MY121795A - Synthesis of intermediates useful in preparing tricyclic compounds - Google Patents

Synthesis of intermediates useful in preparing tricyclic compounds

Info

Publication number
MY121795A
MY121795A MYPI99005048A MYPI9905048A MY121795A MY 121795 A MY121795 A MY 121795A MY PI99005048 A MYPI99005048 A MY PI99005048A MY PI9905048 A MYPI9905048 A MY PI9905048A MY 121795 A MY121795 A MY 121795A
Authority
MY
Malaysia
Prior art keywords
formula
compound
preparing
heteroaryl
alkoxy
Prior art date
Application number
MYPI99005048A
Inventor
Charles F Bernard
Casey Michael
Chen Frank Xing
Denise C Grogan
Poirier Marc
Robert P Williams
Wong Yee-Shing
George G Wu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MY121795A publication Critical patent/MY121795A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

DISCLOSED IS A PROCESS FOR PREPARING A COMPOUND HAVING THE FORMULA: FORMULA I WHEREIN R, R1, R2, R3, AND R4 ARE INDEPENDENTLY SELECTED FROM THE GROUPCONSISTING OF H, BR, C1, F, ALKYL, OR ALKOXY, BY(A) REACTING A COMPOUND HAVING THE FORMULA FORMULA II WHEREIN RA, RB, RC, RD, AND RE ARE INDEPENDENTLY SELECTED FROM THE GROUPCONSISTING OF H, HALO, ALKYL, OR ALKOXY, AND R5 IS ARYL OR HETEROARYL, WITH A DEHYDRATING AGENT TO PRODUCE AN IMINE HAVING THE FORMULA: FORMULA (B) HYDROLYZING THE IMINE PRODUCED IN STEP (A) TO PRODUCE THE COMPOUND HAVING FORMULA (I). ALSO DISCLOSED ARE NOVEL INTERMEDIATES HAVING THE FORMULA : FORMULA WHEREIN RA, RB, RC, RD, AND RE ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTINGOF H, HALO, ALKYL, OR ALKOXY, AND R5 IS ARYL OR HETEROARYL. ALSO DISCLOSED IS A PROCESSFOR PREPARING A COMPOUND HAVING THE FORMULA: FORMULA III COMPRISING: REACTING A COMPOUND HAVING THE FORMULA FORMULA IV WITH NH2R5 IN THE PRESENCE OF A PALLADIUM CATALYST, CARBON MONOXIDE, A BASE, AND ANETHER SELECTED FROM THE GROUP CONSISTING OF; CH3OCH2CH2OCH3;CH3OCH2CH2OCH2CH2OCH3; AND CH3OCH2CH2OCH2CH2OCH2CH2OCH3, WHEREIN X IS H, BR, C1, OR F, AND R5 IS ARYL OR HETEROARYL. THE COMPOUNDS MADE BY THESEP ROCESSES ARE USEFUL INTERMEDIATES FOR PREPARING COMPOUNDS THAT ARE ANTIHISTAMINES ORINHIBITORS OF FARNESYL PROTEIN TRANSFERASE.
MYPI99005048A 1998-11-20 1999-11-19 Synthesis of intermediates useful in preparing tricyclic compounds MY121795A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19700398A 1998-11-20 1998-11-20

Publications (1)

Publication Number Publication Date
MY121795A true MY121795A (en) 2006-02-28

Family

ID=22727622

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI99005048A MY121795A (en) 1998-11-20 1999-11-19 Synthesis of intermediates useful in preparing tricyclic compounds

Country Status (13)

Country Link
EP (1) EP1131296A2 (en)
JP (2) JP4663122B2 (en)
CN (1) CN1162404C (en)
AR (1) AR028138A1 (en)
AU (1) AU3790200A (en)
CA (1) CA2351693C (en)
CO (1) CO5150169A1 (en)
HK (1) HK1038698A1 (en)
MY (1) MY121795A (en)
PE (1) PE20001243A1 (en)
TW (1) TW509680B (en)
WO (1) WO2000030589A2 (en)
ZA (1) ZA200103246B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1274688B1 (en) * 2000-04-18 2006-12-20 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
WO2004058719A1 (en) * 2002-12-26 2004-07-15 Cadila Healthcare Limited A process for preparing benzocyclohetapyridin-11-ones
CN108218773A (en) * 2018-02-28 2018-06-29 朱路英 A kind of method for preparing resisting allergic rhinitis drug loratadine intermedite

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
EP0208855B1 (en) * 1985-05-13 1991-03-06 Schering Corporation process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
US5089496A (en) 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
CA2245055C (en) * 1989-02-28 2003-03-25 F. Hoffmann-La Roche Ag Amidation of pyridines
US5672750A (en) * 1994-12-16 1997-09-30 Eastman Chemical Company Preparation of aromatic amides from carbon monoxide, an amine and an aromatic chloride
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them
DK1019392T3 (en) 1995-12-22 2006-03-20 Schering Corp Tricyclic amides useful for inhibiting G protein function and for treating proliferative diseases
ES2143816T3 (en) * 1996-05-09 2000-05-16 Lonza Ag PROCEDURE FOR THE PREPARATION OF ARYLAMIDES FROM HETEROAROMATIC CARBOXYL ACIDS.
US5958890A (en) * 1996-09-13 1999-09-28 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
DE69819316T2 (en) * 1997-03-25 2004-07-22 Schering Corp. SYNTHESIS OF INTERMEDIATE PRODUCTS APPLICABLE IN THE PRODUCTION OF TRICYCLIC COMPOUNDS

Also Published As

Publication number Publication date
JP2010132701A (en) 2010-06-17
JP2002530307A (en) 2002-09-17
CO5150169A1 (en) 2002-04-29
AU3790200A (en) 2000-06-13
TW509680B (en) 2002-11-11
JP4663122B2 (en) 2011-03-30
CA2351693A1 (en) 2000-06-02
CN1162404C (en) 2004-08-18
WO2000030589A3 (en) 2001-01-04
EP1131296A2 (en) 2001-09-12
HK1038698A1 (en) 2002-03-28
AR028138A1 (en) 2003-04-30
ZA200103246B (en) 2002-07-22
WO2000030589A2 (en) 2000-06-02
PE20001243A1 (en) 2000-11-15
CN1326444A (en) 2001-12-12
CA2351693C (en) 2009-01-20

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