MY122142A - Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8- diazabicyclo[4.3.0] nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3- quinolinecarboxylic acids and their derivatives - Google Patents

Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8- diazabicyclo[4.3.0] nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3- quinolinecarboxylic acids and their derivatives

Info

Publication number
MY122142A
MY122142A MYPI97000645A MYPI9700645A MY122142A MY 122142 A MY122142 A MY 122142A MY PI97000645 A MYPI97000645 A MY PI97000645A MY PI9700645 A MYPI9700645 A MY PI9700645A MY 122142 A MY122142 A MY 122142A
Authority
MY
Malaysia
Prior art keywords
oxo
methyl
optionally substituted
alkyl
nonan
Prior art date
Application number
MYPI97000645A
Inventor
Stefan Dr Bartel
Hans-Peter Dr Stupp
Heinz-Georg Dr Wetzstein
Thomas Dr Jaetsch
Thomas Dr Himmler
Hans-Georg Dr Rast
Werner Dr Hallenbach
Ernst Dr Heinen
Franz Dr Pirro
Martin Dr Scheer
Michael Dr Stegemann
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of MY122142A publication Critical patent/MY122142A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

THE PRESENT INVENTION RELATES TO NOVEL OPTIONALLY SUBSTITUTED 8-CYANO-L-CYCLOPROPYL-7-(2,8- DIAZABICYCLO[4.3.0]NONAN-8-YL)-6-FLUORO-L,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDS AND THEIR DERIVATIVES, OF THE GENERAL FORMULA (I) IN WHICH R1 REPRESENTS HYDROGEN, C1-C4-ALKYL WHICH IS OPTIONALLY SUBSTITUTED BY HYDROXYL, METHOXY, AMINO, METHYLAMINO OR DIMETHYLAMINO, OR (5-METHYL-2-OXO-L,3-DIOXOL-4-YL)METHYL, R2 REPRESENTS HYDROGEN, BENZYL, C1-C3-ALKYL, (5-METHYL-2-OXO-L,3-DIOXOL-4-YL)-METHYL, RADICALS HAVING THE STRUCTURES -CH=CH-COOR3, -CH2CH2COOR3, -CH2CH2CN, -CH2CH2COCH3 OR -CH2COCH3, IN WHICH R3 REPRESENTS METHYL OR ETHYL, OR A RADICAL OF THE GENERAL STRUCTURE R4-(NH-CHR5-CO)N-, IN WHICH R4 REPRESENTS HYDROGEN, C1-C3-ALKYL OR THE RADICAL -COOTERT- BUTYL, R5 REPRESENTS HYDROGEN, C1-C4-ALKYL, HYDROXYALKYL, AMINOALKYL, THIOALKYL, CARBOXYALKYL OR BENZYL AND N IS 1 OR 2, AND Y IS OXYGEN OR SULFUR, THE PROCESS FOR THEIR PREPARATION AND THEIR USE IN ANTIBACTERIAL COMPOSITIONS,
MYPI97000645A 1996-02-23 1997-02-20 Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8- diazabicyclo[4.3.0] nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3- quinolinecarboxylic acids and their derivatives MY122142A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19606762 1996-02-23
DE19633805A DE19633805A1 (en) 1996-02-23 1996-08-22 Optionally substituted 8-cyano-l-cyclopropyl-7- (2,8-diazabicyclo- [4.3.0] -nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives

Publications (1)

Publication Number Publication Date
MY122142A true MY122142A (en) 2006-03-31

Family

ID=7786206

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI97000645A MY122142A (en) 1996-02-23 1997-02-20 Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8- diazabicyclo[4.3.0] nonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3- quinolinecarboxylic acids and their derivatives

Country Status (9)

Country Link
EP (1) EP1215202A1 (en)
KR (1) KR100493576B1 (en)
AR (1) AR005958A1 (en)
DE (1) DE19633805A1 (en)
FR (1) FR11C0047I2 (en)
HU (1) HUS1200019I1 (en)
MY (1) MY122142A (en)
UA (1) UA54415C2 (en)
ZA (1) ZA971507B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19854357A1 (en) * 1998-11-25 2000-05-31 Bayer Ag Semi-hydrochloride of 8-cyano-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo / 4.3.0 / -nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo -3-quinoline carboxylic acid
DE19854355A1 (en) * 1998-11-25 2000-05-31 Bayer Ag Crystal modification B of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo- / 4.3.O / nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-quinoline carboxylic acid
DE19854356A1 (en) * 1998-11-25 2000-05-31 Bayer Ag Crystal modification A of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicyclo- / 4.3.0 / nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-quinoline carboxylic acid
DE19908449A1 (en) * 1999-02-26 2000-08-31 Bayer Ag Crystal modification C of 8-cyan-1-cyclopropyl-7- (1S, 6S-2,8-diazabicylo- [4.3.0] nonan-8-yl) -6-fluoro-1,4-dihydro-4-oxo 3-chino / incarboxylic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499992A (en) * 1983-04-18 1985-02-19 Pixall Corporation Self-cleaning support roller for an endless conveyor belt
DE3702393A1 (en) * 1987-01-28 1988-08-11 Bayer Ag 8-CYANO-1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO- 3-CHINOLINE CARBONIC ACIDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL AGENTS CONTAINING THEM
DE3910663A1 (en) * 1989-04-03 1990-10-04 Bayer Ag 5-ALKYLCHINOLON CARBONIC ACIDS
DE4019023A1 (en) * 1990-06-14 1991-12-19 Bayer Ag METHOD FOR PRODUCING CHINOLINE CARBONIC ACIDS
DE19652239A1 (en) * 1996-12-16 1998-06-18 Bayer Ag Use of 7- (2-oxa-5,8-diazabicyclo [4.3.0] non-8-yl) -quinolone and naphthyridonecarboxylic acid derivatives for the therapy of Helicobacter pylori infections and the associated gastroduodenal diseases
DE19652219A1 (en) * 1996-12-16 1998-06-18 Bayer Ag Use of 7- (1-aminomethyl-2-oxa-7-azabicyclo [3.3.0] oct-7-yl) quinolone and naphthyridonecarboxylic acid derivatives for the therapy of Helicobacter pylori infections and the associated gastroduodenal diseases

Also Published As

Publication number Publication date
KR19990082537A (en) 1999-11-25
AR005958A1 (en) 1999-07-21
UA54415C2 (en) 2003-03-17
HUS1200019I1 (en) 2016-02-29
FR11C0047I1 (en) 2011-11-11
FR11C0047I2 (en) 2013-01-11
DE19633805A1 (en) 1997-08-28
EP1215202A1 (en) 2002-06-19
ZA971507B (en) 1997-09-16
KR100493576B1 (en) 2005-09-14

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