MY128093A - Synthesis of ruthenium or osmium metathesis catalysts - Google Patents

Abstract

THE PRESENT INVENTION RELATES TO THE SYNTHESIS OF HIGHLY ACTIVE RUTHENIUM AND OSMIUM CARBENE METATHESIS CATALYST IN GOOD YIELD FROM READILY AVAILABLE STARTING MATERIALS. THE CATALYSTS THAT MAY BE SYNTHESIZED ARE OF THE GENERAL FORMULA M IS RUTHENIUM OR OSMIUM;X AND X¹ ARE INDEPENDENTLY ANY ANIONIC LIGAND;L AND L¹ ARE ANY NEUTRAL ELECTRON DONOR LIGAND; AND,R AND R¹ ARE EACH HYDROGEN OR ONE OF THE FOLLOWING SUBSTITUENT GROUPS: C₂-C20 ALKENYL, C₂-C20 ALKYNYL, C₁-C20 ALKYL, ARYL, C₁-C20 CARBOXYLATE, C₁-C20 ALKOXY, C₁-C20 ALKENYLOXY, C₂-C20 ALKYNYLOXY, ARYLOXY, C₂-C20 ALKOXYCARBONYL, C₁-C20 ALKYLTHIO, C₁-C20 ALKYLSULFONYL AND C₁-C20 ALKYLSULFINYL. OPTIONALLY, THE SUBSTITUENT GROUP MAY BE SUBSTITUTED WITH ONE OR MORE GROUPS SELECTED FROM C₁-C5 ALKYL, HALOGEN, C₁-C5 ALKOXY, AND ARYL. WHEN THE SUBSTITUTE ARYL GROUP IS PHENYL, IT MAY BE FURTHER SUBSTITUTED WITH ONE OR MORE GROUPS SELECTED FROM A HALOGEN, A C₁-C5 ALKYL, OR A C₁-C5 ALKOXY. SPECIFIC SYNTHETIC PROTOCOLS FOR VINYL ALKYLIDENE CATALYSTS WHEREIN R IS HYDROGEN AND R¹ IS -CHCR¹²R¹³ AND NON-VINYL ALKYLIDENE CATALYSTS ARE ALSO DISCLOSED. IN ADDITION TO THE EASE OF SYNTHESIS (TYPICALLY A ONE-STEP SYNTHESIS), THE REACTIONS GENERALLY MAY BE RUN AT OR ABOVE ROOM TEMPERATURE AND THE RESULTING PRODUCTS USUALLY MAY BE USED WITHOUT EXTENSIVE POST SYNTHESIS PURIFICATION.