MY140692A - Benzothiazole derivatives - Google Patents

Abstract

THE INVENTION RELATES TO COMPOUNDS OF THE GENERAL FORMULA WHEREIN R¹IS 1,4-DIOXEPANYL OR TETRAHYDROPYRAN-4-YL; R²IS- N(R)-(CH₂) n-5-OR 6 MEMBERED NON AROMATIC HETEROCYCLE, OPTIONALLY SUBSTITUTED BY ONE OR MORE SUBSTITUENTS, SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL OR-NR₂, OR IS -(CH2)N-5-OR 6 MEMBERED NON AROMATIC HETEROCYCLE, OPTIONALLY SUBSTITUTED BY-(CH₂)n-OH, LOWER ALKYL, LOWER ALKOXY,OR IS-(CH₂)n-5-OR 6 MEMBERED AROMATIC HETEROCYCLE, OPTIONALLY SUBSTITUTED BY LOWER ALKYL, LOWER ALKOXY, HALOGEN, HALOGEN-LOWER ALKYL, -CH₂N(R) (CH₂)2OCH3, IS (CH2)N-CYCLOALKYL, OPTIONALLY SUBSTITUTED BY HYDROXY, OR IS PHENYL, OPTIONALLY SUBSTITYTED BY LOWER ALKOXY, HALOGEN, HALOGEN-LOWER ALKYL,LOWER ALKYL, -CH2-PYRROLIDIN-1-YL,-CH2-MORPHOLINYL, -CH2N(R)(CH2)2OCH3OR-CH2-N(R)C(O)-LOWER ALKYL, OR IS 1,4-DIOXA-8-AZA-SPIRO[4,5]DECANE,OR IS 2-OXA-5-AZA-BICYCLO[2.2.1]HEPTANE, OR IS 1-OXA-8-AZA-SPIRO[4,5]DECANE,OR IS-N(R)-7-OXA-BICYCLO[2.2.1]HEPT-2-YL,OR IS 2-AZA-BICYCLO[2.2.2]DECANE; RIS HYDROGEN OR LOWER ALKYL; n IS 0 OR 1;AND AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF FOR THE TREATMENT OF DISEASES, WHICH RELATE TO THE A2A RECEPTOR.