MY106731A - Novel antigens and methods therefor - Google Patents

Novel antigens and methods therefor

Info

Publication number
MY106731A
MY106731A MYPI90001227A MYPI19901227A MY106731A MY 106731 A MY106731 A MY 106731A MY PI90001227 A MYPI90001227 A MY PI90001227A MY PI19901227 A MYPI19901227 A MY PI19901227A MY 106731 A MY106731 A MY 106731A
Authority
MY
Malaysia
Prior art keywords
protein
particle
hepatitis
residues
followed
Prior art date
Application number
MYPI90001227A
Inventor
Voet Pierre
J Merckelbach Armin
P Hollenberg Cornelis
Jacobs Eric
Harford Nigel
Cabezon Teresa
Rutgers Apolonia
A Hollenberg Zbigniew
Comberbach Martin
Original Assignee
Smithkline Biologicals S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Biologicals S A filed Critical Smithkline Biologicals S A
Publication of MY106731A publication Critical patent/MY106731A/en

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A COMPOSITE PARTICLE COMPRISING AT LEAST TWO POLYPEPTIDES CORRESPONDING TO ALL OR PART OF A PROTEIN HAVING THE BIOLOGICAL ACTIVITY OF ONE OF THE HEPATITIS B SURFACE ANTIGENS, WHEREIN THE PARTICLE PRESENTS AT LEAST TWO ANTIGENIC DETERMINANTS PROVIDED BY THE S-PROTEIN, PRES2-PROTEIN OR PRES1-PROTEIN, SAID PARTICLE OPTIONALLY FURTHER COMPRISING HOST SPECIFIC LIPIDS. THE INVENTION ALSO PROVIDES A MODIFIED HEPATITIS B SURFACE ANTIGEN L PROTEIN WHICH MAY BE USED ALONE OR INCORPORATED INTO SUCH COMPOSITE PARTICLES. A PARTICULAR EMBODIMENT OF THE MODIFIED L PROTEIN (L*) COMPRISES RESIDUES 12-52 FOLLOWED BY RESIDUES 133-145 FOLLOWED BY RESIDUES 175-400 OF THE L PROTEIN AND A PARTICULAR EMBODIMENT OF A COMPOSITE PARTICLE HAS THE FORM (L*, S) WHERE S IS THE S-PROTEIN OF HBsAG.IMPROVED HEPATITIS B VACCINES MAY BE PREPARED FOLLOWING EXPRESSION OF THE ABOVE IMMUNOGENS, ESPECIALLY IN YEASTS SUCH AS S. CEREVISIAE AND HANSENULA POLYMORPHA.
MYPI90001227A 1989-08-03 1990-07-24 Novel antigens and methods therefor MY106731A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38918489A 1989-08-03 1989-08-03
US38534291A 1991-01-09 1991-01-09

Publications (1)

Publication Number Publication Date
MY106731A true MY106731A (en) 1995-07-31

Family

ID=79554130

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI90001227A MY106731A (en) 1989-08-03 1990-07-24 Novel antigens and methods therefor

Country Status (1)

Country Link
MY (1) MY106731A (en)

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