MY132049A - Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
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Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
DISCLOSED ARE COMPOUNDS OF THE FORMULA :(FORMULA I)WHEREIN R1 REPRESENTS OPTIONALLY SUBSTITUTED ARYL, HETEROARYL, ARYLALKYL, OR CYCLOALKYL GROUPS; X, Z, AND Y ARE OPTIONALLY SUBSTITUTED NITROGEN OR CARBON ATOMS; R3 AND R4 ARE INORGANIC SUBSTITUTENTS WHICH MAY TOGETHER FORM RING STRUCTURES; M IS ZERO, ONE OR TWO; AND R5 AND R6 ARE ARE ORGANIC OR INORGANIC SUBSTITUENTS; AND THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS THEREOF, WHICH COMPOUNDS ARE HIGHLY SELECTIVE PARTIAL AGONISTS OR ANTAGONISTS AT BRAIN DOPAMINE RECEPTOR SUBTYPES OR PRODRUGS THEREOF AND ARE USEFUL IN THE DIAGNOSIS AND TREATMENT OF EFFECTIVE DISORDES SUCH AS SCHIZOPHRENIA AND DEPRESSION AS WELL AS CERTAIN MOVEMENT DISORDES SUCH AS PARKINSONISM.
MYPI95035921994-11-231995-11-23Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
MY132049A
(en)
Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands.
Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands