MY153032A - Curcumin compounds with superior structural stability and processes for their preparation thereof - Google Patents

Curcumin compounds with superior structural stability and processes for their preparation thereof

Info

Publication number
MY153032A
MY153032A MYPI2011000320A MY153032A MY 153032 A MY153032 A MY 153032A MY PI2011000320 A MYPI2011000320 A MY PI2011000320A MY 153032 A MY153032 A MY 153032A
Authority
MY
Malaysia
Prior art keywords
curcumin
compounds
processes
preparation
structural stability
Prior art date
Application number
Inventor
Rusli Ismail
Mohamed Ashraf Ali
Tan Soo Choon
Noor Shahida Ajmi
Yeong Keng Yoon
Raju Suresh Kumar
Hasnah Osman
Original Assignee
Univ Sains Malaysia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sains Malaysia filed Critical Univ Sains Malaysia
Priority to MYPI2011000320 priority Critical patent/MY153032A/en
Priority to PCT/MY2011/000175 priority patent/WO2012099452A1/en
Publication of MY153032A publication Critical patent/MY153032A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ACCORDINGLY, THE INVENTION DISCLOSES COMPOUNDS WITH ENHANCED BIOAVAILABILITY FOR THE PREVENTION AND TREATMENT OF ANTI-HUMAN IMMUNODEFICIENCY VIRUS (HIV), ANTI-TUBERCULOSIS (TB), ANTI-ALZHEIMER OR ANTI-CANCER. THE INVENTION ALSO DISCLOSES THE METHOD IN SYNTHESIZING THESE COMPOUNDS WHEREIN THE STEPS INCLUDES MIXING CURCUMIN, ISATIN DERIVATIVES OR NINHYDRIN AND PROLINE IN 20 ML METHANOL. THE MIXTURE WAS THEN REFLUXED WITH A SOLVENT ON A WATER BATH AND EXCESS SOLVENT WAS REMOVED UNDER VACUUM. THE RESIDUE SUBJECTED TO FLASH COLUMN CHROMATOGRAPHY USING PETROLEUM ETHER: ETHYL ACETATE MIXTURE (4:1) AS ELUENT TO AFFORD THE PRODUCT. THE RATIO FOR CURCUMIN: ISATIN DERIVATIVE/NINHYDRIN: PROLINE IS 1:1:2 AND 1:2:4.
MYPI2011000320 2011-01-21 2011-01-21 Curcumin compounds with superior structural stability and processes for their preparation thereof MY153032A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
MYPI2011000320 MY153032A (en) 2011-01-21 2011-01-21 Curcumin compounds with superior structural stability and processes for their preparation thereof
PCT/MY2011/000175 WO2012099452A1 (en) 2011-01-21 2011-07-22 Curcumin compounds with superior structural stability and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI2011000320 MY153032A (en) 2011-01-21 2011-01-21 Curcumin compounds with superior structural stability and processes for their preparation thereof

Publications (1)

Publication Number Publication Date
MY153032A true MY153032A (en) 2014-12-31

Family

ID=46515923

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2011000320 MY153032A (en) 2011-01-21 2011-01-21 Curcumin compounds with superior structural stability and processes for their preparation thereof

Country Status (2)

Country Link
MY (1) MY153032A (en)
WO (1) WO2012099452A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107840851A (en) * 2017-12-21 2018-03-27 扬州大学 Indoles spiral shell pyrrole alloxazine compounds and its synthetic method

Also Published As

Publication number Publication date
WO2012099452A1 (en) 2012-07-26

Similar Documents

Publication Publication Date Title
MY160077A (en) Curcumin compounds and their preparations thereof
NZ705827A (en) Method of synthesizing thyroid hormone analogs and polymorphs thereof
WO2016065209A3 (en) Process for the preparation of (r,s)-nicotine
WO2015134317A8 (en) Chromatographic materials for the separation of unsaturated molecules
MX2011011797A (en) Substituted phenyllureas and phenylamides as vanilloid receptor ligands.
WO2012118812A3 (en) Substituted 6,5-fused bicyclic heteroaryl compounds
WO2009005677A3 (en) Antiviral compounds
WO2009005676A3 (en) Antiviral compounds
WO2011081277A3 (en) Saturated n-heterocyclic carbene-ligand metal complex derivatives, preparing method thereof, and preparing method of silane compound by hydrosilylation reaction using the same as catalyst
MX2011008946A (en) Agomelatine hydrohalide complex and preparation method thereof.
MX2012002997A (en) Ether derivatives of bicyclic heteroaryls.
WO2009104021A3 (en) Novel polymorphs and processes for their preparation
MX2018014130A (en) Process and intermediates for the 6,7-alpha-epoxidation of steroid 4,6-dienes.
Lachia et al. Asymmetric synthesis of the four stereoisomers of 5-deoxystrigol
WO2012031045A3 (en) Phosphonate ester derivatives and methods of synthesis thereof
MX369473B (en) Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising same and use thereof.
WO2013059281A3 (en) Processes for the preparation of novel benzimidazole derivatives
Cabré et al. Ethylene Glycol Assisted Intermolecular Pauson–Khand Reaction
WO2012104886A3 (en) System and process for producing an oxirane
MY153032A (en) Curcumin compounds with superior structural stability and processes for their preparation thereof
AU2012264476A8 (en) Process for the preparation of paliperidone
FI4056604T3 (en) Method for producing copolymer of 1,3,7-octatriene and styrene
SA517390095B1 (en) Butadiene Telomerization Catalyst and Preparation Thereof
MY160076A (en) Curcumin compounds containing indolizine and their preparations thereof
MY153034A (en) Pyrrolothiazole containing curcumin compounds