MY129626A - Preparations that potentiate immunogenicity in low immunogenic antigens - Google Patents

Abstract

THIS INVENTION DISCLOSES MEANS FOR OBTAINING IMMUNOGENIC PEPTIDES, POLYPEPTIDES, PROTEINS, AND THEIR CORRESPONDING NUCLEIC ACID SEQUENCES, TARGET CELLS WITH VACCINE INTEREST , OR LYSATES THEREOF, WITHOUT MAKING STRUCTURAL CHANGES IN SAID ANTIGENS, THROUGH THEIR ASSOCIATION WITH VERY SMALL SIZE PROTEOLIPOSEMES.THE OBJECT OF THE INVENTION IS TO PROVIDE IMMUNOGENIC COMPOSITIONS CONTAINING PEPTIDES, POLYPEPTIDES, PROTEINS, THEIR CORRESPONDING DNA SEQUENCES, CELLS OR THEIR LYSATES AND VERY SMALL SIZE PROTEOLIPOSOMES (VSSP), WHICH ARE FORMED BY BINDING THE OUTER MEMBRANE PROTEIN COMPLEX (OMPC) OF NEISSERIA MENINGITIDIS WITH GANGLIOSIDES, BY MEANS OF HYDROPHOBIC LINK. ADDITIONALLY, IT IS STATED THAT COMPOSITIONS CAN BE FORMULATED ALONE OR IN THE FORM OF EMULSIONS WITH THE INCOMPLETE FREUND'S ADJUVANT (IFA), AND MAY ALSO BE IYOPHILIZED.THE ESSENCE OF THE INVENTION CONSISTS IN DESCRIBING COMPOSITIONS THAT TRIGGERS IMMUNOGENICIY IN LOW IMMUNOGENIC ANTIGENS, SUCH AS GROWTH FACTOR RECEPTORS, WITHOUT IMPARTING STRUCTURAL CHANGES THEREIN. PARTICULARLY, THIS INVENTION REFERS TO PREPARATION OF IMMUNO-STIMULATING COMPOSITIONS CAPABLE OF GENERATING ANTIGEN-SPECIFIC RESPONSES, EVEN IN IMMUNO-COMPROMISED HOST, SUCH AS THOSE SUFFERING FORM CANCER OR VIRAL OR BACTERIAL CHRONIC INFECTIONS. IN SAID PETIENTS, THE ADMINISTRATION OF THE VACCINE COMPOSITIONS DESCRIBED IN THIS INVENTION HAS LEAD TO THE REESTABLISHMENT OF THE FUNCTIONALITY OF THE IMMUNE SYSTEM.VACCINE COMPOSITIONS OF THIS INVENTION CAN BE USED TO PROTECT OR TREAT INFECTIONS, OR AUTO-IMMUNE DISEASES.