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Application filed by Univ MalayafiledCriticalUniv Malaya
Priority to MYPI2015701122ApriorityCriticalpatent/MY180829A/en
Publication of MY180829ApublicationCriticalpatent/MY180829A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Medicinal Preparation
(AREA)
Abstract
The present invention disclosed a lipid nanoparticles carrier formulation to encapsulate mangostin compounds for better anticancer property. The lipid nanoparticles carrier formulation consists of 50 to 80 wt% of stearic acid and 20 to 50 wt% of oleic acid as the raw material of lipid nanoparticles to encapsulate the mangostin compounds and 0.25 to 2.0 wt% non-ionic surfactant to stabilize the lipid nanoparticles. In a specific embodiment, the mangostin compounds can be generally represented by Molecular Formula (1) or its pharmaceutical acceptable salts, prodrug and solvates thereof. Besides, the present invention also disclosed mangostin compounds loaded lipid nanoparticles and a method of making the same. Molecular Formula (1)