MY188058A - Inhibitors of kras g12c - Google Patents

Inhibitors of kras g12c

Info

Publication number
MY188058A
MY188058A MYPI2016701035A MYPI2016701035A MY188058A MY 188058 A MY188058 A MY 188058A MY PI2016701035 A MYPI2016701035 A MY PI2016701035A MY PI2016701035 A MYPI2016701035 A MY PI2016701035A MY 188058 A MY188058 A MY 188058A
Authority
MY
Malaysia
Prior art keywords
compounds
inhibitors
kras
activity
mutant kras
Prior art date
Application number
MYPI2016701035A
Inventor
Liansheng Li
Jun Feng
Tao Wu
Pingda Ren
Yi Liu
Yuan Liu
Yun Oliver Long
Original Assignee
Araxes Pharma Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JOP/2014/0289A external-priority patent/JO3805B1/en
Application filed by Araxes Pharma Llc filed Critical Araxes Pharma Llc
Priority claimed from PCT/US2014/060036 external-priority patent/WO2015054572A1/en
Publication of MY188058A publication Critical patent/MY188058A/en

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Abstract

Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): (I) or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided. (Figure 3)
MYPI2016701035A 2013-10-10 2014-10-10 Inhibitors of kras g12c MY188058A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361889460P 2013-10-10 2013-10-10
US201462034619P 2014-08-07 2014-08-07
US201461052366P 2014-09-18 2014-09-18
JOP/2014/0289A JO3805B1 (en) 2013-10-10 2014-10-09 Inhibitors of kras g12c
TW103135318A TWI659021B (en) 2013-10-10 2014-10-09 Inhibitors of kras g12c
PCT/US2014/060036 WO2015054572A1 (en) 2013-10-10 2014-10-10 Inhibitors of kras g12c

Publications (1)

Publication Number Publication Date
MY188058A true MY188058A (en) 2021-11-15

Family

ID=81329896

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2016701035A MY188058A (en) 2013-10-10 2014-10-10 Inhibitors of kras g12c

Country Status (1)

Country Link
MY (1) MY188058A (en)

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