MY197126A - Nanocarrier delivery system for hydrophobic substances - Google Patents

Nanocarrier delivery system for hydrophobic substances

Info

Publication number
MY197126A
MY197126A MYPI2015700198A MYPI2015700198A MY197126A MY 197126 A MY197126 A MY 197126A MY PI2015700198 A MYPI2015700198 A MY PI2015700198A MY PI2015700198 A MYPI2015700198 A MY PI2015700198A MY 197126 A MY197126 A MY 197126A
Authority
MY
Malaysia
Prior art keywords
delivery system
hydrophobic substances
nanocarrier delivery
nanoparticles
cancer
Prior art date
Application number
MYPI2015700198A
Inventor
Ju Yen Fu
Tan Meam Yee Doryn
Nesaretnam Kalanithi
Original Assignee
Malaysian Palm Oil Board
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Malaysian Palm Oil Board filed Critical Malaysian Palm Oil Board
Priority to MYPI2015700198A priority Critical patent/MY197126A/en
Priority to PCT/MY2016/050004 priority patent/WO2016118001A1/en
Priority to AU2016209724A priority patent/AU2016209724B2/en
Priority to GB1713495.8A priority patent/GB2551453B/en
Priority to CN201680017476.3A priority patent/CN107427471B/en
Publication of MY197126A publication Critical patent/MY197126A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A nanocarrier delivery system for hydrophobic substances comprising a composition of nanoparticles. The nanoparticle comprises a surfactant of ascorbyl palmitate, a cholesterol, a hydrophilic polymer, a functionalized polymer containing a carboxylic end group, a chemical linker and a targeting protein. A method of producing the nanoparticles and the use of the nanoparticle for the manufacture of a pharmaceutical in the treatment and/or prevention of cancer and cancer related conditions.
MYPI2015700198A 2015-01-23 2015-01-23 Nanocarrier delivery system for hydrophobic substances MY197126A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
MYPI2015700198A MY197126A (en) 2015-01-23 2015-01-23 Nanocarrier delivery system for hydrophobic substances
PCT/MY2016/050004 WO2016118001A1 (en) 2015-01-23 2016-01-21 Nanocarrier delivery system for hydrophobic substances
AU2016209724A AU2016209724B2 (en) 2015-01-23 2016-01-21 Nanocarrier delivery system for hydrophobic substances
GB1713495.8A GB2551453B (en) 2015-01-23 2016-01-21 Nanocarrier delivery system for hydrophobic substances
CN201680017476.3A CN107427471B (en) 2015-01-23 2016-01-21 Nanocarrier delivery systems for hydrophobic substances

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI2015700198A MY197126A (en) 2015-01-23 2015-01-23 Nanocarrier delivery system for hydrophobic substances

Publications (1)

Publication Number Publication Date
MY197126A true MY197126A (en) 2023-05-26

Family

ID=56417447

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2015700198A MY197126A (en) 2015-01-23 2015-01-23 Nanocarrier delivery system for hydrophobic substances

Country Status (5)

Country Link
CN (1) CN107427471B (en)
AU (1) AU2016209724B2 (en)
GB (1) GB2551453B (en)
MY (1) MY197126A (en)
WO (1) WO2016118001A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019094625A1 (en) * 2017-11-09 2019-05-16 Nexien Biopharma, Inc. Methods and compositions for parenteral administration of cannabidiol in the treatment of convulsive disorders
US20220023450A1 (en) * 2018-09-11 2022-01-27 Memorial Sloan Kettering Cancer Center Bone marrow-, reticuloendothelial system-, and/or lymph node-targeted radiolabeled liposomes and methods of their diagnostic and therapeutic use
CN112180079B (en) * 2020-09-25 2024-04-19 上海睿康生物科技有限公司 Stable liposome particle and application thereof in immune turbidimetry detection
CN113318217A (en) * 2021-06-02 2021-08-31 厦门大学 BTZ-TPGS compound, nano preparation, preparation and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003053407A1 (en) * 2001-12-19 2003-07-03 Research Development Foundation Liposomal delivery of vitamin e based compounds
CN101569607B (en) * 2009-06-16 2011-02-16 中国药科大学 Di-demethoxycurcumin precursor liposome and preparation method thereof

Also Published As

Publication number Publication date
GB201713495D0 (en) 2017-10-04
CN107427471A (en) 2017-12-01
GB2551453B (en) 2020-09-09
AU2016209724A1 (en) 2017-09-14
AU2016209724B2 (en) 2021-03-11
CN107427471B (en) 2020-07-31
GB2551453A (en) 2017-12-20
WO2016118001A1 (en) 2016-07-28

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