MY144464A - Pyrazole derivatives as protien kinase modulators - Google Patents
Pyrazole derivatives as protien kinase modulatorsInfo
- Publication number
- MY144464A MY144464A MYPI20052573A MYPI20052573A MY144464A MY 144464 A MY144464 A MY 144464A MY PI20052573 A MYPI20052573 A MY PI20052573A MY PI20052573 A MYPI20052573 A MY PI20052573A MY 144464 A MY144464 A MY 144464A
- Authority
- MY
- Malaysia
- Prior art keywords
- group
- nr2r3
- carbon atoms
- compounds
- linker group
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
THE INVENTION PROVIDES COMPOUNDS OF THE FORMULA (Ι) HAVING PROTEIN KINASE B INHIBITING ACTIVITY: WHEREIN A IS A SATURATED HYDROCARBON LINKER GROUP CONTAINING FROM 1 TO 7 CARBON ATOMS, THE LINKER GROUP HAVING A MAXIMUM CHAIN LENGTH OF 5 ATOMS EXTENDING BETWEEN R¹ AND NR²R³ AND A MAXIMUM CHAIN LENGTH OF 4 ATOMS EXTENDING BETWEEN E AND NR²R³, WHEREIN ONE OF THE CARBON ATOMS IN THE LINKER GROUP MAY OPTIONALLY BE REPLACED BY AN OXYGEN OR NITROGEN ATOM; AND WHEREIN THE CARBON ATOMS OF THE LINKER GROUP A MAY OPTIONALLY BEAR ONE OR MORE SUBSTITUENTS SELECTED FROM OXO, FLUORINE AND HYDROXY, PROVIDED THAT THE HYDROXY GROUP WHEN PRESENT IS NOT LOCATED AT A CARBON ATOM A WITH RESPECT TO THE NR²R³ GROUP AND PROVIDED THAT THE OXO GROUP WHEN PRESENT IS LOCATED AT A CARBON ATOM A WITH RESPECT TO THE NR²R³ GROUP; E IS A MONOCYCLIC OR BICYCLIC CARBOCYCLIC OR HETEROCYCLIC GROUP; R1 IS AN ARYL OR HETEROARYL GROUP; AND R², R³, R⁴ AND R⁵ ARE AS DEFINED IN THE CLAIMS. ALSO PROVIDED ARE PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS, METHODS FOR PREPARING THE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57784304P | 2004-06-08 | 2004-06-08 | |
| PCT/GB2004/005464 WO2005061463A1 (en) | 2003-12-23 | 2004-12-23 | Pyrazole derivatives as protein kinase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY144464A true MY144464A (en) | 2011-09-30 |
Family
ID=36940507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI20052573A MY144464A (en) | 2004-06-08 | 2005-06-07 | Pyrazole derivatives as protien kinase modulators |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR049437A1 (en) |
| MY (1) | MY144464A (en) |
| SA (1) | SA05260179B1 (en) |
| TW (1) | TWI363622B (en) |
-
2005
- 2005-06-07 MY MYPI20052573A patent/MY144464A/en unknown
- 2005-06-08 TW TW094118996A patent/TWI363622B/en not_active IP Right Cessation
- 2005-06-08 AR ARP050102341A patent/AR049437A1/en not_active Application Discontinuation
- 2005-06-22 SA SA5260179A patent/SA05260179B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SA05260179B1 (en) | 2009-06-14 |
| TW200602046A (en) | 2006-01-16 |
| AR049437A1 (en) | 2006-08-02 |
| TWI363622B (en) | 2012-05-11 |
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