MY187515A - Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration - Google Patents

Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration

Info

Publication number
MY187515A
MY187515A MYPI2017000688A MYPI2017000688A MY187515A MY 187515 A MY187515 A MY 187515A MY PI2017000688 A MYPI2017000688 A MY PI2017000688A MY PI2017000688 A MYPI2017000688 A MY PI2017000688A MY 187515 A MY187515 A MY 187515A
Authority
MY
Malaysia
Prior art keywords
tissue
repair
alkenyl
alkyl
regeneration
Prior art date
Application number
MYPI2017000688A
Inventor
Gagnon Lyne
Laurin Pierre
Original Assignee
Prometic Pharma Smt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometic Pharma Smt Ltd filed Critical Prometic Pharma Smt Ltd
Publication of MY187515A publication Critical patent/MY187515A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Described herein are compounds of Formula I, or pharmaceutically acceptable salts thereof, or combinations thereof, as well as uses thereof. Such uses include promoting tissue self-repair or tissue regeneration of an organ, stimulating the generation of tissue growth, modulating (e.g. increasing) the level of a tissue-repair marker, treating physical injury in an organ, tissue, or cell, promoting wound healing as well as anti-aging applications. Corresponding compositions, methods and uses are also described. Formula I wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)-(CH2)n-CH3 or CH(OH)-(CH2)n- CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is H, F, OH, C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R3 is H, F, OH, or CH2Ph; R4 is H, F or OH; Q is 1) (CH2),C(O)OH wherein m is 1 or 2 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)-C(O)OH, 5) CF2-C(O)OH or 6) C(O)-C(O)OH. (no suitable figure)
MYPI2017000688A 2014-11-12 2015-11-12 Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration MY187515A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462078704P 2014-11-12 2014-11-12
PCT/CA2015/000572 WO2016074068A1 (en) 2014-11-12 2015-11-12 Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration

Publications (1)

Publication Number Publication Date
MY187515A true MY187515A (en) 2021-09-24

Family

ID=55953490

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2017000688A MY187515A (en) 2014-11-12 2015-11-12 Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration

Country Status (19)

Country Link
US (3) US10391073B2 (en)
EP (1) EP3217968A4 (en)
JP (1) JP6720169B2 (en)
KR (1) KR20170072352A (en)
CN (1) CN107106526B (en)
AR (1) AR102634A1 (en)
AU (2) AU2015345943B2 (en)
BR (1) BR112017009899A2 (en)
CA (1) CA2967499C (en)
IL (1) IL252221B (en)
MX (1) MX381687B (en)
MY (1) MY187515A (en)
PH (1) PH12017500856A1 (en)
RU (1) RU2728782C2 (en)
SG (1) SG11201703741TA (en)
TW (1) TWI723967B (en)
UY (1) UY36399A (en)
WO (1) WO2016074068A1 (en)
ZA (1) ZA201703579B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI742541B (en) * 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 Substituted aromatic compounds for the treatment of pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis
AR102634A1 (en) * 2014-11-12 2017-03-15 Prometic Biosciences Inc AROMATIC COMPOUNDS REPLACED AND PHARMACEUTICAL COMPOSITIONS FOR THE SELF-REPAIR AND REGENERATION OF THE FABRIC

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2289417C1 (en) * 2005-04-15 2006-12-20 Равиль Шамилевич Мирхайдаров Method for biological skin rejuvenation
EP1953222A1 (en) * 2007-01-24 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Improvement of cell growth
PT2427416E (en) 2009-05-04 2016-06-15 Prometic Pharma Smt Ltd SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USES
EP2427417B1 (en) * 2009-05-04 2013-10-09 ProMetic BioSciences Inc. Salts of 3-pentylphenylacetic acid and pharmaceutical uses thereof
ES2351005B1 (en) * 2009-07-10 2011-11-18 Consejo Superior De Investigaciones Científicas (Csic) USE OF CARBONIC ANHYDRASE II FOR THE PREPARATION OF A MEDICINAL PRODUCT.
US20130225683A1 (en) * 2010-10-27 2013-08-29 Prometic Biosciences Inc. Compounds and Pharmaceutical Compositions for Uses in Diabetes
DK2632452T3 (en) * 2010-10-27 2019-01-21 Prometic Pharma Smt Ltd RELATIONSHIPS AND COMPOSITIONS FOR CANCER TREATMENT
ES2664816T3 (en) * 2010-10-27 2018-04-23 Prometic Pharma Smt Limited Phenyl ketone carboxylate compounds and pharmaceutical uses thereof
JP5388233B2 (en) * 2011-01-19 2014-01-15 富士ソフト株式会社 Method for evaluating the cartilage characteristics of regenerated cartilage
JP2014522879A (en) * 2011-08-10 2014-09-08 ディグナ ビオテク、エセ エレ Use of cardiotrophin-1 for the treatment of kidney disease
TWI742541B (en) 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 Substituted aromatic compounds for the treatment of pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis
TWI689490B (en) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 Substituted aromatic compounds for the treatment of fibrosis and related methods
WO2016054728A1 (en) * 2014-10-10 2016-04-14 Prometic Biosciences Inc. Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis
CA2963276A1 (en) * 2014-10-10 2016-04-14 Prometic Biosciences Inc. Substituted aromatic compounds and pharmaceutical compositions for the prevention and treatment of diabetes
AR102634A1 (en) * 2014-11-12 2017-03-15 Prometic Biosciences Inc AROMATIC COMPOUNDS REPLACED AND PHARMACEUTICAL COMPOSITIONS FOR THE SELF-REPAIR AND REGENERATION OF THE FABRIC

Also Published As

Publication number Publication date
US20210085626A1 (en) 2021-03-25
CA2967499A1 (en) 2016-05-19
TWI723967B (en) 2021-04-11
ZA201703579B (en) 2018-08-29
UY36399A (en) 2016-06-30
AU2015345943A1 (en) 2017-06-01
EP3217968A4 (en) 2018-06-20
PH12017500856A1 (en) 2017-11-06
KR20170072352A (en) 2017-06-26
CN107106526B (en) 2021-05-28
US20200078324A1 (en) 2020-03-12
CN107106526A (en) 2017-08-29
US10391073B2 (en) 2019-08-27
RU2728782C2 (en) 2020-07-31
BR112017009899A2 (en) 2018-01-16
IL252221B (en) 2022-04-01
RU2017120401A3 (en) 2019-06-06
US20170312237A1 (en) 2017-11-02
AR102634A1 (en) 2017-03-15
TW201618764A (en) 2016-06-01
CA2967499C (en) 2023-01-17
MX381687B (en) 2025-03-13
AU2015345943B2 (en) 2020-03-19
SG11201703741TA (en) 2017-06-29
JP6720169B2 (en) 2020-07-08
IL252221A0 (en) 2017-07-31
AU2020204112A1 (en) 2020-07-09
MX2017006281A (en) 2017-08-14
US10869849B2 (en) 2020-12-22
AU2020204112B2 (en) 2021-10-21
WO2016074068A1 (en) 2016-05-19
RU2017120401A (en) 2018-12-13
EP3217968A1 (en) 2017-09-20
JP2017533928A (en) 2017-11-16

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