MY103598A - Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells. - Google Patents

Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells.

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Publication number
MY103598A
MY103598A MYPI88000881A MYPI19880881A MY103598A MY 103598 A MY103598 A MY 103598A MY PI88000881 A MYPI88000881 A MY PI88000881A MY PI19880881 A MYPI19880881 A MY PI19880881A MY 103598 A MY103598 A MY 103598A
Authority
MY
Malaysia
Prior art keywords
enzyme
antibody
tumor cells
tumor
prodrug
Prior art date
Application number
MYPI88000881A
Inventor
G Saulnier Mark
P Brown Joseph
E Kerr David
D Senter Peter
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/211,301 external-priority patent/US4975278A/en
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MY103598A publication Critical patent/MY103598A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

THIS INVENTION RELATES TO A NOVEL METHOD FOR THE DELIVERY OF CYTOTOXIC DRUGS TO TUMOR CELLS BY THE ADMINISTRATION OF A TUMOR-SPECIFIC ANTIBODY-ENZYME CONJUGATE THAT BINDS TO THE TUMOR CESSL, AND THE ADDITIONAL ADMINISTRATION OF A PRODRUG THAT IS CONVERTED AT THE TUMOR SITE, IN THE PRESENCE OF THE ANTIBODY-BOUND ENZYME, TO AN ACTIVE CYCTOTOXIC DRUG. ACCORDING TO PREFERRED EMBODIMENTS OF THIS INVENTION, ANTIBODY-ANZYME CONJUGATES CONTAINING THE ENZYME, ALKALINE PHOSPHATASE ("AP"), HAVE BEEN USED IN CONJUCTION WITH THE NOVEL PRODRUG, ETOPOSIDE-4''-PHOSPHATE OR 7-(-22'-AMINOETHYL PHOSPHATE) MITOMYIC OR A COMBINATION THEREOF, TO EFFECT KILLING OF TUMOER CELLS. ACCORDING TO ANOTHER EMBODIMENT OF THE INVENTION, AN ANTIBODY-ENZYME CONJUGATE CONTAINING THE ENZYME, PENICILLIN V AMIDASE ("PVA"), HAS BEEN USED IN CONJUCTION WITH A NOVEL PRODRUG, N-(P-HYDROXYPHENOXYACETYL) ADRIAMYCIN TO EFFECT KILLING OF TUMOR CELLS. STILL ANOTHER EMBODIMENT OF THE INVENTION RELATES TO THE USE OF AN ANTIBODY0ENZYME CONJUGATE CONTAINING THE ENZYME, CYTOSINE DEAMINASE ("CD"), IN COMBINATION WITH THE PRODRUG, 5-FLUOROCYTOSINE, TO EFFECT KILLING OF TUMOR CELLS. THE METHODS, ANTIBODY-ENZYME CONJUGATES, PRODURGS, PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS OF THIS INVENTION PROVIDE FOR ENHANCED SELECTIVE KILLING OF TUMOR CELLS AND ARETHUS USEFUL IN THE TREATMENT OF CANCERS AND OTHER TUMORS.
MYPI88000881A 1988-06-29 1988-08-03 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells. MY103598A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/211,301 US4975278A (en) 1988-02-26 1988-06-29 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells

Publications (1)

Publication Number Publication Date
MY103598A true MY103598A (en) 1993-08-28

Family

ID=79961367

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI88000881A MY103598A (en) 1988-06-29 1988-08-03 Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells.

Country Status (1)

Country Link
MY (1) MY103598A (en)

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