MY106724A - Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof. - Google Patents

Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof.

Info

Publication number
MY106724A
MY106724A MYPI90001138A MYPI19901138A MY106724A MY 106724 A MY106724 A MY 106724A MY PI90001138 A MYPI90001138 A MY PI90001138A MY PI19901138 A MYPI19901138 A MY PI19901138A MY 106724 A MY106724 A MY 106724A
Authority
MY
Malaysia
Prior art keywords
taxol
derivatives
pharmaceutical compositions
preparation
methods
Prior art date
Application number
MYPI90001138A
Inventor
J Stella Valentino
E Mathew Abraham
Original Assignee
Univ Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kansas filed Critical Univ Kansas
Priority to MYPI90001138A priority Critical patent/MY106724A/en
Publication of MY106724A publication Critical patent/MY106724A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

DERIVATIVES OF TAXOL REPRESENTED BY THE FORMULA WHEREIN R AND R'' ARE EACH H OR THE RESIDUE OF AN AMINO ACID SELECTED FROM THE GROUP CONSISTING OF ALANINE, LEUCINE, ISOLEUCINE, SALINE,PHENYLALANINE, PROLINE, IYSINE AND ARGININE OR A GROUP OF THE FORMULA WHEREIN N IS AN INTEGER OF 1 TO 3 AND R2 AND R3 ARE EACH HYDROGEN ON AN ALKYL RADICAL HAVING FROM ONE TO THREE CARBON ATOMS OR WHEREIN R2 AND R3 TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A SATURATED HETEROCYCLIC RING HAVING FOUR TO FIVE CARBON ATOMS, WITH THE PROVISO THAT AT LEAST ONE OF R AND R1 IS NOT HYDROGEN, ARE PROVIDED TOGETHER WITH PHARMACEUTICAL COMPOSITIONS OF SUCH DERIVATIVES. THE TAXOL DERIVATIVES HAVE INCREASED WATER SOLUBILITY AS COMPARED TO TAXOL, AND HAVE EXCELLENT ANTITUMOR ACTIVITY.
MYPI90001138A 1990-07-07 1990-07-07 Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof. MY106724A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MYPI90001138A MY106724A (en) 1990-07-07 1990-07-07 Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI90001138A MY106724A (en) 1990-07-07 1990-07-07 Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof.

Publications (1)

Publication Number Publication Date
MY106724A true MY106724A (en) 1995-07-31

Family

ID=79554081

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI90001138A MY106724A (en) 1990-07-07 1990-07-07 Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof.

Country Status (1)

Country Link
MY (1) MY106724A (en)

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