MXPA99007670A - N - Google Patents

Abstract

N-Heterocyclic derivatives of formula (I) are described herein, as well as other N-Heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein

Description

N-HETEROCYCLIC DERIVATIVES NOS INHIBITORS This application is a continuation in part of the application serial number 08 / 808,975, filed on February 19, 1997, which is hereby incorporated by reference in its entirety.

FIELD OF THE INVENTION The invention relates to a series of compounds N-heterocyclics and derivatives useful as inhibitors of nitric oxide synthase (NOS), and with therapy methods for various diseases using these compounds.

BACKGROUND OF THE INVENTION Nitrogen monoxide (NO) has been linked to many different physiological processes, including smooth muscle relaxation, platelet inhibition, nerve transmission, immune regulation and penile erection. Nitric oxide is produced under various conditions in virtually all nucleated cells of mammals. Numerous pathologies have been ascribed to abnormalities in NO production that include attack, insulin dependent diabetes, hypotension induced by septic shock, rheumatoid arthritis and multiple sclerosis. Nitric oxide is synthesized in biological tissues by an enzyme called nitric oxide synthase (NOS) which uses NADPH and molecular oxygen to oxidize L-arginine to citrulline and nitric oxide. Nitric oxide synthase (NOS) exists in at least three forms, which fall into two main categories: constitutive and inducible. The two constitutive forms, which are dependent on calcium and calmodulin, have been identified, and an inducible isoform has been identified. The constitutive isoforms are: (1) a neuronal isoform, NOS-1 or nNOS, which is found in brain and skeletal muscles, and (2) an endothelial isoform, NOS-3 or eNOS, which is expressed in spleen endothelium blood, the epithelium of the bronchial tree in the brain. These constitutive isoforms are not the target of the NOS inhibitors of the present invention. The inducible isoform (NOS-2 or iNOS) is expressed virtually in all nucleated cells of mammals after exposure to inflammatory cytokines or lipopolysaccharides. Its presence in macrophages and pulmonary hepithelial cells is particularly notable. The inducible isoform is not stimulated by calcium and blocked by calmodulin antagonists. It contains several tightly bonded cofactors, which include FMN, FAD and tetrahydrobiopterin.

Nitric oxide generated by the inducible form of NOS has been implicated in the pathogenesis of inflammatory diseases. In experimental animals, impotention induced by lipopolysaccharide or tumor necrosis factor a can be reversed by NOS inhibitors. Conditions which lead to cytokine-induced hypotension include septic shock, hemodialysis, and interleukin therapy in cancer patients. The iNOS inhibitor is expected to be effective in treating cytokine-induced hypotension. In addition, recent studies have suggested a role for NO in the pathogenesis of inflammation and therefore inhibitors of NOS would have beneficial effects on inflammatory bowel disease, cerebral ischemia and arthritis. NOS inhibitors may also be useful in treating adult respiratory distress syndrome (ARDS) and myocarditis, and may be useful as adjuvants in short-term immunosuppression in transplant therapy. The diversity and ubiquity of the NO function in physiology makes its specific therapeutic objective of the phenomena related to NO an important consideration. Since the production of endogenous NO is the result of the actions of related but different isozymes, the differential inhibition of NOS isozymes allows a more selective therapy with fewer side effects.

BRIEF DESCRIPTION OF THE INVENTION In one aspect, the invention is directed to compounds of formula (I), formula (II) and formula (III): wherein: A is -R1, -OR1, -C (0) N (R1) R2, -P (0) [N (R1) R2] 2, -NfR ^ CfOlR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -S .O. IR1, -S02NHC (0) R1, -NHS02R2 :, -SO? J.R H, -C (0) NHS02R22, and -CH = N0R1; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, 0 or C (R) H; each is N or CH; Q is chosen from the group consisting of a direct link, -C (0) -, -0-, -CXN-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -NYR ^ CfOjNÍR ^ R16, -SFOXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -NYR ^ UOJR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -SÍOA-R1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R 1 and R 2 are independently selected from the group consisting of hydrogen, C 1 C alkyl ,. optionally substituted, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C2-C6 alkenyl] -R9, - [C2-C6 alkynyl] -R9, - [C2-C6 alkyl] -R10 ( optionally substituted by hydroxy), - [C-C8] -R1: L (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [Ci-C alkyl] -N (R1) R2, - [C_-C8 alkyl] -N (R7R2, - [Ci-CJ-R6 alkyl, - [C2-C8 alkyl] -R10, - [Ci-Cgj-R11 alkyl, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl), or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q -R3 taken together, represent -C (0) OH, -C (0) N (R ^ R2, -C (= NH) -N (RX) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -NYRXCtOJN R ^ R16, - N (R16) C (0) OR16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (0) OR16, - [C0-C8 alkyl] -C (H) [ C (0) OR16] 2 and - [C.sub.C.sub.2 -C.sub.C. R 6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C 1 -C 8 alkyl, - [C 2 -C 8 alkyl] -R 10, - [C 7 -C .. alkyl- R 11, acyl, - C (0) R8, -C (O) ~ [Ci-Cgj-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl , monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0) -R3-N (R1) C (0) -R23-N (R1) R2, -C (0) -N (R1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; - each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N0: or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. In another aspect, the invention is directed to compounds of formula (IV): where: AA is an amino acid; X, Y and Z are independently N or C (R19); U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; W is N or CH; R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C_-C20 alkyl, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, - [C2-C8 alkenyl] -R9, - [alkynyl] of C2-C8] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [Ci-Cgj-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is an optionally substituted N-heterocyclyl; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -NR ^ .CONR ^ R16 , -N (R16) C (0) OR16, -N (R16) C (0) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C8 alkyl] -C (H) ) [C (0) OR16] 2 and - [C0-C8 alkyl] -C (O) N (R1) R16; each R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R19 is hydrogen, alkyl (optionally substituted by hydroxy), cyclopropyl, halo or haloalkyl; each R21 is hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and t is zero, 1 or 2; as a single isomer or mixture thereof, or a pharmaceutically acceptable salt thereof. In another aspect, the invention is directed to compounds of formula (Va), formula (Vb) or formula (Ve): wherein B is a 5 or 6 membered carbocyclyl or heterocyclyl, optionally substituted; and wherein: A is -R1, -OR1, -C (O) N (R1) R2, -P (O) [N (R1) R2] ,, -NR ^ COR2, -N (R16) C (0) OR2, -NR ^ R21, -N (R16) C (O) N (R1) R16, -SOiR1, -C (O) NHS02R22, and - CH = NOR1; each of X, Y and Z are independently N or C (R19); V is N (R4), S, O or C (R4) H; each is N or CH; Q is chosen from the group consisting of a direct link, -C (0) -. -0-, -C (= N-R:) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R15) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R15, -S (0) tRx (when t is zero) or -NHSO, R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -NfR ^ R21, -N (R16) C (0) N ( R1) R16, -S (0) tRx (when t is zero) or -NHSO: R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, [C2-C8 alkenyl] -R9, - [alkynyl] of C2-C8] -R9, - [C: -C8 alkyl] -R10 (optionally substituted by hydroxy), - [C1-C6] -R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [Ci-C alkyl,] -C (O) N (R1) R2, - [C_-CB alkyl] -NYR ^ R2, - [alkyl of C.-Cu.-R8, - [C2-C8 alkyl] -R10, - [Ci-Cgj-R11 alkyl, and heterocyclyl (optionally substituted by 1 or more substituents which are selected from group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C (0) N (R1) R2, -C (= NH) -N (R1) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; Rd is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C 1 -C 8 alkyl, - [C 2 -C 8 alkyl] -R 10, - [C 1 -C 10 alkyl, acyl, -C ( 0) R8, -C (O) - [XC ..- R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2 , -C (0) -R23-N (R1) C (0) -R23-N (RX) R2, -C (0) -NÍR1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each Ru is independently chosen from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. In another aspect, the invention is directed to a compound of formula (Vía), formula (VIb) or formula (VIc): wherein B is a 5 or 6 membered carbocyclyl or heterocyclyl, optionally substituted; and wherein: A is -R1, -OR1, -UOJNtR R2, -P (O) [N (R1) R2] 2, -NYR ^ UOJR2, -N (R16) C (0) OR2, -NfR ^ R 1, -N (R 16) C (O) N (R 1) R 16, -S (O) tR 1, -SO ^ NHUOR 1, -NHS02R22, -S02N (R 1) H, -C (O) NHS02R22, and -CH ^ NOR1; each of X, and Z are independently N or C (R19); V is N (R4), S, O or C (R4) H; each W is N or CH; Q is selected from the group consisting of a direct bond, -C (0) -, -0-, -C (= N-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -N (R:) R21, -NÍR ^ ÍÇÍOJNfR R16, -SÍOXR1 (when t is zero) or -NHS0; R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -NYR ^ UOR2, -N (R16) C (0) OR2, -N (RX) R21, -N (RlS) C (0) N (R1) R16, -YES.R1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R1 and R2 are independently chosen from the group consisting of hydrogen, C ^ C alkyl ,. optionally substituted, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C2-C6 alkenyl] -R9, - [C2-C6 alkynyl] -R9, - [C2-C6 alkyl] -R10 ( optionally substituted by hydroxy), - [C1-C2] -R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C-C8 alkyl] -N (R1) R2, - [N (RX) alkyl, - [Ci alkyl] -Cgl-R6, - [C2-C8 alkyl] -R10, - [alkyl of X-CgJ-R11, and heterocyclyl (optionally substituted by 1 or more substituents which are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -CÍOJNfR R2, -C (= NH) -N (RX) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [Cx-Cg.-R8 alkyl, - [C2-C8 alkyl] -R10, - [acyl alkyl, -C (0) R8, - C (O) - [X-CgJ-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl optionally substituted, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0 ) -R23-N (R1) C (0) -R23-N (R1) R2, -C (0) -N (R1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each Ru is independently chosen from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkylene R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. In another aspect, the invention is directed to a compound of formula (Vlla), formula (Vllb) or formula (VIIc): (Vlla); A is -R1, -OR1, -ClOJNtR1) ^, -P (O) [N (R1) R2] 2, -N (R C .O'R2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, -S .O. tR1. -SO NHCIOJR1, -NHS02R22, -S02N (R1) H, -C (O) NHSO, R22, and -CH = NOR1; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, O or C (R4) H; each is N or CH; Q is chosen from the group consisting of a direct link, -C (0) -. -0-, -C (= N-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -NR ^ R21, -N (R16) C (0) N (R1) R16, -SÍOXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R COR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -S (0) tR1 (when t is zero) or -NHS02R22, myn can not both be zero, t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C_-C2o alkyl, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C2-C8 alkenyl] -R9, - [alkynyl] of C2-C8] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [C_-C8] -Rn (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [alkyl -C (O) N (R1) R2, - [C_-C8 alkyl] -N (RX) R2, - [C 2 -C 8 alkyl] -R 10, - [C 1 -C 8 alkyl] -Ru, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl) ); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C.O.N.R R2, -C (= NH) -N (R1) R2 O R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -N (R16) C ( 0) N (R1) R16, -N (R16) C (0) OR16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0 alkyl] -C8] -C (H) [C (0) OR16] 2 and - [C.sub.-Cgl-UOJNIR R16 alkyl; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C2-C8 alkyl] -R10 alkyl, - [Ci-Cgl-R11 alkyl, acyl, -C (0) R8, -C (O) - [XC alkyl -R8, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, N optionally substituted heterocyclyl, -C (= NH) -N (CN) R1, -C (O) -R23-N (R1) R2, -C (O) -R23-N (R1) C (O) -R23 -N (R1) R2, -C (O) -N (R1) -R23-C (O) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. In another aspect, the invention is directed to a compound of formula (VIII): where two of X, Y and Z are nitrogen and the third is CH. In another aspect, the invention is directed to a compound of formula (IXa), formula (IXb) or formula (IXc): where it is a solid substrate; L is bond residue; each of X, Y and Z are independently N or C (R10); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, 0 or C (R4) H; each W is N or CH; Q is selected from the group consisting of a direct bond, -C (0) -, -0-, -C ^ N -R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -N (R2) R21, -NR ^ ÍUOJNÍR ^ R16, -SÍOXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -NYR ^ CfOJR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -SÍOXR1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R2 are independently chosen from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C2-C8 alkenyl] -R9, - [C2 alkynyl] -C8] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [C_-C8] -Ru (optionally substituted by hydroxy), optionally substituted heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [alkyl of -N (R1) R2, - [Cj-Cg alkyl] -N (RX) R2, - [alkyl of Ci-CgUR6, - [C2-C8 alkyl] -R10, - [C_-Cg alkyl] -Rn, and heterocyclyl (optionally substituted by 1 or more substituents which are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C (0) N (R1) R2, -C (= NH) -N (RX) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -NfR ^ lCfOlNlR1) ^ 6 , -N (R16) C (0) OR16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C3 alkyl] -C (H) ) [C (0) OR16] 2 and - [alkyl of Co-CgUUOJNÍR1) R16; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C1-C8 alkyl] -R8, - [C: -C8 alkyl] -R10, - [C-Cg.-R11 alkyl, acyl, -C (0) R8, -C (O) - [C-C8 alkyl] -R8 . alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, N- optionally substituted heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0) -R23-N (R1) C (0) -R23- N (R1) R2, -C (0) -N (R1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R6 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. In another aspect, the invention is directed to a pharmaceutical composition comprising a compound of formula (I), formula (II) or formula (III) as described above and a pharmaceutically acceptable carrier. In another aspect, the invention is directed to a process for the synthesis of compounds of formula (I), formula (II) or formula (III): R20) n (III); wherein: A is -R1, -OR1, -CFOINHR ^ R2, -P (O) [N (R1) R2] 2, -NfR ^ CÍOlR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, -SIOltR1, -S02NHC (0) Rx, -NHS02R22, -C (O) NHS02R22, and -CH ^ NOR1; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, or O; each W is N or CH; Q is chosen from the group consisting of a direct link, -C (O) -, -O-, -CUN-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R :) C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (Rx) Rlβ , -SÍOXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -NR ^ C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N ( R1) R16, -SÍOXR1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C2-C2o alkyl, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, [C2-C8 alkenyl] -R9, - [ C2-C8 alkynyl] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [C ^ C -R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [Ci-C alkyl] -C (O) N (R1) R2, - [CX-C8 alkyl] -N (RX) R2, - [Cx-C8 alkyl] -R8. - [C2-C8 alkyl] -R10, - [C de-Cgj-R 11 alkyl, and heterocyclyl (optionally substituted by 1 or more substituents which are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C.O.N.R1) R2 / -C (= NH) -N (RX) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -N (R ^ .CONR R16, -N (R16) C (0) OR16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C8 alkyl] -C ( H) [C (0) OR16] 2 and - [C 1 -C 8 alkyl-UOWR R 16; R 6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl of X-CgJ-R 8, - [ C2-C3] -R10, - [alkyl of X-Cg.-R11, acyl, -C (0) R8, -C (O) - [C1-C8 alkyl] -R8, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, aryl l-sulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0) -R23-N (R1) C (0 ) -R23-N (R1) R2, -C (0) -N (R2) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each Ru is independently chosen from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; comprising the sequential steps of: (a) reacting an equivalent of a compound of formula (XI): where W is N or CH; with about one equivalent of a chloro substituted compound of formula (XII): Cl X:? N: XI wherein X, Y and Z are independently N or C (R19); U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19, and with the proviso that X, Y and Z can not all be C (R19) when U is C (R5); R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -NÍR ^ UÍOJNÍR R16, - N (R16) C (0) OR16, -N (R16) C (0) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C8 alkyl] -C (H) [ C (0) OR16] 2 and - [Co-C-UJNfR ^ R16 alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; - A l eada. R19 is independently hydrogen, alkyl (optionally substituted by hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; and each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; to produce a compound of the formula (XIII): (b) reacting a compound of formula (XIII) with a compound of formula (XlVa), formula (XlVb), or formula (XIVc): where: A is -R1, -OR1, -C (0) i (R1) Rz, -P (O) [N (R1) R2] 2, -NÍR ^ CÍOÍR2, -N (R16) C (0) OR2, -N (R1) R21, -N (R16) C (O) N (R1) R16, -S (0) _Rx, -S02NHC (0) R1, -NHS02R22, -SO? J.RH, -C (O) NHSO, R22, and -CH = NOR1; V is N (R4), S, or O; Q is chosen from the group consisting of a direct link, -C (0) -. -0-, -C (= N-R1) -, -S (0), and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) CONR ^ R16, -SÍOXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R ^ C.O) R :, -N (R16) C (0) OR2, -N.R ^ R21. -N (R16) C (0) N (R1) R16, -SÍOXR1 (when t is zero) or -NHS02R22, m and n can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R1 and R2 are independently selected from the group consisting of hydrogen, X-C alkyl. optionally substituted, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C2-C6 alkenyl] -R9, - [C2-C6 alkynyl] -R9, - [C2-C6 alkyl] -R10 ( optionally substituted by hydroxy), - [X-Cgj-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C-Cg alkyl] -N (R1) R2, - [X-Cg alkyl] -NYR ^ R, - [ XC alkyl -R6, - [C2-C8 alkyl] -R10, - [Ci-Cgj-R11 alkyl, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C (0) ri (R1) R2, -C (= NH) -NtR R2 O R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C1-C8 alkyl] -R8, - [C2-C8 alkyl] -R10, - [alkyl of X-Cgj-R11, acyl, -C (0) R8, -C (O) - [X-Cg.-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1 ) R2, -C (0) -R23-N (R1) C (O) -R23-N (R1) R2, -C (O) -N (R1) -R23-C (O) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; to produce a compound of formula (I), formula (II) or formula (III). In another aspect, the invention is directed to synthesize a compound of formula (I), formula (II) or formula (III): H) q - (C (R13) H) -D4- (C (R14) R2 °) n-A (III); wherein: A is -C (0) N (Rla) R2; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, 0 or C (R4) H; each W is N or CH; Q is selected from the group consisting of a direct bond, -C (0) -, -O-, -CUN-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -NYR ^ R21, -NfR ^ lCfOlNtR'lR16, -SÍOXR1 (when t is zero) or -NHSO: R22, n, q and r can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R2) C (0) R2, -N (R16) C (0) OR2, -NYR ^ R21, -N (R16) C (0) N ( R1) R16, -SFOl.R1 (when t is zero) or -NHS02R22, m and n can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; R: a is hydrogen; each R1 and R2 are independently chosen from the group consisting of hydrogen, optionally substituted C_-C20 alkyl, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C2-C6 alkenyl] -R9, - [alkynyl] of C2-C6] -R9, - [C2-C6 alkyl] -R10 (optionally substituted by hydroxy), - [C_-C8] -Rn (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C_-C8 alkyl] -N (R1) R2, - [C_-C8 alkyl] -N (RX) R2, - [Cx-C8 alkyl] -R6, - [C2-C8 alkyl] -R10, - [alkyl of X-Cgj-R11, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -CÍOJNÍR ^ R2, -C (= NH) -N (R1) R2 O R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -N (R ^ .CON R1) R16, -N (R16) C (0) OR16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (0) OR16, - [C0-CS alkyl] - C (H) [C (0) OR16] 2 and - [alkyl of R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl of X-Cg.-R8, - [C2-C8 alkyl] -R10, - [Ci-Cgj-R11 alkyl, acyl, -C (0) R8, -C (O) - [X-Cg-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylamin ocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0) -R23-N (R1) C (0 ) -R23-N (R1) R2, -C (0) -N (RX) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S0R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; which comprises photolytically separating the compound of formula (IXa), formula (IXb) or formula (IXc): ; where U, V,, X, Y and Z are as defined in the above; R2, R3, R12, R13, R14, R15, R17 and R20 are as defined in the above; it is a solid substrate; and L is the linking residue of the formula (IX); wherein the valency not satisfied to the right of the formula represents the point of attachment to the solid substrate and the valence not satisfied to the left of the formula represents the point of attachment to the ligand; to form the compound of formula (I), formula (II) and formula (III) as defined above.

In another aspect, the invention is directed to a method for treating a condition resulting from an abnormality in the production of nitric oxide, which comprises administering to a mammal having a condition resulting from an abnormality in the production of nitric oxide, of a therapeutically effective amount of a compound of formula (I), formula (II), formula (III), formula (IV), formula (Va), formula (Vb), formula (Ve), formula (Via), formula (VIb), formula (VIc), formula (Vlla), formula (Vllb), formula (VIIc), as defined in the above.

DETAILED DESCRIPTION OF THE INVENTION Definitions As used in this specification and in the accompanying clauses, unless otherwise specified, the following terms have the meaning indicated: "Alkyl" refers to a straight or branched hydrocarbon chain radical consisting solely of carbon atoms and hydrogen, which do not contain saturations, having 1 to 8 carbon atoms, and which is attached to the rest of the molecule by a single bond, for example, methyl, ethyl, n-propyl, 1-methylethyl (isoprene), propyl), n-butyl, n-pentyl, 1,1-dimethylethyl (t-butyl), and the like. Alkyl radicals having more than 8 carbon atoms are indicated herein by the notation "[C -C alkyl]" where x and y indicate the number of carbons present. The alkyl radicals may optionally be substituted by one or more substituents which are independently selected from the group consisting of halo, hydroxy, alkoxy, carboxy, cyano, carbonyl, alkoxycarbonyl, cyano, amino, monoalkylamino, dialkylamino, nitro, alkylthio, amidino, aryl, heterocyclyl, aryloxy, aralkoxy, acylamino, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl. "Alkenyl" refers to a monovalent or divalent radical, straight or branched chain, consisting solely of carbon and hydrogen, containing at least one double bond and having from 1 to 8 carbon atoms, for example, ethenyl, prop-1-enyl, but-1-enyl, pen-1-enyl, penta-1,4-dienyl, and the like. "Alkynyl" refers to a straight or branched chain monovalent or divalent radical consisting solely of carbon and hydrogen, containing at least one triple bond and having from 1 to 8 carbon atoms, for example, ethinyl, propyl 1-butyl, but-1-ynyl, pen-1-ynyl, pent-3-ynyl and the like. "Alkoxy" refers to a radical of the formula -ORa wherein Ra is an alkyl radical as defined above, for example, methoxy, ethoxy, propoxy and the like.

"Alkoxycarbonyl" refers to a radical of the formula -C (0) ORa wherein Ra is an alkyl radical as defined above, for example methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl and the like. "Alkoxycarbonylalkyl" refers to a radical of the formula -Ra-C (0) ORa wherein each Ra is independently an alkyl radical as defined above, for example 2- (methoxycarbonyl) ethyl, 3- (ethoxycarbonyl) propyl, - (n-propoxycarbonyl) butyl and the like. "Alkylsulfonylamino" refers to a radical of the formula -N (H) S (O) 2-Ra wherein Ra is an alkyl radical as defined above, for example methylsulfonylamino, ethylsulfonylamino and the like. "Alkylsulfonyl" refers to a radical of the formula -S (0) 2-Ra wherein Ra is an alkyl radical as defined above, for example methanesulfonyl, ethylsulfonyl and the like. "Alkylthio" refers to a radical of the formula -S-Ra wherein Ra is an alkyl radical as defined above, for example methylthio, ethylthio, n-propylthio and the like. "Amidino" refers to a radical of the formula -C (NH) -NH2. "Amino" refers to a radical of the formula -NH2-. "Aminocarbonyl" refers to a radical of the formula -C (0) NH ,.

"Aminosulfonyl" refers to a radical of the formula -S (0) 2NH2. "Aryl" refers to a phenyl or naphthyl radical. The aryl radical may be optionally substituted by one or more substituents which are selected from the group consisting of hydroxy, mercapto, halo, alkyl, alkenyl, alkynyl, phenyl, phenylalkyl, phenylalkenyl, alkoxy, phenoxy, phenylalkoxy, haloalkyl, haloalkoxy, formyl, Nitro, cyano, cycloalkyl, hydroxyalkyl, alkoxyalkyl, phenoxy 1 quxy, phenylalkoxyalkyl, amidino, ureido, alkoxycarbonylamino, amino, monoalkylamino, dialkylamino, mono f in i 1 ami, monophenylalkylamino, sulfonylamino, alkylsulfonylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl , monophenylaminoalkyl, monophenylalkylaminoalkyl, acyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminocarbonylalkyl, monoalkylaminocarbonyl and dialkylaminocarbonylalkyl, as defined herein. "Aralkyl" refers to a radical of the formula -RaRb wherein Ra is an alkyl radical as defined above and Rb is an aryl radical as defined above, for example benzyl and the like. The aryl radical may optionally be substituted as described above. "Aryloxy" refers to a radical of the formula -ORb wherein Rb is an aryl radical as defined above, for example phenoxy and naphthoxy, and the like. The aryl radical may optionally be substituted as described above. "Aryloxycarbonyl" refers to a radical of the formula -C (0) ORb wherein Rb is an aryl radical as defined above, for example phenoxycarbonyl. "Aralkoxy" refers to a radical of the formula -0RC wherein Rc is an aralkyl radical as defined above, for example benzyloxy, and the like. The aralkyl radical optionally may be substituted as described above. "Aralkoxycarbonyl" refers to a radical of the formula -C (0) ORc wherein Rc is an aralkyl radical as defined above, for example benzyloxycarbonyl and the like. The aralkyl radical may be optionally substituted as described above. "Arylaminocarbonyl" refers to a radical of the formula -C (O) N (Rb) H wherein RD is an aryl radical as defined above, for example phenylaminocarbonyl and the like. The aryl radical may optionally be substituted as described above. "Arylaminosulfonyl" refers to a radical of the formula -S (0) 2N (Rb) H wherein Rb is an aryl radical as defined above, for example phenylaminosulfonyl and the like. The aryl radical optionally may be substituted as described above. "Aryisulfonyl" refers to a radical of the formula -S (0) 2 -Rb wherein Rb is an aryl radical as defined above, for example phenylsulfonyl and the like. The aryl radical optionally may be substituted as described above. "Arylsulfonylaminocarbonyl" refers to a radical of the formula -C (0) N (H) S (0) 2Rb wherein Rb is an aryl radical as defined above, for example phenylsulfonylaminocarbonyl and the like. The aryl radical optionally may be substituted as described above. "Acyl" refers to a radical of the formula -C (0) -Ra and -C (0) RD wherein Ra is an alkyl radical as defined above, and Rb is an aryl radical as defined above, for example acetyl, propionyl, benzoyl and the like. "Acylamino" refers to a radical of the formula -N (H) -C (0) -Ra and -N (H) -C (0) -Rb wherein Ra is an alkyl radical as defined above, and Rb is an aryl radical as defined above, for example acetylamino, benzoylamino and the like. "Alkylene" refers to a straight or branched chain divalent radical consisting solely of carbon and hydrogen, which does not contain saturations and which has 1 to 8 carbon atoms, for example methylene, ethylene, propylene, n-butylene and the like . The alkylene radical optionally may be substituted by one or more substituents which are selected from the group consisting of alkyl, hydroxy, -N (R16) R24 or -IOINIR'IR16, wherein R1, R16 and R21 are as defined in the foregoing , in the brief description of the invention. "Amino acid" refers to a divalent radical of the formula -N (R1) -R23-C (0) - wherein R1 is as described above in the brief description of the invention for R1 and R23 is an amino acid residue. "Amino acid residue" refers to the alkylene chain between the nitrogen atom and the carboxy group, which is substituted by various "side chains" of known amino acids. For example, the amino acid residues for the α-amino acids include carbon a (to which the carboxy group and the nitrogen atom are attached) and the side chain. For example, the amino acid residue of alanine is -C (CH3) -; the amino acid residue of serine is -C (CH; 0H) -, and so on. Therefore, it is understood that the term "amino acid" includes α-amino acids, β-amino acids, α-amino acids and so on, and all optical isomers thereof. Examples of such amino acids include alanine, asparagine, n-β-trityl-asparagine, aspartic acid, β-t-butylester of aspartic acid, arginine, N-tr-arginine, cysteine, S-trityl-cysteine, glutamic acid,? -t-butylester of glutamic acid, glutamine, N -? - trityl-glutamine, glycine, histidine, Nra-trityl-histidine, isoleucine, leucine, lysine, Nc-Boc-lysine, methionine, phenylalanine, proline, serine, Ot- butyl-serine, threonine, tryptophan, Nn-Boc-tryptophan (tyrosine, valine, sarcosine, L-alanine, chlorine-L-alanine, 2-aminoisobutyric acid, 2- (methylamino) isobutyric acid, D, L-3- acid aminoisobutyric, acid (R) - (-) -2-aminoisobutyric, (S) - (+) -2-aminoisobutyric acid, D-leucine, L-leucine, D-norvaline, L-norvaline, L-2-amino-4-acid pentenoic, D-isoleucine, L-isoleucine, D-norleucine, 2,3-diaminopropionic acid, L-norleucine, D, L-2-aminocaprylic acid, β-alanine, D, L-3-aminobutyric acid, 4- aminobutyric, acid 4- (methylamino) butyric acid, 5-aminovaleric acid, 5-aminocaproic acid, 7-aminoheptanoic acid, 8-aminocaprylic acid, 11-aminodecanoic acid, 12-aminododecanoic acid, carboxymethoxylamine, D-serine, D-homoserine, L-homoserine , D-halotreonin, L-halotreonin, D-threonine, L-threonine, D, L-4-amino-3-hydroxybutyric acid, D, L-3-hydroxynorvaline, (3S, 4S) - (-) - statin, 5-hydroxy-D, L-lysine, 1-amino-1-cyclopropanecarboxylic acid, 1-amino-1-cyclopentanecarboxylic acid, 1-amino-1-cyclohexanecarboxylic acid, 5-amino-1, 3-cyclohexadiene-1- carboxylic acid, 2-amino-norbornancarboxylic acid, (S) - (-) -2-azetidinocarboxylic acid, cis-4-hydroxy-D-proline, cis-4-hydroxy-L-proline, trans-4-hydroxy-L- proline, 3, 4-dehydro-D, L-proline, 3, 4-dehydro-L-proline, D-pipecolinic acid, L-pipelnylic acid, nipecotic acid, isonipecotic acid, mimosine, 2,3-diaminopropionic acid, acid D, L-2, 4-diaminobutyric acid, (S) - (+) - diaminobutyric acid, D-ornithine, L-ornithine, 2-methylornithine, Ne-methyl-L-lysine, N-methyl-D-aspartic acid, D, L-2-methylglutamic acid, D, L-2-aminoadipic acid, D-2- acid aminoadipic, L-2-aminoadipic acid, (+/-) -3-aminoadipic acid, D-cysteine, L-penicillamine, L-penicillamine, D, L-homocysteine, S-methyl-L-cysteine, L-methionine, D-ethionine, L-ethionine, S-carboxymethyl-L-cysteine, (S) (+) - 2-phenylglycine, (R) (-) -2-phenylglycine, N-phenylglycine, N- (4-hydroxyphenyl) glycine , D-phenylalanine, thienylalanine, (S) - (-) indole-2-carboxylic acid, α-methyl-D, L-phenylalanine, β-methyl-D, L-phenylalanine, D-homophenylalanine, L-homophenylalanine, DL -2-fluorophenylglycine, D, L-2-fluorophenylalanine, DL-3-fluorophenylalanine, D, -4-fluorophenylalanine, DL-4-chlorophenylalanine, L-4-chlorophenylalanine, 4-bromo-D, L-phenylalanine, 4- iodine-D-phenylalanine, 3, 3 ', 5-triiodo-L-thyronine, (+) - 3, 3', 5-triiodo-L-thyronine, D-thyronine, L-thyronine, D, Lm-torosine, D-4-hydroxyphenylglycine, D-tyrosine, t-tyrosine, 0-methyl-L -tyrosine, 3-fluoro-D, L-tyrosine, 3-iodo-L-tyrosine, 3-nitro-L-tyrosine, 3,5-diiodo-L-tyrosine, D, L-dopa, L-dopa, 2 , 4, 5-trihydroxyphenyl-D, L-alanine, 3-amino-L-tyrosine, 4-amino-D-phenylalanine, 4-amino-L-phenylalanine, 4-amino-D, L-phenylalanine, 4-nitro -L-phenylalanine, 4-nitro-D, L-phenylalanine, 3,5-dinitro-L-tyrosine, D, La-methyltyrosine, La-methyltyrosine, (-) -3- (3, 4-dihydroxyphenyl) -2 -methyl-L-alanine, D, L-threo-3-phenylserine, trans-4- (aminomethyl) cyclohexanecarboxylic acid, 4- (aminomethyl) benzoic acid, D, L-3-aminobutyric acid, 3-aminocyclohexanecarboxylic acid, cis-2-amino-1-cyclohexanecarboxylic acid, α-amino-β- (p-chlorophenyl) butyric acid (Baclofen), D, L-3-aminophenylpropionic acid, 3-amino-3- (4-c 1) orophenic acid 1) propionic, 3-amino-3 - (2-nitrophenyl) propionic acid, and 3-amino-4,4,4-trifluorobutyric acid. "Carbocyclyl" refers to a stable 3- to 15-membered ring radical consisting solely of carbon and hydrogen atoms. For purposes of this invention, the carbocyclyl radical may be a monocyclic, bicyclic or tricyclic ring system, and may include fused or bridging ring system, the ring system may be partially or completely saturated, or be aromatic, and carbon atoms in the ring system may optionally be oxidized. Examples of such carbocyclic radicals include, but are not limited to cycloalkyl radicals (as defined herein) norbornane, norbornene, adamantyl, bicyclo [2.2.2] octane, phenyl, naphthalenyl, indanyl, indenyl, azulenyl, fluorenyl, anthracenyl , and similar. The carbocyclyl ring may be substituted by R8 as described above in the brief description of the invention, or by one or more substituents that are selected from the group consisting of hydroxy, mercapto, halo, alkyl, alkenyl, alkynyl, phenyl, phenylalkyl, phenylalkenyl, alkoxy, phenoxy, phenylalkoxy, haloalkyl, haloalkoxy, formyl, nitro, cyano, cycloalkyl. , hydroxyalkyl, alkoxyalkyl, phenoxy-1-amino, phenylalkoxyalkyl, amidino, ureido, alkoxycarbonylamino, amino, monoalkylamino, dialkylamino, mon-ofenyl-1-amino, monophenylalkylamino, sulfonylamino, alkylsulfonylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, monophenylaminoalkyl, monophenylalkylaminoalkyl, acyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminocarbonylalkyl, monoalkylaminocarbonyl and dialkylaminocarbonylalkyl, as defined herein. "cycloalkyl" refers to a stable monocyclic or bicyclic radical of 3 to 10 members which is saturated, and which consists solely of carbon and hydrogen atoms, for example cyclopropyl, cyclobutyl, cyclohexyl, decalinyl and the like. Unless specifically stated otherwise in the specification, the term "cycloalkyl" means to include cycloalkyl radicals which are optionally substituted by one or more substituents that are independently selected from the group consisting of alkyl, halo, hydroxy, amino, cyano, nitro, alkoxy, carboxy and alkoxycarbonyl. "Carboxi" refers to the radical of the formula -C (0) OH. "Carboxyalkyl" refers to the radical of the formula -Ra-C (0) OH wherein Ra is an alkyl radical as defined above, for example carboxymethyl, 2-carboxyethyl, 3-carboxypropyl and the like. "Di (alkoxy) alkyl" refers to the radical of the formula -Ra (-ORa) _ wherein each Ra is independently an alkyl radical as defined above, and wherein the -0Ra groups can be attached at any carbon in the Ra group, for example 3, 3-dimethoxypropyl, 2,3-dimethoxypropyl and the like. "Dialkylamino" refers to the radical of the formula -N (Ra) Ra wherein each Ra is independently an alkyl radical as defined above, for example dimethylamino, diethylamino, (methyl) (ethyl) amino and the like. "Dialkylaminocarbonyl" refers to the radical of the formula -C (0) N (Ra) Ra wherein each Ra is independently an alkyl radical as defined above, for example dimethylaminocarbonyl, methylethylaminocarbonyl, diethylaminocarbonyl, dipropylaminocarbonyl, ethylpropylaminocarbonyl and the like. "Dialkylaminosulfonyl" refers to the radical of the formula -S (O) 2N (Ra) Ra wherein each Ra is independently an alkyl radical as defined above, for example dimethylaminosulfonyl, methylethylaminosulfonyl, diethylaminosulfonyl, dipropylaminosulfonyl, ethylpropylaminosulfonyl, and the like . "Halo" refers to bromine, chlorine, iodine or fluorine. "Haloalkyl" refers to an alkyl radical as defined above, which is substituted by one or more halo radicals, as defined above, for example trifluoromethyl, difluoromethyl, trichloromethyl, 2,2,2-trifluoroethyl, 1-fluoromethyl -2-fluoroethyl, 3-bromo-2-fluoropropyl, 1-bromomethyl-2-bromoethyl and the like. "Haloalkoxy" refers to a radical of the formula -0Rd, wherein each Rd is a haloalkyl radical as defined above, for example trifluoromethoxy, difluoromethoxy, trichloromethoxy, 2,2,2-trifluoroethoxy, 1-fluoromethyl-2-fluoroethoxy , 3-bromo-2-fluoropropoxy, 1-bromomethyl-2-bromoethoxy, and the like. "Heterocyclyl" refers to a stable ring radical of 3 to 15 members which consists of carbon atoms and 1 to 5 heteroatoms which are selected from the group consisting of nitrogen, oxygen and sulfur. For purposes of this invention, the heterocyclyl radical may be a bicyclic or tricyclic ring system, which may include fused or bridged ring system; and the nitrogen, carbon or sulfur atoms in the heterocyclyl radical optionally may be oxidized; the nitrogen atom optionally may be in quaternary form; and the heterocyclyl radical may be partially or completely saturated, or be aromatic. The heterocyclyl radical can be attached to the main structure at any heteroatom or carbon atom which results in the creation of a stable compound. Examples of heterocyclyl radicals include, but are not limited to, azepinyl, azetidinyl, acridinyl, benzimidazolyl, benzodioxolyl, benzodioxanyl, benzothiazolyl, benzoxazolyl, benzopyranyl, benzofuranyl, benzothienyl, carbazolyl, cinolinyl, decahydroisoquinolyl, dioxalanyl, furyl, isothiazolyl, quinuclidinyl, imidazolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, indolyl, isoindolyl, indolinyl, isoindolinyl, indolizinyl, isoxazolyl, isoxazolidinyl, morpholinyl, naphthyridinyl, oxadiazolyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperadinyl, 2-oxopyrrolidinyl, 2-oxoazepinyl, oxazolyl, oxazolidinyl, perhydroazepinyl, piperidinyl, piperazinyl, 4-piperidonyl, phenazinyl, phenothiazinyl, phenoxyzinyl, phthalazinyl, pteridinyl, pyrrolyl, pyrrolidinyl, pyrazolyl, pyrazolidinyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, quinazolinyl, quinoxalinyl, quinolinyl, quinuclidinyl, isoquinolinyl, thiazolyl or, thiazolidinyl, tladiazolyl, thiazolyl, tetrazolyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydroisoquinolyl, thienyl, thiomorpholinyl, thiomorpholinyl sulfoxide, and thiomorpholinyl sulfone. The heterocyclyl radical may optionally be substituted by R6 as defined above in the brief description of the invention, or may optionally be substituted by one or more substituents that are selected from the group consisting of hydroxy, mercapto, halo, alkyl, alkenyl, alkynyl, phenyl, phenylalkyl, phenylalkenyl, alkoxy, phenoxy, phenylalkoxy, haloalkyl, haloalkoxy, formyl, nitro , cyano, amidino, cycloalkyl, hydroxyalkyl, alkoxyalkyl, phenoxyalkyl, phenylalkoxyalkyl, amidino, ureido, alkoxycarbonylamino, amino, monoalkylamino, dialkylamino, monophenylamino, monophenylalkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, monofeni laminoalkyl, monofeni lalkylaminoalkyl, alkylcarbonyl, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, aminocarbonylalkyl, monoalkylaminocarbonyl, dialkylaminocarbonylalkyl and imidazolyl, as defined herein. "Linker residue" refers to any component capable of being selectively separated to release the residue of the compound of the invention from the solid substrate. See, for example, Greene and Wuts, Protective Groups in Organi c Syn thesis, 2nd ed., Willey (1991). The specific linker residues and the separation reagents thereof are described in Table 7 below. "Monoalkylamino" refers to a radical of the formula -N (H) Ra wherein Ra is an alkyl radical as defined above, for example methylamino, ethylamino, propylamino and the like. "Monoalkylaminocarbonyl" refers to a radical of the formula -C (0) N (H) Ra wherein Ra is an alkyl radical as defined above, for example methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl and the like.

"Monoalkylaminosulfonyl" refers to a radical of the formula -S (0) 2N (H) Ra wherein Ra is an alkyl radical as defined above, for example methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl and the like. "N-heterocyclyl" refers to a heterocyclyl radical as defined above, which contains at least one nitrogen atom and which is attached to the main structure through the nitrogen atom. The N-heterocyclyl radical can contain up to 3 additional heteroatoms. Examples include piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, azetidinyl, indolyl, pyrrolyl, imidazolyl, tetrahydroisoquinolyl, perhydroazepinyl, tetrazolyl, thiazolyl, oxazinyl and the like, and may optionally be substituted as described above for heterocyclyl radicals. In addition to being optionally substituted by the substituents included above for a heterocyclyl radical, the N-heterocyclyl radical may also be optionally substituted by R8 as defined above in the brief description of the invention. "Phenylalkyl" refers to an alkyl radical as defined above substituted by a phenyl radical, for example benzyl and the like. "Optional" or "optionally" means that event described subsequently of circumstances may or may not occur, and that the description includes cases in which such an event or circumstance occurs and cases in which it does not. For example "optionally substituted aryl" means that the aryl radical may or may not be substituted and that the description includes both substituted aryl radicals as well as aryl radicals which have no substitution. The term "- [C2-C8 alkyl] -R10 (optionally substituted by hydroxy)" means that the alkyl has the optional substitution. The same is true for the term "- [C 1 -C 8 alkyl] -R 11 (optionally substituted by hydroxy)". The term "-S (0) tR22 optionally substituted" means that all substituents R22 have the optional substitution. "Phenylalkenyl" refers to an alkenyl radical as defined above substituted by a phenyl radical. The term "pharmaceutically acceptable salt" refers to salts prepared from pharmaceutically acceptable non-toxic acids or bases including inorganic acids and bases and organic acids and bases. When the compounds of the present invention are basic, the salts can be prepared from pharmaceutically acceptable non-toxic acids including inorganic and organic acids. The pharmaceutically acceptable acid addition salts suitable for the compounds of the present invention include acetic acid, benzenesulfonic (besylate), benzoic, camphorsulfonic, citric, otonsulfonic, fumaric, gluconic, glutamic, hydrobromide, hydrochloride, isethonic, lactic, maleic, malic, mandelic, methanesulfonic, mucic, nitric, parmoic, pantothenic, phosphoric, succinic, sulfuric, tartaric, p-toluenesulfonic and the like. When the compounds contain an acidic side chain, the pharmaceutically acceptable base addition salts suitable for the compounds of the present invention include metal salts consisting of aluminum, calcium, lithium, magnesium, potassium, sodium and zinc, or organic salts made from Lysine, N, N'-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N-methylglucamine) and procaine. "Solid substrate" refers to a material on which the synthesis of the compounds of the invention is going to be performed, and is also referred to herein as spheres or resins. The term "solid substrate" is intended to include spheres, granules, discs, fibers, gels or particles such as cellulose spheres, porous glass spheres, silica gel, polystyrene spheres optionally crosslinked with divinylbenzene and optionally grafted with polyethylene glycol and optionally functionalized with amino, hydroxy, carboxy or halo groups, copolyzed spheres, polyacrylamide spheres, latex spheres, dimethylacrylamide spheres optionally crosslinked with N, N'-bis-acryloylethylenediamine, glass particles coated with hydrophobic polymer, etc., i.e. , material that has a rigid or semi-rigid surface; and soluble substrates such as low molecular weight, non-crosslinked polystyrene. "Therapeutically effective amount" refers to that amount of a compound of the invention which, when administered to a human in need thereof, is sufficient to carry out the treatment, as defined below, for conditions resulting from an abnormality in the production of nitric oxide. The amount of a compound of the invention which constitutes a "therapeutically effective amount" will vary depending on the compound, the condition and its severity, and the age of the human concerned, but can usually be determined by a person familiar with the art. Take into consideration your own knowledge and this description. "Treat" or "treatment", as used herein, covers the treatment of a condition in a human, a condition which results from an abnormality in the production of nitric oxide, and includes: (i) preventing the occurrence of condition in a human, in particular when such a human is predisposed to the condition but has not yet been diagnosed as a patient who presents it: (ii) inhibition of the condition, ie, suppression of its development; or (iii) release of the condition, that is, regression of the condition. The yield of each of the reactions described herein is expressed as a percentage of the theoretical yield. Most of the compounds described herein contain one or more asymmetric centers and therefore give rise to enantiomers, diastereomers and other stereoisomeric forms which can be defined, in terms of absolute stereochemistry as (R) - or (S) - or, as (D) - or (L) -for amino acids. The present invention is intended to include all of all possible isomers, as well as their racemic and optically pure forms. The optically active isomers (R) - and (S) - or, (D) - and (L) - can be prepared using chiral synthons or chiral reagents, or they can be separated using conventional techniques. When the compounds described herein contain olefinic double bonds or other centers of geometric asymmetry, unless otherwise specified, it is understood that the compounds include the geometric isomers E and Z. Likewise, all tautomeric forms are also they pretend they are included. The nomenclature used in this is a modification of the naming system of the I.U.P.A.C. wherein the compounds of the invention are referred to herein as amide derivatives. For example, the following compound of the invention: it is referred to herein as 2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [(4-methoxyphenyl) methyl] -pentanediamine. Unless otherwise indicated, it is intended that the names of the compounds include any simple stereoisomer, enantiomer, racemate or mixtures thereof.

UTILITY OF THE COMPOUNDS OF THE INVENTION: Nitric oxide generated by the inducible form of nitric oxide synthase (i-NOS) has been implicated in the pathogenesis of many inflammatory and autoimmune diseases and also diseases which are generally not considered to be inflammatory but which nevertheless may involve cytokines which they locally regulate the i-NOS.

The compounds of the invention, alone or in combination with other pharmaceutical agents, are therefore useful for treating mammals, preferably humans, having a condition resulting from an abnormality in the production of nitric oxide.

Such conditions include, but are not limited to the following: Multiple sclerosis (Parkinson, J.F. et al., Mol. Med. (1997), vol. 75, pp. 174-186); attack or cerebral ischemia (Iadecola, C. et al., J. Neurosci. (1997), vol.17, pp. 9157-9164); Aizheimer's disease (Smith M.A., et al., J. Neurosci. (1997), vol. 17, pp. 2653-2657; Wallace, M.N. et al. Exp.

Neurol. (1997), vol. 144, pp. 266-272); dementia for HIV (Adamson D.C., et al., Science (1996), vol 274, pp. 1917-1921); Parkinson's disease (Hunot, S. et al., Neuroscience (1996), vol 72, pp. 355-363); meningitis (Koedel, U. et al., Ann.

Neurol. (1995), vol. 37, pp. 313-323); Dilated cardiomyopathy and congestive heart failure (Satoh M. et al., Am. Coil, Cardiol. (1997), vol. 29, pp. 716-724); atherosclerosis (Wilcox J.N. et al., Arterioscler, Thromb, Vesc. biol. (1997), vol, 17, pp. 2479- 2488); restenosis or graft stenosis, septic shock and hypotension (Petros, A. et al., Cardiovasc Res (1994), vol 28, pp. 34-39); Hemorrhagic shock (Thiemermann, C. et al., Proc.

Na ti. Acad. Sci. (1993), vol. 90, pp. 267-271); asthma (Barnes, P.J. et al., Ann. Med. (1995), vol.27, pp. 389-393; Flak, T.A. et al. Am. J. Respir. Crit. Care Med. (1995), vol. 154, pp. 5202-5206); respiratory distress syndrome in adults, smoking habit or particle-mediated lung damage (Ischiropoulos, H. et al., Am. J. Respir. Crit. Care Med. (1994), vol 150, pp. 337-341; Dyke, K., Agents Actions (1994), vol 41, pp. 44-49); pneumonias mediated by pathogens (Adler, H. et al., J. Exp. Med. (1997), vol 185, pp. 1533-1540); traumas of various etiologies (Thomas, K.R. et al., Surgery (1996), vol 119, pp. 61-66); rheumatoid arthritis and osteoarthritis (Grabowski P.S. et al., Br. J. Rheumatol. (1997), vol 36, pp. 651-655); glomerulonephritis (Weinberg, J.B. et al., Exp. Med. (1994), vol 179, pp. 651-660); systemic lupus erythematosus (Belmont, H.M. et al., Arthritis Rheum. (1997), vol 40, pp. 1810-1816); inflammatory bowel diseases such as ulcerative colitis and Crohn's disease (Godkin, JA et al., J. Clin. Invest. (1996), vol.26, pp. 867-872; Singer, II et al., Gastroesterology (1996 ), vol 111, pp. 871-885); insulin-independent diabetes mellitus (McDaniel, M.L. et al., Proc. Soc. Exp. Biol. Med. (1996), vol.211, pp. 24-32); Diabetic neuropathy or nephropathy (Sugimoto, K. and Yagihashi, S. Microvasc. Res. (1997), vol 53, pp. 105-112; Amore A. et al., Kidney Int. (1997), vol 51, pp. 27-35); acute and chronic organ transplant rejection (Worral, N.K. et al., Transplatation (1997), vol 63, pp. 1095-1101); Transplant vasculopathies (Russel, M.E, et al. (1995), vol.92, pp. 457-464); graft versus host disease (Klohian, K. et al J. Immunol. (1996), vol 157, pp. 2851-2856); psoriasis and other inflammatory skin diseases (Bruch-Gerharz, D. et al., J. Exp. Med. (1996), vol 184, pp. 2007-2012); and cancer (Thomsen, L.L., et al.Cancer fies. (1997), vol.57, pp. 3300-3304). The compounds of the present invention may also be useful for the management of male and female reproductive functions when used alone or in combination with other medications commonly used for these indications. Examples, without limitation involved, include: fertilization inhibition, endometrial receptivity and implantation (alone or in combination with a progesterone antagonist); post-coital contraception (alone or in combination with a progesterone antagonist); induction of abortion (in combination with an antiprogestin and in additional combination with a prostaglandin); control and management of labor and delivery; treatment of servical incompetence (alone or in combination with progesterone or a progestin); endometriosis treatment (alone or in combination with other drugs, including LHRH agonist / antagonist, antiprogestin, orprogestins either by sequential application or by simultaneous administration). See, for example, the following references: Chwalisz, K. et a l. J. Soc. Gynecol. Invest. (1997), vol. 4, No. 1 (supplement), page 104a, which discusses the inhibition of fertilization, endometrial receptivity and implantation, or post-coital contraception, alone or in combination with a progesterone antagonist; Chwalisz, K. et al. Prens t. Neona t. Med. (1996), vol. 1, pp. 292-329, which discusses the induction of abortion, in combination with an antiprogestin and in additional combination with a prostaglandin, and the control and management of labor and delivery; and Chwalisz K. et ai. Hum. Reprod. (1997), vol. 12. pp. 101-109, which discusses the treatment of servical incompetence, alone or in combination with progesterone or a progestin. Those familiar with the art will also recognize that the compounds of the present invention include 1-substituted imidazoles. This class of compounds has previously been described as heme-binding inhibitors based on the mechanism of the cytochrome P450 family of enzymes (Maurice, M. et al, FASEB J. (1992), VOL 6, PP 752-8). of nitric oxide synthesis (Chabin, R.NM. et al., Biochemistry (1996), vol.35, pp. 9567-9575). The compounds of the present invention can therefore be useful as inhibitors of selected cytochrome P450 family members of therapeutic interest including, but not limited to, P450 enzymes involved in the biosynthesis of steroids and retinoids (Masamura et al., Beast Cancer Res. Trea t. (1995), vol 33. pp. 19-26); S art, P. et a l. J. Clin. Endocrinol Metab, vol. 77. pp. 98-102; Docks, P. et al. Br. J. Derma tol. (1995), vol. 133, pp. 426-32) and cholesterol biosynthesis (Burton, P.M. et al.

Biochem. Pharmacol. (1995), vol. 50, pp. 529-544; and S inney, D.C. et al. Biochemistry (1994), vol. 33, pp. 4702-4713). The imidazole-based compounds may also have antifungal activity (Abyama, Y. et al I. Biochem., Pharmacol. (1992), vol 44, pp. 1701-1705). The P450 inhibitory activity of the compounds of the present invention can be determined using appropriate assay systems specific for the P450 isoform of interest. Such assays are included in the references mentioned above. A further example of a mammalian cytochrome P450 isoform that can be inhibited by the compounds of the present invention is cytochrome P450 3A4 which can be tested in a manner similar to the method described in Yamazaki et al. Carcinogenesis (1995), vol. 16, pp. 2167-2170.

PROOF OF THE COMPOUNDS OF THE INVENTION Nitric oxide synthases are complex enzymes that catalyze the conversion of N-arginine (NO) and citrulline. The catalysis is carried out through two successive oxidations of the guanidinium group of L-arginine. For the evaluation of the compounds of the invention, a cell-based nitric oxide synthase assay was used, which uses the measurement of the oxidation product of nitric oxide, nitrite, in the conditioned medium of cultured cells. The monocytic mouse cell lines RAW 264.7 and J774 are well documented as being able to produce > 10 μM nitrite in response to immunostimulation: INDUCTION OF INOS IN MOUSE MONOCITE RAW 264.7 RAW 264.7 mouse macrophage cells are obtained from American Type Culture Collection (Rockville, Maryland) and maintained in RPMI 1640 containing 10% fetal bovine serum (FBS), 5,000 units / ml penicillin and streptomycin, and 2 mM glutamine. (maintenance medium). The NOS activity is measured by a fluorescence assay of the nitric oxide oxidation product, nitrite (Diamani et al I. Talan ta (1986), vol 33, pp. 649-652). The induction of iNOS (inducible nitric oxide synthase) is stimulated by treatment of the cell with lipopolysaccharide and interferon? The test method is described below. The cells are harvested, diluted to 500,000 cells / ml with maintenance medium and seeded in 96-well plates at 100 μl / well. The plates are incubated overnight at 37 ° C, under an atmosphere of C02 5%. Then the medium is replaced with 90 μl of BME medium containing 10% FBS, 100 units / ml of penicillin, 100 μl of streptomycin, 2 mM glutamine, 100 units / ml of interferon? and 2 μg / ml of lipopolysaccharide. N-guanidino-methyl-L-arginine (negative control) is added to 4 wells at a final concentration of 200 μM using 10 μl of 2 mM concentrated solution in 100 mM Hepes, pH 7.3 + 0.1% DMSO and 4 wells received only Hepes 100 mM / 0.1% DMSO buffer (positive control). The compounds for evaluation are dissolved 10 times at the desired final concentration in Hepes / DMSO and 10 μl of these solutions are transferred to a 96-well plate. The plates are incubated for 17 h at 37 ° C under an atmosphere of C02 5%. The nitrite accumulated in the culture medium is determined as follows: 15 μl of 2,3-diaminonaphthalene (10 μg / ml in 0.75 M HCl) is added to each well, and incubated for 10 minutes at room temperature. 15 μl of IN NaOH are added and the fluorescence emission is measured at 405 nm, using an excitation wavelength of 365 nm. Enzymatic activity in experimental wells is normalized to the control percent using the positive and negative control values. The ratio of signal to noise is > 10 for the trial. The compounds of the invention, when tested in this assay, demonstrate the ability to inhibit the production of nitric oxide. Various in vivo assays can be used to determine the efficacy of the compounds of the invention to treat a condition resulting from an abnormality in the production of nitric oxide, such as arthritis. The following is a description of such an assay using rats: EFFECTS OF THE COMPOUNDS OF THE INVENTION ON INDUCED ARTHRITIS BY ADJUVANT IN RATS Male Lewis rats were injected intradermally (proximal of the tail) with 0.1 ml of Mycobacterium um bu tyri cum in incomplete Freund's adjuvant (10 mg / ml). It is administered subcutaneously (bid) either vehicle (acidified saline solution, 1 ml / kg) or a compound of the invention (3, 10 or 30 mg / kg), starting on the day after adjuvant immunization, and continuing until the end of the experiment (N = 10 rats per treatment group). Clinical classifications (see below) are measured in all extremities, three times a week, during the study. Rats were sacrificed 34-35 days after immunization. At the time of euthanasia, a biological evaluation (see below) of the hind limbs was performed, a blood sample was collected for clinical blood chemistry and drug levels (only the high dose group, 6 to 12 hours after the final dose), a liver section was obtained to measure potential toxicity and the hind limbs were preserved for histopathological determination. Clinical classification - each member was classified according to the following scale: 0 without signs of inflammation 1 moderate redness, first indication of swelling, flexible joint 2 moderate redness, moderate swelling, flexible joint 3 redness, significant swelling and distortion of the leg, the joint begins to fuse 4 redness, thick swelling and distortion of the leg, the joint is completely fused.

Radiological classification - each hind limb is classified on a scale of 0-3 for each of the following parameters: swelling of soft tissue loss of cartilage erosion classification heterotropic The compounds of the invention, when tested in this assay, demonstrate the ability to treat arthritis present in rats. Those familiar with the art will also recognize that there are numerous assays for the activity of the NOS isoforms (iNOS, nNOS and eNOS) which can be used to evaluate the biological activity of the compounds of the present invention. These incubate assays for native NOS isoforms in tissues studied ex vivo (Mitchell et al., Br. J. Pharmacol. (1991), vol 104. pp. 289-291; Szabo et al., Br. J. Pharmacol., 1993. ), vol.108, pp. 786-792; Joly et al., Br. J. Pharmacol. (1995), vol 115, pp. 491-497) as well as primary cell cultures in cell lines (Forstermann et al. Eur. J. Pharmacol. (1992), vol.225, pp. 161-165; Radmoski et al., Cardiovasc. Res. (1993), vol.27, pp. 1380-1382; Wang et al., J. Pharmacol Exp. Ther. (1994), vol.268, pp. 552-557). Those familiar with the art will also recognize that recombinant NOS enzymes can be expressed in heterologous cells either by transient transfection (Karisen et al., Diabetes (1995), vol.44, p.753-758), stable transfection (McMillan et al. Proc. Nati, Acad. Sci. (1992), vol.89, pp. 11141-11145, Sessa et al., J. Biol. Chem. (1995), vol.270, pp. 17641-17644) or by means of lytic virus transaction use (Buscón &Michel, Mol.Pharmacol. (1995), vol.47, pp. 655-659; List et al., Biochem. J. (1996), vol.315, p. 57-63) using cDNA for NOS. Heterologous expression can be obtained in mammalian cells ((McMillan et al., Proc. Nati, Acad. Sci. (1992), vol. 89, pp. 11141-11145), insect cells (Buscon & Michel, Mol. Pharmacol. (1995), vol. 47, pp. 655-659; List et al. Biochem. J. (1996), vol. 315, pp. 57-63), yeast (Sari et al., Biochemistry (1996), vol 35. pp. 7204-7213) or bacteria (Román et al., Proc. Na ti. Acad. Sci. (1995), vol. , pp. 8428-8432; Martasek et al., Biochem. Biophys., Res. Commun. (1996), vol. 219, pp. 359-365). Any of these heterologous expression systems can be used to establish assay systems for iNOS, nNOS and eNOS, to evaluate the biological activity of the compounds of the present invention.

ADMINISTRATION OF THE COMPOUNDS OF THE INVENTION Any suitable route of administration can be used to provide a patient with an effective dosage of compounds of the invention. For example, oral, rectal, parenteral (subcutaneous, intramuscular, intravenous), transdermal, and similar administration forms can be used. Dosage forms include tablets, troches, dispersions, suspensions, solutions, capsules, patches and the like. The pharmaceutical compositions of the present invention comprise the compounds of the invention as the active ingredient, and may also contain a pharmaceutically acceptable carrier, and optionally other therapeutic ingredients. Carriers such as starches, sugars and microcrystalline cellulose, diluents, granulating agents, lubricants, binders, disintegrating agents and the like are suitable in the case of oral solid preparations (such as powders, capsules and tablets), and oral solid preparations are preferred. about oral liquid preparations. Methods for their preparation are well known in the art. Because of their ease of administration, tablets and capsules represent the most advantageous oral dosage unit forms, in which case solid pharmaceutical carriers are used. If desired, the tablets can be coated by standard aqueous or non-aqueous techniques. In addition to the common dosage forms set forth in the foregoing, the compounds of the present invention may also be administered by a controlled or sustained release means and by delivery device. The pharmaceutical compositions of the present invention suitable for oral administration can be presented as discrete units such as capsules, sachets or tablets, each with a predetermined amount of the active ingredient, as a powder or granules, or as a solution or suspension in a liquid aqueous, a non-aqueous liquid, an oil-in-water emulsion or a water-in-oil liquid emulsion. Such compositions may be prepared by any of the pharmacy methods, but all methods include the step of bringing into association the active ingredient with the carrier which constitutes one or more of the necessary ingredients. In general, the compositions are prepared by uniform and intimate mixing of the active ingredient with liquid carriers or finely divided solid carriers or both and then, if necessary, with formation of the product at the desired presentation.

PREFERRED MODALITIES In the various aspects of the invention, certain embodiments are preferred. A preferred group of compounds of formula (I), formula (II), and formula (III), are those compounds of formula (I) having the formula (Ia), formula (Ib), or formula of): A preferred subgroup of this group of compounds are those compounds wherein A is -OR1, -C (O) N (R1) R2, -N R ^ UOJNÍR R16, -NR ^ OJR2 or -N (R2) R24; V is N (R4); and W is CH.

A preferred class of compounds of this subgroup are those compounds wherein A is -C (0) N (R1) R2; q, r and n are zero; R1 is hydrogen; R2 is lower alkyl or - [X-CgJ-R9; R 4 is hydrogen or lower alkyl; and R5 is hydrogen, halo, alkyl or alkoxy. A preferred subclass of compounds of this class of compounds are those compounds wherein R9 is phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, chlorophenyl, carboxyphenyl, dimethoxyphenyl, 2-thienyl or morpholinyl. Another preferred subgroup of compounds of this group of compounds are those compounds wherein A is -C (0) N (R1) R2; m is zero; Q is a direct link for R3; and R3 is hydrogen. A preferred compound of this subgroup is N - [(1, 3-benzodioxol-5-yl) ethyl] -2- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] acetamide. Another preferred group of compounds of formula (I), formula (II) and formula (III) are the compounds of formula (II), having the formula (lia), formula (Ilb), and formula (lie): A preferred subgroup of compounds of this group of compounds are those compounds wherein N-heterocyclyl are selected from the group consisting of piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, acetidinyl, indolyl, pyrrolyl, imidazolyl, tetraisoquinolyl and perhydroazepinyl. A preferred class of compounds of this subgroup of compounds are those compounds wherein N-heterocyclyl is piperazinyl substituted by R8, ie, the compounds of formula (lid), formula (He), or formula (Hf): He); or A preferred subclass of compounds of this class of compounds are those compounds wherein A is -OR1, -UOWR ^ R2, -NÍR ^ JCÍOÍNÍR ^ R16, -NRXíOR2 O -NfR ^ R24; W is CH; and R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl of X-Cg -R8, - [C2-C8 alkyl] -R10, - [Ci-Cg alkyl] -Ru, acyl ,, -C (0) R8, -C (O) - [C_-C8 alkyl] -R8, alkoxycarbonyl, optionally substituted alkoxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted aryisulfonyl , aminocarbonyl, monoalkylcarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (O) -R23-N (R1 ) R2, -C (0) -R23-N (R1) C (0) -R23-N (R1) R2 and -C (O) -N (R1) -R23-C (O) OR1. Of this subclass of compounds, the preferred compounds are those compounds wherein A is -C (O) N (R1) R2; R1 is hydrogen; R2 is lower alkyl, - [alkyl of X-C-R9, or - [C_-C8] -R10; R5 is hydrogen, acetyl, t-butoxycarbonyl, 4-methoxyphenylaminocarbonyl, 4-methoxyphenylmethyl, methoxycarbonyl, methyl or benzyl; R5 is hydrogen, halo, alkyl or alkoxy; and n is zero or 1. Of this group of preferred compounds, the most preferred compounds are those compounds wherein R2 is -CH2-R9 or - [C_-C8] -R10; R9 is aryl or substituted aryl; and R10 is methylthio. Of this group of more preferred compounds, the most preferred compounds are those compounds wherein R2 is -CH2-R9; R6 is hydrogen, acetyl or t-butoxycarbonyl; and R9 is phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, methylthiophenyl, chlorophenyl, carboxyphenyl, dimethoxyphenyl or 2-thienyl. Of this group of more preferred compounds, the preferred compounds are those compounds wherein R5 is chloro, R8 is acetyl and R9 is p-tolyl, or those compounds wherein R5 is chloro, R6 is hydrogen and R9 is p-tolyl , or those compounds in which R5 is chloro, R6 is hydrogen and R9 is 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl, or those compounds in which R5 is chloro, R6 is t -butoxycarbonyl and R9 is 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl. Preferred compounds of this subset of compounds can be selected from the following list: N- [(1,3-benzodioxol-5-yl) ethyl] -4- [2- (lH-imidazol-1-yl) -6- methylpyrimidin-4-yl] -1- (2-methyl-l-oxopropyl) piperazin-2-acetamide; N- [(1, 3-benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -4- (methoxycarbonyl) piperazine-2- acetamide; N - [(1,4-benzodioxan-6-yl) methyl] -1- [2- (lH-triazol-1-yl) pyrimidin-4-yl] - A - (dimethylethoxy) piperazine-2-acetamide; N- [(1,3-benzodioxol-6-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methoxypyrimidin-4-yl] -1- (methoxycarbonyl) piperazin-2 acetamide; 1- (acetyl) -N- [(1,3-benzodioxol-5-yl) methyl] -4- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (methylsul fonyl) piperazin-2 acetamide; and l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(pyridin-3-yl) methyl] -4- (tetrahydro-3-furanoyl) piperazine-2-carboxamide. Another preferred class of compounds of this subgroup of compounds are those compounds wherein N-heterocyclyl is piperidinyl, ie, the compounds of formula (Hg), formula (Hh), or formula (Ili): A preferred subclass of compounds of this class of compounds are those compounds wherein A is -OR1, -UOJNtR ^ R2, -N (R16) C (0) N (R1) R16, -NRXfOR2 or -N (RX) R21; and W is CH; Preferred compounds of this subclass of compounds are those compounds wherein A is -C (0) N (R1) R2; R1 is hydrogen; R2 is lower alkyl or - [alkyl of X-Cgj-R9; R5 is hydrogen, halo, alkyl or alkoxy; and n is zero or 1. The most preferred compounds of these preferred compounds are those compounds wherein R2 is lower alkyl or -CH2-R9 and R9 is 4-methoxyphenyl, 1, -benzodioxan-6-yl, 1,3-benxodiozole -5-yl or 3,4-dimethoxyphenyl. Preferred compounds of this subgroup of compounds can be selected from the following list: N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4 -yl] piperidin-2-ethane ina; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (morpholin-4-yl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- (methylhexyl) piperidin-2-acetamide; N- [(4-chlorophenyl) methyl] -1- [2,6-bis (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperidin-2-acetamide; and N- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methoxypyrimidin-4-yl] piperidin-2-acetamide. Another preferred class of compounds of this subgroup of compounds are those compounds wherein N-heterocyclyl is pyrrolidinyl, ie, the compound of formula (IIj), formula (Hk), or formula (Hm): A preferred subclass of compounds of this class of compounds are those compounds wherein A is -OR1, -C. { 0) li. { R1) R2, -NÍR ^ CÍOJNÍR R16, -NRX (O) R2 O -N (R1) R21; and W is CH; Preferred compounds of this subclass of compounds are those compounds wherein A is -C (O) N (R1) R2; R1 is hydrogen; R2 is lower alkyl or - [alkyl of X-Cgj-R9; R5 is hydrogen, halo, alkyl or alkoxy; and n is zero or 1. The most preferred compounds of these preferred compounds are those compounds having the R-C configuration of the pyrrolidinyl ring. Preferred compounds of this subset of compounds can be selected from the following list: N- [(1,3-benzodioxol-5-yl) ethyl] -4- [2- (lH-imidazol-1-yl) -6- methylpyrimidin-4-yl] -pyrrolidine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] -pyrrolidine-2-carboxamide; N - [(3,4-dimethoxy phenyl) methyl] -1- [2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -pyrrolidin-2-acetamide; N - [(4-methoxy phenyl) ethyl] -1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -pyrrolidine-2-carboxamide; and N- [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] -pyrrolidin-2-acetamide. Additional preferred compounds from the group of compounds as defined above may be selected from the following list: 4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3 -benzodioxol-5-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] thiomorpholin-2-acetamide; N- [(1,3-dioxolan-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -perhydroazepin-2-acetamide; N- [(3, -dimethoxyphenyl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -acetidine-2-carboxamide; and 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] morpholine-2-carboxamide. Another preferred group of compounds of formula (I), formula (II), and formula (III) are those compounds of formula (III) having the formula (Illa), formula (IHb), or formula (IIIc): A subgroup Preferred compounds of this group of compounds are those compounds in which is optionally substituted phenyl or optionally substituted naphthyl. Another preferred group of compounds of formula (I), formula (II), or formula (III) are those compounds in which each of X, Y or Z is C (R19) and each U is C (R6). Another preferred group of compounds of formula (I), formula (II), or formula (III) are those compounds in which each of X, Y or Z is N and each each U is C (R5). Another preferred group of compounds of formula (I), formula (II), or formula (III) are those compounds wherein each of X, Y or Z is C (R19) and each U is N. Another preferred group of compounds of formula (I), formula (II), or formula (III) are those compounds in which, in each formula, one of X, Y and Z is N and the others are C (R19) and U is C ( R5).A preferred group of compounds of formula (IV) are those compounds of formula (IVa), formula (IVb), or formula (IVc): A preferred subgroup of compounds of this group of compounds are those compounds in which the amino acid is an α-amino acid of the L configuration on the carbon with respect to the acid. Another preferred subgroup of compounds of this group of compounds are those compounds in which the amino acid is an α-amino acid of the D configuration on the carbon with respect to the acid. Another preferred subgroup of compounds of this group of compounds are those compounds wherein R 1 is hydrogen; R2 is lower alkyl or - [alkyl of X-Cg-R9; and R5 is hydrogen, halo, alkyl or alkoxy. A preferred class of compounds of this subgroup of compounds are those compounds wherein R9 is phenyl, tolyl, anisyl, 1,4-benzodiozan-6-yl, 1,3-benzodioxol-5-yl, chlorophenyl, carboxyphenyl, 2- thienyl, dimethoxyphenyl or morpholinyl. A preferred group of compounds of formula (Va), formula (Vb), or formula (Ve) are those compounds wherein each X and each Y is N; each W is CH; and V is an optionally substituted fumed heterocyclyl. A preferred subgroup of compounds of this group of compounds are those compounds having the formula (Vba): wherein A is -OR1, -C (O) N (R1) R2, -N (R16) C (O) N (R1) R16, NR! C (0) R2 or -NfR ^ R21; Y is N-heterocyclyl which is selected from the group consisting of piperidinyl, piperazinyl, pyrrolidinyl or morpholinyl. A preferred compound of this subgroup of compounds is N- [(1,3-benzodioxol-5-yl) methyl] -1 [2- (lH-imidazol-1-yl) purin-6-yl] piperidin-2-acetamide . Of the compounds of formula (Vlla), formula (Vllb), or formula (VIIc), a preferred compound is N- [(1,3-benzodioxol-5-yl) methyl] -l [6-chloro-2- ( pyridin-3-yl) pyrimidin-4-yl] piperidin-2-acetamide. Of the compounds of formula (VIII), preferred are 4,6-dichloro-2- (lH-imidazol-1-yl) pyrimidine and 2,4-dichloro-6- (1-lH-imidazol-1-yl) pyrimidine. Of the binder residues used in this invention, the photolitically separable bond of formula (X) is most preferred: where the valency not satisfied to the right of the formula represents the point of attachment to the solid substrate, and the valence not satisfied to the left of the formula represents the point of binding to the ligand.

PREPARATION OF THE COMPOUNDS OF THE INVENTION The compounds of the invention can be synthesized by two general approaches, one of which (solid phase) can be considered as a variant of the other (phase in solution). The generic synthesis of phase in solution is shown in the following reaction scheme 1 which, solely for purposes of illustration, illustrates the synthesis of a compound of formula (I) wherein A is -C (0) N (R1) R2 . It is understood that other compounds of the invention can be prepared in a similar manner. In the following reaction scheme 1, PG is a suitable protecting group; m, n, q, r, Q, U, W, X, Y and Z are as described in the above in the summary of the invention; V is N (R4), S or 0 (wherein R4 is as described in the brief description of the invention); and R1. R2, R3, R12, R13, R14, R15, R17 and R20 are as described above, in the brief description of the invention: Reaction scheme 1 (XlVaa) Vbb) (XIVcc) In general, the compounds of formula (I) are prepared by first adding one equivalent of a compound of formula (XI) in one portion, to a solution of one equivalent of a compound of formula (XII) having at least two substituents displaceable by a nucleophile and 1.1 equivalents of trialkylamine base (such as triethylamine) in a non-protic polar solvent such as THF or methylene chloride, to provide the compound of formula (XIII). Upon completion of the reaction, the mixture is purified by conventional methods. The compounds of formula (XIVcc) are synthesized by methods well known in the art of amino acid and peptide synthesis from the appropriate compound of formula (XlVaa) wherein PG is a standard protecting group for the V substituent. The compounds of formula ( XlVaa) are commercially available, usually in protected form, or are easily synthesized by methods well known in the art. Preferred protecting groups are Boc (t-butoxycarbonyl) and Fmoc (fluorenylmethoxycarbonyl), although others, such as CBZ (benzyloxycarbonyl) and Troc (trichloroethoxycarbonyl) can be used for particular circumstances. The side chain functionalities can be protected, as is well known in the peptide art, by Trt (triphenylmethyl), tBu (t-butyl), Acm (acetamidomethyl), etc. The protected compounds of formula (XlVaa) are reacted with the appropriate amine to produce compounds of formula (XlVbb) and deprotected to produce the compound of formula (XIVcc), again by methods well known in the art of peptides.

An equivalent of the compound of formula (XIVcc) is added to a solution of one equivalent of the compound of formula (XIII) and a base equivalent in an aprotic, polar solvent, such as THF. The reaction is heated to a temperature at which the reaction is carried out cleanly until completion in less than 16 hours. At the end of the reaction, the compound of formula (I) is purified and characterized by conventional methods. The compounds of formula (I) have what is called "reverse amide", that is, wherein A is -N (R1) C (0) R2 and can be manufactured from the appropriate acid of formula (XlVaa) by Hofmann rearrangement of the acid to an amine, followed by acylation with an appropriate acid under the conditions described above. In many cases, the desired diamine can be obtained commercially. The compounds of formula (I) in which A is a urea can be prepared by reacting a compound of formula (I) wherein A is -NfR ^ R21 (wherein R1 is hydrogen and R21 is hydrogen, alkyl, aryl or aralkyl) with an isocyanate. Similarly, compounds of formula (I) in which A is a carbamate can be prepared by reacting a compound of formula (I) (wherein A is -N (RX) R21 wherein R1 is hydrogen and R21 is hydrogen, alkyl, aryl or aralkyl) with an alkyl chloroformate or by curtius rearrangement of the carboxylic acid azide of the compound of formula (XlVaa) in the presence of the appropriate alcohol. In the reaction scheme 2, a specific embodiment of the generic synthesis of a compound of the invention is shown below, as applied to 6-chloro-2- (1-imidazolyl) -4-pyrimidinamine which incorporates the D-β residue -thienilalanine piperonilamide: Reaction scheme 2 (Villa) One equivalent of isobutyl cloformate is added to a solution of N-Boc-D-β-thienylalanine and one equivalent of a phase such as N-methylmorpholine in THF. After two minutes, one equivalent of piperonylamine is added and the mixture is allowed to warm to room temperature. After thirty minutes, the reaction mixture is passed through a Celite bed and all volatile factions are removed under reduced pressure to provide N-Boc-D-β-thienylalanine piperonyl amide. The N-Boc-D-β-thienylalanine piperonyl amide is treated with methanol with acetyl chloride. After 45 minutes, all volatile fractions are removed under reduced pressure to provide D-β-thienylalanine piperonyl amide hydrochloride. One equivalent of imidazole is added in one portion, to a solution of one equivalent of trichloropyrimidine and 1.5 equivalents of triethylamine in THF. After the reaction is complete, the reaction mixture is poured into saturated aqueous ammonium chloride and extracted three times with ethyl acetate. The combined organic layers are washed with brine and dried. The reaction mixture is filtered and all volatile fractions are removed under reduced pressure. The product 2-imidazolyl-4,6-dichloropyrimidine (the compounds of the formula (Villa)) are isolated by flash chromatography (20% ethyl acetate in hexane) as an off-white solid. Two equivalents of D-β-thienylalanine piperonyl amide hydrochloride are added to a solution of one equivalent of 2-imidazolyl-4,6-dichloropyrimidine (the compound of formula (Villa)) and three equivalents of Hünig's base (diisopropylethylamine) in THF . After the reaction is complete, all volatiles are removed and the product is isolated (the compound of formula (Iaa)).

A specific example of the synthesis is given as applied to sarcosine piperonyl amide hydrochloride: Isobutyl chloroformate (226 μL, 1.73 mmol) is added to a solution of N-Boc sarcosine (1.73 mmol) and N-methylmorpholine (192 μL, 1.73 mmoles) in THF. After two minutes, piperonylamine (216 ml, 1.73 mmol) is added and the mixture is allowed to warm to room temperature. After thirty minutes, the reaction mixture is passed through a pad of Celite and all volatiles are removed under reduced pressure to provide N-Boc sarcosine piperonyl amide (531 mg, 95%) as a white solid. XH NMR: (CDC13) d 2.41 (s, 3H), 3.28 (s, 2H), 4.39 (d, 2H), 5.95 (s, 2H), 6.80 (m, 3H), 7.43 (s broad, 1H), 9.04 (broad s, 1H). N-Boc sarcosine piperonilamide (500 mg, 1.54 mmol) in methanol (10 ml) is treated with acetyl chloride (1 ml).

After 45 minutes, all volatiles are removed under reduced pressure to provide the sarcosine piperonyl amide hydrochloride (395 mg, quantitative) as a sticky solid. Imidazole (9.5 g, 140 mmol) is added in one portion to a solution of trichloropyrimidine (24.7 g, 135 mmol) and triethylamine (30 mL, 216 mmol) in THF (500 mL). After 16 h, the reaction mixture is poured into saturated aqueous ammonium chloride and extracted three times with ethyl acetate. The combined organic layers are washed with brine and dried over MgSO .. The reaction mixture is filtered and all volatile fractions are removed under reduced pressure. 2-Imidazolyl-4,6-dichloropyrimidine (the compound of the formula (Villa)) (9.61 g, 33%) is isolated by flash chromatography (20% ethyl acetate in hexane) as an off-white solid. X H NMR: (CDC13) d 7.13 (s, 1 H), 7.25 (s, 1 H), 7.76 (s, 1 H), 8.50 (s, 1 H). Sarcosine piperonyl amide hydrochloride (50 mg, 0.19 mmol) is added to a solution of 2-imidazolyl-4,6-dichloropyrimidine (Villa) (20 mg, 0.093 mmol) and Hünig's base (50 μl, 0.29 mmol) in THF ( 1 ml). After 16 h, all volatile fractions are removed and the product is isolated as a waxy solid (29 mg, 78%). XH NMR: (CDC13) d 3.2 (s, 3H), 4.25 (s, 2H), 4.38 (s, 2H), 5.88 (s, 2H), 6.30 (s broad, 1H), 6.42 (s broad, 2 H) ), 6.65 (m, 3 H), 7.05 (s, 1H), 8.40 (s, 1 H). Another specific example of the synthesis of vun compound of (XIc) is provided: Boc-pyrrolidine (3.0 g, 17.5 mmol) is dissolved in ether (35 ml) and tetraethylethylenediamine (TMEDA) (2.03 g, 17.5 mmol), cooled at -78 ° C and s-butyllithium (1.3 M, 13.5 ml, 18 mmol) is added. After stirring for 1 hour, allyl bromide in ether (5 ml) is added. After warming to room temperature, the reaction is suspended with water and the organic layer is separated. The organic layer is washed with a 1 M solution of NaHP04 and water, and then dried over MgSO4. The solvent is removed in vacuo and the residue is purified by chromatography on silica gel (hexanes / ethyl acetate (9: 1) to give the olefin (0.50 g, 14%, XH NMR: (CDC13) d 5.56-5.85 (m, 1H), 5.00-5.20 (m, 2 H), 3.70-3.90 (m, 1H), 3.20-3.45 (m, 2H), 2.35-2.60 (M, 1H) 2.00-2.20 (m, 1H) ), 1.60-2.00 (m, 4H), 1.45 (s, 9H)). Olefin is dissolved (500 mg, 2.37 mmol), 5-bromo-l, 3-benzodioxolane (476 mg, 2.37 mmol), triethylamine ( 478 mg, 4.74 mmol), tri-o-tolylphosphine (96 mg, 0.31 mmol) and Pd (OAc), (26 mg, 0.12 mmol) in CH3CN, reflux overnight under argon, add 1 additional equivalent (476 mg) of the bromide and Pd (OAC) 2 (52 mg, 0.24 mmol), and the reflux continues for 4.5 hours The reaction is filtered and the solvent is evaporated The residue is taken up in ether and washed successively with water , NaH2P04 1 M, water and brine After drying, the solvent is removed and the product is purified by chromatography (silica gel, hexane: acetamide ethyl acetate, 4: 1) to provide 152 mg (19%) of the Boc-protected [(1,3-benzodiox-5-yl) prop-2-enyl] pyrrolidine (XH NMR: (CDC13) d 6.90 ( s, 1 H), 6.70-6.80 (m. 2H), 6.35 (d, 1H). 3.80-3.95 (m, 1H), 3.25-3.50 (m, 2H), 2.45-2.70 (m, 1H), 2.20-2.35 (M, 1H), 1.70-2.00 (M, 4H), 1.45 (s, 9H) )). The Boc group is removed under standard or conventional conditions. Another specific embodiment of the generic synthesis as applied to a compound of the invention is as follows: To butyl alcohol (3 ml) is added 2-fluoro-4-chloropurine (41 mg, 0.24 mmol), N- [(1, 3-benzodioxol-5-yl) methyl] piperidin-2-acetamide (66 mg, 0.24 mmol) and Hünig's base (diisopropylethylamine) (0.042 ml, 0.24 mmol). After stirring at 90 ° C for 6 hours, the reaction is diluted with ethyl acetate. The organic material is washed with NH 4 Cl and brine, dried (MgSO 4) and the solvent removed in vacuo. Chromatography of the residue (CH2Cl2 / MeOH, 10/1) gives 42 mg of fluoropurine. Fluoropurine (18.9 mg, 0.046 mmol) is dissolved in DMSO and reacted with TMS-imidazole (0.10 g, 0.66 mmol) and CsF (61 mg, 0.40 mmol). After shaking 130 ° C for 72 hours, the reaction is diluted with ethyl acetate and washed with saturated NH 4 Cl and brine. The organic layer is dried (MgSO 4), the solvent is removed in vacuo and the residue is subjected to chromatography (CH 2 Cl 2 / MeOH, 19/1) to provide 12 mg of N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) yl) purin-6-yl] piperidin-2-acetamide. Another specific example of synthesis is provided: To THF (10 ml) is added cyanuric chloride (158 mg, 0.85 mmol), N - [(1,3-benzodioxol-5-yl) methyl] piperidin-2-acetamide (47 mg , 0.17 mmole) and imidazole (58 mg, 0.85 mmole).

After stirring for 12 hours, the reaction is diluted with ethyl acetate. The organic material is washed with saturated NH4C1 and brine, dried (MgSO4) and the solvent removed in vacuo. Chromatography of the residue (hexanes / ethyl acetates 4/1) gives 60 mg of dichlorotriazine. Dichlorotriazine 5 (20 mg, 0.047 mmol) is dissolved in THF and reacted with TMS-imidazole (0.009 ml, 0.06 mmol) and CsF (11 mg, 0.07 mmol) at 0 ° C. After warming to room temperature and stirring for 4 hours, the reaction is diluted with ethyl acetate and washed with saturated NH 4 Cl, water and brine. The organic layer is dried (MgSO.sub.4), the solvent is removed in vacuo and the residue is subjected to chromatography (ethyl acetate / hexanes / MeOH, 4/4/1) to yield 6.5 mg of N- [(l, 3 -benzodioxol-5-yl) methyl] -1- [(3-chloro-5- (lH-imidazol-1-yl) triazin-2-yl] piperidin-2-acetamide Another specific example of synthesis is provided: A a solution of indole-5-carboxylic acid (0.50 g, 3. 1 mmole) in MeOH (25 ml) is added trimethylsilyldiazomethane until no gas production is observed. The solution is concentrated, dissolved in CH2C12 and washed with saturated NaHCO3 and brine. The organic layer is dried (MgSO.sub.4) and the solvent is removed in vacuo to provide 0.54 g of the ester (1ti NMR: (CDC13) d 3.95 (s, 3H), 6.63 (s, 1H), 7.25 (m, 1H), 7.40 (d, 1H), 7.95 (d, 1H), 8.25-8.4 (broad s, 1H), 8.45 (s, 1H)). The ester (100 mg, 0.58 mmol) is dissolved in DMF (10 ml) and 4-chloro-2-imidazol-1-ylpyrimidine (113 mg, 0.63 mmol) is added. After heating at 60 ° C for 18 hours, the solvent is removed in va cuo, the residue is dissolved in CH2C12 and washed with NaHCO3 and brine. The organic layer is dried (MgSO 4), the solvent is removed in vacuo and the residue is subjected to chromatography (CH 2 Cl 2 / MeOH, 19/1) to provide 68 mg, (37%) of the pyrimidine (XH NMR: (CDC13 ) d 3.95 (s, 3H), 6.90 (s, 1H), 7.25 (m, 2H), 7.80 (m, 1H), 7.95 (s, 1H), 8.10 (d, 1H), 8.4 (s, 1H) , 8.50 (d, 1H), 8.70 (m, 2H)). The pyrimidine is dissolved in THF / water (1/1) and LiOH (6 mg, 0.21 mmol) is added. After heating at 60 ° C for 3 h, the solvent is removed in va cuo and acidified with methanolic HCl. The solvent is removed in vacuo, dissolved in DMF and treated with HATU 42 mg, 0.11 mmol), DIEA (37 mg, 0.21 mmol) and piperonyl amine (26 ml, 0.21 mmol). After stirring for 18 hours, the solvent is removed in vacuo, the residue is dissolved in CH2C12 and washed with saturated NaHCO3 and brine. The organic layer is dried (MgSO 4), the solvent is removed in vacuo and the residue is subjected to chromatography (CH 2 Cl 2 / MeOH, 19/1) to provide 2 mg (4%) of N- [(1,3-benzodioxol- 5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] indole-6-carboxamide; XH NMR: (CDC13) d 3.75 (s, 2H), 5.95 (s, 2H), 6.80-6.90 (m, 2H), 7.05-7.15 (m, 2H), 7.25 (m, 2H), 7.75-7.85 ( m, 2H). 8.00 (s, 2H), 8.50-8.60 (m, 2H). 8.70-8.80 (m, 1H); MS: 439.2 M + H) X Another specific embodiment of the generic synthesis as applied to a compound of the invention is N- [(1,3-benzodioxol-5-yl) ethyl] -l- [2- (lH- imide zol-1-yl) pyrimidin-4-yl] pyrrole-2-carboxamide [MS: (403.2 M + H) +], which is prepared in a manner similar to that described above for N- [(1 , 3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] indole-6-carboxamide.

Reaction scheme 3 below shows a method for preparing the compounds of the invention wherein U is CR5 (wherein R6 is hydrogen) and X, Y and Z are CR19 (wherein R19 is hydrogen): Reaction scheme 3 The above synthesis can be carried out as follows: To benzene (20 ml) is added 1- (3-aminophenyl) imidazole (755 mg, 4.7 mmol), 7-chloro-3-oxoheptanoic acid ethyl ester (982 mg, 4.7 mmoles), Na2HP04 (667 mg, 4.7 mmol), I2 (60 mg, 0.23 mmol) and molecular sieves of 4Á (500 mg). After refluxing for 6 hours, more I, (60 mg) is added. After stirring for 16 hours, the reaction is filtered, the solvent is removed in vacuo and the residues are chromatographed (CH2Cl2MeOH, 98/2) to give 120 mg, (8%) of 1- [3- (lH -imidazol-l-yl) phenyl] piperidin-2-acrylic acid ester (? RMN: (CDC13) d 7.85 (s, 1H), 7.05-7.50 (m, 6H), 4.80 (s, 1H), 4.15 (c, 2H), 3.45 (t, 2H), 2.4 (t, 2H0, 1.5-1.8 (m, 6H, 1.30 (t, 3H)) This ester (120 mg, 0.38 mmol) is dissolved in MeOH ( 20 ml) and reacted with 10% Pd / C (60 mg) and 1 atm of H. After reacting for 60 hours, the reaction is filtered, the solvent is removed in vacuo and the residue is chromatographed. (ethyl acetate / hexanes, 1/1) to provide 24 mg of 1- [3- (1H-imidazol-1-yl) phenyl] piperidin-2-acetic acid ethyl ester (compound of formula (XV)). This ester (24 mg, 0.076 mmol) is dissolved in 5% methanolic NaOH, after stirring for 16 hours, the reaction is acidified with methane HCl. The solvent is removed in vacuo and the residue is dissolved in DMF. Piperonyl amine (1 equivalent) base of Hunig (2 equivalents) and HATU (1 equivalent) are added. After completion of the reaction, the reaction mixture is partitioned with water and ethyl acetate. The organic layer is separated, washed with water and dried. The solvent is removed in vacuo and the residue is subjected to chromatography (ethyl acetate / MeOH, 98/2) to give 6 mg of the compound of formula (Ibb), N- [(1,3-benzodioxol-5-yl) ) methyl] -1- [3- (lH-imidazol-1-yl) phenyl] piperidin-2-acetamide:: H NMR: (CDC13) d 7.80 (s, 1H), 7.10-7.30 (m, 4H), 6.50-6.70 (m, 5H), 5.90 (s, 2H), 4.20-4.35 (m, 2H), 3.85 (s broad, 1H), 3.50 (t, 2H), 2.95 (d, 1H), 2.35-2.55 (m, 2H), 1.4-1.9 (m, 6H); MS: (419 M + H] X The following Reaction Scheme 4, shows a method for preparing compounds of the invention wherein A is -OR1: Reaction Scheme 4 10 25 The above synthesis can be carried out as follows: To DMF (100 ml) is added 4-chloro-2-imidazol-1-pyrimidine (0.50 g), 2.77 mmole), 2-piperidinetanol (0.359 g, 277 mmole) , and Hünig base (0.536 g, 4.15 mmol). After heating up 80 ° C for 5 hours, the solvent is removed in vacuo and the residue is subjected to chromatography (CH2Cl2 / MeOH, 19/1) to provide 349 mg (46%) of 1- [(1H-imidazole-1) il) pyrimidin-4-yl] piperidin-2-ethanol (the compound of formula XVI)), (XH NMR: (CDC13) d 8.65 (s, 2H), 8.11 (d, 1H), 7.82 (t, 1H) , 7.11 (d, 1H), 6.44 (d, 1H), 3.60 (m, 2H), 3.03 (m, 1H), 1.77 (m); MS: 274 (M + H) +). To a solution of 1- [(lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-ethanol (25 mg, 0.092 mmol) dissolved in DMF (5 ml) is added NaH (60% dispersion in oil , 5.5 mg, 0.14 mmol) followed by piperonyl chloride (17 mg, 5 0.10 mmol) and t-butylammonium chloride. After stirring for 16 hours at 80 ° C, the solvent is removed in vacuo and the residue is partitioned with saturated NH 4 Cl and CH 2 Cl. The organic layer is separated, dried (MgSO 4), the solvent is removed in vacuo and the residue is subjected to chromatography (CH 2 Cl 2 / MeOH, 19/1) to provide 13 mg (35%) of 4- [2- [[ (1,3-benzodioxol-5-yl) methoxy] ethyl] piperidin-1-yl] -2- (1 H -imidazol-1-yl) pyrimidine (the compound of the formula (Ice)); XH NMR: (CDC13) d 8.52 (s, 1H), 8.05 (d, 1H), 7.80 (s, 1H), 7.09 (s, 1H), 6.73 (m, 3H), 6.45 (d, 1H), 5.93 (s, 2H), 4.30 (s, 2H), 3.45 (m, 2H), 2.95 (m, 1H),, 1.55 (m); MS: 408.7 (M + H) X The compounds of formula (XVI) can be used to prepare other compounds of the invention as shown below in Reaction Scheme 5 wherein Rlb is hydrogen or -CH 3, Ms is mesyl and Ac is acetyl: Reaction Scheme 5 (xvp) The above synthesis can be carried out as follows: To a solution of 1- [(lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-ethanol (the compound of formula (XVI)) (236 mg , 0.86 mmol) and methanesulfonyl chloride (99 mg, 0.87 mmol) dissolved in CH2C12 (20 ml) was added TEA (87.5 mg, 0.87 mmol). After stirring for 16 hours at 0 ° C, methanesulfonyl chloride (99 mg, 0.87 mmol) and TEA (87.5 mg, 0.87 mmol) are added and the solution is warmed to room temperature. After stirring for 1 hour, the solution is washed with saturated NH 4 Cl and brine, dried (MgSO 4) and the solvent removed in vacuo to provide 276 mg (91%) of the compound of formula (XVII). { l NMR: (CDC13) d 8.72 (s, 1H), 8.15 (d, 1H), 7.89 (s, 1H), 7.18 (s, 1H), 6.46 (d, 1H), 4.24 (m, 3H), 2.95 (s, 3H), 2.18 (m, 6H), 1.76 (m). MS: 352.5 (M + H) +). A solution of the compound of formula (XVII) (100 mg, 0.28 mmol) and a compound of formula (XVIII) (429 mg, 2.84 mmol) dissolved in CH2C12 (7.5 ml) is stirred for 16 hours and then DMF (7.5 ml). After stirring for 2 hours, the solvent is removed in vacuo and the residue is partitioned with saturated NH4C1 and CH2C12. The organic layer is separated, washed with brine, dried (MgSO.sub.4), the solvent is removed in vacuo and the residue is chromatographed.

(CH2Cl2 / MeOH, 19/1) to provide 6.6 mg (21%) of N - [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidine -4-yl] piperidin-2-ethanamine (the compound of the formula (reads)): X H NMR: (CDC 13) δ 8.50 (s, 1 H). 8.08 (d, 1H), 7.77 (s, 1H), 7.08 (s, 1H), 6.66 (m, 3H), 6.43 (d, 1H), 5.91 (s, 2H), 3.60 (d, 2H), 3.00 (m, 1H), 2.57 (m, 2H), 2.02 (m, 1H), 1.65 (m), MS: 407.8 (M + H) XA THF (3 ml) is added N- [(1,3-benzodioxol -5-yl) methyl] -l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-ethanamine (8 mg, 0.03 mmol), Hünig's base (8 mg, 0.06 mmol) ) and acetic anhydride (4 mg, 0.04 mmol). After stirring for 16 hours, the solvent is removed in vacuo and the residue is subjected to chromatography (CH 2 Cl 2 / MeOH, 19/1) to give 8 mg (60%) of N-acetyl-N- [(1, 3 -benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-ethanamine (the compound of the formula Igg)): XH NMR: (CDC13) d 8.48 (s, 1H), 8.08 (d, 1H), 7.76 (s, 1H), 7.09 (s, 1H), 6.66 (m, 3H), 6.33 (m, 1H), 5.94 (s, 1H), 5.91 (s, 1H), 4.43 (m, 3H), 3.40 (m, 2H), 2.11 (d, 3H). 1.14 (m); MS: 450.0 (M + H) X Alternatively, N - [(1,3-benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) is added to THF (3 ml). pyrimidin-4-yl] piperidin-2-ethanamine (8 mg, 0.03 mmol), Hünig's base (8 mg, 0.06 mmol) and methanesulfonyl chloride (4.5 mg, 0.04 mmol). After stirring for 16 hours, the solvent is removed in vacuo and the residue is subjected to chromatography (CH2Cl2 / MeOH.19 / 1) to provide 7 mg (51%) of N - [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidine -4-yl] - N- (methylsulfonyl) piperidin-2-ethanamine (the compound of the formula (Iff)); 2 H NMR: (CDC13) d 8.10 (s, 1 H), 7.78 (d, 1 H), 7.13 (s, 1 H), 6.82 (s, 1 H), 6.72 (s, 2 H), 6.30 (d, 1 H), 5.94 (s, 2H), 4.23 (m, 3H), 3.20 (m, 2H), 2.80 (s, 3H), 1.14 (m); MS: 485.7 (M + H)? A DMF (5 ml) is added a compound of formula (XVII) (50 mg, 0.14 mmol), Hünig base (28 mg, 0.21 mmol), and N-methyl piperonylamine (28 mg , 0.17 mmole). After stirring at 80 ° C for 16 hours, the solvent is removed in vacuo and the residue partitioned with saturated NH 4 Cl and CH 2 C 12. The organic layer is separated, washed with brine, dried (MgSO 4), the solvent is removed in vacuo and the residue is partitioned with ethyl acetate and water. The organic layer is separated, washed with brine, dried (MgSO.sub.4), the solvent is removed in vacuo and the residue is subjected to chromatography (ethyl acetate / MeOH, 19/1) to give 7 mg (12%). of N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N-methylpiperidin-2-ethanamine (the compound of formula (Idd)); X H NMR: (CDC13) d 8.53 (s, 1H), 8.07 (d, 1H), 7.80 (s, 1H), 7.10 (s, 1H), 6.78 (s, 1H), 6.69 (m, 2H). 6.43 (d, 1H), 5.92 (s, 2H), 3.40 (m, 2H). 2.97 (m, 1H), 1.80 (m); MS: 422.0 (M + H) X Reaction scheme 6 shows another method for preparing compounds of the invention wherein V is C (R) H: Reaction Scheme 6 The above synthesis can be carried out as follows: To a solution of LDA (1.28 g, 12 mmol) in THF (30 ml) at -78 ° C is added 2,4-dichloro-6-methylpyrimidine (1.96 g, 12 g). mmoles) in THF (15 ml). After stirring for 15 minutes, 3, 3-dimethylallyl bromide (1.79 g, 12 mmol) in THF (5 ml) is added dropwise. After the reaction is warmed to room temperature, water and ethyl acetate are added. The organic layer is separated, the solvent is removed in vacuo and the residue is subjected to chromatography (ethyl acetate / hexane, 1/19) to give 2.06 g (74%) of 2,4-dichloro-6- (4). -methyl-3-pentenyl) pyrimidine (XH NMR: (CDC13) d 7.15 (s, 1H), 5.10 (t, 1H), 2.80 (t, 2H), 2.45 (m, 2H), 1.70 (s, 3H) , 1.55 (s, 3H)). To a solution of NaI04 (17 g, 51 mmol) and KMn04 (251 mg, 1.59 mmol) in water is added K2C03 (1.29 g, 9.38 mmol) and 2,4-dichloro-6- (4-methyl-3-pentenyl). ) pyrimidine (2.06 g, 8.9 mmol) in t-butanol. After stirring for 16 hours, the reaction is acidified to pH 3 and extracted with ethyl acetate. The organic layer is extracted with aqueous NaHCO3. The aqueous layer is acidified to pH 3 and extracted with ethyl acetate. The organic layer is dried and the solvent removed in vacuo to provide 980 mg of 3- (2,4-dichloropyrimidin-6-yl) propionic acid (the compound of formula (XIX)), lti NMR: (CDC13) d 7.30 s, 1H), 3.05 (t, 2H), 2.90 (t, 2H). The acid is coupled to piperonylamine under standard conditions with isobutyl chloroformate and N-methylmorpholine to provide the compound of formula (XX). Imidazole is added under standard conditions (1-trimethylsilylimidazole and CsF in DMF at 60 ° C) to provide N- [(1,3-benzodioxol-5-yl) ethyl] -6-chloro- 2- (1H-imidazole-1) -yl) pyrimidine-4-propionamide (the compound of formula (Ihh)): MS: 386 (M + H) X The generic synthesis in solid phase can be conceptualized as the generic synthesis of reaction scheme 1 in which R1 has has been replaced by a separable linkage to a derivatized polymer resin. At the end of the Synthesis Scheme, the resin is separated and R1 becomes hydrogen. The solid phase synthesis scheme is illustrated in Reaction Scheme 7 as applied to a specific example, as in the foregoing, of a piperonyl amide, but in this case the amino acid is piperazin-2-acetic acid: Reaction Scheme 7 (XXV) Continuation of Reaction Scheme 7 vulnerability ation In solid phase synthesis, the group which becomes R1 is bound to the resin through a separable linkage, such as the 2-nitrobenzyl residue, which can be separated photolytically. In the Example shown, the piperonylamine (see above) has been protected with Boc and reacted with 4- (bromomethyl) -3-nitrobenzoic acid to produce the Boc-protected compound of formula (XXI), which is then attached to a free amine of the synthetic support with amino functionality, derivatized with lysine. In this case, a cross-linked polystyrene grafted with polyethylene glycol, cross-linked DVB 1% polystyrene or crosslinked polydimethylacrylamide is suspended in a polar aprotic solvent such as methylene chloride, DMF or THF. An excess of the suitably protected linker synthon is added to the suspended support followed by a coupling reagent such as diisopropylcarbodiimide (DIC), dicyclohexylcarbodiimide (DCC), bis (2-oxo-3-oxazolidinyl) phosphinic (BOP) or O- (7) chloride. α-azabenzotriazol-1-yl) -1, 1, 3, 3-tetramethyluronium-hexafluorophosphate (HATU) and optionally an acylation catalyst such as dimethylaminopyridine (DMAP) or hydroxybenzotriazole (HOBT). The mixture is stirred at room temperature for 1 to 24 hours or until the reaction is complete judging by a ninhydrin test. The resin is washed with an appropriate solvent or solvents several times to remove excess reagents and by-products to provide the resin compound of formula (XXII). The resin compound of formula (XXII) is deprotected to release the compound of formula (XXIII), which is then suspended in a polar aprotic solvent such as methylene chloride or DMF. An excess of an appropriately protected compound of formula (XXIV) is added followed by a coupling agent such as HATU, BOP or DIC with the optional addition of an acylation catalyst such as DMAP or HOBT. Alternatively, an excess of the activated form of the compound of formula (XXIV) such as the symmetric anhydride of acyl fluoride can be added to the resin. The mixture is stirred for 1 to 24 hours at room temperature and then washed several times with an appropriate solvent or with solvents to remove excess reagents and by-products to provide the resin compound of formula (XXV). The resin compound of formula (XXV) is deprotected to release the compound of formula (XXVI), which is then suspended in a polar aprotic solvent such as DMF or THF. An excess of the appropriate compound of formula (Vlllb) is added followed by an excess of a base such as triethylamine or diisopropylethylamine. The mixture is stirred and heated at 50-100 ° C for 1 to 24 hours, then cooled and washed several times with a suitable solvent to remove excess reagents and by-products to provide the resin compound of formula (IXaa) . The resin compound of the formula (IXaa) is optionally treated to release the protected functionality incorporated as part of a synthon to produce the compound of the formula (III). For those compounds in which the piperazine substitution pattern is reversed (for example, in Examples 95 to 102 below), the procedure of the preceding paragraph may be modified slightly. The resin compound of formula (XXV) is deprotected with piperidine to liberate an amine and then dissolved or suspended in an inert solvent, such as methylene dichloride. An excess of a suitably protected acid that will provide the R5 is added, followed by a coupling agent such as HATU, BOP or DIC, with the optional addition of an acylation catalyst such as DMAP or HOBT. Alternatively, an excess of an activated form of the acid, such as the symmetrical anhydride of acyl fluoride, may be added to the resin. The mixture is stirred for 1 to 24 hours at room temperature and then washed several times with an appropriate solvent or with solvents to remove excess reagents. The product is suspended in a polar aprotic solvent, such as DMF or THF. An excess of the appropriate compound of formula (Vlllb) is added followed by an excess of a base such as triethylamine or diisopropylethylamine. The mixture is stirred and heated at 50-100 ° C for 1 to 24 hours, then cooled and washed several times with an appropriate solvent to remove excess reagents and by-products to provide the resin compounds analogous to the resin compound. of formula (IXaa) but having pyrimidine bound to the piperazineacetic acid in the 4-position. The resin compound analogous to the resin compound of the formula (IXaa) is then suspended in a protic solvent such as methanol or acetonitrile-water and stirred and photolysis to separate the product from the resin. Filtration and evaporation of the filtrate provides the untreated product, which is then purified and characterized by standard techniques. In a specific example, 1.57 g of TentaGel resin with amino functionality (0.80 mmol) in 20 ml of methylene chloride is suspended and treated with 1.05 g of linker acid (2.4 mmoles), 0.50 ml of DIC (3.2 mmoles) and mg of DMAP (0.16 mmol). The mixture is stirred at room temperature for 20 hours and then washed with methylene chloride ten times to provide a resin compound of formula (XXII). The resin compound of formula (XXII) is treated with 50% trifluoroacetic acid (TFA) in methylene chloride at room temperature for 2 hours and then washed with methylene chloride ten times, 15% triethylamine in methylene chloride for 10 hours. minutes and again in methylene chloride for 5 times. The deprotected resin compound of formula (XXIII) is then suspended in 12 ml of methylene chloride and treated with 1444 g of the compound of formula (XXIV) (3.2 mmoles), 1,216 g of HATU (3.2 mmoles) and 1.3 ml of diisopropylethylamine (7.2 mmoles). The mixture is stirred for 16 hours at room temperature and then washed five times to provide the resin compound of formula (XXV). Fmoc is removed by treatment with 30% piperidine in DMF and 777 mg of the resulting resin bound compound of formula (XXVI) (0.35 mmol) then reacted with 320 mg of 2-imidazolyl-4-chloropyrimidine (the compound of formula XVIIIb )) in the presence of 0.61 ml of diisopropylethylamine (3.5 mmoles) in 12 ml of DMF at 80 ° C for 15 hours and then cooled to room temperature and washed with DMF and methylene chloride to provide the resin compound of formula ( IXaa). The final product is separated from the resin by photolysis in methanol (MeOH) for 17 hours to provide 54.6 mg of product, a compound of formula (III) (31%). The untreated product is purified by flash chromatography (eluting with 4: 4: 1 ethyl acetate: hexanes: MeOH). The Boc-protected amine product is treated with 3 ml of 30% TFA-methylene chloride for 1 hour and dried in vacuo to provide a quantitative amount of the product. The piperazine acetic acid compound of formula (XXIV) used in the above synthesis and many others in this application, are synthesized as follows: twelve milliliters (50 mmol) of N, N'-dibenzylethylene diamine, 14 ml (100 mmol) are combined. ) of Et3N and 250 ml of toluene at 0 ° C, and 7 ml (50 mmol) of methyl 4-bromocrotonate (7 ml, 50 mmol) are added. The reaction is warmed slowly to room temperature, stirred for 24 hours, filtered, concentrated in vacuo to a residue and treated with 10% aqueous HCl (300 ml). The mixture is filtered again and the filtrate is washed with ethyl acetate (2 x 100 ml). The filtrate is made basic with K2C03 and extracted with ethyl acetate (3 x 150 ml). The combined extracts are washed with brine, dried over MgSO4 and concentrated in vacuo to provide 13.7 g of 1,4-dibenzylpiperazine-2-methyl acetate. XH NMR: (CDC13) d 2.28-2.50 (m, 4H), 2.5-2.75 (m, 4H), 3.1 (broad s, 1H), 3.42 (d, 2H), 3.52 (d, 1H), 3.6 (s) , 3H), 3.75 (d, 1H), 7.15-7.35 (m, 1H). The 13.7 g (40 mmol) of 1,4-dibenzylpiperazine-2-methyl acetate, 150 ml of MeOH, 50 ml of 1 N HCl (aqueous) and 3 g of 10% Pd / C are combined and hydrogenated with H2 (3.5 kg / cm2 (50 psi)) for 24 hours. The reaction is filtered, the filtrate is concentrated in vacuo to remove most of the MeOH and the residue is made basic with K2C03 until pH = 9-10, and 9.8 g (40 mmoles) of BOC- are added slowly at 0 ° C. ON. The reaction is stirred at 0 ° for 1 hour, allowed to warm to room temperature, stirred for 2 hours and extracted with ethyl acetate (2 x 200 ml). The combined extracts are left with 50 ml of 10% HCl (aqueous). The aqueous layer is washed with ethyl acetate, made basic with MgSO 4 and extracted three times with ethyl acetate. The combined organic layers are washed with brine, dried over MgSO4 and concentrated in vacuo to provide 7.89 g of methyl 4-Boc-piperazin-2-acetate; XH NMR: (CDC13) d 1.4 (s, 9H), 2.31 (dd, 1H), 2.37 (dd, 1H), 2.55 (broad, 1H), 2.69-3.02 (m, 4H), 3.75 (s, 3H) , 3.88 (broad, 2H). A portion of the product of methyl 4-Boc-piperazin-2-acetate (5.2 mg, 20 mmol) from the previous step is combined with 60 ml of THF and 60 ml of 1 N NaOH (aqueous) and stirred at room temperature for 6 hours to saponify the methyl ester. The reaction is cooled to 0 ° C, adjusted to pH 9-10 with 10% HCl (aqueous) and 5.2 g (20 mmoles) of FMOC-C1 are added. The reaction is stirred at room temperature for 6 hours (adding 1 N NaOH (aqueous) to maintain pH = 9-10) 1 hour, and then acidified with 10% HCl until pH = 1. The reaction is extracted twice, The combined organic layers are washed with brine, dried over MgSO4 and concentrated in vacuo to provide 8.55 g of the desired 4-Boc-1-Fmoc-piperazine-2-acetic acid (the compound of formula (XXIV)); XH NMR: (CDC13) d 1.4 (s, 9H), 2.5-3.0 (m, 5H), 3.9-4.2 (m, 6H), 4.5 (m, 1H), 7-25 (t, 4H), 7.32 ( t, 4H), 7.48 (d, 4H), 7.75 (d, 4H). In cases where 4-Boc-1-Fmoc-piperazine-2-acetic acid (the compound of formula (XXIV)) is replaced by 4-Boc-1-Fmoc-piperazine-2-carboxylic acid, the material Initial is prepared by dissolving 5.25 g (25.85 mmoles) of 2-piperazinecarboxylic acid-2HC1 in 160 ml of 1: 1 dioxane / H20, and adjusting the pH to 11 with 50% NaOH (aqueous). A solution of 7.21 g (29.28 mmoles) of BOC-ON in 40 ml of dioxane is added slowly (in portions) while maintaining the pH in 11 with 50% NaOH (aqueous) during the addition. The reaction is stirred at room temperature for 5 hours, then cooled to 0 ° C and adjusted to pH 9.5, with 50% NaOH (aqueous). A solution of 7.34 g (28.37 mmoles) of Fmoc-Cl in 40 ml of dioxane is added slowly (in portions), maintaining a pH of 9.5 during the addition of 50% NaOH (aqueous). The mixture is warmed to room temperature, stirred for 20 hours, washed with ethyl ether (3 x 150 ml), adjusted to pH = 2-3 with 6 N HCl (aqueous) and extracted with toluene (3 x 150). ml). The combined extracts are dried over Na 2 SO 4, concentrated in vacuo to a volume of 150 ml and cooled to -20 ° C overnight. The resulting solids are separated by filtration, washed with hexane and dried in vacuo to provide 5.4 g of the desired 4-Boc-1-Fmoc-piperazine-2-carboxylic acid. Alternatively, 4-Boc-morpholine-3-carboxylic acid can be prepared in the following manner, which can be substituted for the compound of formula (XXIV) in Reaction Scheme 7 above to prepare other compounds of the invention. To a solution of the 4-phenylmethylmorpholin-5-one-3-carboxylic acid methyl ester (5.1 g, 20.5 mmol) in 100 mL of THF is added borane / DMS (10 M, 2.6 mL) slowly while cooling to 0 °. C. The solution is allowed to warm to room temperature and is stirred for 18 hours. Water (100 ml) is then added and the mixture is extracted with ethyl acetate. The organic layers are dried over MgSO4 and concentrated. The resulting oil is purified on a column of silica gel eluted with ethyl acetate: hexanes 3: 7 to give the morpholine (3.0 g, 84%). The morpholine (3.0 g, 12.75 mmol) is dissolved in 50 ml of MeOH and 10% Pd / C (10 mg) is added. The mixture is stirred at room temperature under an atmosphere of H2 for 16 hours. The mixture is then filtered through Celite and concentrated. The resulting oil is dissolved in CH2C1, (25 ml) and di-t-butyldicarbonate (2.8 g, 12.75 mmol) is added. After stirring for 4 hours, the mixture is concentrated and taken up in CH2C12 and washed with water, saturated NaHCO3 and brine. The organic layer is dried over MgSO4 and concentrated to provide 2.8 g (89%) of the ester. The ester is dissolved in MeOH (30 ml) and NaOH (1.4 g, 35 mmol) is added. After stirring for 4 hours at reflux, the solution is concentrated, acidified with 1 N HCl and extracted with CH2C12. The organic layer is dried (MgSO 4) and concentrated to give 4-Boc-morpholine-3-carboxylic acid as a white solid (2.4 g., 90%). X H NMR: (CDC13) d 1.40 (m, 9H), 3.20-350 (m, 2H), 3.70 (m, 2H), 3.90 (m, 1H), 4.30-4.65 (m, 2H). The l-Boc-perhydroazepin-2-acetic acid can also be substituted by the compound of formula (XXIV) in Reaction Scheme 7 and can be prepared as follows: N-Boc-perhydroazepine (1.06 g, 5.16) is treated mmoles) in ether with TMEDA (715 mg, 6.16 mmol) followed by sec-butyllithium (1.3 M, 4.74 ml, 6.16 mmol) at -78 ° C. The reaction is warmed slowly to -40 ° C, stirred for 1 hour, cooled to -78 ° C and treated with a solution of 3,3-dimethylallyl bromide (918 mg, 6.16 mmol) in ether. After warming to room temperature and suspending with water, the organic layer is washed with water, 1 M NaH2P04, water and brine. After drying (MgSO 4) the solvent is removed and the product is purified by chromatography (silica gel, hexane: ethyl acetate, 95: 5), to give the olefin (300 mg, 21%, XH NMR: (CDC13) d 5.05-5.20 (m, 1H), 3.55-3.80 (m, 2H), 2.60-2.75 (m, 1H), 1.90-2.20 (M, 3H), 1.10-1.80 (m, 22H). To a solution of NaI04 (2.17 g, 10.2 mmol) and KMn04 (32 mg, 0.2 mmol) in 45 ml of water is added K2C03 (162 mg, 1.18 mmol) and the olefin (300 mg, 1.12 mmol) dissolved in t- butanol (11 ml). After stirring for 3 days, the reaction is acidified to pH 3 and extracted with ethyl acetate. The organic layer is washed with water and brine, dried (MgSO.sub.4) and the solvent removed in vacuo to give l-Boc-perhydroazepine-2-acetic acid (250 mg, 87%):? Ti NMR: (CDC13) d 4.20-4.45 (m, 1H), 3.55-3.80 (m, 1H), 2.00-2.80 (m, 4H), 1.10-1.80 (m, 16H). 4-Boc-morpholine-3-acetic acid may also be substituted for the compound of formula (XXIV) in Reaction Scheme 7, and may be prepared as follows from the methyl ester of 4-benzylmorpholin-3-acid. acetic acid (Brown, GR: Foubister, AJ, Stribling, DJ Chem. Soc. Porkin Trans. 1 (1987), p.547). After hydrogenolysis (Pd (OH) 2.H2) of the benzyl group, the N-Boc derivative is prepared by treatment with di-t-butyl dicarbonate and the ethyl ester is hydrolyzed by an aqueous base to provide the 4-Boc acid. -morpholin-3-acetic. The l-Boc-pyrrolidin-2-propionic acid can also be substituted by the compound of formula (XXIV) in Reaction Scheme 7 and can be prepared in the following manner: Boc-pyrrolidine (5.0 g, 29.2 mmol) is dissolved in ether (35 ml) and TMEDA (3.0 g, 20 mmol), cooled to -78 ° C and s-butyllithium (1.3 M, 17 ml, 22 mmol) is added. After stirring for 1 hour, allyl bromide (5.1 ml, 57 mmol) is added. After warming to room temperature, the reaction is suspended with water and the organic layer is separated. The organic layer is dried (MgSO4) and the solvent removed in vacuo to give the olefin (2.9 g, 47%, X NMR: (CDC13) d 5.65-5.85 (m, 1H), 5.00-5.20 (m, 2H ), 3.70-3.90 (m, 1H), 3.20-3.45 (m, 2H), 2.35-2.60 (M, 1H), 2.00-2.20 (m, 1H), 1.60-2.00 (m, 4H), 1.45 (s) , 9H)). To the olefin (1.0 g, 4.7 mmol) in THF (20 ml) at 0 ° C borane / THF is added. After warming to room temperature and stirring for 1 hour, H202 (30%, 14 ml) and 3 N NaOH (3.2 ml) are added. The reaction is partitioned with ethyl acetate and separated. The organic layer is dried and concentrated in vacuo.

The residue is added to NaI04 (1.2 g, 5.4 mmol) and Ru04 (10 mg, 0.08 mmol) in water (100 ml) and acetone (10 ml). After stirring for 1 hour, the reaction is concentrated and extracted with CH2C12. The organic layer is extracted with 1N NaOH, the aqueous layer is washed with CH2C12, made acidic with 1 N HCl and extracted with CH2C12. The organic layer is dried (MgSO.) and concentrated to provide 0.14 g (26%) of l-Boc-pyrrolidin-2-propionic acid; XH NMR: (CDC13) d 1.40 (m, 9H), 1.60-2.00 (m, 6H), 2.20 (m, 2H), 2.40 (m, 2H), 3.30 (m, 2H), 3.90 (m, 1H) . 4-Boc-thiomorpholine-3-carboxylic acid can also be substituted by the compound of formula (XXIV) in Reaction Scheme 7 and can be prepared as follows: To THF is added cysteine ethyl ether hydrochloride ( 1.15 g, 6.16 mmol), triethylamine (4.17 ml, 30 mmol) and dibromoethane (2.51 ml, 6.2 mmol). After stirring for 1 hour and refluxing for 16 hours, the solids are removed by filtration. The solvent is removed in vacuo and the residue chromatographed on silica to provide the thiomorpholinocarboxylic acid ethyl ester (0.94 g, 87%). The ester (15.3 g, 95 mmol) is dissolved in dioxane / water (1/1) and di-t-butyl dicarbonate (24 g, 110 mmol) and LiOH are added. After stirring for 3 hours, the solvent is removed in vacuo and the pH adjusted to 3 with KHS03 and extracted with ethyl acetate. The organic layer is separated, washed with brine, dried (MgSO4) and the solvent removed in vacuo to give 17.4 g (78%) of 4-Boc-thiomorpholine-3-carboxylic acid: H NMR: (CDC13) d 1.45 (m, 9H), 2.45 (m, 1H), 2.71 (m, 1H), 2.93 (m, 1H), 3.10 (m, 1H), 3.29 (m, 1H), 4.11 (m, 1H), 4.19 (m, 1H), 5.20 (m, 1H). 4-Boc-thiomorpholine-3-acetic acid can also be substituted for the compound of formula (XXIV) in Reaction Scheme 7 and can be prepared as follows: A THF (50 ml) is added methyl bromocrotonate (1.0 ml, 8.6 mmol), Hünig's base (1.5 ml, 8.6 mmol) and N-Boc-2-aminoethanethiol (1.5 g, 8.6 mmol). After stirring for 3 hours, the reaction is poured into saturated NH4C1 and extracted with ethyl acetate. The organic layer is washed with brine, dried (MgSO 4) and the solvent removed in vacuo. Chromatography (hexane / ethyl acetate, 6/1) gives the methyl ester of N-Boc-2-aminoethanethiocrotonic acid. The ester is dissolved in CH2C12 (80 ml) and TFA (20 ml) is added. After shaking during 1 hour, the solvent is removed in va cuo. The residue is added to a solution of toluene and TEA (2.5 ml). After stirring for 16 hours, the solvent is removed and the residue is subjected to chromatography to provide the thiomorpholine. Dissolve the ester (18.0 g, 95 mmol) in dioxane / water (1/1) and add di-t-butyl dicarbonate (19.6 g, 90 mmol) and LiOH.

After stirring for 12 hours, the solvent is removed in vacuo and the pH adjusted to 3 with KHS03 and extracted with ethyl acetate. The organic layer is separated, washed with brine, dried (MgSO4) and the solvent removed in vacuo to give 20.3 g (86%) of 4-Boc-thiomorpholine-3-acetic acid; X NMR: (CDC13) d 1.45 (m, 9H), 2.45 (m, 1H), 2.51 (m, 1H), 2.68 (m, 1H), 2.82 (m, 1H), 3.05 (m, 4H), 4.24 (s, 1H), 4.93 (s, 1H). 4-Boc-thiomorpholino-2-acetic acid can also be substituted by the compound of formula (XXIV) in Reaction Scheme 7 and can be prepared as follows: a THF (100 ml) is added diethyl fumarate ( 3.27 ml, 820 mmol), DBU (7.22 ml, 50 mmol) and aminoethanethiol hydrochloride (2.26 g, 20 mmol). After refluxing for 16 hours, the reaction is poured into saturated NaHCO 3 and extracted with ethyl acetate. The organic layer is washed with brine, dried (MgSO 4) and the solvent removed in vacuo. Chromatography (ethyl acetate) provides thiomorpholinone (2.61 g, 70%). The ester is dissolved in THF (50 ml) and borane / DMS (3 ml, 30 mmol) is added. After stirring for 16 hours, ethanol is added to suspend the reaction. HCl gas is bubbled into the reaction and the mixture is refluxed for 2 hours. The solvent is removed in vacuo and the residue is suspended in 0.5 M NaOH and CH2C12. The organic layer is separated, dried (Na 2 SO 4) and the solvent removed in vacuo. Chromatography on silica (MeOH / ethyl acetate) provides the starting material (0.71 g, 29%) and thiomorpholine (1.26 g, 56%). The ester (3.0 g, 11.4 mmol) is dissolved in dioxane / water (1/1) and di-t-butyl dicarbonate (2.29 g, 10.5 mmol) and LiOH are added. After stirring for 12 hours, the solvent is removed in vacuo and the pH adjusted to 3 with KHS04 and partitioned with ethyl acetate. The organic layer is separated, washed with brine, dried (MgSO 4) and the solvent removed in vacuo to provide 2.20 g (81%) of 4-Boc-thiomorpholine-2-acetic acid; XH NMR: (CDC13) d 1.44 (m, 9H), 2.59 (m, 4H), 3.17 (m, 1H), 3.2-4.0 (, 4H). Reaction Scheme 7 shows a synthesis in which a preformed protected compound of formula (XXI) is coupled to the resin and deprotected to allow reaction with the protected compound of formula (XXIV). It will be apparent to a person familiar with the art that the sequence of this series of reactions can be altered to provide the same deprotected piperonylamino-methyl-benzoyl resin. Follow an example of such a sequence. This example also illustrates the manner in which one can reverse the substitution pattern of the piperazine acetic acid ring. 4-Bromoethyl-3-nitrobenzoic acid (819 mg, 3.15 mmol) and HOBt (426 mg, 3.15 mmol) in 15 ml of DMF are treated., DIC (795 mg, 6.30 mmol) is added and the contents are stirred for 30 minutes at room temperature. The mixture is then added to the resin and stirred overnight. The resin is filtered, washed and dried as in the above. The resin shows a negative stain with ninhydrin. The resin is taken up in 15 ml of THF containing piperonylamine (1.51 g, 10 mmol) and stirred over a weekend. The resin is filtered, washed and dried (1.507 g). N1-Fmoc-N-Boc-piperazine-2-acetic acid (9.78 mg, 2.1 mmol), HATU (798 mg, 2.1 mmol) and DIEA (542 mg, 4.2 mmol) in 15 ml of DMF are mixed.; and then it is added to the resin. After stirring for 24 hours, the resin is filtered, washed and dried in a conventional manner; the resin weighs 1,693 g. The resin is taken up in 15 ml of 30% v / v piperidine in DMF, and stirred for 2 hours to remove the Fmoc protecting group. After filtration, the resin is subjected to the usual washing and the drying cycle; the resin weighs 1,588 g. The resin, acetic anhydride (591 mg, 5.8 mmol) and DIEA (748 mg, 5.8 mmol) are taken up in 15 ml of methylene chloride and stirred overnight to acetylate in N1. After filtration, the resin is washed with methylene chloride and dried in a vacuum desiccator for 5 hours. The resin is stirred with 15 ml of 1: 1 TFA: methylene chloride for 1 hour to remove the protective group tBoc in N. After filtration, the resin is washed with methylene chloride (5 x 15 ml), followed by 20% triethylamine in methylene chloride (5 x 15 ml) and then again with methylene chloride (5 x 15 ml). After drying, the resin weighs 1294 g. 669 mg of the resin from the previous step, DIEA (116 mg, 0.9 mmol) and 4-chloro-2- (1-imidazole) -6-isopropylpyrimidine (200 mg, 0.9 mmol) are taken up in 6 ml of DMF and heat at 80 ° C for 24 hours. After filtration the resin is washed (DMF, methanol and methylene chloride) and dried. A portion (377 mg) of the resin from the previous step is suspended in methanol and photolyzed at 50 ° C for 6 hours. The solution is filtered, the solvent is removed and the residue is purified by chromatography (silica, methylene chloride: methanol, 95.5), yield 14 mg. The X NMR and MS were consistent with the proposed structure. The following compounds, which are shown in Table 1 to Table 7 are representative of the compounds of the inventions and are synthesized by the preceding methods. All show inhibitory activity of iNOS at concentrations lower than 25 μM.

TABLE Ex. # R- R5 Rc R9 -CH.R3 -CH.R9 Cl Ac CH ^ -CH.R3 Boc -CH, R9 Boc -CH.R9 Cl Boc CH.

-CXR9 Cl -CH, R9 Cl -CH.R9 Cl "N" -CH-R9 -CH, R9 Cl - (CH. Cl H R9 -N ' -CH.RS Cl (X -CH, R9 H -CH.R9 Cl Boc -N ' 80 -. 80 - (CHUR9 Cl Boc - (CHUR9 CH. Boc 82 -. 82 - (CH,) U Cl Ac - 17: : CH -), R3 Cl C (0) CH- CH (CH,) 84 -. 84 - (CHUR5 Cl 85 XHUR9 CH, 86 -. 86 - (CHUR9 Cl Ac 87 -. 87 - (CH,) 2R9 Cl -C (0) CH, 88 -. 88 - (CH, XR3 CH, Ac - 17: .76 - 98 -. 98 -CH, R9 99 -. 99 -CH-R9 Cl C (0) OCH, -CH.R9 0 C (0) OCH3"Cl .77 - _7¡ - .79 -CH, R9 Cl -CH, R9 CH, -CH-R9 IPr - (CH,) .- Cl R9 1 - . 1 - TABLE 2 .84 or - .87 - 8S TABLE 3 Compound of the invention amino acid derivatives (AA, Q-R3 .92 .93 - - L94 - 193 - TABLE 4 Compound of the invention amino acid derivatives (AA) Q- J TABLE 5 Compound of the invention derived from amino acids 0-R TABLE 6 Physical data for the compounds of the invention TABLE 7 Linker group (L) Linker group (-L) Separating reagent Light Light Light .B ["R" is H or alkylene is O or NH; X is an electron withdrawing group such as Br, Cl or I; and it is the point of attachment of -C (O) -.] The following compounds were made according to the methods described herein: l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] piperazin-2- acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-methylphenyl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3-hydroxy-N - [(1,3-benzodioxol-5-yl) methyl] propanamide; 2- [[2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) methyl] pentanediamine: 2- [[2- (lH -imidazol-1-yl) pyrimidin-4-yl] amino] -5- [[amino (nitroimino) methyl] amino] -N - [(1,3-benzodioxol-5-yl) methyl] pentanamide; 2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3- (thiophen-2-yl) -N- [3- (morpholin-4-yl) propyl] propanamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] piperazin-2-acetamide; N - [(4-chlorophenyl) methyl] -1- [2,6-bis (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetamide; N- [(1, 3-benzodioxol-5-yl) methyl] -4- [2- (1H-imidazol-1-yl) -6-methoxypyrimidin-4-yl] -1- (methoxycarbonyl) piperazine-2- acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -4- (methoxycarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] piperidine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperidine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [phenylmethyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [3-phenylpropyl] piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2-phenylethyl] piperazin-2-acetamide; l- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(thiophene-2-yl) methyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (methyl) piperazin-2-acetamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3- (methylthio) -N - [(1,3-benzodioxol-5-yl) methyl] butanamide; 2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4- (methylthio) -N- [(4-methoxyphenyl) methyl] butanamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4- (methylthio) -N- [2- (3, 4-dimethoxyphenyl) ethyl] butanamide; 2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4- (methylthio) -N- (methyl) butanamide; 2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -3- [(1,1-dimethylethyl) thio] -N- [3- (methylthio) propyl] ] propanamide; 2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -3- [(1,1-dimethylethyl) thio] -N- [3- (phenyl) propyl] ] propanamide; a - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, 4-dimethoxyphenyl) ethyl] -2-thiophenpropanamide; a - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- (butyl) -2-thiophenpropanamide; a - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) methyl] -2-thiophenpropanamide; 2- [[6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] amino] -3 - [(1,1-di? Ethylethyl) thio] - N - [2 - (3 ,.-dimethoxyphenyl) ethyl] propanamide; 2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, 4-dimethoxyphenyl) ethyl] acetamide; 2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, 4-dimethoxyphenyl) ethyl] propanamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, 4-dimethoxyphenyl) ethyl] pentanediamide; 2- [[6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] amino] -N- [(4-methoxy phenyl) methyl] pentanediamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] pentanediamide; N- [(1,3-benzodioxol-5-yl) methyl] -2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -5- [[amino (nitroimino) methyl] -amino] pentanamide; 2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -N - [(4-methoxyphenyl) methyl] - 5 - [[imino (amino) methyl] amino] ] pentanamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3,4-dimethoxy phenyl) ethyl] pyr rol idin-2-carboxamide; 2- [[6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] amino] -N- [(4-methoxyphenyl) -etheyl] -5- [[irnino (nitroamino) methyl] - amino] pentanamide; N- [(1, 3-benzodioxol-5-yl) methyl) -2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -5- [[amino (imino) methyl] -amino] pentanamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -4-hydroxy-N- [4- (hydroxycarbonyl) phenyl] methyl] pyrrole idin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -3-hydroxypropanamide; 6-amino [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, 4-dimethoxy phenyl) ethyl] hexanamide; a- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [3- (methylsulfonyl) propyl] benzene-propanamide; N- [(1,3-benzodioxol-5-yl) methyl] -2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] (methyl) amino] acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -6 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] hexanamide; 5-amino-N- [(1, 3-benzodioxol-5-yl) methyl] -2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] pentanamide; 5-amino-N-butyl-2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] pentanamide; 4- [3-hydroxy-3-oxopropyl) amino] -3- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4-oxobutanoic acid; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] (methyl) amino] -N- [(pyridin-4-yl) methyl] acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N-methylpiperidine-2-carboxamide; N- [2- (3, 4-dimethoxyphenyl) ethyl] -α - [[6- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -2-thiophenpropanamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4-methylpentanamide; N- [(1, 3-benzodioxol-5-yl) methyl] -2- [[6-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] pentanediamide; N- [2 (3,4-dimethoxy phenyl) ethyl] -2- [[6- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -4-methylpentanamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3-hydroxypropanamide; N- [(1,3-benzodioxol-5-yl) methyl] -α- [[6- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] benzenepropanamide; 5 - [[amino (imino) methyl] amino] -6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (phenylmethyl) pentanamide; N- [(1,3-benzodioxol-5-yl) methyl] -1,4-bis [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperazin-2-acetamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4- [[phenyl] amino] carbonyl] -piperazin-2-acetamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4- [(methoxy) carbonyl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- (acetyl) -N- [(1,3-benzodioxol-5-yl) methyl] -4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperazin-2 -acetamide; 4- [2- (IH-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -1-methylpiperazin-2-acetamide; 4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -1-methylpiperazin-2-acetamide; N- [(3-chloro-4-methoxyphenyl) methyl] -4- [2- (IH-imidazyl-l-yl) -8-methylpyrimidin-4-yl] -l-methylpiperazin-2-acetamide; 4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -1-methylpiperazine-2-acetamide; 4- [ß-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4,5-trimethoxyphenyl) methyl] -1-methylpiperazin-2-acetamide; N- [2- (1, 4-benzodioxan-6-yl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -l-methylpiperazin-2-acetamide; l-butyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(furan-2-yl) methylpiperazine-2-carboxamide; N - [(4-Benzodioxan-6-yl) methyl] -l-butyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperazin-2-acetamide; N- [2- (1, 4-benzodioxan-6-yl) ethyl] -l-butyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazin-2 -acetamide; N- [(2,3-dimethoxyphenyl) methyl] -l-butyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperazine-2-acetamide; 4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -1- [(4-methoxyphenyl) methyl] piperazin-2 acetamide; 4- [6-methyl-2- (lH-imidazyl-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -1- [(4-methoxyphenyl) methyl] piperazin-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -1- [(4-methoxyphenyl) ethyl] piperazin-2-acetamide; 4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -l- [(4-methoxyphenyl) methyl] piperazine -2-carboxamide; 4- [6-met il-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -1- [(4-methoxyphenyl) methyl] piperazine- 2-acetamide; 4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -l- [(4-methoxyphenyl) methyl] piperazin-2 -acetamide; 4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methyl) phenyl) ethyl] -1 - [(4-methoxyphenyl) methyl] pipera zin - 2 -acet amide; 4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -1 - [(4-methoxyphenyl) methyl] piperazine -2-acetamide; 4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin-1-yl) -N- [(indan-5-yl) methyl] -l- [(4-methoxyphenyl) methyl] piperazine -2-acetamide; N- [(1, 3-benzodioxol-5-yl) methyl] -l- [(2,3-dichlorophenyl) methyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piper to zin-2 -acet amide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(3,4-dichlorodenyl) methyl] -4- [2- (1H-imidazol-1-yl) -6-met-ilpyrimidin- 4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(3,4-di chlorophenyl) methyl] -4- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] ] pipera zin-2 -carboxamide; 4- [6-met? L-2- (lH-? M? Dazol-1-? L) p? Pm? Dm-4-? L] -N- [2- (1,3-benzod? Oxol- 5 -?) Ethyl] -1 - [(3,4-d? Chlorophen? L) met? L] pipera zm-2-ace tamide; N- [(1,3-benzod? Oxol-5? L) met? L] -1- [(1,3-benzod? Oxol-5-yl) methyl] -4- [2- (lH-? m? dazol-1-? l) p? r? m? dm-4-lyl] p? perazm-2-acetamide; N- [(1, 3-benzod? Oxol-5? L) met? L] -1- [(1,3-benzod? Oxol-5-11) me 111] -4- [2- (lH- m? dazol-1-? l) -6-met? lp? nm? d? n-4-yl] p? perazm-2-carboxam? da; N- [(1,3-benzod? Oxol-5? L) met? L] -1- [(1,3-benzod? Oxol-5-11) me 111] -4- [6-chloro-2] - (1H-α-dazol-1-? l) p? r? m? d? n-4-íl] p? peraz? n-2-carboxam? da; N- [(1,3-benzod? Oxol-5? L) met? L] -1- [(1,3-benzod? Oxol-5-yl) methyl] -4- [6- (lH-? m? dazol-l-? l) p? pm? d? n-4-? l] p? perazm-2-carboxamide; N- [2- (1, 3-benzod? Oxol-5? L) ethyl] -1- [(1,3-benzod? Oxol-5? L) met? L] -4- [2- ( lH-? m? dazol-1-? l) -6-met? lp? r? m? d? n-4-íl] pipe razm- 2 -acet amide; N- [2- (1, 3-benzod? Oxol-6? L) ethyl] -1- [(1,3-benzod? Oxol-5? L) met? L] -4- [2- ( 1H-α-dazol-1-yl) -6-met? lp? r? m? dm-4-yl] piper az? n-2-acet amide; N- [(4-methox? Phen?) Met? L] -1- [(1,3-benzod? Oxol-5-11) me 111] -4- [2- (lH-? M? Dazol- 1-? L) -6-met? Lp? R? M? Dm-4-yl] p? Perazm-2-carboxam? Da; N- [(4-methoxyphenyl) methyl] -l- [(1, 3-benzodioxol-5-y1) me ti 1] -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin- 4-yl] piperazin-2-acetamide; N- [(4-methoxyphenyl) methyl] -1- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-l-yl) -6- (iso-propyl) pir imi in- 4-yl] pipera zin-2-acetamide; N- [2- (4-methoxyphenyl) ethyl] -1- [(1,3-benzodioxol-5-y1) me ti 1] -4- [2- (lH-imidazol-1-yl) -6- methylpyrimidin-4-yl] piperazin-2-acetamide; N - [[2- (phenyl) cyclopropyl] amino] -1- [(1,3-benzodioxol-5-yl) methyl] -4- [β-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazin-2-carboxamide; N- [(4-ethoxyphenyl) methyl] -1- [(1,3-benzodioxan-6-y1) me ti 1] -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin- 4-yl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(1,3-benzodioxan-6-yl) methyl] -4- [2- (lH-imide zol-1-yl) - 6- (iso-propyl) pyrimin din-4-yl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(1,3-benzodioxan-6-yl) methyl] -4- [2- (lH-imi azol-l-yl) pyrimidine -4-yl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1 - [(1,3-benzodioxan-6-yl) methyl] -4- [6- (lH-imidazol-1-yl) pyrimidine- 4-yl] piperazine-2-carboxamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -l - [(1,3-benzodioxan-6-yl) methyl] -4- [2- (lH-imide zol-1-yl ) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -1 - [(1,3-benzodioxan-6-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piper a zin-2 -carboxamide; N- [(4-methoxyphenyl) methyl] -l- [(1, 3-benzodioxan-6-yl) methyl] -4- (1 H -imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazine -2-acetamide; N- [(3,4-dimethoxy phenyl) methyl] -1- [(1,3-benzodioxan-6-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6- ( iso-propyl) pyrimidin-4-yl] piperazin-2-acetamide; N- [(3,4-dimethyl phenyl) methyl] -1- [(1,3-benzodioxan-6-yl) me ti 1] -4- [2- (lH-imidazol-1-yl) - 6-chloropyrimidin-4-yl] piperazin-2-acetamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -1- [(pyrimin-3-y1) me ti 1] -A- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [(1,4-Benzodioxan-6-yl) methyl] -1- [(pyridin-3-yl) methyl] -4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperazine-2-carboxamide; N- [2- (1, -benzodixoan-6-yl) ethyl] -1- [(pyridin-3-y1) me ti 1] -4- [2- (lH-imidazol-l-yl) -6 -methylpyrimidin-4-yl] piperazin-2-acet amide; N- [(4-methoxyphenyl) methyl] -l- [(pyridin-3-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazin-2 -carboxamide; N- [(3,4-dimethoxy phenyl) methyl] -1- [(pyridin-3-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6- (iso-propyl) pyrimidin-4-yl] piperazin-2-acetamide; N- [2- (3,4-dimethoxyphenyl) ethyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] - A - [2- (lH-imidazol-1-yl) -6- (isopropyl) pyrimidin-4-yl] piper to zin-2-acet amide; N- [3- (3,4-dimethoxyphenyl) propyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-imidazol-1-yl) -6- (isopropyl) pyrimidin-4-yl] piperazin-2-acetamide; N- [(4-ethoxyphenyl) methyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-imidazol-l-yl) -6-met-ilpyrimidin-4-yl] piperazin-2-acetamide; N- [2- (4-methylphenoxy) ethyl] -1- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-imide zol-1-yl) -6-chloropyrimidin-4- il] piperazin-2-acetamide; N- [(4-methylphenyl) methyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazine -2-acetamide; N- [(4-chlorophenyl) methyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (1 H -imidazol-1-yl) -6-met-ilpyrimidin-4-yl ] piperazin-2-acet amide; N - [(4-chlorophen? L) met? L] -1 - [(3-fluoro-4-methox? Phen? L) met? L] -4- [2- (lH-? M? Dazol-1 -? l) -6-chlorop? r? m? dm-4-yl] p? perazm-2-acetam? da; N- [(1, 3-benzod? Oxol-5? L) met? L] -l- [(3-fluoro-4-methox? Phen? L) met? L] -4- [2- (lH -? m? dazol-1-? l) -6-chlorop? pm? d? n-4-yl] p? perazm-2-acetam? da; N- [2- (1, 3-benzod? Oxol-5? L) et? L] -l- [(3-fluoro-4-methox? Phen?) Met? L] -4- [2- (lH-? m? dazol-1-? l) -6-met? lp? r? m? dm-4-yl] piperaz? n-2-acet amide; N- (2- (1, 3-benzod? Oxol-5? L) et? L] -l- [(3-fluoro-4-methox? Phen?) Met? L] -4- [2- (lH-? m? dazol-1-? l) p? pm? dm-4-yl] piper az? n-2-acet amide; N- [2- (l, 4-benzod? oxan-6? l) et? l] -l - [(3-fluoro-4-methox? phen? l) met? l] -4- [2- (lH-? m? dazol-1-? l) p? r? m? d? n-4-yl] peraz? n-2-acetam? da; N- [2- (4-methox? phen? l) ethyl] -1- [(3-fluoro-4-methoxy) fen? l) met? l] -4- [2- (lH-? m? dazol-1-? l) -6- (iso-propyl) p? pm? d? n-4-? l] pipera zin-2 -acet amide; N- [(3,4-d? methox? phen?) ethyl] -l-acet? l-4- [2- (1H-? m? dazol-1-? l) -6- (iso-propyl) p? R? M? Dm-4-? L] pipera z? N-2-acetamide; N- [(4-ethoxy? Phen? L) met? L] -l-acet ? l-4- [2- (lH-? m? dazol-1-yl) -6- (iso-propyl) p? r? m? dm-4-? l] pipera z? n-2-carboxam? da; N- [2- (4-meth? lfenox?) ethyl] -l-acet? l-4- [2- (lH-imidazol-l-yl) -6-chlorop? pm? dm-4-? l] peraz? n-2-acetam? da; N- [2- (3-Chloro-4-methoxyphenyl) ethyl] -1-acetyl-4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazin-2 - carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -l-acetyl-4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piper a zin-2 - acet amide; N- [(4-methoxyphenyl) methyl] -l-acetyl-4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazine-2-carboxamide; N - [(4-methoxyphenyl) methyl] -l-acetyl-4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazin-2-acetamide; N- [2- (3,4-dimethoxy phenyl) ethyl] -1- (3-methyl-1-oxobutyl) -4- [2- (1 H-imidazol-1-yl) -6- (iso-propyl) ) pyrimidin-4-yl] piperazin-2-acetamide; N- [2- (3,4-dimethoxy phenyl) ethyl] -1- (3-met il-1-oxobutyl) -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidine- 4-yl] piperazine-2-carboxamide; N- [2- (3-Chloro-4-methoxyphenyl) ethyl] -l- [3-met il-1-oxobutyl) -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4 -yl] piper to zin-2 -carboxamide; N- [2- (3-Chloro-4-methoxyphenyl) ethyl] -1- (3-methyl-l-oxobutyl) -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4- il] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- (3-methyl-1-oxobutyl) -4- [2- (1H-imidazol-1-yl) pyrimin-4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol-6-yl) methyl] -1- (3-methyl-l-oxobutyl) -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4- il] piper a zin-2 -carboxamide; N- [2- (1, 3-benzodioxan-6-yl) ethyl] -l- (3-methyl-l-oxobutyl-4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4 -yl] piperazine-2-carboxamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- (3-methyl-1-oxobutyl) -4- [2- (1H-imidazole-1 il) -6-chloropyrimidin-4-yl] piperazin-2-carboxamide; N- [2 (1,4-benzodixol-5-yl) ethyl] -l- (3-methyl-l-oxobutyl) -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazine-2-carboxamide; N- [2 (1,4-benzodixol-5-yl) ethyl] -1- (3-methyl-1-oxobutyl) -4- [2- (1H-imidazol-1-yl) -6- (trifluoromethyl) pyrimidin-4-yl] piperazin-2-acetamide; N- [(2,6-dimethoxyphenyl) methyl] -1- (3-methyl-1-oxobutyl) -4- [2- (1H-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazine- 2-acetamide; N- [2- (3,4-dimethoxyphenyl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imide zol-1-yl) -6- (iso-propyl) pyrimidin-4-yl ] piperazin-2-acetamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] pipera zin -2-carboxamide; N- [2- (1, 3-benz odi-oxol-5-yl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imide zol-1-yl) -6-chloropyrimidin-4- il] piperazin-2-acetamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6- (trifluoromethyl) pyrimidin-4-yl ] piperazin-2-acetamide; N- [(3,4-Dimethylphenyl) methyl] -1- (methoxyacetyl) -4- [6- (1H-imidazol-1-yl) -6- (trifluoromethyl) pyrimidin-4-yl] piperazin-2- carboxamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6- (iso-propyl) pyrimidin-4-yl) ] piperazin-2-acetamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6- (iso-propyl) pyrimidin-4-yl ] piperazine-2-carboxamide; N- [2- (1, 4-benzodioxan-6-yl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6- (trifluoromethyl) pyrimidin-4-yl ] piperazin-2-acetamide; N- [(4-methoxy phenyl) methyl] -1- (methoxyacetyl) -4- [2- (1H-imidazol-1-yl) -6-met-ilpyrimidin-4-yl] piperazin-2 -acet amide; N- [2- (3,4-dimethoxy phenyl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-1-yl) -6- chloropyrimidin-4-yl] piperazine-2-carboxamide; N- [(4-methylphenyl) methyl] -l- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazine-2 -acetamide; N- [2- (4-chlorophenyl) ethyl] -l - [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] piperazine -2-acetamide; N- [(3-chloro-4-methoxyphenyl) methyl] -1- [(tetrahydrofuran-2-yl] carbonyl] -4- [2- (lH-imidazol-l-yl) -6-chloropyrimidin-4-yl ] piperazine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (1H-imidazol-1-yl) ) pyrimidin-4-yl] piperazine-2-carboxamide; N - [(1,3-benzodioxol-5-yl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [6- (1H -imidazol-1-yl) pyrimidin-4-yl] piperazine-2-carboxamide; N- [2 (1,3-benzodioxol-5-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] - 4- [2- (1H-imidazol-1-yl) -6-pyrimidin-4-yl] piperazine-2-acetamide; N- [2- (1,3-benzodioxol-5-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazine-2-acetamide; N- [2 (1,3-benzodioxol-5- il) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-l-yl) -6- (iso-propyl) pyrimidin-4-yl] piperazin-2- acetamide; N- [2 (1,3-benzodioxol-5-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidine -4-yl] piperazine-2-carboxamide; N- [(1,4-benzodioxol-6-yl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (1H-imidazol-1-yl) -6- (iso -propyl) pyrimidin-4-yl] piperazin-2-acetamide; N- [(1,4-benz odi oxan-6-yl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-1-yl) -6- (Chloropyrimidin-4-yl] piperazin-2-acetamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- ( lH-imide zol-1-yl) -6-chloropyrimidin-4-ylpiperazin-2-carboxamide; N- [2- (1,4-benzodioxan-6-yl) ethyl] -1- [(tetrahydrofuran -2-yl) carbonyl] -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl}. Piperazine-2-carboxamide; N- [(4-methoxyphenyl) methyl] - l- [(Tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-l-yl) -6-chloropyrimidin-4-yl] piperazin-2 -acetamide; N- [2- (4 -methoxy phenyl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imide zol-1-yl) -6-chloropyrimidin-4-yl] pipe ra zin- 2 - carboxamide; N- [2- (3-methoxy phenyl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-l-yl) -6-chloropyrimidin-4- il] piperazin-2 -carboxamide; N- [(1,4-benzodioxan-2-yl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (1H-imidazol-1-yl) -6- (iso- propyl) pyrimidin-4-yl] piperazine-2-carboxamide; N- [(3,4-dimethoxy phenyl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (1H-imidazol-1-yl) -6- (iso-propyl) pyrimidine -4-yl] piperazin-2-acetamide; N- [(3,5-dimethoxy phenyl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazin-2-acetamide; N- [(4-Ethoxyphenyl) methyl] -l- [(2-hydroxy-2-oxoethoxy) acetyl] -4- [2- (IH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazine -2-carboxamide; N- [(3-chloro-4-methoxyphenyl) methyl] -l- [(2-hydroxy-2-oxoethoxy) acetyl] -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4 -yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(2-hydroxy-2-oxoethoxy) acetyl] -4- [2- (IH-imidazol-1-yl) -6-methylpyrimidine -4-yl] piperazine-2-carboxamide; N- [2- (3,4-dimethoxy phenyl) ethyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazine-2-acetamide; N- [3- (3, 4-dimethoxyphenyl) propyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazin-2-acetamide; N - [(4-methylphenyl) methyl] -l- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- (phenoxyacetyl) -4- [2- (1 H -imidazol-1-yl) pyrimidin-4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- (phenoxyacetyl) -4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazin-2-acetamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazine-2-acetamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piperazine- 2-carboxamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- (f-enoxyacetyl) -4- [2- (lH-imide zol-1-yl) -6-chloropyrimidin-4-yl] pipera zin - 2 -acetamide; N- [2- (1,4-benzodioxan-5-yl) ethyl] -1- (f-enoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] piper to zin-2 -acet amide; N - [(4-methoxy phenyl) methyl] -1- (f-enoxyacetyl) -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazin-2-acetamide; N - [(4-methoxy phenyl) ethyl] -l- (phenoxyacetyl) -4- [2- (lH-imide zol-1-yl) -6-chloropyrimidin-4-yl] piperazine-2-carboxamide; N- [2- (4-methoxyphenyl) ethyl] -1- (f-enoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [2- (4-methoxy phenyl) ethyl] -1- (f-enoxyacetyl) -4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] pipe ra zin-2 -acet amide; N - [2 - (3,4-d imet ox ifenyl) ethyl] -1 - [(4-e-phenyl phenyl) carbonyl] -4- [2- (lH-imidazol-1-yl) -5-chloropyrimidine- 4-yl] piper a zin-2-acet amide; N- [(1, 3-benzod? Oxol-5? L) met? L] -4- (6-fluorop? R? Dm-2-yl) -1- [2- (lH-? M? -1-? L) p? R? M? Dm-4-? L] pipe razm- 2 -acet amide; 1- (acetyl) -4- [2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? L] -N- [(4-methylsulfon? Lfen? l) I use] piperazin-2-acet amide; l- [2- (lH-? m? dazol-l-? l) p? r? m? dm-4-? l} -N- [(4-methersulfon? Lfen? L) met? L] pipe ridin-2-acet amide; N- [(1,3-benzod? Oxol -5 -? L) met? l] - 4 - [[2 - (etox? carbon? l) met? l] -l- [2- (lH-? m? dazol-l-? l) p? nm? d? n-4-íl ] p? peraz? n-2-acetam? da; 4- [ammo (idem) methyl] -N- [(1, 3-benzod? Oxol-5? L) methyl] -1- [2- (lH-? M? Dazol-1-? L) p? r? m? dm-4-? l] pipe reason-2 -acet amide; l-methersulfonyl-4- [6-met? l-2- (lH-? m? dazol-1-yl) p? r? m? dm-4-? l] -N- [2- (1,4-benzod? Oxan-6? L) ethyl] p? Peraz? N-2-acetamide; l-methylsulfonyl-4- [2- (lH-? m? dazol-1-? l) p? pm? d? n-4-? l} - N- { 2- (1, 4-benzod? Oxan-6-? L) ethyl] piperazm-2-acet amide; l-methylsulfonyl-4- [6-met? l-2- (lH-? m? dazol-1-? l) p? pm? d? n-4-? l] -N- [2 - (4-methox? Phen? L) et? L] peraz? N-2-acetamide; l-methersulfon? l-4- [6-? so-prop? l-2- (lH-? m? dazol-l-l) p? pm? dm-4-? l] -N- [( 3,4-dimethoxy-enyl] methyl] p? Peraz? N-2-acetamide; l- (n-oct? L) sulfon? L-4- [6-methyl 1-2- (lH-? M? Dazol- 1-?) P? R? M? Dm-4-? L] -N- [2- (3, 4-d? Methox? F enyl) et? L] p? Perazm-2-acetamide; 1- (n-octyl) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methyloxy) methyl) ] piperazin-2-acetamide; 1- (n-octyl) sulphonyl 4- [6- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] pipera zin - 2 -acet amide; 1- (n-octyl) sulfonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazin-2-acetamide; 1- (n-octyl) sulfonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (n-octyl) sulfonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-methoxyphenyl) methyl] piperazin-2- acetamide; 1- (n-octyl) sulfonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-fluorophenyl) sulfonyl] piperazine-2-acetamide; 1- (4-methylfenyl) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(pyridin-3-yl) methyl] piperazine- 2-carboxamide; 1- (4-methylfenyl) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperazin-2- carboxamide; 1- (4-methylphenyl) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] piperazin-2- carboxamide; 1- (4-methoxyphenyl) sulfonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethyl] piperazine- 2-acetamide; 1- (4-methoxyphenyl) sulfonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazine-2-carboxamide; l- (4-methoxyphenyl) sulfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-6-yl) ethyl] piperazine- 2-carboxamide; 1- (4-methoxyphenyl) sulfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazine- 2-acetamide; 1- (4-methoxyphenyl) sulfonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxy phenyl) methyl] piperazine-2 -acetamide; 1- (4-methoxyphenylsulfonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) sulfonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ) methyl] piperazine-2-carboxamide; 1- (4-methoxyphenyl) sulfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(2-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) sul foni 1-4- [6-met i 1-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazin-2-acet amide; 1- (4-methoxy phenyl) sul foni 1-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) sulphonyl 4- [6-methyl-2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) sulphonyl 4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxy phenyl) methyl) ] pipera zin-2 -carboxamide; 1- (4-methoxy phenyl) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] piperazine-2 -carboxamide; 1- (4-fluorophenyl) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazin-2-acetamide; 1- (Fluorophenyl) sulfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2 -acetamide; 1- (dimethylamino) sulfonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] pipera zin-2 -acet amide; 1- (dimethylamino) sulfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-chloro-4-methyl-phenyl) ethyl] pipera zin-2 -acetamide; 1- (dimethylamino) sulfonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl) ] piperazin-2-acetamide; 1- (dimethylamino) sulfonyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,3-benzodioxol-5-yl) methyl] piperazine-2-carboxamide; 1- (dimethylamino) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazin-2-acetamide; 1- (dimethylamino) sulfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- (dimethylamino) sulfonyl-4- [6-trifluo romet il-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl) ] piper a zin-2 -acet amide; 1- (dimethylamino) sulfonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piper to zin-2 -acet amide; 1- (dimethylamino) sulfonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] pipe ra zin-2-acetamide; 1- (dimethylamino) sulfonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazine-2 -acetamide; 1- (dimethylamino) sulfonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyri my din-4-yl] - N - [(3,4-dimethoxy-enyl) methyl] pipe razin-2 -acet amide; 1- (n-propyl) aminocarbonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimin din-4-yl] -N- [2- (3,4-dimethoxy-enyl) ethyl ] piperazin-2-acetamide; 1- (n-propyl) aminocarbonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methylphenoxy) ethyl] piperazin-2 -carboxamide; 1- (n-propyl) aminocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-chlorophenyl) ethyl] piperazin-2- carboxamide; 1- (n-propyl) ami noca rbonyl-4- [6-met il-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methyloxy) phenyl ) methyl] piperazin-2-acetamide; 1- (n-propyl) ami noca rbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-chloro-4-methyl) phenyl) ethyl] piperazine-2-carboxamide; 1- (n-propyl) aminocarbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazin-2-carboxamide; 1- (n-propyl) aminocarbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl) ] piperazine-2-carboxamide; 1- (n-propyl) ami noca rbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ) I use] pipera zin-2-acetamide; 1- (n-propyl) ami noca rbonyl- 4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole -5- il) ethyl] pipera zin-2 -carboxamide; 1- (n-propyl) aminocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin-2-acetamide; 1- (n-propyl) aminocarbonyl-4- [6- (IH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin - 2-carboxamide; 1- (n-propyl) aminocarbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piper to zin -2 -carboxamide; 1- (n-propyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl] piperazin-2- carboxamide; 1- (n-propyl) aminocarbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy-enyl) methyl] piperazine- 2-acetamide; 1- (cyclohexyl) aminocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3,4-dimethoxy phenyl) ethyl] pipe -2-acetamide; 1- (cyclohexyl) aminocarbonyl-4- [6-met il-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N - [(4-ethoxy phenyl) methyl] piperazine-2-carboxamide; 1- (cyclohexyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-chloro-4-methyl-phenyl) ethyl] piperazine-2 -acetamide; 1- (cyclohexyl) ami noca rboni 1-4 - [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-chloro-4-methoxyphenyl) ethyl] piperazin-2-acetamide; 1- (cyclohexyl) ami noca rbonyl-4- [6-chloro-2- (1 H-imidazo 1 -1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- (cyclohexyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazin-2- acetamide; 1- (cyclohexyl) aminocarbonyl-4- [6 (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin-2 carboxamide; 1- (cyclohexyl) aminocarbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] pipera zin-2 -carboxamide; 1- (cyclohexyl) aminocarbonyl-4- [6-met il-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] pipera zin-2-carboxamide; 1- (cyclohexyl) aminocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] pipera zin - 2-carboxamide; 1- (cyclohexyl) aminocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazine- 2-acetamide; 1- (cyclohexyl) aminocarbonyl-4- [6-trifluoromet-il-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (cyclohexyl) aminocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazine-2-carboxamide; 1- (cyclohexyl) aminocarbonyl-4- [6-met il-2- (1 H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] pipe ra zin-2-carboxamide; 1- (cyclohexyl) amino-ca rbonyl-4 - [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-2-yl) methyl] piper to zin-2-carboxamide; 1- (cyclohexyl) aminocarbon? L-4- [6-? So-prop? L-2- (1H-? M? D a z or l-1-? L) p? r? m? d? n - 4 -? l] - N - [(2,3-dimethoxy-enyl) -methyl] -2-carboxamide; 1- (cyclohexyl) am? Nocarbon? L-4- [6-chloro-2- (lH-imidazol-1-yl) p? Pm? D? N-4-? L] -N- [(2, 3 -d? methox? f enyl) met? l] p? perazm-2-carboxamide; 1- (phenylsulfonyl) am? Nocarbon? L-4- [6-chloro-2- (1H-? M? Da z or l-1-? L) p? r? m? d? n - 4 -? l] -N - [2 - (3,4-dimethoxyphenyl) ethyl] piper a z? n-2-acet amide; l- (p-sulfonyl) ammocarbon-l-4- [6-met? l-2- (lH-? m? dazol-1-? l) p? r? m? dm-4-? l] -N- [(4-etox? Phen? L) methyl] piper azm-2-acetam? Da; 1- (phenylsulfonyl) aminocarbon? L-4- [2- (lH-? M? Dazol-1-yl) p? R? M? Dm-4-? L] -N- [(4-ethoxy? fyl) methyl] piperazn-2-acetyl amide; 1- (phenylsulfonyl) am? Nocarbon? L-4- [6-chloro-2- (1H-? M? D a z or l-l-? L) p? r? m? d? n - 4 -? l] - N - [2 - (4-methylphonoxy) ethyl] piperazn-2-acetyl amide; 1- (phenylsulfonyl) am? Nocarbon? L-4- [6-chloro-2- (lH-imidazol-1-yl) p? R? M? Dm-4-? L] -N- [(4-met L-methyl) methyl] piperaz-2-acetamido; 1- (phenylsulfonyl) aminocarbon? L-4- [6-met 11-2- (1H-? M? Dazol-1-? L) p? R? M? D? N-4-? L] - N- [2- (3-chloro-4-methox? Phen? L) et? L] pipe razm- 2 -acet amide; 1- (phenylsulfonyl) aminocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] p iper to zin-2 -acet amide; 1- (phenylsulfonyl) aminocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazine- 2-carboxamide; 1- (phenylsulfonyl) aminocarbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] pipera zin -2 -carboxamide; 1- (phenylsulfonyl) aminocarbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] pipera zin - 2 -acetamide; 1- (phenylsulfonyl) aminocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (phenylsulfonyl) aminoca rbonyl-4 - [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin- 2-acetamide; 1- (phenylsulfonyl) aminocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- (phenylsulfonyl) aminocarbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(2,5-dimethoxy phenyl) methyl] pipera zin-2 - acetamide; 1- [2- (thien-2-yl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazine-2-carboxamide; l- [2- (Thien-2-yl) ethyl] -4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol- 5-yl) methyl] piperazine-2-carboxamide; 1- [2- (thien-2-yl) ethyl] -4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 4- benzodioxan-6-yl) methyl] piperazin-2-acetamide; l- [2- (Thien-2-yl) ethyl] -4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan- 6-yl) methyl] piperazine-2-carboxamide; l- [2- (Thien-2-yl) ethyl] -4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(2,3-dimethoxyphenyl) methyl] piperazin-2-acetamide; l- [2- (Thien-2-yl) ethyl] -4- [6-iso-propyl-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] piperazin-2-acetamide; 1- (4-methoxy phenyl) aminocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] piperazine-2-carboxamide; l- (4-methoxyphenyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (2,4-dimethoxyphenyl) ethyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) aminocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] ] piperazine-2-carboxamide; 1- (4-methoxy phenyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazine -2-acetamide; 1- (4-methoxyphenyl) ami noca rbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] pipe -2-carboxamide; 1- (4-methoxyphenyl) aminocarbonyl-4- [6-chloro-2- (1H-im? Dazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piper to zin -2 -carboxamide; l- (4-methoxyphenyl) aminocarbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (4-methoxyphenyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-methoxyphenyl) methyl] piperazine-2-acetamide; 1- (3,4-dichlorophenyl) aminocarbonyl-4- [6-met i 1-2- (1H-imi zol-1-yl) pi rimi di n-4-yl] -N - [2 - ( 3, A-dimethoxyphenyl) ethyl] piperazine-2-acetamide; 1- (3,4-dichlorophenyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin-2-acetamide; 1- (3,4-dichlorophenyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] pipera zin-2-acetamide; 1- (3, 4-dichlorophenyl) ami noca rbonyl -4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-en-1) methyl] piperazin-2-carboxamide; 1- (3,4-dichlorofenyl) aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) methyl] piperazine-2-carboxamide; 1- (methoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3,4-dimethoxy phenyl) ethyl] piperazine- 2-acetamide; 1- (methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin-4-yl] -N- [2- (3,4-dimethoxy phenyl) ethyl] piperazine- 2-carboxamide; 1- (methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro- 4 -met oxy f-ethyl) methyl] piperazin-2-acetamide; 1- (methoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-chloro-4-methoxy phenyl) ethyl] piperazin-2-acetamide; 1- (methoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazin-2-acetamide; 1- (methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazin-2-acetamide; 1- (methoxy) carbonyl-4- [2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [2- (1, 4-benzodioxan-6-yl) ethyl] piperazin 2-carboxamide; 1- (methoxy) carbonyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piper a zin-2 -acet amide; 1- (methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazine-2-carboxamide; 1- (methoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- (methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(cyclopropyl) methyl] piperazine-2-carboxamide; 1- (iso-propoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methylphenoxy) ethyl] piperazin-2- carboxamide; 1- (iso-propoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] piperazine-2-carboxamide; 1- (iso-propoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxole-5 -i 1) me useful] piperazine-2-carboxamide; 1- (iso-propoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] pipera zin- 2-acetamide; 1- (iso-propoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazine-2-carboxamide; 1- (Iso-propoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [[(3,4-dimethoxyphenyl) methyl] piperazine-2 -carboxamide; 1- (iso-propoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] piperazine- 2-carboxamide; 1- (iso-propoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- (cyclopropyl) piperazine-2-acetamide; 1- (n-butoxy) carboni1-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazin-2- acetamide; 1- (n-butoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3-benzodioxol-5-yl) ethyl] piperazine- 2-acetamide; 1- (n-butoxy) carbonyl-4 [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl) ] piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (n-butoxy) carbonyl -4- [6-methyl-2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazin-2 -acetamide; 1- (n-butoxy) carbonyl-4- [β-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazin-2- carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-iso-propyl-2- (lH-i midazol-1-yl) pyri my din-4-yl] - N - [3 - (4 - dimethoxyphenyl) propyl] piperazine-2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole -5-yl) ethyl] piperazin-2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6) -yl) methyl] piperazin-2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N - [(4-benzodioxan-6-yl) methyl] piperazine -2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-met i 1-2- (1 H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 4- benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin din-4-yl] -N- [2- (4-methoxy-enyl) ethyl ] piperazin-2-acetamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimin-din-4-yl] -N- [2- (3-methoxyphenyl) ethyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methylphenoxy) ethyl] piperazin-2- acetamide; l- ((phenyl) methoxy) carbonyl-4 - [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ) methyl] piperazin-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; l- ((phenyl) methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazine-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-met il-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazine -2-acetamide; 1- ((phenyl) methoxy) carbonyl-4- [6-met il-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] piperazine -2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-iso-propyl-2- (1H-y my da zol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxylated) ) methyl] pipera zin-2 -acet amide; 1- (4-methoxyphenyl) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin -2-acetamide; 1- (4-methoxy phenyl) carbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole-5 -yl) ethyl] pipera zin-2-acetamide; 1- (4-methyl-phenyl) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole-5 -yl) ethyl] piperazine-2-carboxamide; 1- (4-methoxyphenyl) carbonyl-4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin -2-acetamide; 1- (4-methoxy phenyl) carbonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimin din-4-yl] -N - [(4-benzodioxan-6-yl) methyl ] piperazine-2-carboxamide; 1- (4-methoxy phenyl) carbonyl-4- [6-met il-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine- 2-acetamide; 1- (4-methyl-phenyl) carbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) il) methyl] piperazine-2-carboxamide; l- (pyridin-3-yl) carbonyl-4- [6-met i 1-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethyl] piperazin-2-acetamide; l- (pyridin-3-yl) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin din-4-yl] -N- [(1,3-benzodioxol-5-yl) ) methyl] pipera zin-2-carboxamide; l- (pyridin-3-yl) carbonyl-4- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin-2-acetamide; 1- (phenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- (phenoxy) carbonyl -4- [6-iso-propyl-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazin-2 -carboxamide; 1- (4-methoxyphenoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benz odi-oxol-5-yl) methyl] piperazine- 2-carboxamide; 1- (4-methoxy phenoxy) carbonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) useful] piperazine-2-carboxamide; 1- (4-methox? Pheno?) Carbon? L-4- [2- (lH-? M? Dazol-1-yl) p? R? M? Dm-4-? L] -N- [2- (1, 3-benzod? Oxol-5? L) ethyl] p? Perazm-2-acetarruda; 1- (4-methox? F enoxi) carbon? L-4- [6-chloro-2- (lH-? M? Dazol-1-yl) p? R? M? Dm-4-? L] -N - [2- (1, 3-benzod? Oxol-5? L) ethyl] p? Peraz? N-2-carboxamide; 1- (4-methox? Phenox?) Carbon? L-4- [6- (lH-? M? Dazol-1-yl) p? R? M? D? N-4-? L] -N- [ (1,4-benzod? Oxan-6-? L) methyl] piperaz? N-2-carboxamide; l- (4-methox? pheno?) carbon? l-4- [2- (lH-? m? dazol-l-l) p? r? m? dm-4-? l] -N- [2- (1,4-benzod? Oxan-6-? L) ethyl] piperaz? N-2 -carboxamide; 1- (4-methox? Pheno?) Carbon? L-4- [6-chloro-2- (lH-? M? Dazol-1-yl) p? Nm? D? N-4-? L] -N - [2- (4-methox? Phen? L) ethyl] p? Peraz? N-2-acetamide; 1- (4-methox? Pheno?) Carbon? L-4- [6-chloro-2- (lH-? M? Dazol-1-? L) p? R? M? D? N-4-? ] -N - [(2,4-d? Methox? Phen? L) met? L] p? Perazm-2-carboxamide; 1- (4-methox? Pheno?) Carbon? L-4- [6-met? L-2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? ] -N- [(3,4-d? Methox? Phen? L) met? L] p? Perazm-2-carboxamide; 1- ((phenol) methox?) Carbon? L-4- [6-? So-prop? L-2- (1H-? M? D a z or l-1-? L) p? r? m? d? n - 4 -? l] - N - [2 - (4-methylphonoxy) ethyl] p? perazm-2-carboxamide; 1- ((phenyl) methoxy) carbonyl -4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methylphenoxy) ethyl] piperazin-2 -carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] pipera zin- 2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ) methyl] piperazin-2-acetamide; l- ((phenyl) methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) me useful] piperazine-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-met i 1-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5 -yl) ethyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-met i 1-2- (lH-imidazol-1-yl] pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- (1-methylpropoxy) carbonyl-4- [5-chloro-2- (lH-imidazol-1-yl] pyrimidin-4-yl] -N- [(1, 3 - benzodioxol -5-yl) methyl] piperazin-2-acetamide; 1- (1-methylpropoxy) carbonyl-4- [6- (lH-imidazol-1-yl] pyrimidin-4-yl] -N- [(1 , 3-benz odi oxol-5-yl) methyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl] pyrimidin-4-yl] -N-. {(1,4-benzodioxan-6-yl) methyl] pipe razin-2-acetamide; 1- (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl] pyrimidin-4-yl] -N- [(1, 4 -ben z odi oxan-6-yl) methyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6- (lH-imidazol-1-yl] pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [2- (lH-imidazol-1-yl] pyrimidin-4-yl] ] -N- [1- (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazol- 1-yl] pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-met il-2- (lH-imidazole -1-yl] pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazin-2-acetamide; 1- (phenoxy) -carbonyl-4- [6-iso-propyl-2 - (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2- (3,4-dimethoxy phenyl) ethyl] piperazin-2-acetamide; 1- (phenoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N-. { 2- (3, 4-dimethoxyphenyl) ethyl] piperazine-2-acetamide; 1- (phenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3,4-dimethoxyphenyl) ethyl] piperazin-2- acetamide; 1- (phenoxy) carbonyl-4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,3-benzodioxol-5-yl) methyl] piperazine-2-carboxamide; 1- (phenoxy) carbonyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(furan-2-yl) methyl] piperazin-2-acetamide; 1- (phenoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazine- 2-carboxamide; 1- (phenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazine- 2-carboxamide; 1- (phenoxy) carbonyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2- carboxamide; 1- (pyridin-3-yl) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol- 5-yl) ethyl] piperazin-2-acetamide; 1- (pyridin-3-yl) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; l- (pyridin-3-yl) carbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-) il) ethyl] piperazin-2-acetamide; 1- (pyridin-3-yl) ca rboni 1-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl ] piperazine-2-carboxamide; l- [2- (4-methoxyphenyl) ethyl] -4- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N-2- (3-chloro-4-methyl-phenyl) ethyl ] pipera zin-2 -carboxamide; 1- [2- (4-methoxy phenyl) ethyl] -4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol- 5-i 1) methyl] pipera zin-2-carboxamide; l- [2- (4-methoxyphenyl) ethyl] -4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol- 5-yl) methyl] piperazin-2-acetamide; 1- [2- (4-methoxy phenyl) ethyl] -4- [6-chloro- 2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benz odi) oxol-5-yl) useful] pipera zin-2-acetamide; 1- [2- (4-methoxyphenyl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazine-2-carboxamide; 1- [2- (4-methoxy phenyl) ethyl] -4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan -6-yl) methyl] piperazin-2-acetamide; l- [2- (4-methoxyphenyl) ethyl] -4- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) me useful ] pipera zin-2-carboxamide; l- [2- (4-methoxy phenyl) ethyl] -4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- [2- (4-methoxy phenyl) ethyl] -4 - [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl ] piperazine-2-carboxamide; l- [2- (4-methoxyphenyl) ethyl] -4- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] piperazin-2- carboxamide; 1- [(3,4-di-chloro-phenyl) -methyl] -carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) -pyrimidin-4-yl] -N- [2- (3 , 4-dimethoxy phenyl) ethyl] piper to zin-2-acet amide; 1- [(3,4-Dichlorophenyl) methyl] carbonyl-4- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methyl-enyl) -methyl] ] pipera zin-2-carboxamide; 1- [(3, 4- di chlorophenyl) methyl] carbonyl-4- [6-met il-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3-benzadioxol-5-yl) ethyl] piper a zin-2-acet amide; l - [(3,4-Dichlorophenyl) methyl] carbonyl-4- [6-chloro-2- (lH-imide zol-1-yl) pyr imi di n-4-yl] -N - [(3, 4 , 5-trimethoxy-f-enyl-) methyl] piperazine-2-carboxamide; 1- [(3,4-dichlorofenyl) met yl] carbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyr imi din-4-yl] - N - [(3, A -methyl phenyl) methyl] piper to zin-2-carboxamide; l - [(1, 3-benzodioxol-5-yl) methyl] carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3 , 4-dimethy phenyl) ethyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [3- (3,4-dime-to-phenyl) -propyl] -piperazine-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [3- (3,4-dimethoxyphenyl) propyl] piperazine-2-acetamide; l - [(1, 3-Benzodioxol-5-yl) methyl] carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5) -yl) methyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-i-sopropyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole -5-yl) ethyl] piperazin-2-acet amide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole -5-yl] piper a zin-2-acet amide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6- (1 H -imidazol-1-yl) pyrimidin-4- il] -N- [2- (1, 3-benzodioxol-5-yl) ethyl] pipe razin-2 -carboxamide; l- [(1, 3-Benzodioxol-5-yl) methyl] carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6) -Il) I piped zin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4 - methoxyphenyl) methyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4 -methoxypheneyl) methyl] piperazin-2-carboxamide; l- [(1, 3-Benzodioxol-5-yl) methyl] carbonyl-4- [6- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] ] pipera zin-2 -carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - (2-phenylcyclopropyl) ) piperazine-2-carboxamide; 1-methyl sulphonyl -4- [2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipe-razin-2 -carboxamide; N- [(3,4-dimethoxy-enyl) methyl] -1- [2- (1 H -imidazol-1-yl) pyrimidin-4-yl] pyrrole idin-2 -carboxamide; N- [(3,4-dimethoxy phenyl) methyl] -l- [2- (IH-imidazol-1-yl) pyrimidin-4-yl] pi r rol idin-2 -acet amide, • N- [(3 , 4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pi r rol i din-2 -acet amide; N- [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrole idin-2-acet amide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidin-2-acetarruda; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] pyrrolidin-2-acetamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(3-chloro-4-methoxyphenyl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidin-2-acetamide; N- [(3-chloro-4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N - [(4-methoxy phenyl) ethyl] -1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(3,4-dihydroxyphenyl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N-octyl-1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- (phenoxypropyl) -1- [2- (1H-imidazol-1-yl) -6-methyl-pyrimidin-4-yl] pyrrolidine-2-carboxamide; N - [(pyridin-3-yl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-y1] pyrrolidine-2-carboxamide; N- [(morpholin-4-yl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(2 (methoxypyridin-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidine-2-carboxamide; N- [(2 ( methylpyridin-5-yl) methyl] -1- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] piperidin-2-carboxamide; N- [(1,3-benzodioxol-5- il) ethyl] -2 - [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] acetamide; N - [(1,3-benzodioxol-5-yl) ethyl] ] -2 - [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2 - [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] acetamide; 2- [[- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] (methyl) ) amino] -N-octylacetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2 - [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] ( phenylmethyl) amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2 - [[2- (IH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2 - [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] [(l, 3 -benzodioxol-5-yl) methyl] amino] acetamide; N- [(3, 4-dimethoxyphenyl) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino} acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] [(morpholin-4-yl) ethyl] ] amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] (methyl) amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methylethyl) amino] acetamide; N- [(1, 3-benzodioxol-5-oxy) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [[4- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-2-yl] amino] acetamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -2 - [[4- (lH-imidazol-1-yl) -6-methylpyrimidin-2-yl] amino] acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -3 - [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] propionamide; 4- [(4-trifluoromethylphenyl) methyl] -3- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] propionamide; N - [(1,3-benzodioxol-5-yl) ethyl] -3- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] propionamide; N- [(1,3-benzodioxol-5-oxy) ethyl] -2- (lH-imidazol-1-yl) pyrimidinopyrimidin-4-amine; N- [(1,3-benzodioxol-5-yl) ethyl] -4- [1- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -1- (2-methyl-l- oxopropyl) piperazin-2-acetamide; N- [(4-methoxy phenyl) ethyl] -4- [2- (lH-imide zol-1-yl) -6-methylpyrimidin-4-yl) -6-methylpyrimidin-4-yl] -1- (2 -methyl-l-oxopropyl) piperidin-2-acetamide; N- [(4-nitrophenyl) methyl] -l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetamide; N- [[4- (acetylamino) phenyl] methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [[4- (Methylsul-fonyl-amino) -phenyl] -methyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetamide; N - [(2,3-dihydrobenzofuran-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetamide; N - [(indan-5-yl) methyl} -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-y1] piperidin-2-acetamide; N- [(3-chloro-4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4- (1-oxopropyl) piperazine-2-acetamide; N - [(4-methoxyphenyl) aminocarbonyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-methanamine; N- [(1,3-benzodioxol-5-yl) methylcarbonyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-methanamine; N- [(4-methoxyphenoxy) carbonyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl} piperidin-2-methanamine; N- [(4-methoxyphenyl) methylenedbonyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-methanamine; N- [(1,3-benzodioxol-5-yl) carbonyl] -1- [2- (lH-imidazol-1-yl) -6-met ilpyrimidin-4-yl] piper i din-2-et anamine; 2,4-bis (lH-imidazol-1-yl) -6-methylpyrimidine; N- [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -5-methylpyrimidin-4-yl] -4- (f -methylmethyl) piperazin- 3 -acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -6- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N-methyl-5,6,7,8-tetrahydropyrido [5, 6-c] pyrimidin-4-amine; 2- [[2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] amino] -N - [(1,3-benzodioxol-5-yl) methyl] -4-methylthiobutanamide; 2- [[2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-y1] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] -4-methylthiobutanamide; 2- [[2- (1 H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] amino] -N - [(4-methoxy phenyl) methyl] -4-methylsulfonylbutanamide; 2- [[2- (1 H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (butylthio) butanamide; 2- [[2- (1 H-imidazol-1-yl) -6-me t -pyrimidin-4-yl] amino] -N - [(cyclopropyl) methyl] -3 - [(3,4-dimethylphenyl) methylthio] ] propanamide; 2- [[2- (1 H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N - [(2,5-dimethoxyphenyl) ie] 3-me ti 1 -3- [(f-enylmethyl) thio] butanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(4-chlorophenyl) methyl] -3-thiofenpropanamide; - [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N - [(1,3-benzodioxol-5-yl) methyl] pentanamide; 5- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,4-benzodioxol-6-yl) ethyl] pentanamide; 7- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] amino] -N- [2-phenylcyclopropyl) heptanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] - [(3-chloro-4-methoxyphenyl) ethyl] acetamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] acetamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,4-benzodioxan-6-yl) ethyl] acetamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] amino] -N- [(4-methoxyphenyl) ethyl] acetamide; 4- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] butanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(4-chlorophenyl) ethyl] pyridine-3-propanamide; 2- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] isoquinoline-3-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] piperidin-2-acetamide; 1- [2- (IH-imidazol-1-yl) -6-methylpyrimidin-4-y1] - N - [(4-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperidin-2-acetamide; 1- [2- (IH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- [(4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(2,4-dimethoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] piperidin-2-acetamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] thiomorpholin-2-acetamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] thiomorpholin-2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (iH-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) methyl] piperazine-2 -acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N - [(1,3-benzodioxol-5-yl) methyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- [(1,3-benzodioxol-5-yl) ethyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (IH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] piperazine-2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4 -i 1] - N - [(3,4-dimethoxy phenyl) methyl] piperazine -2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] pyrimidine-3-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] pyrimidine-3-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] pyrimidine-3-carboxamide; 1- [2- (1H-imide zol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] pyrimido 3-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] pyrimidine-3-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-chloro-4-methoxy phenyl) methyl] pyrimidin-3-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperidin-3-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] piperidin-3-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperidin-3-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] piperidin-3-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperidin-3-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] piperidin-3-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(2,4-dimethoxyphenyl) methyl] piperidin-3-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperidin-3-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] pyrrolidine-2-carboxamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] pyrrolidine-2-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N - [(4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] -N- [(1,3-benzodioxol-5-yl) ethyl] acetamide; 1- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] -N - [(1,4-benzodioxan-6-yl) ethyl] acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4-methylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4-methylpiperazin-2-acetamide; l- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] - N - [(4-chlorophenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) ethyl] -4-methylpiperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] -4-methylpiperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,5-dimethoxyphenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4-methylpiperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-methoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(2-methoxyphenyl) methyl] -4-methylpiperazine-2-carboxamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-methoxyphenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-pyrimidin-4-yl] -N- [[4- (2-methoxyethoxy) phenyl) methyl] -4-methylpiperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4-methylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(indal-5-yl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4-butylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4-butylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4-butylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-butylpiperazine-2-carboxamide; 1- [2- (1 H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; l [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2- acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- [(4-methoxyphenyl) methyl] piperazine- 2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(4-methoxyphenyl) methyl] ] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(4-methoxyphenyl)] methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(4- methoxyphenyl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- [(4-methoxy phenyl) methyl] piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4 - [(4-methoxyphenyl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- [(4-methoxyphenyl) methyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazine- 2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-trif luor ome thi-pyrimidin-4-yl] -N- [(2-f-enyl-cyclopropyl) -4- [(4-methoxy-enyl) -methyl]] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2 -acetamide; 1- [6-Chloro-2- (1H-imidazol-1-yl) -pyridin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(3,4-dichlorophenyl) methyl] piperazine -2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(3,4-di) chloro phenyl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4 - [(3,4-dichlorophenyl)] methyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-ben z odi oxan-6-yl) methyl] -4- [(3 , 4-di chloro or phenyl) ethyl] pipera zin-2 -acetamide; l- [2- (lH-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(3, 4 - dichlorofenyl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benz odi oxan-6-yl) ethyl] -4 - [(3,4-dichlorophenyl) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- [(3,4-dichlorophenyl) methyl] piperazine -2-acetamide; l- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- [(1,3-benzodioxole -5- i 1) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzooxyol-5-yl) methyl] -4- [(1,3-benzodioxol-5 -yl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(1, 3- benzodioxol-5-yl) ethyl] piper a zin- 2 -acet amide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) ethyl] -4 - [(1,3-benzodioxol-5- il) methyl] pipera zin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(1, 3- benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(1, 3- benzodioxol-5-yl) methyl] piperazin-2 -acetamide; 1- [2- (lH-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] - A - [(1, 3- benzodioxol-5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4 - [(1,3-benzodioxol-5- il) methyl] piperazin-2 -acetic acid; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- [(1, 3- benzodioxol-5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- [(1,3-benzodioxol-5- il) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4 - [(1,3-benzodioxol -5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(1,4-benzodioxan-6 il) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-i1] -N- [(4-methylphenyl) methyl] -A- [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(3,5-dimethoxy phenyl) methyl] -4- [(1,4-benzodioxan- 6-yl) ethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(1,4-benzodioxan -6-yl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] - A - [(1, 4- benzodioxan-6-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imide zol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(1,4-benzodioxan-6-yl) ) methyl] piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(1,4-benzodioxan-6-yl) methyl] pipe -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4 -i 1] -N- [(3-methoxyphenyl) ethyl] -4- [(1,4-benzodioxan-6-yl) ) methyl] piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2-thiophenyl) ethyl] -4- [(1,4-benzodioxan-6-yl) methyl] piperazine- 2-acetamide; 1- [2- (1 H-imidazol-1-yl) -6-trif luor ome t ilpyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) methyl] -4- [(1, 4- benzodioxan-6-yl) methyl] piperazin-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1-adamantyl) methyl] -4- [(1,4-benzodioxan-6-yl) methyl] ] piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(5-indanyl) methyl] -4- [(1,4-benzodioxan-6-yl) methyl] piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- [(pyridin-3-yl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) propyl] -4- [(pyridin-3-yl) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazin-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(pyridin-3-yl) ) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4 - [(pyridin-3- il) methyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(pyridin-3- il) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridin-3-yl) ) methyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridine- 3-yl) methyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridin-3- il) methyl] piperazin-2-acetamide; l- [2- (lH-im? dazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridin-3-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridin-3-yl) ) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine -2 -acetamide; 1- [2- (1H-imide zol-1-yl) -6-me t -pyrimidin-4-yl] -N- [(4-me-to-phenyl) -methyl] -4- [(pyridin-3-yl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxy phenyl) methyl] -4- [(pyridin-3-yl) methyl] pipera zin-2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,6-dimethoxy phenyl) methyl] -4- [(pyridin-3- il) methyl] pipera zin-2-carboxamide; l- [2- (IH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- [(pyridin-3- il) methyl] pipe razin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(3-f luoro -4-methoxyphenyl) -methyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(3-f luoro -4-methoxyphenyl) -methyl] piperazin-2-acet amide; 1- [2- (1H-imidazol-1-yl) pyrimin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(3-fluoro-4-methoxyphenyl) ) -methyl] pipera zin-2 -acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(3-fluoro- 4-methoxyphenyl) -methyl] piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 4-benzodioxan-6-yl) ethyl] -4- [(3-fluoro-4-methoxyphenyl) -methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- [(3-f luoro-4-methoxy phenyl) methyl] piperazine -2-acetamide; 1- [2- (lH-imide zol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- [(3-f luoro-4-methoxy phenyl) ) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- [(3-f luoro- 4 -me toxy phenyl) ) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(l-adamantyl) methyl] -4- [(3-f luoro-4-methoxy phenyl) methyl] pipera zin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4- [(3-f luoro-4-methoxy-enyl) methyl] pipera zin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-Imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4-acetylpiperazin-2-acetarruda; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(4-methylphenyl) methyl] -4-acetylpiperazine-2-acetarruda; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methylphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-1] - N - [(4-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(3,5-dimethoxyphenyl) ethyl] -4-acetylpiperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4-acetylpiperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4-acetylpiperazin-2- acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4,5-trimethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-acetylpiperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] - N - [(4-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-methoxyphenyl) ethyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-difluorophenyl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-phenylcyclopropyl) -4-acetylpiperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(indal-5-yl) methyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] - A - (3-methyl-1-oxobutyl) piperazine-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acculent; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (3-methyl-1-oxobutyl) ) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (3-methyl-l-oxobutyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (3-methyl-1-oxobutyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (3-methyl-1) -oxobutyl) piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- (3-methyl-l-oxobutyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -A- (3-methyl) -1-oxobutyl) piperazine-2-carboxamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (3-methyl-1-oxobutyl) pipera zin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (3-methyl-1-oxo-butyl) pipera zin-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (3-met i 1 -1-oxobutyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (3-methyl-l-oxobutyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (3-methyl-1 -oxobutyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (3-methyl-1) -oxobutyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (3-methyl-1-oxo-butyl) -piperazin-2- acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] - N - [(3-methoxyphenyl) methyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (3-methyl-1-oxo-butyl) -piperazine-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [([4- (2-methoxyethoxy) phenyl) ethyl] -4- (3-methyl-1-oxobutyl) pipera zin-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-2-yl) ethyl] -4- (3-methyl-1) -oxobutyl) piperazin-2-acetamide; 1- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-phenylcyclopropyl) ethyl] -A- (3-methyl-l-oxobutyl) piperazine-2-carboxamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxy phenyl) methyl] -4- (3-met il-1-oxobutyl) pipera zin-2-acetamide; 1- [2- (1 H-imidazol-1-yl) pyrimidin-4-yl] -N- [(indal-2-yl) ethyl] -A- (3-methyl-l-oxobutyl) piperazin-2- carboxamide; 1- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (indal-5-yl) ethyl] -4- (3-met il-1-oxobutyl) pipe razin-2 -ace ago; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) ) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (2-methoxy-l-oxoethyl) ) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) piperazine -2-acetamide; l- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] -N- [(4-ethoxyphenyl) ethyl] -A- (2-methoxy-l-oxoethyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-1] - N - [(4-ethoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) piperazin-2 acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (2-methoxy-l-oxoethyl) piperazin-2 -acetamide; 1- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] - N - [(4-chlorophenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazine-2 -acculent; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazin-2- acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (2-methoxy-1-oxoethyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (IH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (2-methoxy-1-oxoethyl) ) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-methoxy-1) -oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-methoxy-l- oxoethyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-methoxy) -1-oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- (2-methoxy-l-oxoethyl) piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy-1) -oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy-l- oxoethyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy) -l-oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy-l-oxoethyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (2-methoxy-1) -oxoethyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (2-methoxy-1- oxoethyl) piperazin-2-acetamide; 1- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2-methoxy-l-oxoethyl) piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazin- 2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazine -2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- (2-methoxy-l-oxoethyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) piperazine-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- (2-methoxy-1-oxoethyl) ) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(indal-5-yl) methyl] -4- (2-methoxy-1-oxoethyl) piperazine -2-acetamide; 1- [2- (1 H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (tetrahydro-3-) furanoyl) pipera zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) propyl] -4- (tetrahydro-3-furanoyl) pipera z in-2-acetamide; l- [2- (lH-imide zol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(4-ethoxy phenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) ethyl] -A- (tetrahydro-3-furanyl) piperazine-2 -acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-methylphenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-y1] -N- [(4-methyl phenyl) methyl] -4- (tetrahydro-3-furanyl) piperazine-2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methyl phenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2-acetamide; 1- [2- (IH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (tetrahydro-3-furanyl) piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-met i lpyr imidin-4-yl] - N - [(4-chlorophenyl) methyl] - (4-tetrahydro-3-furanoyl) piperazin- 2 -acetamide; l- [2- (lH-imide zol-1-yl) -6-met-il-pyrimidin-4-yl] -N- [(4-chlorophenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2- acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-methoxy-3-chlorophenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazine- 2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (tetrahydro-3-furanoyl) ) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (tetrahydro-3-furanoyl) piperazine -2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-di methylphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) pir imidin-4-yl] -N- [(pyridin-3-yl) methyl] -4- (tetrahydro-3-furanoyl) pipera zin-2 -carboxamide; 1- [2- (1H-imide zol-1-yl) -6- (methyl ethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- ( tetrahydro-3-furanoyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (tetrahydro-3-furanoyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (tetrahydro-3-furanyl) piperazine-2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-phenyl) -ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2- acetamide; 1- [2- (1 H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N - [(3-methoxyphenyl) ethyl] -4-tetrahydro-3-furanoyl) piperazine-2-acetamide; 1- [2- (lH-imide zol-1-yl) pyr imidin-4 -i 1] - N - [(3,4-di fluorophenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl)? irimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,5-di methoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) butyl] -4- (2-carboxymethoxy-1-oxoethyl) piperazin-2-acetamide; l- [6-Chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (2-carboxymethoxy-1) -oxoethyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- (2-carboxymethoxy-l- oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-y1] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-carboxymethoxy-l-oxoethyl) ) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-carboxymethoxy-l) -oxoethyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (2-carboxymethoxy-1) -oxoethyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazine-2- acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazine-2 -acetamide; l- [6- (lH-imi azol-l-yl) pyrimidin-4-yl] -N - [(2,4-dimethoxyphenyl) methyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazin-2- carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(2,6-dimethoxyphenyl) methyl] - A - (2-carboxymethoxy-1-oxoethyl) ) piperazin-2-carboxamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,6-dimethoxyphenyl) methyl] -4- (2-carboxymethoxy-1-oxoethyl) piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3, 4-dimethoxyphenyl) ethyl] -4- (2-phenoxy-1-oxoethyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) propyl] -4- (2-phenoxy-1-oxoethyl) pipera zin-2 -carboxamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-phenoxy-l) -oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-phenoxy-l) -oxoethyl) piperazin-2-acetamide; 1- [2- (1 H-imidazol-1-yl) -6-trif luoromet-ilpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- (2-phenoxy-1-oxoethyl) ) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met-il-pyrimidin-4-yl] -N- [(4-me-toxi-phenyl) -methyl] -4- (2-phenoxy-1-oxoethyl) pipera zin-2 -acet amide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxy phenyl) methyl] -4- (2-phenoxy-1-oxoethyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxy phenylethyl] -4- (pyridin-3-ylcarbonyl) pipera zin-2 -acetamide; l- [2 (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazin-2- acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) propyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) util] -4- (pyridin-3-ylcarbonyl) piperazin -2-acetamide; l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (pyridine-3 ilcarbonyl) piperazin-2-acetamide; l- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] -N- [(4-methyl phenoxy) ethyl] -4- (py idin-3-ylcarbonyl) piperazin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-met i lpyr imidin-4-yl] -N- [(4-met i 1 phenoxy) methyl] -4- (pyridin-3-ylcarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) met il] -4- (pyridin-3-ylcarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (pyridin-3-ylcarbonyl) ) piperazin-2-acetamide; l- [2- (lH-imide zol-1-yl) -6-met i lpyr imidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (pyridin-3-) ilcarbonyl) pipera zin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(2,5-dimethoxy phenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazin-2 -carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (pyridin-3-ylca rbonyl ) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazine- 2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (pyridin-3-ylcarbonyl ) piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(2,5-dimethylphenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine- 2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (pyridin-3-ylcarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (pyridin-3-ylcarbonyl ) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (pyridine-3 -carbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met-ilpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine-2 -acetamide; l- [2- (1 H- imidazol-1-yl) -6-met i lpyr imidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -A- (pyridin-3-ylcarbonyl) piperazin-2 -acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-methoxyphenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (pyridin-3-ylcarbonyl) pipera zin- 2 -acet amide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(2-thienyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-carboxamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-di fluorophenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] -piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] - 4- (2- (4-methoxyphenyl) -1-oxoethyl] piperazine-2-carboxamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [( 4-methoxy-3-chlorophenyl) methyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] -piperazin-2-acetarruda; 1- [2- (lH-imidazol-1-yl) -6- methylpyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) methyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] -piperazin-2-acetamide; l- [2- ( lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-methoxy-3-chlorophenyl) methyl] -4- (2- (4-methoxyphenyl) -l-oxoethyl] piperazine-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,5-dimethoxy phenyl) ethyl] -4- (2- (4-methoxy-phenyl) -1 -oxoethyl] piperazin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-trif luoromethylpi rimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ) ethyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(3,4-dimethyl phenyl) methyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazole-1- il) pyrimidin-4-yl] -N - [(3,4-dimethyl-yl-enyl) methyl] -A- (2- (4-methoxy-phenyl) -1-oxo-ethyl] -piperazine-2-acetamide; 1- [ 2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethyl-phenyl) -ethyl] -4- (2- (4-methoxyphenyl) - 1-oxoethyl] -piperazin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-trif luoromet-ilpyrimidin-4-yl] -N- [(3-pyridinyl) methyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] piperazin-2-carboxamide; l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1 , 4-benzodioxan-6-yl) methyl] -4- (2- (4-methoxyphenyl) - 1 -oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1, 4-benzodioxan-6-yl) methyl] -4- (2- ( 4-methoxy phenyl) -1-oxoethyl] -piperazin-2-acet amide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl ] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- ( 2- (4-methoxyphenyl) -1-oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [( 3-methoxyphenyl) ethyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] - N- [(2-thienyl) ethyl] -4- (2- (4-methoxyphenyl) -l-oxoethyl] piperazine-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4- il] -N- [(l-methylpyrrol-2-yl) ethyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] piperazine-2-carboxamide; l- [6-chloro-2- ( lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxy phenyl) methyl] -4- (2- (4-methyl-phenyl) -1-oxoethyl] pipera zin -2-acetamide: 1- [2- (1H-imidazol-1-yl) -6-trif luoromet-ilpyrimidin-4-yl] -N- [(3,4-di-methoxyphenyl) methyl] -4- (2 - (4-methoxyphenyl) -l-oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (2- (1,3-benzodioxol-5 -yl) -1-oxoethyl] piperazin-2-carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (2- (1,3-benzodioxol- 5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piper to zin-2 -acet amide; 1- [6-chloro-2- (lH-imidazol-1-yl) - 6- (Methylethyl) pyrimidin-4-yl] -N- [(2-methoxy phenyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazine-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] - A - (2- (1,3-benzodioxol-5-yl) -1 -oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (2- (1, 3 -benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4 chlorophenyl) methyl] - A - (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl ) pyrimidin-4-yl] -N- [(4-chlorophenyl) ethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [2 - (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (2- (1,3-benzodioxol-5- il) -1-oxoethyl] pipera zin-2-acet amide; 1- [2- (1 H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) ethyl] -4- (2- (1, 3 -benzodioxol-5-yl) -1-oxoethyl] piperazin-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3 -benzodioxol-5-yl) methyl] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-imidazole -l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2- ( 1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4 -dimethylphenyl) ethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) ) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] pipera zin- 2 -acetamide; 1- [2- (lH-imidazol-1-yl) pyrimin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (2- (1, 3-benz Hatexol-5-yl) -1-oxoethyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) ) -1-oxoethyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxy-enyl) -methyl] -4- [2- (1,3-benzodioxole-5 -yl) -1-oxoethyl] piperazin-2 -acetamide; 1- [2- (lH-imidazol-1-yl) -6-trif luoromet-ilpyrimidin-4-yl] -N- [(3-methyl-phenyl) -ethyl] -4- (2- (1,3-benzodioxol) -5-yl) -l-oxoethyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl ) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazine-2-acetamide; l- [2 - (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (2- (1,3-benzodioxol-5) -yl) -1-oxoethyl] piperazin-2 -aceta-1- (2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3, 4 -di ethoxyphenyl) methyl] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6 -methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenylmethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [2 - (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(2-indanyl) met il] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- (2- (1,3-benzodioxol-5- il) -1-oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N- [(4-methylphenyl) methyl] -4- (methylsulfonyl) piperazine-2-acetamide; l- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [ (4-chlorophenyl) methyl] -4- (methylsulfonyl) piperazine-2-acetamide; l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4- methoxy-3-chlorophenyl) methyl] -4- (methylsul fonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [( 1,3-benzodioxol-5-yl) methyl] -4- (methylsulfonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1) , 3-benzodioxol-5-yl) methyl] -4- (methylsulfonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-6-yl) methyl] -4- (methylsu) lfonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-6-yl) ethyl] -4- (methylsulfonyl) piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-6-yl) ethyl] -4- (methylsulfonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (methylsulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazin-2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazin-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (methylsulfonyl) piperazine-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-methoxyphenyl) ethyl] -4- (methylsulfonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (methylsulfonyl) piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (methylsulfonyl) piperazin-2- acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (methylsulfonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (octylsulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] -4- (octyl sulphonyl) piperazine- 2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) ethyl] -4- (octyl sul phonyl) pipera zin -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] -4- (octylsulfonyl) piperazine -2-acetamide; l- [2- (IH-imidazol-1-yl) -5-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (octylsulfonyl) piperazin-2- acetamide; 1- [2- (IH-imidazol-1-yl) pyrimin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (octylsulfonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4- (octylsulfonyl) piperazin-2 -acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (octylsulfonyl) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (octylsulfonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (octylsulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] -4- (octylsulfonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] - A - (dimethylaminosul fonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethylpyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (dimethylaminosulfonyl) piperazin-2- acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (dimethylaminosulfonyl) piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazin-2 -acetamide; l- [2- (lH-imidazol-l-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazine-2- acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4- (dimethylaminosulfonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] - A - (dimethylaminosulfonyl) piperazin-2 acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (dimethylaminosulfonyl) piperazine -2-carboxamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- (dimethylaminosulfonyl) piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- (dimethylaminosul fonyl) pipera zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (dimethylaminosul fonyl) pipera zin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- (dimethylaminosulfonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-2-yl) methyl] -4- (dimethylaminosulfonyl) piperazine-2 -carboxamide; l- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N - [(2,3-di methoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-di methoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (dimethylaminosulfonyl) piperazin- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3,5-dimethoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N - [(2-adamantyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-carboxamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(2,3-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (propylaminocarbonyl) pipera zin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N - [(3,4-dimethoxy phenyl) ethyl] -4- (propylaminocarbonyl) pipera zin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-di methoxyphenyl) propyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3, 4-di methoxyphenyl) butyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxy-phenyl) -methyl] -4- (propylaminocarbonyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -A- (propylaminocarbonyl) p i pera z-2-acet amide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-methylphenoxy) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-pyrimidin-1-yl] - N - [(4-methylphenoxy) ethyl] -4- (propylaminocarbonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-y1] - N - [(4-chlorophenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imide zol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(3-cl-4-methyl-to-phenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] -4- (propylaminocarbonyl) -piperazin-2 -acetamide; l- [2- (lH-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(3-chloro-4-methyl-phenyl) ethyl] -4- (propylaminocarbonyl) piperazine -2-acetamide; 1- [6-chloro-2- (1 H-imidazol-1-yl) pyrimidin-4-y1] -N- [(3-cl-oro-4-methyl-phenyl) -ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imide zol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-me toxy phenyl) ethyl] -A- (propylaminocarbonyl) pipera zin-2 -acet amide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imide zol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (IH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (propylaminocarbonyl) piperazin-2- acetamide; 1- [(2- (1H-imide zol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4 - (propylaminocarbonyl ) pipe razin-2 -acet amide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (propylaminocarbonyl) piperazine-2- acetamide; 1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [. (1,3-benzodioxol-5-yl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imide zol-1-yl) pyrimin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (propylaminocarbonyl) piperazine-2-carboxamide; l- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethylphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminocarbonyl) piperazine -2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminocarbonyl) piperazin-2 acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminocarbonyl) piperazine-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (propylaminocarbonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (propylaminocarbonyl) piperazin-2- acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminocarbonyl) piperazine -2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl-4- (propylaminocarbonyl) piperazine-2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -A- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(2-methoxyphenyl) ethyl] - A - (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] - N - [(2-thienyl) ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-thienyl) ethyl] -4- [propylaminocarbonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-difluorophenyl) ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) -pyridin-4-yl-N- [(1,4-benzodioxan-2-yl) methyl] -4- (propylaminocarbonyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] -4- (propylaminocarbonyl) piperazin-2 acetamide; 1- [2- (1 H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-y1] -N - [(1,4-benzodioxan-2-yl) methyl] -4-propylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(2,5-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxy phenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1 H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4 (propylaminocarbonyl) piperazine-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [3,4-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imide zol-1-yl) -6-met ilpyr imidin-4-yl] -N- [3,4-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,5-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,5-dimethoxy phenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-pyrimidin-4-yl] -N- (cyclopropyl) -4- (propylaminocarbonyl) piperazin-2 -acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- (2-indanyl) -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(5-indanyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imide zol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [2- (1H-Imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- (cyclohexylaminocarbonyl) pi? Erazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazin-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] - N - [(4-chlorophenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-Imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (cydohexylaminocarbonyl) piperazine-2 -acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2 -acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2- acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] - A - (cyclohexylaminocarbonyl) pipera zin-2 -acet amide; l- [2- (lH-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (cyclohexylaminocarbonyl) pipera zin - 2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -A- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-methoxyphenyl) ethyl] - A - (cyclohexylaminocarbonyl) piperazin-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(2-methoxyphenyl) ethyl] - A - (cyclohexylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-difluorophenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(2,5-dimethoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (cydohexylaminocarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl-4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- (2-indanyl) -4- (cyclohexylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4- (phenylsulfonylaminocarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (phenylsulfonylaminecarbonyl) piperazine-2 -acetamide; l- [5-Chloro-2 (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (phenylsulfonylaminocarbonyl) piperazine-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4- (phenylsulfonylaminocarbonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-pyrimidin-4-yl] - N - [(2,3-di-metoxyphenyl) methyl] - A - (phenylaminocarbonyl) piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) propyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] - N - [(4-methylphenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(4-chlorophenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; l ~ [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) ethyl] -4- (phenylaminocarbonyl) piperazine-2-carboxamide; l- [6-Chloro-2- (lH-imidazolo-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-pyrimidin-4-yl] -N - [(3-chloro-4-methoxy-phenyl-1-yl) -yl] -4- (phenylaminocarbonyl) piperazine-2 -carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) ethyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (phenylaminocarbonyl) piperazine-2 -acetamide; l- [2- (lH-imidazol-l-yl)? irimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (phenylaminocarbonyl) pipera zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (phenylaminocarbonyl) piperazin-2- acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (phenylaminocarbonyl) piperazine-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (phenylaminocarbonyl) pipera zin-2 -acet amide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] -N- [(3-methoxyphenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2 -acet amide; l- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (phenylaminocarbonyl) pipe razin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (phenylaminocarbonyl) piperazin-2-acet amide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (phenylaminocarbonyl) piperazin-2-acet amide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl-N- [(3-thienyl) ethyl] -4- (phenylaminocarbonyl) piper a zin-2-acet amide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-difluorophenyl) methyl] -A- (phenylaminocarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazolo-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1 H-imidazol-1-yl) -6- (methylethyl) pyrimidin- -i 1] - N - [(3,4-dimethoxy phenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2 -acetamide; l- [6- (1H-imdidazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-carboxamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- (phenylaminocarbonyl) piper a zin-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimido-4-yl] -N- [(2,3-dimethoxy phenyl) ethyl] -4- [(4-methoxy phenyl) aminocarbonyl] pipera zin -2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,3-dimethoxyphenyl) ethyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine-2-carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine- 2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] - N - [(4-methoxyphenoxy) ethyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2- carboxamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] - A - [(4-methoxyphenyl) aminocarbonyl] piperazine -2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4 - [(4-methoxy-phenyl) aminocarbonyl] piperazin-2-acet amide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) ethyl-4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(2,5-dimethoxyphenyl) ethyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-carboxamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] - 4 - [(4 -methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4 - [(4-methoxyphenyl) aminocarboni lpiper to zin-2-carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(1,3-benzodioxol-5-yl) ethyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazin-2 -acetic acid; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(3,4-dimethyl-yl-enyl) methyl] -4- [(4-methoxy-phenyl) -aminocarbonyl]] piperazin-2-acetamide; l-6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethylphenyl) methyl] -4- [(4-methoxy phenyl) aminocarbonyl] piper a zin-2 - acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2-furyl) methyl] -4- [(4-methoxy phenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (4-methoxyphenyl) aminocarbonyl] pipe razin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] - A - [(4-methoxyphenyl) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4 - [(4-methoxyphenyl) aminocarbonyl] pipera zin -2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2- acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) ethyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1, 4-benzodioxan-2-yl) ethyl] -4 - [(4 - methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [5-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,3-dimethoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine- 2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(2,5-dimethoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2 -acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (2-indanyl) -4- [(4-methoxyphenyl) aminocarbonyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(5-indanyl) methyl] -4- [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) propyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazin-2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) butyl] - A - [(3,4-dichlorophenyl) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) ethyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4- [(3,4-dichlorophenyl) aminocarbonyl] piperazine-2 -acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazine- 2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-i1] -N - [(4-methylphenyl) methyl] -4- [(3,4-dichlorophenyl) aminocarbonyl] piperazine-2 -acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4 - [(3, -dichlorophenyl) aminocarbonyl] piperazin-2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -A- [(3,4-dicyclophenyl) aminocarbonyl] piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- [(3,4-dichlorophenyl) aminocarbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) methyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazine- 2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -A - [(3,4-dichlorophenyl) aminocarbonyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-y1] -N- [(1,3-benzodioxol-5-yl) methyl] -4 - [(3, A-dichlorophenyl) aminocarbonyl] piper to zin-2-acet amide; l- [2- (lH-imidazol-l-yl) -6-met ilpyr imidin-4-l-N- [(1,3-benzodioxol-5-yl) methyl] -4 - [(3, 4 - dichlorophenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] -4 - [(3, A -dichlorophenyl) aminocarbonyl] pipera zin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4 - [(3, 4 - dichlorophenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazin-2-acet amide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl-N- [(3,4-dimethylphenyl) methyl] -A - [(3,4-dichlorophenyl) aminocarbonyl] pipe ra zin- 2 -ace tarruda; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] pipera zin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] - A - [(3, 4 - dichlorophenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4 - [(3, A - dichlorophenyl) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(3,4-dichlorophenyl) aminocarbonyl] piperazine-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(3,4-dichlorophenyl) aminocarbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- [(3,4-dichlorophenyl) aminocarbonyl] piperazine-2 -acetamide; l- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(2,5-dimethoxyphenyl) methyl] - A - (3,4-dichlorophenyl) aminocarbonyl ] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -A - [(3,4-dichlorophenyl) aminocarbonyl] pipera zin-2-acetarruda; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -A - [(3,4-dichlorophenyl) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] - A - [(3, A-dichlorophenyl) aminocarbonyl] piper a zin- 2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] -A- (methoxycarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (methoxycarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetarruda; l- [6-chloro-2- (IH-imidazol-1-yl) pyrimidin-4-yl-N- [(3-chloro-4-methoxy phenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methyl-pyrimidin-4-yl-N- [(3-chloro-4-methoxy phenyl) ethyl] -A- (methoxycarbonyl) piperazine-2- acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (methoxycarbonyl) pipera zin- 2 -ace ago; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N [(1,3-benzodioxol-5-yl) ethyl] -4- (methoxycarbonyl) piper a zin- 2- acetylamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl-4- (methoxycarbonyl) piperazine-2- acetamide; 1- [2- (1 H-imidazol-1-yl) pi r imidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (methoxycarbonyl) piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (methoxycarbonyl) piperazine-2 -acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methoxycarbonyl) piperazin-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (methoxycarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (methoxycarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (methoxycarbonyl) piperazine-2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] -4- (methoxycarbonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(3,4-dimethoxy phenyl) methyl] -4 - (methoxycarbonyl) piperazin-2 acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (meth i letoxy carboni l ) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] -4- (methylethoxycarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (butoxycarbonyl) pipera zin-2 -acetamide; l- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl-N- [(1,4-benzodioxan-6-yl) methyl] -4- (butoxycarbonyl) piperazine-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6-me-t-ylpyr-imidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (butoxycarbonyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (butoxycarbonyl) piperazin-2-acet amide; 1- [2- (1 H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-difluorophenyl) methyl] -4- (butoxycarbonyl) pipera zin-2 -carboxamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazin-2- acetamide; 1- [2- (1H-imide zol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-chloro-4-methyl-phenyl) -methyl] -4- [(2-methoxyethoxy ) carbonyl] piper to zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] -4 - [(2 - methoxyethoxy) carbonyl] pipe razin-2-acet amide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(2-methoxyethoxy) carbonyl] ] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(2-methoxyethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(2-methoxyethoxy) carbonyl] ] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- [(2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -5-methylpyrimidin-4-yl-N- (1,4-benzodioxan-6-yl) ethyl] -4- (2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazine-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] -4 - [(2-methoxyethoxy) carbonyl] piperazine-2 -acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- [(phenylmethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imi azol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- [(phenylmethoxy) carbonyl] piperazine-2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(phenylmethoxy) carbonyl] piperazin-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] - A - [(phenylmethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(phenylmethoxy) carbonyl] piperazine -2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-i 1] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(phenylmethoxy) carbonylpiperazine -2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- [(phenylmethoxy) ca rbonyl] piperazine-2 -carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(phenylmethoxy) carbonyl] piperazine-2-acetamide; l- [6-Chloro-2- (2 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazin-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl-N - [(4-methoxy phenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazin-2-acetamide; 1- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- [(phenylmethoxy) carbonyl] piper a zin-2-acet amide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-di-methoxyphenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazine-2- acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pir imidin-4-yl-N - [(3,4-di methoxyphenyl) ethyl] -4- [(phenylme toxy) carbonyl] piperazin -2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-di methoxyphenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazine -2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] -4- [(1-methylpropoxy) carbonyl] pipera zin -2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) etii] -4- [(1-methylpropoxy) carbonyl] piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-i 1] -N- [(4-methoxyphenyl) methyl-4- [(1-methylpropoxy) carbonyl] piperazine- 2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4 - [(4-methoxy phenoxy) ) carbonyl] pipera zin-2 -carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3, 4, 5-trimethoxyphenyl) methyl] -4 - [(4-methyl) phenoxy) carbonyl] ipera zin-2 -acet amide; 1- [2- (1 H-imidazol-1-yl) -6-trif luo romet i lp ir imi din-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4 - [(4-methoxyphenoxy) carbonyl] piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- [(4-methoxyphenoxy) carbonyl] ] piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- [(-methoxy phenoxy) carbonyl] piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1-methylpyrrol-2-yl) ethyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine -2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,4-dimethoxyphenyl) methyl] -4 - [(4-methoxyphenoxy) carbonyl] piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,6-dimethoxyphenyl) methyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine- 2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine-2 -carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylethylpyrimidin-4-yl-N- [1- (phenylimethyl) piperidin-4-yl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1-cyanocyclohexyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- (2, 2-dimethoxyethyl) piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N-tridecylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-hydroxy-4-methylthiobutyl) piperidin-2-acetard; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N, N- [bis (2-cyanoethyl)] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N, N- [bis (2-cyanomethyl)] piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N - [(4,4-diethoxybutyl) piperidin-2-acetamide; l- (4-fluorophenyl) -4- [l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] piperazine; l- [(1, 3-Benzodioxol-5-yl) methyl] -4- [l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] piperazine; 1- (phenylmethyl) -4- [1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -piperidin-2-acetyl] piperazine; 4- [1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] piperazine-1-carboxylic acid ethyl ester, 1- (4-chlorophenyl) -4- [1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] -4-hydroxypiperidine; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(2,3-dihydrobenzofuran-5-yl) methyl) piperidin-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? Dm-4-? L] -N- [(mdan-5-? L) methyl) piper? dm-2 -acerate; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? D? N-4-? L] -N- [(cyclohexyl) methyl] pipe ndm- 2 - ace tarruda; 1- [2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? L] -N- [(1,2,3,4-tetrah? Dronaftalen-1- ? l) piper? d? n-2 -acetarr; l- [2- (lH-? m? dazol-l-? l) p? pm? dm-4-? l] -N- [(aftalen-1-yl) methyl) pipe pdm- 2 -aceterate; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M? Dm-4-? L] -N- [(1,3-benzod? Oxol -5-? L) methyl] p? Per? Dm-2-acetam? Da; 1- [(2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? Pm? D? N-4-? L] -N- [(4-chlorophen? L) methyl] pipe pdin-2 -acet amide; l- [2- (lH-? m? dazol-1-? l) -6-met? let? lp? r? m? dm-4-? l] -N - (2-et? Lhex? L) pipe pdm- 2 -ace taarruda; l- [2- (lH-? M? Dazol-l-? L) p? R? M? D? N-4-? ] -N- (2-ethylhexyl) pipe ridm- 2 -acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? Dm-4-? ] -N- (2-ethylhexyl) p ipe r? Dm-2-acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M ? dm-4-? l] -N- [2- (morpholm-4-? l) et? l] p? per? d? n-2-acetam? da; 1- [2- (lH-? m ? dazol-1-? l) -6-met? lp? r? m? dm-4-? l] -N- (1-methylhexyl) piper? dm-2-acet amide; 1- [2- (lH -? m? dazol-1- l) -6-met? let? lp? pm? d? n-4-? l] -N- (1-met? lhex? l) p? per? dm-2- acetam? da; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (l-methylhexyl) piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(2-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] - N - [(4-methoxyphenyl) methyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (cyclooctyl) piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1-ethyl-3-hydroxy-l-hydroxyethylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [3- (morpholin-4-yl) propyl] piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (1-methyl-3-phenylpropyl) piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-y1] -N- (1-methyl-3-phenylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1-methyl-3-phenylpropyl) piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (1-methylheptyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1-methylheptyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1-methylheptyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-fluorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-fluorophenyl) methyl] piperidin-2-acetarr; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-y1] - N - [(4-methylphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (l-phenylethyl) piperidin-2-acetamide; 1- [2- (1H-imide zol-1-yl) -6-methylpyrimidin-4-yl] -N-phenylimethyl-piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N - [(3,4-dichlorophenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (2-phenylethyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- (2-phenylethyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [3- (pyrrolidon-1-yl) propyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1, 5-dimethylhexyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1,5-dimethylhexyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (1,5-dimethylhexyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl-N- [(2-fluorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(2-fluorophenyl) methyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] piperidin-2-acetarruda; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (2-chlorophenyl) ethyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-y1] -N- [(furan-2-yl) methyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- [(furan-2-yl) methyl] piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(furan-2-yl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(pyridin-2-yl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(pyridin-2-yl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-y1] -N- [(pyridin-2-yl) methyl] piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-trifluoromethylphenyl) methyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-trifluoromethylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- (2-phenylpropyl) piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- (2-phenylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (2-methoxyphenyl) ethyl] piperidine-2-acetarruda; l- [2- (lH-imidazol-1-yl) -pyrimidin-4-yl-N- [2- (2-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-y1] -N- (2-hydroxy-4-methylthiobutyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (2-hydroxy-4-methylthiobutyl) piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(2,4-dichlorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(3-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N - [(3-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (3-methoxyphenyl) ethyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) pi r imidin-4-i 1] -N- [2- (3-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; l- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- [2- (3, 4-dimethoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3,4-dimethoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (phenylbutyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -pyrimidin-4-yl] -N- (phenylbutyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1-hydroxymethylpentyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- (1-hydroxymethylpentyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] - N - [(3,5-dimethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,5-dimethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (4-ethoxyphenyl) ethyl] piperidin-2-acetarruda; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-ethoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (4-ethoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-ethoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (4-bromophenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-bromophenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (4-bromophenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-brornophenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1 H -imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N-pentylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N-pentylpipe-ridin-2-acetyl amide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N-pentylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [3- (1H-imidazol-1-yl) propyl] pipe-ridin-2-acet amide; 1- [2- (1 H-imidazol-1-yl) -6-met ilp ir imi din-4 -yl] -N- [3- (1 H-imidazol-1-yl) propyl] pipe ridin-2 -ace tarruda; 1- [2- (1H-imide zol-1-yl) -6-met ilpyr imidin-4-yl] -N - [(3-chlorophenyl) methyl] pipe ridin-2 -acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-phenyl) -methyl] -pipe-ridin-2-acetic acid; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(2,4-di chloro phenyl) methyl] piper i din-2-a-cet amide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(2,4-dichlorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [2- (1-phenyl) ethyl] piper idin-2 -aceta-free; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [1- (phenyl) ethyl] piper i din-2-acet amide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3-fluoro-phenyl) -ethyl] -pyridin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- [2- (3-ethoxy-4-methyl-phenyl) ethyl] pipe-ridin-2-acetic acid; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (3-ethoxy-4-methoxyphenyl) ethyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3-ethoxy-4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-ethoxy-4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-chlorophenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl-N- [2- (4-chlorophenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (5-hydroxypentyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N-butylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-fluorophenyl) (methyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-fluorophenyl) (methyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (2, 5-dimethoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (2, 5-dimethoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (2,5-dimethoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-met i le t ilpir imidin-4-yl] -N- [2- (4-ethoxy-3-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-ethoxy-3-methoxy phenyl) ethyl] pipe ridin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (4-ethoxy-3-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-ethoxy-3-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6 -methyl-1-yl-imidin-4-yl] -N- [2- (4-methyl-phenyl) -ethyl] piper-idin-2-acetyl-amide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-me-toxi-phenyl) -ethyl] -piper idin-2 -acetic acid; 1- [2- (1H-imidazol-1-yl) -6-met-il-pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] pipe-ridin-2 -acetic acid; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1 H-imidazol-1-yl) -6-met-ile-i-pyrimidin-4-yl-N- [3- (methylethoxy) propyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N-hexylpiperidin-2-acetamide; 1- [2- (lH-imi.dazol-1-yl) pyrimidin-4-yl] -N-hexy lp ipe ridin -2 -acet amide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl-N-hexylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (cyclohexen-1-yl) ethyl] pipe ridin-2 -acet amide; l- [2- (lH-imidazol-l-yl) -6-met ilpyr imidin-4 -i 1] -N- [2- (cyclohexen-1-yl) ethyl] pipe ridin-2 -acetic acid; l- [2- (1H-imide zol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-fluoro-5-trifluoromethylphenyl) methyl] pipe ridin-2 -acet amide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-fluoro-5-trifluoromethylphenyl) methyl] piper idin-2 -ace tarea; l- [2- (lH-imidazol-l-yl) -pyrimidin-4-yl] -N- [2- (4-methylphenyl) ethyl] pipe ridin-2-acet amide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl-N- [2- (4-methylphenyl) ethyl] piper idin-2 -acertrug; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (3-ethoxypropyl) pipe ridin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- (3-ethoxypropyl) piperidin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N-hept i lp ipe ridin -2 -acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N-heptylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilp-ir imi-din-4-yl] -N-heptyl-piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyr imidin-4-yl] -N- (3-methoxypropyl) pipe ridin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1-cyclohexylethyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- (1-cyclohexylethyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] - N - [(4-trifluoromethoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-trifluoromethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-fluorophenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (4-fluorophenyl) ethyl] piperidin-2-acetamide; 1- [2- (IH-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (3-bromo-4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-bromo-4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3-bromo-4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-bromo-4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (3-phenylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (3-phenylpropyl) piperidin-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Nm? D? N-4-? L] -N- (3-phenylpropyl) piper idm-2 -acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? Pm? D? N-4-? L-N-octylpiperidm-2 -acetarrue; l- [2- (lH-? m? dazol-l-? l) -6-met? lp? r? m? d? n-4-? l-N-octylpiperidin-2-acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? D? N-4-? L] -N- (1-h? Drox? -3-met ? lbut? l) pipe ridm- 2 -ace tarruda; 1- [2- (lH-? M? Dazol-1-? L) - 6-met? Let? Lp? R? M? Dm-4-? L] -N- [1- (4-met? Lfen (l) ethyl] p ipe n din-2 -ace tartar; l- [2- (lH-? m? dazol-l-? l) p? r? m? dm-4-? l] -N- [l- (4-methylphenyl) ethyl] p ipe ridm- 2 - ace tarruda; l- [2- (lH-? m? dazol-1-? l) -6-met? lp? r? m? d? n-4-lyl] -N- [1- (4-met? lfen? l) et? l] pipe pdm-2 -acetarrue; l- [2- (lH-? m? dazol-1-? l) -6-met? lp? pm? dm-4-? l] -N- [4, 4-diethoxybutyl) pipe r idm- 2 - acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M? Dm-4-? L] -N- [(4-tpf luoromet phenyl) til] piper din-2 -acet amide; l- [2- (lH-? m? dazol-l-? l) -p? r? m? dm-4-? l] -N- [(4-trif luoromet phenyl) useful] pipen din-2 -acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? Dm-4-? LN- [(4-tpf luoromet-phenyl) methyl] piper? Dm- 2 -acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M? D? N-4-? LN- (3-butoxypropyl) p? Pepdm-2 -acetam? da; - 3U - l- [2- (lH-? M? Dazol-1-? L) - 6-met? Lp? Pm? Dm-4-? L] -N- (3-butoxypropyl) pipe ridm- 2 - ace tarruda; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M? D? N-4-? L] -N- [2- (t? Ofen -2-? L) et? L] pipen din- 2 -ace tarruda; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? D? N-4-? L] -N- [2- (t? Ofen-2-? l) et? l] pipen din-2-a-cet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? Pm? Dm-4-? L] -N- [3- (p? Rrol? D? Nl -? l) prop? l] pipe pdm-2-acet amide; 1- [2- (lH-? M? Dazol-1-? X - 6-met? Let? Lp? R? M? Dm-4-? L] -N- [(cyclohexyl) methyl] p? Per? d-n-2-acetamido; 1- [2- (lH-? m? dazol-1-? l) p? pm? d? n-4-? l] -N- [(cyclohexyl) methyl] pipen din-2-d ce tarruda; ethyl ester of 4- [[1- (2- (lH-? m? dazol-1-? l) pinmidm-4-? l] p? per? d? n-2 -acet? l] ammo] pipen di n-1-carboxyl? co; ethyl ester of the acid 4- [[1- [2- (lH-? m? dazol-1-? l) -6-met? let? lp? r? m? dm-4-? l] p? per? d? n-2-acet? l] amino] pipen di nl-carboxylic acid ethyl ester 4- [[1- (2- (lH -? m? dazol-1-? l) -6-met? lp? r? m? d? n-4-? l] p? per? d? n-2-acet? l] am? no] p ? pepd? nl-carboxylic acid; 1- [2- (lH-? m? dazol-1-? l) -6-met? lp? pm? d? n-4-? l] -N- [(4- fluorofen? l) met? l] pipe r? d? n-2-acet amide; N - [(1, 3-benzod? oxol-5? l) met? l] -l- [3- (lH- m? dazol-1-yl) phenyl] pi-pi-di-n-2-acet amide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [3-chloro-5- (1H-imidazol-1-yl) triazin-1-yl] piperidin-2-acetamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) purin-6-yl] piperidin-2-acetamide; N - [(1,3-benzodioxol-5-l) methyl] -l- [6- (lH-imidazol-1-yl) pyrazin-2-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-propionamide; N - [(1, 3-benzodioxol-5-yl) methyl] -2- (lH-imidazol-1-yl) pyrimidin-4-propionamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- (lH-imidazol-1-yl) pyrimidin-4-propionami a; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [2- (1H-imidazol-1-yl) pyrimidin-4-oxy] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [2- (1H-imidazol-1-yl) pyrimidin-4-thio] acetamide; N- [(1, 3-benzodioxol-5? L) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-y1] piperidin-2-ethanamine; N - [(1, 3-benzodioxol-5? L) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N-methylpiper? Din-2-ethanamine; N-acetyl-N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-ethanamine; N- [(1, 3-benzodioxol-5? L) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- (methylsulfonyl) piperidin-2-ethanamine; 4- [2- [[(1,3-benz odi-oxol-5-yl) methoxy] ethyl] pipe-ridin-1-yl] -2- (1H-imidazol-1-yl) pyrimidine; 4- [2 - [[4- (methoxy) phenoxy] propyl] pyr rolidin-1-yl] -2- (1H-imidazol-1-yl) pyrimidine; 4- [2 - [[4- (methoxy) phenoxy] propyl] pyrrolidin-1-yl] -2- (lH-imidazol-1-yl) -6-met ilpyr imi dine; 4- [2 - [(1, 3-benzodioxol-yl) propyl] pyrrolidin-1-yl] -2- (lH-imidazol-1-yl) pyrimidine; 4- [2- [(1, 3-benzodioxol-5-yl) prop-2-enyl] pyr rolidin-1-yl] -2- (lH-imide zol-1-yl) pyrimidine; 4-chloro-2- (1H-imidazol-1-yl) -6- (perhydroazepin-1-yl) pyrimidine; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] piper idin-2-ethanol; 4-chloro-2- (1H-imidazol-1-yl) -6- (piperidin-1-yl) pyrimidine; 4-chloro-2- (1H-imidazol-1-yl) -6- (2-ethylpiperidin-1-yl) pyrimidine; Xfluoro-2- (1H-imidazol-1-yl) -6- [[(3, A-dimethoxyphenyl) ethyl] amino] pyrimidine; 4 - f l u o r o - 2 - (l H - i mi d a z or l - l - i l) - 6 - [[(phenyl) ethyl] amino] pyrimidine; N- [(1,4-benzodioxan-6-yl) methyl] -l- [2- (lH-triazol-1-yl) pyrimidin-4-yl] -4- [(di-methylkexy) carbonyl] piperazine- 2-acetamide; N- [(1, 3-benzod? Oxol-5? L) met? L] -l- [6- (morphol? N-4-? L) -2- (lH-? M? Dazol-1- ? l) p? pm? dm-4-? l] pipe ndm- 2 -ace tarruda; N- [(1,3-benzod? Oxol-5? L) met? L] -4- [2- (lH-? M? Dazol-1-yl) -6-methox? P? R? M? dm-4-? l] -p? per? dm-2-acetarruda; N- [(1, 3-benzod? Oxol-5? L) met? L] -4- [6- [bis (ethoxy? Carbon? L) met? L] -2- (lH-? M? -1-? L) p? Pm? D? N-4-? L] -1- [(methoxy) carbonyl] pipera zm-2-acetamide; N- [(1,3-benzod? Oxol-5? L) met? L] -4- [6- (apunocarbonyl) -2- (lH-? M? Dazol-1-? L) p? R? m? d? n-4-? l] -1- [(methoxy) carbonyl] p? peraz? n-2-acetam? da; N - [(1, 3-benzod? Oxol-5? L) met? L] -3- [2- (lH-? M? Dazol-1-yl) p? R? M? D? N-4 -? l] -4-methox? benzam? da; 4-chloro- 2 - (1H-? M? Da zol-1-yl) -6 - [(2-methoxyphenyl) arrimo] pyrimy; N- [(1, 3-benzod? Oxol-5? L) met? L] -1- [2- (lH-? M? Dazol-1-yl) p? R? M? Dm-4-? l] mdol-6-carboxamide; N- [(1,3-benzod? Oxol-5? L) et? L] -l- [2- (lH-imidazol-l-yl) p? R? M? Dm-4-? L] p ? rrol-2-carboxam? da; N - [(3,4-d? Methox? Phen? L) et? L] -2- [2- (lH-? M? Dazol-l-l) p? Pm? Dm-4-? L] - 1,2,3, 4-tetrahydro? Soqu? Nolm-3-carboxam? Da; N- [(1,3-benzod? Oxol-5? L) et? L] -l- [2- (lH-? M? Dazol-1-yl) p? R? M? Dm-4-? l] p? rrol? d? n-2-prop? onam? da; N- [(1,3-benzod? Ox X-5-? L) ethyl] -1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? dm-4-? l] p? rrol? dm-2-prop? onam? da; N- [(3,4-dimethoxy phenyl) ethyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidine-3-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-3-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] - [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidin-3-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidin-3-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidin-3-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -acetidine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxan-6-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl-N - [(1,4-benzodioxan-6-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N - [(4-methoxyphenyl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(3,4-dimethoxyphenyl) ethyl] morpholin-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(4-methoxyphenyl) methyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl-N- [(4-methoxyphenyl) methyl] morpholin-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] morpholin-2-acetamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] morpholin-2-acetamide; N- [(1, 3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] morpholine-3-carboxamide; N- [(1, 3-benzodioxol-5-yl) methyl] -4- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] morpholine-3-carboxamide; N - [(1, 3-benzodioxol-5-yl) ethyl] -4- [6-ethyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] morpholine-3-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] morpholine-3-carboxamide; N - [(4-methoxy phenyl) met il-4- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N - [(4-chlorophenyl) methyl] -4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N- [(3,4-dichlorophenyl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N - [(4-methylphenyl) methi 1-4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N- [(3,4-Dimethylphenyl) methyl] -4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N- [(1,3-benzodioxol-5? L) methyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] acetamide; N- [(1,4-benzodioxan-6-yl) methyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] acetamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-y1] perhydroazepin-2-carboxamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1,4-benzodioxan-6-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1,4-benzodioxan-6-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) • 6-ethylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1, 3-benzodioxol-5-yl) ethyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1,4-benzodioxan-6-yl) ethyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1,4-benzodioxan-6-yl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-ethyl-pyrimidin-4-yl] -perhydroazepin-2-carboxamide; N - [(3,4-dimethoxyphenyl) methyl] -1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepine-2-carboxamide; N- [(3, -dimethoxy phenyl) ethyl] -1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (1H-imidazol-1-yl) -6-ethylpyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(1,4-benzodioxan-6-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(1,4-benzodioxan-6-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(3,4-dimethoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(3,4-dimethoxyphenyl) methyl] -l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(3,4-dimethoxyphenyl) ethyl-1- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(-methoxy phenyl) methyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl-l- [6-chloro-2- (pyridin-3-yl) pyrimidin-4-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-ylperhydroazepin-2-acetamide; N- [(4-trifluoromethoxyphenyl) methyl] -1- [(2- (1H-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetamide; and N- [(4-trifluoromethoxyphenyl) methyl] - 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; Although the present invention has been described with reference to the specific embodiments thereof, it should be understood by those familiar with the art that various changes can be made and equivalents can be substituted without departing from the true spirit and scope of the invention.

In addition, many modifications can be made to adapt a particular situation, material, composition of matter, process, step or process steps to the object, spirit and scope of the present invention. All such modifications are considered within the scope of the claims appended hereto.

Claims (2)

1. CLAIMS 1. Compound of formula (I), formula (II) and formula (neither: - A 'III' wherein: A is -R1, -OR1, -CfO fR ^ R2, -P (O) [N (R1) R2] 2, -n (R1) C (0) R2, -N (Rld) C (0) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, -StO? R1. -SO NHCÍOJR1, -NHS02R22, -SO, N (R1) H, -C (0) NHSO, R22, and -CH = NOR1; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, O or C (RJ) H; each W is N or CH; Q is chosen from the group consisting of a direct link, -C (O) -, -O-, -C (= N-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -N (RX) R2X -NtR ^ JCtOJNtR ^ R16, -SFOXR1 (when t is zero) or -NHSO, R22, n, qyr can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R1) C (0) R2, -N (Rld) C (0) OR2, -N (R2) R21, -N (R16) C (0) N (R1) R16, -SÍOXR1 (when t is zero) or -NHSO, R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted XC ^ alkyl, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C2-C6 alkenyl] -R9, - [alkynyl] of C2-C6] -R9, - [C, -C6 alkyl] -R10 (optionally substituted by hydroxy), - [Ci-C-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [XC alkyl] -N (R1) R2, - [C_-Cß alkyl] -N (R2) R2, - [X-CgUR6 alkyl, - [C2-C8 alkyl] -R10, - [X-CgJ-R11 alkyl, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -UOWR ^ R2, -C (= NH) -N (R:) R2 O R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R "can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, aralkyl optionally substituted, aryl optionally substituted, -OR 16 S (0) t-Rlb, -N (Rlb) R21, -NYR ^ JCÍOJNtR ^ R16, -N (R16) C (O) OR16, -N (R16) C (0 ) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C8 alkyl] -C (H) [C (0) 0R16], and - [Co-CeUCIOWR alkyl R16; R6] is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C_-C8 alkyl] -R8, - [C2-C8 alkyl] -R10, - [Ci-Cg alkyl] -R11, acyl, -C (0) R8, -C (O) - [XC.J-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl , monoalkylaminocarbonyl, dialkylaminocarbon ilo, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, - C (0) -R23-N (R1) C (0) -R23-N (R1) R2, -C (0) -N (R1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, NO, or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -SO, R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof.
2. 2. Compound of formula (I), as described in clause 1, which has the formula (la), formula (Ib) or formula (le): 3. Compound as described in clause 2, wherein: A is -OR1, -ClOlNfR1) ^, -N (R16) C (0) N (R1) R16, -NR ^ tOJR2 or -NRI R2; V is N (R4); V is N (R4); and W is CH. 4. Composite as described in clause 3, where: A is -CFOINTER ^ R2; q, r and n are zero; R1 is hydrogen; and R2 is lower alkyl or - [C_-C8] -R9; R 4 is hydrogen or lower alkyl; and R5 is hydrogen, halo, alkyl or alkoxy. 5. Compound as described in clause 4, wherein R9 is phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, chlorophenyl, carboxyphenyl, dimethoxyphenyl, 2-thienyl or morpholinyl. 6. Compound as described in clause 2, where: A is -UOJNÍR ^ R2; m is zero; Q is a direct link to R3; and R3 is hydrogen. 7. Compound as described in clause 6, for example N - [(1,3-benzodioxol-5-yl) ethyl] -4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-i1 ] (methyl) amino] acetamide. 8. Compound of formula (II) as described in clause 1, having the formula (lia), formula (Ilb), or formula (lie): IIb); or 9. Compound as described in clause 8, wherein the N-heterocyclyl is selected from the group consisting of piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, acetidinyl, indolyl, pyrrolyl, imidazolyl, tetraisoquinolyl and perhydroazepinyl. 10. Compound as described in clause 9, wherein the N-heterocyclyl is piperazinyl substituted by R5, for example, the compound of formula (lid), formula (lie), or formula (Ilf): 11. Compound as described in clause 10, wherein: A is -OR1, -CtOlNfR1) ^, -NÍR ^ UOjNÍR ^ R16, -NRX (0) R2 or -NfR ^ R21; W is CH; and R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl of X-CgJ-R8, - [C2-C8 alkyl] -R10, - [C_-C3 alkyl] -Rn. acyl ,, -C (0) R8, -C (0) - [Ci-CgJ-R8 alkyl, alkoxycarbonyl, optionally substituted alkoxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, aryisulfonyl optionally substituted, aminocarbonyl, monoalkylcarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, N-heterocyclyl optionally substituted, -C (= NH) -N (CN) R1, -C (O) -R23-N (R1) R2, -C (O) -R23-N (R1) C (0) -R23-N (R1) R2 and -C (0) -N (R1) -R23-C (0) OR1. 12. Compound as described in clause 11, wherein A is -C (0) N (R0R2; R1 is hydrogen; R2 is lower alkyl, - [C_-C8 alkyl] -R9, or UX-C8] -R10 Rd is hydrogen, acetyl, t-butoxycarbonyl, 4-methoxyphenylaminocarbonyl, 4-methoxyphenylmethyl, methoxycarbonyl, methyl or benzyl, R5 is hydrogen, halo, alkyl or alkoxy, and n is O or 1. 13. Compound as described in clause 12, wherein: R2 is -CH2-R9 or - [C_-CB] -R10; R9 is aryl or substituted aryl; and R10 is methylthio. 14. Compound as described in clause 13, wherein: R2 is -CH, -R9; R6 is hydrogen, acetyl or t-butoxycarbonyl; and R9 is phenyl, tolyl, anisyl, 1,4-benzodioxan-6-yl, 1,3-benzodioxol-5-yl, methylothiophenyl, chlorophenyl, carboxyphenyl, dimethoxyphenyl or 2-thienyl. 15. Compound as described in clause 14, wherein R5 is chloro, R6 is hydrogen and R9 is p-tolyl. 17. Compound as described in clause 14, wherein R 5 is chloro, R 6 is hydrogen and R 9 is 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl. 18. Compound as described in clause 14, wherein R5 is chloro, R6 is t-butoxycarbonyl and R9 is 1,4-benzodioxan-6-yl or 1,3-benzodioxol-5-yl. 19. Compound as described in clause 10, which is selected from the group consisting of: N- [(1,3-benzodioxol-5-yl) ethyl] -4- [2- (lH-imidazol-1-yl) - 6-methylpyrimidin-4-yl] -1- (2-methyl-l-oxopropyl) piperazin-2-acetamide; N- [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -4- (methoxycarbonyl) piperazin-2- acetamide; N- [(1,4-benzodioxan-6-yl) methyl] -l- [2- (lH-triazol-1-yl) pyrimidin-4-yl] -4- (dimethylethoxy) piperazine-2-acetamide; N- [(1,3-benzodioxol-6-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methoxypyrimidin-4-yl] -1- (methoxycarbonyl) piperazin-2 acetamide; l- (acetyl) -N - [(1,3-benzodioxol-5-yl) methyl] -4- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (methylsul fonyl) piperazin-2- acetamide; and 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(pyridin-3-yl) methyl] -4- (tetrahydro-3-furanoyl) piperazine-2-carboxamide. 20. Compound as described in clause 9, wherein the N-heterocyclyl is optionally substituted by piperidinyl, for example, the compound of formula (Hg), formula (Hh), or formula (Ili): 21. Compound as described in clause 20, where: A is -OR1, -C (0) N (RjR-, -N (R16) C (O) N (R1) R16, -NR1C (0) R2 or -NfR ^ R21; and W is CH. 22. Compound as described in clause 21, where A is -C OjNÍR ^ R2; R1 is hydrogen; R 2 is lower alkyl or - [C 1 C-R 9 alkyl; R5 is hydrogen, halo, alkyl or alkoxy; and n is zero or 1. 23. Compound as described in clause 22, wherein R 2 is lower alkyl or -CH-R 9 and R 9 is 4-methoxyphenyl, 1,4-benzodioxan-6-yl, 1,3-benzodiozol-5-yl or 3, 4 -methoxyphenyl. 24. Compound as described in clause 20, which is selected from the group consisting of: N- [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidine -4-i1] piperidin-2-ethanamine; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (morpholin-4-yl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (methylhexyl) piperidin-2-acetamide; N- [(4-chlorophenyl) methyl] -1- [2,6-bis (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) pi rimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperidin-2-acetamide; and N- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (1 H -imidazol-1-yl) -6-methoxypyrimidin-4-yl] piperidin-2-acetamide. 25. Compound as described in clause 9, wherein the N-heterocyclyl is optionally substituted by pyrrolidinyl, for example the compound of the formula (IIj), the formula (Hk), or the formula (Hm): 10 25 26. Compound as described in clause 25, where: A is -OR1, -C (0) N (R1) R :, -N (R16) C (0) N (R1) R15, -NR ^ tOJR2 or -NÍR ^ R21; and W is CH. 27. Composite as described in clause 26, where: A is -CFONfR1) ^; R1 is hydrogen; R2 is lower alkyl or - [C_-C8 alkyl] -R9; R5 is hydrogen, halo, alkyl or alkoxy; and n is zero or 1. 28. Compound as described in clause 27, in which it has the R-configuration at C-2 of the pyrrolidinyl ring. 29. Compound as described in clause 25, which is selected from the group consisting of: N- [(1,3-benzodioxol-5-? L) ethyl] -4- [2- (lH-imidazol-1-yl) - 6-methylpyrimidin-4-yl] -pyrrole idin-2 -carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] -pyrrolidin-2-carboxamide; N - [(3,4-dimethoxy phenyl) methyl] -1- [2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -pyrrolidin-2-acetamide; N- [(4-methoxy phenyl) ethyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -pyrrolidine-2-carboxamide; and N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] -pyrrolidin-2-acetamide. 30. Compound as described in clause 9, which is selected from the group consisting of: 4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5 -yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] thiomorpholin-2-acetamide; N- [(1,3-dioxolan-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -perhydroazepin-2-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -acetidine-2-carboxamide; and 4- [2- (lH-imidazol-1-yl) pi rimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] morpholine-2-carboxamide. 31. Compound of formula (III) as described in clause 1, in which it has the formula (Illa), formula (IHb), or formula (lile): TO 33. Compound as described in clause 1, of formula (I), formula (II), or formula (III), wherein each X, Y or Z is C (R19) and each U is C (R6), where each R19 and R5 are as described above in clause 1. 34. Compound as described in clause 1, of formula (I), formula (II), or formula (III), wherein each X, Y or Z is N and each U is C (R5), where each R5 is as described above in clause 1. 35. Compound as described in clause 1, of formula (I), formula (II), or formula (III), wherein each X is N, each Z or Y is C (R19), and each U is N, where each R19 is as described above in clause 1. 36. Compound as described in clause 1, of formula (I), formula (II), or formula (III), in which in each formula, one of X, Y or Z is N and the others are C (R19) , and U is C (R5), where each R19 and R5 are as described above in clause 1. 37. Compound of formula (IV): wherein: AA is an amino acid; X, Y and Z are independently? or C (R19); U is it? or C (R5), with the proviso that U is? only when X is? and Z and Y are CR19; is ? or CH; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl of X-C ,. optionally substituted, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, - [C, -C8 alkenyl] -R9, - [C, -C8 alkynyl] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [X-CgJ-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is an optionally substituted? -heterocyclyl; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -N (Rld) C ( 0) N (R1) R16, -N (R16) C (0) OR: é, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (O) OR16, - [alkyl] of C0-CS] -C (H) [C (0) OR16] 2 and - [C0-C8 alkyl] -C (O) N (R ^ R ^ - each R9 is independently selected from the group consisting of haloalkyl , cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy), each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R19 is hydrogen, alkyl (optionally substituted by hydroxy), cyclopropyl, halo or haloalkyl; each R21 is hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with Ri6 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and t is zero, 1 or 2; as a single isomer or mixture thereof, or a pharmaceutically acceptable salt thereof. 38. Compound as described in clause 37, of formula (IVa), formula (IVb), or formula (IVc): 39. Compound as described in clause 38, wherein the amino acid is an a-amino acid of the L configuration on the carbon with respect to the acid. 40. Compound as described in clause 38, wherein the amino acid is an a-amino acid of the D configuration on the carbon with respect to the acid. 41. Compound as described in clause 38, wherein: R1 is hydrogen; R 2 is lower alkyl or - [C 1 C-R 9 alkyl; and R5 is hydrogen, halo, alkyl or alkoxy. 42. Compound as described in clause 41, wherein R9 is phenyl, tolyl, anisyl, 1,4-benzodiozan-6-yl, 1,3-benzodioxol-5-yl, chlorophenyl, carboxyphenyl, 2-thienyl, dimethoxyphenyl or morpholinyl. 43. Compound of the formula (Va), formula (Vb), or formula (Ve): wherein B is a 5 or 6 membered carbocyclyl or heterocyclyl, optionally substituted; and wherein: A is -R1, -OR1, -C (0) N (R1) R2, -P (O) [N (R1) R2] ,, -N (Rx) C (0) R2, -N (R16) C (0) OR2, -N (R1) R: 1 -N (R16) C (O) N (R1) R16, -SfOXR1, -SO .NHCfOJR1, -NHSO, R22, -S02N (R1) H, -C (O) NHSO, R22, and -CH = NOR1; each of X, Y and Z are independently N or C (R19); V is N (R4), S, O or C (R) H; each W is N or CH; Q is selected from the group consisting of a direct bond, -C (0) -, -O-, -CXN-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (O) R2, -N (R15) C (O) OR2, -N (RX) R21, -NÍR ^ CÍOÍNÍR R15, -SdXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R1) C (0) R2, -N (Rld) C (O) OR2, -NYR ^ R21, -N (R16) C (O) N ( R1) R16, -SÍOÍt-R1 (when t is zero) or -NHSO: R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, [C-C8 alkenyl] -R9, - [ C2-C8 alkynyl] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [X-Cg] -Ru (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C_-C8 alkyl] -C (0) N (R1) R2, - [C_-C8 alkyl] -N ( RX) R2, - [C_-C8 alkyl] -R8. - [C2-C8 alkyl] -R10, - [C_-C8 alkyl] -Ru, and heterocyclyl (optionally substituted by 1 or more substituents which are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C (0) N (Rx) R2, -C (= NH) -N (RX) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl of X-CgJ-R8, - [C, -C8 alkyl] -R10, - [alkyl of X-Cg-R11, acyl, -C (0) R8, -C (O) - [C, -C8] -R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl , aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N ( R1) R2, -C (0) -R23-N (R1) C (0) -R23-N (R1) R2, -C (0) -N (R2) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R1S is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R :: or -SO, R22; or R21 taken together with R- and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. 44. Composite as described in clause 43, in which each X and each Y is N; each is CH; and B an optionally substituted fused heterocyclyl. 45. Compound as described in clause 44, of the formula (Vba): wherein A is -OR1, -C (O) N (R1) R2, -N (R16) C (O) N (R1) R16, NRX (0) R2 or -N (R R21; is N-heterocyclyl which is selected from the group consisting of piperidinyl, piperazinyl, pyrrolidinyl or morpholinyl. 46. Compound as described in clause 45, for example N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -purin-6-yl] piperidin-2-acetamide. 47. Compound of formula (Via), formula (VIb) or formula (VIc): wherein B is a 5 or 6 membered carbocyclyl or heterocyclyl, optionally substituted; and wherein: A is -R1, -OR1, -CfOJNtR ^ R2, -P (0) [N (R1) R2] 2, -NtR'lCIOJR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, S -SYOtR1, -S02NHC (0) R1, -NHSO, R22, -S0, N (R1) H, -C (0) NHSO, R22, and -CH = N0R1; each of X, and Z are independently N or C (R19); V is N (R4), S, 0 or C (R4) H; each is N or CH; 0 Q is chosen from the group consisting of a direct link, -C (0) -, -0-, -CUN-R1) -, -S (0) t. and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; 5 r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -0R1, -N (R1) C (0) R2, -N (R16) C (0) 0R2, -NYR ^ R21, -NÍR ^ UO? NÍR ^ R16, -StOXR1 (when t is zero) or -NHSO, R22, n, q and y can not all be zero; and when Q is a heteroatom and A 0 is -OR1, -NtR ^ UOJR2, -N (R16) C (0) 0R :, -NfR ^ R21, -N (R16) C (0) N (R1) R16, -SdXR1 (when t is zero) or -NHSO: R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, - [C0-C5 alkyl] -R9, [C2-C6 alkenyl] -R9, - [alkynyl] of C, -C6] -R9, - [C2-C6 alkyl] -R10 (optionally substituted by hydroxy), - [C_-C,] -Rn (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C: -C8 alkyl] -N (R1) R2, - [C_-C8 alkyl] -N (RX) R2 , - [C_-C8 alkyl] -Re. - [C2-C8 alkyl] -R10, - [alkyl of X-C-R11, and heterocyclyl (optionally substituted by 1 or more substituents which are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -UOJNÍR ^ R2, -C (= NH) -NÍR ^ R2 O R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R 6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C 1 -C 8 alkyl, - [C 2 -C 8 alkyl] -R 10, - [C 1 -C 6 alkyl, acyl, -C ( 0) R8, -C (0) - [C1-CJ-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (O) -R23-N (R1) R2 , -C (0) -R23-N (R1) C (0) -R23-N (R1) R2, -C (O) -N (R1) -R23-C (O) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R 12, R 13, R 14, R 15 R: "and R 20 are independently hydrogen or alkylene R 16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, NO, or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R :: or -SO, R22; or R21 taken together with R: and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. 48. Compound of formula (Vlla), formula (Vllb) or formula (VIIc): (Vllb); or wherein: A is -R1, -OR-, -UOJNÍR ^ R2, -P (O) [N (R1) R2] 2, -N (RL) C (0) R2, -N (R16) C (0) OR2, -NfR ^ R21, -N (R16) C (O) N (R1) R16, -SYOtR1, -S02NHC (0) R1, -NHS02R22, -SO, N (R1) H, -C (O) NHSO, R22, and -CH = NOR1; each of X, Y and Z are independently N or C (R19); each U is N or C (R7, with the proviso that U is N only when X is N and Z and Y are CR19, V is N (R4), S, O or C (R4) H, each is N o CH; Q is chosen from the group consisting of a direct link, -C (O) -, -O-, -CXN-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -NfR ^ R21, -NÍR ^ CÍOJ ÍR ^ R16, -StO-R1 (when t is zero ) or -NHSO, R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R2) C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -S (0) tR1 (when t is zero) or -NHSO, R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C-C8 alkenyl] -R9, - [alkynyl] of C2-C8] -R9, - [C2-Ce alkyl] -R10 (optionally substituted by hydroxy), - [C-C8] -Rn (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C_-C8 alkyl] -C (O) N (R1) R2, - [C_-C8 alkyl] -N ( RX) R2, - [C_-C8 alkyl] -R ?, - [C2-C8 alkyl] -R10, - [Ci-CgJ-R11 alkyl, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -CfOJNtR1) ^, -C (= NH) -N (R :) R2 or OR R1:? P R2 R4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -ri. { R16) C (0) i (R1) R16, -N (R16) C (0) OR16, -N (R16) C (0) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C8 alkyl] -C (H) [C (0) OR16] 2 and - [alkyl of R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C_-C8 alkyl] -R8, - [C2-C8 alkyl] -R10, - [C_-C3 alkyl] -Ru. acyl, -C (0) R8, -C (0) - [XC.J-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, arylfulsonyl optionally substituted, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (O) -R23- N (R1) R2, -C (O) -R23-N (R1) C (0) -R23-N (R1) R :, -C (O) -N (R1) -R23-C (O) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents which are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkylene R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R2: or -SO, R22; or R21 taken together with R1 and the nitrogen to which they are attached is optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. 49. Compound as described in clause 48, for example N - [(1, 3-benzodioxol-5-yl) methyl] -1- [6-chloro-2- (pyridin-3-yl) pyrimidin-4-yl] piperidin-2-acetamide. 50. Compound of formula (VIII): HIV) in which two of X, Y and Z are nitrogen and the third is CH. 51. Compound as described in clause 50, which is 4,6-dichloro-2- (lH-imidazol-1-yl) pyrimidine. 52. Compound as described in clause 50, which is 2,4-dichloro-6- (lH-imidazol-1-yl) pyrimidine. 53. Compound of formula (IXa), formula (IXb) or formula (IXc): in that it is a solid substrate; L is bond residue; each of X, Y and Z are independently N or C (R10); each U is N or C (R7, with the proviso that U is N only when X is N and Z and Y are CR19, V is N (R4), S, O or C (R) H, each is N o CH; Q is selected from the group consisting of a direct bond, -C (O) -. -O-, -C (= N-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (O) R2, -N (R16) C (O) OR2, -N (RX) R21, -NIR ^ ICIOINIR'IR15, -SdXR1 (when t is zero) or -NHS02R22, n, q and r can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R:) C (0) R2, -N (R16) C (O) OR2, -N (R:) R21, -N (R16) C ( O) N (R1) R16, -SÍOXR1 (when t is zero) or -NHSO-R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; each R 2 is independently selected from the group consisting of hydrogen, C 1 -C alkyl, or optionally substituted, optionally substituted cycloalkyl, C0-C6] -R9, [C2-C8 alkenyl] -R9, - [C2-C8 alkynyl] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [X-C-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [X-Cg alkyl] -N (R1) R2, - [X-Cg alkyl] - N (RX) R2, - [X-Cg alkyl -R0, - [C2-C8 alkyl] -R10, - [X-CeJ-R11 alkyl, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo , alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -CÍOJN R ^ R2, -C (= NH) -N (R2) R: or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -N (R16) C ( 0) N (Ri) R16, -N (R16) C, 0) OR-6, -N (R16) C (0) R16, - [C0-C8 alkyl] -C (O) OR16, - [alkyl of C0-C8] -C (H) [C (0) OR16] 2 and - [alkyl of R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C 1 -C 8 alkyl, - [alkyl] of C2-C8] -R10, - [alkyl of C.-Cl-R11, acyl, -C (0) R8, -C (0) - [alkyl of X-CgJ-R8, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonyl nocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0) -R23-N (R1) C (0 ) -R23-N (R1) R, -C (0) -N (R1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxXalkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R-7 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, NO, or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R :: or -SO, R22; or R21 taken together with R6 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. 54. Compound as described in clause 53, in which L is a photolitically separable link of formula (X): in which the valency not satisfied to the right of the formula represents the point of attachment to the solid substrate, and the valence not satisfied to the left of the formula represents the point of binding to the ligand. 55. Compound as described in clause 1, which is selected from the group consisting of: l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] piperazin -2-acetarruda; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methylphenyl) methyl] piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pi rimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3-hydroxy-N - [(1,3-benzodioxol-5-yl) methyl] propanamide; 2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) methyl] pentanediamine: 2- [[2- (lH -imidazol-1-yl) pyrimidin-4-yl] amino] -5- [[amino (nitroimino) methyl] amino] -N - [(1,3-benzodioxol-5-yl) methyl] pentanamide; 2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3- (thiophen-2-yl) -N- [3- (morpholin-4-yl) propyl] propanamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-c-loro-phenyl) -methyl] -piperazin-2 -acetic acid; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] piperazin-2-acetamide; N - [(4-chloro-phenyl) methyl] -1- [2,6-bis (1 H -imidazol-1-yl) pyrimidin-4-y1] pipe ridin-2 -acet amide; N- [(1, 3-Benzodioxoi-5-yl) methyl] -4- [2- (1H-imidazol-1-yl) -6-methoxypyrimidin-4-yl] -1- (methoxycarbonyl) piperazine-2 - acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -4- (methoxycarbonyl) pipera zin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] piper idine -2 -acet amide; l- [6-Chloro-2- (lH-imidazol-1-yl)? irimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperidine-2-acetarruda; 1- [6-chloro-2- (lH-? Midazol-1-yl) pyrimidin-4-yl] -N- [phenylimethyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-inidazol-1-yl) pyrimidin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [3-phenylpropyl] piperazine-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2-phenylethyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(thiophene-2-yl) methyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-? midazol-1-yl) pyrimidin-4-yl] -N- (methyl) piperazin-2-acetamide; 2- [[6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-y1] amino] -3- (methylthio) -N- [(1,3-benzodioxol-5-yl) methyl] butanamide; 2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -4- (methylthio) -N- [(4-methoxyphenyl) methyl] butanamide; 2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4- (methylthio) -N- [2- (3, 4-dimethoxyphenyl) ethyl] butanamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4- (methylthio) -N- (methyl) butanamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3 - [(1,1-dimethylethyl) thio] -N- [3- (methylthio) propyl] ] propanamide; 2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] amino] -3 - [(1,1-dimethylethyl) thio] -N- [3- (phenyl) propyl] ] propanamide; a- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, 4-dimethoxyphenyl) ethyl] -2-thiophenpropanamide; a - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- (butyl) -2-thiophenpropanamide; a- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] amino] -N - [(1,3-benzodioxol-5-yl) methyl] -2-thiophenpropanamide; 2 - [[6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] amino] -3 - [(1,1-di-methylethyl) thio] - N - [2 - (3 , 4-dimethoxyphenyl) ethyl] propanamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, -dimethoxyphenyl) ethyl] acetamide; 2 - [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [2- (3, 4-dimethoxyphenyl) ethyl] propanamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-y1] amino] -N- [2- (3, 4-dimethoxyphenyl) ethyl] pentanediamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [(4-methoxyphenyl) methyl] pentanediamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] pentanediamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -5- [[amino (nitroimino) methyl] -amino] pentanamide; 2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -N - [(4-methoxyphenyl) methyl] - 5 - [[imino (amino) methyl] amino] ] peitanamide; 1- [6-chloro-2- (lH-inidazol-1-yl) pyrimidin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 2- [[6- chloro- 2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -N- [(4-methoxyphenyl) methyl] -5 - [[imino (nitroamino) methyl] -amino] pentanamide; N- [(1,3-benzodioxol-5-yl) methyl) -2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] -5- [ [amino (imino) methyl] -amino] pentanamide; l- [6-Chloro-2- (lH-? midazol-l-yl) pyrimidin-4-yl] -4-hydroxy-N- [4- (hydroxycarbonyl) phenyl]] tyl] pyrrole idin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-y1] amino] -3-hydroxypropanamide; 6-amino [[6-chloro-2- (lH-imidazol-1-yl) pyrimin-4-yl] amino] -N- [2- (3, 4-dimethoxy phenyl) ethyl] hexanamide; a- [[6-chloro- 2- (lH-i) zol-l-yl) pyrimidin-4-yl] amino] -N- [3- (methylsul-fonyl) -propyl] -benzene-propanamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] (methyl) amino] acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -6- [[6-chloro-2- (1H-imidazol-1-yl) py [mu] im] din-4-yl] amino] hexanamide; 5-amino-N- [(1, 3-ber z odi oxol-5-yl) methyl] -2- [[6-chloro-2- (1 H-imidazol-1-yl) pyrimidin-yl] amino ] pentanamide; 5-amino-N-butyl-2- [[6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-y1] amino] pentanamide; 4- [3-hydroxy-3-oxopropyl) amino] -3- [[6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] amino] -4-oxobutanoic acid; 2- [[6-chloro-2- (IH-imidazol-1-yl) pyrimidin-4-yl] (methyl) amino] -N- [(pyridin-4-yl) methyl] acetamide; 1- [6-chloro-2- (1H-? Midazol-1-yl) pyrimidin-4-yl] -N-methylpiperidine-2-carboxamide; N- [2- (3, 4-dimethoxy phenyl) ethyl] -α- [[6- (lH-imidazol-1-yl) pyrimidin-4-y1] amino] -2-t? Ofenpropanamide; N- [(1, 3-benzodioxol-5-yl) methyl] -2- [[6- (IH-imidazol-1-yl) pyrimidin-4-y1] amino] -4-methylpentanamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[6-2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] pentanediamide; N- [2 (3,4-dimethoxy phenyl) ethyl] -2 - [[6- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -4-m-thylpentanamide; N- [(1,3-benzodioxol-5-yl) methyl] -2 - [[6- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] -3-h? Droxypropanamide; N- [(1,3-benzodioxol-5-yl) methyl] -α- [[6- (1H-imidazol-1-yl) pyrimidin-4-yl] amino] benzenepropanamide; 5- [[amino (imino) methyl] amino] -6- (lH-imidazol-1-yl) pyrimidin-4-y1] -N- (phenylmethyl) pentanamide; N- [(1,3-benzodioxol-5-yl) methyl] -1,4-bis [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] piperazin-2-acetamide; N- [(1,3-benzodioxU-5-yl) methyl] -1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -4- [[phenyl] amino] carbonyl] -piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4- [(methoxy) carbonyl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; l- (acetyl) -N - [(1,3-benzodioxol-5-yl) methyl] -4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidi-4-yl] piperazin-2 -acetamide; 4- [2- (lH-imidazol-i -yl) -6-methylpyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -1-methylpiperazin-2-acetamide; 4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -1-methylpiperazin-2-acetamide; N- [(3-chloro-4-methoxymethyl) methyl] -4- [2- (lH-imidazyl-1-yl) -8-methylpyrimidin-4-yl] -l-methylpiperazin-2-acetamide; 4- [6-chloro-2- (lH-iridazol-1-yl) pyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) methyl] -1-methylpiperazin-2-acetamide; 4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4,5-trimethoxyphenyl) methyl] -1-methylpiperazin-2-acetamide; N- [2- (1,4-benzodium > an-6-yl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -1-methylpiperazine-2-acetamide; l-butyl-4- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-y1] - N - [(furan-2-yl) methylpiperazi- n-2-carboxamide; N- [(4-Benzodioxan-6-yl) methyl] -l-butyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] pipet. : ^ n-2-acetamide; N- [2- (1, 4-benzodi-6-yl) ethyl] -l-butyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] pipera zin- 2 - a ce tarruda; N- [(2,3-dimethoxyphenyl) methyl] -l-butyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazin-2-acetamide; 4- [6-chloro-2- (lH-ip ida zol-l-yl) pyr imidin-4 -i 1] -N- [(4-chlorophenyl) methyl] -1- [(4-methoxymethyl) methyl] ] piper a zin-2 -acet ami da; 4- [6-methyl-2- (lH-im? Dazyl-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -1- r (4 - me toxi phenyl) methyl] pipe razin-2-carboxamide; 4- [2- (1H-imidazcI-1-yl) pyrimidin-4-yl] -N- [(4-chloro-phenyl) -methyl] -1- [(4-methoxy-1-phenyl) -ethyl] -piperazine-2 -acetamide; 4- [6- (lH-imidazo-l-yl) pyr imidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -1- [(4-methoxy-enyl) methyl] ] piperazine-2-carboxamide; 4- [6-methyl-2- (lH-ip? Dazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -1- [(4-methoxyphenyl) methyl] piperazine- 2-acetamide; 4- [6-chloro-2- (lH-in ida zol-l-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -1- [(4-methoxy phenyl) methyl] piperazin-2-acetamide; 4- [6-met il-2- (lH-in-idazol-1-yl) -pyridin-4-yl] -N- [(4-methoxy phenyl) ethyl] -1- [(4-methoxy); ifenyl) methyl] piperazin-2-acet amide; 4- [6-methyl-2- (lH-im-dazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -1- [(4-methoxyphenyl) methyl] piperazine -2-acetamide; 4- [6-chloro-2- (1H-: midazol-1-yl) pyrimin-1-yl) -N- [(indan-5-yl) methyl] -1- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; N- [(1, 3-benzod L xol-5-yl) methyl] -l- [(2,3-dichlorophenyl) methyl] -4- [2- (lH-imidazol-l-yl) pyrimidin-4 -yl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(3,4-dichloroyenyl) methyl] -4- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] piperazine-2-carboxamide; N- [(1, 3-benzod? Oxol-5-yl) methyl] -l- [(3,4-dichlorophenyl) methyl] -4- [2- (lH-imidazol-1-yl) pyrimidine-4- il] piperazin-2-carboxamide; 4- [6-met il-2- (lH-ipida zol -1-yl) pir imidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] -1 - [ (3,4-dichlorophenyl) methyl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-1-yl) pyrimidine- 4-yl] piperazin-2-acetamide; N- [(1,3-benz odi-oxol-5-yl) methyl] -1- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(1,3-benzodioxol-5-y1) me ti 1] -4- [6-chloro-2- (AH-imidazole -l-yl) pyrimidin-4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(1,3-benzodioxol-5-yl) methyl] -4- [6- (lH-imidazol-l-yl) pi r imidin-4-yl] piperazine-2-carboxamide; N- [2- (1, 3-benzodiox-5-yl) ethyl] -l- [(1,3-benzodioxol-5-yl) met il] -4- [2- (lH-imidazol-1-yl) ) -6-methylpyrimidin-4-yl] pipera zin-2 -acet amide; N- [2- (1, 3-benzodiox X-6-yl) ethyl] -l- [(1,3-benzodioxol-5-yl) me ti 1] -4- [2- (lH-imidazol-l -yl) -6-methylpyrimidin-4-yl] piperazin-2-acet amide; N- [(4-methoxyphenU) methyl] -l- [(1, 3-benzodioxol-5-y1) me ti 1] -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin- 4-yl] piperazin-2-carboxamide; N- [(4-methyloxy) 1) met yl] -1- [(1, 3-benzodioxol-5-yl) met yl] -4- [2- (lH-imidazol-1-yl) -6 -methylpyrimidin-4-yl] piperazin-2-acetamide; N- [(4-methoxypheni.) Methyl] -l- [(1, 3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6- (iso-propyl) ) pyrimidin-4-yl] piperazin-2-acet amide; N- [2- (4-methoxyphex) ethyl] -1 - [(1,3-benzodioxol-5-yl) methyl] -4- [2- (lH-imide ol-1-yl) -6-methylpyrimidine- 4-yl] piperazin-2-acetamide; N- [[2- (phenyl) cyclopentyl] amino] -1- [(1,3-benzodioxol-5-yl) me tyl] -4- [6-chloro-2- (.H-imidazol- 1-yl) pyrimidin-4-yl] piperazin-2 -carboxamide; N- [(4-Ethoxyphenylmethyl] -1- [(1,3-benzodioxan-6-yl) me ti 1] -4- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4- il] piperazin-2-acet amide; N- [(1,3-benz odi-oxol-5-yl) methyl] -1- [(1,3-benzodioxan-6-yl) methyl] -4- [2 - (lH-imidazol-1-yl) -6- (iso-propyl) pyrimidin-4-yl] piper a zin-2 -acet amide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(1,3-benzodioxan-6-yl) methyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-y1] piperazin-2-acetamide; N- [(1 , 3-benzodioxol-5-yl) methyl] -l- [(1,3-benzodioxan-6-yl) methyl] -4- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] piperazine -2-carboxamide; N- [2- (1, 3-benzodioxol-5-yl) ethyl] -1- [(1,3-benzodioxan-6-yl) met i 1] -4- [2- (lH -imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [2- (1,3-benzodiox-5-yl) ethyl] -l- [(1,3-benzodioxan - 6-yl) met i 1] -4- [2- (lH-imide ^ ol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-carboxamide; N- [(4-methoxyphenyl) methyl] -l- [(1, 3-benzodioxan-6-yl) methyl] -4- (lH-imidazol-1-i. ) - 6-chloropi r imidin-4-yl] piperazin-2-acetamide; N- [(3,4-dimethoxy fe Ul) methyl] -1- [(1, 3-benzodioxan-6-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6- ( iso-propyl) pi r imidin-4-yl] piperazin-2-acetamide; N- [(3, 4-dimethoxy fa Ul) methyl] -l- [(1, 3-benzodioxan-6-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6- chloropyrimidin-4-yl] piperazin-2-acet amide; N- [2- (1, 3-benzodicxol-5-yl) ethyl] -1- [(pyrimin-3-yl) me t yl] -4- [2- (lH-imidazol-1-yl) - 6-methylpyrimidin-4-yl] piperazin-2-acet amide; N- [(1,4-benzodioxan-6-y1) me ti 1] - 1 - [(pyridin-3-yl) methyl] -4- [2- (lH-imidazol-l-yl) pyrimidin-4 -yl] piperazine-2-carboxamide; N- [2- (1, 4-benzodixoan-6-yl) ethyl] -l- [(pyridin-3-yl) methyl] -4- [2- (lH-imide.:ol-l-il) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [(4-methoxy phenyl) ethyl] -1- [(pyridin-3-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6-cl ??: opyrimidin-4- il] piperazine-2-carboxamide; N- [(3,4-dimethoxyphene) methyl] -1- [(pyridin-3-yl) methyl] -4- [2- (lH-imide zol-1-yl) -6- (iso-propyl) pyrimidin-4-yl] piperazin-2-acetamide; N- [2- (3,4-Di methoxyphenyl) ethyl] -1 - [(3-fluoro-4-methoxyphenyl) methyl] - A - [2- (lH-imidazol-1-yl) -6- (isopropyl ) pyrimidin-4-y1] pipera: .in-2-acet amide; N- [3- (3,4-dimetho-> ifenyl) propyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2 - (lH-imidazol-1-yl) -6- (i sopropil) pyrimidin-4-yl] pipera-2-acetamide; N- [(4-ethoxyphenyl) methyl] -1- [(3-fluoro-4-methoxy-phenyl) methyl] -4- [2- (lH-yl my dazol-l-yl) -6-met ilpyr imi din-4-yl] pipera zin-2 -acetic acid; N- [2- (4-Methylphenoxy) ethyl] -1- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (1H- _ da zol-1-yl) -6-chloropyr imidin- 4-yl] piperazin-2 -acetic acid; N- [(4-methylphenyl) methyl] -l- [(3-fluoro-4-me t-oxy phenyl) methyl] -4- [2- (1H-mida zol-1-yl) -6- Chloropyrimidin-4-yl] piperazin-2 -acetic acid; N- [(4-chlorophen Ll) methyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-imide zol-l-yl) -6-met ilpyr imi din - 4-yl] piperazin-2-acet amide; N- [(4-chlorophenyl) methyl] -1- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-i my da zol-l-yl) -6-chloropyr imidin- 4-yl] piperazin-2-acetamide; N- [(1, 3-benzodio> g-ol-5-yl) methyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-mida zol-l- il) -6-chloropyr imidin-4-yl] piperazin-2-acet amide; N- [2- (1, 3-benzodi-xol-5-yl) ethyl] -1- [(3-fluoro-4-methoxy phenyl) ethyl] -4- [2- (1H-. -l-il) -6-met ilpyr imidin-4-yl] piperazin-2-acet amide; N- (2- (1, 3-benzodUxol-5-yl) ethyl] -l - [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- ('. H-imidazol-1-yl) pyrimidin-4-yl] piper a zin-2-acet amide; N- [2- (1, 4-benzodi txan-6? L) ethyl] -l- [(3-fluoro-4-methoxyphenyl) methyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperazin-2-acet amide; N- [2- (4-methoxyphenyl) ethyl] -1- [(3-fluoro-4-methoxyphenyl) methyl] -A- [2- (lH-imidazol-1-yl) -6- (isopropyl) pyrimidine- 4-yl] piperazine-2-acetamide; N- [(3,4-dimethoxyphen 1) ethyl] -l-acetyl-4- [2- (IH-imidazol-1-yl) -6- (iso-propyl) pyrimidir-4-yl] pipera zin-2 -acetamide; N- [(4-ethoxy phenyl) -yl] -l-acetyl-4- [2- (lH-imidazol-1-yl) -6- (iso-propyl) pyrimidin-yl] p? Perazin-2 carboxamide; N- [2- (4-methyl-enoxy-ethyl] -l-acetyl-4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] pip-2-acetamide; N- [ 2- (3-chloro-4-met-JXI-phenyl) -ethyl] -l-acetyl-4- [2- (1H-imi-zol-1-yl) -6-chloropyrim (? N-4-yl) pipe-ration -2-carboxamide; N- [(1,3-benzodioxcl-5-yl) methyl] -l-acetyl-4- [2- (1H-imidazol-1-yl) -6-methylpyrimic? N-4-yl ] piperazin-2-acetamide; N- [(4-methoxyphenyl) methyl] -l-acetyl-4- [2- (lH-imidazol-1-yl) -6-met-ilpyrimidin-4-yl] pip was zi n-2 -carboxamide; N- [(4-methoxyphenyl) methyl] -l-acetyl-4- [2- (lH-imidazol-1-yl) -6-chloropyrimidin-4-yl] pii erazin -2-acetamide; N- [2- (3, 4-dimethoxy-nyl) ethyl] -1- (3-methyl-1-oxobutyl) -4- [2- (1 H-imidazol-1-yl) -6 - (iso-propyl) pir imidin-4-yl] pipera zin-2-acetamide; N- [2- (3, 4-dimeroxif < nil) ethyl] -1- (3-methyl-l-oxobutyl) -4- [2- (lH-imide zol-1-yl) -6-cl oropyrimidine -4-yl] piperazine-2-carboxamide; N- [2- (3-chloro-4-n-toxyphenyl) ethyl] -l- [3-met il-1-oxobutyl) -4- [2- (lH-imida-ol-1-yl) -6- Chloropyrimidin-4-yl] piperazin-2-carboxamide; N- [2- (3-chloro-4-retoxyphenyl) ethyl] -l- (3-met il-1-oxobutyl) -4- [2- (lH-imide ol-1-yl) -6-methylpyrimidin- 4-yl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- (3-met il-1-oxobutyl) -4- [2- (lH-imide zol-1-yl) pyrim. iin-4-yl] piper a zin-2 -carboxamide; N- [(1,3-benzodioxol-d-yl) methyl] -1- (3-methyl-il-1-oxobutyl) -4- [2- (lH-imidazol-1-yl) -6-p-ethylpyrimidine -4-yl] piperazine-2-carboxamide; N- [2- (1,3-benzodio? Tn-6-yl) ethyl] -1- (3-methyl-l-oxobutyl-4- [2- (lH-imidazol-1-yl) -6- c .. oropyrimidin-4-yl] piperazine-2-carboxamide; N- [(1,4-benzodioxan-d-yl) methyl] -1- (3-met il-1-oxobutyl) -4- [2- (lH-imidazol-1-yl) -6-c-oropyrimidin-4-yl] piperazine-2-carboxamide; N- [2 (1,4-benzodixol X-yl) ethyl] -1- (3-met il- 1-oxobutyl) -4- [2- (1H-imidazol-1-yl) -6-c-loropyrimidin-4-yl] piperazine-2-carboxamide; N- [2 (1,4-benzodixol-S-yl) ethyl] -1- (3-methyl-1-oxobutyl) -4- [2- (1H-imidazol-1-yl) -6- (trifluoromethyl) pyrimidin-4-yl] piper a zin-2-acet amide; N- [(2,6-dimethoxy phen 1) methyl] -1- (3-met il-1-oxobutyl) -4- [2- (lH-imidazol-1-yl) -6-c orop i ' midin-4-yl] piperazin-2-acetamide; N- [2- (3, 4-dimethoxy-enyl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imide zol-1-yl) -6- (iso-p-opyl) pyrimidine- 4- il] piperazin-2-acetamide; N- [2- (1, 3-benzodiox-l, 5-yl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-met lpyrimidin-4-yl] piperazine-2-carboxamide; N- [2- (1, 3-benzodio-1-5-yl) ethyl] -1- (methoxyacetyl) -A- [2- (lH-imide zol-1-yl) -6-chloropi? Lidin-4-yl] piperazin-2-acet amide; N- [2- (1, 3-benzodioxc 1-5-yl) ethyl] -1- (methoxyacetyl) -4- [2- (1 H-imidazol-1-yl) -6- (trifluoro-omethyl) -pyridin - 4-yl] piper to zin-2-acetamide; N- [(3,4-dimethylpheni) methyl] -1- (methoxyacetyl) -4- [6- (1H-imidazol-1-yl) -6- (trifluoroxethyl) pyrimidin-1-yl] piperazine-2-carboxamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6- (iso-p-opyl) pyrimidin-4-yl) ] piperazin-2-acetamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- (methoxyacetyl) -4- [2- (lH-imide zol-1-yl) -6- (iso-p-opyl) -pyridin-4 -yl] piperazine-2-carboxamide; N- [2- (1,4-benzodiox-n-6-yl) ethyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6- (trifluo-omethyl) pyrimidine- 4-yl] piperazin-2-acetamide; N- [(-methoxy phenyl) -. ethyl] -1- (methoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-acet amide; N- [2- (3,4-dimethoxy-yl) ethyl] -l- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imic azol-1-yl) -6- Chloropyrimidin-4-yl] piperazin-2-carboxamide; N- [(4-methylphenyl netyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imic azol-1-yl) -6-chloropyrimidin-4-yl] pipera zin - 2 -acet amide: N- [2- (4-chlorophen: L) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imic -i zol-1-yl ) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [(3-chloro-4-methox: phenyl) methyl] -1- [(tetrahydrofuran-2-yl] carbonyl] -4- [2 - (lH-imic isol-l-yl) -6-chloropyrimidin-4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [(tetrahydrofuran-2) -yl) carbonyl] -4- [2- (lH-imidazc-1-yl) pyrimidin-4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol 5-yl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [6- (lH-imidazc Ll -yl) pyrimidin-4-yl] piperazine- 2-carboxamide; N- [2 (1,3-benzodioxo-5-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (1H-imidazo-1-yl) -6-pyrimidine- 4-yl] piperazin-2-acetamide; N- [2- (1, 3-benzodioxc L-5-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazc i-1-yl) pyrimidine- 4-yl] piperazin-2-acetamide; N- [2 (1,3-benzodioxo-5-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazc-l-yl) -6- ( iso-propyl) pyrimidin-yl] piperazin-2-acetamide; N- [2 (1,3-benzodioxo-5-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imic azol-1-yl) -6-methylpyrimidine -4-yl] piperazine-2-carboxamide; N- [(1,4-benzodioxol-6-yl) methyl] -l- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazc.-1-yl) -6- (iso -propyl) pyrimidin-4-yl] piperazin-2-acetarr da; N- [(1,4-benzodioxan-Xyl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imid zol-1-yl) -6- (chloropyrimidine- 4 -yl] piperazine-2-acetamide; N- [(1,4-benzodioxan-Xyl) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imic? zol-1 -yl) -6-chloropyrimidin-4-yl.} piperazine-2-carboxamide; N- [2- (1, 4-benzodioxa-6-yl) ethyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -A- [2- (IH-imic, azol-1-yl) - 6-methylpyrimidin-4-yl} piperazin-2-carboxamide; N- [(4-methoxyphenylmethyl]] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imic azol-1-yl) -6-chloropyrimidin-4-yl] piperazin-2-acetamide; N- [2- (4-methoxypheni) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imic azol-1-yl) -6 -chloropyrimidin-4-yl] piperazine-2-carboxamide; N- [2- (3-methoxyphenyl) ethyl] -l- [(tetrahydrofuran-2-yl) carbonyl] -A- [2- (lH-imic azole - 1-yl) -6-chloropyrimidin-4-yl] piperazin-2 -carboxamide; N- [(1,4-benz odi oxan- 'yl) methyl] -l- [(tetrahydrofuran-2-yl) ) carbonyl] -4- [2- (lH-imidazc-1-yl) -6- (iso-propyl) pi r imidin-4-yl] piperazine-2-carboxamide; N- [(3,4-dimethoxifer 1 ) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] -4- [2- (lH-imidazc-l-yl) -6- (iso-propyl) pi r imidin-4-yl] pipera zin - 2-acetamide: N- [(3,5-dimethoxy fer. 1) methyl] -1- [(tetrahydrofuran-2-yl) carbonyl] - - [2- (lH-imic? Zol-1 -yl) - 6-chloropyrimidin-4-yl] piperazin-2-acetazole; N- [(4-ethoxyphene-1) methy1] -1- [(2-hydroxy-2-oxoet) oxy) acetyl] -4- [2- (lH-ii da zol-l-yl) -6-chloropyr imidin-4-yl] piperazine-2-carboxamide; N- [(3-chloro-4-methoxyphenyl) methyl] -1- [(2-hydroxy-2-oxoethoxy) acetyl] -4- [2- (lH-i-idazol-1-yl) -6- chloropyrimidin-4-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxc L-5-yl) methyl] -1- [(2-hydroxy-2-oxoethoxy) acetyl] -4- [2- (lH-i: idazol-1-yl) - 6-methylpyrimidin-4-yl] piperazine-2-carboxamide; N- [2- (3,4-dimethoxy-nyl) -ethyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-methylpi? .midin-4-yl] piperazin-2-acetamide; N- [3- (3, 4-dimethoxife XI) propyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-cioropi? .midin-4-yl] piperazin-2-acetamide; N- [(4-methyl phenyl) methyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol-1-yl) -6-methylpyrimic ..n-4-yl] piperazine-2-acetamide; N- [(1,3-benzodioxol- "> -il) methyl] -1- (phenoxyacetyl) -4- [2- (1H-imidazol-1-yl) pyrimidin-1-yl] piperazine-2-carboxamide; N- [(1,3-benzodioxol- -yl) methyl] -1- (phenoxyacetyl) -4- [6- (1H-imidazol-1-yl) pyrimidin-1-yl] piperazine-2-acetarrudate; N - [2- (1, 3-benzodioxo-5-yl) ethyl] -1- (phenoxyacetyl) -4- [2- (1H-imidazol-1-yl) pyrimidin---yl] piperazin-2-acetamide; N- [2- (1,3-benzodioxo-5-yl) ethyl] -1- (phenoxyacetyl) -4- [2- (lH-imide zol-1-y1) - 6-chlor op id imide n- 4-i 1] p ipe ra z in-2 -carboxamide; N- [(1,4-benzodioxan-> -yl) methyl] -1- (phenoxyacetyl) -4- [2- (lH-imidazol- 1-yl) -6-chloropi? .midin-4-y1] piperazin-2-acetamide; N- [2- (1,4-benzodioxa-5-yl) ethyl] -1- (phenoxyacetyl) -4- [ 2- (lH-imidazol-1-yl) -6-chloropi-midin-4-yl] piperazin-2-acetamide; N- [(4-methoxyphenyl) rt.] -1] (f-enoxyacetyl) -4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl Xperazin-2-acetamide; N- [(4-methoxy phenyl) tyl] -1- (phenoxy to cetyl) -4- [2- (lH-imidazol-1-yl) -6-chloropyrimic in-4-yl] piperazin-2-carboxamide; N- [2- (4-methoxyphenyl)] -1- (f-enoxyacetyl) -4- [2- (1H-imidazol-l-yl) -6-methylpyrimic-4-yl] piperazin-2-acetamide; N- [2- (4-methoxy phenyl ethyl] -1- (f-enoxyacetyl) -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl "Xperazin-2 -acetamide; N- [ 2 - (3,4-dimethyl f-ethyl) -1- [(4-methoxyphenyl) carbonyl] -4- [2- (1-imidazol-1-yl) -5-chloropyrimidin-4-yl] piper a zin- 2 -acet amide; N - [(1, 3-benzodioxolX-yl) methyl] -4- (6-f luoropyridin-2-yl) -1- [2- (lH-imide zol -1- il) pi imidin-4-yl] piper to zin-2 -aceta-like; 1- (acetyl) -4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4 -methylsulfonylphenyl) methyl "? perazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl.} - N - [(4-methylsulfonylphenyl) methyl] pipe idin-2- acetamide; N- [(1,3-benzod L-oxol-5-yl) methyl] - A - [[2- (ethoxycarbonyl) methyl] -1- [2 - (lH-imidazol-l-yl) pyrimidin-4 -yl] piperazin-2-acetamide; 4- [amino (imino) metX-N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imide zol-1-yl) pi rim iin-4-yl] pipera zin-2-acet amide; 1-Methylsulfonyl- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 4-) enz odi oxan-6-yl) ethyl] pipera zin-2-acetamide;1-met ilsul foni 1-4- [2 (1H-imidazol-1-yl) pyrimidin-4-yl} -N- { 2- (1,4-benzodioxan-6-yl) < ?] pipe razin-2 -acet amide; 1-methylsulfonyl- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2-X-methoxyphenyl) ethyl] piperazine-2-acetamide; l-methylsulfonyl-4-6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-xmethoxyphenyl] methyl] piperazine-2-acetamide; - (n-octyl) f ílfon:? -4 - [6-met il-2 - (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3, -dimethoxy-enyl) ethyl ] piperazin-2-acetamide; 1- (n-octyl) sulphon:.-A- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [X-CIOJ] J-4-methoxyphenyl) methyl] piperazine-2-acetamide; 1- (n-octyl) suí fonil- - [6-lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxc'-5-yl) piperazin-2-acetamide; 1- (n-octyl) sulfon. 4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3- ^ enzodioxol- 5-yl) ethyl] piperazin-2-acetamide; 1- (n-octyl) sulfon: L- 4 - [6-methyl 1-2 - (lH-imidazol-1-yl) pyrimidin-4-yl] - N- [2- (1, 4-jenzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (n-octyl) sulfon: L-4- [6-methyl-2- (lH-imidazol-1 -yl) pyrimin-4-yl] -N- [2- (3-methoxyphenyl) methyl] piperazin-2-acetamide; 1- (n-octyl) sulfon: 1-4- [6-met il-2- (1 H-imide zol-1-yl) pyrimin din-4-yl] -N- [(4-f) lorophenyl) sulfonyl] piperazin-2-acetamide; 1- (4-methyl phenyl) sul on il-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(pi Xdin-3-yl) methyl] piperazine-2-carboxamide; 1- (4-methylphenyl) sul "Dnyl-4- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] piperazine -2-carboxamide; 1- (4-methylphenyl) sul onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin din-4-yl] -N- [(3, 4- lime toxy phenyl) methyl] piperazine-2-carboxamide; 1- (4-methoxyphenyl) SUJ 2onyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2 - (3, -dimethoxyphenyl) ethyl] piperazin-2-acetamide; 1- (4-methoxy phenyl) su: onyl-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidine- 4- il] -N- [(1,3-b nz odi oxol-5-yl) me useful] piperazine-2-carboxamide; 1- (4-methoxyphenyl); ulfonyl-4- [2- (lH-imidazol- 1-yl) pyrimidin-4-yl] -N- [2- (1, 3 -) -enoxodioxol-6-yl) ethyl] piperazine-2-carboxamide; 1- (4-methoxyphenyl) -sulfonyl-4- [ 2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3) -cyclodol-5-yl) ethyl] piperazin-2-acetamide; 1- (4-methoxy phenyl) sul onyl-4- [6-met il-2- (lH-imide zol-l-yl) pyrimin din-4-yl] -N- [(3,4-limetoxyphenyl) methyl ] piperazin-2-acetamide; 1- (4-methoxy phenyl sul onyl-4- [6-met i 1-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (l, 4- > enzodioxan -6-yl) ethyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) -l-lfonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4) -yl] - N - [(4-methoxy phenyl) methyl] piperazin-2-carboxamide; 1- (4-methoxy-enyl) -ul on on 1 - 4 - [2 - (lH-imide zol-1-yl) pyrimidin-4-yl] - N - [(2-ethoxyphenyl) methyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) sul "onyl -4- [6-met il-2- (lH-imide zol -l-yl) pyrimidin-4-yl] -N- [2-X-methoxyphenyl) ethyl] piperazin-2-acetamide; 1- (4-methoxy phenyl) su: Xnil-4- [6 -chloro- 2 - (1H-imide zol-1-yl) pyrimidin-4-yl] -N- [2-X-methoxyphenyl) ethyl] piperazine-2-carboxamide; 1- (4-methoxyphenyl) sul: onyl-4- [6 -methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3, 4-imethoxy-phenyl) -methyl] -piperazine-2-carboxamide; 1- (4-methoxyphenyl) -i? lfonyl-4- [6-iso-propyl-2- (1H-imi da zol-1-yl) pyrmidin-4-yl] - N - [(3,4-dimetre oxy phenyl) methyl] piperazir-2-carboxamide; 1- (4-methoxy phenyl) its! : onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-limetoxyphenyl) methyl] piperazine-2-carboxamide; 1- (4-f luoro phenyl) sulphonyl 4- [6-chloro-2- (lH-imidazol-1-yl) pir imidin-4-yl] -N- [2- (1, 3-) enzodioxol -5-yl) ethyl] pipera zin-2-acetamide; 1- (Fluorophenyl) s lfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-enzodioxan-6-yl) ethyl] pipera zin -2-acetamide; 1- (dimethylamino) sul onyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methyl) phenyl) methyl] pipera zin-2 - acet amide; 1- (dimethylamino) -helonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-cl r o- 4 -me toxy phenyl) ethyl] piperazin-2-acetamide; 1- (dimethylamino) sul onyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-b nzodioxo 1-5-yl) me useful] pipera zin-2-acetamide; 1- (dimethylamino) s? Lfonil-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-b nzodioxol-5-yl) methyl] pipera zin- 2-carboxamide; 1- (dimethylamino) sul onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3 > in zodioxol- 5- il) ethyl] pipera zin-2-acetamide; 1- (dimethylamino) e? Lfonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-b nzodioxan-6-yl) methyl] pipera zin- 2-acetamide; 1- (dimethylamino) sul onyl-4- [6-trif luoromethyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide a; 1- (dimethylamino) s lfonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4 Ul] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamid; 1- (dimethylamino) sul onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 4-enzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (dimethylamino) sul onyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- ('-methoxyphenyl) ethyl] piperazin-2- acetamide; 1- (dimethylamino) s lfonyl-4- [6-iso-propyl-2- (1H-i m i d a z or l-1-i l) p i r m i d i n-4-i l] - N - [(3, A-dimethoxyphenyl) methyl] piperazi. - 2 -a cet ami da; 1- (n-propyl) aminoca: > onyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N- [2- (3, -dime :: oxy phenyl) ethyl] pipera zin-2 acetamide; 1- (n-propyl) aminoca: jonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (l -methyl phenoxy) ethyl] piperazine -2-carboxamide; 1- (n-propyl) aminocaj) onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (-chlorophenyl) ethyl] piperazin-2 -carboxamide; 1- (n-propyl) aminocay) onyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] pipe ra zin-2-acetamide; 1- (n-propyl) aminocay) onyl-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [2- (3-cl r- 4 -me toxy phenyl) ethyl] pipera zin-2-carboxamide; 1 - (n-propyl) aminoc irboni 1 -4 - [6-i so-propyl-2 - (1H-imidazol-1-yl) pyrimidine-! - i 1] -N- [(1,3-benzodioxol-5-yl) methyl] pipera zin-2 -carboxar ida; 1- (n-propyl) aminocaj > onyl-4- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(1,3-b nzodioxol-5-yl) methyl] pipe-2- carboxamide; 1- (n-propyl) aminocayonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pir imidin-4-yl] -N- [(1,3-b nzodioxol-5- il) methyl] pipera zin-2-acetamide; 1- (n-propyl) aminoca:) onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pir imidin-4-yl] -N- [2- (1, 3-) enzodioxol -5-yl) ethyl] piperazine-2-carboxamide; 1- (n-propyl) aminoca:; onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pir imidin-4-yl] -N- [2- (1, 3- jenzodioxol- 5-yl) ethyl] piperazin-2-acetamide; 1- (n-propyl) aminc-arbonyl-4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3-) eno-dioxol-5-yl) ethyl ] pipera zin-2-carboxamide; 1- (n-propyl) aminoc arbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidine-! -i 1] -N- [(1,4-benzodioxan-6-yl) methyl] pipera zin-2 -carboxar '.da; 1- (n-propyl) aminc arbonyl-4- [2- (lH-imidazol-1-yl) pyrimin-4-yl] -N- [2- (1, l-benzodioxan-6-yl] piperazine- 2-carboxamide; 1- (n-propyl) aminoca. -onyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin din-4-yl] -N- [(3,4- methoxyphenyl) methyl] piperazin-2-acetamide; 1- (cyclohexyl) aminoc-rbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-dimethoxyphenyl) ethyl] piperazin-2-acetamide; 1- (cyclohexyl) aminot-rbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(- -ethoxy phenyl) methyl] piperazine-2-carboxamide; 1- (cyclohexyl) amii) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-Cl ro- 4 -me toxy phenyl) ethyl] piperazin-2-acetamide; 1- (cyclohexyl) amin carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimid n-4-yl] -N- [2- (3-chloro-4-me toxy) phenyl) ethyl] pipe razin-2-acetamide; 1- (cyclohexyl) aminoc-rbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3- in zodi-oxol-5-yl) ) methyl] piperazin-2-acetamide; 1- (cyclohexyl) amylcarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (l, 3-) eno-dioxol-5-yl) ethyl] piperazine- 2-acetamide; 1- (cyclohexyl) ami'ocarbonyl-4- [6 (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3-jenzodioxol-5-yl) ethyl] piperazin- 2-carboxamide; 1- (cyclohexyl) amin carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl) ] pipera zin-2 -carboxai Ida; 1- (cyclohexyl) aminoi. Rbonyl-4- [6-met il-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [(1,4-enzodioxan-6-yl) methyl] piperazine-2-carboxamide; 1- (cyclohexyl) aminoc. Rbonyl-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [(1,4-enzodioxan-6-yl) methyl) ] pipera zin-2 -carboxamide; 1- (cyclohexyl) aminocubonyl-4- [6-chloro-2- (IH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-enzodioxan-6-yl) methyl] piperazin -2-acetamide; 1- (cyclohexyl) amino. .rbonyl-4- [6-trif luoromet i 1-2- (1H-imidazol-1-yl) pyrimidine-. - i 1] - N - [(1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamidr; 1- (cyclohexyl) aminoc i rbonyl- 4- [6-chloro-2- (lH-imide zol-l-yl) pyrimin din-4-yl] -N- [2- t -methoxyphenyl) ethyl] piperazin-2 -carboxamide; 1- (cyclohexyl) aminoc-rbonyl-4- [6-methyl-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-enzodioxan-2-yl) methyl] piperazine-2-carboxamide; 1- (cyclohexyl) amin oarbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-1-yl] -N - [(1,4-benzodioxan-2-yl) methyl) ] piperazine-2-carboxy-ida; 1- (cyclohexyl) amin carbonyl-4- [6-iso-propyl-2- (1 H -i? Idazol-1-yl) pyrmidin-4-yl] - N - [(2,3-dimethoxy phenyl) methyl] piper azi; -2 -carboxamide; 1- (cyclohexyl) aminoc i rbonyl- 4- [6-chloro-2- (lH-imide zol-1-yl) pyrimin din-4-yl] -N - [(2,2-dimethoxyphenyl) methyl] piperazine- 2-carboxamide; 1- (phenylsulfonyl) < ninocarbonyl-4- [6-chloro-2- (1H-imide z ol-1-yl) pi ri i di n-4-yl] -N - [2 - (3,4-dimethoxy phenyl) ethyl] piperazine - 2 -acet amí da; 1- (phenylsulfonyl). ainocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(4-ethoxyphenyl) methyl] piperazin-2-acetamide; 1- (phenylsulfonyl) arcarbonyl-4- [2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] piper a zin-2 -acet amide; 1- (phenylsulfonyl) ninocarbonyl-4- [6-chloro-2- (1H-i m i d a z or l-1-i l) p i r m i d i n-4-i l] - N - [2 - (4-methylphenoxy) ethyl] piperazin-2-acetamide; 1- (phenylsulfonyl) c ninocarbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(4-methylfenyl) methyl] piperazin-2-acetamide; 1- (phenylsulfonyl) < ? inocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimid n-4-yl] -N- [2- (3-chloro-4-methoxyphenyl) ethyl] piperazin-2-acetamide; 1- (phenylsul fonyl) c-ninocarbonyl-4 - [6-methyl-2 - (1H-imidazol-1-yl) pyrimidin-1-y1] - N - [(1,3-benzodioxol-5-yl) methyl] ] piperazin-2-acetam a; 1- (phenylsulfonyl), ninocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazine -2-carboxa ^ da; 1- (phenylsulfonyl) r ninocarbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] pipera zin- 2 -carboxar ¡.da; 1- (phenylsulfonyl), ninocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazine -2-acetamyl '-i, -1- (phenylsulfonyl), ainocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrim? Din-¿l] -N- [2- (1 , 4-benzodioxan-6-yl) ethyl] piperazin-2-acetamid; 1- (phenylsulfonyl) ai .carbonyl-4- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (1, 4-) enzodioxan-6-yl) ethyl] pipera zin ^ -acetamide; 1- (phenylsulfonyl) < ninocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] N - [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- (phenylsulfonyl), ninocarbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrmidin-4-yl] - N - [(2,5-dimethoxyphenyl) methyl] pipe razi '-2 -acetamide; l- [2- (Thien-2-yl) ethyl -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-y) methyl] ] piper a zin -2 -carboxamide; l- [2- (Thien-2-yl) et 1] -4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3- b nzodioxol-5-yl) methyl] piperazin-2-carboxamide; l- [2- (Thien-2-yl) ethyl -4- [6-? so-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 4- t nz odi oxan-6-yl) methyl] piperazin-2-acetamide; l- [2- (Thien-2-yl) et l] -4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 4 -t nzodioxan-6-yl) methyl] pipera zin-2-carboxamide; l- [2- (thien-2-yl) et l] -4- [6-chloro-2- (lH-imide zol-l-yl) pyrimyne-4-yl] -N- [(2,3 - li methoxyphenyl) methyl] piperazine-2-acetamide; 1- [2- (thien-2-yl) etiJ -4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclo-ro-pyl) methyl] ] piperazin-2-acetamide; 1- (4-methoxy phenyl) ninocarbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl-N - [(4-chloro-enyl) methyl] piperazine-2-carboxamide; 1- (4-methoxyphenyl) ai Anocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (2, -dimethoxy-enyl) ethyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) n -carbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ) methyl] pipera zin-2-carboxa Lda; 1- (4-methoxy-enyl) -ai -carbonyl-4- [2- (lH-imidazol-1-yl) -pyridin-4-yl] -N- [2- (1, 3-) -cyclodol-5-yl) ethyl] piperazin-2-acetamide; 1- (4-methoxy phenyl) ai .carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-t nzodioxan-6-yl) methyl] piperazine-2-carboxamide; 1- (4-methoxyphenyl) ninocarbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazine -2-carboxy .da; 1- (4-methoxyphenyl) -nocarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-1-yl] -N- [2 - (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamid '; 1- (4-methoxyphenyl) ai r_carbonyl-4- [2- (1 H-imidazol-1-yl) pyrimidin-4-yl] - N - [(1, methoxyphenyl) methyl] piperazin-2-acetamide; 1- (3,4-dichlorophenoxycarbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyridin-4-yl] -N- [2- (3, 4-dimethoxyphenyl) ethyl] piperazin-2-acetamide; 1- (3,4-dichlorophenyl-aminocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3- ^ enzodioxol -5-yl) ethyl] piperazin-2-acetamide: 1- (3,4-dichlorophenyl) minocarbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1 , 4-b nzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- (3,4-dichloropheni aminocarbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-) il] N- [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- (3,4-dichlorophenyl) myocarbonyl-4- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,5-! Imethoxyphenyl) methyl] piperazine-2-carboxamide; 1- (methoxy) carboni -4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl ] -N- [2- (3, -dimethoxyphenyl) ethyl] piperazin-2-acetamide; 1- (methoxy) carboni -4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-) il] -N- [2- (3, -dimethoxyphenyl) ethyl] piperazine-2-carboxamide; 1- (methoxy) carboni -4 - [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] - N - [(3-cyano) -4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- (methoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-chloro- 4 -me toxy phenyl) ethyl] piperazin-2-acetamide; l- (methoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1- -1) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazin-2-acetamide; 1- (methoxy) carbonyl-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl ] piperazin-2-acetamide; 1- (methoxy) carbonyl -4- [2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [2- (1, 4-benzodioxan-6-yl) ethyl] pipera zin- 2-carboxamide; 1- (methoxy) carbonyl-4- [2- (lH-imide zol-1-yl) py imidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] pipera zin -2 -acetamide; 1- (methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazine-2-carboxamide; l- (me toxi) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperazin-2- carboxamide; l- (methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] piperazin-2 -carboxamide; 1- (iso-propoxy) carbonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methylphenoxy) ethyl] piperazin-2 -carboxamide; 1- (iso-propoxy) carbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] piperazine-2-carboxamide; 1- (iso-propoxy) carbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazine-2-carboxamide; 1- (iso-propoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2 acetamide; 1- (iso-propoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazine-2-carboxamide; 1- (Iso-propoxy) carbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [[(3,4-dimethoxyphenyl) methyl] piperazine-2 -carboxamide; 1- (iso-propoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] piperazine- 2-carboxamide; 1- (iso-propoxy) carbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (cyclopropyl) piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2 acetamide; 1- (n-butoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 3-benzodioxol-5-yl) ethyl] piperazine- 2-acetamide; 1- (n-butoxy) carbonyl-4 [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl) ] piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2-acetamide; 1- (n-butoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] piperazin-2- acetamide; 1- (n-butoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazin-2- carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-iso-propyl-2- (1H-imide zol-1-yl) pyrimidin-4-yl] -N- [3- (4-dimethoxyphenyl) propyl] piperazine-2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole -5-yl) ethyl] piperazine-2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6) -yl) methyl] piperazin-2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6- (lH-imidazol-1-yl) pyrimin din-4-yl] -N- [(4-benz odi oxan-6-yl) methyl] piperazine-2-carboxamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan- 6 -yl) ethyl] pipera zin-2-acetamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazin-2-acetamide; 1- (2- (methoxy) ethoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-methoxyphenyl) ethyl] piperazine -2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methylphenoxy) ethyl] piperazin-2- acetamide; 1- ((phenyl) methoxy) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ) methyl] piperazin-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- ((phenyl) methoxy) carboni 1-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan- 6 -yl) ethyl] piperazine-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-meth i 1-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazin-2-acetamide; 1- ((phenyl) methoxy) carbonyl-4- [6-met il-2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazine -2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-iso-propyl-2- (1H-imi dazol-1-yl) pyri my din-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] piperazin-2-acetamide; 1- (4-methoxyphenyl) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazine -2-acetamide; 1- (4-methoxyphenyl) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin-2-acetamide; 1- (4-methoxyphenyl) carboni 1-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5- il) ethyl] pipera zin-2-carboxamide; 1- (4-methoxyphenyl) carbonyl-4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin-2 -acetamide; 1- (4-methoxy phenyl) carbonyl-4- [6-met i 1-2- (lH-imidazol-1-yl) pyrimin din-4-yl] -N- [(4-benzodioxan-6-yl) methyl] piperazine-2-carboxamide; 1- (4-methoxy phenyl) carbonyl-4- [6-met il-2- (lH-imide zol-l-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazin-2 -acetamide; 1- (4-methoxyphenyl) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] piperazin-2-carboxamide; l- (pyridin-3-yl) carbonyl-4- [6-met il-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [2- (3,4-dimethoxy phenyl) ethyl] piperazin-2-acetamide; l- (pyridin-3-yl) carbonyl-4- [6-chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ) methyl] piperazine-2-carboxamide; 1- (pyridin-3-yl) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piper to zin-2-acetamide; 1- (phenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; l- (Phenoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy-enyl) methyl] piperazine -2-carboxamide; 1- (4-methoxyphenoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,3-benzodioxol-5-yl) methyl] pipera zin- 2 -carboxamide; 1- (4-methoxyphenoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazin-2-carboxamide; l- (4-methoxyphenoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazine- 2-acetamide; 1- (4-methoxyphenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] pipera zin-2-carboxamide; 1- (4-methoxyphenoxy) carbonyl-4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] pipera zin- 2 -carboxamide; 1- (4-methoxyphenoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 4-benzodioxan-6-yl) ethyl] pipera zin -2 -carboxamide; 1- (4-methoxyphenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazin-2- acetamide; 1- (4-methoxyphenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N- [(2,4-dimethoxyphenyl) methyl] piperazin-2 -carboxamide; 1- (4-methoxy phenoxy) carboni 1-4- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxy phenyl) methyl] piperazine-2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-iso-propyl-2- (1H-i my dazol-1-yl) pyri my din-4-yl] - N - [2 - (4-methylphenoxy) ethyl] piperazine-2-carboxamide; l- ((phenyl) methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methylphenoxy) ethyl] piperazin-2 -carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] pipera zin- 2-carboxamide; 1- ((phenyl) methoxy) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ) methyl] piper to zin-2 -acet amide; l- ((phenyl) methoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] ] piperazin-2-carboxamide; 1- ((phenyl) methoxy) carboni 1-4- [6-met il-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol- 5-yl) ethyl] piper to zin-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl] pyridin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl) ] piperazin-2-acetamide; 1- (1-methylpropoxy) carbonyl-4- [5-chloro-2- (lH-imidazol-1-yl] pyrimidin-4-yl] -N- [(1, 3- benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- (1-methylpropoxy) carboni 1-4- [6- (lH-imide zol-l-yl] pyrimidin-4-yl] -N- [ (1,3-benzodioxol-5-yl) methyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidine- 4- il] -N-. {(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazole -1-yl] pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazin-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6- ( lH-imidazol-1-yl] pyridin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [ 2- (1H-imidazol-1-yl] pyrimidin-4-yl] -N- [1- (1, 4-benzodioxan-6-yl) ethyl] pipe ra zin-2-acetamide; (1-methylpropoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl] pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine-2-carboxamide; 1- (1-methylpropoxy) carbonyl-4- [6-methyl-2- (lH-imidazol-1-yl] pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] piperazin-2- acetamide; 1- (phenoxy) carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2- (3,4-dimethoxyphenyl) ethyl) ] piperazin-2-acetamide; 1- (phenoxy) carbonyl-4- [6-methyl-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N-. {2- (3, 4-dimethoxyphenyl) ethyl] piperazine-2-acetamide; 1- (phenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- ( 3,4-dimethoxyphenyl) ethyl] piperazine-2-acetamide; 1- (phenoxy) carbonyl-4- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3- benzodioxol-5-yl) methyl] piperazine-2-carboxamide; 1- (phenoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(furan-2- il) methyl] piperazin-2-acetamide; 1- (phenoxy) carbonyl-4- [6-met i 1-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 4-benzodioxan-6-yl) methyl] piperazine-2-carboxamide; l- (phenoxy) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 4-b Enzydoxan-6-yl) methyl] piperazine-2-carboxamide; 1- (phenoxy) carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,4-benzodioxan-6-yl) ethyl] piperazin-2- carboxamide; 1- (pyridin-3-yl) carbonyl-4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol- 5-yl) ethyl] piperazin-2-acetamide; l- (pyridin-3-yl) carbonyl-4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; l- (pyridin-3-yl) carbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1, 4-benzodioxan- 6 -yl) ethyl] piperazin-2-acetamide; l- (pyridin-3-yl) carbonyl-4- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [2- (4-methoxy phenyl) ethyl] piperazine-2-carboxamide; 1- [2- (4-methoxyphenyl) ethyl] -A- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N-2- (3-chloro- 4 -me toxy phenyl) ethyl] pipera zin-2-carboxamide; l- [2- (4-methoxy phenyl) ethyl] -4- [6-methyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol -5 -i 1) methyl] piperazine-2-carboxamide; 1- [2- (4-methoxyphenyl) ethyl] -4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol- 5-yl) methyl] pipera zin-2-acet amide; 1- [2- (4-methoxyphenyl) ethyl] -4- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5- il) methyl] piperazin-2-acetamide; l- [2- (4-methoxyphenyl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazine-2-carboxamide; 1- [2- (4-methoxyphenyl) ethyl] -4- [6-iso-propyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan- 6-yl) methyl] piper a zin- 2 -a ce tarruda; 1- [2- (4-methoxyphenyl) ethyl] -A- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piper to zin-2-carboxamide; 1- [2- (4-methoxy phenyl) ethyl] -A- [6-met il-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) me useful] piperazine-2-carboxamide; 1- [2- (4-methoxyphenyl) ethyl] -A- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperazine-2-carboxamide; 1- [2- (4-methoxyphenyl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimin-din-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazin-2 -carboxamide; 1- [(3,4-dichlorophenyl) methyl] carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pi imidin-4-yl] -N- [2- (3, A-dimethoxyphenyl) ethyl] piperazine-2-acetamide; 1- [(3,4-dichlorofenyl) ethyl] carbonyl-4- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylfine) ) methyl] pipera zin-2-carboxamide; l- [(3,4-Dichlorophenyl) methyl] carbonyl-4- [6-methyl-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzadioxole -5-yl) ethyl] piperazin-2-acet amide; 1- [(3,4-dichlorofenyl) ethyl] carbonyl-4- [6-chloro-2- (1H-imide z ol-1-yl) pir imi din- 4 -i 1] -N- [( 3, 4, 5 -tr ime tox ifenil) methyl] pipera zin-2 -carboxamide; 1- [(3,4-Dichlorophenyl) methyl] carbonyl-4- [6-chloro-2- (lH-i my dazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ) methyl] piperazin-2-carboxamide; l- [(1,3-Benzodioxol-5-yl) methyl] carbonyl-4- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (3 , 4-dimethoxyphenyl) ethyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [3- (3,4-dimethoxyphenyl) propyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-iso-propyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [3- (3, 4-dimethoxy-enyl) -propyl] -piperazin-2-acetamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5) -yl) methyl] piper to zin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-iso-propyl-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [( 1,3-benzodioxol-5-yl) methyl] pipe razin-2-carboxamide; l- [(1, 3-Benzodioxol-5-yl) methyl] carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole -5-yl) ethyl] piperazin-2-acetamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxole -5-yl] piperazin-2-acet amide; 1- [(1, 3-benzodioxol-5-yl) methyl] carbonyl-4- [6- (1H-imidazol-1-yl) pyrimidin-4-yl] ] -N- [2- (1, 3-benzodioxol-5-yl) ethyl] piperazin-2 -carboxamide; 1- [(1,3-benz odi-oxol-5-yl) methyl] -carbonyl-4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) met i lpiperazin-2-carboxamide; 1- [(1,3-benz odi oxo-5-yl) methyl] carbonyl-4- [6-met il-2 - (lH-imi da zol-1-yl) pi r imi di n-4-yl] -N - [(4 - methoxyphenyl) methyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6-iso-propyl-2- (lH-imidazol-l-yl) pyrimidine -4-yl] -N- [(4-methoxy phenyl) methyl] piperazin-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carbonyl-4- [6- (1H -imidazol-1-yl) pyrimidin-4-yl] -N - [(4-methoxy phenyl) methyl] piperazine-2-carboxamide; 1- [(1,3-benzodioxol-5-yl) methyl] carboni 1-4- [ 6-chloro-2- (lH-imi da z or l-1-i l) p i r imi d i n-4-i l] - N - (2-phenylcyclopropyl) pipera zin-2 -carboxamide; 1-methylsulfonyl-4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (1,3-benzodioxol-5-yl) ethyl] piperazine-2-carboxamide; N - [(3,4-dimethoxy phenyl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(3,4-dimethoxyphenyl) methyl] -1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] pyrrolidin-2-acetarruda; N - [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imide zol-l-yl) pyrimidin-4-yl] pyrrolidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidin-2-acetamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] pyrrolidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(3-chloro-4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidin-2-acetamide; N- [(3-chloro-4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N - [(4-methoxy phenyl) ethyl] -1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(3,4-dihydroxyphenyl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N-octyl-1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- (phenoxypropyl) -1- [2- (1H-imidazol-1-yl) -6-methyl-pyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(pyridin-3-yl) ethyl] -l- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N- [(morpholin-4-yl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidine-2-carboxamide; N - [(2 (methoxypyridin-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidine-2-carboxamide; N- [(2 ( methylpyridin-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidine-2-carboxamide; N- [(1,3-benzodioxol-5- il) ethyl] -2 - [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino} acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] ] -2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] acetamide; 2- [[- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] -N-octylacetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imide zol-l-yl) -6-methylpyrimidin-4-yl] (phenylmethyl) amino] acetamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -2- [[2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] amino] acetamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -2- [[2- (IH-imidazol-1-yl) -6-methylpyrimidin-4-yl] [(1,3-benzodioxol-5) -yl) methyl] amino] acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino} acetamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] [(morpholin-4-yl) ethyl] ] amino] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imidazol-1-yl) pyrimidin-4-yl] (methyl) amino] acetamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methylethyl) amino] acetamide; N- [(1,3-benz odi-oxol-5-oxy) ethyl] -2 - [[2- (lH-imide zol-l-yl) -6-methylpyrimidin-4-yl] (methyl) amino] acetamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -2- [[4- (lH-imide zol-1-yl) -6- (methylethyl) pyrimidin-2-yl] amino] acetamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -2- [[4- (lH-imide zol-l-yl) -6-methylpyrimidin-2-yl] amino] acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -3- [[2- (lH-imidazol-1-yl) -6-met ilpyrimidin-yl] amino] propionamide; 4- [(4-trifluoromethylphenyl) methyl] -3- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] propionamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -3- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] propionamide; N- [(1, 3-benzodioxol-5-oxy) ethyl] -2- (lH-imidazol-1-yl) pyrimidopyrimidin-4-amine; N- [(1,3-benzodioxol-5-yl) ethyl] -4- [1- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -l- (2-methyl-1- oxopropyl) piperazin-2-acetamide; N- [(4-methoxy phenyl) ethyl] -4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl) -6-methylpyrimidin-4-yl] -1- (2 - methyl-1-oxopropyl) piperidin-2-acetamide; N- [(4-nitrophenyl) methyl] -l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetamide; N- [[4- (acetylamino) phenyl] methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperazin-2-acetamide; N- [[4- (methylsulfonylamino) phenyl] methyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetamide; N - [(2,3-dihydrobenzofuran-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetamide; N - [(indan-5-yl) methyl} -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetamide; N- [(3-chloro-4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4- (1-oxopropyl) piperazine-2-acetamide; N- [(4-methoxyphenyl) aminocarbonyl] -1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-methanamine; N - [(1, 3-benzodioxol-5-yl) methylcarbonyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-methanamine; N- [(4-methoxyphenoxy) carbonyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl} piperidin-2-methanamine; N - [(4-methoxyphenyl) methylcarbonyl] -1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-methanamine; N- [(1,3-benzodioxol-5-yl) carbonyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] piperidin-2-ethanamine; 2,4-bis (lH-imidazol-1-yl) -6-methylpyrimidine; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) -5-methylpyrimidin-4-yl] -4- (phenylmethyl) piperazin-3- acetamide; N - [(3,4-dimethoxyphenyl) ethyl] -6- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N-me ti 1-5, 6, 7, 8-tetrahydropyrido [ 5, 6-c] pyrimidin-4-amine; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) methyl] -4-methylthiobutanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] -4-methylthiobutanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(4-methoxyphenyl) methyl] -4-methylsulfonylbutanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (butylthio) butanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N - [(c i c l or p r o p i l) m e t i l] - 3 - [(3,4-dimethylphenyl) methylthio] propanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(2,5-dimethoxy phenyl) methyl] -3-met il-3- [( phenylmethyl) thio] butanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N - [(4-chlorophenyl) methyl] -3-thiophenpropanamide; 5- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N - [(1,3-benzodioxol-5-yl) methyl] pentanamide; 5- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,4-benzodioxol-6-yl) ethyl] pentanamide; 7- [[2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [2-phenylcyclopropyl] heptanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] - [(3-chloro-4-methoxyphenyl) ethyl] acetamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] acetamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] amino] -N- [(1,4-benzodioxan-6-yl) ethyl] acetamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(4-methoxyphenyl) ethyl] acetamide; 4- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-yl] amino] -N- [(1,3-benzodioxol-5-yl) ethyl] butanamide; 2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] -N- [(4-chlorophenyl) ethyl] pyridine-3-propanamide; 2- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] isoquinoline-3-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] piperidin-2-acetard; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-methylphenyl) methyl] piperidin-2-acetarruda; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(2,4-dimethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] piperidin-2-acetamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] thiomorpholin-2-acetamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] thiomorpholin-2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] piperazine-2 -acetamide; 4- [(dimethylethoxy) carbonyl] -l- [2- (lH-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] piperazine -2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] piperazine-2-acetamide; 4- [(dimethylethoxy) carbonyl] -1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] pyrimidine-3-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] pyrimidine-3-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] pyrimidine-3-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] pyrimidine-3-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] pyrimidine-3-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) methyl] pyrimidin-3-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] piperidin-3-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] piperidin-3-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] piperidin-3-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] piperidin-3-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperidin-3-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] piperidin-3-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(2,4-dimethoxyphenyl) methyl] piperidin-3-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] piperidin-3-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] pyrrolidine-2-carboxamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] pyrrolidine-2-carboxamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-y1] -N- [(4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] -N- [(1,3-benzodioxol-5-yl) ethyl] acetamide; 1- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] (methyl) amino] -N- [(1,4-benzodioxan-6-yl) ethyl] acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) ethyl] -4-methylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) ethyl] -4-methylpiperazine-2-carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] -4-methylpiperazine-2-carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) ethyl] -4-methylpiperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4-methylpiperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-methylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-methoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-methoxyphenyl) methyl] -4-methylpiperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-methoxyphenyl) ethyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-pyrimidin-4-yl] -N- [[4- (2-methoxyethoxy) phenyl) methyl] -4-methylpiperazine-2-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-methylpiperazin-2-acetamide; 1- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(cyclopropyl) methyl] -4-methylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(indal-5-yl) methyl] -4-methylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,3-benzodioxol-5-yl) methyl] -4-butylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4-butylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-butylpiperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; l [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) ethyl] -4-butylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-butylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2- acetamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- [(-methoxyphenyl) methyl] piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(4-methoxyphenyl) methyl] piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(4- methoxyphenyl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- [(4-methoxyphenyl) methyl] piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] - A - [(4-methoxyphenyl) methyl] piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- [(4-methoxyphenyl) methyl] piperazine -2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-trifluoromethyl-4-yl] -N - [(2-phenylcyclopropyl) -4- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxy phenyl) methyl] piperazine- 2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(3,4-dichlorophenyl) methyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- [(3,4-dichlorophenyl) ) methyl] piperazin-2-acetamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(3, 4) phenyl) useful] piperazine-2-acetamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4 - [(3, 4 - dichlorophenyl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4 - [(3,4-dichlorophenyl) ) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- [(3,4-di chlorophenyl) me useful] pipera zin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) -pyridin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- [(3,4-dichlorophenyl) methyl] piperazine -2-acetamide; l- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4 - [(1,3-benzodioxol-5-yl ) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pi r imidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(1,3-benzodioxol- 5-yl) methyl] pipe razin-2-acet amide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(1, 3- benzodioxol-5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) ethyl] -4 - [(1,3-benzodioxole -5- il) met il] pipera z in-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4 - [(1,3-benzodioxol -5-yl) methyl] pipera zin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(1, 3- benzodioxol-5-yl) methyl] piper to zin-2-acet amide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(1, 3- benzodioxol-5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(1,3-benzodioxol-5- il) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4 - [(1, 3- benzodioxol-5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4 - [(1,3-benzodioxol-5- il) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4 - [(1,3-benzodioxol -5-yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- [(1,3-benzodioxol-5-yl) methyl] piperazin-2-acetamide; 1- [2- (1H-imide zol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(1,4-benzodioxan- 6-yl) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(1,4-benzodioxan-6-yl) ) methyl] pipera zin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4 - [(1,4-benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,5-dimethoxy phenyl) methyl] -4 - [(1,4-benzodioxan-6) -yl) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] - A - [(1, 4- benzodioxan-6-yl) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- [(1, -benzodioxan -6-yl) methyl] piper to zin-2-acet amide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- [(1,4-benzodioxan- 6- il) methyl] piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(1,4-benzodioxan-6-yl) methyl] pipera zin -2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4 - [(1,4-benzodioxan-6-yl) ) methyl] piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-thiophenyl) ethyl] -4 - [(1,4-benzodioxan-6-yl) methyl] piperazine- 2-acetamide; 1- [2- (lH-imide zol-1-yl) -6-trif luoromet ilpyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) methyl] -4- [(1,4-benzodioxan- ß-il) methyl] piperazin-2-carboxamide; 1- [2- (lH-imidazol-1-yl) -6-met ilpyr imidin-4 -i 1] -N- [(1-adamantyl) methyl] -4- [(1,4-benzodioxan-6 il) methyl] piperazine-2-carboxamide; 1- [2- (IH-imidazol-1-yl) pyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- [(1,4-benzodioxan-6-yl) methyl] piperazine- 2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- [(pyridin-3-yl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) propyl] -4- [(pyro-3- il) methyl] pipera zin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazin-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -A- [(pyridin-3- il) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -A- [(pyridin-3- il) methyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(pyridin-3- il) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4 - [(pyridin-3-yl) ) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridine- 3-yl) methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridin-3- il) methyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridin-3-yl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(pyridin-3-yl) ) methyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazin-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,6-dimethoxyphenyl) methyl] -4 - [(pyridin-3-yl) methyl] piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- [(piri di n-3 -yl) methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4- [(pyridin-3-yl) methyl] piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(3-fluoro-4 -methoxyphenyl) -methyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4 - [(3-fluoro- 4-methoxyphenyl) -methyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(3-fluoro-4-methoxyphenyl) ) -methyl] piperazin-2-acetamide; l- [2- (IH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(3-fluoro-4 -methoxyphenyl) -methyl] piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 4-benzodioxan-6-yl) ethyl] -4- [(3-fluoro-4-methoxyphenyl) -methyl] piper to zin-2 -acet amide; 1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- t-urene-phenyl) -ethyl] -4- [(3-fluoro-4-methoxy-phenyl) -methyl] -piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -A - [(3-fluoro-4-methoxyphenyl) methyl] piperazine -2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxypheniDmethyl] -4- [(3-fluoro-4-methoxyphenyl) methyl] piperazin-2- acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(l-adamantyl) methyl] -4- [(3-fluoro-4-methoxyphenyl) methyl] piperazine- 2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4- [(3-fluoro-4-methoxyphenyl)] methyl] piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4-acetylpiperazine- 2-acetamide: 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4-acetylpiperazine-2-acetamide; - [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H -imidazol-1-yl) -6-methylpyrimidin-4-y1] -N - [(4-ethoxyphenyl) methyl] -4-acetylpiperazine-2-acetacrudate; 1- [6-chloro-2- (1H-imidazole- 1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methylphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) ethyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [2- (1H-Imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(4-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(3,5-dimethoxyphenyl) ethyl] -4-acetylpiperazine-2-carboxamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4-acetylpiperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4,5-trimethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-acetylpiperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-1-yl] - N - [(1,4-benzodioxan-6-yl) ethyl] -4-acetylpiperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4-acetylpiperazine-2-acetarruda; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-difluorophenyl) ethyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4-acetylpiperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2-phenylcyclopropyl) -4-acetylpiperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) -4-acetylpiperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(indal-5-yl) methyl] -4-acetylpiperazin-2-acetamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (3-methyl-1-oxo-butyl) piperazine -2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin- -i1] - N - [(4-methoxyphenyl) methyl] -4- (3-methyl-1-oxobutyl) piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (3-methyl-l-oxobutyl) piperazin-2 -acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (3-methyl-l-oxobutyl) piperazin-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (3-methyl-l-oxobutyl) ) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (3-methyl-l-oxobutyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (3-methyl-l-oxobutyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (3-methyl-1) -oxobutyl) piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- (3-methyl-l-oxobutyl) pipera zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (3-methyl) -1-oxobutyl) piperazine-2-carboxamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (3-methyl-l-oxo-butyl) piperazine -2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (3-methyl-l-oxobutyl) piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (3-methyl-1) -oxobutyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (3-methyl-l-oxobutyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (3-methyl 1- 1-oxobutyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (3-methyl-1) -oxobutyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (3-methyl-1-oxobutyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (3-methyl-1-oxobutyl) piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- (3-methyl-l-oxobutyl) piperazin-2 -acculent; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (3-methyl-l-oxo-butyl) piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (3-methyl-1-oxobutyl) piperazine-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (3-methyl-l-oxobutyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-y1] -N- [([4- (2-methoxyethoxy) phenyl) ethyl] -A- (3-methyl-1-oxobutyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-2-yl) ethyl] -4- (3-methyl-1) -oxobutyl) piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(2-phenylcyclopropyl) ethyl] -A- (3-methyl-l-oxobutyl) piperazine-2-carboxamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxy phenyl) methyl] -4- (3-methyl-l-oxobutyl) piperazin-2-acetamide; l- [2- (1 H-imidazol-1-yl) pir imidi n-4-yl] -N- [(indal-2-yl) ethyl] -4- (3-met il-1-oxobutyl) piperazin -2 -carboxamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (indal-5-yl) ethyl] -4- (3-met il-1-oxobutyl) pipera zin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3, 4-dimethoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) ) piperazin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (2-methoxy-1-oxoethyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) piperazine -2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) ethyl] -4- (2-methoxy-l-oxoethyl) piperazine-2 -acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-i1] -N- [(4-ethoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] - A - (2-methoxy-1-oxoethyl) piperazin-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazin-2 -acculent; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazin-2- acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (2-methoxy-1-oxoethyl) ) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-y1] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (2-methoxy-1-oxoethyl) ) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-methoxy-1) -oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-methoxy-l- oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-methoxy) -1-oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- (2-methoxy-l-oxoethyl) piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy-1) -oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy-l- oxoethyl) piperazin-2-acetamide; 1- [2- (IH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy) -1-oxoethyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-methoxy-1-oxoethyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (2-methoxy-1) -oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (2-methoxy-l- oxoethyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2-methoxy-1-oxoethyl) piperazine-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyridin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2-methyl-1 -oxoethyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- (2-methoxy-1-oxoethyl) pipera zin- 2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (2-methoxy-1-oxoethyl) pipera zin -2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyridin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (2-methyl-oxy) -1-oxoethyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(indal-5-yl) methyl] -4- (2-methoxy-1-oxoethyl) pipera zin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (tetrahydro-3-furanyl) ) pipera zin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3, -dimethoxy phenyl) propyl] -4- (tetrahydro-3-furanoyl) pipera zin-2-acetamide; 1- [2- (1H-imide zol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(4-ethoxyphenyl) ethyl] -4- (tetrahydro-3-furanyl) piperazine-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methyl-enyl) -ethyl] -A- (tetrahydro-3-furanoyl) -piperazin-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(4-methylphenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2- acetamide; l- [2- (1H-imidazol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2- acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -A- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(4-chlorophenyl) methyl] - (4-tetrahydro-3-furanoyl) piperaz in-2 -acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-chlorofenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (tetrahydro-3-furanoyl) pipera zin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4 -i 1] -N- [(4-methoxy-3-chlorophenyl) ethyl] -4- (tetrahydro-3-furanoyl) ) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] -4- (tetrahydro-3-furanoyl) pipera zin- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (tetrahydro-3-furanoyl) ) piperazin-2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (tetrahydro-3-furanoyl) ) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-di methylphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazine- 2-acetamide; 1- [2- (1 H-imidazol-1-yl) pyrimidin-4-yl] -N- [(pyridin-3-yl) methyl] -4- (tetrahydro-3-furanoyl) piper a zin-2 -carboxamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (tetrahydro-3) -f uranoyl) pipera zin-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (tetrahydro-3-furanoyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxy phenyl) methyl] -4- (tetrahydro-3-furanoyl) pipera zin-2 -acetamide; l- [6-chloro-2- (lH-imide zol-l-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; l- [2- (1H-imidazol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4-tetrahydro-3-furanoyl) piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-difluorophenyl) ethyl] -4- (tetrahydro-3-furanoyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) piperazin-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) methyl] -4- (tetrahydro-3-furanoyl) pipera zin-2-acetamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (2-carboxymethoxy-1-oxoethyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) butyl] -4- (2-carboxymethoxy-1 - oxoethyl) piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) -pyridin-4-y1] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (2-carboxymethoxy-1) -oxoethyl) piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- (2-carboxymethoxy-l- oxoethyl) piperazin-2-acet amide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benz odi-oxol-5-yl) methyl] -4- (2-carboxymethyl) -1 -oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) ethyl] -A- (2-carboxymethoxy-l-oxoethyl) piperazine -2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2-carboxymethyl) -1-oxoethyl) piperazin-2-acetamide; 1- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -A- (2 -carboximet oxy- 1-oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (2-carboxymethoxy-1-oxoethyl) piperazine- 2-acetamide; l- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazine- 2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,4-dimethoxy phenyl) methyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazin-2- carboxamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,6-dimethoxyphenyl) methyl] -4- (2-carboxymethoxy-1-oxoethyl) ) piperazin-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2,6-dimethoxyphenyl) methyl] -4- (2-carboxymethoxy-l-oxoethyl) piperazine-2-carboxamide; l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- (2-phenoxy-1-oxoethyl) ) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) propyl] -4- (2-phenoxy-1-oxoethyl) piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -A- (2-phenoxy-1-l- oxoethyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (2-phenoxy-l) -oxoethyl) piperazin-2-acetamide; 1- [2- (lH-imi da zol-l-yl) -6-trif luoromet i Ipyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] - A - (2-phenoxy-1) -oxoethyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(4-methoxy-enyl) -methyl] -4- (2-phenoxy-1-oxoethyl) pipera zi n-2 -acet amide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (2-phenoxy-1-oxoethyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy-phenylethyl) -4- (pyridin-3-ylcarbonyl) piperazin-2- acetamide; 1- [2 (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-di methoxyphenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) propyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) butyl] -A- (pyridin-3-ylcarbonyl) piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(4-methyl phenoxy) methyl] -4- (pyridin-3-ylcarbonyl) pipera zin- 2 -acetamide; 1- [6-Chloro-2- (1H-imidazol-1-yl) -pyridin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazin-2- acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (pyridin-3-ylcarbonyl ) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-me toxy -3-chloro or phenyl) ethyl] -4- (pyro- 3-i Icarboni 1) pipera zin-2-acetamide; 1- [2- (lH-imide zol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(4-me t-oxy-3-chlorofenyl) ethyl] -4- (pyro] - 3 -ylcarbonyl) pipera zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met-il-pyrimidin-4-yl] -N- [(2,5-di-toxy-phenyl) -ethyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (pyridin-3-ylcarbonyl ) piperazin-2-acetamide; 1- [2- (lH-imi da zol-l-il) pi rimidin-4 -yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -A- (pyridin-3-ylca rbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-carboxamide; 1- [2- (lH-imidazol-1-yl) -6-met-il-pyrimidin-4-yl] -N- [(2,5-dimethyl-phenyl) -methyl] -4- (pyridin-3-i-Icarboni 1) pipera zin-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -A- (pyridin-3-ylca rbonyl) pipe razin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (pyridin-3 -i) Icarboni 1) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (pyridin-3-ylca rbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (pyro- 3- ilcarbonyl) piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazin-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine-2 -acetamide; l- [2- (1H-imidazol-1-yl) -6-met i Ipyrimidin-4 -i 1] -N- [(4-methoxyphenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazine-2 -acetamide; 1- [6-Chloro-2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N- [(2-methoxyphenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazin-2 -carboxamide; l- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (pyridin-3 -i lea rbonil) pi pera zin-2 -acet ami da, • l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2-thionyl) ethyl] -4- (pyridin- 3 - ilcarbonyl) piper a zin-2 -carboxamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-difluorophenyl) ethyl] -4- (pyridin-3-ylcarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (pyridin-3-ylcarbonyl) ) pipera zin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- (pyridin-3-ylcarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (2- (4-methoxyphenyl) ) -1-oxoethyl] -piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] piperazine-2-carboxamide; l- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [ (4-methoxy-3-chlorophenyl) methyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] -piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) - 6-methylpyrimidin-4-yl] - N - [(4-methoxy-3-chlorophenyl) methyl] - A - (2- (4-methoxyphenyl) -1-oxoethyl] -piperazine-2-acetarruda; 1- [2 - (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] piperazine-2 -acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3,5-dimethoxyphenyl) ethyl] -4- (2- (4-methoxyphenyl) -1- oxoethyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4 - (2- (4-methoxyphenyl) -1-oxoethyl] piperaz in-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethyl-1-yl) methyl] -4- (2- (4-methoxy-phenyl) ) -1-Oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethyl-yl-enyl) -methyl] -4 - (2- (4-methoxy phenyl) -1-oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N- [(3,4-Dimethylphenyl) ethyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] -piperazin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-trif luorome ti Ipyrimidin-4-yl] - N - [(3-pyridinyl) methyl] -4- (2- (4-methoxyphenyl) -1-oxoethyl] piperazin-2 -carboxamide; l- [ 6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (2- (4-methoxy-enyl) - 1-oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6) -yl) methyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] -pipe-2-acet-amide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2- (4-me toxy phenyl) -1-oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methoxy phenyl) methyl] -4- (2- (4-methoxy phenyl) ) -1-oxoethyl] pipera zin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3-methoxy phenyl) ethyl] -4- (2- (4-methoxy) phenyl) -1-oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -A- (2 - (4-methoxyphenyl) -1-oxoethyl] piperazin-2-acetamide; 1- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1-methylpyrrol-2-yl) ethyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] piperaz in-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl ] -N- [(3,4-dimethoxy phenyl) methyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] pipera zin-2-acetamide; 1- [2- (lH-imide zol-1-yl) -6-trif luorome ti lpi r imidin-4-lyl] -N- [(3,4-di methoxyphenyl) methyl] -4- (2- (4-methoxy phenyl) -1-oxoethyl] piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(2, 5-dimethoxy-f-enyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-carboxamide; l- [6-chloro-2- (lH-imidazol- l-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] pipe ra zin-2 -acet amide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2- (1, 3 -benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2-methyl-phenyl) methyl] -4- (2- ( 1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [6- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ) ethyl] - A - (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acet amide; l- [2- (lH-imidazol-l-yl) pyrimidin-4- il] -N- [(4-chlorofenyl) methyl] - A - (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [6-chloro-2 - (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazine -2-acetamide; l- [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) ethyl] -A- (2- (1, 3 -benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(4 -methoxy-3-chlorophenyl) ethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazine-2-acetamide; 1- [2- (lH-imidazol-1-yl) ) -6- (Methylethyl) pyrimidin-4-yl] -N- [(3,5-dimethoxy) l) ethyl] -4- (2- (1,3-benzodioxol-5 -i 1) -1-oxoethyl] pipe razin-2-carboxamide; l- [2- (lH-imide zol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2- (1 , 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (2- (1 , 3-benzodioxol-5-yl) -1-oxoethyl] pipe ra zin-2 -acet amide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) ethyl] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2 -acet amide; 1- [6- (lH-imidazole-1 -yl) pyrimidin-4-yl] - N - [(3, 4-dimethylphenyl) ethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -A- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan- 6-yl) ethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [2- (lH-imide zol-1-yl) - 6 -methylpiyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazine-2-acetamide; - [6-chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- [2- (1,3-benzod) ioxol-5-yl) -1-oxoethyl] pipe razin-2 -acet amide; 1- [2- (1 H-imidazol-1-yl) -6-trif luoromet i Ipyrimidin-4-yl] -N- [(3-methyl-phenyl) ethyl] -4- (2- (1, 3 -benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (2- (1,3-benzodioxol-5) -yl) -1-oxoethyl] piperazin-2 -acetic acid; 1- [2- (lH-imide zol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2- thienyl) ethyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2 -acet amide; 1- [2- (lH-imidazol-1-yl) -6- methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] pipera zin-2 - acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-di-methoxyphenyl) methyl] -4- (2- ( 1,3-benzodioxol-5-yl) -1-oxoethyl] piper to zin-2 -acet amide; 1- [2- (lH-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piper to zin-2 -acetamide; l- [2- (lH-imide zol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(2-indanyl) methyl] -4- (2- (1,3-benzodioxol-5-yl) -1-oxoethyl] piperazin-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- (2- (1, 3-benzodioxol-5-yl) -1-oxoethyl] pipera zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- (2- (1,3-benzodioxol-5 -yl) -1 -oxoethyl] piperazin-2 -carboxamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (methylsulfonyl) piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4- (methylsulfonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy-3-chlorophenyl) methyl] -4- (methyl sulphyl) piperazine-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (methylsulfonyl) piperazine-2 -acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -A - (methylsulfonyl) piperazine-2-acetarruda; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-6-yl) methyl] -4- (methylsulfonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-6-yl) ethyl] -4- (methylsulfonyl) piperazin-2- acetarruda; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-6-yl) ethyl] -4- (methylsulfonyl) piperazine-2 -acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (methylsulfonyl) piperazine-2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazin-2 -acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazin-2 acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methylsulfonyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (methylsulfonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (methylsulfonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (methylsulfonyl) piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (methylsul fonyl) piperazin-2 -acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (methylsulfoyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (octylsulfonyl) piperazin-2-acetamide; 1- [6-Chloro-2- (lH-imidazol-1-) l) pyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] -4- (octyl sul phonyl) piperazine -2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) ethyl] -4- (octyl sulphonyl) piperazin- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (octylsulfonyl) piperazine -2-acetamide; l- [2- (lH-imidazol-1-yl) -5-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (octylsulfonyl) piperazine-2- acetamide; 1- [2- (1H-imidazol-1-yl) oyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (octylsulfonyl) piperazine-2-acetarruda; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] -4- (octylsulfonyl) piperazin-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (octylsulfonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methyl-pyrimidin-1-yl] - N - [(4-methoxyphenyl) methyl] -4- (octylsulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) ethyl] -4- (octylsulfonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl] -4- (octylsulfonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxy phenyl) ethyl] -4- (dimethylaminosul fonyl) piperazin-2 acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethylpyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) ethyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- (dimethylaminosulfonyl) piperazin-2 acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (dimethylamine sulfonyl) piperazine-2 -acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazine -2-acetamide; l- [2- (IH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazin-2 acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) ethyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-? M? Dazol-1-? L) p? Pm? Dm-4-? L] -N- [(1,4-benzod? Oxan-6-? ) met? l] -4- (d? met am? sulfon? l) p? peraz? n-2-acetanuda; l- [2- (lH-? m? dazol-l-? l) -6-met? lp? r? m? dm-4-? l] -N- [(1,4-benzod? oxan-6 -? l) met? l] -4- (dimethyl aminosulfon? l) p? peraz? n-2-acetamide; l- [2- (lH-? m? dazol-1-? l) -6- (methylethyl) p? pm? dm-4-? l] -N- [(1,4-benzod? oxan-6- ?) methyl] -4- (dimethylaminosulfonyl) piperaz-2-carboxamide; l- [2- (lH-? m? dazol-l-? l) p? pm? d? n-4-? l] -N- [(1,4-benzod? oxan-6-? l) til] -4- (dimethylamino its Ifonil) p? perazm-2-acetamide; l- [6-chloro-2- (lH-? m? dazole -? -? l) p? pm? d? n-4-? l] -N- [(1,4-benzod? oxan-6- ?) ethyl] -4- (dime ti lamí nosul fon íl) p? peraz? n-2-acetamida; 1- [6-chloro-2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? L] -N- [(4-methoxyphenyl) methyl] -4- ( dimethylammosulfonyl) p? peraz? n-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? Dm-4-? L] -N- [(4-methox? Phen? L) meth? ] -A- (dimethylar? Nosulfon? L) p? Peraz? N-2-acetamide; 1- [6-chloro-2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? L] -N- [(4-methoxyphenyl) methyl] -4- ( dimethylaminosulfonyl) pipera z? n-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] -4- (dimethylaminosulfonyl) piperazine- 2-carboxamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(2,3-dimethoxyphenyl) methyl] -4- (dimethylaminosul fonyl) pipera zin-2- acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (dimethylaminosulfonyl) pipera zin-2 acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4- (dimethylaminosulfonyl) piperazin- 2 -acetamide; l- [2- (1H-Imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,5-di methoxyphenyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-adamantyl) methyl] -4- (dimethylaminosulfonyl) piperazine-2-carboxamide; 1- [6- (1H-imidazol-1-yl) pyrimin-din-4-yl] -N- [(2,3-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -A- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) ethyl] -A- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) propyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-di e-toxi phenyl) butyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxy-phenyl) -methyl] -4- (propylaminocarbonyl) piperazin- 2 - acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acet amide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methylphenoxy) ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -ι-1-pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- tr if luoromet i Ipyrimidin-4-yl] -N- [(4-methyl phenoxy) ethyl] -4- (propylaminocarbonyl) piper a zin- 2 -carboxamide; l- [6-Chloro-2- (1H-imidazol-l-ii) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (propylammocarbonyl) piperazin-2 -acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (propylaminocarbonyl) pipera zin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) ethyl] -4- (propylaminocarbonyl) piperazin-2-acet amide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-chlorophenyl) ethyl] -4- (propylaminocainyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-1-l) -6-methylpyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] -4- (propylaminocarbonyl) piperazine-2- acetamide; 1- [2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -N - [(3-chloro-4-methoxy phenyl) methyl] -4- (propylaminocarbonyl) -piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) - '- methylpyrimidin-4-yl] - N - [(3-chloro-4-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (propylaminocarbonyl) piperazin-2- acetamide; 1- [(2- (1H-imi daz ol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] - A - ( propylaminocarbonyl) piperazin-2-c-atamide; l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] ] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- (propy p -minocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5- il) ethyl] -4- (propylaminocarbonyl) piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethylphenyl) ) methyl] -4- (propylaminocarbonyl) piperazin-2 -acetamide; l- [2- (lH-imidazol-li]) t) irimidin-4-yl] -N- [(1,4-benzodioxan-6-) il) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminocarbonyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (prop? Lam? nocarbonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminoca rbonyl) piperazin- 2-acetamide; l- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (propylaminocarbonyl) piperazine -2-acetamide; l- [2- (lH-imidazol-1-? l) -o-met? lpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; l- [2- (lH-? midazole-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (propylaminocarbonyl) piperazine-2 -acetamide; l- [2- (lH-imidazol-1-? l) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (propylaminocarbonyl) pipera zin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl-4- (propylamino rbonyl) piperazin-2 -acetamide; 1- [6-chloro-2- (lH-imi a zol-1 -i 1) pyr imidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (propylamino-oonyl) -piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-methoxyphenyl) ethyl] -4- (propylaminod bonyl) piperazine-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (propylaminecarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(2-methoxyphenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidaz-l-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-thienyl) ethyl] -4- [propylaminocarbonyl) piperazine-2-carboxamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3,4-di fluorophenyl) ethyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazc-i-yl) pyrimidin-4-yl-N- [(1,4-benzodioxan-2-yl) methyl] -4- (propylaminocarbonyl) piperazin-2- acetamide; l- [2- (lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] -4- (propylaminocarbonyl) piperazine-2 -acetamide; 1- [2- (1 H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] -4-propylaminocarbonyl) pipera zin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,5-di methoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] -4-propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [3,4-dimethoxyphenyl) methyl] -4- (propy'-aminocarbonyl) piperazin-2- acetamide; l- [2- (lH-imide zol-l-yl) -6-methylpyrimidin-4-yl] -N- [3,4-dimethoxyphenyl) methyl] -4- (propylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? L] -N- [(3,5-dimethoxyphenyl) methyl] -4 - (propii or incarcarbonyl) peratin-2-acetamide; l- [2- (lH-? m? dazol-l-? l) p? r? m? dm-4-? l] -N- [(3,5-d? methox? phen? l) met? l] -4- (propylaminocarbonyl) p? peraz? n-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) -6-tr? F luoromet? Lp? Pm? D? N-4-11] -N- (cyclopropyl) -4- (propi. Auiinocarbonyl) p? peraz? n-2-acetamide; l- [2- (lH-? m? dazol-l-? l) p? r? m? d? n-4-? l] -N- (2-? ndan? l) -4- (propylaminocarbonyl) piperazine z-2-acet amide; l- [6-chloro-2- (lH-? m? dazol-1-? l) p? r? m? d? n-4-? l] -N- [(5-indanyl) methyl] -4 - (propylaminocarbonyl) pipe razm- 2 -acet amide; l- [2- (lH-? m? dazol-1-? l) - et? lp? pm? d? n-4-? l] -N- [(3,4-d? methox? phen? l ) et? l] -4- (cyclohexylammocarbonyl) p? perazm-2-acetamide; 1- [6-chloro-2- (lH-imidaz-l-yl) p? R? M? Dm-4-? L] -N- [(4-ethoxy? Phen? L) meth?] -4- (c? clohex lam? nocarbon? l) p? perazm-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? Dm-4-? L] -N- [(4-ethoxy? Phen? L) met ? l] -4- (cyclohexylaminocarbonyl) piperaz? n-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? L] -N- [(4-ethoxy? Phen? L) met? L] -4 - (c? clohex? lam? nocarbon? l) p? peraz? n-2-acetamida; 1- [2- (1H-imidazol-1-yl) -6-met ilpyrimidin-4-yl] -N- [(4-methyl-phenoxy) ethyl] -4- (cyclohexylaminocarbonyl) piperazin-2- acetamide; l- [6-Chloro-2- (lH-imiaa zol-1-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazin-2-acetamide; 1- [ß-chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(4-chloro-phenyl) -ethyl] -4- (cyclohexyl ami-noca-rbonyl) piperazin-2 -acetamide; 1- [2- (1H-imidazol-1?) Oir imidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] -4- (cyclohexyl) ^ m -carbonyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] -4- (cyclohex and laminocarbonyl) pipera zin -2-acetamide; l- [2- (lH-imidazol-1-l) -6-methylpyrimidin-4-yl] -N- [(3-cl-4-methyl-4-methoxy-phenyl) ethyl] -4- (cyclohexylaminocarbonyl) pipera z in-2-carboxamide; 1- [2- (1H-imidazol-1 [beta]) pyr imidin-4-yl] -N - [(3-chloro-4-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- (cyclohexy and aminecabonal) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2 -acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxo-1-5-yl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2 -acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (cyanohexylaminocarbonyl) piperazine-2- acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (cycloh << <; ... laminocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-ii) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] - A - (cyclohexylaminocarbonyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met-1-pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- (cyanohexylaminocarbonyl) piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1? I) -6-methylpyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- (cyclohexyllaminocarbonyl) piperazin- 2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-chloro-2- (1H-imi-zol-1-yl) -pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; 1- [6-Chloro-2- (lH-imide zol-1-yl) pyrimidin-4-yl] -N- [(2-methoxyphenyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazin-2- acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-difluorophenyl) methyl] -4- (cyclohexylaminocarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(2,5-dimethoxyphenyl) methyl] -4- (cyclohexalacarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1? L) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) metii _ -4- (cyclohexylaminocarbonyl) piperazin-2- acetamide; l- [6-Chloro-2- (lH-imidazo-^ -yl) pyrimidin-4-yl] -N- [(2,5-dimethoxy phenyl) methyl] -4- (cyclohex? laminocarbonyl) piperazine-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) methyl-4 - (cycloalkylaminocarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- (2-indanyl) -A- (cyclohexylaminoca bonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-imiaa zol-1-yl) pyrimidin-4-yl] - N - [(4-ethoxyphenyl) methyl] -4- (phenylsuifoniiaminocarbonyl) piperazin-2-acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (phenylsulfonylaminocarbonyl) piperazine- 2-acetamide; l- [5-Chloro-2 (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (phenylsul phonylaminocarbonyl) piperazine-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (phenylsulfonylaminocarbonyl) piperazine-2 -acetamide; 1- [2- (1 H -imidazol-1-yl) -6-trifluoromethyl-4-yl] -N - [(2,3-di-me-to-phenyl) -methyl] -4- (phenylaminocarbonyl) piperazine-2 - to j-ooxamide; l- [2- (lH-imidazol-1-? l) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxy phenyl) ethyl] -4- (phenylaminocarbonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) propyl] -4 - (f ~ m laminocarbonyl) piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (phen-laminocarbonyl-piperazine-2-acetamide; - [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(4-ethoxyphenyl) methyl] -4- (phenylamino-r onyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; 1- [ 6-Chloro-2- (lH-imiaa zol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (phenylalaninecarbonyl) piperazine-2-acetarruda; 1- [2- (lH-imidazol-1-yl) -methyl-pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1? 1) -6-methylpyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- (lH-im? Dazol-1-yl) pyrimidin-4-yl-N- [(4-chlorophenyl) methyl] -4- (phenylammoxyl) piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(4-chlorophenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-chlorophenyl) ethyl] -4- (phenylaminocarbonyl) piperazine-2-carboxamide; l- [6-Chloro-2- (lH-imiaazol o-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- (phenylaminocarbonyl) piperazin-2- acetamide; l- [2- (lH-imidazol-1-yl) -6-tnfluoromethyl-4-yl] -N- [(3-chloro-4-methoxy-phenyl-1-yl] -4- (phenylaminocarbonyl) piperazine] -2- j.boxamide; l- [6-Chloro-2- (lH-im? dazol-1-yl) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenyl) ethyl] -4- (phenylaminocarbonyl) piperazine-2- acetamide; 1- [6-chloro-2- (lH-im? Dazol-1-? L) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- (remlam? nocarbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-i-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (phen? lam-nocarbonyl) piperazine-2 -acetamide; 1- [2- (1H-imidazol-1-U) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (phenylaminocarbonyl) piperazin-2 acetamide; l- [6-Chloro-2- (lH-im? dazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (in Ummocarbonyl) piperazin-2-acetamide; l- [6- (lH-? midazole-l-? l) pyr_midin-4-yl] -N- [(1, 4-benzodioxan-6-yl) methyl] -4- (phen? lam? nocarbonyl) piperazine -2-acetamide; 1- [2- (1H-imidazol-1? I) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- (phen? Xm? Nocarbonyl) piperazine -2-acetamide; 1- [6-chloro- 2- (lH-? M? Dazol-1-? L) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- (phenyl anu nca rbonyl) pipera zin-2-acetamide; l- [6-chloro-2- (lH-? m? Jazol-l-? l) pyr imidin-4-yl] -N- [(3-methoxifenyl) methyl] -4- (f -nylcarunoyl) pipera zin -2 -acet amide; 1- [2- (1H-imidazol-1-U) -6 -methylpiyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (phenylaponcarbonX) piperaz in-2 -acet amide; l- [2- (lH-imidazole-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) ethyl] -4- (f enylmethyl) pipera razin-2 -acet amide; 1- [2- (1H-imidazol-1-? U p? Pmidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (phenylaminocarbonyl) piperazine-2-acetamide; l- [2 - (lH-imidazol-1-yl) pyrimidin-4-yl-N- [(3-thienyl) ethyl] -4- (phenylaminocarlronyl) p? perazin-2-acetamide; 1- [6-chloro-2- ( lH-im? adZ? l-1-? l) pyrimidin-4-yl] - N - [(3, 4-difluorophenyl) methyl] -4- (fe ni larr nocarbonyl) pipera zin-2-acetamide; - 33 l- [6-chloro-2- (lH-? M? Oazol-1-? L) p? R? M? Din-4-? L] -N- [(2,5-dimethoxyphenyl) me useful ] -4- (phenylaminocarbonyl) p? Perazin-2-acetamide; 1- [6-chloro-2- (lH-? RPi.dazolo-l-? L) p? R? M? D? N-4-? L] -N- [(3,4-dimethoxy phenyl) metu] -4- (f -arylaminocarbonyl) piperazin-2-acetamide; l- [2- (1H-? m? dazol-1-? l) -6- (methylethyl) p? rim? dm-4-yl] -N- [(3, -dime-phenyl) -methyl] -4 - (f eni lamí noca rbonil) piperazin-2-acetamide; l- [6- (lH-? md? dazol-l-? l) p? pm? din-4-yl] -N- [(cyclopropyl) met? l] -4- (fen? lam? nocarbon) ?) prazeran-2-carboxamide; l- [6-chloro-2- (lH-? m? azole-l-? l) p? pm? din-4-? l] -N- [(5-indanyl) methyl] -4- (f enylaminoocc rbonyl) p iper az? n-2-acet amide; l- [6- (lH-? m? dazol -.-? l) p? pm? d? n-4-? l] -N- [(2,3-dimethoxyphenyl) ethyl] -4- [(4 -met? if enyl) ai noca rbonyl] piper to zm-2-carboxamide; 1- [2- (lH-? M? Dazol-1-a.) -6- (metil til) p? Pm? Din-4-? L] -N- [(2, 3-d? Methox? phenol) ethyl] -4 - [(4-methoxy-enyl) -ammocarbonyl] pip ^ razin-2 -carboxamide; 1- [6-chloro-2- (lH-? M? Aazol-1-? L) p? R? M? D? N-4-? L] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-meA.ox: phen? L) am ocarbonyl] pipera zin-2-acetam? Da; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- ['4-methoxy-phenol) aminocarbonyl ] piperazin-2-acetamide; 1- [2- (lH-? Midazoi-1-? L) p? R? Midin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- [(4-methoxy-xenyl) aminocarbonyl] piperazine- 2-acetamide; l- [6-Chloro-2- (lH-yl-yl-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenoxy) ethyl] -4- [(4-methoxyphenyl) aminocarbonyl] ] piperazin-2-acetamide; l- [2- (lH-imidazol-lX) -6-tr? fluoromethy1-pyrimidin-4-yl] - N - [(4-methylphenyl) methyl] -A - [(4-methoxyphenyl) aminocarbonyl] p? perazin-2 -acetamide; 1- [2- (lH-imidazol-1-? L) p? R? Midin-4-yl] -N- [(4-chlorophenyl) met? L] -4- [(4-met? / Renyl) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-l pi r? m? d? n-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4- [(4-met ??? ifenyl) aminocarbonyl] piperazine-2-carboxamide; 1- [2- (lH-imidazol-1-? l) ir? m? d? n-4-yl] -N- [(3-chloro-4- methoxyphenyl) methyl] -4- [(4-methoxy-phenyl) aminocarbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-. 1) -6-me ti Ipyrimidin-4-yl] - N- [(3-chloro-4-methox? Phen?) Methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] p? PA-razin-2-acetamide; l- [6-Chloro-2- (lH-im? dazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) ethyl] -4 - [(4 - methoxyphenyl) aminocarbonyl] pip raz-n-2-acet amide; l- [6-chloro-2- (lH-? m? aazol-1-? lj p? rimidin-4-yl] -N- [(2,5-dimethoxyphenyl) ethyl-4- [(4-metho <? phenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazole -.-? l) p? rimidin-4-yl] -N - [(2,5-dimethoxyphenyl) ethyl] -4 - [(4-met-j? Ifenyl) aminocarbonyl] piperazine-2-carboxamide; l- [2- (lH-imidazole-1-l) p? R? Midin-4-yl] -N - [(1) , 3-benzodioxol-5-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] p? Perazin-2-acetamide; 1- [2- (lH-imidazol-1-y) -6- ( methylethyl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [2-] 6-met? Lpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-l) methyl] -4 - [(4-methoxyphenyl) aminocarbonylpiper? -2 -carboxamide; 1- [6-chloro] -2- (lH-? M? Aazol-1-? L) p? Rimidin-4-yl] -N- [(1,3-benzodioxol-5-l) methyl] - A - [(4-methoxyphenyl) aminocarbonyl] p? pr.razin-2-acetamide; l- [2- (lH-? m? dazoi-l-? l) p? pmidin-4-yl-N- [(l, 3-b) e n z o d i or x o l - 5 -? l) e t i l] -4 - [(4-methoxyphenyl) aminocarbonyl] piperazin-2 -acetamide; - roo - 1- [6-chloro-2- (lH-imidazol-1-? l) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl)] - A - [(4 -methoxyphenyl) aminocarbonyl] pi 'a zin-2 -acetamide; 1- [2- (lH-imidazol-li.) -6-met i Ipyrimidin-4-yl] -N- [(1,3-benzodioxol-5 -? l) ethyl] - A - [(4-methoxy phenyl) aminocarbonyl] piperazin-2-acetamide; 1- [6-chloro-2- (lH-im? c, azol-i-yl) pyrimidine- 4-yl-N- [(3,4-dimethylphenyl) methyl] -4- [(4-metho? Phen?) Aminocarbonyl] piperazine-2-acetamide; l-6- (lH-imidazolU-yl) pyrimidin-4-yl] -N - [(3,4-dimethylphenyl) methyl] -4- [(4-methyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-furyl) methyl] -4- [(4-methoxy-fe il) am- nocarbonyl] piperazine- 2-acetamide; l- [2- (lH-? midazole -_-? l) p? r? midin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4 - [(4 -methoxyphenyl) aminocarbonyl] pip -ua zin-2 -acet amide; l- [6-chloro-2- (lH-imia ^ zol-l-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) meti 1] - A - [( 4-methoxyphenyl) aminocarbonyl] -foot-2-acetamide; 1- [2- (1H-imidazol-1-.) -6-wnetylethyl) pyrimidin-4-yl] -N- [(1,4-benzodioxa-6-yl) methyl] - A - (4 - methoxyphenyl) aminocarbonyl 1 pipara zin-2-cet amide; - X6-l- [2- (lH-imidazol-1-yl) -6-met? Ipyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl] ethyl] - A - [ (4-methoxyphenyl) aminocarbonyl] pi A- -1 .. in -2 -acetamide; l- [2- (lH-imidazole -: -? L) p? Rimidin-4-yl] -N- [(l, 4-benzodioxan-6-yl) ethyl] - A - [(4-methoxyphenyl) aminocarboni jp? Perazin-2-acetamide; l- [6-chloro-2- (lH-im? • zol-1-? ) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4 - [(4-methoxyphenyl) aminocarbonyl] p? p-razine-2-carboxamide; l- [2 - (lH-imidazol-1-) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(4-methyl X emi) ami noca rbonyl] pipera zin-2 -acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- [(4-methoxy-phenyl) aminocarbonyl] piperazine- 2-acetamide: 1- [2- (1H-imidazol-1- ^ X -6-methy1-pyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- [(4-methyl Xenyl) aminocarbonyl] piperazin-2-acetamide; l- [6-chloro-2- (lH-? m_Jazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) eti l] -4- [(4-methox. phenyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) ethyl] -4- [(4-meth? phenyl) aminocarbonyl] piperazine-2-acetamide; - r57 - 1- [2- (lH-? midazol-1-) -6- (methylethyl) pyrimidin-4-yl] - N - [(1,4-benzodioxa - - 2 -? l) ethyl] - 4 - [(4-methoxyphenyl) aminocarbonyl] piperazin-2-acetamide; l- [5-chloro-2- (lH-? m? dazo] -l-yl) pyrimidin-4-yl] -N- [(2,3-dimethoxyphenyl) methyl] -4- [(4-meth roxyphenyl) aminocarbonyl] piperazine-2-acetamide; l- [6-chloro-2- (lH-? mi '=. zol-1-? l) pyrimidin-4-yl-N- [(2,5-dimethoxyphenyl) methyl] -4- [(4-methox fen? l) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-L) -6-met? l-pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methyl-oxyphenyl) aminocarbonyl] ] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imi, zol-1-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methyl-oxyphenyl) aminocarbonyl] piperazine-2-acetamide; 1- [6-chloro-2- (lH-i: dazol-1-yl) pyrimidin-4-yl] -N- [(cyclopropyl) methyl] -4- [(4-me roxyphenyl) aminocarbonyl] piperazine-2 -acetamide; 1- [6-chloro-2- (lH-? _ Azol-1-? L) pyrimidin-4-yl] -N- (2-indanyl) -4- [(4-methoxy phen i 1) ar mocarbonyl] pipe ra zin-2 -acet amide; 1- [2- (1H-imidazol-1-U) -6-methyl-1-pyrimidin-4-yl] -N- [(5-indanyl) methyl] -4- [(4-methox-enyl) aminocarbonyl] ] piperazin-2-acetamide; -: tí - l- [2- (lH-imidazol-1 i) -o-methylpyrimidin-4-yl] -N - [(3,4-dimethoxyphenylethyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl ] piperazin-2-acetarruda; l- [6-chloro-2- (lH-im ?: > -.zol-l-yl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ^ or ^ l] - A - [(3,4-dichlorophenyl) aminocarbonyl] p-cerazin-2-acetamide; l- [6-chloro-2- (lH-imi- ~ yol-l-yl) pyrimidin-4 -yl] -N- [(3,4-dimethoxyphenylutyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] picerazine -acetamide; 1- [2- (lH-imidazole-1- •.) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-ethoxyphene)) i]] - 4 - [(3,4-dichlorophenyl) aminocarbonyl] pi r erazin-2 -acetamide; 1- [2- (lH -imidazole-1-U) -6-methy1-pyrimidin-1-yl] -N- [(4-ethoxyphenyl) methyl] -4- [(3,4-dio-orphe-1-aminocarbonyl] piperazine-2-acetamide; 6-chloro-2- (lH-im., Ozol-i-yl) pyrimidin-4-yl] -N- [(4-methylphenoxy) ethyl] -4- [(3,4-dicl-phenyl) aminocarbonyl] piperazine -2-acetamide; 1- [2- (lH-imi dazol-1- i) -6-mer and Ipyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(3, -di:. phenyl) aminocarbonyl] piperazine-2-acetamide; 1- [6-chloro-2- (lH-im; - a zol-1-yl) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- [(3, 4-di or orofe il) aminocarbonyl] piperazin-2-acetamide; - 39 - 1- [2- (lH-imidazol-1-yl-pyrimidin-4-yl] - N - [(4-chlorophenyl) methyl] -4- [(3,4-d? R U? aminocarbonyl] piperazine-2-acetamide; l- [6-chloro-2- (lH-? m-azol-l-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4 - [(3, 4-d? C.rrofeml) aminocarbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-lU) pyrimidin-4-yl] -N- [(3-chloro-4 -me toxy phenyl) methyl] -4 - [(3,4-d? orofen-1 '' aminocarbonyl] piperazine-2-acetamide; l- [6-chloro-2- (lH-im? .- zol-1-? l) pyrimidin-4-yl] -N- [(2,5-dimethoxyphenylmethyl] -4 - [(3, 4-di chlorofenyl) aminocarbonyl] pi e ra zin -2 -acet amide; l- [6-chloro-2- (lH-imi -.zol-1-? L) pyrimidin-4-yl] -N- [ (1,3-benzodioxol-5 -:) meti 1] - 4 - [(3, A-dichlorophenyl) aminocarbonyl] p: ee? Az? N-2 -acetamide; l- [2- (lH-imidazol-1 -A) -6-methylpyrimidin-4-yl-N- [(1,3-benzodioxol-5-y) methyl]] - 4 - [(3,4-di chlorofenyl) aminocarbonyl] p:. 1-acetamide; l- [2- (lH-imidazoI- ^ 1) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] - A - [(3 , A-dichlorophenyl) aminocarbonyl] p: erazin-2-acetamide; l- [6-chloro-2- (lH-i: zol-1-? L) pyrimidin-4-yl] -N- [(1,3 -benzodioxol-5-l) etl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] p: reason -2 -acetamide; - 60 - l- [2- (lH-imidazol-1- '.7 -6-methylpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-. 1) ethyl] -4 - [( 3,4-dichlorophenyl) aminocarbonyl] p.? Ra zin -2 -acet amide; l- [6-chloro-2- (lH-im? ... zol-i-yl) pyrimidin-4-yl-N- [(3,4-Dimethylphenyl) methyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] pr e-n-2 -acetamide; l- [2- (lH-imidazoy-yl) pyrimidine-4- il] -N- [(1,4-benzodioxan-6-yl) me "il] -4 - [(3,4-dichlorophenyl) aminocarbonyl]: - e-reason in -2 -acetamide; 1- [6- chloro-2- (lH-? m?:, azol-l-yl) pyrimidin-4-yl] - N - [(1,4-benzodioxan-6-yl) methyl] - A - [(3, 4 -dichlorophenyl) aminoca bonyl] p. e raz. -2 -acetamide; 1- [2- (lH-imidazol-1.) -6-met? lpyrimidin-4-yl] -N- [(1,4 -benzodioxan-6-1) ethyl] -4 - [(3, A-dichlorophenyl) aminocarbonyl] p '. -razir.-2-acetamide; 1- [2- (lH-imidazof-i-yl) pyrimidine- 4-yl] -N- [(4-me toxi phenyl) methyl] -4- [(3, 4-di-orofenii) aminocar bonil] pipera z in-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(3,4-di-Drophenyl) aminocarbonyl] piperazine -2-acetamide; 1- [6-chloro-2- (lH-i: .azol- -11) pyrimidin-4-yl] -N- [(4-methyloxy phenyl) methyl] -4- [(3,4-di-Drofenil aminocarbonyl] piperazin-2-acetamide; - 61 - 1- [2- (IH-imidazo. - _ - i 1, pyrimidin-4-yl] - N - [(3-methoxyphenyl) methyl] -4 - [(3,4-d-orophenyl) aminocarbonyl ] piperazin-2-acetamide; 1- [2- (1H-im? dazol- -.) -6 -methylpyrimidin-4-yl] -N- [(3-methoxyphenyl) methyl] -4- [( 3, Ad-orophenyl) aminocarbonyl] piperazine-2-acetamide; 1- [6-chloro-2- (lH-i-1, 1- 1) pyrimidin-4-yl] -N- [(-me toxy phenyl) ethyl] -4 - [(3,4-d? _. Propyl) aminocarbonyl] piperazine-2-acetamide; l- [2- (lH-im? Dazol-1- 1-6- (methylethyl) pyrimidin-4-yl) ] -N- [(2, 5-dimethoxy? Pheyl) methyl] -4- (3,4-dichlorofenyl) aminocarbonyl _ -raz? N-2-acetamide; l- [2- (lH-im? dazol-1-, - 6-met ilpyrimidin-4-yl] - N - [(2,5-dimethoxyphenylmethyl] -4 - [(3,4-dichlorophenyl) aminocarbonyl] p. razm-2-acetamide; l- [ 6-chloro-2- (lH-ip rol-1.) P? Rim? Din-4-yl] -N- [(2,5-dimethoxyphenylethyl) -4 - [(3, A -dichlorophenyl) aminocarbonyl] p : erazm-2-acetamide; 1- [2- (lH-im? dazol-1-, -6-met? lpyrimidin-4- il] -N- [(3,4-d i m e t o x i f e n? l n e t • 1] - 4 - [(3,4-di chloro phenyl) ami noca rbonyl _, e raz -2 -acetamide; l- [2- (lH-imidazole-) p? rimidin-4-yl] -N- [(3,4-dimethoxyphenylmethyl) -4 - [(3, A-dichlorofenyl) aminocarbonyl] p erazi '- ". -acetamide; - -62- l- [2- (lH-imidazol-1-6- et? Lpyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] - A - (met-arbonyl) p Perazine-2-acetamide: 1- [6-chloro-2- (lH-i-azol-1- (1-yl) pyrimidin-4-yl] -N- [(4-ethoxyphenyl) methyl] -4- (methoxycycloon) 'piperazin-2-acetamide; l- [6-chloro-2- (IH-im "zol- ^ -1) pyrimidin-4-yl] -N- [(4-methylphenyl) methyl] -4- (methoxy) oonyl i piperazin-2-acetamide; 1- [6-chloro-2- (lH-im., azole-1-? l) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- (methoxy oonyl) piperazin-2-acetamide; 1- [6-chloro-2- (lH-ir a zol-i-U) pyrimidin-4-yl-N- [(3-chloro-4-methoxy phenyl) met 1I] - - (methoxycarbonyl) piperazin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl-N- [(3-chloro-4-methox-phenyl)] ethyl- - (meth i oxycarbonyl) piperazin-2-acetamide; l- [6-chloro-2- (lH-? mL ol-1-? l) pyrimidin-4-yl] -N- [(1, 3- benzodioxol-5-yl) methyl] -4- (me <? caroonil) piperazin-2-acetamide; l- [6-chloro-2- (lH-irr- -.zol-l-yl) pyrimidine-4- il] -N [(1,3-benzodioxol-5-yl) ethyl] -A - (only - Icarronyl) piperazin-2-acetamide; 1- [2- (1H-imidazol- ± - 6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl-4- (methylne) piperazine-2-acetamide; l- [2- (lH-imidazo-yl) p? rimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- (methacryl) piperazine-2 -acetamide; l- [6-chloro-2- (lH-in. ^ ol-i-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- (me carbonyl) piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- (methoxycarbonyl) piperazin-2- acetamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -A- (methoxycarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(4-methoxyphenyl) methyl] -4- (methoxycarbonyl) piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl 'pyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (methoxycarbonyl) piperazine-2-acetamide; 1- [ 2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] -4- (methoxycarbonyl) piperazine-2-acetamide; l- [6-chloro- 2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methoxyphenyl) ethyl] -4- (methoxycarbonyl) piperazine-2-acetamide; 1- [6-chloro-2- ( lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-2-yl) methyl] -A- (methoxycarbonyl) piperazine-2-acetamide; l- [2- (lH -imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) methyl] -4- (methoxycarbonyl) piperazin-2-acetamide; 1- [2- ( lH-imidazol-l-yl) -6-met ilpyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) met il] - 4 - (meth i letoxi ca rboni l) pipe ra z in-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- (me ti toxycarbonyl) piperazin-2 -acetamide; l- [2- (1H-imidazol-1-yl) -pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -A- (butoxycarbonyl) piperazine-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl-N - [(1,4-benzodioxan-6-yl) methyl] -4- (butoxycarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (butoxycarbonyl) piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- (butoxycarbonyl) piper a zin-2-acet amide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3, 4-di fluorophenyl) methyl] -4- (butoxycarbonyl) pipera zin-2 -carboxamide; 1- [6-Chloro-2- (1H-imi-zol-1-yl) -pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; 1- [2- (IH-imide zol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-chloro-4-methoxy phenyl) methyl] -4- [(2-methoxyethoxy) carbonyl] ] piperazin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] - A - [(2 - methoxyethoxy) carbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] -4- [(2-methoxyethoxy) carbonyl ] piperazin-2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazin-2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(2-methoxyethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(2-methoxyethoxy) carbonyl ] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) ethyl] -4- [(2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -5-methylpyrimidin-4-yl-N- (1,4-benzodioxan-6-yl) ethyl] -4- (2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxyphenyl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazine-2- acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] - A - [(2-methoxyethoxy) carbonyl] piperazine-2 -acetamide; l- [6-Chloro-2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(3,5-dimethoxyphenyl) methyl] -4- [(2-methoxyethoxy) carbonyl] piperazine- 2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-chlorophenyl) methyl] -4- [(phenylmethoxy) carbonyl-Jpiperazin-U-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1, 3-benzodioxol-5-yl) methyl] -4- [(phenylmethoxy) carbonyl] piperazin-2- acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazin-2- acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,3-benzodioxol-5-yl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(phenylmethoxy) carbonyl] piperazin-2- acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(1, 4-benzodioxan-6-yl) methyl] -4 - [(phenylmethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(phenylmethoxy) carbonyl] piperazine -2-acetamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) methyl] -4- [(phenylmethoxy) ca rboni lpipe raz in-2 -acetamide; 1- [6- (lH-imi da zol-l-yl) pyrimin-din-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- [(phenylmethoxy) carbon il-Piperazin-U- carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) methyl] -4- [(phenylmethoxy) carbonyl] piperazine-2-acetamide; l- [6-Chloro-2- (2H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-methoxy phenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-met i Ipyrimidin-4-l-N- [(4-methoxyphenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazine-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(2-thienyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazine-2-acetamide; l- [6-Chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl-N- [(3,4-dimethoxy phenyl) ethyl] -A- [(phenylmethoxy) carbonyl] piperazine- 2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N - [(3,4-dimethoxyphenyl) ethyl] -4- [(phenylmetoxy) carbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) ethyl] -4- [(phenylmethoxy) carbonyl] piperazine- 2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) methyl] -4- [(1-methylpropoxy) carbonyl] pipera zin -2 -acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [(1, 3-benzodioxol-5-yl) ethyl] -4- [(1-methylpropoxy) carbonyl] pipe in-2-acetamide; 1- [6-chloro-2- (1H-imidazol-1-yl) pir imidin-4-yl] -N- [(4-methoxyphenyl) methyl-4- [(1-methylpropoxy) carbonyl] piperazin-2- acetamide; l- [6-Chloro-2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-chloro-4-methoxyphenyl) methyl] -4 - [(4-methoxy phenoxy) carbonyl ] pipera zin-2 -carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(3, 4, 5-tr ime toxi nyl) useful] - 4 - [ (4-methoxyphenoxy) carbonyl] piperazine-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-trifluoromethyl-4-y1] - N - [(1,4-benzodioxan-6-yl) methyl] -4- [(4-methoxyphenoxy)] carbonyl] piperazine-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(1,4-benzodioxan-6-yl) methyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine- 2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1,4-benzodioxan-6-yl) ethyl] -4- [(4-methoxyphenoxy) carbonyl] ] piperazin-2-acetamide; l- [6- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-methoxyphenyl) methyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(1-methylpyrrol-2-yl) ethyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine -2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] -N- [(2,4-dimethoxyphenyl) methyl] -4 - [(4-methoxyphenoxy) carbonyl] piperazine-2-carboxamide; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [(2,6-dimethoxyphenyl) methyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine- 2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3,4-dimethoxyphenyl) methyl] -4- [(4-methoxyphenoxy) carbonyl] piperazine-2 -carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- [1- (phenylmethyl) piperidin-4-yl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1-cyanocyclohexyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- (2, 2-dimethoxyethyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethyl-1-pyrimidin-4-yl-N-trideeylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(2-hydroxy-4-methylthiobutyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N, N- [bis (2-cyanoethyl)] piperidin-2-acetamide; 1- [2- (1H-imide zol-1-yl) -6-methyl-1-pyrimidin-4-yl] -N, N- [bis (2-cyanomethyl)] piperidin-2-acetamide; 1- [2- (IH-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(4,4-diethoxybutyl) piperidin-2-acetamide; 1- (4-fluorophenyl) -4- [1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] piperazine; l- [(1, 3-Benzodioxol-5-yl) methyl] -4- [l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] piperazine; 1- (phenylmethyl) -4- [1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -piperidin-2-acetyl] piperazine; 4- [1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] piperazine-1-carboxylic acid ethyl ester, 1- (4-chlorophenyl) -4- [l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] -4-hydroxypiperidine; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(2,3-dihydrobenzofuran-5-yl) methyl) piperidin-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? D? N-4-? L] -N- [(mdan-5-? L) methyl) pipen din-2 -acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? D? N-4-? L] -N- [(cyclohexyl) methyl] p ipe ridm- 2 -acet amide; 1- [2- (lH-? M? Dazol-l-? L) p? Pm? D? N-4-? L] -N- [(1,2,3,4-tetrahydronaf talen-il ) pipe pdm-2 -acet amide; 1- [2- (lH-? M? Dazol-l-? L) p? R? M? D? N-4-? L] -N- [(naf talen- 1-íl) useful) pipe ridm - 2 -early; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M? Dm-4-? L] -N- [(1,3-benzod? Oxol -5-? L) methyl] piper din-2-acet knots; 1- [(2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? Pm? D? N-4-? L] -N- [(4-chlorophen? L) met? l] pipe pdm- 2 -acet amide; 1- [2- (lH-? m? dazol-1-? l) - 6-met? let? lp? pm? d? n-4-? l] -N- (2-et? Lhex? L) pipe ridin- 2 -acet amide, l- [2- (lH-? M? Dazol-l-? L) p? R? M? Dm-4-? ] -N- (2-ethylhexyl) pipe pdm-2 -aceta-borrant; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? Pm? D? N-4- ? l] -N- (2-ethylhexyl) pipe pdm-2 -acetarate; 1- [2- (lH-? m? dazol-1-? l) -6-met? let? lp? pm? d? n-4-? l] -N- [2- (morpholm-4-? l) et? l] p ipe pdm-2-acet amide; 1- [2- (lH-? m? dazol-1-? l) -6-met? lp? r? m? d? n-4-? l] -N- (1-methylhexyl) pipe pdin-2-acet amide; 1- [2- (lH-? m? dazol -1-? L) -6-met? Let? Lp? R? M? Dm-4-? L] -N- (1-met? Lhex? L) pipe ndin-2-acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1-methylhexyl) pipe ridin-2 -acetic acid; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(2-methylphenyl) methyl] piper idin-2-acet amide; 1- [2- (lH-imi da zol-l-il) -6 -me ti le ti Ipyrimidin-4-yl] - N - [(4-methoxy phenyl) methyl] piper idin-2-acet amide; l- [2- (1H-imidazol-1-yl) -6-methy1-imidin-4-yl] -N- [(4-methoxy phenyl) methyl] pyridine-2-acetic acid; 1- [2- (1H-imi da zol-1-yl) -6-met i le ti Ipyrimidin-4-yl] -N- (cyclooctyl) pipe ridin-2-acet amide; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- (1-ethyl-3-hydroxy-1-hydroxyethyl-1-propyl) piper idin-2-acet amide; 1- [2- (1 H-imidazol-1-yl) -6-met-ilet-1-pyrimidin-4-yl] -N- [3- (morpholin-4-yl) propyl] piper idin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (1-meth i 1-3-phenylpropyl) pipe ridin-2 -aceta-free; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1-meth i 1-3-phenylimpropyl) pipe ridin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) -6-methyl-1-pyrimidin-4-y1] -N- (1-methyl-3-phenylpropyl) p ipe ridin-2 -acet ami da; 1- [2- (1H-imidazol-1-yl) -6-meth i le ti Ipyrimidin-4-yl] -N- (1-methylheptyl) pipe ridin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1-methylheptyl) pipe ridin-2 -acet amide; l- [2- (lH-? m? dazol-1-? l) -6-met? lp? r? m? dm-4-? l] -N- (1-methylheptyl) pipe ridm- 2 -acet amide; l- [2- (lH-? m? dazol-l-? l) p? r? m? dm-4-? l] -N- [(3-fluorofen? l) met? l] piper? d? n-2- ace tarruda; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? Dm-4-? L] -N- [(3-fluorofen? L) met? L ] piper din-2 -acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? Pm? D? N-4-? L] -N- [(4-met? Lfen? L ) methyl] pipe ndm- 2 -acetreate; 1- [2- (lH-? M? Dazol-l-? L) p? Pm? D? N-4-? L] -N- (1-phenylethyl) pipe pdm-2 -acetic acid; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? Dm-4-? L] -N-f enylmethylpipe pdm-2 -acet amide; 1- [2- (lH-? Rtudazol-1-? L) -6-met? Let? Lp? Pm? D? N-4-? L] -N- [(3,4-d? Chlorophen? ) met? l] piper í in- 2 -acet knots; l- [2- (lH-? m? dazol-l-? l) p? r? m? d? n-4-? l] -N- (2-phenylethyl) pipe pdm-2-acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? Dm-4-? L] -N- (2-phenylethyl) pipe ndm- 2 -acet amide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M? D? N-4-? L] -N- [3- (p? Rrol ? don-1-? l) propyl] pipe pdm-2-acet amide; 1- [2- (lH-? M? Dazol-1-? L) p? R? M? D? N-4-? L] -N- (1, 5-dimethylhexyl) pipe r? D? N- 2 -acet amide; l- [2- (lH-? m? dazol-1-? l) -6-met? lp? r? m? dm-4-? l] -N- (1,5-dimethylhexyl) p ipe ridin- 2-acet amide, 1- [2- (1H-imidazol-1-yl) -6-met-ilet-1-pyrimidin-4-yl] -N- (1, 5-dimethylhexyl) piper idin-2 -acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl-N- [(2-p-fluorophenyl) methyl] pipe-ridin-2 -acetic acid; l- [2- (lH-imidazol-l-yl) -6-met i Ipyrimidin-4-yl] -N- [(2-f luorofenyl) methyl] pipe ridin-2 -acet mide; 1- [2- (1H-imidazol-1-yl) -6-met i let ilpyr imidin-4-yl] -N- [(3,4-dimethoxy phenyl) methyl] pipe ridin-2 -aceta-r; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3, 4-dimethoxyphenyl) methyl] piper idin-2 -acetic acid; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (2-chloro-phenyl) -ethyl] -pyridin-2 -acetic acid; 1- [2- (1H-imidazol-1-yl) pi r imidin-4-yl] -N- [(f -uran-2-yl) methyl] pipe-ridin-2-acet amide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidi-4-yl] -N- [(furan-2-yl) methyl] p ipe ridin-2 -acet ami da; 1- [2- (1H-imidazol-1-yl) -6-met-ylethylpyrimidin-4-yl] -N- [(furan-2-yl) methyl] piper idin-2 -acet amide; 1- [2- (lH-imi da zol-l-il) -6 -me ti le ti Ipyrimidin-4-yl] - N - [(pyridin-2-yl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(pyridin-2-yl) methyl] pipe-ridin-2 -acertrudate; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(pyridin-2-yl) methyl] pipe ridin-2-a-cet amide; 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- [(3-trifluoromethyl-phenyl) -methyl] -piperidin-2-acetarruda; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N - [(3-trifluoromethylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (2-phenylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-y1] -N- (2-phenylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (2-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -pyrimidin-4-yl-N- [2- (2-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- (2-hydroxy-4-methylthiobutyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (2-hydroxy-4-methylthiobutyl) piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [(2,4-dichlorophenyl) methyl] piperidin-2-ace Lamida; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(3-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(3-methylphenyl) methyl] piperidin-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) - 6-met i let? Lp? R? M? D? N-4-? L] -N- [2- (3-methox F ethyl) ethyl] p ipe pd? n-2 -acet ami a; l- [2- (lH-? m? dazol-l-? l) p? pm? d? n-4-? l] -N- [2- (3-methoxyphenyl) ethyl] pipe pd-2-ace tarruda; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Lp? R? M? Dm-4-? L] -N- [2- (3-methoxyphenyl) ethyl] pipe r? dm-2-acet amide; 1- [2- (lH-? M? Dazol-i-? L) p? R? M? D? N-4-? L] -N- [2- (3-methox? Phen? L) et? l] pyrrolidone-2-carboxamide; 1- [2- (lH-? M? Dazol-1-? L) -6-met? Let? Lp? R? M? D? N-4-? LN- [2- (3, 4-d? methox? phen? l) ethyl] piperidin-2-acetamide; 1- [2- (lH-? M? Dazol-1-? L) p? R? M? Dm-4-? L] -N- [2- (3,4-dimethoxy-enyl) ethyl] p? Pepdm -2-acetam? Da; 1- [2- (IH-ipudazol-lU) -6-met? Lp? Pm? D? N-4-? L] -N- [2- (3, 4-d? Methox? F enyl) ethyl] pipe pdm- 2 -acetart; 1- [2- (lH-? M? Dazol-1-? L) pi rmidmid- 4 -i 1] -N- [2- (3,4-dimethoxyphenyl) ethyl] pyrrolidm-2- carboxam? da; 1- [2- (lH-? M? Dazol-1-U) -6-met? Let? Lp? Pm? D? N-4-? L] -N- (phenylbutyl) p ipe ri din- 2 - ace tñida; 1- [2- (lH-? M? Dazol-1-? L) -p? R? M? D? N-4-? L] -N- (f-enylbutyl) piper? Dm-2-acet amide; 1- [2- (lH-? M? Dazol-1-? L) p? Pm? D? N-4-? L] -N- (1-hydroxymethylpentyl) pipe ridin- -acet amide; 1- [2- (lH-? M? Dazol-1-U) - 6-met? Lp? R? M? D? N-4-? L] -N- (1-hydroxymethylpentyl) piper din- 2 - acet amide; 1- [2- (lH-? M? Dazol-1-U) -6-met? Let? Lp? R? M? D? N-4-? L] -N- [(3, 5-d? methox? f enil) useful] pipe pdin- 2 -ace tarruda; 1- [2- (lH-? M? Dazol -_-? L) p? R? M? D? N-4-? L] -N- [(3,5-dimethoxyphenyl) methyl] pipe ndm- 2 -ace tarruda; l- [2- (lH-? m? dazol-1-? l) -6-met? lp? r? m? d? n-4-? l] -N- [(3,5-dimethoxy-enyl) methyl] pipe pdin- 2 -a cet amide; 1- [2- (lH-? M? Dazol-l-_l) -6-met? Let? Lp? R? M? Dm-4-? L] -N- [2- (4-ethoxy? Fen? l) et? l] pipe ndm- 2 -acetarr; l- [2- (lH-? m? dazol-J-? l) p? r? m? d? n-4-? l] -N- [2- (4-ethoxy? phen? l) et ? l] piperid -2-acetamide; l- [2- (lH-? m? dazol-1-?) -6-met? lp? r? m? d? n-4-? l] -N- [2- (4-ethoxyphenyl) ethyl] pipepd? n-2-acetarruda; l- [2- (lH-? m? dazol -_-? l) p? pm? d? n-4-? l] -N- [2- (4-ethoxyphenyl) ethyl] p? rrol? dm- 2-carboxamide; 1- [2- (lH-? M? Dazol-1- ^ i) -r met? Let? Lp? R? M? Dm-4-? L] -N- [2- (4-bromophenyl) ethyl] piperia -2-acetamide; l- [2- (lH-? m? dazol ---? l) p? r? m? d? n-4-? l] -N- [2- (4-bromophenyl) ethyl] p? per? d? n-2-acetam? da; 1- [2- (lH-? M? Dazol-1 -? ^ -6-met? Lp? Pm? D? N-4-? L] -N- [2- (4-bromophenyl) ethyl] pipe r ? d? n-2 -a cet amide; l- [2- (lH-? m? dazol- -? l) p? r? m? d? n-4-? l] -N- [2- ( 4-bromofenyl) et? L] p? Rrol? Dm-2-L Arboxamide; 1- [2- (lH-? M? Dazol-1-U) -6-met? Let? Lp? R? M? dm-4-? l] -N-pent i lp ipe ri din-2 -acet amide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N -pentylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N-pentylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethyl-pyrimidin-4-yl] -N- [3- (lH-imidazol-1-yl) propyl] piperidin-2-acetamide; 1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [3- (1H-imidazol-1-yl) propyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-chlorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(3-chlorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(2,4-dichlorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidaz ol-1-yl) pi rimin din-4 -yl] -N- [(2,4-dichlorophenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (1-phenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [l- (phenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3-fluorophenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- [2- (3-ethoxy-4-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (3-ethoxy-4-methoxy phenyl) ethyl] pipe ridin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3-e-toxy-4-methyl-phenyl) ethyl] pipe-ridin-2-acetamide; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-ethoxy-4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-chlorophenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-met ilpyr imidin-4-yl-N- [2- (4-chlorophenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (5-hydroxypentyl) pipe ridin-2 -acetic acid; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N-butylpipethrin-2 -acetic acid; 1- [2- (1H-imidazol-1-yl) -6-met ilpyr imidin-4-yl] -N- [(4-f-luoro-phenyl) (methyl) methyl] -pipe ridin-2 -acetic acid; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(4-f luoro-phenyl) (methyl) methyl] pipe-ridin-2 -acetic acid; 1- [2- (1 H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (2, 5-dimethoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (IH-imide zol-1-yl) -6-met i Ipyrimidin-4-yl] -N- [2- (2,5-dimethoxy phenyl) ethyl] pipe ridin-2 -acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (2,5-dimethoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (4-ethoxy-3-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-ethoxy-3-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] -N- [2- (4-ethoxy-3-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-ethoxy-3-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylethi-pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- [3- (methylethoxy) propyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylethylpyrimidin-4-yl] -N-hexylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N-hexylpiperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl-N-hexylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (cyclohexen-1-yl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (cyclohexen-1-yl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(3-fluoro-5-trifluoromethylphenyl) methyl] piperidin-2-acetarruda; l- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(3-fluoro-5-trifluoromethylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imide zol-1-yl) -pyrimidin-4-yl] -N- [2- (4-methylphenyl) ethyl] piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl-N- [2- (4-ethylphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (3-ethoxypropyl) piperidin-2-acetarruda; l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (3-ethoxypropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N-heptylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pi rimidin-4-yl] -N-heptylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methyl-1-pyrimidin-4-y1] -N-heptylpiperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (3-methoxypropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (1-cyclohexylethyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1-cyclohexylethyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] - N - [(4-trifluoromethoxyphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-trifluoromethyl-to-phenyl) -methyl] -piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (4-fluorophenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (4-fluorophenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (3-bromo-4-methoxyphenyl) ethyl] piperidin-2-acetamide; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [2- (3-bromo-4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (3-brorno-4-methoxyphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [2- (3-bromo-4-methoxyphenyl) ethyl] pyrrolidine-2-carboxamide; l- [2- (lH-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- (3-phenylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- (3-phenylpropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- (3-phenylpropyl) piperidin-2-acetarruda; 1- [2- (lH-imidazol-1-yl) -6-methylethyl-pyrimidin-4-yl-N-octylpiperidin-2-acetarruda; l- [2- (lH-imidazol-l-yl) -6-methylpyrimidin-4-yl-N-octylpiperidin-2-acetamide; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- (1-hydroxy-3-methylbutyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [1- (4-methylphenyl) ethyl] piperidin-2-acetarruda; l- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] -N- [l- (4-methylphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [1- (4-methylphenyl) ethyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [4, 4-diethoxybutyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(4-trifluoromethyl-phenyl) -methyl] -piperidin-2-acetamide; l- [2- (1H-imidazol-1-yl) -pyrimidin-4-yl] -N - [(4-trifluoromethylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl-N - [(4-trifluoromethylphenyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl-N- (3-butoxypropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -N- (3-butoxypropyl) piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [2- (thiophen-2-yl) ethyl] piperidin-2-acetarruda; 1- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [2- (thiophen-2-yl) ethyl] piperidin-2-acetamide; 1- [2- (1 H -imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [3- (pyrrolidin-1-yl) propyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] -N- [(cyclohexyl) methyl] piperidin-2-acetamide; 1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N- [(cyclohexyl) methyl] piperidin-2-acetamide; ethyl ester of 4- [[1- (2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-acetyl] amino] piperidine-1-carboxylic acid ethyl ester of 4- [[1 - [2- (1H-imidazol-1-yl) -6-methylethylpyrimidin-4-yl] piperidin-2-acetyl] amino] piperidine-1-carboxylic acid ethyl ester of 4- [[1- (2- ( lH-imidazol-l-yl) -6-methylpyrimidin-4-yl] piperidin-2-acetyl] amino] piperidine-l-carboxylic acid; l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin- 4-yl] -N- [(4-fluorophenyl) methyl] piperidin-2-acetamide; N - [(1,3-benzodioxol-5-yl) methyl] -l- [3- (lH-imidazol-1- il) phenyl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [3-chloro-5- (1H-imidazol-1-yl) triazin-1-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) purin-6-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [6- (lH-imidazol-1-yl) pyrazin-2-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-propionamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- (lH-imidazol-1-yl) pyrimidin-4-propionamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- (lH-imidazol-1-yl) pyrimidin-4-propionamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [2- (lH-imidazol-1-yl) pyrimidin-4-oxy] acetamide; N- [(1,3-benzodioxol-5-yl) ethyl] -2- [2- (lH-imidazol-1-yl) pyrimidin-4-thio] acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-ethanamine; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N-methylpiperidin-2-ethanamine; N-acetyl-N - [(1,3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2-ethanamine; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -N- (methylsulfonyl) piperidin-2-ethanamine; 4- [2- [[(1,3-benzodioxol-5-yl) methoxy] ethyl] pipe ridin-1-yl] -2- (lH-imidazol-1-yl) pyrimidine; 4- [2 - [[4- (methoxy) phenoxy] propyl] pyrrolidin-1-yl] -2- (lH-imidazol-1-yl) pyrimidine; 4- [2 - [[4- (methoxy) phenoxy] propyl] pyrrol idin-1-yl] -2- (lH-imidazol-1-yl) -6-met ilpyr imidine; 4- [2- [(1,3-benzodioxol-yl) propyl] pyrrolidin-1-yl] -2- (1 H -imidazol-1-yl) pyrimidine; 4- [2 - [(1, 3-benzodioxol-5-yl) prop-2-enyl] pyrrolidin-1-yl] -2- (1 H-imidazol-1-yl) pyrimidine; 4-chloro-2- (1H-imidazol-1-yl) -6- (perhydroazepin-1-yl) pyrimidine; 1- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] pipe ridin-2-ethanol; 4-chloro-2- (1H-imidazol-1-yl) -6- (piperidin-1-yl) pyrimidine; 4-chloro-2- (1H-imidazol-1-yl) -6- (2-ethylpiperidin-1-yl) pyrimidine; 4-f luoro-2- (1H-imidazol-1-yl) -6- [[(3, A-dimethoxyphenyl) ethyl] amino] pyrimidine; 4 - f l u o r o - 2 - (l H - i m i d a z or l - l - i l) - 6 - [[(phenyl) ethyl] amino] pyrimidine; N- [(1,4-benzodioxan-6-yl) methyl] -l- [2- (lH-triazol-1-yl) pyrimidin-4-yl] -4- [(dimethylethoxy) carbonyl] piperazine-2- acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [6- (morpholin-4-yl) -2- (lH-imidazol-1-yl) pyrimidin-4-yl] piperidin-2 -acculent; N- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (1H-imidazol-1-yl) -6-methoxypyrimidin-4-yl] -piperidin-2-acetamide; N- [(1, 3-benzodioxol-5-yl) methyl] -4- [6- [bis (ethoxycarbonyl) methyl] -2- (1H-imidazol-1-yl) pyrimidin-4-yl] -1- [(methoxy) carbonyl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -4- [6- (aminocarbonyl) -2- (1 H -imidazol-1-yl) pyrimidin-4-yl] -1- [(methoxy) carbonyl] piperazin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -3- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -4-methoxybenzamide; 4-chloro-2- (1H-imidazol-1-yl) -6- [(2-methoxyphenyl) amino] pyrimidine; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] indole-6-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrole-2-carboxamide; N- [(3,4-dimethoxy phenyl) ethyl] -2- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] -1,2,3,4-tetrahydroisoquinoline-3-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidin-2-propionamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] pyrrolidin-2-propionamide; N- [(3,4-dimethoxy phenyl) ethyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidine-3-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] -1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] pyrrolidine-3-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] - [2- (lH-imidazol-1-yl) pyrimidin-4-yl] pyrrolidin-3-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] pyrrolidin-3-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -1- [2- (1H-imidazol-1-yl) -6-ethylpyrimidin-4-yl] pyrrolidin-3-acetamide; N - [(3,4-dimethoxyphenyl) ethyl] -1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -acetidine-2-carboxamide; 4- [2- (1H-imide zol-1-yl) pyrimin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) ethyl] morpholin-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] -N - [(1,3-benzodioxan-6-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl-N - [(1,4-benzodioxan-6-yl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl] - N - [(4-methoxyphenyl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N- [(4-methoxyphenyl) ethyl] morpholin-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(3,4-dimethoxyphenyl) ethyl] morpholin-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] - N - [(3,4-dimethoxyphenyl) ethyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) pyrimidin-4-yl-N - [(4-methoxyphenyl) methyl] morpholine-2-carboxamide; 4- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl-N- [(4-methoxyphenyl) methyl] morpholine-2-carboxamide; 4- [2- (1H-imide zol-1-yl) pyrimin-4-yl] -N- [(1,3-benzodioxol-5-yl) methyl] morpholin-2-acetamide; 4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -N - [(1,3-benzodioxol-5-yl) methyl] morpholin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] morpholine-3-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -4- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] morpholine-3-carboxamide; N - [(1, 3-benzodioxol-5-yl) ethyl] -4- [6-ethyl-2- (lH-imidazol-1-yl) pyrimidin-4-yl] morpholine-3-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -4- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] morpholine-3-carboxamide; N - [(4-methoxy phenyl) methyl-4- [2- (lH-imide zol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N- [(4-chlorophenyl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] morpholine-3-carboxamide; N - [(3,4-dichlorophenyl) methyl] -4- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N- [(4-methylphenyl) meth1-4- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] morpholine-3-carboxamide; N- [(3,4-Dimethylphenyl) methyl] -4- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] morpholine-3-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -2- [[2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] acetamide; N- [(1, 4-benzodioxan-6-yl) methyl] -2- [[2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] amino] acetamide; N - [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1, 3-benzodioxol-5-yl) methyl] -l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1,4-benzodioxan-6-yl) methyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1,4-benzodioxan-6-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-l-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1, 3-benzodioxol-5-yl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-eti-pyrimidin-4-yl] -perhydroazepin-2-carboxamide; N - [(1, 3-benzodioxol-5-yl) ethyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(1,4-benzodioxan-6-yl) ethyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(1,4-benzodioxan-6-yl) ethyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(3,4-dimethoxy phenyl) ethyl] -l- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] perhydroazepin-2-carboxamide; N - [(3,4-dimethoxyphenyl) methyl] -l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepine-2-carboxamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [6-chloro-2- (lH-imidazol-1-yl) pyrimidin-4-yl] -perhydroazepin-2-carboxamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -l- [2- (1H-imidazol-1-yl) -6-methylpyrimidin-4-yl] -perhydroazepin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) -6-ethylpyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(1,4-benzodioxan-6-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(1,4-benzodioxan-6-yl) methyl] -l- [2- (1 H -imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(3,4-dimethoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -perhydroazepin-2-acetamide; N - [(3,4-dimethoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(3,4-dimethoxyphenyl) ethyl] -l- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(3,4-dimethoxyphenyl) ethyl-l- [2- (lH-imidazol-1-yl) -6- (methylethyl) pyrimidin-4-yl] perhydroazepin-2-acetamide; N - [(4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetarruda; N - [(4-methoxyphenyl) methyl] -1- [2- (lH-imidazol-1-yl) -6-methylpyrimidin-4-yl] perhydroazepin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl-1- [6-chloro-2- (pyridin-3-yl) pyrimidin-4-yl] piperidin-2-acetamide; N- [(1,3-benzodioxol-5-yl) methyl] -1- [2- (lH-imidazol-1-yl) pyrimidin-4-ylperhydroazepin-2-acetamide; N- [(4-trifluoromethoxyphenyl) methyl] -1- [(2- (1H-imidazol-1-yl) pyrimidin-4-yl] perhydroazepin-2-acetamide; and N- [(4-trifluoromethoxyphenyl) methyl] - 1- [2- (1H-imidazol-1-yl) -6-methy1-pyrimidin-4-yl] -perhydroazepin-2-acetamide; 56. Pharmaceutical composition comprising a compound of formula (I), formula (II), or formula (III): H) q (C (R13) H) r- D (C (R14) R20) n- A ni); wherein: A is -R1, -OR1, -IOINIR'IR2, -P (0) [N (R1) R2] 2, -N (Rx) C (0) R2, -N (R16) C (0 ) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -StOt-R1, -SOjNHCtOR1, -NHS02R22, -S02N (R1) H, -C (0) NHS02R22, and -CH = N0R2; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, u 0; each W is N or CH; Q is selected from the group consisting of a direct bond, -C (0) -, -0-, -CUN-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -NIR ^ lCfOlNlR'lR16, -S (0) tRx (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -0R1, -NfR ^ CtOR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -S OXR1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-C2Q alkyl, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, [C2-C8 alkenyl] -R9, - [ C, -C8 alkynyl] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [X-Cgj-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C_-C8 alkyl] -C (0) N (R1) R2, - [C_-C8 alkyl] -N ( RX) R2, - [C_-C8 alkyl] -R8, - [C2-C8 alkyl] -R10, - [C_-C8 alkyl] -Rn, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) 0H, -CtOJNÍ, -C (= NH) -N (RX) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -NtR ^ C OWR R16, -N (R16) C (0) OR16, -N (R16) C (0) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0- alkyl] C 8] -C (H) [C (0) OR 16] 2 and - [C 1 -C 8 alkyl R 16 alkyl; R 6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl of X-Cg-R 8, - [C 1 -C 8 alkyl] -R 10, - [C 1 -C 8 alkyl] -Ru, acyl, - C (0) R8, -C (0) - [X-Cg-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl , monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0) -R23-N (Rx) C (0) -R23-N (R1) R2, -C (0) -N (R1) -R23-C (0) 0R1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -SO, R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier. 57. Process for synthesizing a compounds of formula (1), formula (II), or formula (III): wherein: A is -R1, -OR1, -C (O) N (R1) R2, -P (O) [N (R1) R2] 2, -NfR ^ CÍOR2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, -SfOXR1, -SO, NHC (0) R1, -NHSO, R22, -SO, N (R1) H, -C (O) NHSO, R22, and -CH-NOR1; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, or O; each W is N or CH; Q is selected from the group consisting of a direct bond, -C (O) -, -O-, -CXN-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (O) R2, -N (R16) C (O) OR2, -N (RX) R21, -NÍR ^ UO? NÍR ^ R16, -SÍOXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -NYR UOJR2, -N (R16) C (O) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, - SÍOXR1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C_-C20 alkyl, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, [C2-C8 alkenyl] -R9, - [ C2-C8 alkynyl] -R9, - [C, -C8 alkyl] -R10 (optionally substituted by hydroxy), - [XC-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R 3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C 1 -C 8 alkyl] -C (O) N (R 1) R 2, - [C 1 -Cg alkyl] -N (RX) R2, - [C1-C8 alkyl] -R8, - [C2-C8 alkyl] -R10, - [X-Cg alkyl -R11, and heterocyclyl (optionally substituted by 1 or more substituents that are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C (0) N (R1) R2, -C (= NH) -N (R1) R2 or O RZ R 2 R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -N (R16) C ( 0) N (Rx) R16, -N (R16) C (0) 0R16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0 alkyl] -C8] -C (H) [C (0) OR16] 2 and - [C -C-alkyl-UOlNtR ^ R16; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl] - [alkyl] C, -C 8] -R 10, - [C 1 -C 8 alkyl] -R 11, acyl, -C (0) R 8, -C (O) - [C 1 -C 8 alkyl] -R 8, alkoxycarbonyl, optionally substituted aryloxycarbonyl optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylcarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (O) -R23-N (R1) R2, -C (0) -R23-N (R1) C (0) -R23-N (R1) R2, -C (O) -N (R1) -R23-C (O) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; comprising the sequential steps of: (a) reacting an equivalent of a compound of formula (XI): WiM- l: xi); X / where W is N or CH; with about one equivalent of a chloro substituted compound of formula (XII): Cl X (XII); U "Y'A: l where X, Y and Z are independently N or C (R19), U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19, and with the proviso that X, Y and Z can not all be C (R19) when U is C (R5); R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, aryl optionally substituted, -OR16, -S (0) t-R16, -N (R16) R21, -H (R16) C (0) i (R1) R16, -N (R16) C (0) OR16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C8 alkyl] -C (H) [C (0) OR16] 2 and - [ C0-C8] -C (O) N (R1) R16, each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl, each R19 is independently hydrogen, alkyl (optionally substituted by hydroxy), cyclopropyl, halo or haloalkyl, each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S 02R22; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; and each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; to produce a compound of the formula (XIII): (xiii); (b) reacting a compound of formula (XIII) on a compound of formula (XlVa), formula (XlVb), or formula (XIVc): Q-R- (¿(R15) H) m 14, / (C (R12) H) q- - (C (R13) H) ¿- (C (R R20) n (XlVa: R17 / (C (R12) H) q- (C (R13) H) r- (c (R14) R20) n-A H (XIVcl) where: A is -R1, -OR1, -CÍONfR ^ R2, -P (O) [N (R1) R2] 2, - ¡(R1) C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, -SIOJ. R1, -SO, NHC (0) R1, -NHS02R22, -S02N (R1) H, - C (O) NHS02R22, and -CH = NOR1; V is N (R4), S, or O; Q is selected from the group consisting of a direct bond, -C (O) -, -O-, -C (= N-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (O) R2, -N (R16) C (O) OR2, -N (RX) R21, -N (R16) C (0) N (Rx) R16, -SYOKR1 (when t is zero) or -NHS02R22, n, q and r can not all be zero; and when Q is a heteroatom and A is -OR1, -NYR ^ UOJR2, -N (R16) C (O) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, -SÍOÍt-R1 (when t is zero) or -NHSO, R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C_-C20 alkyl, optionally substituted cycloalkyl, - [C0-C6 alkyl] -R9, [C-C5 alkenyl] -R9, - [C2-C6 alkynyl] -R9, - [C, -C6 alkyl] -R10 (optionally substituted by hydroxy), - [X-Cg-R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [X-Cg alkyl] -N (R1) R2, - [C_-C8 alkyl] -N (RX) R2, - [C_-C8 alkyl] -R6, - [C, -C8 alkyl] -R10, - [alkyl and heterocyclyl (optionally substituted by 1 or more substituents which are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -CtOlNfRU2, -C (= NH) -N (RL) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R 6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C 1 -C 8 alkyl] -R 8, - [C 1 -C 8 alkyl] -R 10, - [C 1 -C 11 alkyl-R 11, acyl , -C (0) R8, -C (0) - [C_-Ca] -R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, arylfulsonyl optionally substituted, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23- N (R1) R2, -C (0) -R23-N (R1) C (0) -R23-N (R1) R2, -CfO-NfR1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkylene R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, NO, or toluenesulfonyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -SO, R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; to produce a compound of formula formula II) or formula (III). 58. Process to synthesize a compound of formula (I), formula (II) or formula (III): 2 °) n wherein: A is -C (0) N (Rla) R2; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that ü is N only when X is N and Z and Y are CR19; V is N (R4), S, O or C (R4) H; each W is N or CH; Q is selected from the group consisting of a direct bond, -C (O) -, -O-, -C (= N-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (O) R2, -N (R16) C (O) OR2, -NfR ^ R21, -NÍR ^ JCÍOJNÍR R16, -StOXR1 (when t is zero) or -NHSO, R22, n, q and r can not all be zero; and when Q is a heteroatom and A is -OR1, -NYR ^ CIOJR2, -N (R16) C (O) OR2, -N (RX) R21, -N (R16) C (O) N (R1) R16, -SFOít-R1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; Rla is hydrogen; each R1 and R2 are independently selected from the group consisting of hydrogen, X-C ,, alkyl} optionally substituted, optionally substituted cycloalkyl, - [alkyl of C0-C6] -R9, [C2-C6 alkenyl] -R9, - [C2-C6 alkynyl] -R9, - [C2-C6 alkyl] -R10 (optionally substituted by hydroxy), - [X-Cg] -R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [alkyl of -N (R1) R2, - [C_-C8 alkyl] -N (RX) R2, - [ C ^ Cg] -R6, - [C2-C8 alkyl] -R10, - [alkyl of X-Cg-R11, and heterocyclyl (optionally substituted by 1 or more substituents which are selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -CfOJNtR ^ R2, -C (= NH) -N (RX) R2 or R 4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (Rld) R21, -NÍR ^ CÍOJN R ^ R16 , -N (R16) C (0) OR16, -N (R16) C (0) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0-C8 alkyl] -C (H) ) [C (0) OR16] 2 and - [alkyl of Co-CgUUOIN R16; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [C_-C8 alkyl] -R8, - [ C, -C8] -R10, - [C_-C8 alkyl] -Rn, acyl, -C (0) R8, -C (0) - [XC-R8 alkyl, alkoxycarbonyl, optionally substituted aryloxycarbonyl, aralkoxycarbonyl optionally substituted, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, -C (0) -R23-N (R1) C (0) -R23-N (R1) R2, -C (0) -N (R1) -R23-C (O) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkyl; each R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, N02 or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -SO, R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; which comprises photolytically separating the compound of formula (IXa), formula (IXb) or formula (IXc): ; where U, V,, X, Y and Z are as defined in the above; R2, R3, R12, R13, R14, R15, R17 and R20 are as defined above; it is a solid substrate; and L is the linking residue of the formula (IX); wherein the valency not satisfied to the right of the formula represents the point of attachment to the solid substrate and the valence not satisfied to the left of the formula represents the point of attachment to the ligand; to form the compound of formula (I), formula (II) and formula (III) as defined above. 59. Method for treating a condition resulting from an abnormality in the production of nitric oxide, which comprises administering to a mammal having a condition resulting from an abnormality in the production of nitric oxide, a therapeutically effective amount of a compound of formula (I), formula (II), formula (III): H) (C (R13) H) r-fí > ) - (C (R14) R20). n -A); where A is -R1, -OR1, -UOJNÍR ^ R2, -P (O) [N (R1) R2] 2, -N (Rx) C (0) R2, -N (R16) C (0) OR2, -NfR ^ R21, -N (R16) C (O) N (R1) R16, -S (0) tR1, -SOjNHCÍOJR1, -NHSO, R22, -S02N (R1) H, -C (O) NHS02R22 , and -CH = NOR2; each of X, Y and Z are independently N or C (R19); each U is N or C (R5), with the proviso that U is N only when X is N and Z and Y are CR19; V is N (R4), S, u 0; each W is N or CH; Q is chosen from the group consisting of a direct link, -C (0) -, -O-, -C (= N-R1) -, -S (0) t, and -N (R6) -; m is zero or an integer from 1 to 4; n is zero or an integer from 1 to 3; q is zero or 1; r is zero or 1; with the proviso that when Q and V are heteroatoms, m q and r can not all be zero; when A is -OR1, -N (R1) C (0) R2, -N (R16) C (0) OR2, -N (RX) R21, -NfR ^ OJNÍR ^ R16, -SÍOXR1 (when t is zero) or -NHS02R22, n, q and y can not all be zero; and when Q is a heteroatom and A is -OR1, -N (R1) C (0) R2, -N (R16) C (O) OR2, -N (RX) R21, -N (R16) C (0) N (R1) R16, -SÍOJtR1 (when t is zero) or -NHS02R22, myn can not both be zero; t is zero, 1 or 2; N is an optionally substituted N-heterocyclyl; is an optionally substituted carbocyclyl, or optionally substituted N-heterocyclyl; and each R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, optionally substituted cycloalkyl, - [C0-C8 alkyl] -R9, [C2-C8 alkenyl] -R9, - [ C2-C8 alkynyl] -R9, - [C2-C8 alkyl] -R10 (optionally substituted by hydroxy), - [Cx-C8] -R11 (optionally substituted by hydroxy), optionally substituted heterocyclyl; or R1 and R2 together with the nitrogen atom to which they are attached is optionally substituted N-heterocyclyl; R3 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, optionally substituted aryl, haloalkyl, - [C_-C8 alkyl] -C (O) N (R1) R2, - [C_-C8 alkyl] -NfR ^ R2, - [C_-C8 alkyl] -R8, - [C2-C8 alkyl] -R10, - [alkyl of X-Cg-R11, and heterocyclyl (optionally substituted by 1 or more substituents selected from the group consisting of halo, alkyl, alkoxy and imidazolyl); or when Q is -N (R6) - or a direct bond to R3, R3 can additionally be aminocarbonyl, alkoxycarbonyl, alkylsulfonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and -C (= NR18) -NH2; or -Q-R3 taken together, represent -C (0) OH, -C (0) N (RX) R2, -C (= NH) -N (RX) R2 or R4 is selected from the group consisting of hydrogen, alkyl, aryl, aralkyl and cycloalkyl; with the proviso that when A is -R1 or -OR1, R4 can not be hydrogen and when V is CH, R4 can additionally be hydroxy; R5 is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, optionally substituted aralkyl, optionally substituted aryl, -OR16, -S (0) t-R16, -N (R16) R21, -N (R16) C ( 0) N (R1) R16, -N (R16) C (0) OR16, -N (R16) C (O) R16, - [C0-C8 alkyl] -C (O) OR16, - [C0 alkyl] -C8] -C (H) [C (0) OR16] 2 and - [C 1 -C 8 -CO 2 R 4 alkyl; R6 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, - [alkyl of XC-R8, - [C, -C8 alkyl] -R10, - [alkyl of XC-R11, acyl, -C (0) R8 , -C (0) - [C_-C8 alkyl] -R8, alkoxycarbonyl, optionally substituted aryloxycarbonyl, optionally substituted aralkoxycarbonyl, alkylsulfonyl, optionally substituted aryl, optionally substituted heterocyclyl, alkoxycarbonylalkyl, carboxyalkyl, optionally substituted arylfulsonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, optionally substituted arylaminocarbonyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, arylaminosulfonyl, arylsulfonylaminocarbonyl, optionally substituted N-heterocyclyl, -C (= NH) -N (CN) R1, -C (0) -R23-N (R1) R2, - C (O) -R23-N (R1) C (0) -R23-N (R1) R2, -C (0) -N (R1) -R23-C (0) OR1; each of R8 and R9 is independently selected from the group consisting of haloalkyl, cycloalkyl (optionally substituted with halo, cyano, alkyl or alkoxy), carbocyclyl (optionally substituted with one or more substituents that are selected from the group consisting of halo, alkyl and alkoxy), and heterocyclyl, (optionally substituted with alkyl, aralkyl or alkoxy); each R10 is independently selected from the group consisting of halo, alkoxy, optionally substituted aryloxy, optionally substituted aralkoxy, -S (0) t-R22 optionally substituted, acylamino, amino, monoalkylamino, dialkylamino, (triphenylmethyl) amino, hydroxy, mercapto, alkylsulfonamido; each R 11 is independently selected from the group consisting of cyano, di (alkoxy) alkyl, carboxy, alkoxycarbonyl, aminocarbonyl, monoalkylaminocarbonyl and dialkylaminocarbonyl; each R12, R13, R14, R15 R17 and R20 are independently hydrogen or alkylene R16 is independently hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl or cycloalkyl; R18 is hydrogen, NO, or toluenesulfonyl; each R19 is independently hydrogen, alkyl (optionally substituted with hydroxy), cyclopropyl, halo or haloalkyl; each R21 is independently hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, -C (0) R22 or -S02R22; or R21 taken together with R1 and the nitrogen to which they are attached are optionally substituted N-heterocyclyl; or R21, taken together with R16 and the nitrogen to which they are attached is an optionally substituted N-heterocyclyl; each R22 is independently alkyl, cycloalkyl, optionally substituted aryl or optionally substituted aralkyl; and R23 is an amino acid residue; as a single stereoisomer or mixtures thereof, or a pharmaceutically acceptable salt thereof. 60. Method as described in clause 59, in which the condition resulting from an abnormality in the production of nitric oxide, is chosen from the group consisting of multiple sclerosis; attack or cerebral ischemia; Alzheimer's disease, HIV dementia; Parkinson's disease; meningitis; dilated cardiomyopathy and congestive heart failure; atherosclerosis; restenosis or graft stenosis, septic shock and hypotension; hemorrhagic shock; asthma; respiratory distress syndrome in adults, smoking habit or particle-mediated lung damage; pneumonias mediated by pathogens; traumas of various etiologies; rheumatoid arthritis and osteoarthritis; glomerulonephritis; systemic lupus erythematosus; inflammatory bowel diseases such as ulcerative colitis and Crohn's disease; insulin-independent diabetes mellitus; diabetic neuropathy or nephropathy; acute and chronic organ transplant rejection; Transplant vasculopathies; graft versus host disease; psoriasis and other inflammatory skin diseases; and cancer 61. Method as described in clause 60, in which the condition is multiple sclerosis. 62. Method as described in clause 60, in which the condition is rheumatoid arthritis. 63. Method as described in clause 60, in which the condition is dilated cardiomyopathy. 64. Method as described in clause 60, in which the condition is congestive heart failure.