Patents
2,6-DIAMINO-PYRIMIDIN-5-IL-CARBOXAMIDES AS INHIBITORS OF SYK OR JAK KINASES.Info
- Publication number
- NI201000176A NI201000176A NI201000176A NI201000176A NI201000176A NI 201000176 A NI201000176 A NI 201000176A NI 201000176 A NI201000176 A NI 201000176A NI 201000176 A NI201000176 A NI 201000176A NI 201000176 A NI201000176 A NI 201000176A
- Authority
- NI
- Nicaragua
- Prior art keywords
- syk
- inhibitors
- methods
- carboxamides
- pyrimidin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invención se dirige a compuestos de la Fórmula I-II y tautómeros, sales o estereoisómeros farmacéuticamente aceptables de la misma que son inhibidores de syk y/o JAK quinasas. La presente invención también se dirige a intermediarios usados para realizar dichos compuestos, a la preparación de dicho compuesto, composiciones farmacéuticas que contienen dicho compuesto, métodos de inhibición de syk y/o JAK quinasa, métodos para la inhibición de agregación de plaquetas, y métodos para evitar o tratar una cantidad de enfermedades mediadas, al menos en parte, por la actividad syk y/o JAK quinasa, como por ejemplo trombosis y Linfoma no- Hodgkin.The present invention is directed to compounds of Formula I-II and pharmaceutically acceptable tautomers, salts or stereoisomers thereof which are inhibitors of syk and / or JAK kinases. The present invention is also directed to intermediates used to make said compounds, to the preparation of said compound, pharmaceutical compositions containing said compound, methods of inhibiting syk and / or JAK kinase, methods for inhibiting platelet aggregation, and methods to prevent or treat a number of diseases mediated, at least in part, by syk and / or JAK kinase activity, such as thrombosis and Non-Hodgkin's Lymphoma.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4539908P | 2008-04-16 | 2008-04-16 | |
US4541708P | 2008-04-16 | 2008-04-16 | |
US4540608P | 2008-04-16 | 2008-04-16 | |
US12034108P | 2008-12-05 | 2008-12-05 | |
US12034408P | 2008-12-05 | 2008-12-05 | |
US12034808P | 2008-12-05 | 2008-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201000176A true NI201000176A (en) | 2011-08-08 |
Family
ID=43570275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201000176A NI201000176A (en) | 2008-04-16 | 2010-10-15 | 2,6-DIAMINO-PYRIMIDIN-5-IL-CARBOXAMIDES AS INHIBITORS OF SYK OR JAK KINASES. |
Country Status (18)
Country | Link |
---|---|
AU (1) | AU2009251863B2 (en) |
BR (1) | BRPI0910560B8 (en) |
CO (1) | CO6331433A2 (en) |
CY (1) | CY1118559T1 (en) |
DK (1) | DK2321283T3 (en) |
ES (1) | ES2597441T3 (en) |
GT (1) | GT201000298A (en) |
HK (1) | HK1158179A1 (en) |
HU (1) | HUE031638T2 (en) |
IL (3) | IL208637A (en) |
LT (1) | LT2321283T (en) |
MX (1) | MX353206B (en) |
NI (1) | NI201000176A (en) |
NZ (1) | NZ589314A (en) |
PL (1) | PL2321283T3 (en) |
PT (1) | PT2321283T (en) |
SI (1) | SI2321283T1 (en) |
ZA (1) | ZA201007045B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102083800A (en) | 2008-06-27 | 2011-06-01 | 阿维拉制药公司 | Heteroaryl compounds and uses thereof |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
AU2013202496B2 (en) * | 2008-06-27 | 2016-08-04 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
EP3144298A1 (en) | 2010-08-10 | 2017-03-22 | Celgene Avilomics Research, Inc. | Besylate salt of a btk inhibitor |
US9561228B2 (en) | 2013-02-08 | 2017-02-07 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
EP3179858B1 (en) | 2014-08-13 | 2019-05-15 | Celgene Car Llc | Forms and compositions of an erk inhibitor |
CN114196651B (en) * | 2021-12-15 | 2023-06-30 | 中国林业科学研究院亚热带林业研究所 | New application of D6 protein kinase D6PKL2 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1054004B1 (en) * | 1997-12-15 | 2008-07-16 | Astellas Pharma Inc. | Novel pyrimidine-5-carboxamide derivatives |
WO2004002964A1 (en) * | 2002-06-28 | 2004-01-08 | Yamanouchi Pharmaceutical Co., Ltd. | Diaminopyrimidinecarboxa mide derivative |
AU2007276369A1 (en) * | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as JAK kinases inhibitors |
-
2009
- 2009-04-16 BR BRPI0910560A patent/BRPI0910560B8/en active IP Right Grant
- 2009-04-16 PT PT97552194T patent/PT2321283T/en unknown
- 2009-04-16 PL PL09755219T patent/PL2321283T3/en unknown
- 2009-04-16 HU HUE09755219A patent/HUE031638T2/en unknown
- 2009-04-16 ES ES09755219.4T patent/ES2597441T3/en active Active
- 2009-04-16 NZ NZ589314A patent/NZ589314A/en not_active IP Right Cessation
- 2009-04-16 DK DK09755219.4T patent/DK2321283T3/en active
- 2009-04-16 MX MX2010011464A patent/MX353206B/en active IP Right Grant
- 2009-04-16 LT LTEP09755219.4T patent/LT2321283T/en unknown
- 2009-04-16 SI SI200931540A patent/SI2321283T1/en unknown
- 2009-04-16 AU AU2009251863A patent/AU2009251863B2/en active Active
-
2010
- 2010-10-04 ZA ZA2010/07045A patent/ZA201007045B/en unknown
- 2010-10-11 IL IL208637A patent/IL208637A/en active IP Right Grant
- 2010-10-15 NI NI201000176A patent/NI201000176A/en unknown
- 2010-10-15 GT GT201000298A patent/GT201000298A/en unknown
- 2010-11-16 CO CO10143190A patent/CO6331433A2/en active IP Right Grant
-
2011
- 2011-11-16 HK HK11112350.6A patent/HK1158179A1/en not_active IP Right Cessation
-
2016
- 2016-10-13 CY CY20161101026T patent/CY1118559T1/en unknown
-
2017
- 2017-04-09 IL IL251655A patent/IL251655B/en active IP Right Grant
-
2020
- 2020-05-07 IL IL274522A patent/IL274522A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUE031638T2 (en) | 2017-07-28 |
CY1118559T1 (en) | 2017-07-12 |
IL208637A0 (en) | 2010-12-30 |
HK1158179A1 (en) | 2012-07-13 |
AU2009251863A1 (en) | 2009-12-03 |
BRPI0910560B1 (en) | 2023-01-24 |
IL251655B (en) | 2020-05-31 |
ZA201007045B (en) | 2012-08-29 |
IL251655A0 (en) | 2017-06-29 |
MX2010011464A (en) | 2014-06-16 |
GT201000298A (en) | 2014-05-07 |
AU2009251863B2 (en) | 2014-09-25 |
BRPI0910560A2 (en) | 2021-04-27 |
SI2321283T1 (en) | 2017-01-31 |
AU2009251863A2 (en) | 2011-06-09 |
MX353206B (en) | 2018-01-08 |
BRPI0910560B8 (en) | 2023-03-21 |
DK2321283T3 (en) | 2016-10-31 |
LT2321283T (en) | 2016-12-12 |
IL274522A (en) | 2020-06-30 |
ES2597441T3 (en) | 2017-01-18 |
NZ589314A (en) | 2012-10-26 |
PL2321283T3 (en) | 2017-01-31 |
IL208637A (en) | 2017-04-30 |
CO6331433A2 (en) | 2011-10-20 |
PT2321283T (en) | 2016-10-19 |
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