MXPA99007016A

MXPA99007016A - Sulphonamide derivatives

Info

Publication number: MXPA99007016A
Application number: MXPA/A/1999/007016A
Authority: MX
Inventors: Eugene Cantrell Buddy; Richard Baker Stephen; Brian Arnold Macklin; Bleakman David; Leslie Ornstein Paul; John Bleisch Thomas; Maria Escribano Ana; Matsumoto Ken; Elaine Mckennon Tracey; Cr Smith Edward; Lee Simon Richard; Patrick Tizzano Joseph; Michael Zimmerman Dennis; Zarrinmayeh Namideh
Original assignee: Eli Lilly And Company
Priority date: 1997-02-04
Filing date: 1999-07-28
Publication date: 2000-01-01

Abstract

Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula (I):R1-L-NHSO2R2, in which R1 represents an unsubstituted or substituted aromatic or heteroaromatic group;R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group;and L represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring;and pharmaceutically acceptable salts thereof. Also disclosed are novel compounds of formula (I), processes for preparing them and pharmaceutical compositions containing them.

Description

DERIVATIVES OF YOUR PHONAMIDE The present invention relates to the enhancement of glutamate receptor function using certain sulfonamide derivatives. It also relates to novel sulfonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them. In the mammalian central nervous system (CNS), the transmission of nerve impulses is controlled by the interaction between a neurotransmitter, which is released by a transmitting neuron, and a surface receptor in a receiving neuron, which causes excitation of this receptor neuron. L-Glutamate, which is the most abundant neurotransmitter in the central nervous system (CNS), mediates the best excitatory pathway in mammals, and is referred to as an excitatory amino acid (EAA). The receptors that respond to glutamate are called excitatory amino acid receptors (EAA receptors). See Watkins & Evans, ñnn. Rev. Pharmacol. Toxicol , 21, 165 (1981); Monaghan, Bridges, and Cot an, Ann. Rev. Pharmacol. Toxicol , 29, 365 (1989); Watkins, Krogsgaard-Larsen, and Honore, Trans. Pharm. Sci. , 11, 25 (1990). Excitatory amino acids are of great physiological importance, they play a role in Ref .: 30762 a variety of physiological processes, such as a long-term potentiation (learning and memory), the development of synaptic plasticity, motor control, respiration, cardiovascular regulation, and sensory perception. Excitatory amino acid receptors are generally classified into two types. The receptors that are directly coupled in the openings of the cation channels in the cell membrane of the neurons are called ionotropic. "This type of receptor has been subdivided into at least three subtypes, which are defined by the depolarizing actions of the agonists. selective N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and cainic acid (KA) .The second general type of receptor is G protein or the second messenger linked "metabotropic" excitatory amino acid receptor.This second type is coupled to multiple second messenger systems that lead to increased phosphoinositide hydrolysis, activation of phospholipase D, increases or decreases in the c-AMP formation, and changes in ion channel function Schoepp and Conn, Trends in Pharmacol, Sci., 14, 13 (1993) Both types of receptors appear to not only mediate synaptic transmission during pathways or Excitatory pathways, but also participates in the modification of synaptic connections during development and through life. Schoepp, Bockaert, and Sladeczek, Trends in Pharmacol. Sci. , 11, 508 (1990); McDonald and Johnson, -Brain Research Reviews, 15, 41 (1990). The AMPA receptors are linked from four protein subunits known as GluRl to GluR4, while the cainic acid receptors are linked from the subunits GluR5 to GluR7, and KA-1 and KA-2. Wong and Mayer, Molecular Pharmacology 44: 505-510, 1993. It is not yet known how these subunits are combined in the natural state. However, the structures of certain human variants of each subunit have been clarified, and the cell lines expressing the variants of the individual subunit have been cloned and incorporated into assay systems to identify compounds which link or interact with them, and therefore, which can modulate its function. Thus, the European Patent Application, publication number EP-A2-0574257 describes the variants of the human subunits GluRlB, GluR2B, GluR3A and GluR3B. The European patent application, publication number EP-A1-0583917 describes the variant of the human subunit GluR4B.

A distinctive property of AMPA and the caynic acid receptors is its rapid deactivation and desensitization to glutamate. Yamada and Tang, The Journal, of Neuroscience, September 193, 13 (9): 3904-3915 and Kathryn M. Partin, J. Neuroscience, November 1, 1996, 16 (21): 6634-6647. The physiological implications of rapid desensitization, and deactivation of either, are unknown. It is known that rapid desensitization and deactivation of AMPA and / or cainic acid to glutamate receptors can be inhibited by using certain compounds. This action of these compounds is often referred to in the alternative as "potentiation" of the receptors. One such compound, which selectively enhances the function of the AMPA receptor, is cyclothiazide. Partin et al., Neuron. Vol. 11, 1069-1082, 1993. Compounds which potentiate AMPA receptors, similar to cyclothiazide, are often referred to as ampakines or ampacins. The Patent Application Publication International Number WO 9625926 describes a group of phenylthioalkylsulfonamides, S-oxides and homologs, which are those that enhance current membranes, induced by cainic acid and AMPA.

US Patent Specification Number 3,143,549 describes certain phenylalkyl sulfamides, including l-methyl-2-phenylethyl dimethylsulfamide. The compounds are those that have activity in the central nervous system, in particular, anti-anxiety and tranquilizing properties. US Patent Specification No. 3,267,139 discloses certain N '-trimethylacetyl-N-phenylalkyl sulfamides and phenylcyclopropylsulfonamides having activity in the central nervous system and anticonvulsant activity. The compounds are also those that produce Parkinson's-like symptoms in experimental animals. US Patent Specification No. 3,860,723 describes a method of increasing the dietary intake of healthy animals using certain phenylalkylsulfamics. Foye et al., J. Pharm. Sci. (1971), 60 (7), 1095-6 describes certain phenylalkyl methylsulfonamides including N-1-methyl-2-phenylethyl methanesulfonamide, which have hypotensive activity. The British Patent Specification Number No. 1,059,360 discloses certain phenylalkyl sulfamides having activity as sedatives, narcotics and anticonvulsants, including 1- (1-methyl-2-phenylethylaminosulfonyl) piperidine. US Patent Specification No. 4,210,749 describes N-1-methyl-2-phenyl-3-methoxyethyl butanesulfonamides. Gualtieri et al., J. Pharm. Sci. , (1973), 62 (5), 849-851 describes N-1-methyl-2-phenylethyl butanesulfonamides and their evaluation as a mosquito repellent. Foye et al., J. Pharm. Sci. (1979), 68 (5), 591-5 describes methanesulfonamides of N-l-methyl-2- (4-chlorophenyl) ethyl. Foye and Sane, J. Pharm. Sci. (1977), 66 (7), 923-6 describes N-methanesulfonyl and N-trifluoromethanesulfonyl derivatives of amphetamines and certain 4-substituted analogs thereof and their evaluation for the central nervous system and its anorexic effects. The European Patent Application Publication No. EP-A1-0657442 discloses certain naphthyloxyacetic acid derivatives as PEG2 agonists and antagonists. N- (2, 2-diphenylethyl) ethanesulfonamide is described as an intermediate on page 53, line 38. US Patent Specification No. 3,629,332 describes certain sulfonamides of N-aryl fluoralkane and N-heteroarylalkyl as growth modifiers. of the plants, which include N- (alphamethylphenylethyl) trifluoromethanesulfonamide, difluoromethanesulfonamide and fluoromethanesulfonamide. Some of the compounds are also those that have other biological activity, including insecticidal, acaricidal, nematicidal, analgesic and anti-inflammatory activity. The apes or ampakines have been shown to improve memory in a variety of animal trials. Staubli et al. , Proc. Nati Acad. Sci. r Vol. 91, pp 777-781, 1994, Neurobiology, and Arai et al. , The Journal of Pharmacology and Experimental Therapeutics, 278: 627-638, 1996. It has now been found that cyclothiazide and certain sulfonamide derivatives enhance the excitability induced by the human GluR4B receptor agonist expressed in HEK 293 cells. Since cyclothiazide is known to enhance the function of the glutamate receptor in vivo, it is believed that these meanings find that the sulfonamide derivatives will also potentiate the function of the glutamate receptor iri vivo, and therefore, the compounds will exhibit behavior similar to ampacin or ampaquine Accordingly, the present invention provides a method of enhancing the function of the glutamate receptor in a mammal that requires such treatment, which comprises administering an effective amount of a compound of formula R1-L-NHS02R2 I in which, R1 represents a substituted or unsubstituted aromatic or heteroaromatic group; R2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (3 to 6 carbon atoms), fluoroalkyl (1 to 6 carbon atoms), chloroalkyl (1 to 6 carbon atoms), alkenyl (2 to 6 carbon atoms), alkoxy (1 to 6) 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), phenyl which is unsubstituted or substituted by halogen, alkyl (from 1 to 4 carbon atoms) or alkoxy (from 1 to 4 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms) or, together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl group , hexahydroazepinyl or octahydroazocinyl; and L represents an alkylene chain of (2 to 4 carbon atoms) which is substituted or unsubstituted by one or two substituents independently selected from alkyl (1 to 6 carbon atoms), aryl (1 to 6 atoms) carbon) alkyl, alkenyl (of 2 to 6 carbon atoms), aryl (of 2 to 6 carbon atoms) alkenyl and aryl, or by two substituents which together with the carbon atom or carbon atoms to which they are united, they form a carbocyclic ring of (3 to 8 carbon atoms); or a pharmaceutically acceptable salt thereof. According to another aspect, the present invention provides the use of a compound of formula I, or a pharmaceutically acceptable salt thereof as defined herein above for the manufacture of a medicament for enhancing the function of the glutamate receptor. According to still another aspect, the present invention provides the use of a compound of formula I or a pharmaceutically acceptable salt thereof as defined herein above to enhance the function of the glutamate receptor. In this specification, the term "enhancing glutamate receptor function" refers to any increased sensitivity of glutamate receptors, for example AMPA receptors, to glutamate or an agonist, and includes but is not limited to the inhibition of desensitization rapid or deactivation of AMPA glutamate receptors. A wide variety of conditions can be treated or prevented by the compounds of formula I and their pharmaceutically acceptable salts through their action as enhancers of glutamate receptor function. Such conditions include those associated with the hypofunction of glutamate, such as psychiatric and neurological alterations, for example, cognitive alterations, neurodegenerative disorders, such as Alzheimer's disease, age-related dementias, age-induced memory impairment; disturbances of movement, such as tardive dyskinesia, San Vito de Hungtington's disease, myoclonus, and Parkinson's disease; drug-induced disorder states (such as cocaine, amphetamines, alcohol-induced states); depression, impaired attention; impaired attention deficit hyperactivity; psychosis, cognitive deficiencies associated with psychosis; and drug-induced psychosis. The compounds of formula I • can also be used for the improvement of memory (both short term and long term) and the ability to learn. The present invention provides the use of the compounds of formula I for the treatment of each of these conditions. It will be appreciated that the compounds of formula I may contain one or more asymmetric carbon atoms, and may therefore exist in and be used in the form of individual enantiomers. The present invention includes the individual enantiomers of the compounds of formula I. As used herein, the term "aromatic group" suggests the same as aryl, and includes phenyl and a polycyclic aromatic carbocyclic ring such as naphthyl. The term "heteroaromatic group" includes a 5-6 membered aromatic ring, containing one to four heteroatoms selected from oxygen, sulfur and nitrogen, and a bicyclic group consisting of a 5-6 membered ring containing one to four heteroatoms selected from oxygen, sulfur and nitrogen, fused with a benzene ring or other 5-6 membered ring containing one to four atoms selected from oxygen, sulfur and nitrogen. Examples of heteroaromatic groups are thienyl, furyl, oxazolyl, isoxazolyl, oxadiazoyl, pyrazolyl, thiazolyl, thiazolyl, isothiazolyl, imidazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidyl, benzofuryl, benzothienyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, indolyl and quinolyl. . The term "substituted" as used in the term "substituted aromatic or heteroaromatic group" herein means that, one or more (for example one or two) substituents may be present, the substituents are selected from atoms and groups which, when they occur in the compound of formula I, they do not prevent the compound of formula • I from functioning as an enhancer of glutamate receptor function. Examples of the substituents which may be present in a substituted aromatic or heteroaromatic group include halogen; nitro, cyano, hydroxy; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms; alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); hydroxy (from 3 to 8 carbon atoms) cycloalkyl; oxo (from 3 to 8) carbon atoms) cycloalkyl, halo (from 1 to 10 carbon atoms) alkyl (CH2) and X1R9 in which y is 0 or an integer from about 1 to 4, X1 represents O, S, NR10, CO, COO, OCO , CONR11, NR12CO, NR12COCOO, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, morpholino or cycloalkyl (from 3 to 8 carbon atoms) and R10 , R11, R12 and R13 each independently represent hydrogen or alkyl (of 1 to 10 carbon atoms), or R9 and R10, R11, R12 or R13 together with the nitrogen atom to which they are attached, form an azetidinyl group, pyrrolidinyl, piperidinyl or morpholino; N- (from 1 to 4 carbon atoms) alkylpiperazinyl; N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl; thienyl; Furyl oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; alkoxycarbonyl dihydrothiazolyl (from 1 to 4 carbon atoms); alkoxycarbonyl dimethyldihydrothiazolyl (1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R 14 - (La) n-X 2 - (Lb) m in which X 2 represents a bond, O, NH, S, SO, SO 2, CO, CH (OH), CONH, NHCO, NHCONH, NHCOO , COCONH, OCH2CONH, or CH = CH, L and Lb each represents alkylene (of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, and R14 represents a phenyl or heteroaromatic group which is replaced or not replaced by one or two halogen; nitro; cyano; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); 4- (1, l-dioxotetrahydro-l, 2-thiazinyl); halo (from 1 to 10 carbon atoms) alkyl; cyano (from 2 to 10 carbon atoms) alkenyl; phenyl; and (CH2) ZX3R15 in which z is 0 or an integer from 1 to 4, X3 represents O, S, NR16, COCH (OH), COO, OCO, CONR17, NR18CO, NHS02, NHS02NR17, OCONR19 or NR19COO, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 carbon atoms) alkyl, haloalkyl (from 1 to 10 carbon atoms), alkoxycarbonyl (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms, alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), N- (from 1 to 4 carbon atoms) alkoxycarbonyl) (from 1 to 4 carbon atoms) alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl, alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphoril, or a group aromatic or heteroaromatic which is substituted or unsubstituted by one or two of halogen, alkyl (of 1 to 4 carbon atoms), haloalkyl (of 1 to 4 carbon atoms), di (of 1 to 4 carbon atoms) alkylamino Y alkoxy (of 1 to 4 carbon atoms), and R16, R17, R18 and R19, each independently, represents hydrogen or alkyl (of 1 to 10 carbon atoms), or R15 and R16 > R17, R18 or R19, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group. The term alkyl (from 1 to 10 carbon atoms) includes alkyl (from 1 to 8 carbon atoms), alkyl (from 1 to 6 carbon atoms), and alkyl from (1 to 4 carbon atoms). Particular values are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl. The term "alkenyl" (from 2 to 10 carbon atoms) includes alkenyl (from 3 to 10 carbon atoms), alkenyl (from 1 to 8 carbon atoms), alkenyl (from 1 to 6 carbon atoms) and alkenyl (from 1 at 4 carbon atoms The particular values are vinyl and prop-2-enyl The term alkynyl (from 2 to 10 carbon atoms) includes alkynyl (from 3 to 10 carbon atoms), alkynyl (from 1 to 8 carbon atoms). carbon), alkynyl (from 1 to 6 carbon atoms) and alkynyl (from 3 to 4 carbon atoms) A particular value is prop-2-ynyl The term cycloalkyl (from 3 to 8 carbon atoms), as such or in the term cycloalkyloxy (from 3 to 8 carbon atoms), includes monocyclic and polycyclic groups The particular values are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and bicyclo [2.2.2] octane The term includes cycloalkyl (from 3 to 6 carbon atoms: cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl The term hydroxy (of 3 to 8 carbon atoms) cycloalkyl includes hydroxycyclopentyl, such as 3-hydroxycyclopentyl The term oxo (of 3 to 8 carbon atoms) cycloalkyl includes oxocyclopentyl, such as 3-oxocyclopentyl. includes fluorine, chlorine, bromine, and iodine The term halo (1 to 10 carbon atoms) alkyl includes fluoro (1 to 10 carbon atoms) alkyl, such as trifluoromethyl and 2,2,2-trifluoroethyl, and chlorine (from 1 to 10 carbon atoms o) alkyl such as chloromethyl. The term cyano (from 2 to 10 carbon atoms) alkenyl includes 2-cyanohetenyl. The term "alkylene" (of 2 to 4 carbon atoms) includes ethylene, propylene and butylene. A preferred value is ethylene. The term thienyl includes thien-2-yl and thien-3-yl. The term furyl includes fur-2-yl and fur-3-yl. The term "oxazolyl" includes oxazol-2-yl, oxazol-4-yl and oxazol-5-yl. The term isoxazolyl includes isoxazol-3-yl, isoxazol-4-yl and isoxazol-5-yl. The term "oxadiazolyl" includes [1, 2, 4] oxadiazol-3-yl and [1, 2, 4] oxadiazol-5-yl. The term pyrazolyl includes pyrazol-3-yl, pyrazol-4-yl and pyrazol-5-yl.

The term thiazolyl includes thiazol-2-yl, thiazol-4-yl and thiazol-5-yl. The term thiadiazolyl includes [1, 2, 4] thiadiazol-3-yl, and [1, 2, 4] thiadiazol-5-yl. The term isothiazolyl includes isothiazol-3-yl, isothiazol-4-yl and isothiazol-5-yl. The term imidazolyl includes imidazol-2-yl, imidazolyl-4-yl and imidazolyl-5-yl The term triazolyl includes [1, 2, 4] triazol-3-yl and [1, 2, 4] triazol-5-yl . The term tetrazolyl includes tetrazol-5-yl. The term "pyridyl" includes pyrid-2-yl, pyrid-3-yl and pyrid-4-yl. The term "pyridazinyl" includes pyridazin-3-yl, pyridazin-4-yl, pyridazin-5-yl and pyridazin-6-yl. The term "pyrimidyl" includes pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl and pyrimidin-6-yl. The term benzofuryl includes benzofur-2-yl and benzofur-3-yl. The term benzothienyl includes benzothien-2-yl and benzothien-3-yl. The term benzimidazolyl includes benzimidazol-2-yl. The term "benzoxazolyl" includes benzoxazol-2-yl.

The term benzothiazolyl includes benzothiazol-2-yl. The term "indolyl" includes indol-2-yl and indol-3-yl. The term quinolyl includes quinolin-2-yl. The term dihydrothiazolyl includes 4,5-dihydrothiazol-2-yl, and the term alkoxycarbonyldihydrothiazolyl (1 to 4 carbon atoms) includes 4-methoxycarbonyl-4,5-dihydrothiazol-2-yl. In the compounds of formula I, L preferably represents a group of the formula R8 R6 1 I -c- c- ¿* * 7 wherein two of R5, R6 R7 and R8 represent hydrogen and the moiety independently represents hydrogen alkyl (of 1 to 6 carbon atoms), aryl (of 1 to 6 carbon atoms) alkyl, alkenyl (of 2 to 6 carbon atoms) carbon), aryl (2 to 6 carbon atoms) alkenyl or aryl, or together with the carbon atom or carbon atoms to which they are attached form a carbocyclic ring (of 3 to 8 carbon atoms). Preferably, any one or two of R5, R6, R7 and R8 represents alkyl (of 1 to 6 carbon atoms), aryl (of 1 to 6 carbon atoms) alkyl, alkenyl (of 2 to 6 carbon atoms), aryl (2 to 6 carbon atoms) alkenyl or aryl, or two of R5, R6, R7, and R8 together with the carbon atom or carbon atoms to which they are attached, form a carbocyclic ring (from 3 to 8) carbon atoms); and the remainder of R5, R6, R7 and R8 represent hydrogen. Examples of an alkyl group (of 1 to 6 carbon atoms) represented by R 5, R6, R7 and R8 are methyl, ethyl and propyl. An example of an aryl group (of 1 carbon atom) alkyl is benzyl. An example of an alkenyl group (of 2 to 6 carbon atoms) is prop-2-enyl. An example of a carbocyclic ring (of 3 to 8 carbon atoms) is a cyclopropyl ring. More preferably R6 and R7 represent hydrogen. Preferably R5 and R8 each independently represent hydrogen or alkyl (of 1 to 4 carbon atoms), or together with the carbon atom to which they are attached form a carbobicyclic ring (of 3 to 8 carbon atoms). More preferably R8 represents methyl or ethyl, or R5 and R8 together with the carbon atom to which they are attached form a cyclopropyl ring. When R8 represents methyl or ethyl, R5 preferably represents hydrogen or methyl. Especially preferred are the compounds in which R8 represents methyl and R5, R6 and R7 represent hydrogen. Preferably R3 and R4 each represents methyl. Examples of values of R2 are methyl, ethyl, propyl, 2-propyl, butyl, 2-methylpropyl, cyclohexyl, trifluoromethyl, 2,2,2-trifluoroethyl, chloromethyl, ethenyl, prop-2-enyl, methoxyethyl, phenyl, -fluorophenyl or dimethylamino. Preferably R2 is ethyl, 2-propyl or dimethylamino. Examples of R9 values are hydrogen, methyl, ethyl, propyl, isopropyl, t-butyl, ethenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-pyrrolidinyl, morpholino or 2-tetrahydrofuryl. Examples of values for R15 are hydrogen, methyl, ethyl, propyl, isoprosyl, butyl, t-butyl, benzyl, 2,2,2-trifluoroethyl, 2-methoxycarbonylethyl, cyclohexyl, 10-camphor, phenyl, 2-fluorophenyl, 3- fluorophenyl, 2-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 1- (5-dimethylamino) naphthyl, and 2-thienyl. X1 preferably represents O, CO, CONH, or NHCO. z is preferably 0. R9 is preferably alkyl (1 to 4 carbon atoms), alkenyl (2 to 4 carbon atoms, cycloalkyl (3 to 6 carbon atoms, pyrrolidinyl, morpholino or tetrahydrofuryl). groups (CH ^ J and X ^ -R9 and (CH2) zX3R15 include alkoxy (of 1 to 10 carbon atoms), including alkoxy (of 1 to 6 carbon atoms) and alkoxy (of 1 to 4 carbon atoms), such such as methoxy, ethoxy, propoxy, isopropoxy and isobutoxy; alkenyloxy (of 3 to 10 carbon atoms), including alkenyloxy (of 3 to 6 carbon atoms), such as prop-2-enyloxy; alkynyloxy (of 3 to 10 carbon atoms) carbon), including alkynyloxy (of 3 to 6 carbon atoms), such as prop-2-ynyloxy, and alkanoyl (of 1 to 6 carbon atoms), such as formyl or ethanoyl. Examples of particular values for y are 0 and 1. Examples of particular values for z are 0, 1, 2 and 3. L and L preferably each independently represents CH2. A bond O, NH, CO, CH (OH), CONH, NHCONH or OCH2CONH. Preferably the group (CH2) and X1R9 represents CHO; COCH3, OCH3; OCH (CH3) 2; NHCOR9 in which R9 represents methyl, ethyl, isopropyl, t-butyl, ethenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-pyrrolidinyl or morpholino; CONHR9 in which R9 represents cyclopropyl or cyclopentyl; NHC0C00CH3; or 2-tetrahydrofurylmethoxy. Preferably the group (CH2) zX3R15 represents NH2; CH2NH2; (CH2) 2NH2; (CH2) 3NH2; CONH2; CONHCH3; CON (CH3) 2; N (C2H5) 2; CH20H; CH (OH) CH3; CH (OH) CH2CH2; CHO; COCH3; COOH; COOCH3; CH2NHCOOC (CH3) 3; (CH2) 2NHCOOC (CH3) 3 / NHS02CH (CH3) 2; a group of formula (CH2) 2NHS02R15 in which R15 represents CH3, CH2CH3, CH (CH3) 2, (CH2) 2CH3, (CH3) 3 (CH3), benzyl, CH2CF3, 2-methoxycarbonylethyl, cyclohexyl, 10-camphoryl, phenyl, 2-fluorophenyl, 4-fluorophenyl, 2-trifluoromethylphenyl, 4-trifluoromethylphenyl, 4-methoxyphenyl, 1- (2-dimethylamino) naphthyl or 2-thienyl; CH (OH) CH2NHS02CH3; (CH2) 3NHS02CH (CH3) 2; COCH2N (OCOC (CH3) 2S02CH3; C0CH2NHS02CH3; (CH2) 2NHCOR15 in which R15 represents CH3, CH (CH3) 2, CH2CH (CH3) 2 / phenyl, 3-f-lorofenyl, 4-f luorofenyl, benzyl, 2-methoxyphenyl, 4-methoxyphenyl, 2-thienyl, CH = CH, CH = CHCN, OCH3 or 0 (CH2) 3CH3. Examples of particular values for (La) n-X2- (Lb) m are a bond, O, NH, S, SO, S02, CO, CH2, COCH2, COCONH, CH (OH) CH2, CONH, NHCO, NHCONH, CH20, OCH2, OCH2CONH, CH2NH, NHCH2 and CH2CH2.

R 14 is preferably a substituted or unsubstituted phenyl, naphthyl, furyl, thienyl, isoxazolyl, thiazolyl, tetrazolyl, pyridyl, pyrimidyl benzothienyl or benzothiazolyl group. Example of particular values for R14 are phenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2-bromophenyl, 3-bromophenyl, 4-bromophenyl, 4-iodophenyl , 2,3-difluorophenyl, 2, 4-difluorophenyl, 3, 4-dichlorophenyl, 3, 5-dichlorophenyl, 4-cyanophenyl, 3-nitrophenyl, 4-hidroxiiminofenilo, 2-methylphenyl, 4-metilfenilfenilo, 4-ethylphenyl, 3 -propilfenilo, 4 t -butylphenyl, 2-prop-2-enilfenilo, 4- (4- (1, 1-dioxotetrahydro-l, 2-tiazinil) phenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 2 -bromometilfenilo, 2-fluoro-4-trifluoromethylphenyl, 4- (2-cyanoethenyl) phenyl, 4-phenyl, 2-formylphenyl, 3-formylphenyl, 4-formylphenyl, 2-acetylphenyl, 3-acetylphenyl, 4-acetylphenyl, 2- propanoilfenilo, 2- (2-methyl-propanoyl) phenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-butoxyphenyl, 2-hidroximetJlfenilo, 4-hydroxymethylphenyl, 2- (1-hydroxyethyl) phenyl, 3- (1 -hydroxyethyl) phenyl, 4- (l-hydroxyethyl) phenyl, 2- (1-hydro) oxypropyl) phenyl, 4- (1-hydroxypropyl) phenyl, 2- (1-hydroxy-2, 2-dimethyl-propyl) phenyl, 4-trifluoromethoxyphenyl, 2-aminophenyl, 4-aminophenyl, 4-N, N-diethylaminophenyl, 4-aminomethylphenyl, 4- (2-aminoethyl) phenyl, 4- (3-aminopropyl) phenyl, 4-carboxyphenyl, 4-carbamoylphenyl, 4-N-metilcarbamoilfenilo, 4-N, N, -dimetilcarbamoilfenilo, 2-isopropilaminometilfenilo, 4 -t-butoxycarbonylaminomethylphenyl4- (2-isopropoxy-carboxamido) ethylphenyl, 4- (2-t-butoxycarboxamido) ethyl-phenyl, 4-isopropylsulphonylaminophenyl, 4- (2-methanesulfonylamino) ethylphenyl, 4- (2-ethylsulfonylamino) ethyl-phenyl , 4- (3-isopropylsulfonylamino) propylphenyl, 4- (l- (2- (2-propane) sulfonylamino) propyl) phenyl, 4- (2-propylsulphonyl-amino) ethylphenyl, 4- (2-isopropylsulfonylamino) ethylphenyl, - (2-Butylsulfonylamino) ethyl phenyl, 4- (1-isopropyl-sulfonylaminomethyl) ethyl phenyl, 4- (l-hydroxy-2-methanesulfonylamino) ethyl phenyl, 4- (2- (2,2,2-trifluoroethyl)) - sulfonylaminoethyl) phenyl, 4- (2-cyclohexylsulfonylamino) -ethylphenyl, 4- (2- (2,2,2-trifluoroethyl) sulfonylamino) -ethylphenyl), 4- (2-N, N-dimethylaminosulfonylamino) -ethylphenyl, 4- (2-phenylsulfonylaminoethyl) phenyl, 4- (2- (2-fluorophenyl) sulfonylaminomethyl) phenyl, 4- (2- (4-fluorophenyl) sulfonylaminoethyl) phenyl, 4- (2- (2-trifluoromethyl-phenyl) sulfonylaminoethyl) phenyl , 4- (2- (4-trifluoromethylphenyl) sulfonylaminoethyl) phenyl, 4- (2- (4-methoxyphenyl) sulfonylaminoethyl) phenyl, 4- (2- (1- (5-dimethylamino) naphthalenesulfonylamino) ethyl) phenyl, 4- (2- (2-thienyl) sulfonylamino) ethyl) phenyl, 4- (2-benzamidoethyl) -phenyl, - (2- (4-fluorobenzamido) ethyl) phenyl, 4- (2- (3-methoxybenzamido) ethyl) phenyl, 4- (2- (3-fluorobenzamido) -ethyl) phenyl, 4- (2- (4- methoxybenzamido) ethyl) phenyl, 4- (2- (2-methoxybenzamido) ethyl) phenyl, 4- (1- (2- (2-methoxycarbonylethanesulfonylamino) ethyl) phenyl, 4- (1- (2- (10-camphorsulfonylamino) ethyl) phenyl, 4- (1- (2- (benzylsulfonyl-amino) ethyl) phenyl, 4- (2-phenylacetamido) ethyl) phenyl, 4-methanesulfonylaminoethanoylphenyl, 4- (N- (t-butoxycarbonyl) methanesulfonylaminoethanoyl) phenyl, 4- (2- (2-thienylcarboxamido) ethyl) phenyl, thien-2-yl, 5-hydroxy-methylthien-2-yl, 5-formylthien-2-yl, thien-3-yl, 5-hydroxymethyl- 3-yl, 5-formylthien-3-yl, 2-bromothien-3-yl, fur-2-yl, 5-nitrofur-2-yl, fur-3-yl, isoxazol-5-yl, 3-bromoisoxasol- 5-yl, isoxazol-3-yl, 5-trimethylsilyl-isoxazol-3-yl, 5-methyl-isoxazol-3-yl, 5-hydroxyl imethylisoxazol-3-yl, 5-methyl-3-phenylisoxazol-4-yl, 5- (2-hydroxyethyl) isoxazol-3-yl, 5-acetylisoxazol-3-yl, 5-carboxyisoxazol-3-yl, 5-N -methylcarbamoylisoxazol-3-yl, 5-methoxycarbonylisoxazol-3-yl, 3-bromo [1,2,4] oxadiazol-5-yl, pyrazol-1-yl, thiazol-2-yl, 4-hydroxymethyl-thiazol-2-yl , 4-methoxycarbonylthiazol-2-yl, 4-carboxythiazol-2-yl, imidazol-1-yl, 2-sulfhydryl-imidazol-1-yl, [1, 2, 4] triazol-1-yl, tetrazole-5 ilo, 2-methyltetrazol-5-yl, 2-ethyltetrazol-5-yl, 2-isopropyl-tetrazol-5-yl, 2- (2-propenyl) tetrazol-5-yl, 2-benzyl-tetrazol-5-yl , pyrid-2-yl, 5-ethoxycarbonylpyrid-2-yl, pyrid-3-yl, 6-chloropyrid-3-yl, pyrid-4-yl, 5-trifluoromethyl-pyrid-2-yl, 6-chloropyridazin-3-yl , 6-methylpyridazin-3-yl, 6-methoxypyrazin-3-yl, pyrimidin-5-yl, benzothien-2-yl, benzothiazol-2-yl, and quinol-2-yl, Examples of a substituted aromatic or heteroaromatic group or unsubstituted represented by R1 are substituted or unsubstituted phenyl, furyl, thienyl (such as 3-thienyl) and p iridyl (such as 3-pyridyl). R1 preferably represents a naphthyl or phenyl, furyl, thienyl or pyridyl group which is substituted or unsubstituted by one or two substituents independently selected from halogen, nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); hydroxy (from 3 to 8 carbon atoms) cycloalkyl; oxo (3 to 8 carbon atoms) cycloalkyl; halo (from 1 to 10 carbon atoms) alkyl; (CH2) yX1R9 in which y is 0 or an integer of 1 to 4, X1 represents O, S, NR10, CO, COO, OCO, CONR11, NR12CO, NR12C0C00, OCONR13, R9 represents hydrogen, alkyl (of 1 to 10 carbon atoms), alkenyl (3 to 10 carbon atoms, alkynyl (3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, morpholino or cycloalkyl (3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently represents hydrogen or alkyl (1 to 10 carbon atoms), or R9 and R10, R11, R12 or R13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino; N- (from 1 to 4 carbon atoms) alkylpiperazinyl; N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl, dihydrofuryl; dihydrothiopyranyl dihydropyranyl, dihydrothiazolyl, alkoxycarbonyldihydrothiazolyl (1 to 4 carbon atoms) alkoxycarbonyldimethyldihydrothiazolyl (1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R14- (La) n-X2- (Lb) m in which X2 represents a bond, O, NH, S, SO, S02, CO, CH (OH), CONH, NHCONH, NHCO, NHCOO , COCONH, OCH2CONH or CH = CH, La and Lb each represent alkylene (1 to 4 carbon atoms), one of n and m is O oly the other is 0, and R14 represents a phenyl or heteroaromatic group which is unsubstituted or not substituted by one or two of halogen, nitro, cyano, hydroxyimino, alkyl (of 1 to 10 carbon atoms), alkenyl (of 2 to 10 carbon atoms), alkynyl (of 2 to 10 carbon atoms), cycloalkyl ( from 3 to 8 carbon atoms), 4- (1, l-dioxotetrahydro-l, 2-thiazinyl), halo (from 1 to 10 carbon atoms) alkyl, cyano (from 2 to 10 carbon atoms) alkenyl, phenyl , and (CH2) zX3R15 in which z is 0 or an integer of about 1 to 4, X3 represents O, S, NR16, CO, CH (OH), COO, OCO, CONR17, NR18CO, NHS02, NHS02NR17, NHCONH, OCONR19 or NR19COO, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 át carbon atoms) alkyl, haloalkyl (from 1 to 10 carbon atoms), alkoxy (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl ( from 1 to 4 carbon atoms), (N- (from 1 to 4 carbon atoms) alkoxycarbonyl) alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms, alkenyl (from 3 to 10 atoms) carbon), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphor or an aromatic or heteroaromatic group which is substituted or unsubstituted by one or two of halogen, alkyl (from 1 to 4 carbon atoms), haloalkyl (of 1 to 4 carbon atoms), di (of 1 to 4 carbon atoms) alkylamino and alkoxy (of 1 to 4 carbon atoms) and R16, R17, R18 and R19 each one independently represents hydrogen or alkyl (of 1 to 10 carbon atoms) or R15 and R16, R17, R18 or R19 together with the nitrogen atom to which they are attached, form a g rupo azetidinyl, pyrrolidinyl, piperidinyl or morpholino. More preferably, R1 represents 2-naphthyl or a group of formula wherein R20 represents halogen; nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to carbon atoms); cycloalkyl (from 3 to 8 carbon atoms; hydroxy (alkyl from 3 to 8 carbon atoms) cycloalkyl; oxo (from 3 to 8 carbon atoms) cycloalkyl; halo (from 1 to 10 carbon atoms); (CH2) and X1R9 in which y is 0 or an integer from 1 to 4, XI represents O, S, NR, 10U, CO, COO, OCO, CONR 1A1 NR, 1i2Z, CO, OCONR, A13 R3 represents hydrogen, alkyl (from 1 to carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, • morpholino or cycloalkyl (from 3 to 8 carbon atoms) and R10,, R11 , R12 and R13 each independently represent hydrogen or alkyl (of 1 to 10 carbon atoms), or R9, R10, R11, R12 or R13 together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl group or morpholino; N- (from 1 to 4 carbon atoms) alkylpiperazinyl; N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl; thienyl; Furyl oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; tetrazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; alkoxycarbonyldihydrothiazolyl (from 1 to 4 carbon atoms); alkoxycarbonyldimethyldihydrothiazolyl (from 1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; benzothiazolyl; and a group of formula R 14 - (La) n-X 2 - (Lb) m in which X 2 represents a bond 0, NH, S, SO, SO 2, CO, CH (OH), CONH, NHCONH, NHCOO, COCONH , OCH2CONH or CH = CH, NHCO, La and Lb each represents alkylene (of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, R14 represents a phenyl or heteroaromatic group which is substituted or not substituted by one or two of halogen; nitro; cyano alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); 4- (1, l-dioxotetrahydro-l, 2-thiazinyl); halo (from 1 to 10 carbon atoms) alkyl; cyano (from 2 to 10 carbon atoms) alkenyl; phenyl; (CH2) zX3R15 in which z is 0 or an integer from 1 to 4, X3 represents O, S, NR16, CO, CH (OH), COO, OCO, CONR17, NR18CO, NHS02, NHS02R17, NHCONH, OCONR19 or NR19COO , R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 carbon atoms) alkyl, haloalkyl (from 1 to 10 carbon atoms), alkoxycarbonyl (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), (N- (from 1 to 4 carbon atoms) alkoxycarbonyl) alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphor or an aromatic or heteroaromatic group in which it is substituted or not substituted by one or two of halogen, alkyl (of 1 to 4 carbon atoms), haloalkyl (of 1 to 4 carbon atoms), di (of 1 to 4 carbon atoms) carbon) alkyl amino and alkoxy (of 1 to 4 carbon atoms, and R16, R17, R18 and R19 each independently represents hydrogen or alkyl (of 1 to 10 carbon atoms), or R15, R16, R17, R18 or R19 together with the Nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group and R21 represents a hydrogen atom, a halogen atom, an alkyl group (of 1 to 4 carbon atoms) or an alkoxy group (of 1 to 4 carbon atoms). Example of particular values for R20 are fluorine, chlorine, bromine, cyano, hydroxyimino, methyl, ethyl, propyl, 2-propyl, butyl, 2-methylpropyl, 1,1-dimethylethyl, cyclopentyl, cyclohexyl, 3-hydroxycyclopentyl, 3-cyclopentyl , methoxy, ethoxy, Propoxy, 2-proporxi, acetyl, acetylamino, ethylcarboxamido, propilcarboxamido, 1-butanoylamido, t-butylcarboxamido, acriloilamido, 2-pirrolidinilcarboxamido, 2-tetrahidrofurilmetoxi, morfolinocarboxamido, metiloxalilamido, cyclopropylcarboxamido, "I cyclobutylcarboxamido, ciclopentilcarboxamido, ciclohexilcarboxamido, cyclopropylcarbamoyl, ciclopentilcarbamoilo, pyrrolidin-1-yl, morpholino piperidin-1-yl, N-methylpiperazinyl, N-benzylpiperazinyl, 2-thienyl, 3-thienyl, 2-furyl, 3-furyl, isoxazol-3-yl, thiazol-2-yl, tetrazole -5-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, pyrimidin-5-yl, 4,5-dihydrothiazol-2-yl, 4,5-dihydro-4-methoxycarbonyl thiazole-2 -yl, 4, 5-dihydro-4-methoxy-carbonyl-5,5-dimethylthiazol-2-yl, benzothien-2-yl, benzothiazol-2-yl, phenyl, 2-fluorophenyl, 3-fluorophenyl, 2,3 -difluorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 3,5-dichlorophenyl, 3-nitrophenyl, 4-cyanophenyl, 2-methylphenyl, 4-methylphenyl, 4- (4- (1,1-dioxotetrahydro-l, 2) -thiazinyl) phenyl, 3-trifluorome tilphenyl, 4-trifluoromethylphenyl, 4- (2-cyanoethenyl) phenyl, 2-formylphenyl, 3-formylphenyl, 4-formylphenyl, 3-acetylphenyl, 4-acetylphenyl, 4-carboxyphenyl, 2-methoxyphenyl, 4-methoxyphenyl , 2-hydroxymethylphenyl, 4-hydroxymethylphenyl, 3- (1-hydroxyethyl) phenyl, 4- (1-hydroxyethyl) phenyl, 4- (l-hydroxypropyl) phenyl, 2-aminophenyl, 4-aminophenyl, 4-N, N- diethylaminophenyl, 4-aminomethylphenyl, 4- (2-aminoethyl) -phenyl, 4- (3-aminopropyl) phenyl, 4- (2-acetylaminoethyl) -phenyl, 4-t-butoxycarboxylaminoethyl) phenyl, 4- (2-t- butoxycarboxylaminoethyl) phenyl, benzylsulfonylamino, 4-isopropylsulfonylaminophenyl, 4- (2-methanesulfonylaminoethyl) phenyl, 4- (2-ethylsulfonylaminoethyl) phenyl, 4- (2-propylsulfonylaminoethyl) phenyl, 4- (2-butylsulfonylaminoethyl) phenyl, 4- (2 -isopropylsulfonylaminoethyl) phenyl, 4- (l-hydroxy-2-methanesulfonylaminoethyl) phenyl, 4- (2-dimethylaminosulfonylaminoethyl) phenyl, 4- (l- (2- (2-propyl) sulfonylaminopropyl) phenyl, 4- (2- ( 2, 2, 2- trifluoroethyl) sulfonylaminoethyl) fe nyl, 4- (2-cyclohexylsulfonylaminoethyl) phenyl, 4- (2-phenylsulfonylaminoethyl) phenyl, 4- (2- (2-fluorophenyl) sulfonylaminoethyl) phenyl, 4- (2- (4-fluorophenyl) sulfonylaminoethyl) phenyl, 4- (2- (2-trifluoromethylphenyl) sulfonylaminoethyl) phenyl, 4- (2- (4-trifluoromethylphenyl) sulfonylaminoethyl) phenyl, 4- (2- (4-methoxyphenyl) sulfonylaminoethyl) phenyl, 4- (2- (1- (5 - dimethylamino) naphthalenesulfonylamino) ethyl) phenyl, 4- (2- (2-thienyl) sulfonylamino) ethyl) phenyl, 4- (2-benzamidoethyl) -phenyl, 4- (2- (4-fluorobenzamido) ethyl) phenyl, - (2- (3-methoxybenzamido) ethyl) phenyl, 4- (2- (3-fluorobenzamido) -ethyl) phenyl, 4- (2- (4-methoxybenzamido) ethyl) phenyl, 4- (2- (2- methoxybenzamido) ethyl) phenyl, 4- (2- (2-thienylcarboxamido) ethyl) phenyl, 4-carbamoylphenyl, 4- (methylcarbamoylphenyl), 4-dimethylcarbamoylphenyl, 4- (2- (2-methylpropanamido) ethyl) phenyl, - (2- (3-methyl-butanamido) ethyl) phenyl, benzoylmethyl, benzamido, 2-fluorobenzamido, 3-fluorobenzamido, 4-fluorobenzamido, 2 , 4-difluorobenzamido, 3-chlorobenzamido, 4-chlorobenzamido, 4-bromobenzamido, 4-iodobenzamido, 4-cyanobenzamido, 3-methylbenzamido, 4-methylbenzamido, 4-ethylbenzamido, 4-propylbenzamido, 4-t-butylbenzamido, 4-vinylbenzamido , 2- trifluoromethylbenzamido, 3-trifluoromethylbenzamido, 4-trifluoromethylbenzamido, 2-fluoro-4-trifluoromethylbenzamido, 2-methoxybenzamido, 3-methoxybenzamido, 4-methoxybenzamido, 4-butoxybenzamido, 4-phenylphenylcarboxamido, 4-benzylcarboxamido, 4-phenoxymethicarboxamido, -fluorobenzylamino, benzyloxy, 2-fluoro-benzyloxy, 2-hydroxy-2-phenylethyl, 2-fluorophenylcarbamoyl, 4- (1- (2- (2-methoxycarbonylethanesulfonylamino) ethyl) phenyl, 4- (1- (2- (10 -canforsulfonylamino) ethyl) phenyl, 4- (1- (2- (benzylsulfonylamino) ethyl) phenyl, 4- (2-phenylacetamido) -ethyl) phenyl, 4- (methanesulfonylaminoethanoyl) phenyl, 4- (Nt-butoxycarbonyl) methanesulfonylaminoethanoyl) phenyl, 2-thienylcarboxamido, 2-furylcarboxamido, 3- (5-methyl-isoxazolyl) carboxamido, 5-isoxazolylcarboxamido, 2-benzothienilc arboxamide4- (5-methyl-3-phenylisoxazolyl) -carboxamido, 4-pyridylcarboxamido, 2- (5-nitrofuryl) -carboxamido, 2-pyridylcarboxamido, 6-chloro-2-pyridylcarboxamido, 2-thienylsulfonamido, 2-thienylmethylamino, -thienylmethylamino, 2-furylmethylamino, 3-furylmethylamino, 3-acetylureido and 2- (2-thienyl) ethylureido. Examples of particular values for R21 are hydrogen and chlorine. R21 is preferably ortho for R20. Examples of particular values for R1 are 2-naphthyl, 4-bromophenyl, 4-cyanophenyl, 4-benzamidophenyl, 4-methylphenyl, 4-isopropylphenyl, 4-isobutylphenyl, 4-t-butylphenyl, 4-methoxyphenyl, 4-ispropoxyphenyl , 4-cyclopentylphenyl, 4-cyclohexylphenyl, 4- (2-hydroxymethylphenyl) phenyl, 4- (4-hydroxymethylphenyl) -phenyl, 4- (2-furyl) phenyl, 4- (3-furyl) phenyl, 4- (2 -thienyl) -phenyl, 4- (3-thienyl) phenyl, 4- (pyrrolidin-1-yl) phenyl, 4- (piperidin-1-yl) phenyl, 3-chloro-4-piperidin-1-ylphenyl, 4 -benzoyloxyphenyl, 4- (2-fluorophenyl) phenyl, 4- (3-fluorophenyl) phenyl, 4- (2-formylphenyl) phenyl, 4- (3-formylphenyl) -phenyl, 4- (4-formylphenyl) phenyl, - (4-methylphenyl) phenyl and 4- (2-methoxyphenyl) phenyl. Certain compounds of formula I are believed to be novel and are provided as a further aspect of the invention. These compounds can be represented by the formula R ° C- C-NHSO2R2 the R5 R7 wherein R1 represents a naphthyl group or a phenyl, furyl, thienyl or pyridyl group which is substituted or unsubstituted by one or two substituents independently selected from halogen; nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); hydroxy (from 3 to 8 carbon atoms) cycloalkyl; oxo (3 to 8 carbon atoms) cycloalkyl; halo (from 1 to 10 carbon atoms) alkyl; (CH2) and X1R9 in which y is 0 or an integer from 1 to 4, X1 represents O, S, NR10, CO, COO, OCO, CONR11, NR12C0, NR12C0C00, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, morpholino or cycloalkyl (from 3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently represents hydrogen or alkyl (of 1 to 10 carbon atoms), or R9 and R10, R11, R12 or R13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; N- (from 1 to 4 carbon atoms) alkylpiperazinyl; N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl, thienyl; Furyl oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; alkoxycarbonyldihydrothiazolyl (from 1 to 4 carbon atoms); alkoxycarbonyldimethyl-dihydrothiazolyl (1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R 14 - (La) n-X 2 - (Lb) m in which X 2 represents a bond, 0, NH, S, SO, SO 2, CO, CH (OH), CONH, NHCO, NHCONH, NHCOO , COCONH, 0CH2C0NH or CH = CH, La and Lb each represent alkylene (of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, and R14 represents a phenyl or heteroaromatic group which is substituted or unsubstituted by one or two of halogen, nitro, cyano, alkyl (of 1 to 10 carbon atoms), alkenyl (of 2 to 10 carbon atoms), alkynyl (of 2 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), 4- (1, l-dioxotetrahydro-l, 2-thiazinyl), halo (from 1 to 10 carbon atoms) alkyl, cyano (from 2 to 10 carbon atoms) alkenyl, phenyl and (CH2) zX3R15 in which z is 0 or an integer from 1 to 4, X3 represents 0, S, NR16, CO, CH (OH), COO, OCO, CONR17, NR18C0, NHS02, NHS02R17, NHCONH, OCONR19 or NR19COO, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 carbon atoms) alkyl, haloalkyl uilo (from 1 to 10 carbon atoms), alkoxycarbonyl (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms) carbon), (N- (from 1 to 4 carbon atoms) alkoxycarbonyl) alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphor or an aromatic or heteroaromatic group which is substituted or unsubstituted by one or two halogen, alkyl (from 1 to 4 carbon atoms) carbon), haloalkyl (of 1 to 4 carbon atoms), di (of 1 to 4 carbon atoms) alkylamino, and alkoxy (of 1 to 4 carbon atoms), and R16, R17, R18 and R19 each independently represent hydrogen or alkyl (from 1 to 10 carbon atoms), or R15, R16, R17, R18 or R19 together with the nitrogen atom to which they are attached, form an azetidinyl group, pi rrolidinyl, piperidinyl or morpholino; R 2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (from 3 to 6 carbon atoms), fluoroalkyl (from 1 to 6 carbon atoms), chloroalkyl (from 1 to 6 carbon atoms), alkenyl (from 2 to 6 carbon atoms), to 6 carbon atoms), alkoxy (of 1 to 4 carbon atoms)) alkyl (of 1 to 4 carbon atoms), phenyl, which is not substituted by halogen, alkyl (of 1 to 4 carbon atoms) or alkoxy (of 1 to 4 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms), or together with the nitrogen atom to which they are attached, form pyrrolidinyl, piperidinyl, morpholino, or piperazinyl group; and either one of R5, R6, R7 and R8 represent alkyl (of 1 to 6 carbon atoms); aryl (from 1 to 6 carbon atoms) alkyl; alkenyl (2 to 6 carbon atoms); aryl (2 to 6 carbon atoms) alkenyl or aryl or two of R5, R6, R7 and R8 together with the carbon atom or carbon atoms to which they are attached, form a carbocyclic ring (from 3 to 8 carbon atoms) carbon); and the rest of R5, R6, R7 and R8 represent hydrogen; or a pharmaceutically acceptable salt thereof, but excluding N- (2, 2-diphenylethyl) methanesulfonamide and those compounds of formula I in which R7 represents methyl; R5, R6 and R8 represents hydrogen; and (a) R1 represents phenyl, and R2 represents hydrogen; and butyl, fluoromethyl, difluoromethyl, trifluoromethyl, dimethylamino or piperidinyl; or (b) R1 represents 4-chlorophenyl, 4-nitrophenyl or 3-ethoxyphenyl; and R2 represents methyl; or (c) R1 represents 4-nitrophenyl and R2 represents trifluoromethyl. The compounds of formula I can be prepared by reacting a compound of formula R1-L-NH2 II with a compound of formula R¿S02X III wherein X represents a residual atom or group, followed, where necessary and / or desired by the formation of a pharmaceutically acceptable salt. The residual atom or group represented by X can be, for example, a halogen atom such as a chlorine or bromine atom. The reaction is conveniently carried out in the presence of a base, for example an alkali metal hydroxide such as sodium hydroxide, an alkali metal carbonate, such as potassium carbonate, a tertiary amine such as triethylamine or 1,8-diazabicyclo [ 5.4.0] undec-7-ene. Suitable solvents include halogenated hydrocarbons such as dichloromethane. The reaction is conveniently carried out at a temperature in the range of -20 to 100 ° C, preferably -5 to 50 ° C. The compounds of formula I in which R 1 represents a 4-bromophenyl group can conveniently be converted to other compounds of formula I in which R represents another 4-substituted phenyl group by reaction with an appropriate boronic acid derivative, for example, a derivative of benzenoboronic acid. The reaction is conveniently carried out in the presence of a tetrakis (triarylphosphamine) palladium (0) ° catalyst, such as tetrakis (triphenylphosphamine) palladium (0) and a base such as potassium carbonate. Suitable solvents for the reaction include aromatic hydrocarbons, such as toluene. The temperature at which the reaction is conducted is conveniently in the range of 0 to 150 ° C, preferably 75 to 120 ° C. The aromatic bis intermediates employed in the preparation of compounds of formula I can be prepared by reacting a bromoaromatic or bromoheteroaromatic compound with an aromatic or heteroaromatic boronic acid in an analogous manner. The boronic acid derivative used as an initiator material can be prepared by reacting a trialkyl borate, such as triisopropyl borate with an appropriate organolithium compound at reduced temperature. For example, 2-fluoro-benzeneboronic acid can be prepared by reacting 2-fluorobromobenzene with butyllithium in tratrahydrofuran at about -78 ° C to provide 2-fluorophenyllithium, and then reacting this organolithium compound with triisopropyl borate. Alternatively, the compounds of formula I in which R 1 represents a 4-bromophenyl group can be converted to a 4- (trimethylstannyl) phenyl or 4- (tri-n-butylstannyl) phenyl group by treatment of the corresponding bromide with a palladium (0), such as tetrakis (triphenylphosphamine) -palladium (0) and hexaalkyldistannane, wherein the alkyl group is methyl or n-butyl, in an aprotic solvent such as toluene in the presence of a tertiary amine base such as triethylamine , at temperatures in the range of 80 to 140 ° C, preferably 90 to 110 ° C. The compounds of formula I in which R 1 represents a 4- (tri-n-butylstannyl) phenyl group can then be reacted with an aryl or heteroaryl bromide, such as 2-bromothiophen-5-carboxaldehyde, in the presence of a catalyst palladium (0), such as tetrakis (triphenylphosphamine) palladium (0), or a palladium (II) catalyst, such as bis (triphenylphosphamine) palladium (II) dichloride, in an aprotic solvent, such as dioxane, at temperatures in the range from about 80 to 140 ° C, preferably from about 90 to 110 ° C, to provide the corresponding 4- (aryl) phenyl or substituted 4- (heteroaryl) phenyl. The compounds of formula I in which R 1 represents a 4-bromophenyl group can be converted to other compounds of formula I in which R 1 represents a 4-substituted alkyl or cycloalkylphenyl group, such as 4-cyclopentylphenyl by the treatment of the corresponding bromide with a suitable alkyl or cycloalkyl Grignard reagent, such as cyclopentylmagnesium bromide, in the presence of a palladium (II) catalyst, such as [1,1'-bis (diphenylphosphamine) ferrocene] -dichlorladium (II) (PdCl2 { dppf)), in an aprotic solvent, such as diethyl ether at temperatures in the range of -78 ° C to 25 ° C. The compounds of formula I in which R 1 represents a 4-bromophenyl group, can be converted to a 4-substituted carboxyldehydrophenyl (formylphenyl) group by the reaction of the corresponding bromide with the carbon monoxide gas which is pumped into the reaction under atmospheric pressure in the presence of a palladium (II) catalyst, such as bis (triphenyl-phosphine) palladium (II) dichloride and sodium formate in an aprotic solvent, such as dimethylformamide at temperatures in the range of 70 to 110 ° C, preferably at 90 ° C. The compounds of formula I in which R 1 represents a 4-hydroxyphenyl group can be converted to other compounds of formula I in which R 1 represents an alkoxy group by treatment of the corresponding hydroxyphenyl group with an appropriate alkyl halide such as benzyl bromide in the presence of sodium hydride in an aprotic solvent such as dimethylformamide at temperatures in the range of 25 to 100 ° C, preferably 50 to 90 ° C. The compounds of formula II are known or can be prepared by conventional methods, for example, by reducing a corresponding amide or nitrile using borane. Some of the nitriles or amides used as initiator materials can conveniently be prepared by the treatment of an acetonitrile of formula R1CH2CN, for example a substituted phenylacetonitrile such as 4-methoxyphenylacetonitrile or an acetate of formula R1CH2COOR (where R is, for example, alkyl), for example a phenylacetate such as methyl 4-tert-butylphenylacetate, as a strong base of lithium amide, such as lithium bis (trimethylsilyl) amide, and an alkyl halide, such as methyl iodide, in an aprotic solvent, such as tetrahydrofuran, at temperatures in the range of -78 to 25 ° C. The esters are converted to amides by hydrolysis (water, alcohol and sodium or potassium hydroxide) to the acid, conversion of the acid to the acid chloride (S0C12 or (C0C1) 2 plus DMF (1 drop)) after conversion to the amide with aqueous ammonia and a co-solvent such as tetrahydrofuran or dioxane. Certain nitriles used to prepare compounds of formula II can also be conveniently prepared by reacting a corresponding ketone derivative, for example a compound of formula R1C0R8, such as (2-acetyl-5-thien-3-yl) thiophene, with tosylmethyl isocyanide and potassium t-butoxide in dimethyl ether. The ability of the compounds of formula I to enhance the function of the glutamate receptor can be demonstrated using the following test procedures. 96-well plates containing confluent mococaps of HEK cells stably expressing GluR4B (obtained as described in European Patent Application Publication Number EP-A1- 583917) were prepared. The tissue culture medium in the wells was then discharged, and the wells were each washed once with 200 μl of 5NaCa buffer (10 mM glucose, 138 mM sodium chloride, lmM magnesium chloride, chloride • of 5mM potassium, 5mM calcium chloride, N- [2-hydroxyethyl] -piperazine-N- [2-ethanesulfonic acid] lOmM, at pH 7.1 a 7. 3). The plates were then incubated for 60 minutes in the dark with 20 μM of Fluo3-AM dye (obtained from Molecular Probes Inc., Eugene, Oregon) in 5 NaCa buffer in each well. After incubation, each well was washed once with 100 μl of 5NaCa buffer, 200 μl of 5NaCa buffer was added and the plates were incubated for 30 minutes.

The solutions for use in the assay were also prepared as follows, dilutions of 30 μM, 10 μM, 3 μM and 1 μM, of the test compound were prepared using the 5NaCa buffer from a 10 mM solution of the test compound in DMSO. A 100 μM cyclothiazide solution was prepared by adding 3 μl of 100 mM cyclothiazide to 3 ml of NaCa buffer. The control buffer was prepared by adding 1.5 μl of DMSO to 498.5 μl of 5NaCa buffer. Each test was then carried out as follows. 200 μl of 5NaCa buffer was discharged into each well, and replaced with 45 μl of 5NaCa buffer. A first reading was taken using a FLUOROSKAN II fluorometer (Obtained from Labsystems, Needham Heights, MA, USA, a Division of Life Sciences International Pie). The buffer was then discharged from the wells, 45 μl of 5 NaCa buffer was added to the external wells and 45 μl of the test compound solution was added to the internal wells. A second reading was then taken using the fluorometer. The plate was then left in the fluorometer for 5 minutes, and a third reading was taken. The plate was then left in the fluorometer for 5 minutes, and a third reading was taken. 15 μl of a 400 μM glutamate solution (100 μM final glutamate concentration) were then added to each well, and a fourth reading was taken immediately. Approximately three minutes later, a fifth reading was taken. The activities of the test compounds, control and cyclothiazide solutions were determined by subtracting the third of the fourth reading (fluorescence due to glutamate). The activities of the test compounds were expressed relative to those of the 100 μM cyclothiazide. In another assay, HEK293 cells stably expressing human GluR4 (obtained as described in European Patent Application Publication No. EP-AL-0583917) were used in the electrophysiological characterization of AMPA receptor enhancers. The extracellular registry solution contains (in mM): 140 NaCl, 5 KCl, 10 HEPES, 1 MgCl2, 2 CaCl2, 10 glucose, pH = 7.4 with NaOH, 295 mOsm kg "1. The extracellular recording solution contained (in mM): 140 CsCl, lMgCl2, 10 HEPES, 10 HEPES, (N- [2-hydroxyethyl] piperazine-N 1 - [2-ethanesulfonic acid]) 10 EGTA (ethylene-bis (oxyethylene-nitrile) tetraacetic acid), pH = 7.2 with CsOH, 295 mOsm kg-1 With these solutions, record pipettes have a resistance of 2-3 MO Using the blocking technique of total cellular voltage, the cell voltage was blocked at -60mV and control responses were evoked with 100 μM of glutamate. Stable baseline responses to this agonist change, the enhancer was introduced into the extracellular solution by bathing the cells at lower concentrations, and the response to 100 μM glutamate was determined in the presence of this concentration of the enhancer. either in the bath solution and co-applied with the agonist, it was observed or increase in semi-log units until the maximum potentiation. The data obtained in this way were added to the Hill equation, providing an EC50 value, indicator of the power of the enhancer. The enhancer was then washed either from the control solution and the solution containing the agonist to investigate its inverse. Once the control responses to the agonist change were restored, the potentiation of these responses was determined by 100 μM of cyclothiazide by inclusion in both, the bath solution and the solution containing the agonist. In this way, the efficacy of the enhancer, relative to that of the cyclothiazide, can be determined. The compounds exemplified herein were found to give an EC50 value in this assay of at least 30 μM. For example, the compound of Example 28 gave an EC50 value of 203 + 59nM. According to another aspect, the present invention provides a pharmaceutical composition, which comprises a compound of the formula or a pharmaceutically acceptable salt thereof as defined above, and, a pharmaceutically acceptable diluent or carrier. The pharmaceutical compositions are prepared by known procedures using well known and readily available ingredients. In making the compositions of the present invention, the active ingredient will usually be mixed with a carrier, or diluted by a carrier, or bound within a carrier, and may be in the form of a capsule, pouch, paper or other container. When the carrier serves as a diluent, it can be a solid, semi-solid, or liquid material which acts as a vehicle, excipient, or medium for the "active ingredient." The compositions can be in the form of tablets, pills, powders. , dragees, sachets, capsules, elixiris, suspensions, emulsions, solutions, syrups, sprays, ointments containing, for example, up to 10% by weight of the active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and packaged powders sterile Some of the suitable carriers, excipients, and diluents include, lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum, acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, suspension in water, methylcellulose, methyl and propyl hydroxybenzoates, talc, magnesium stearate, and mineral oil. The formulations may additionally include lubricating agents, wetting agents, emulsifying and suspending agents, preservatives, sweetening agents or flavoring agents. The compositions of the invention can also be formulated to provide rapid, sustained or delayed release of the active ingredient after administration to the patient, by employing procedures well known in the art. The compositions are preferably formulated in a unit dosage form, each dosage containing from about 1 mg to about 500 mg, more preferably from about 5 mg to about 300 mg (for example 25 mg) of the active ingredient. The term "unit dosage form" refers to a physiologically discrete unit, suitable as unitary dosages for human subjects and other animals, each unit containing a predetermined amount of the active material calculated to produce the desired therapeutic effect, in association with a pharmaceutically carrier Suitable, diluent, or excipient The examples of the following formulations are illustrative only and are not intended to limit the scope of the invention in any way.

Formulation 1 Hard gelatin capsules were prepared using the following ingredients: Quantity (mg / capsule) • Active ingredient 250 Starch, dry 200 Magnesium stearate 10 Total 460 mg The above ingredients are mixed and filled into hard gelatin capsules in amounts of 460 mg.

Formulation 2 The tablets were made, each containing 60 mg of the active ingredient as follows: Active Ingredient 60 mg Starch 45 mg Microcrystalline cellulose 35 mg Polyvinylpyrrolidone 4 mg Carboxymethyl starch 4.5 mg sodium Magnesium stearate 0.5 mg Talcum 1 Total 150 mg The active ingredient, starch, and cellulose were passed through a U.S. of mesh No.45 and mixed vigorously. The polyvinylpyrrolidone solution was mixed with the resulting powders which were then passed through a U.S. No. 14. The granules thus produced were dried at 50 ° C and passed through a U.S. of mesh No. 18. Sodium carboxymethyl starch, magnesium stearate, and talc, were previously passed through a U.S. No. 60 mesh, then they are added to the granules, which, after being mixed, are compressed in a tablet making machine to obtain tablets each with a weight of 150 mg. The particular dose of the compound administered in accordance with this invention will, of course, be determined by the particular circumstances surrounding the case, including the compound administered, the route of administration, the particular condition to be treated, and particular considerations. The compounds can be administered by a variety of routes including the oral, rectal, transdermal, subcutaneous, intravenous, intramuscular, or intranasal routes. Alternatively, the compound can be administered by continuous infusion. A daily dose will commonly contain from about 0.01 mg / kg to about 100 mg / kg of the active compound of this invention. Preferably, the daily dose will be from about 0.05 mg / kg to about 50 mg / kg, more preferably from about 0.1 mg / kg to about 25 mg / kg.

The following Preparations and Examples illustrate the invention.

Preparation 1 2- (4-bromophenyl) propionitrile A solution of 50.0 g (225.0 mmol) of 4-bromophenyl-acetonitrile and 1.8 g (12.8 mmol) of potassium carbonate in 387 mL of dimethyl carbonate was heated at 180 ° C in a sealed vessel for 16 hours. The solution then cooled, it was diluted with 200 ml of ethyl acetate and washed once with 100 ml of water, once with 100 ml of aqueous sodium bisulfate and once with 100 ml of brine. The organic portion was dried (MgSO), filtered and concentrated in vacuo. The residue was distilled under vacuum through a short path distillation apparatus, to provide 40.3 g (85) of the title compound.

Preparation 2 2- (4-Bromophenyl) propylamine hydrochloride To a solution of 35.2 g (167.6 mmol) of the material from Preparation 1 under reflux in 35.0 mL of tetrahydrofuran, 18.4 mL (184.3 mmol) of 10M borane-di-ethyl-sulfide was added slowly via syringe. The solution was heated under reflux for an additional 1 hour, then the addition was completed. The solution was cooled to room temperature and a saturated solution of hydrogen chloride in methanol was added slowly, until pH 2 was reached. The resulting suspension was concentrated in vacuo. The residue was dissolved in methanol and concentrated in vacuo twice. The resulting solid was suspended in ethyl ether, filtered, rinsed with ethyl ether and dried in vacuo to provide 31.2 g (74%) of the title compound.

Preparation 3 2-Fluorobenzeneboronic acid A solution of 50 g (285.6 mmol) of 2-fluorobromobenzene in 400 mL of tetrahydrofuran was cooled to -78 ° C and 200 mL (320.0 mmol) of 1.6M n-Butyllithium was added via a cannula. The mixture was stirred at -78 ° C for 60 minutes, then 98.9 mL (428.4 mmol) of triisopropyl borate was added via a cannula and stirring continued for 60 minutes. The cooling bath was stirred and the mixture was stirred at room temperature for 1.5 hours, then 150 mL of 6N hydrochloric acid was added and stirring continued for 1.5 hours. To the mixture was added 100 mL of brine, and then the organic layer was separated and the aqueous layer was extracted three times with 30 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. The residue was recrystallized from water to provide 25.2 g (63%) of the title compound.

Preparation 4 2- (4-bromophenyl) -N- (t-butoxycarbonyl) propylamine To a solution of 11.8 g (55.0 mmol) of material from Preparation 2 in 100 mL of chloroform and 100 mL of saturated sodium bicarbonate was added 12.0 g (55.0 mmol) of di-tert-butyl dicarbonate. The solution was stirred at room temperature for 1 hour. The organic layer was separated and the aqueous layer was extracted three times with 30 mL each of chloroform. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to obtain 16.5 g (95%) of the title compound.

Preparation 5 2- (4- (2-fluorophenyl) phenyl) -N (-butoxycarbonyl) propylamine To a degassed or gas-free solution of 12. 5 g (39.8 mmol) of the material of Preparation 4, 6.7 g (47.7 mmol) of the material from Preparation 3 and 8.2 g (59.7 mmol) of potassium carbonate in 140 mL of toluene was added 2.3 g (1.9 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was then cooled to room temperature and 300 mL of water and 150 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 50 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (500 g of silica gel, 10% ethyl acetate / hexane) of the residue afforded 9.3 g (71%) of the title compound.

Preparation 6 2- (4- (2-fluorophenyl) phenyl) propylamine A solution of 9.3 g of material of Preparation 5 in 100 mL of 20% trifluoroacetic acid / dichloromethane was stirred at room temperature for 2 hours. The mixture was concentrated in vacuo to provide 11.7 g of the material. The material was dissolved in 100 mL of ether and washed twice with 50 mL of 1N sodium hydroxide. The organic layer was concentrated in vacuo to give 5.48 g (85%) of the title compound.

Preparation 7 2- (4-isopropylphenyl) propionitrile In a 250 ml flask, 4-isopropylphenylacetonitrile, 8.00 g (50.2 mmol), was dissolved in tetrahydrofuran (150 ml) under a nitrogen atmosphere. The solution was cooled to -78 ° C and lithium bis (trimethylsilyl) amide (1M in tetrahydrofuran, 52.8 ml (52.8 mmol) was added.The resulting mixture was stirred at -78 ° C for 1 hour. iodomethane 3.29 ml (52.8 mmol) was added The resulting mixture was allowed to warm slowly to room temperature over 16 hours then it was quenched with 0.2M hydrochloric acid and extracted twice with diethyl ether The organic fractions were combined, dried (MgSO4) and concentrated under vacuum. Chromatography (SIO2, 20% ethyl acetate / hexanes) gave 6.32 g (73%) of the title compound. Desorption Field of Mass Spectrum: M = 173. Analysis for C12H15: Theory: C, 83.19; H, 8.73; N, 8.08. Found: C, 82.93; H, 8.57, N, 8.02.

Preparation 8 2- (4-isopropylphenyl) propylamine hydrochloride Into a 100 ml flask, fixed with a condenser, 2- (4-isopropylphenyl) propionitrile 1.90 g (11.0 mmol) was dissolved in tetrahydrofuran (70 ml) under a nitrogen atmosphere. A complex of Borane-Methyl sulfide (10.0-10.2 M in tetrahydrofuran, 1.20 mL, 12.1 mmol) was added to the solution and the mixture was heated to reflux for 3 hours. The solution was cooled to room temperature and a saturated solution of hydrochloric acid in methanol was slowly added until a white precipitate formed. The solvent was removed in vacuo and the resulting white solid was triturated (x4) with diethyl ether. Drying under vacuum gave 1.76 g (73%) of the title compound.

Preparation 9 2- (4-Methoxyphenyl) propionitrile Following the method of Preparation 7, but using 5-methoxyphenylacetoneitrile 5.00 g (34.0 mmol), 6.32 g of the title compound was obtained. Field of Desorption of Mass Spectrum: M = 161. Analysis for CIOHJJ.NO: Theory: C, 74.51; H, 6.88; N, 8.69. Found: C, 74.34; H, 6.67; N, 8.93.

Preparation 10 2- (4-Methoxyphenyl) propylamine hydrochloride Following the method of Preparation 8, but using the product of Preparation 9, 2.75 g (17.1 mmol), 2.77 g (81%) of the title compound was obtained. Analysis for C? OH? 6ClN0: Theory: C, 59.55; H, 8.00; N, 6.94. Found: C, 59.33; H, 7.89; N, 6.71.

Preparation 11 2- (4-t-Butylphenyl) methyl propanoate 23.3 mL of lithium bis (trimethylsilyl) amide (1.0 M, 23 mmols) was added dropwise to 4.75 g. (23 mmol) of methyl 4-tert-butylphenylacetate in 100 mL of dry THF at -78 ° C while stirring under nitrogen. The mixture was stirred at this temperature for 45 minutes, then 1.5 mL (24 mmol) of methyl iodide was added dropwise and the solution was stirred for an additional 1 hour at -78 ° C. The mixture was poured into 200 L of H20 and the desired product was extracted with 500 mL of diethyl ether. The organic layer was washed countercurrently once with 500 mL of H20, dried over K2CO3, and concentrated under reduced pressure to obtain 5.12 g of a dark oil. The oil was purified via chromatography on silica gel eluting with a solvent gradient of hexane to hexane / ethyl acetate 19: 1. The fractions containing the desired product were combined and concentrated under reduced pressure to obtain the title compound 2.65 g (53%). Mass spectrum: M 220.

Preparation 1.

Methyl 2- (4- (butyl) nyl) butanoate To g (19 mmol) of methyl 4-tert-butylphenylacetate, 19.5 mL (1.0 M, 19 mmol) of lithium bis (trimethylsilyl) amide and 3.12 g (20 mmol) of ethyl iodide were reacted as described in Preparation 11 providing 5.13 g of a brown oil. Chromatography, eluting with a solvent gradient of hexane to hexane / ethyl acetate 19: 1 gave the title compound 2.35 g (53%).

Mass spectrum: M 234 Preparation 13 Methyl 2- (4- (butyl) phenyl) -2-methylpropanoate 4. 75 g (23 mmol) of methyl 4-tert-butylphenylacetate, 46.6 mL (1.0 M, 46 mmol) of lithium bis (trimethylsilyl) amide, and 6.80 g (48 mmol) of methyl iodide were reacted as described in Preparation 11 to obtain 4.73 g of a crude oil. Chromatography, eluting with a solvent gradient of hexane to hexane / ethyl acetate 19: 1, gave the title compound 2.0 g (37%). Mass Spectrum: M = 234.

Preparation 2- (2-n-phthyl) ethyl propanoate g (23 mmol) of ethyl 2-naphthylacetate, 23.3 mL (1.0 M, 23 mmol) of lithium bis (trimethylsilyl) amide, and 1.5 mL (24 mmol) of methyl iodide were reacted as described in Preparation 11 to obtain 5.71 g of a dark oil. Chromatography eluting with a solvent gradient of hexane to hexane / ethyl acetate 19: 1 gave the title compound 2.85 g (54%). Mass Spectrum: M = 228.

Preparation 15 2- (4- (butylphenyl) propanoic acid 2. 60 g (12 mmol) of the product of Preparation 11 and 1.75 g (42 mMol) of lithium hydroxide were placed in a tri-solvent solution of tetrahydrofuran (189 mL), CH30H (63 mL), and H20 (63 mL) and stirred at room temperature for 16 hours. The mixture was then concentrated under reduced pressure and the resulting white solid was taken up in 200 mL of 1N HCl and the desired product was extracted with 250 mL of ethyl acetate. The organic layer was concentrated under reduced pressure to give the title compound 1.21 g (49%). Mass Spectrum: M = 206.

Preparation 16 2- (4- (butylphenyl) butanoic acid The title compound (2.14 g) was prepared by the method of Preparation 15, starting with the product of Preparation 12, and recrystallized from hexane. Mass Spectrum: M = 220.

Preparation 1 ' 2- (4-t-Butylphenyl) -2-methylpropanoic acid The title compound (1.75 g) was prepared by the method of Preparation 15 starting from the product of Preparation 13, and recrystallized from hexane. Mass spectrum: M = 220.

Preparation 18 2- (2-Naph il) propanoic acid The title compound (3.81 g) was prepared by the method of Preparation 15 starting from the product of Preparation 14, and recrystallized from hexane / ethyl acetate 9: 1. Mass spectrum: M = 214.

Preparation 19 2- (4-t-butylphenyl) propionamide 900 mg (4.4 mmol) of the product of Preparation 15 was added portionwise to oxalyl chloride (10 mL) at room temperature under N2 followed by CH2C12 (10 mL). The initiation of the reaction was carried out by the addition of one drop of DMF. The evolution of the gas appeared and the reaction was stirred at room temperature for 2 hours. The solution was concentrated under reduced pressure to provide an oil. Dioxane (10 mL) was added for solubility and while stirring at room temperature, 28% ammonium hydroxide (10 mL) was added and the reaction was stirred for 16 hours. The solution was then concentrated under reduced pressure to obtain a white solid. This solid was taken up in 50 L of ethyl acetate, washed countercurrently once with 50 mL of H20, dried over K2C3, and concentrated under reduced pressure to provide 770 mg of a solid. Recrystallization from hexane / ethyl acetate 1: 1 gave the title compound 555 mg (61%), Mass Spectrum: M = 205.

Preparation 20 2- (4- (butylphenyl) butanamide The title compound was prepared by the method of Preparation 19, starting with the product of Preparation 16. The purification was carried out by chromatography with silica gel (Chromatotron-2000 micron rotor) eluting with a hexane-ethyl acetate solvent 1 : 1 to obtain 471 mg (60%). Mass Spectrum: M = 219.

Preparation 21 2- (4-butylphenyl) -2-methylpropionamide The title compound was prepared following the method of Preparation 19, starting from the product of Preparation 17. The crude product was triturated with a hexane / ethyl acetate solution 19: 1 for 1/2 hour and filtered to provide 1.16. g of a white solid. Subsequent recrystallization of ethyl acetate / ethanol 1: 1 gave a recovery of 80% as platelets. Mass spectrum: M = 219.

Preparation 22 2- (2-Naphthyl) propionamide The title compound was prepared following the method of Preparation 19, starting from the product of Preparation 18. Recrystallization from hexane / ethyl acetate 1: 1 afforded 1.65 g (90%). Mass Spectrum: M = 199.

Preparation 23 2- (4-t-butylphenyl) propylamine mL of Borane-tetrahydrofuran complex (1.0 M, 0.025 Mol) was added via syringe to 1.10 g (5.4 mmol) of the product of Preparation 19 (60 mL) at room temperature under N2. The mixture was then heated at 60 ° -65 ° C for 16 hours. A saturated solution of HCl / methanol (5 mL) was then added via syringe at room temperature with abundant foam and the solution was then concentrated under reduced pressure. The resulting white solid was taken up in 100 mL of 1N NaOH, and the free amine released was extracted once with 200 mL of diethyl ether. The organic layer was washed countercurrent once with 200 mL of H20, dried over K2CO3, and concentrated under • reduced pressure to obtain 1.21 g of a brown oil.

Chromatography (Chromatotron-2000 micron rotor) eluting with a gradient solvent of ethyl acetate / MeOH 9: 1 to MeOH gave 856 mg (83%) Mass Spectrum: M = 191.

Preparation 24 2- (4-t-butylphenyl) butylamine The title compound 540 mg was prepared as an oil by the method of Preparation 23, starting from the product of Preparation 20. Mass spectrum: M = 205.

Preparation 25 2- (4-t-Butylphenyl) -2-methylpropylamine The title compound 428 mg (42%) was prepared following the method of Preparation 23, starting from the product of Preparation 21, and using methanol as the solvent for the chromatography. Mass spectrum: M = 205.

Preparation 26 2- (2-naphthyl) propylamine The title compound, 450 mg (44%) was prepared as an oil following the method of Preparation 23, starting with the product of Preparation 22, and using methanol as the solvent for chromatography. Mass Spectrum: M = 185.

Preparation 27 Methyl 4- (4-methylphenyl) cyclopropane carboxylate 4 g (19.4 mmol) of methyl 4-tert-butylphenylacetate, 39 mL (1.0 m, 2 Eq.) Of lithium bis (trimethylsilyl) amide, and 3 g (2 Eq.) Of l-bromo-2-chloroethane in 100 mL dry THF, they were reacted as described in Preparation 11, except that the reaction mixture was stirred for one hour at room temperature before lifting. This reaction yielded 4.21 g of a brown oil. This material was purified via chromatography on silica gel eluting with a gradient solvent of hexane to hexane / EtOAc 19: 1 to give the title compound 1.57 g (35%) as a pale yellow solid m.p. 58 ° -60 ° C. Calculated for C? 5H20O2: Theory: C, 77.37; H, 8.81 Found: C, 77.54; H, 8.68.

Preparation 28 1- (4-t-Butylphenyl) cyclopropanecarboxylic acid 1 g (4.3 mmol) of the product from Preparation 27 and 650 mg (15.5 mmol) of lithium hydroxide were placed in a trisolvent solution of THF (66 mL), methanol (22 mL), and H20 (22 mL) and they were reacted as described in Preparation 15 to provide 840 mg of a solid. This material was purified via chromatography on silica gel eluting with hexane / EtOAc 1: 1 as a solvent to give the title compound, 600 mg, (64%) as a white solid. p.f. desc > 150 ° C. Calculated for C? 4H? 802: Theory: C, 77.03; H, 8.31 Found: C, 77.08; H, 8.02.

Preparation 29 1- (4-t-butylphenyl) cyclopropanecarboxamide 580 mg (2.7 mmol) of the product from Preparation 27, oxalyl chloride (10 mL), methylene chloride (10 mL) and one drop of DMF were reacted as described in Preparation 19 to provide 573 mg of the acid chloride raw. Amide conversion was performed with 28% ammonium hydroxide (10 mL) and dioxane (10 mL) as described in Preparation 27 to provide 590 mg of a solid. Trituration in hexane / EtOAc 19: 1 and subsequent filtration gave 510 mg (87%) of the title compound as a white solid. p.f. 178o-180 ° C Calculated for C14H? 9N0: Theory: C, 77.38; H, 8.81; N, 6.45 Found: C, 77.53; H, 8.77; N, 6.39.

Preparation 30 1- (4-t-Butylphenyl) cyclopropylmethylamine 7 mL of the Borane-tetrahydrofuran complex (1.0 M, 7 mmol) and 500 mg (2.3 mmol) of the product from Preparation 29 in THF (50 mL) were reacted as described in Preparation 23 to provide 510 mg of an oil . Purification was performed via chromatography on silica gel eluting with a gradient solvent of EtOAc / methanol 9: 1 to methanol to provide 222 mg (47%) as a solid, m.p. 39 ° -41 ° C. Calculated for C? 4H2? N: Theory C, 82.70; H, 10.41; N, 6.89. Found: C 81.36; H, 10.13; N, 7.24.

Preparation 31 2- (4-Bromophenyl) propylamine hydrochloride To a solution at -15 ° C of 50.0 g (251.2 mmol) of 4-bromo-acetophenone and 49.0 g (251.2 mmol) of tosylmethyl isocyanide in 800 mL of dry dimethoxyethane, a warm solution of 50.7 g (452.2 mmol) of potassium tert-butoxide in 230 mL of tert-butyl alcohol was added. drip at a rate to maintain the temperature below 0 ° C. The reaction was stirred at -5 ° C for 45 minutes after the addition was complete. The cooling bath was removed and the reaction was stirred for 2.5 hours more. The mixture was concentrated in vacuo to a volume of 200 mL and diluted with 500 mL of water. The aqueous mixture was extracted four times with diethyl ether, and the combined organic portions were dried (MgSO4), filtered and concentrated in vacuo. The residue was dissolved in 55 mL of tetrahydrofuran and heated to reflux. To the refluxing solution, 27.6 mL (276.3 mmol) of 10.0 M borane-dimethylsulfide complex was slowly added dropwise. Reflux continued for 20 minutes after the reaction was complete. The mixture was cooled to room temperature and methanol saturated with hydrogen chloride was added very slowly until a pH of 2 was reached. The mixture was concentrated in vacuo and the residue was dissolved in methanol and concentrated in vacuo again. The solid residue was suspended in 125 mL of ethanol, filtered and rinsed with ethanol then with diethyl ether. The white solid was dried in vacuo to obtain 25.4 g (40%) of the title compound. The filtrate was concentrated in vacuo and suspended in diethyl ether. The solid was filtered, rinsed with diethyl ether and dried in vacuo to obtain another 15.6 g (25%) of the title compound.

Preparation 32 2- (4-Methylphenyl) propionitrile The title compound was prepared from 4-methylphenyl acetonitrile as described in Preparation 7. Analysis for CioHn: Theory: C, 82.72; H, 7.64; N, 9.65. Found: C, 82.75; H, 7.42; N, 9.94 Preparation 33 2- (4-Methylphenyl) propylamine hydrochloride The title compound was prepared from the product of Preparation 32 as described in Preparation 8. Mass Spectrum Desorption Field: M = 150 (M-HC1) Preparation 34 2- (4-Benzyloxyphenyl) propionitrile 4-Hydroxyphenylacetonitrile (15.3 g, 114.9 mmol) was dissolved in dimethylformamide (120 mL) and to this was added potassium carbonate (23.78 g, 172.4 mmol), benzyl bromide (20.64 g, 120.6 mmol) and potassium iodide (3.81 g). g, 30.0 mmol). The solution was stirred at room temperature for 6 hours after which water was added. 4-Benzylphenyl-acetonitrile precipitated completely from the solution. The suspension was filtered and the precipitate was washed with water (3x). 24.8 g (97%) was provided as yellow crystals. The title product was prepared from 4-benzyloxyphenylacetonitrile as described in Preparation 7. Providing 76%. Mass Spectrum Desorption Field: M = 237.2. Analysis for C? 6H? 5N0: Theory: C, 80.98; H, 6.37; N, 5.90. Found: C, 80.93; H, 6.46; N, 6.11.

Preparation 35 2- (4-benzyloxyphenyl) propylamine hydrochloride The title compound was prepared from the product of Preparation 34 as described in Preparation 2. Analysis for C? 6H2oClNO: Theory: - C, 59.55; H, 8.00; N, 6.94. Found: C, 59.33; H, 7.89; N, 6.71.

Preparation 36 N-t-Butoxycarbonyl-N- (2- (4-hydroxyphenyl) propyl) 2-propanesulfonamide The product of Example 40 (7.6 g, 23.8 mmol) was dissolved in dichloromethane (100 ml) and to this mixture was added di-tert-butyl dicarbonate (5.71 g, 26.2 mmol) and 4-dimethylaminopyridine (1.45 g, 11.9 mmol ). The reaction was stirred at room temperature for 1 hour. The reaction was washed with a saturated aqueous solution of sodium hydrogen sulfate and brine. The organic fraction was dried over magnesium sulfate and concentrated under vacuum. The protected sulfonamide (9.00 g, 21.0 mmol) was dissolved in ethyl acetate: H20 (5: 1) and ammonium formate (2.0 g, 31.5 mmol) was added to the mixture. Then palladium on carbon (10%) (0.9 g) was added to the reaction and this was stirred at room temperature for 6 hours. The suspension was filtered through Celite and the resulting solution was concentrated in vacuo to give 5.51 g (78%) of the title product. Mass Spectrum Desorption Field: M = 329.1. Analysis for Ci5H23N05S: Theory: C, 54.69; H, 7.04; N, 4.25. Found: C, 53.70; H, 7.72; N, 4.04.

Preparation 37 2- (4-bromophenyl) -1-nitro-l-methylethylene A solution of 30.0 g (162 mmol) of 4-bromobenzaldehyde, 116 mL (1.6 mole) of nitroethane, and 37.5 g (486 mmol) of ammonium acetate in 200 mL of toluene was heated under a Dean and Stark network for 18 hours . The mixture was then cooled to 80 ° C, 1 mL of concentrated sulfuric acid was added, and the mixture was stirred at 80 ° C for 2 hours. The mixture was then cooled to room temperature and washed with 200 mL of brine. The organic layer was separated and the aqueous layer was extracted three times with 60 mL of diethyl ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. The residue was recrystallized from methanol to obtain 18.7 g (47%) of the title compound.

Preparation 38 2- (4-bromophenyl) -1-nitro-l-methylethane A suspension of 1.3 g (33.9 mmol) of lithium aluminum hydride in 55 mL of tetrahydrofuran (THF) was cooled to 0 ° C. A solution of 4.1 g (16.9 mmol) of the material of Preparation 37 in 5 mL of THF was added dropwise. 1.3 mL of water, 1.3 mL of 1M sodium hydroxide and 4.0 mL of water were added in sequence. The mixture was filtered through celite and rinsed with dichloromethane. The organics were concentrated in vacuo to obtain 3.0 g of the title compound (83%).

Preparation 39 N-2- (4-bromophenyl) propyl 2-propanesulfonamide A solution of 15.0 g (59.9 mmol) of the material from Preparation 31 and 18.4 mL (131.8 mmol) of triethylamine in 150 mL was stirred 20 minutes at room temperature, then cooled to 0 ° C and treated as a drop during 5 minutes with 8.1 mL (71.9 mmol) of 2-propylsulfonyl chloride in 10 mL of dichloromethane. After stirring overnight at room temperature, the reaction was washed once with 200 mL of 10% aqueous sodium bisulfate, the layers were separated and the aqueous layer was extracted twice with 100 mL each of dichloromethane. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (500 g of silica gel, 30% ethyl acetate / hexane) of the residue afforded 11.0 g (57%) of the title compound.

Preparation 40 N-2- (4-tri-n-butylstannylpheni) propyl 2-propanesulfonamide To a degassed or gas-free solution of 4.8 g (15.1 mmol) of the preparation material 39, 2.1 mL (15.1 mmol) of triethylamine and 8.0 mL (15.9 mmol) of hexabutyldithine in 35 mL of toluene was added 0.9 g. (0.8 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 16 hours, cooled to room temperature and diluted with 35 L of ethyl acetate. The mixture was washed with 50 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted twice with 50 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (350 g of silica gel, 20% ethyl acetate / hexane) of the residue afforded 3.5 g (44%) of the title compound as a clear, colorless oil.

Analysis calculated for C2H45N02SSn:% C, 54.35; % H, 8.55; % N, 2.64. Found:% C, 54.41; % H, 8.16; % N, 2.74. Mass spectrum: M = 530.

Preparation 41 2- (4-bromophenyl) -N- (t-butoxycarbonyl) ethylamine At room temperature, to a solution of 10.0 g (50.0 mmol) of 4-bromophenethylamine and 11.0 g (50.0 mmol) of di-tert-butyl dicarbonate in 100 mL of chloroform, was added 100 mL of saturated aqueous sodium bicarbonate. The mixture was stirred at room temperature for 1.5 hours, and diluted with 100 mL of water. The organic layer was separated and the aqueous layer was extracted twice with 100 mL each of chloroform. The combined organics were washed once with 100 mL of 10% aqueous sodium bisulfate, dried (NaS04), filtered and concentrated in vacuo to obtain 14.6 g (97%). Mass spectrum: M + l = 301.

Preparation 42 4-cyanophenylboronic acid A solution of 10.0 g (54.9 mmol) of bromobenzenenitrile in 100 mL of tetrahydrofuran was cooled to -85 ° C after which 36.0 mL (57.6 mmol) of 1.6 M n-butyllithium solution in hexane was added. The mixture was stirred for five minutes and 19.0 mL (82.4 mmol) of triisopropylborate was added. The mixture was stirred at -85 ° C for 30 minutes, then warmed-to room temperature in one hour. To the mixture was added 35 mL of 5N hydrochloric acid and stirring continued for 2.5 hours. The mixture was diluted with 100 mL of saturated aqueous sodium chloride and extracted three times with 100 mL each of ethyl ether. The combined organics were dried (MgSO4), filtered and concentrated in vacuo. The residue was recrystallized from water and filtered to obtain 2.0 g '(25%) of the title compound.

Preparation 43 N-2- (4-formylphenyl) propyl 2-propanesulfonamide A solution of 4.6 g (14.5 mmol) of material from Preparation 39 in 50 mL of tetrahydrofuran was cooled to -85 ° C and 19 mL (30.5 mmol) of 1.6M n-Butyllithium was added via syringe. The mixture was stirred at -85 ° C for 30 minutes then 2.2 mL (29.0 mmol) of N, N-dimethyl formamide was added via syringe and stirring was continued for 30 minutes. The mixture was stirred at 0 ° C for 30 minutes and then, 100 mL of brine and 50 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 20 mL each of ether. The combined organic extracts were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (200 g of silica gel, 40% ethyl acetate / hexane) of the residue afforded 2.2 g (56%) of the title compound.

Preparation 44 2-propanesulfonamide of N-2- (4- (4- (l-hydroxy-2- (N- (t-butoxycarbonyl) -methylsulfonamido) ethyl) phenyl) phenyl) propyl A. N- (t-Butoxycarbonyl) methanesulfonamide: To a solution of 15.0 g (157.7 mmol) of methanesulfonamide, 17.6 G (173.5 mmol) of triethylamine and 1.9 g (15.8 mmol) of 4-dimethylaminopyridine in 200 mL of dichloromethane was added 37.9 g (173.5 mmol) of di-t-butyldicarbonate in 200 mL of dichloromethane for 10 minutes. The mixture was stirred at room temperature for 2.25 hours and concentrated in vacuo. The residue was dissolved in 250 mL of ethyl acetate and washed once with 200 mL of 1N hydrochloric acid, once with 100 mL of water and once with 100 mL of saturated aqueous sodium chloride. The organic layer was dried (MgSO), filtered and concentrated in vacuo. The residue was suspended in 100 mL of hexane, filtered and dried in vacuo to obtain 26.1 g (85%) of the title compound. Analysis calculated for CH13N04S:% C, 36.91; % H, 6.71; % N, 7.17. Found% C, 36.97; % H, 6.79; % N, 7.04. Mass spectrum: M + l = 196.

B. N- (4-Bromophenyl) carbonylmethyl-Nt-butoxycarbonyl methanesulfonamide: A solution of 1.0 g (5.1 mmol) of the material from Step A, 1.4 g (5.1 mmol) of 2,4'-dibromoacetophenone and 0.8 g (5.6) mmol) of potassium carbonate in 25 mL of acetonitrile was stirred at room temperature for two hours. The mixture was diluted with 25 mL of ethyl acetate and washed once with 15 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 10 mL each of ethyl acetate. The combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 20% ethyl acetate / hexane) of the residue afforded 1.5 g (76%) of the title compound. Analysis calculated for C? 4H17NBr05S:% C, 42.87; % H, 4.63; % N, 3.57. Found:% C, 43.11; % H, 4.66; % N, 3.37. Mass spectrum: M-l = 391.

C. N- [2- (4-Bromophenyl) 2-hydroxyethyl] -N- (t-butoxycarbonyl) methanesulfonamide: To a solution of 2 * .6 g (6.7 mmol) of the material from Step B in 25 mL of ethanol , 0.3 g was added (6.7 mmol) of sodium borohydride and the mixture was stirred for 16 hours. The mixture was concentrated in vacuo and the residue was partitioned between 25 mL of ethyl acetate and 25 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 10 mL each of ethyl acetate. The combined organics were dried (MgSO4), filtered and concentrated in vacuo to provide 2.6 g (98%) of the title compound. Analysis calculated for C? 4H? 9NBr05S:% C, 42.65; % H, 5.11; % N, 3.55. Found:% C, 42.60; % H, 5.08; % N, 3.46. Mass spectrum: M = 394.

D. To a degassed or gas-free solution of 0.6 g (1.5 mmol) of material from Step C and 0.8 g (1.5 mmol) of material from Preparation 40 in 5 ml of toluene, 0.08 g (0.07 mmol) was added. of tetrakis (triphenylphosphamine) palladium (0). The mixture was refluxed for 16 hours, cooled to room temperature and diluted with 10 L of ethyl acetate. The mixture was washed once with 8 mL of saturated aqueous potassium fluoride, the organic layer was separated and the aqueous layer was extracted four times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.3 g (32%) of the title compound.

Analysis calculated for C26H38N207S2.0. 05 CHC13:% C, 55. 80; % H, 6.84; % N, 5.00. Found:% C, 55.47; % H, 6.93; % N, 4. 72. Mass spectrum: M = 554.

Preparation 45 Dibromoformaldoxime A solution of 150 g (1.6 mole) of glyoxylic acid and 142 g (2.0 mole) of hydroxylamine hydrochloride in 1200 mL of water was stirred for 2 days. To the mixture was slowly added 342 g (4.1 mole) of sodium bicarbonate and 1000 L of dichloromethane. The mixture was cooled to 0 ° C and a solution of 147 mL (2.8 mole) of bromine in 700 mL of dichloromethane was added dropwise.

The mixture was stirred at room temperature for 18 hours. The organic layer was separated and the aqueous layer was extracted three times with 300 mL each of dichloromethane. The combined organic extracts were dried (MgSO 4), filtered and concentrated in vacuo to provide 93.1 g (28%) of the title compound.

Preparation 46 2-trimethylstannylthiazole A. To a solution at -78 ° C of 5.0 g (58.7 mmol) of thiazole in 120 mL of tetrahydrofuran was added 36.7 mL (58.7 mmol) of a 1.6M solution of n-butyllithium in hexane. The mixture was stirred for 20 minutes, after which 11.7 g (58.7 mmol) in 15 mL of tetrahydrofuran was added dropwise over 15 minutes. The cooling bath was stirred and the mixture was stirred for two hours. The mixture was diluted with 100 mL of water and extracted three times with 100 mL of ethyl ether. The combined organics were dried (MgSO4), filtered and concentrated in vacuo. The residue was dissolved in 50 mL of ethyl ether, filtered through silica gel and concentrated in vacuo to provide 3.6 g (24%) of the title compound.

Preparation 47 2-propanesulfonamide of N-2- (4-bromophenyl) ethyl To a solution of 10.0 g (50 mmol) of 4-bromophenethylamine and 7.6 mL (55 mmol) of triethylamine in 150 mL of dichloromethane was added a solution of 6.2 mL (55 mmol) of isopropylsulfonyl chloride in 40 mL of dichloromethane in the form of of drop. The mixture was stirred at room temperature for 18 hours. The mixture was washed with 100 ml of 1N aqueous hydrochloric acid, the aqueous layer was separated and the aqueous layer was extracted once with 100 ml each of dichloromethane. The combined organics were dried (Na2SO4), filtered and concentrated in vacuo to give 6.7 g (44%) of the title compound.

Preparation 48 2-propanesulfonamide of N-2- (4-tri-n-butylstannyl) phenyl) ethyl To a solution of 5.0 g (16.3 mol) of material from Preparation 47, 9.9 g (17.1 mmol) of bis-tri-n-butylstannane and 2.3 mL (16.3 mmol) of triethylamine in 55 mL of toluene, 0.9 g was added. (0.8 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 18 hours. The mixture was cooled to room temperature and 55 mL of 10% aqueous sodium bisulfate was added. The organic layer was separated and the aqueous layer was extracted twice with 20 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (400 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 3.5 g (42%) of the title compound.

Preparation 49 4- (4-bromophenyl) -1, 1-dioxotetrahydro-l, 2-thiazine A. Ethyl 4-bromophenylacetate: A solution of 25.0 g (116.3 mmol) of 4-bromophenylacetic acid. 24.1 g (174.4 mmol) of potassium carbonate and 10.2 mL (127.9 mmol) of iodoethane in 250 mL of acetonitrile was heated at 70 ° C for 16 hours. The mixture was cooled to room temperature, diluted with 200 mL of ethyl acetate and washed once with 200 mL of saturated aqueous sodium bicarbonate. The organic layer was separated and the aqueous layer was extracted three times with 75 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo to provide 16.2 g (57%) of the title compound.

B. Phenyl 3-carbethoxy-3- (4-bromophenyl) propyl sulphonate: A solution of 16.2 g (66.6 mmol) of material from Step A, 4.6 g (33.3 mmol) of potassium carbonate and 4.4 g (16.7 g) mmol) of 18-crown-6 in 130 mL of toluene was heated to 90 ° C and 6.1 g (33.3 mmol) of phenyl vinyl sulphonate in 35 mL of toluene was added dropwise over one hour. The mixture was heated for 16 hours, cooled to room temperature and diluted with 100 mL of ethyl acetate. The mixture was washed once with 100 mL of semi-saturated brine. The organic layer was separated and the aqueous layer was extracted once with 50 mL of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (water 2000, 15% ethyl acetate / hexane) of the residue afforded 4.8 g (17%) of the title compound. Analysis calculated for C? 8H? 905SBr:% C, 50.59; % H, 4.48. Found:% C, 50.61; % H, 4.47. Mass spectrum: M + l = 428.

C. Phenyl 3-carboxy-3- (4-bromophenyl) propylsulfonate: To a solution of 4.8 g (11.3 mmol) of material from Step B in 40 mL of methanol, 6.8 mL of 2N aqueous sodium hydroxide was added. The mixture was stirred at room temperature for 5 hours and concentrated in vacuo. The residue was dissolved in 50 mL of water and extracted three times with 20 mL each of ethyl ether. The aqueous layer was acidified to pH 2 with 10% aqueous sodium bisulfate and extracted four times with 20 mL each of ethyl acetate. The combined ethyl acetate layers were dried (MgSO 4), filtered and concentrated in vacuo to provide 4.1 g (91%) of the title compound. Analysis calculated for C? 6H1505SBr:% C, 48.13; % H, 3.79. Found:% C, 48.17; % H, 3.53. Mass spectrum: M = 399.

D. 3-Carboxamido-3- (4-bromophenyl) propyl sulphonate of phenyl: To a solution at 0 ° C of 4.1 g (10.2 mmol) of material from step C and 2.0 mL (14.3 mmol) of triethylamine at 23 ° C. mL of tetrahydrofuran was added 1.9 mL (14.3 mmol) of isobutyl chloroformate. The mixture was stirred at 0 ° C for 25 minutes, after which 11.2 mL (22.4 mmol) of a 2N solution of ammonia in methanol was added. The cooling bath was stirred and the mixture was stirred for 16 hours. The mixture was diluted with 50 mL of ethyl acetate and washed once with 50 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 25 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (250 g silica gel, 35% acetone / hexane) of the residue afforded 1.7 g (44%) of the title compound. Mass spectrum: M = 398.

E. 4- (4-bromophenyl) -1, 1, 3-trioxotetrahydro-l, 2-thiazine: To a solution at 0 ° C of 9.0 mL (9.0 mmol) of a solution of tetrahydrofuran 1.0 M of tert-butoxide potassium in 15 mL of tetrahydrofuran, a solution of 1.7 g (4.5 mmol) of material from Step D in 14 mL of tetrahydrofuran was added dropwise for 30 minutes. After stirring at 0 ° C for two hours, the cooling bath was stirred and stirring continued for 30 minutes. The mixture was diluted with 25 mL of water and extracted twice with 10 mL each of ethyl ether. The aqueous portion was acidified to pH 2 with 10% aqueous sodium bisulfate and extracted four times with 20 mL each of ethyl acetate. The combined ethyl acetate layers were dried (MgSO), filtered and concentrated in vacuo. Chromatography (75 g silica gel, 0.25% acetic acid / 40% acetone / hexane) of the residue afforded 0.2 g (17%) of the title compound. Analysis calculated for C? 0H? 0N03SBr:% C, 39.49; % H, 3.31; % N, 4.61. Found:% C, 39.74; % H, 3.23; % N. 4.42 Mass Spectrum: M = 304.

F. To a suspension of 0.13 g (0.4 mmol) of material from Step E and 0.2 g (4.9 mmol) of sodium borohydride in 3 mL of dioxane was added 0.4 mL (4.9 mmol) of trifluoroacetic acid slowly via a syringe. After stirring at room temperature for 30 minutes the mixture was refluxed for 5 hours. The mixture was cooled to room temperature, diluted with 3 mL of methanol and stirred for 16 hours. The mixture was stirred and stirring continued for 30 minutes. The mixture was concentrated in vacuo, dissolved in 10 mL of ethyl acetate and washed twice with 5 mL each of 1N hydrochloric acid and once with 5 mL of 20% saturated aqueous sodium bicarbonate / brine. The organics were dried (MgSO), filtered and concentrated in vacuo to provide 0.1 g (89%) of the title compound. Analysis calculated for C? 0H12NO3SBr:% C, 41.39; % H, 4.17; % N, 4.83. Found:% C, 41.10; % H, 4.34; % N, 4.76. Mass spectrum: M - 1 = 289.

Preparation 50 D, L-penicillamine methyl ester hydrochloride Through a suspension of 10.0 g (67.0 mmol) of D, L-penicillamine in 200 mL of methanol, hydrogen chloride was pumped for 5 minutes. The mixture was refluxed for 16 hours, cooled to room temperature and concentrated in vacuo. The residue was suspended in ethyl ether, filtered and dried to provide 12.6 g (94%) of the title compound. Mass spectrum: M = 163.

Preparation 51 N- (t-butoxycarbonyl) -4-tributylstannylaniline A. N- (t-butoxycarbonyl) -4-bromoaniline: To a solution of 6.0 g (39.4 mmol) of 4-bromoaniline in 30 mL of tetrahydrofuran was added 69.8 mL (69.8 mmol) of a 1.0 M solution of bis (trimethylsilyl) ) sodium amide in tetrahydrofuran. To the mixture was added 7.6 g (34.9 mmol) of di-t-butyldicarbonate in 10 mL of tetrahydrofuran. The mixture was stirred at room temperature for one hour and concentrated in vacuo. The residue was dissolved in 50 mL of ethyl acetate and washed once with 50 mL of 10% aqueous sodium bisulfate. The organic layer was separated and the aqueous layer was extracted twice with 25 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (250 g of silica gel, 10% ethyl acetate / hexane) of the residue afforded 5.0 g (53%) of the title compound. Analysis calculated for CnH? 4N02Br:% C, 48.55; % H, 5.19; % N, 5.15. Found:% C, 48.81; % H, 5.29; % N, 4.95. Mass spectrum: M-l = 271.

B. A degassed or gas-free solution of 4.9 g (18.0 mmol) of material from Step A, 2.6 mL (18.9 mmol) of triethylamine, 9.6 mL (18.9 mmol) of bis (tributyltin) and 1. 0 g (0.9 mmol) of tetrakis (triphenylphosphamine) palladium (0) in 45 mL of toluene was heated at 100 ° C for 5 hours. The mixture was cooled to room temperature and diluted with 40 mL of ethyl acetate. The mixture was washed once with 50 mL of 10% aqueous sodium bisulfate, the separated organics and the aqueous layer were extracted three times with 20 mL each of ethyl acetate. The combined organics dried (MgSO4), filtered and concentrated in vacuo. Chromatography (400 g of silica gel, 5% ethyl acetate / hexane) of the residue afforded 1.4 g (16%) of the title compound. Mass spectrum: M + 1 = 483.

Preparation 52 N-2- (4-tri-n-butylstannylphenyl) propyl methanesulfonamide The title compound (3.6 g) was prepared by the method of Preparation 40, starting with the product of Example 1.

Preparation 53 N-2- (4- (3-thienyl) phenyl) propylamine A. 2- (3-thienyl) phenyl-N- (t-butoxycarbonyl) propylamine: To a solution of 0.7 g (2.2 mmol) of Preparation Material 4, 0.3 g (2.4 mmol) of thiophene-3-boronic acid and 0.46 g (3.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water, 0.025 g (0.11 mmol) of palladium (II) acetate and 0.058 g (0.22 mmol) of triphenylphosphamine were added. The mixture was heated at 100 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of brine was added. The organic layer was separated and dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 0.44 g (60%) of the title compound.

B. A solution of 0.4 g (1.3 mmol) of material from Preparation 53A in 4 mL of dichloromethane and 1 mL of trifluoroacetic acid was stirred at room temperature for 3 hours. The mixture was concentrated in vacuo and the residue was dissolved in 5 mL of ethyl acetate and 5 mL of saturated sodium bicarbonate. The organic layer was separated and the aqueous layer was extracted three times with 5 mL of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo to provide 0.21 g (74%) of the title compound.

Preparation 54A 4- (N, N-dibenzylamino) phenylacetonitrile A solution of 4-aminophenylacetonitrile (20 g, 151. 3 mmol) in dry DMF (150 ml) was treated with potassium carbonate (50.1 g, 363.1 mmol), benzyl bromide (54.4 g, 318 mmol), and potassium iodide (5 g, 0.2 30.3 mmol). The reaction mixture was stirred at room temperature for 12 hours. Water (100 ml) was added to the mixture and the organic was extracted with ether (3x200 ml). The combined organic fraction was washed with brine (200 ml), dried over sodium sulfate and concentrated. The crude product was further purified by flash chromatography (Si02, EtOAc: 20% Hexanes) to give 36.2 g (76%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 312.

Preparation 54B l-chloroprop-2-yl sulfonyl chloride To a solution at 0 ° C saturated with chlorine in 100 mL of water was added dropwise 15.7 mL (200 mmol) of propylene sulfide while chlorine was pumped through the mixture. The mixture was stirred at 0 ° C for one hour after the addition. The resulting oil was separated and the aqueous portion was extracted twice with 20 mL each of dichloromethane. The combined organics were dried (CaCl2), filtered and concentrated in vacuo. Vacuum distillation afforded 10.8 g (30%) of the title compound. Mass Spectrum Desorption Field: M-l = 176.

Preparation 55 2- (4- (N, N-dibenzylamino) phenyl) propionitrile A solution at -78 ° C of the material from Preparation 54A (22.8 g, 73 mmol) in dry THF (70 mL) was treated with lithium bis (trimethylsilyl) amide (1M in THF, 76.6 mL, 76.6 mmol). The resulting mixture was stirred at -78 ° C for 1 hour.Methyl iodide (4.8 ml., 76.6 mmol) to the mixture. The reaction mixture was stirred at -78 ° C for 1 hour and gradually allowed to warm to room temperature for 12 hours. Hydrochloric acid (0.2 M, 100 ml) was added to the mixture and the organic was extracted with ether (3x200 ml). The combined organic fraction was washed with water (3X200 ml), brine (200 ml), dried over sodium sulfate and concentrated. The crude product was further purified by flash chromatography (Si02, EtOAc: 20% Ilexan) to give 22.6 g (95%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M = 326.

Preparation 56 2- (4- (N, N-dibenzylamino) phenyl) propylamine hydrochloride A solution at 0 ° C of the material of Preparation 55 (23.6 g, 72.3 mmol) in dry THF (100 ml) was treated with borane methylsulfide (10 M in THF, 8 ml, 80 mmol). The reaction mixture was stirred while refluxing for 3 hours. The solution was cooled down to room temperature and treated with a saturated solution of hydrochloric acid in methanol, until a precipitate formed.

The solvent was removed in vacuo and the resulting white solid was triturated with. ether (4x100 ml). The desired hydrochloric salt was dried under vacuum to give 28.2 g (97%) of the pure product which was used in the next step without further purification. The NMR was consistent with the structure of the proposed title.

Preparation 57 2-propanesulfonamide of N-2- (4- (N, N-dibenzylamino) phenyl) propyl A suspension at 0 ° C of the material of the Preparation 56 (15.2 g, 37.7 mmol) in dichloromethane (125 mL) was treated with triethylamine (11.4 g, 113 mmol) followed by 2-propylsulfonyl chloride (9.2 g, 56.5 mmol). The reaction mixture was stirred at 0 ° C for 1 hour and at room temperature for 6 hours. The reaction was stopped by the addition of water (100 ml). The organic was extracted with dichloromethane (3 x 200 ml). The combined organic fraction was washed with hydrochloric acid (0.2 M 100 ml), water (3X200 ml), brine (100 ml), dried over sodium sulfate, and concentrated in vacuo to give the crude material which was further purified by flash chromatography (Si02, EtOAc: 30% Hexane) to give 10.32 g (63%) of the title compound. The NMR was consistent with the structure of the proposed title. Field of Desorption of the Mass Spectrum: M + = 436.

Preparation 58 N-2- (4-aminophenyl) propyl 2-propanesulfonamide A solution of the product of Preparation 57 (2.5 g, 5.72 mmol) in EtOH (30 ml) was treated with ammonium formate (0.4 g, 6.3 mmol) and palladium on carbon (0.25 g, 10% mole). The reaction mixture was stirred at room temperature for 6 hours. The mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to give 1.36 g of the crude product (93%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 257.

Preparation 59 2-propanesulfonamide of N-t-butyloxycarbonyl-N-2- (4-N, N-dibenzylamino) phenyl) propyl A solution of the product of Preparation 57 (2.5 g, 5.72 mmol) in dry dichloromethane (25 ml) was treated with di-t-butyl dicarbonate (1.47 g, 6.3 mmol) and 4-dimethylaminopyridine (0.37 g, 2.8 mmol). The reaction mixture was stirred at room temperature for 1 hour. The reaction was stopped by the addition of water (20 ml). The organic was extracted with ether (3X30 ml). The combined organic fraction was washed with a 20% solution of sodium hydrogen sulfate (2X30 ml), water (3X100 ml), brine (30 ml), dried over sodium sulfate, and concentrated in vacuo to give the crude material which was further purified by flash chromatography (Si02, EtOAc: 30% Hexane) to give 3.07 g (100%) of the title compound. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M1"= XXX.

Preparation 60 N-t-butyloxycarbonyl-N-2- (4-aminophenyl) propyl 2-propanesulfonamide A solution of the product of Preparation 59 (3.07 g, 5.72 mmol) in EtOH (30 mL) was treated in the form of ammonium (0.54 g, 8.6 mmol) and palladium on carbon (0.3 g, 10% mole). The reaction mixture was stirred at room temperature for 6 hours. The mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to give 1.9 g (93%) of the title compound. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 257.

Preparation 61 2- (4-nitrophenyl) propionitrile A solution at -15 ° C of 4-nitroacetophenone (16.5 g, 100 mmol) and tosylmethyl isocyanide (29.3 g, 150 mmol) in methoxyethyl ether (400 mL) was slowly treated with a solution of room temperature t-butoxide at room temperature. potassium (28 g, 250 mmol) in t-butanol (200 ml). The reaction mixture was stirred at -15 ° C for 1 hour and then allowed to warm to room temperature overnight. Water (100 ml) was added to the mixture and the organic extracted with ether (3X200 ml). The combined organic fraction was washed with water (3X200 mlj, brine (100 ml), dried over sodium sulfate, and concentrated in vacuo to give the crude material which was further purified by flash chromatography (Si02, EtOAc: hexane at 30 ° C). %) to give 13.6 g (77%) of the title compound The NMR was consistent with the structure of the proposed title: Mass Spectrum Desorption Field: M + = 225.Preparation 62 2- (4-nitrophenyl) propylamine A solution at 0 ° C of the material of Preparation 61 (11.8 g, 67 mmol) in dry THF (200 ml) was treated with tetrahydrofuranborane (1M in THF, 72 ml, 72 mmol). The reaction mixture was stirred at room temperature for 16 hours. A solution of THF: MeOH (1: 1, 10 ml) and sodium hydroxide (5 N, 40 ml) was added to the reaction mixture stepwise and the mixture was refluxed for 5 hours. The reaction mixture was allowed to cool to room temperature. The organic was extracted with dichloromethane (3X100 ml). The combined organic fraction was washed with water (3X200 ml), brine (100 ml), dried over potassium carbonate, and concentrated in vacuo to give the crude material, which was further purified by flash chromatography.

(Si02, MeOII: 5% CII2C12) to give 8.5 g (71%) of the pure product. The NMR was consistent with the structure of the proposed title. Destroying Field of Mass Spectrum: M + 181.

Preparation 63 N-2- (4-nitrophenyl) propyl 2-propanesulfonamide At 0 ° C, a suspension of the material from the Preparation 62 (8.2 g, 45.3 mmol) in dichloromethane (200 ml) was treated with 1,8-diazabicyclo [5.4.0] undec-ene (7.6 g, 49.8 mmol) followed by 2-propylsulfonyl chloride (12 g, 49.8 g). mmol). The reaction mixture was stirred at 0 ° C for 1 hour and at room temperature for a further 12 hours. The reaction was stopped by the addition of water (100 ml). The organic was extracted with dichloromethane (3X100 ml). The combined organic fraction was washed with water (3X200 ml), brine (100 ml), dried over potassium carbonate, and concentrated in vacuo to give the crude material, which was further purified by flash chromatography (SIO2, EtOAc: MeOH to 30%) to give 8.9 g (68%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = Preparation 64 N-2- (4-aminophenyl) propyl 2-propanesulfonamide A degassed or gas-free solution of the material of Preparation 63 (8.75 g, 31 mmol) in ethyl acetate (200 ml) was treated with palladium on carbon (4 g, 50 mol%). The mixture was shaken under 60 psi of hydrogen gas for 2 hours. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to obtain 7.44 g (94%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 257.

Preparation 65 N-2- (4-benzylamino) phenyl) propyl 2-propanesulfonamide In a pressure tube, a degassed or gas-free solution, of bromide from Preparation 39 (3 g, 9.7 mmol) in anhydrous toluene (40 ml) was treated with benzylamine (1.27 ml, 11.6 mmol), tris (dibenzylideneacetone) palladium (0) (170 mg, 0.19 mmol), S (-) - BINAP (360 mg, 0.58 mmol), and sodium t-butoxide (1.95 mg, 20.3 mmol). The reaction mixture was stirred at 80 ° C for 16 hours. The mixture was cooled to room temperature. Water (5 ml) was added to the mixture and the organic was extracted with ether (3X% ml). The combined organic fraction was washed with water (2X5 ml), brine (5 ml), dried over sodium sulfate, and concentrated in vacuo to give the crude product, which was purified by flash chromatography (SÍO2, EtOAc: hexanes al 20%) to give 1.9 g (58%) of a yellow oil as the title compound. The NMR was consistent with the structure of the proposed title.

Preparation 66 2- (4-aminophenyl) propyl 2-propanesulfonamide A solution of the product of Preparation 65 (1.5 g, 4.33 mmol) in EtOAc (30 mL) was treated in the form of ammonium (0.41 g, 6.5 mmol) and palladium on carbon (0.15 g, 10% mole). The reaction mixture was stirred at room temperature for 3 hours. The mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo to give 1.1 g of the title compound. (98%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 257.

Preparation 67 N-2- (4- (carboxy (phenyl) propyl) 2-propanesulfonamide) A solution at -85 ° C of the product from Preparation 39 (220 mg, 0.65 mmol) in dry THF (2 mL) was treated with a solution of n-butyllithium (0.87 mL, 1.37 mmol, 1.6 M solution). The reaction mixture was stirred for 10 minutes at -85 ° C and then carbon dioxide gas was pumped into the mixture for 1 minute. The reaction mixture was allowed to warm to room temperature. Water (5 ml) and concentrated hydrochloric acid (3 ml) were added to the mixture and the organic was extracted with ether (3X10 ml). The combined organic fractions were washed with water (2X10), brine (5 ml), dried over sodium sulfate, and concentrated in vacuo to provide 210 mg (98%) of the pure product which was used in the next step without purification * additional.

Preparation 68 N-t-butyloxycarbonyl-4-piperazineacetophenone A solution of the 4-piperazinoacetophenone (10 g, 49 mmol) in tetrahydrofuran: water (200 ml, 1: 1 mixture) was treated with potassium carbonate (8.43 g, 58 mmol) and di-t-butyl dicarbonate (13.1 g, 53.9 mmol). The reaction mixture was stirred at room temperature for 3 hours. Water (300 ml) was added to the mixture and the organic was extracted with ethyl acetate (3X100 ml). The combined organic fraction was washed with water (2X200 ml), brine (100 ml), dried over sodium sulfate, and concentrated in vacuo to 17.41 g of the yellowish solid. The crude product was further purified by Prep LC 2000 eluting with EtOAc: 30% Hexanes to give 10.9 g (73%) of the title compound as a white solid. Field of Mass Spectrum Desorption: M + = 305.

Preparation 69 2- (N-t-Butyloxycarbonyl-4-piperazinophenyl) propionitrile, The title compound 1.8 g (16%) was prepared as a solid following the method of Preparation 61, starting from the product of Preparation 68 and using tosylmethyl isocyanide. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 316.

Preparation 70 2- (N-t-Butyloxycarbonyl-1-4-piperazinophenyl) propylamine The title compound 1.78 g (100%) was prepared as a solid following the method of Preparation 62, starting from the product of Preparation 69 and using borane methylsulfide. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 319.

Preparation 71 2-propanesulfonamide of N-2- (N-t-butyloxycarbonyl-4-piperazinophenyl) propyl The title compound 676 mg (61%) was prepared as a solid, following the method of Preparation 63, starting from the product of Preparation 70 and using borane methylsulfide. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 319.

Preparation 72 N-2- (4-piperazinophenyl) propyl 2-propanesulfonamide A solution of the material from Preparation 71 (800 mg, 1.88 mmol) in dichloromethane (10 ml) was treated with trifluoroacetic acid (5 ml). The reaction mixture was stirred at room temperature for 3 hours. A 1N solution of sodium hydroxide (10 ml) was added to the mixture and the organic was extracted with dichloromethane (3 × 20 ml). The combined organic fraction was washed with water (2 × 200 ml), brine (20 ml), dried over potassium carbonate, and concentrated in vacuo to give 560 mg (91%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 319.

Preparation 73 N-2- (N-benzoyl-4-piperazinophenyl) propyl 2-propanesulfonamide A solution at 0 ° C of the material of Preparation 72 (80 mg, 0.25 mmol) in dichloromethane (10 ml) was treated with triethylamine (28 mg, 0.27 mmol) and benzoic anhydride (61 mg, 0.27 mmol). The reaction mixture was stirred at 0 ° C for 30 minutes. Water (5 ml) was added to the mixture and the organic was extracted with dichloromethane (3X5 ml). The combined organic fraction was washed with water (2X5 ml), brine (5 ml), dried over potassium carbonate, and concentrated in vacuo to give 94 mg (87%) of the title compound. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 430.2 Preparation 74 3-tributyltin-2-cyclopenten-1-one A solution at -20 ° C of hexabutylditin (4.6 g, 7.9 mmol) in THF (15 ml) was treated with nBuLi (4.9 ml, 7.9 mmol, 1.6 M solution in hexanes). The reaction mixture was stirred at -20 ° C for 30 minutes and then cooled to -78 ° C.

The mixture was treated with 3-ethoxy-2-cyclopenten-1-one (1.0 g, 7. 9 mmol) and the reaction mixture was stirred at -78 ° C for 30 minutes. A saturated aqueous solution of ammonium chloride (2 ml) followed by water (30 ml) and the organic extracted with hexanes (2 x 30 ml). The combined organic layers were washed with brine (20 ml), dried over magnesium sulfate and concentrated in vacuo. This gave 2.7 g, (93%) of the crude product which was used without further purification.

The NMR was consistent with the structure of the proposed title.

Preparation 75 2-propanesulfonamide of N-2- (4- (1- (3-oxo) cyclopentyl) phenyl) propyl A solution of the product of preparation 39 (1.0 g, 3.22 mmol) in dry, degassed or gas-free THF (15 ml) was treated with the product of Preparation 74 (1.8 g, 4.83 mmol), and dichlorobis (triphenylphosphamine) palladium (II) (45 mg, 0.06 mmol). The reaction mixture was heated to reflux for 48 hours. The mixture was cooled and partitioned between acetonitrile and hexanes. The acetonitrile layer was washed with hexanes (3 x 20 ml), then concentrated in vacuo. The crude product was further purified by flash chromatography (SiO2, 70% EtOAc-hexanes) to give 0.71 g. (68%) of the title compound as a pure product. The NMR was consistent with the structure of the proposed title.

Mass Spectrum Desorption Field: M + = 321.1.

Preparation 76 1- (4-bromophenyl) -2,5-dimethylpyrrole 4-bromoaniline (56.0 g, 0.33 Mol), 2,5-hexanedione (37.6 g, 0.33 Mol), and acetic acid (5 ml) were placed in Toluene (500 ml) and heated under reflux for 8 hours using a deán stark network to remove the water from the reaction. The reaction was cooled to room temperature and concentrated under reduced vacuum. The resulting oil was taken up in ethyl acetate, washed once each with 2N hydrochloric acid, 2N NaOH, and H20, dried over Na2SO4, and concentrated under reduced vacuum to give a brown solid. The material was purified by flash chromatography on silica gel eluting with hexanes. The concentration of the appropriate fractions gave 55.0 gm of a slightly yellow solid. (68%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 249 p.f. 71-73 ° C.

Preparation 77 1- (4-acetylphenyl) -2,5-dimethylpyrrole A solution at -30 ° C of the material of Preparation 76 (25.0 g, 0.1 mol) ~ in dry ether (500 ml) was treated with n-butyllithium (70 ml of 1.6 M, 0.12 mol) and stirred for one hour at -30 ° C. N, N-dimethylacetamide (9.7 g, 0.12 mol) was added and the reaction continued at this temperature for 4 hours. The reaction was then allowed to warm to room temperature and stirred overnight at this temperature. In the morning, the mixture was diluted with ethyl acetate and the combined organic layers were washed once each with 2.0 N hydrochloric acid and H20, dried over Na2SO, and concentrated under reduced vacuum to provide a white solid. The material was triturated in hexane and filtered to provide 12.8 mg of a white solid, m.p. 106-108 ° C (60%). The NRM was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 214.

Preparation 78 1- (4- (1-cyano) ethylphenyl) -2,5-dimethylpyrrole The initial ketone of Preparation 77 (44.3 g, 0.21 mol), tosylmethyl isocyanide (40.6 g, .21 mol), potassium t-butoxide (39.2 g, 0.35 mol), and t-butyl alcohol (250 ml) were added. were reacted in ethylene glycol dimethyl ether (500 ml) as described in Preparation 61 to provide a yellow solid. Purification was performed by flash chromatography on silica gel eluting with hexane / ethyl acetate 4: 1 to provide 32.3 mg of yellow crystals. P.f. 79-80 ° C (68%). Mass Spectrum Desorption Field: M + = 225.

Preparation 79 1- (4- (2- (2-cyano) propyl) phenyl) -2,5-dimethylpyrrole A solution at -78 ° C of material from the Preparation 78 (7.0 g, 32 mmol) in dry tetrahydrofuran (100 ml) was treated with lithium (bis) trimethylsilylamide (40 ml of 1. OM, 1.3 equivalents). After stirring 30 minutes at this temperature, methyl iodide (2.6 ml, 1.3 equivalents) was added dropwise and the reaction was allowed to warm to room temperature. The mixture was diluted with ether and the combined organic layers were washed once with H20, dried over K2CO3, and concentrated under reduced vacuum to provide 7.61 gm of a yellow solid. The material was purified via chromatography on silica gel eluting with a hexane / ethyl acetate solvent 9: 1 to give 6.30 gm of a yellow solid, m.p. 135-137 ° C (83%). Destroying Field of Mass Spectrum: M + +1 239.

Preparation 80 1- (4- (2- (3-amino-2-methyl) propyl) phenyl-2,5-dimethylpyrrole The nitrile of Preparation 79 (6.23 g, 26.2 mmol) in tetrahydrofuran (250) was treated with a THF-borane complex (17.1 mL, 1.0 M) as described in Preparation 62 to provide 6.37 gm of a foam. This material was purified via chromatography on silica gel eluting with a gradient solvent of dichloromethane to dichloromethane / methanol 9: 1 to provide 4.08 gm of a white solid, m.p. 95-97 ° C (65%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 243.

Preparation 81 2-propanesulfonamide of N-2- (4- (2,5-dimethylpyrrole) phenyl) -2-methylpropyl The amine of Preparation 80 (4.0 g, 16.6 mmol) was treated with 1,8-diazabicyclo [5.4.0] undec-ene (3.28 g, 1.3 equivalents) and 2-propylsulfonyl chloride (3.2 ml, 1.3 equivalents) in dichloromethane (80 ml) as described in Preparation 63 to provide 6.1 gm of a yellow oil. This material was purified via chromatography on silica gel eluting with a 4: 1 hexane / ethyl acetate isocratic solvent to give 4.3 gm of a white solid, m.p. 110-112 ° C (62%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 349.

Preparation 82 N-2- (4-aminophenyl) -2-methylpropyl 2-propanesulfonamide The sulfonamide of Preparation 81 (2.17 g, 6.3 mmol) was treated with hydroxylamine hydrochloride (2.0 g, 13.8 mmol) and potassium hydroxide (0.96 g, 20.0 mmoi) in absolute ethanol (16 ml) and water (6 ml) . This mixture was refluxed for 24 hours. The solution was cooled to room temperature and poured into H20 and the desired product was extracted into ether. The organic layer was washed countercurrent once with H20, dried over K2CO3 and concentrated under reduced pressure to provide 1.57 gm, as an oil. This material was purified via chromatography on silica gel eluting with a 1: 1 hexane / ethyl acetate isocratic solvent to provide 1.41 gm of a white solid, m.p. 87-88 ° C (84%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 271.

Preparation 83 N, N- (4-nitrophenyl) propyl N, N-dimethylsulfamide Nitroamine from Preparation 62 (1.8 g, 0.01 Mol) was treated with 1,8-diazobicyclo [5.4.0] ndec-ene (1.70 g, 1.1 equivalents) and N, N-dimethylsulfamoyl chloride (2.1 ml, 1.1 equivalents) ) in dichloromethane (40 ml) as stated in Preparation 63 to provide 3.60 mg of a dark oil. This material was purified via chromatography on silica gel eluting with a gradient solvent of hexane / ethyl acetate 9: 1 to hexane / ethyl acetate 7: 3 to provide 1.0 gm. of a white solid, m.p. 79-81 ° (50%). Mass Spectrum Desorption Field: M + = 288.

Preparation 84 N, N-2- (4-aminophenyl) propyl N, N-dimethylsulfamide The nitrosulfamide from Preparation 83 (1.0 g, 3.5 'mmol) was treated with 5% Pd / C (2.0 g, excess) and hydrogen in ethyl acetate (100 ml) as described in Preparation 64 to provide 820 mg of a white solid, mp 101.5 ° -103 ° C (91%). Mass Spectrum Desorption Field: M + = 258.

Preparation 85 4-bromophenylacetyl chloride A solution of 50.0 g (232 mmol) of 4-bromophenylacetic acid in 150 mL of thionyl chloride was stirred at room temperature for 18 hours. The mixture was concentrated in vacuo to provide 54 g (100%) of the title compound.

Preparation '86 (R) - (-) -4-Benzyl-3- (4-bromophenylacetyl) -2-oxazolidinone A solution of 20.0 g (117 mmol) of (R) - (+) - 4-benzyl-2-oxazolidinone in 300 mL of tetrahydrofuran was cooled to 78 ° C and 73.0 mL (117 mmol) of n-Butyllithium 1.6 M was added. added in drop form. The mixture was stirred 30 minutes, then slowly added via cannula to a solution of 25 g (107 mmol) of material. from Preparation 85 in 150 mL of tetrahydrofuran at -78 ° C. The mixture was stirred for 1 hour and then 300 mL of 10% aqueous sodium bisulfate was added. The organic layer was separated and the aqueous layer was extracted three times with 100 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (750 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 24.7 g (68%) of the title compound. Analysis calculated for C? 8H16BrN03:% C, 57.77; % H, 4.31; % N, 3.74. Found:% C, 57.62; % H, 4.21; % N, 3.74. Mass Spectrum Desorption Field: M = 374 [a] D20 = -59.83 (c = 1.04, CIIC13).

Preparation 87 (-) -4í? -Benzyl-3- (2R- (4-bromophenyl) propionyl) -2- oxazoiidinone A solution of 48 g (128 mmol) of material from Preparation 86 in 200 mL of tetrahydrofuran was cooled to -78 ° C and 141 mL (141 mmol) of 1M sodium bis (trimethylsilyl) amide was added dropwise. The mixture was stirred 60 minutes then a solution of 20 g (141 mmol) of iodomethane in 20 mL of tratranidrofuran was slowly added. The mixture was stirred for 60 minutes at -78 ° C and then allowed to warm to room temperature for 60 minutes. To the reaction was added 10% aqueous sodium bisulfite and the organic layer was separated and the aqueous layer was extracted three times with 100 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (500 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 28.7 g (58%) of the title compound. Analysis calculated for C? 9H? 8BrN03:% C, 58.78; % H, 4.67; % N, 3.61. Found:% C, 58.81; % II, 4.63; % N, 3.54. Mass Spectrum Desorption Field: M = 388. [a] D20 = -110.4 (c = 0.96, CHC13).

Preparation 88 (R) - (+) -2- (4-bromophenyl) -propanol A solution of 28.7 g (74 mmol) of the material of Preparation 87 in 250 mL of ether was cooled to 0 ° C and 74 mL (148 mmol) of 2M lithium borohydride in tetrahydrofuran was added dropwise. The mixture was stirred for 2 hours, then 1N sodium hydroxide was added and the mixture was stirred until either the organic or aqueous layer was rinsed. The organic layer was separated and the aqueous layer was extracted three times with 10 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (800 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 12.3 g (79%) of the title compound. Analysis calculated for C9HuBrO; % C, 50.26:% H, 5.15. Found:% C, 48.96; % II, 4.91 Desorption Field of Mass Spectrum: M + 1 = 216 [a] D20 = +13.79 (c = 1.06, CHC13).

Preparation 89 (R) -2- (4-bromophenyl) propyl methanesulfonate A solution of 12.2 g (56.7 mmol) of material from Preparation 88 and 8.7 mL (62.4 mmol) of triethylamine in 180 mL of dichloromethane was cooled to 0 ° C. A solution of 4.8 mL (62.4 mmol) of methanesulfonyl chloride in 10 mL of dichloromethane was added dropwise. The cold bath was removed and the mixture was stirred at room temperature for 2 hours. The mixture was washed with 200 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 60 mL of ether. The combined organics were dried (MgSO), filtered and concentrated in vacuo, providing 15.9 g (96%) of the title compound.

Preparation 90 Azide of (R) -2- (4-bromophenyl) propyl A solution of 15.8 g (54 mmol) of material from Preparation 89 in 180 mL of N, N-dimethylformamide and 7.0 g (108 mmol) of sodium azide was heated at 80 ° C for 15 hours. The mixture was cooled and concentrated in vacuo. The residue was divided between 100 mL of water and 100 mL of ether. The organic layer was separated and the aqueous layer was washed three times with 30 mL each of ether. The combined organic extracts were dried (MgSO 4), filtered and concentrated in vacuo to give 12.13 g (94%) of the title compound.

Preparation 91 (R) - (+) -2- (4-bromophenyl) propylamine hydrochloride A solution of 12.2 g (50.4 mmol) of material from Preparation 90 in 168 mL of tetrahydrofuran and 3.6 mL of water was stirred at room temperature for 18 hours. The mixture was diluted with 100 mL of ether and 50 mL of brine. The organic layer was dried (MgSO 4), filtered and concentrated in vacuo. The residue was dissolved in 100 mL of ether and 200 mL of ether saturated with hydrochloric acid was added thereto. Filtration of the resulting solid afforded 11.9 g (94%) of the title compound. Analysis calculated for C9II13 BrClN:% C, 43.14; % II, 5.23; % N, 5.59. Found:% C, 43.44; % H, 5.23; % N, 5.56. Mass spectrum: [M-HC1] = 214. [a] u = +24. 06 (c = 1. 00, H20) Preparation 92 (R) -2- (4-bromophenyl) -N- (t-butoxycarbonyl) propylamine To a solution of 5.0 g (20.0 mmol) of the material of Preparation 91 in 30 mL of chloroform and 30 mL of saturated sodium bicarbonate was added 4.3 g (20.0 mmol) of di-tert-butyl dicarbonate. The solution was stirred at room temperature for 18 hours. The organic layer was separated and the aqueous layer was extracted three times with 10 mL each of chloroform. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to provide 6.2 g (100%) of the title compound.

Preparation 93 (S) - (+) -4-Benzyl-3- (4-bromophenylacetyl) -2-oxazolidinone Following the procedure of Preparation 86 and using (S) - (-) -4-benzyl-2-oxazolidinone in place of (R) - (+) - 4-benzyl-2-oxazolidinone, 25.3 g (63%) was provided. of the title compound. Analysis calculated for C18H? 6BrN03:% C, 57. 77:% H, 4. 31; % N, 3.74: Found:% C, 57.69; % H, 4.18; % N, 3.82. Mass Spectrum Desorption Field: M = 374. [a] D20 = +59. 35 (c = 1. 04, CHC13).

Preparation 94 ; +) -4S-Benzyl-3- (25- (4-bromophenyl) propionyl) -2- oxazolidinone Following the procedure of Preparation 87 and using material from Preparation 93 in place of the material of Preparation 86, 28.9 g (51%) of the title compound was provided. Analysis calculated for C? 9I? 8BrN03:% C, 58.78; % II, 4.67; % N, 3.61. Found:% C, 59.40; % H, 4.61; % N, 3.64. Mass Spectrum Desorption Field: M = 388. [a] D20 = +114.8 (c = 1.01, CHC13).

Preparation 95 (S) - (-) -2- (4-bromophenyl) propanol Following the procedure of Preparation 88 and using the material of Preparation 94 instead of the material of Preparation 87, 12.3 g (79%) of the title compound was provided. Analysis calculated for CgHuBrO:% C, 50.26; % H, 5.15. Found:% C, 50.38; % H, 5.08. Mass Spectrum Desorption Field: M + 1 = 216. [a] D20 = -13.25 (c = 1.0, CHC13).

Preparation 96 (S) -2- (4-bromophenyl) propylmethanesulfonate Following the procedure of Preparation 89 and using the material of Preparation 95 in place of the material of Preparation 88, 16.9 g (100%) of the title compound was provided.

Preparation 97 (S) -2- (4-bromophenyl) propylazide Following the procedure of Preparation 90 and using the material of Preparation 96 instead of the material of Preparation 89, 13.0 g (94%) of the title compound was provided.

Preparation 98 (S) - (-) -2- (4-bromophenyl) propylamine hydrochloride Following the procedure of Preparation 91 and using the material of Preparation 97 instead of the material of Preparation 90, 11.6 g (86%) of the title compound was provided. Analysis calculated for C9II? 3BrClN:% C, 43.14; % II, 5.23; % N, 5.59. Found:% C, 43.36; % H. 5.39; % N, 5.64 Mass spectrum: [M-HC1] = 214 [a] D20 = -25.3 (c = 1.02, H20).

Preparation 99 (S) -2- (4-bromophenyl) -N- (t-butoxycarbonyl) propylamine Following the procedure of Preparation 92 and using the material of Preparation 98 instead of the material of Preparation 91, 5.9 g, (94%) of the title compound was provided.

Preparation 100 (R) -2- (4- (3-thienyl) phenyl) -N- (t-butoxycarbonyl) propylamine To a solution of 2.0 g (6.4 mmol) of material from Preparation 92, 0.9 g (7.0 mmol) of thiophene-3-boronic acid and 1.3 g (9.6 mmol) of potassium carbonate in 20 mL of dioxane and 5 mL of water, 0.4 g (0.32 mmol) of tetrakis (triphenylphosphamine) palladium (0) was added. The mixture was heated at 100 ° C for 18 hours. The mixture was cooled to room temperature and 20 mL of water and 20 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 10 ml each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (150 g of silica gel, 15% ethyl acetate / hexane) of the residue afforded 1.4 g (70%) of the title compound.

Preparation 101 (S) -2- (4- (3-thienyl) phenyl) -N- (t-butoxycarbonyl) propylamine Following the preparation procedure 100 and using the material of Preparation 99 instead of the material of Preparation 92, 5.9 g (94%) of the title compound was provided.

Preparation 102 2R- (4- (3-thienyl) phenyl) propylamine A solution of 1.4 g of the material of Preparation 100 in 15 mL of 25% trifluoroacetic acid / dichloromethane was stirred at room temperature for 3 hours. The mixture was concentrated in vacuo and the residue was dissolved in 20 mL of 1N sodium hydroxide and 20 L of ethyl acetate. The organic layer was separated and the aqueous layer was extracted four times with 10 mL each of ethyl acetate. The organic layer was separated and the aqueous layer was extracted four times with 10 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to give 0.85 g (89%) of the title compound.

Preparation 103 - (4- (3-thienyl) phenyl) propylamine Following the procedure of Preparation 102 and using the material of Preparation 101 in place of the material of Preparation 100, 0.9 g (94%) of the title compound was provided.

EXAMPLE 1 N-2- (4-Bromophenyl) propylmethanesulfonamide To a solution of 2.8 g (11.3 mmol) of the material of Preparation 2 at room temperature in 30 mL of dichloromethane and 30 mL of 10% aqueous sodium hydroxide was added 1.1 mL (13.6 mmol) of methanesulfonyl chloride. After 1 hour an additional 1.1 mL (13.6 mmol) of methanesulfonyl chloride was added and stirring continued for 1.5 hours. The organic portion was separated and the aqueous portion was extracted twice with 25 mL each of dichloromethane. The combined organics were washed once with 25 mL of 10% aqueous sodium bisulfate, dried (Na2SO4), filtered and concentrated in vacuo to provide 2.7 g (81%) of the title compound. Analysis calculated for C? 0H? NBrO2S:% C, 41.11; % H, 4.83; % N, 4.79. Found:% C, 40.92; % H, 4.78; % N, 4.85. Mass Spectrum Desorption Field: M -1 = 291.

EXAMPLE 2 N-2- (4- (3-fluorophenyl) phenyl) propylmethanesulfonamide To a degassed or gas-free solution of 1.5 g (5.1 mmol) of material from Example 1, 1.1 g (7.7 mmol) of 3-fluorobenzeneboronic acid and 1.1 g (7.7 mmol) of potassium carbonate in 30 mL of toluene were added. added 0.2 g (0.3 mmol) of bis (triphenylphosphamine) palladium (II) dichloride. The mixture was heated at 100 ° C for 16 hours, cooled to room temperature and diluted with 20 mL of ethyl acetate. The mixture was washed once with 25 mL of water and the organic portion was separated. The aqueous portion was extracted three times with ethyl acetate and the combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography on 75 g of silica gel (20% ethyl acetate / toluene) followed by recrystallization from ethyl ether, filtration and drying in vacuo at 60 ° C, afforded 0.15 g (9%) of the title compound. Analysis calculated for C? 6H18NF2S »0.25H20:% C, 61.62; % H, 5.98; % N, 4.49. Found:% C, 61.67; % H, 5.83; % N, 4.64. Mass Spectrum Desorption Field: M = 307 EXAMPLE 3 N-2- (4- (3-formylphenyl) phenyl) propylmethanesulfonamide To a degassed solution of 1.5 g (5.1 mmol) of the material of Example 1, 1.2 g (8.1 mmol) of 3-formylbenzeneboronic acid and 1.1 g (8.1 mmol) of potassium carbonate in 30 mL of toluene, 0.3 g ( 0.3 mmol) of tetrakis- (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 16 hours after which, 5 mL of water was added and the heating continued for 1 hour. The mixture was then cooled to room temperature and 10 mL of water was added. The organic portion was separated and the aqueous portion was extracted twice with ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography on 50 g of silica gel (40% ethyl acetate / hexane) gave 0.7 g (41%) of the title compound. Analysis calculated for Ci7H? GN03S:% C, 64.33; % H, 6.03; % N, 4.41. Found:% C, 64.33; % H, 6.06; % N, 4.01 Mass Spectrum Desorption Field: M = 317.

EXAMPLE 4 N-2- (4- (4-formylphenyl) phenyl) propylmethanesulfonamide To a degassed or gas-free solution of 1.5 g (5.1 mmol) of material from Example 1, 1.2 g (8.1 mmol) of 4-formiibencenboronic acid and 1.1 g (8.1 mmol) of potassium carbonate in 30 mL of toluene were added. added 0.3 g (0.3 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 4 hours, after which 0.3 g (2.0 mmol) of 4-formylbenzeneboronic acid and 0.1 g (0.09 mmol) of tetrakis (triphenylphosphamine) -palladium (0) were added and the heating continued. for 16 hours. To this solution, 5 mL of water was added and the heating continued for 1 hour. The mixture was then cooled to room temperature and 10 mL of water was added. The organic portion was separated and the aqueous portion was extracted twice with ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography on 50 g of silica gel (50% ethyl acetate / hexane) provided a solid which was recrystallized from bromobutane / ethyl acetate, filtered and dried in vacuo at 60 ° C, to give 0.5 g (32%) ) of the title compound.

Analysis calculated for C? 7H? 9N03S:% C, 64.33; % H, 6.03; % N, 4.41. Found:% C, -64.62; % H, 5.97; % N, 4.36. Mass Spectrum Desorption Field: M = 317.

EXAMPLE 5 N-2- (4- (3-thienyl) phenyl) -propylmethanesulfonamide To a degassed or gas-free solution of 1.5 g (5.1 mmol) of material from Example 1, 1.0 g (7.7 mmol) of thiophene-3-boronic acid and 1.1 g (7.7 mmol) of potassium carbonate in 30 mL of toluene , 0.3 g (0.3 mmol) of tetrakis- (triphenylphosphamine) palladium (0) was added. The mixture was heated at 100 ° C for 4 hours, cooled to room temperature and diluted with 20 mL of ethyl acetate. The mixture was then washed once with water, and the organic portion was separated. The aqueous portion was extracted twice with ethyl acetate and the combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography on 50 g of silica gel (35% ethyl acetate / hexane) provided a solid which was recrystallized from bromobutane, filtered and dried in vacuo at 60 ° C to provide 0.4 g (27%) of the title compound .

Analysis calculated for C? 4H? 7N02S2:% C, 56.92; % H, 5.80; % N, 4.74. Found:% C, 57.00; % H, 5.92; % N, 4.98 Mass Spectrum Desorption Field: M = 295.

EXAMPLE 6 N-2- (4- (2-methoxyphenyl) phenyl) propylmethanesulfonamide To a degassed or gas-free solution of 1.0 g (3.4 mmol) of material from Example 1, 0.8 g (5.1 mmol) of 2-methoxybenzeneboronic acid and 0.7 g (5.1 mmol) of potassium carbonate in 15 mL of dioxane were added. added 0.2 g (0.2 mmol) of tetrakis- (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 16 hours. The reaction mixture was cooled to room temperature and diluted with 10 mL of water and extracted three times with ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography on 50 g of silica gel (35% ethyl acetate / hexane) gave 1.0 g (90%) of the title compound as a viscous oil. Analysis calculated for C? 7H2? N03S:% C, 63.92; % H, 6.62; % N, 4.39. Found:% C, 63.68; % H, 6.78; % N, 4.23 Mass Spectrum Desorption Field: M = 319.

EXAMPLE 7 N-2- (4- (2-fluorophenyl) phenyl) ethyl) 2-propanesulfonamide A. (2- (4-bromophenyl) -N- (t-butoxycarbonyl) ethylamine: To a solution of 10.0 g (50.0 mmol) of 4-bromophenethylamine in 100 mL of chloroform and 100 mL of saturated sodium bicarbonate was added 11.0 g (50.0 mmol) of di-tert-butyl dicarbonate The solution was stirred at room temperature for 1 hour, the organic layer was separated and the aqueous layer was extracted three times with 30 mL each of chloroform. dried (MgSO 4), filtered and concentrated in vacuo to provide 15 g (100%) of the title compound.

B. 2- (4- (2-flurophenyl) phenyl) -N- (t-butoxycarbonyl) -phenylethylamine: To a degassed or gas-free solution of 7.9 g (26.2 mmol) of material from Step A, 5.5 g ( 39.3 mmol) of material from Preparation 3 and 5.4 g (39.3 mmol) of potassium carbonate in 90 mL of toluene was added 1.5 g. (1.3 mmol) of tetrakis- (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 3 hours. The mixture was cooled to room temperature and 90 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 30 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (400 g of silica gel, 15% ethyl acetate / hexane) of the residue afforded 7.1 g of the material which was triturated in hexane to give 3.5 g (42%) of the title compound.

C. 2- (4 '- (2-fluorobiphenyl)) ethylamine: A solution of 3.5 g of the material from Step B in 40 mL of 20% trifluoroacetic acid / dichloromethane was stirred at room temperature for 1 hour. The mixture was concentrated in vacuo to provide 3.9 g (100%) of the title compound.

D. A solution of 1.0 g (3.0 mmol) of material from Step C and 1 mL (7.6 mmol) of triethylamine in 10 mL of dichloromethane was cooled to 0 ° C. A solution of 0.33 mL (3.0 mmol) of isopropylsulfonyl chloride in 5 L of dichloromethane was added as drops. The cold bath was stirred and the mixture was stirred at room temperature for 1 hour. The mixture was diluted with 10 mL of ether and washed with 20 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 10 mL each of ether. The combined organics were dried (MgSO4), filtered and concentrated in vacuo to give 0.5 g (52%) of the title compound. Analysis calculated for C? 7H20FNO2S »0.25 H20:% C, 62.65; % H, 6.34; % N, 4.30. Found:% C, 62.62; % H, 6.15; % N, 4.49. Mass Spectrum Desorption Field: M = 321.

EXAMPLE 8 N-2- (4- (2-fluorophenyl) phenyl) propyl) etensulfonamide A solution of 1.0 g (4.4 mmol) of the material of Preparation 6 and 0.67 mL (4.8 mmol) of triethylamine in 15 mL of dichloromethane was cooled to 0 ° C. A solution of 0.46 mL (4.4 mmol) of 2-chloro-1-ethanesulfonyl chloride in 2 mL of dichloromethane was added dropwise. The cold bath was stirred and the mixture was stirred at room temperature for 1 hour. The mixture was diluted with 15 ml of ether and washed with 15 ml of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 5 ml each of ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 30% ethyl acetate / hexane) of the residue afforded 0.6 g (43%) of the title compound.

Analysis calculated for C? 7H18FN02S:% C, 63.93; % H, 5.68; % N, 4.39. Found:% C, 63.98; % H, 5.58; % N, 4.42. Mass Spectrum Desorption Field: M = 319.

EXAMPLE 9 N-2- (4- (2-fluorophenyl) phenyl) propylethanesulfonamide A solution of 0.2 g (0.80 mmol) of material from Preparation 6 and 0.13 mL (0.95 mmol) of triethylamine in 5 mL of dichloromethane was cooled to 0 ° C. A solution of 0.076 mL (0.80 mmol) of ethanesulfonyl chloride in 1 mL of dichloromethane was added dropwise. The cold bath was stirred and the mixture was stirred at room temperature for 16 hours. The mixture was washed with 5 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted once with 5 mL of dichloromethane. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.20 g (78%) of the title compound. Analysis calculated for C? 7H20FN02S:% C, 63.53; % H, 6.27; % N, 4.36. Found:% C, 63.24; % H, 6.27; % N, 4.39.

Mass Spectrum Desorption Field: M = 321 EXAMPLE 10 N-2- (4- (2-fluorophenyl) phenyl) propyl 2-propanesulfonamide A solution of 0.2 g (0.80 mmol) of material from Preparation 6 and 0.13 mL (0.95 mmol) of triethylamine in 5 mL of dichloromethane was cooled to 0 ° C. A solution of 0.090 mL (0.80 mmol) of isopropylsulfonyl chloride in 1 mL of dichloromethane was added dropwise. The cold bath was removed and the mixture was stirred at room temperature for 16 hours. The mixture was washed with 5 ml of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted once with 5 ml of dichloromethane. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue gave 0.040 g (15%) of the title compound. Analysis calculated for C? 8H22FN02S:% C, 64.45; % H, 6.61; % N, 4.81. Found:% C, 64.2; % II, 6.51; % N, 4.02. Mass Spectrum Desorption Field: M = 335.

EXAMPLE 11 N ', N'-dimethylsulfamide of N-2- (4- (2-fluorophenyl) phenyl) propyl A solution of 0.2 g (0.80 mmol) of material from Preparation 6 and 0.13 mL (0.95 mmol) of triethylamine in 5 mL of dichloromethane was cooled to 0 ° C. A solution of 0.086 mL (0.80 mmol) of dimethylsulfamoyl chloride in 1 mL of dichloromethane was added dropwise. The cold bath was removed and the mixture was stirred at room temperature for 16 hours. The mixture was washed with 5 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted once with 5 mL of dichloromethane. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.20 g (74%) of the title compound. Analysis calculated for C? 7H21FN202S:% C, 60.69; % H, 6.29; % N, 8.33. Found:% C, 60.42; % II, 6.23; % N, 8.06. Mass Spectrum Desorption Field: M = 336 EXAMPLE 12 N-2- (4-isopropyl) phenyl) propyltrifluoromethanesulfonamide A suspension of the product from Preparation 8, 0.30 g (1.40 mmol) in dichloromethane (20 ml) was cooled to 0 ° C. Triethylamine 0.59 ml (4.21 mmol) was added to the suspension, followed by 0.16 ml trifluoromethanesulfonyl chloride (1.54 mmol). The solution was stirred at 0 ° C for thirty minutes then it was warmed to room temperature. The progress of the reaction was monitored by thin layer chromatography. After consumption of the starting material, the reaction mixture was divided between water and dichloromethane. The organic fraction was washed with 0.2 M hydrochloric acid, brine, dried (MgSO) and concentrated in vacuo. Chromatography (SiO2, 30% ethyl acetate / hexanes) gave 0.35 g (81%) of the title compound. Mass Spectrum Desorption Field: M = 309 Analysis for C? 3II? 8F3N? 3S: Theory: C, 50.48; H, 5.86; N, 4.53 Found: C, 50.40; H, 5.78; N, 4.74 EXAMPLE 13 N-2- (4-isopropylphenyl) propyl 2-propanesulfonamide A suspension of the product from Preparation 8, 0.30 g, (1.40 mmol) in dichloromethane (20 ml) was cooled to 0 ° C. Triethylamine 0.59 ml (4.21 mmol) was added to the suspension followed by isopropylsulfonyl chloride (0.16 ml, 1.54 mmol). The solution was stirred at 0 ° C for thirty minutes then it was warmed to room temperature. The progress of the reaction was monitored by thin layer chromatography. After consumption of the starting material, the reaction mixture was divided between water and dichloromethane. The organic fraction was washed with 0.2 M hydrochloric acid, brine, dried (MgSO) and concentrated in vacuo. Chromatography (SiO2, 30% ethyl acetate / hexanes) gave the title compound 0.35 g (81%). Field of Mass Spectrum Desorption: M = 283. Analysis for C? 3II18F3N03 ?: Theory; C, 63.57; H, 8.89; N, 4.94 Found: C, 63.63; H, 8.90; N, 5.18 EXAMPLE 14 N-2- (4-methoxyphenyl) propyltrifluoromethanesulfonamide A suspension of the product of Preparation 10, 1.00 g, (4.96 mmol) in dichloromethane (50 ml) was cooled to 0 ° C. Triethylamine 2.09 ml (14.9 mmol) was added to the suspension followed by 0.58 ml trifluoromethanesulfonyl chloride (5.45 mmol). The solution was stirred at 0 ° C for thirty minutes then it was warmed to room temperature. The progress of the reaction was monitored by thin layer chromatography. After consumption of the starting material, the reaction mixture was divided between water and dichloromethane. The organic fraction was washed with 0.2 M hydrochloric acid, brine, dried (MgSO4) and concentrated in vacuo. Chromatography (Si02, 30% ethyl acetate / hexanes) gave the title compound 1.07 g (73%). Mass Spectrum Desorption Field: M = 297. Analysis for C? II? F3N03S: Theory; C, 44.44; H, 4.75; N, 4.77 Found: C, 44.54; H, 4.55; N, 4.80 EXAMPLE 15 N-2- (4-cyclopentylphenyl) propylmethanesulfonamide Condition 1: The product of Example 1, 0.50 g (1.71 mmol) was dissolved in anhydrous tetrahydrofuran (5 ml) under a nitrogen atmosphere. To this was added tetrakis (triphenylphosphamine) palladium (O) (0.099 g, 0.086 mmol) followed by magnesium bromide cyclopentyl (2 M in diethyl ether, 2.14 ml, 4.28 mmol). The solution was heated to reflux for 16 hours. After cooling, the reaction was partitioned between water and diethyl ether. The aqueous layer was extracted again with diethyl ether twice, and the organic fractions were combined. The organic layers were washed with brine, dried (MgSO 4) and concentrated in vacuo. Chromatography (SiO2, 30% ethyl acetate / hexanes) gave the title compound 0.06 g (13%). Mass Spectrum Desorption Field: M = 281. Analysis for C? 5H23N02S: Theory: C, 64.02; H, 8.24; N, 4.98 Found: C, 64.30; H, 8.35; N, 4.84.

Condition 2: It has subsequently been discovered that the optimum conditions for the above reaction are as follows: The bromide was dissolved in diethyl ether and cooled to -78 ° C. Added [1,1'-bis (diphenylphosphamine) ferrocene] dichloro-palladium (ii) (PdCl2) (dppf)) followed by the appropriate magnesium alkyl reagent. The solution was stirred for one hour and then allowed to warm to room temperature for 2 hours. The survey is the same as in condition i described above.

EXAMPLE 16 N-2- (4-t-butylphenyl) propylmethanesulfonamide 65 mg (0.57 mmol) of methanesulfonyl chloride in dichloromethane (5 mL) was added dropwise to a solution of 100 mg (0.52 mmol) of the product of Preparation 23 and 60 mg (0.59 mmol) of triethylamine in dichloromethane ( 15 mL) at room temperature under N2. The reaction mixture was stirred for 16 hours at room temperature. The mixture was then concentrated under reduced pressure and the resulting semi-solid was taken up in 25 mL of ethyl acetate, washed once with 25 mL of H20, dried over K2CO3, and concentrated under reduced pressure. Recrystallization from hexane / ethyl acetate 9: 1 afforded the title compound 65 mg (46%) as white crystals. Analysis calculated for C? 4II23N02S:% C, 62.42; % II, 8.61; % N, 5.20. Found% C 62.64; % H, 8.41; % N, 5.19. Mass spectrum: M = 269.

EXAMPLE 17 N-2- (4-t-butylphenyl) propyltrifluoromethanesulfonamide The title compound 70 mg (29%) was prepared as an oil following the method of Example 16, starting from the product of Preparation 23 and using trifluoromethanesulfonyl chloride. Analysis calculated for C? 4p20NO2SF3:% C, 52.00; % II, 6.23; % N, 4.33. Found% C, 51.79; % H, 6.20; % N, 4.27. Mass Spectrum: M = 323 EXAMPLE 18 N-2- (4-t-butylphenyl) butylmethanesulfonamide The title compound, 140 mg (67%) was prepared as an oil following the method of Example 16, starting from the product of Preparation 24. The purification was performed by chromatography on silica gel (chromatotron-100 micron rotor) eluting with a hexane / ethyl acetate solvent 3: 1. Analysis calculated for C? 5H25N02S:% C, 63.57; % H, 8.89; % N, 4.94. Found% C, 63.63,% H, 63.57; % H, 8.89; % N, 4.93. Mass spectrum: M = 283.

EXAMPLE 19 N-2- (4-t-butylphenyl) -2-methylpropyl trifluoromethanesulfonamide The title compound, 131 mg (40%) was prepared as a crystalline solid from hexane / ethyl acetate 19: 1 following the method of Example 16, starting from the product of Preparation 25 and using trifluoromethanesulfonyl chloride. Analysis calculated for C? 5H22N02SF3:% C, 53.40; % H, 6.57; % N, 4.15. Found% C, 53.75,% H, 6.40; % N, 4.02. Mass spectrum: M = 337.

EXAMPLE 20 N-2- (2-naphthyl) propyl trifluoromethanesulfonamide The title compound was prepared following the method of Example 16, starting from the product of Preparation 26. The purification was carried out by chromatography on silica gel (chromatotron-100 micron rotor) eluting with a hexane / ethyl acetate 19 solvent: 1 to provide the title compound 140 mg (44%) as a solid. Analysis calculated for C? H? 4N02SF3:% C, 52.99; % H, 4.45; % N, 4.41. Found% C, 52.90,% H, 4.42; % N, 4.32. Mass spectrum: M = 317.

EXAMPLE 21 N-2- (4-t-butylphenyl) butyl trifluoromethanesulfonamide The title compound was prepared following the method of Example 16, starting with the product of Preparation 24 and using trifluoromethanesulfonyl chloride. Purification was performed by chromatography on silica gel (chromatotron-100 micron rotor) eluting with a hexane / ethyl acetate solvent 19: 1 to give the title compound, 187 mg (57%) as an oil. Analysis calculated for C? 5II22N02SF3:% C, 53.56; % II, 6.31; % N, 4.12. Found% C, 53.40,% H, 6.57; % N, 4.15. Mass spectrum: M = 337.

EXAMPLE 22 2-propanesulfonamide of N-2- (4-t-butylphenyl) butyl The title compound was prepared following the method of Example 16, starting from the Product of Preparation 24 and using isopropylsulfonyl chloride. Purification was carried out by chromatography on silica gel (chromatotron-2000 micron rotor) eluting with a hexane / ethyl acetate 4: 1 gradient solvent to yield the title compound 73 mg (32%) as an oil. Analysis calculated for C? 7H29N02S:% C, 65.55; % H, 9.38; % N, 4.50. Found:% C, 64.65; % H, 8.96; % N, 4.60. Mass spectrum: M = 311.

EXAMPLE 23 N-2- (4-t-butylphenyl) propyl 2-propanesulfonamide The title compound was prepared following the method of Example 16, starting from the Product of Preparation 23 and using isopropylsulfonyl chloride. Purification was performed by chromatography on silica gel (chromatotron-2000 micron rotor) eluting with a hexane / ethyl acetate 4: 1 gradient solvent to yield the title compound 11 mg (29%). Analysis calculated for C? 6H27N02S:% C, 64.61; % H, 9.15; % N, 4.71. Found% C, 64.53,% H, 8.99; % N, 4.92. Mass spectrum: M = 297.

EXAMPLE 24 N-l- (4-t-butylphenyl) cyclopropylmethyl trifluoromethanesulfonamide 165 mg (0.98 mmol) of trifluoromethylsulfonyl chloride 100 mg (0.49 mmol) of the product of Preparation 30, and 100 mg (0.98 mmol) of triethylamine were combined in dichloromethane (15 mL) and reacted as described in Example 16 to provide 164 mg of an oil. This material was purified via chromatography on silica gel eluting with a gradient solvent of hexane to hexane / EtOAc 9: 1 to give 100 mg (61%) of the title compound as an oil that crystallizes slowly. p.f. 82-84 ° C, calculated for C15H2oN02SF3: Theory: C, 53.72; H, 6.01; N, 4.18. Found: C, 53.97; H, 6.12; N, 4.10. Mass spectrum: M = 335.

EXAMPLE 25 2-propanesulfonamide of N-l- (4-t-butylphenyl) cyclopropylmethyl 140 mg (0.98 mmol) of isopropylsulfonyl chloride, 100 mg (0.49 mmol) of the product of Preparation 30, and 100 mg (0.98 mmol) of triethylamine were combined in dichloromethane (15 mL) and reacted as described in Example 16 to provide 147 mg of an oil. This material was purified via chromatography on silica gel eluting with a gradient solvent of hexane to hexane / EtOAc 19: 1 to hexane / EtOAc 1: 1 to give the title compound 33 mg (22%) as an oil that crystallizes slowly . p.f. 87-89.5 ° C, Calculated for C? 7H27N02S: Theory: C, 65.98; H, 8.79; N, 4.53. Found: C, 65.78; H, 9.01; N, 4.35.

EXAMPLE 26 N-2- (4- (4-methylphenyl) phenyl) propylmethanesulfonamide To a degassed or gas-free solution of 1.4 g (4.7 mmol) of the product of Example 1, 1.0 g (7.1 mmol) of 4-methylbenzeneboronic acid, 1.0 g (7.1 mmol) of potassium carbonate in 30 mL of toluene, and 10 mL of water was added 0.3 g, (0.2 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 2 hours, cooled to room temperature and the organic portion separated. The aqueous portion was extracted three times with ethyl acetate and the combined organic portions were dried (MgSO4), filtered and concentrated in vacuo. The residue was chromatographed on silica gel (30% ethyl acetate / hexane) to give an off white solid. The solid was suspended in diethyl ether, filtered and dried in vacuo to give 0.6 g (43%) of the title compound. Analysis calculated for C? 7H2; LN02S:% C, 67.29; % H, 6.98; % N, 4.62. Found:% C, 66.98; % II, 6.96; % N, 4.63, Mass Spectrum Desorption Field: M = 307 EXAMPLE 27 N-2- (4-bromophenyl) propyl 2-propylsulfonamide To a suspension of 0.5 g (2.0 mmol) of the product of Preparation 31 in 5 mL of dichloromethane was added 0.6 mL (4.0 mmol) of triethylamine. The mixture was cooled to 0 ° C and 0.2 mL (2.0 mmol) of isopropylsulfonyl chloride was added. After stirring at 0 ° C for 20 minutes, the mixture was washed once with 10% aqueous sodium bisulfate and the organic layer was separated. The aqueous layer was extracted three times with dichloromethane. The combined organic portions were dried (Na2SO4), filtered and concentrated in vacuo. Chromatography on 50 g of silica gel (35% ethyl acetate / hexane) gave 0.2 g (25%) of the title compound. Analysis calculated for Ci2II? 8N02SBr:% C, 45.01; % II, 5.67; % N, 4.37. Found:% C, 45.30; % H, 5.92; % N, 4.43. Mass Spectrum Desorption Field: M + 1 = 321 EXAMPLE 28 N-2- (4- (3-thienyl) phenylpropyl 2-propanesulfonamide A. N-2- (4- (3-thienyl) phenyl) -Nt-butoxycarbonylpropylamine: To a degassed or gas-free solution of 8.2 g (26.0 mmol) of material of Preparation 4, 4.0 g (31.2 mmol) of Thiophene-3-boronic acid and 5.3 g (39.0 mmol) of potassium carbonate in 75 mL of dioxane and 25 mL of water were added 1.5 g (1.3 mmol) of tetrakis (triphenylphosphamine) palladium (O). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 200 mL of water and 100 L of ether were added. The organic layer was separated and the aqueous layer was extracted three times with ethyl acetate with 60 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (500 g of silica gel, 10% ethyl acetate / hexane) of the residue afforded 7.8 g (94%) of the title compound.

B. 2- (4- (3-Thienyl) phenyl) propylamine trifluoroacetic acid salt: A solution of 7.8 g (24.6 mmol) of the material from Step A in 80 mL of 20% trifluoroacetic acid / dicyoromethane was stirred at room temperature for 5 hours. The mixture was concentrated in vacuo to provide 8.1 g (100%) of the title compound.

C. A solution of 0.5 g (1.5 mmol) of the material from Step B and 0.52 mL (3.7 mmol) of triethylamine in 10 mL of dichloromethane was cooled to 0 ° C. A solution of 0.17 mL (1.5 mmol) of isopropylsulfonyl chloride in 1 mL of dichloromethane was added dropwise. The cold bath was stirred and the mixture was stirred at room temperature for 5 hours. The mixture was washed with 10 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 5 mL of dichloromethane. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.100 g (21%) of the title compound. Analysis calculated for C16H21N02S2:% C, 59.41; % H, 6.54; % M, 4.33. Found:% C, 59.34; % H, 6.34; % N, 4.29. Mass Spectrum Desorption Field: M = 323.

EXAMPLE 29 N-2- (4- (3-thienyl) phenylpropyl dimethylsulfonamide A. A solution of 0.5 g (1.5 mmol) of the material of Example 28, Step B and 0.52 mL (3.70 mmol) of triethylamine in 10 mL of dichloromethane was cooled to 0 ° C. A solution of 0.16 mL (1.5 mmol) of dimethylsulfamoyl chloride in 1 mL of dichloromethane was added dropwise. The cold bath was stirred and the mixture was stirred at room temperature for 5 hours. The mixture was washed with 10 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 5 mL of dichloromethane. The combined organics were dried (MgSO), filtered and concentrated in vacuo. The residue was suspended in 50% ether / hexane and filtered to provide 0.22 g (46%) of the title compound. Analysis calculated for C? 5II2oN202? 2:% C, 55.53; % II, 6.21; % N, 8.63. Found:% C, 55.51; % H, 6.21; % N, 8.39. Mass Spectrum Desorption Field: M = 324.

EXAMPLE 30 N-2- (4-methoxyphenyl) propyl 2-propanesulfonamide The title compound was prepared from the product of Preparation 10 as described in Example 13. Mass Spectrum Desorption Field: M = 271.4 Analysis for C? 3IÍ2? N03S: Theory: C, 56.71; H, 8.16; N, 4.86 Found: C, 57.54; H, 7.80; N, 5.16.

EXAMPLE 31 N-2- (4-methylphenyl) propyl 2-propanesulfonamide The title compound was prepared from the product of Preparation 33 as described in Example 13. Mass Spectrum Desorption Field: M = 255.2 Analysis for C? 3H2? N03S: Theory: C, 61.14; H, 8.29; N, 5.48 Found: C, 61.23; H, 8.35; N, 5.30.

EXAMPLE 32 N-2- (4-isopropylphenyl) propyl ethanesulfonamide The title compound was prepared from the product of Preparation 8 as described in Example 13, with the exception that the ethanesulfonyl chloride was used in place of isopropylsulfonyl chloride. Mass Spectrum Desorption Field: M = 269.1 Analysis for C? 4H23N? 3S: Theory: C, 62.42; H, 8.61; N, 5.20 Found: C, 62.68; H, 8.34; N, 5.11.

EXAMPLE 33 N-2- (4-isopropylphenyl) propyl dimethylsulfonamide The title compound was prepared from the product of Preparation 8 as described in Example 13, with the exception that dimethylsulfamoyl chloride was used in place of isopropylsulfonyl chloride. Mass Spectrum Desorption Field: M = 349.1 Analysis for C? 4H23N02S: Theory: C, 55.00; H, 6.35; N, 4.01 Found: C, 54.70; H, 6.12; N, 3.82.

EXAMPLE 34 N-2- (4-isobutylphenyl) propyl 2-propanesulfonamide The title compound was prepared from 2- (4-isobutylphenyl) propylamine hydrochloride as described in Example 13. Mass Spectrum Desorption Field: M = 297.2 Analysis for C16H27N02S: Theory: C, 64.61; H, 9.15; N, 4.71 Found: C, 64.84; H, 9.10; N, 4.74.

EXAMPLE 35 N-2- (4-cyclopentylphenyl) propyl 2-propanesulfonamide The title compound was prepared from ((4-bromo) -2-methylphenethyl) 2-propanesulfonamide as described in Example 15, Condition 2. Mass Spectrum Desorption Field: M = 309.3 Analysis for C? 7I27N02S: Theory: C, 65.98; H, 8.79; N, 4.53 Found: C, 66.21; H, 9.04; N, 4.54.

EXAMPLE 36 N-2- (4-cyclohexylphenyl) propyl 2-propanesulfonamide The title compound was prepared from the product of Example 27 as described in Example 15, Condition 2, with the exception that cyclohexylmagnesium chloride was used in place of cyclopentylmagnesium bromide. Mass Spectrum Desorption Field: M = 323.3 Analysis for C? 8H29N02S: Theory: C, 66.83; H, 9.04; N, 4.33 Found: C, 67.00; H, 9.18; N, 4.09.

EXAMPLE 37 N-2- (3-chloro-4- piperidinylphenyl) propyl 2-propanesulfonamide The title product was prepared from 2- (3-chloro-4-piperidinylphenyl) propylamine hydrochloride as described in Example 13.

Mass Spectrum Desorption Field: M = 358 .2 Analysis calculated for Ci7H27ClN202S: Theory: C, 56.89; H, 7.58; N, 7 80. Found: C, 57.19; H, 7.68; N, 8.02 EXAMPLE 38 N-2 (-) - (4-piperidinylphenyl) propyl 2-propanesulfonamide The title product was prepared from (-) -2- (4-piperidinylphenyl) propylamine hydrochloride (Synthesis, 6, 447, 1991) as described in Example 13. Mass Spectrum Desorption Field: M = 324.2 Analysis for C? 7II28N202S: Theory: C, 62.93; H, 8.70; N, 8.63. Found: C, 63.22; H, 8.51; N, 8.49.

F EXAMPLE 39 2-propanesulfonamide of N-2 - (+) - ((4-piperidinylphenyl) propyl) The title product was prepared from (+) -2- (4-piperidinylphenyl) propylamine hydrochloride (Synthesis 6, 447, 1991) as described in Example 13. 10 Mass Spectrum Desorption Field: M = 324.2 Analysis for Ci7lI28 202S: Theory: C, 62.93; H, 8.70; N, 8.63. Found: C, 62.68; H, 8.45; N, 8.72 EXAMPLE 40 N-2- (4-benzyloxyphenyl) propyl 2-propanesulfonamide The title compound was prepared from the product of Preparation 35 as described in Example 13. Mass Spectrum Desorption Field: M = 347. 2 25 Analysis for C? 9H25N03S: Theory: C, 65.68; H, 7.25; N, 4.03 Found: -C, 65.63; H, 7.31; N, 4.07 EXAMPLE 41 2-Propanesulfonamide of N-2- (4-isopropoxyphenyl) propyl The product from Preparation 36 (0.14 g, 0.40 mmol) was dissolved in dimethylformamide and sodium hydride (0.018 g, 0.44 mmol) was added. After 10 minutes, 2-bromopropane (0.054 g, 0.44 mmol) was added and the reaction was stirred at room temperature for 2 hours. The reaction mixture was partitioned between diethyl ether and water. The organic fraction was washed with brine, dried over magnesium sulfate and concentrated in vacuo. Chromatography (Si02, 20% ethyl acetate / hexanes) gave 0.11 g (70%) of the alkylated material. This material was dissolved in dichloromethane and treated with trifluoroacetic acid at room temperature. The reaction was washed with water, brine, dried over magnesium sulfate and concentrated in vacuo to provide 0.083 g of the title product. Mass Spectrum Desorption Field: M = 299.0 Analysis for C15H25NO3S: Theory: C, 60.17; H, 8.42; N, 4.68 Found: C, 58.57; H, 8.40; N, 4.31 EXAMPLE 42 2-methanesulfonamide of N-2- (4- (2-fluorophenyl) phenyl) propyl A solution of 1.6 g (6.5 mmol) of the material of Preparation 6 and 1.2 mL (7.1 mmol) of N, N-diisopropylethylamine in 20 mL of dichloromethane was cooled to 0 ° C. A solution of 0.51 mL (6.5 mmol) of methanesulfonyl chloride in 1 mL of dichloromethane was added dropwise. The cold bath was stirred and the mixture was stirred at room temperature for 1 hour. The mixture was washed with 20 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 5 mL of dichloromethane / ether 1: 1. The combined organics were dried (MgSO), filtered and concentrated in vacuo to provide 1.9 g (100%) of the title compound. Mass Spectrum Desorption Field: M = 307 Analysis for C? 6H? 8FN02S: Theory: C, 62.52; H, 5.90; N, 4.56 Found: C, 64.41; H, 5.99; N, 4.67 EXAMPLE 43 2-methanesulfonamide of N-l-methyl-2- (4-bromophenyl) ethyl A solution of 3.0 g (14.0 mmol) of the product of Preparation 38 and 2.1 mL (15.4 mmol) of triethylamine in 50 mL of dichloromethane was cooled to 0 ° C. A solution of 1.1 mL (14.0 mmol) of methanesuiphenyl chloride in 2 mL of dichloromethane was added dropwise. The mixture was then stirred at 0 ° C for 1 hour. The mixture was then washed with 50 mL of 10% aqueous sodium bisulfite, the organic layer was separated and the aqueous layer extracted three times with 20 mL of diethyl ether. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (100 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 1.5 g (37%) of the title compound.

EXAMPLE 44 2-methanesulfonamide of N-l-methyl-2- (4- (2-fluorophenyl) phenyl) ethyl To a degassed or gas-free solution of 1.5 g (5.1 mmol) of the product of Example 43, 1.1 g (7.7 mmol) of the product of Preparation 3 and 1.1 g (7.7 mmol) of potassium carbonate in 20 mL of toluene was added 0.3 g. (0.2 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. It was then cooled to room temperature and 20 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 10 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. The residue was suspended in diethyl ether and filtered to provide 0.673 g (43%) of the title compound. Mass Spectrum Desorption Field: M = 307 Analysis for C? 6H? 8FN02S: Theory: C, 62.52; II, 5.90; N, 4.56 Found: C, 62.26; H, 5.92; N, 4.49.

EXAMPLE 45 N-2- (4- (4-formylphenyl) phenyl) propyl 2-propanesulfonamide A degassed or gas-free solution of 2.4 g (7.5 mmol) of the material of Preparation 39, 1.7 g (11.2 mmol) of 4-formylphenylboronic acid, 1.6 g (11.2 mmol) of potassium carbonate and 0.4 g (0.4 mmol) of tetrakis (triphenylphosphamine) palladium (0) in 33 mL of dioxane and 11 mL of water were heated at 100 ° C overnight. The mixture was cooled to room temperature, it was diluted with 20 mL of water, and extracted three times with 50 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (175 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 1.8 g (71%) of the title compound. Analysis calculated for C19H23N03S:% C, 66.06% H, 6.71; % N, 4.05. Found:% C, 66.23; % H, 6.69; % N, 4.11. Mass Spectrum Desorption Field: M = 345 EXAMPLE 46 2-propanesulfonamide of N-2- (4- (4- (hydroxymethyl) phenyl) phenyl) propyl A solution of 0.5 g (1.45 mmol) of the material of Example 45 and 0.055 g (1.45 mmol) of sodium borohydride in 5 mL of ethanol was stirred overnight at room temperature, then concentrated in vacuo. The residue was partitioned between 25 mL of water and 25 L of ethyl acetate, the organic layer was separated and the aqueous layer was extracted three more times with 25 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 60% ethyl acetate / hexane) of the residue afforded 1.8 g (71%) of the title compound. Analysis calculated for C19H25N03S:% C, 65.68; % H, 7.25; % N, 4.03. Found:% C, 65.40; % H, 7.40; % N, 4.02. Mass Spectrum Desorption Field: M = 347 EXAMPLE 47 N-2- (4- (2-formylphenyl) phenyl) propyl 2-propanesulfonamide Prepared as in Example 45, using 8.1 g (25.1 mmol) of material from Preparation 39, 4.7 g (31.4 mmol) of 2-formylphenylboronic acid, 5.2 g (37.3 mmol) of potassium carbonate and 1.5 g (1.3 mmol) of tetrakis (triphenylphosphamine) palladium (0) in 93 mL of dioxane and 24 mL of water. Providing 7.5 g (86%) of the title compound. Analysis calculated for C? 9H23N03S:% C, 66.06; % H, 6.71; % N, 4.05. Found:% C, 66.06; % H, 6.70; % N, 4.10. Mass Spectrum Desorption Field: M = 345.

EXAMPLE 48 2-propanesulfonamide of N-2- (4- (2- (hydroxymethyl) phenyl) phenyl) propyl Prepared as in Example 46, using 2.0 g (5.08 mmol) of the material of Example 47 and 0.22 g (5.08 mmol) of sodium borohydride in 5 mL of ethanol. 1.7 g (84%) of the title compound was provided. Analysis calculated for C? 9H25N03S:% C, 65.68; % H, 7.25; % N, 4.03. Found:% C, 65.14; % H, 6.73; % N, 3.76. Mass Spectrum Desorption Field: M = 347 EXAMPLE 49 2-propanesulfonamide of N-2- (4- (4- (2-t-butoxycarbonylamino) ethyl) phenyl) phenylpropyl To a solution of 2.0 g (3.8 mmol) of material from Preparation 40 and 1.4 g (4.5 mmol) of material from the Preparation 41 in 15 mL of toluene was added 0.2 g (0.2 mmol) of tetrakis (triphenyphosphamine) palladium (0). The mixture was heated at 100 ° C for 6.5 hours, cooled to room temperature and diluted with 15 mL of ethyl ether. The mixture was washed once with 15 mL of saturated aqueous potassium fluoride, the organic layer was separated and the aqueous layer was extracted three times with 10 mL each of ethyl ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (100 g silica gel, 30% ethyl acetate / hexane) of the residue afforded 0.6 g (35%) of the title compound. Analysis calculated for C 26 H 36 N 204 S:% C, 65.19; % H, 7.88; % N, 6.08. Found:% C, 65.29; % H, 7.84; % N, 5.84 Mass spectrum: M = 460 EXAMPLE 50 2-propanesulfonamide of N-2- (4- (4- (2-aminoethyl) phenyl) phenyl) propyl A solution of 0.6 g (1.3 mmol) of material from Example 49 in 5 mL of 20% trifluoroacetic acid / dichloromethane was stirred at room temperature for 1.5 hours. The mixture was concentrated in vacuo and the residue was partitioned between 10 mL of dichloromethane and 5 mL of 5N aqueous sodium hydroxide. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of dichloromethane. The combined organics were dried (MgSO), filtered and concentrated in vacuo. The resulting solid was suspended in hexane, filtered, rinsed once with hexane and dried in vacuo at room temperature to give 0.4 g (88%) of the title compound.

Analysis calculated for C20H28N202S:% C, 66.63; % H, 7.83; % N, 7.77. Found; % C, 66.93; % H, 7.79; % N, 7.94. Mass Spectrum: M = 360.

EXAMPLE 51 2-propanesulfonamide of N-2- (4- (4- (2-methanesulfonamidoethyl) phenyl) phenyl) propyl To a room temperature solution of 0.1 g (0.3 mmol) of the material of Example 50 and 0.06 mL (0.4 mmol) of triethylamine in 2 mL of dichloromethane was added 0.03 mL (0.4 mmol) of methanesulfonium chloride. The mixture was stirred at room temperature for 16 hours. Chromatography (10 g silica gel, 50% ethyl acetate / hexane) of the reaction mixture afforded 0.1 g (94%) of the title compound.

Analysis calculated for C2? H3o 20 S2:% C, 57. 51; % H, 6. 8; % N, 6.39. Found:% C, 57.90; % H, 6.72; % N, 6.33. Mass Spectrum: M = 438.

EXAMPLE 52 2-propanesulfonamide of N-2- (4- (4-hydroxymethyl) phenyl) phenyl) propyl To a solution of 0.5 g (1.5 mmol) of material from Example 45 in 5 mL of ethanol was added 0.06 g (1.5 mmol) of sodium borohydride. The mixture was stirred at room temperature for 16 hours, concentrated in vacuo and partitioned between 10 mL of ethyl acetate and 5 mL of water. The organic layer was separated and the aqueous portion was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 60% ethyl acetate / hexanes) of the residue afforded 0.5 g (98%) of the title compound. Analysis calculated for C? 9H25N03S:% C, 65.68; % H, 7.25; % N, 4.03. Found:% C, 65.40; % H, 7.40; % N, 4.02 Mass Spectrum: M = 347.

EXAMPLE 53 N-2- (4-cyanophenyl) propyl 2-propanesulfonamide A suspension of 10.0 g (31.2 mmol) of the material of Preparation 39, 11.2 g (124.8 mmol) of copper cyanide (I) and 23.8 g (124.8 mmol) of copper iodide (I) in 230 mL of dry dimethylformamide were added. heated at 140 ° C for 16 hours, cooled to room temperature and concentrated in vacuo. The residue was suspended in 200 mL of ethyl acetate, filtered through celite and concentrated in vacuo. Chromatography (500 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 6.4 g (77%) of the title compound. Analysis calculated for C? 3H? 8N202S:% C, 58.62; % H, 6.81; % N, 10.51. Found:% C, 58.44; % H, 6.64; % N, 10.23. Mass Spectrum: M = 266.

EXAMPLE 54 2-propanesulfonamide of N-2- (4- (5-bromo- [1,2, 4] oxadiazol-3-yl) phenyl) propyl A suspension of 2.0 g (7.5 mmol) of material from Example 53, 0.8 g (3.8 mmol) of material from Preparation 45 and 1.3 g (12.0 mmol) in 3 mL of toluene was heated at 90 ° C for 7 hours, cooled and diluted with 10 mL of ethyl acetate. The mixture was washed once with 10 mL of water, the organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (150 g of silica gel, 30% ethyl acetate / hexane) of the residue afforded a solid which was recrystallized from ethyl ether to provide 0.06 g (4%) of the title compound. Analysis calculated for Ci4H? 8N2Br03S:% C, 43.31; % H, 4.67; % N, 10.82. Found:% C, 43.58; % H, 4.65; % N, 10.76. Mass Spectrum: M-l = 387.

EXAMPLE 55 N-2- (4- (2-furyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of material from Example 27 and 0.6 g (1.7 mmol) of 2- (tributylstannyl) -furan in 5 mL, dioxane was added 0.1 g (0.1 mmol) of tetrakis (triphenylphosphamide) palladium (O) The mixture was refluxed for 16 hours, cooled to room temperature and diluted with 5 mL of ethyl ether. The mixture was washed once with 5 mL of saturated aqueous potassium fluoride, the organic layer was separated and the aqueous portion was extracted three times with 5 mL, each of ethyl ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 25% ethyl acetate / hexane) of the residue gave a yellow oil which was recrystallized from the ethyl ether / hexane to give 0.2 g (51%) of the title compound. Analysis calculated for C? 6H21N03S:% C, 62.51; % H, 6.89; % N, 4.56. Found:% C, 62.73; % H, 6.90; % N, 4.31. Mass Spectrum: M = 307.

EXAMPLE 56 2-propanesulfonamide of N-2- (4- (4- (2-N, N-dimethylaminosulfonamido) ethyl) phenyl) phenyl) propyl The title product was prepared from N, N-dimethylsulfamoyl chloride as described in Example 51. Analysis calculated by C 22 H 33 N 30 S 2:% C, 56.50; % H, 7.11; % N, 8.99. Found:% C, 56.21; % H, 7.20; % N, 8.71. Mass Spectrum: M = 467.

EXAMPLE 57 2-propanesulfonamide of N-2- (4- (2- (4, 5-dihydro) thiazolyl) phenyl) propyl A solution of 0.2 g (0.8 mol) of material from Example 53 and 0.1 g (1.5 mmol) of 2-aminoethanethiol in 5 mL of ethanol was heated to reflux for 16 hours, cooled to room temperature and concentrated in vacuo. Chromatograph (25 g of silica gel, 50% ethyl acetate / hexane) of the residue to give 0.2 g (86%) of the title compound. Analysis calculated by C 15 H 22 2 O 2 S 2% C, 55.18; % H, 6.79; % N, 8.58. Found:% C, 55.03; % H, 6.73; % N, 8.37 Mass Spectrum: M = 326.

EXAMPLE 58 N-2- (4- (4-cyanophenyl) phenyl) propyl 2-propanesulfonamide To a degassed or gas-free solution of 4. 0 g (12.4 mmol) of material from Example 27, 2.0 g (13.6 mmol) of material from Preparation 42 and 1.9 g (13.6 mmol) of potassium carbonate in 73 mL of dioxane / 75% water, 0.7 g was added. (0.6 mmol) of tetrakis (triphenylphosphamide) palladium (0). The mixture was heated at 100 ° C for 16 hours, cooled to room temperature, diluted with 30 mL of water and extracted three times with 35 mL each of ethyl ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (250 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 2.3 g (56%) of the title compound as a pale yellow solid. Recrystallization of 0.16 g of chlorobutane gave 0.12 g of the pure title compound. Analysis calculated by C? 9H22N202S:% C, 66.64; % H, 6.48; % N, 8.18. Found:% C, 66.86; % H, 6.42; % N, 8.09. Mass Spectrum: M = 342.

EXAMPLE 59 2-propanesulfonamide of N-2- (4- (4-t-butoxycarbonylaminomethyl) -phenyl) phenyl) propyl A. N-2- (4- (4-aminomethylphenyl) phenylpropyl 2-propanesulfonamide hydrochloride: A solution of 2.2 g (6.4 mmol) of material from Example 58 in 70 mL of ethanol and 3 mL of 1N hydrochloric acid was hydrogenated in the presence of 0.2 g of palladium on carbon at 5% at room temperature and 60 psi for 16 hours The mixture was filtered through celite and concentrated in vacuo.To this residue was added 4 mL of 1 N hydrochloric acid and The mixture was concentrated in vacuo.The residue was dissolved in 10 mL of ethanol and the mixture was concentrated in vacuo.The residue was suspended in 50 mL of ethyl acetate and stirred for one hour, filtered and dried in vacuo to give 1.7 g. (75%) of the title compound.

B. To a suspension of 1.1 g (3.3 mmol) in 10 mL of dichloromethane was added 0.5 mL (3.6 mmol) of triethylamine and the mixture was stirred for 15 minutes. To this mixture was added 0.7 g (3.3 mmol) of di-tert-butyl dicarbonate and the mixture was stirred for 16 hours at room temperature. The mixture was washed once with 5 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted twice with 5 mL each of dichloromethane. The combined organics were dried (Na2SO4), filtered and concentrated in vacuo. Chromatography (75 g of silica gel, 30% ethyl acetate / hexane) of the residue afforded 0.5 g (32%) of the title compound. Analysis calculated for C24H34N20S:% C, 64.55; % H, 7.67; % N, 6.27. Found:% C, 64.70; % H, 7.69; % N, 6.39. Mass Spectrum: M = 446.

EXAMPLE 60 Salt of trifluoroacetic acid of N-2- (4- (4-aminomethyl) phenyl) phenyl) propyl 2-propanesulfonamide A solution of 0.5 g (1.0 mmol) of 'material from the Example 59 in 5 mL of 20% trifluoroacetic acid / dichloromethane was stirred at room temperature for two hours. The mixture was concentrated in vacuo, dissolved in 5 mL of dichloromethane and washed with 5 mL of saturated aqueous sodium bicarbonate. The organic layer was separated and the aqueous layer was extracted three times with 5 mL of dichloromethane each. The combined organics were dried (Na 2 SO), filtered and concentrated in vacuo. To this residue was added 4 mL of dichloromethane and the resulting precipitate was filtered, rinsed with ethyl ether and dried in vacuo at 60 ° C affording 0.2 g (49%) of the title compound. Analysis calculated by C? 9H26N2? 2S »C2H02F3:% C, 54.77; % H, 5.91; % N, 6.08. Found:% C, 54.70; % H, 5.95; % N, 6.11. Mass Spectrum: M = 346.

EXAMPLE 61 N-2- (4- (2-thienyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of material from Example 27, 0.3 g (2.3 mmol) of thiophene-2-boronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 7 mL of dioxane and 2 mL of water , 0.1 g (0.1 mmol) of tetrakis (triphenylphosphamide) palladium (0) was added. The mixture was heated at 100 ° C for 16 hours, cooled to room temperature, dissolved with 5 mL of water and extracted three times with 5 mL of ethyl ether each. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. The residue was recrystallized from ethyl ether, filtered and dried in vacuo to provide 0.2 g (47%) of the title compound. Analysis calculated by C 16 H 21 NO 2 S 2:% C, 59.41; % H, 6.54; % N, 4.33. Found:% C, 59.36; % H, 6.44; % N, 4.11. Mass Spectrum: M = 323.

EXAMPLE 62 2-propanesulfonamide of N-2- (4- (4- (l-hydroxy-2-methanesulfonamidoethyl) phenyl) phenyl) propyl A solution of 0.3 g (0.5 mmol) of material from Preparation 44 (Step D) in 3.5 mL of 14% trifluoroacetic acid / dichloromethane was stirred at room temperature for four hours. 0.5 mL of trifluoroacetic acid was added and the mixture was heated at 50 ° C for two hours. The mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in 5 mL of dichloromethane once with 5 mL of saturated aqueous sodium bicarbonate. The organic layer was separated and the aqueous layer was extracted three times with 5 mL of dichloromethane each. The combined organics were dried (Na2SO4), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.1 g (51%) of the title compound. Analysis calculated by C21H30N205S2. 0. 05 CHC13:% C, 54. 89; % H, 6.58; % N, 6.08. Found:% C, 54.66; % H, 6.79; % N, 6.27. Mass Spectrum: M = 454.

EXAMPLE 63 N-2- (4- (5-tetrazolyl) phenyl) propyl 2-propanesulfonamide 0. 2 g (0.8 mmol) of material from Example 53 and 0.5 g (1.5 mmol) of azidotributylstannane was heated at 80 ° C for 72 hours. The mixture was cooled to room temperature, 5 L a saturated methanolic HCl solution was added, the mixture was stirred for 30 minutes and concentrated in vacuo. The residue was dissolved in 10 mL of acetonitrile and extracted four times with 5 mL each of hexane. The acetonitrile layer was concentrated in vacuo and the resulting solid was suspended in 10 mL of ethyl ether, filtered and dried in vacuo at 60 ° C to provide 0.2 g (89%) of the title compound. Analysis calculated by C13H? 9N502S:% C, 50.47; % H, 6.19; % N, 22.64. Found:% C, 50.19; % H, 6.11; % N, 22.54.

Mass Spectrum: M + l = 310, EXAMPLE 64 2-propanesulfonamide of N-2- (4- (5- (2-methyl) tetrazolyl) phenyl) propyl A solution of 0.1 g (0.3 mmol) of material from Example 63, 0.07 g (0.5 mmol) of potassium carbonate and 0.03 mL (0.4 mmol) of methyl iodide in 2 mL of N, N-dimethylformamide was heated to 80 °. C for 16 hours. The mixture was cooled to room temperature, diluted with 10 mL of water and extracted four times with 5 mL each of dichloromethane. The combined organics were dried (Na 2 SO), filtered and concentrated in vacuo. The • chromatography (10 g of silica gel, 25% ethyl acetate / hexane) of the residue gave 0.05 g (48%) of the title compound. Analysis calculated by C? 4H2? N502S:% C, 51.99; % H, 6.54; % N, 21.65. Found:% C, 52.28; % H, 6.54; % N, 21.83. Mass Spectrum: M = 323.

EXAMPLE 65 N-2- (4- (2-thiazolyl) phenyl) propyl 2-propanesulfonamide A solution of 0.7 g (2.1 mmol) of material from Preparation 39, 0.5 g (2.2 mmol) of material from Preparation 46 and 0.1 g (0.1 mmol) of tetrakis (triphenylphosphamide) palladium (0) in 6 mL of dioxane were added. heated at 100 ° C for 16 hours. The mixture was cooled to room temperature, diluted with 10 mL of ethyl ether and washed once with 10 L of saturated aqueous potassium fluoride. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (30 g of silica gel, 45% ethyl acetate / hexane) of the residue gave an oil which was crystallized from ethyl ether, filtered and dried in vacuo at 60 ° C to provide 0.3 g (41%) of the composed of the title. Analysis calculated by Ci5H2o 202S2:% C, 55.53; % H, 6.21; % N, 8.63. Found:% C, 55.75; % H, 6.29; % N, 8.63. Mass Spectrum: M = 324.

EXAMPLE 66 2-propanesulfonamide of N-2- (4- (2- (4S-methoxycarbonyl-4, 5-dihydro) thiazolyl) phenyl) propyl A solution of 0.3 g (0.9 mmol) of material from Example 53, 0.3 g (1.9 mmol) of L-cysteine methyl ester hydrochloride and 0.3 mL (1.9 mmol) of triethylamine in 5 mL of ethanol was heated to reflux for 16 h. hours. The mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in 5 mL of ethyl acetate and washed once with 5 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 45% ethyl acetate / hexane) of the residue afforded 0.05 g (15%) of the title compound. Mass Spectrum: M = 384.

EXAMPLE 67 2-propanesulfonamide of N-2- (4- (2- (4R-methoxycarbonyl-4, 5'-dihydro) thiazolyl) phenyl) propyl A solution of 0.3 g (0.9 mmol) of material from Example 53, 0.2 g - ( 1.4 mmol) of D-cysteine methyl ester hydrochloride and 0.2 mL (1.4 mmol) of triethylamine in 5 mL of ethanol was heated to reflux for 16 hours. To the mixture was added 0.16 g (0.9 mmol) of D-cysteine methyl ester hydrochloride and 0.14 mL (0.9 mmol) of triethylamine and reflux continued for 7 hours. The mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in 5 mL of ethyl acetate and washed once with 5 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 45% ethyl acetate / hexane) of the residue afforded 0.04 g (11%) of the title compound. Analysis calculated by C? 7H24N204S2:% C, 53.10; % H, 6.29; % N, 7.29. Found:% C, 52.99; % H, 6.35; % N, 7.49. Mass Spectrum: M = 384.

EXAMPLE 68 2-propanesulfonamide of N- (2- (4- (4- (2- (2-propane) sulfonamide) ethyl) phenyl) phenyl) propyl To a solution of 0.1 g (0.3 mmol) of material of Example 50 and 0.07 mL (0.5 mmol) of triethylamine in 1 mL of dichloromethane was added 0.04 mL (0.3 mmol) of isopropylsulfonyl chloride. The mixture was stirred at room temperature for 16 hours. The mixture was washed once with 1.5 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted twice with 1 mL each of dichloromethane. The combined organics were dried (Na2SO4), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.05 g (39%) of the title compound. Analysis calculated by C23H34N204S2:% C, 59.20; % H, 7.34; % N, 6.00. Found:% C, 59.08; % H, 7.33; % N, 5.76. Mass Spectrum: M = 466.

EXAMPLE 69 2-propanesulfonamide of N-2- (4- (5-formylthien-3-yl) phenyl) propyl To a degassed or gas-free solution of 0.4 g (0.8 mmol) of Preparation 40 material and 0.09 mL (0.8 mmol) of 4-bromo-2-thiophenecarboxaldehyde in 3 mL of dioxane was added 0.05 g (0.04 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 16 hours, cooled to room temperature and diluted with 3 mL of ethyl acetate. The mixture was washed once with 3 mL of saturated aqueous potassium fluoride. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded a solid which was suspended in ethyl ether, filtered and dried in vacuo to provide 0.1 g (42%) of the Title. Analysis calculated by C? 7H2? N03S2:% C, 58.09; % H, 6.02; % N, 3.99. Found:% C, 58.29; % H, 6.04; % N, 3.71. Mass Spectrum: M = 351.

EXAMPLE 70 2-propanesulfonamide of N-2- (4- (5-hydroxymethyl-3-yl) phenyl) propyl A solution of 0.09 g (0.3 mmol) of material from Example 69 in 2 mL of ethanol was added 0.01 g (0.3 mmol) of sodium borohydride. The mixture was stirred at room temperature for 16 hours and concentrated in vacuo. The residue was divided between 5 mL of ethyl acetate and 5 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organics were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (1 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.06 g (69%) of the title compound. Mass Spectrum: M = 353.

EXAMPLE 71 2-propanesulfonamide of N-2- (4- (4- (1-hydroxyethyl) phenyl) phenyl) propyl To a solution of 0.2 g (0.4 mmol) of material from Example 45 in 3 mL of tetrahydrofuran at room temperature was added 0.3 mL (0.9 mmol) of a 3.0M solution of methylmagnesium bromide in ethyl ether. The mixture was stirred for 16 hours, dissolved with 5 mL of water and extracted four times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (10 g silica gel, 45% ethyl acetate / hexane) of the residue afforded 0.1 g (74%) of the title compound. . Analysis calculated by C20H27N03S. 0.2CHC13:% C, 62.96; % H, 7.11; % N, 3.63. Found:% C, 63.31; % H, 7.02; % N, 3.62. Mass Spectrum: M = 361.

EXAMPLE 72 2-propanesulfonamide of N-2- (4- (4- (1-hydroxypropyl) phenyl) phenyl) propyl To a solution of 0.3 g (0.7 mmol) of material from Example 45 in 4 mL of tetrahydrofuran at room temperature was added 0.5 mL (1.5 mmol) of 3.0M ethylmagnesium bromide solution in ethyl ether. The mixture was stirred for 16 hours, dissolved with 5 mL of semi-saturated brine and extracted four times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (15 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.1 g (42%) of the title compound. Analysis calculated by C21H29N03S:% C, 67.17; % H, 7.78; % N, 3.73. Found:% C, 66.95; % H, 7.69; % N, 3.59.

Mass Spectrum: M = 375.

EXAMPLE 73 N-2- (4-4-carboxyphenyl) phenyl) propanesulfonamide 2-propanesulfonamide To a degassed or gas-free solution of 1.0 g (3.1 mmol) of preparation material 39, 0.8 g (4.7 mmol) of 4-carboxyphenylboronic acid and 0.7 g (4.7 mmol) of potassium carbonate in 20 mL of 75% water / dioxane was added 0.2 g (0.2 mmol) of tetrakis (triphenylphosphamine) -palladium (O). The mixture was heated at 100 ° C for 16 hours, cooled to room temperature and dissolved with 15 mL of 10% aqueous sodium bisulfate. The mixture was extracted three times with 20 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Recrystallization of the chlorobutane residue gave 0.4 g (37%) of the title compound. A 0.1 g sample was recrystallized to provide 0.07 g of the pure title compound. Analysis calculated by C19H23N04S:% C, 63.14; % H, 6.41; % N, 3.88. Found:% C, 63.25; % H, 6.42; % N, 3.79. Mass Spectrum: M = 361.

EXAMPLE 74 N-2- (4- (4-carbamoylphenyl) phenyl) propyl 2-propanesulfonamide To a 0 ° C solution of 0.3 g (0.9 mmol) of material from Example 73 and 0.1 mL (0.9 mmol) of 4-methyl-morpholine in 5 mL of dichloromethane was added 0.1 mL (0.9 mmol) of isobutylchloroformate and the mixture it was stirred at 0 ° C for 30 minutes. One third of the mixture was added to 2 mL of 2.0 M ammonium in methanol at 0 ° C and the cooling solution was removed. After 20 minutes, the resulting solid was filtered and dried in vacuo at 60 ° C to provide 0.034 g (33%) of the title compound. Analysis calculated by C? 9H24N203:% C, 63.31; % H, 6.71; % N, 7.77. Found:% C, 63.68; % H, 6.85; % N, 7.61. Mass Spectrum: M = 360.

EXAMPLE 75 2-propanesulfonamide of N-2- (4- (4-methylcarbamoylphenyl) phenyl) propyl To a 0 ° C solution of 0.9 g (2.4 mmol) of material from Example 73 and 0.3 mL (2.5 mmol) of 4-methyl-orpholine in 5 mL of dichloromethane was added 0.3 mL (2.5 mmol) of isobutylchloroformate and the mixture it was stirred at 0 ° C for 30 minutes. To the mixture was added 10 mL of 40% aqueous methylamine at 0 ° C and the cold bath was removed. After one hour, 10 mL of water was added, the organic layer was separated and the aqueous layer was extracted three times with 5 mL each of dichloromethane. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Recrystallization of methanol / chlorobutane gave 0.4 g (44%) of the title compound. Analysis calculated by C 20 H 26 N 2 O 3 S:% C, 64.14; % H, 7.00; % N, 7.48. Found:% C, 63.97; % H, 6.92; % N, 7.33. Mass Spectrum: M = 374.

EXAMPLE 76 2-propanesulfonamide of N-2- (4- (4-dimethylcarbamoylphenyl) phenyl) propyl To a 0 ° C solution of 0.3 g (0.9 mmol) of material from Example 73 and 0.1 mL (0.9 mmol) of 4-methyl-morpholine in 5 mL of dichloromethane was added 0.1 mL (0.9 mmol) of isobutylchloroformate and the mixture it was stirred at 0 ° C for 30 minutes. One third of the mixture was added to 2 mL of 2.0 M dimethylamine in tetrahydrofuran at 0 ° C and the cooling bath was removed. After 25 minutes, the mixture was dissolved with 5 mL of ethyl acetate and washed once with 5 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 2 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. The residue was crystallized from ethyl ether, filtered and dried in vacuo at 60 ° C to provide 0.04 g (36%) of the title compound. Analysis calculated by C21H28N203 S:% C, 64.92; % E, 7.26; % N, 7.21. Found:% C, 64.84; % H, 7.19; % N, 6.92. Mass Spectrum: M = 388.

EXAMPLE 77 N-2- (4- (4-acetylphenyl) phenyl) propyl 2-propanesulfonamide To a degassed or gas-free solution of 1.0 g (3.1 mmol) of material from Preparation 39, 0.8 g (4.7 mmol) of 4-acetylphenylboronic acid and 0.7 g (4.7 mmol) of potassium carbonate in 20 mL of dioxane / 75% water, 0.2 g (0.2 g) was added. mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 4.5 hours, cooled to room temperature and diluted with 15 mL of water. The resulting solid was filtered, dried and recrystallized from chlorobutane to provide 0.7 g (65%) of the title compound. Analysis calculated by C2oH25N03S:% C, 66.82; % H, 7.01; % N, 3.90. Found:% C, 66.95; % H, 7.16; % N, 3.63. Mass Spectrum: M = 359.

EXAMPLE 78 2-propanesulfonamide of N-2- (4- (2- (5-formyl) thienyl) phenyl) propyl To a degassed or gas-free solution of 0.4 • g (0.8 mmol) of material from preparation 40 and 0.09 mL (0.8 mmol) of 5-bromo-2-thiophenecarbexaldehyde in 3 mL of dioxane was added 0.05 g (0.04 mmol) of tetrakis- (triphenylphosphamide) palladium (O). The mixture was heated at 100 ° C for 16 hours, 0.04 mL (0.4 mmol) of 5-bromo-2-thiophenecarboxaldehyde was added and heated continuously for 6 hours. The mixture was cooled to room temperature and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded a solid which was suspended in ethyl ether, filtered and dried in vacuo to provide 0.06 g (24%) of the title compound. Analysis calculated by C? 7H21N03S2:% C, 58.09; % H, 6.02; % N, 3.99, Found:% C, 58.22; % H, 6.07; % N, 3.69. Mass Spectrum: M = 351.

EXAMPLE 79 2-propanesulfonamide of N-2- (4- (2- (5-hydroxymethyl) thienyl) phenyl) propyl To a solution of 0.03 g (0.08 mmol) of material from Example 78 in 1 mL ethanol was added 0.003 g (0.08 mmol) of sodium borohydride. The mixture was stirred at room temperature for 2 hours, concentrated in vacuo and partitioned between 2 mL of ethyl acetate and 2 mL of water. The organic layer was separated and the aqueous portion was extracted three times with 1 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (1 g of silica gel, 35% ethyl acetate / hexane) of the residue gave 0.02 g (64%) of the title compound. Analysis calculated by C? 7H23N03S2. 0. 05CHC1,:% C, 56. 97; % H, 6.46; % N, 3.90. Found:% C, 57.13; % H, 6.34; % N, 3. 75. Mass Spectrum: M = 353.

EXAMPLE 80 2-propanesulfonamide of N-2- (4- (2- (5-methoxycarbonyl) thiazolyl) phenyl) propyl To a solution at 0 ° C of 2.0 g (5.2 mmol) of material from Example 66 and 0.9 mL (5.8 mmol) of 1,8-diazabicyclo [5.4.0] ndec-7-ene in 15 mL dichloromethane was added 0.5 mL (5.8 mmol) of bromotrichloromethane in drop form for 8 minutes. The mixture was stirred at 0 ° C for 2 hours and washed once with 10 mL of saturated aqueous ammonia chloride. The organic layer was separated and the aqueous layer was extracted twice with 10 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (100 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 1.5 g (76%) of the title compound. Analysis calculated by C? 7H22N204S2:% C, 53.38; % H, 5.80; ' % N, 7.32. Found:% C, 53.08; % H, 5.94; % N, 7.18.

Mass Spectrum: M = 382.

EXAMPLE 81 N-2- (4- (2-aminophenyl) phenyl) propyl 2-propanesulfonamide To a degassed or gas-free solution of 0.5 g (0.9 mmol) of material from preparation 40 and 0.2 g (0.9 mmol) of 2-bromoaniline in 3 mL of toluene was added 0.06 g. (0.05 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated to 100 ° C for 16 hours after which 0. 03 g (0.03 mmol) of tetrakis (triphenylphosphamine) palladium (0) was added and heated continuously for 16 hours. The mixture was cooled to room temperature and chromatographed (25 g of silica gel, 35% ethyl acetate / hexane) to provide in oil which was crystallized from chlorobutane / hexane to provide 0.06 g (20%) of the title compound. Analysis calculated by C? 8H24N202S:% C, 65.03; % H, 7.28; % N, 8.43. Found:% C, 65.17; % H, 7.40; % N, 8.29. Mass Spectrum: M = 332.

EXAMPLE 82 N-2- (4- (4-phenyl) phenyl) propyl 2-propanesulfonamide To a degassed or gas-free solution of 0.5 g (1.6 mmol) of preparation material 39, 0.3 g (2.3 mmol) of phenylboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 9 mL, of 7: dioxane water was added 0.09 g (0.08 mmol) of tetrakis (triphenyl phenamide) palladium (0). The mixture was heated at 100 ° C for 16 hours, cooled to room temperature and dissolved with 5 mL of water. The mixture was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 0.4 g (71%) of the title compound. Analysis calculated by C? 8H23N02S:% C, 68.14; % H, 7.30; % N, 4.41. Found:% C, 67.81; % H, 7.23; % N, 4.61. Mass Spectrum: M = 317.

EXAMPLE 83 2-propanesulfonamide of N-2- (4- (2- (5-carboxy) thiazolyl) phenyl) propyl To a solution of 1.4 g (3.7 mmol) of material from Example 80, in 25 mL, of 4: 1 methanol / tetrahydrofuran, 4.1 mL (4.1 mmol) of 1 N aqueous sodium hydroxide was added. After 5 hours added 1.0 mL (1.0 mmol) of 1 N aqueous sodium hydroxide. The mixture was stirred for 16 hours and concentrated in vacuo. The residue was dissolved in 25 mL of water and extracted once with ethyl ether. The organic layer was discharged and the aqueous layer was acidified to pH 2 with 10% aqueous sodium bisulfate. The aqueous layer was extracted four times with 25 mL each of ethyl acetate and the combined organics were dried (MgSO 4), filtered and concentrated in vacuo. The resulting solid was suspended in ethyl ether, filtered and dried in vacuo to provide 1.0 g (70%) of the title compound. A 0.2 g sample was recrystallized from ethyl acetate / methanol to provide 0.1 g of the pure title compound. Analysis calculated by CJ.6H202O2S2:% C, 52.15; % H, 5.47; % N, 7.60, Found:% C, 52.24; % H, 5.40; % N, 7.42. Mass Spectrum: M = 368.

EXAMPLE 84 2-propanesulfonamide of N-2- (4- (4- (2-cyanoethenyl) phenyl) phenyl) propyl To a suspension of 0.4 g (10.4 mmol) of sodium hydride (washed three times with hexane) in 2 mL of tetrahydrofuran was added 1.6 mL (10.4 mmol) of diethyl cyanomethylphosphonate. The mixture was stirred at room temperature for 15 minutes. To the mixture was added a solution of 3.0 g (8.7 mmol) of material from Example 45 in 15 mL of tetrahydrofuran. After stirring for two hours, the mixture was dissolved with 25 mL of water and extracted three times with 20 mL each of ethyl ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (150 g of gel of • silica, 35% ethyl acetate / hexane) of the residue gave a white solid which was suspended in ethyl ether, filtered and dried in vacuo to give 2.5 g (79%) of the title compound. Analysis calculated by C2? H24N202S:% C, 68.45; % H, 6.56; % N, 7.60. Found:% C, 68.65; % H, 6.49; % N, 7.55. Mass Spectrum M = 368.

EXAMPLE 85 2-propanesulfonamide of N-2- (4- (3- (2-bromo) thienyl) phenyl) propyl To a solution of 0.1 g (0.3 mmol) of material from Example 28 in 0.5 mL of acetic acid / chloroform 1: 1 was added to suspension of 0.06 g (0.3 mmol) of N-bromosuccinamide in 1 mL of acetic acid / chloroform 1 :1. The mixture was stirred at room temperature for one hour and dissolved with 1.5 mL of water. The organic layer was separated, washed once with 1 N aqueous sodium hydroxide, dried (MgSO), filtered and concentrated in vacuo. The residue was dissolved in 1 mL of dichloromethane, filtered through a silica gel plug eluting with 35% ethyl acetate / hexane and concentrated in vacuo to provide 0.1 g (72%) of the title compound. Analysis calculated by C 16 H 20 NO 2 S 2 Br:% C, 47. 76; % H, 5. 01; % N, 3.48. Found:% C, 48.02; % H, 5.22; % N, 3.48. Mass Spectrum: M + 2 = 404.

EXAMPLE 86 2-propanesulfonamide of N-2- (4- (4- (2- (N- (t-butoxycarbonyl) methylsulfonamido) ethanoyl) phenyl) phenyl) propyl A. N- (4-tri-n-butylstannylphenyl) carbonylmethyl-N-t-butoxycarbonyl-methanesulfonamide. To a degassed or gas-free solution of 5.0 g (12.7 mmol) of material from Preparation 44 (Stage B), 7.1 mL, (14.0 mmol) of bis (tributyltin) and 2.0 mL (14.0 mmol) of triethylamine in 35 mL of toluene was added 0.7 g (0.6 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was refluxed for 16 hours, cooled to room temperature and dissolved with 35 mL of ethyl acetate. The mixture was washed once with 30 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 15 mL each of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (200 g of silica gel, 5% ethyl acetate / hexane) of the residue afforded 2.2 g (28%) of the title compound. Analysis calculated by C26H45N05S Sn:% C, 51.84; % H, 7.53; % N, 2.33. Found:% C, 52.12; % H, 7.56; % N, 2.57. Mass Spectrum: M + 2 = 604.

B. To a degassed or gas-free solution of 1.1 g (3.5 mmol) of material from Preparation 39, 2.1 g (3.5 mmol) of material from Step A in 10 mL of toluene was added 0.2 g (0.2 mmol). of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 92 ° C for 16 hours, 0.2g (0.2 mmol) of tetrakis (triphenylphosphamide) palladium (0) was added and heating continued for four hours. The mixture was cooled to room temperature and diluted with 5 mL of ethyl acetate. 5 mL of the saturated aqueous potassium fluoride was added and the mixture was stirred for one hour. The mixture was filtered through diatomaceous earth, the organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 40% ethyl acetate / hexane) of the residue gave a dark solid which was suspended in ethyl ether, filtered and dried in vacuo to give 0.2 g (10%) of the compound of the title. Analysis calculated by C 26 H 36 N 207 S 2:% C, 56.50; % H, 6.57; % N, 5.07. Found:% C, 56.56; % H, 6.73; % N, 5.18. Mass Spectrum: M = 552.

EXAMPLE 87 2-propanesulfonamide of N-2- (4- (4- (2-methanesulfonamid) ethanoyl) phenyl) phenyl) propyl A solution of 0.2 g (0.3 mmol) of material from Example 86 in 2.5 mL of 20% trifluoroacetic acid / dichloromethane was stirred at room temperature for 1.5 hours. The mixture was concentrated in vacuo, dissolved in 5 mL of dichloromethane and washed with 5 mL of saturated aqueous sodium bicarbonate. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of dichloromethane. The combined organics were dried (Na 2 SO), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 60% ethyl acetate / hexane) of the residue afforded 0.1 g (60%) of the title compound. Analysis calculated by C2? H28N2OsS2:% C, 55.73; % H, 6.24; % N, 6.19. Found:% C, 55.44; % H, 6.17; % N, 6.15. Mass Spectrum: M = 452.

EXAMPLE 88 2-propanesulfonamide of N-2- (4- (4- (4- (1,1-dioxotetrahydro-1,2-thiazinyl) phenyl) phenyl) propyl A solution of 0.1 g (0.4 mmol) of the material of preparation 49 and 0.2 g (0.4 mmol) of material from preparation 40 in 2 mL of 20% dioxane / toluene was added 4 mg (0.02 mmol) of palladium acetate ( II) and 9 mg (0.04 mmol) of triphenylphosphamide. The mixture was heated to 100 ° C for 16 hours and 0.1 g (0.2 mmol) of material from preparation 40 was added. Heating continued for 8 hours. The mixture was cooled to room temperature, dissolved with 2 mL of ethyl acetate and 1 mL of saturated aqueous potassium fluoride was added. After stirring for one hour the organic layer was separated and the aqueous layer was extracted three times with 1 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 40% ethyl acetate / hexane) of the residue afforded 0.04 g (22%) of the title compound. Analysis calculated by C22H30N204S2:% C, 58.64; % H, 6.71; % N, 6.22. Found:% C, 58.34; % H, 6.77; % N, 6.06. Mass Spectrum: M -1 = 449.

EXAMPLE 89 2-propanesulfonamide of N-2- (4- (5- (3-benzyl) tetrazolyl) phenyl) propyl A solution of 0.2 g (0.7 mmol) of material from Example 63, 0.1 g (1.0 mmol) of potassium carbonate and 0.09 mL (0.7 mmol) of benzyl bromide in 4 mL of N, N-dimethylformamide was heated to 80 °. C for 4 hours. The mixture was cooled to room temperature, diluted with 10 mL of water and extracted four times with 5 mL each of dichloromethane. The combined organics were dried (Na2SO4), filtered and concentrated in vacuo. Chromatography (20 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.2 g (79%) of the title compound. • Analysis calculated by C20H25N5O2S:% C, 60.13; % H, 6.31; % N, 17.53. Found:% C, 60.36; % H, 6.17; % N, 17.71. Mass Spectrum: M + 1 = 400.

EXAMPLE 90 2-propanesulfonamide of N-2- (4- (2- (4,5-dihydro-4-methoxycarbonyl-5,5-dimethyl) thiazolyl) phenyl) propyl A solution of 0.3 g (0.9 mmol) of material from Example 53 , 0.5 g C2.4 mmol) of material from preparation 50 and 0.3 mL (2.4 mmol) of triethylamine in 8 mL of ethanol was heated to reflux for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in 10 mL of ethyl acetate and washed once with 10 mL of water. The organic layer was separated and the aqueous portion was extracted three times with 5 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (15 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.17 g (43%) of the title compound. Analysis calculated by C? 9H28N204S2:% C, 55.31; % H, 6.84; % N, 6.79. Found:% C, 55.35; % H, 6.95; % N, 6.64. Mass Spectrum: M = 412.

EXAMPLE 91 2-propanesulfonamide of N-2- (4- (5- (2-ethyl) tetrazolyl) phenyl) propyl The title compound was prepared from the product of Example 63 as described in Example 64 with the exception that iodoethane was used in place of iodomethane.

Analysis calculated by C? 5H23N502S:% C, 53.39; % H, 6.87; % N, 20.75. Found:% C, 53.49; % H, 6.8-9; % N, 20.45. Mass Spectrum: M + 1 = 338.

EXAMPLE 92 2-propanesulfonamide of N-2- (4- (5- (2- (2-propyl)) tetrazolyl) phenyl) propyl The title compound was prepared from the product of Example 63 as described in Example 64 with the exception that 2-iodopropane was used in place of iodomethane. Analysis calculated by C? 6H25N5? 2S:% C, 54.68; % H, 7.17; % N, 19.93. Found:% C, 54.78; % H, 6.93; % N, 19.76. Mass Spectrum: M + l = 352.

EXAMPLE 93 2-propanesulfonamide of N-2- (4- (5- (2-prop-3-enyl) tetrazolyl) phenyl) propyl The title compound was prepared from the product of Example 63 as described in Example 64 with the exception that allyl bromide was used in place of iodomethane. Analysis calculated by C 16 H 23 N 502 S:% C, 54.99; % H, 6.63; % N, 20.04. Found:% C, 54.99; % H, 6.40; % N, 19.77. Mass Spectrum: M + l = 350.

EXAMPLE 94 N-2- (4- (4-aminophenyl) phenyl) propyl 2-propanesulfonamide A. N-2- (4- (4-t-butoxycarbonylaminophenyl) phenyl) propyl 2-propane-sulfonamide: A degassed or gas-free solution of 0.9 g (2.9 mmol) of material from Example 39, 1.4 g (2.8 mmol) of material from Preparation 51 and 0.2 g (0.1 mmol) of tetrakis (triphenylphosphamide) palladium (0) in 10 mL of toluene was heated to reflux for 5 hours. The mixture was cooled to room temperature and concentrated in vacuo. Chromatography (100 g of silica gel, 30% ethyl acetate / hexane) of the residue afforded 0.15 g (12%) of the title compound. Mass Spectrum: M = 432.

B. A solution of 0.2 g (0.5 mmol) of material from Step A in 2.5 mL of 20% trifluoroacetic acid / diclomethane was stirred at room temperature for two hours. The mixture was concentrated in vacuo, dissolved in 2 mL of dichloromethane and washed once with 1 mL of saturated aqueous sodium bicarbonate. The organic layer was separated and the aqueous layer was extracted three times with 1 mL each of dichloromethane. The combined organics were dried (Na2SO4), filtered and concentrated in vacuo. The residue was crystallized from chlorobutane / hexane to provide 0.03 g (20%) of the title compound. Analysis calculated by Ci8H24N202S:% C, 65.03; % H, 7.28; % N, 8.43. Found:% C, 65.11; % H, 7.52; % N, 8.23. Mass Spectrum: M = 350.

EXAMPLE 95 N-2- (4- (3-furyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.8 g (2.6 mmol) of Preparation 39 material and 1.0 g (2.9 mmol) of 3- (tributylstannyl) furan in 10 mL of dioxane was added 0.2 g (0.1 mmol) of tetrakis (triphenylphosphamine) palladium ( 0). The mixture was refluxed for 4 hours, cooled to room temperature and diluted with 10 mL of water. The mixture was extracted three times with 10 mL each of ethyl ether. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded a solid which was suspended in hexane, filtered and dried in vacuo to provide 0.3 g (42%) of the Title. Analysis calculated by C? 6H2? N03S:% C, 62.51; % H, 6.89; % N, 4.55. Found:% C, 62.64; % H, 6.92; % N, 4.69. Mass Spectrum: M = 307.

EXAMPLE 96 2-propanesulfonamide of N-2- (4- (2- (4-hydroxymethyl) thiazolyl) phenyl) propyl To a 0 ° C solution of 0.8 g (2.0 mmol) of material from Example 83 in 6 mL of tetrahydrofuran was added 0.4 mL (4.1 mmol) of 10 M boranodimethyl sulfide. The mixture was stirred at 0 ° C for 30 minutes and it was allowed to warm to room temperature for 16 hours. To the mixture was added 3 mL of saturated aqueous sodium bicarbonate slowly. The mixture was diluted with 10 mL of water and extracted four times with 10 mL each of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. The residue was filtered through 5 g of silica gel and concentrated in vacuo. Chromatography (2 g of silica gel, 50% ethyl acetate / hexane) of the residue gave 0.03 g (4%) of the title compound. Analysis calculated by C? 6H22N203S2 • 0. 05 CHC13:% C, 53. 48; % H, 6.17; % N, 7.77. Found:% C, 53.31; % H, 6.46; % N, 7. 93. Mass Spectrum: M = 354.

EXAMPLE 97 of N-2- (4- (4-fluorophenyl) phenyl) propylmethanesulfonamide To a degassed or gas-free solution of 1.5 • g (5.1 mmol) of material from Example 1, 1.1 g (7.7 mmol) of potassium carbonate and 1.1 g (7.7 mmol) of 4-fluorobenzeneboronic acid in 30 mL of toluene was added 0.2 g (0.3 mmol) of dichlorobis ( triphenylphosphamine) palladium (II). The mixture was heated at 100 ° C for 16 hours and cooled to room temperature. The mixture was diluted with 20 mL of ethyl acetate, filtered through diatomaceous earth and concentrated in vacuo. Chromatography (50 g of silica gel, 30% ethyl acetate / hexane) of the residue gave a white solid which was suspended in ethyl ether, filtered and recrystallized from chlorobutane to provide 0.2 g (12%) of the Title. Mass Spectrum Desorption Field: M = 307.

EXAMPLE 98 N-2- (4- (2, 3-difluorophenyl) phenyl) propylmethanesulfonamide To a solution of 0.4 g (0.8 mmol) of material from Preparation 52, 0.2 g (0.8 mmol) of 2,3-difluorophenyl-trifluoromethanesulfonate, 0.1 g (2.3 mmol) of lithium chloride in 5 mL of toluene was added 0.03. g (0.04 mmol) of dichlorobis (triphenylphosphine) palladium (II). The mixture was heated at 100 ° C for 16 hours and cooled to room temperature. The mixture was diluted with 5 mL of ethyl acetate and washed with 5 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organics dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded an oil which was crystallized from diethyl ether to provide 0.1 g (37%) of the title compound.

Analysis calculated by Ci6H17N02SF2:% C, 59.06; % H, 5.27; % N, 4.30. Found:% C, 59.05; % H, 5.14; -% N, 4.08. Mass Spectrum Desorption Field: M = 325.

EXAMPLE 99 of N-2- (4-bromophenyl) propyltrifluoromethanesulfonamide The title compound was prepared from the product of Preparation 2 as described in Preparation 39 with the exception that trifluoromethanesulfonyl chloride was used in place of isopropylsulfonyl chloride. Analysis calculated by C? 0HnN? SBrF3. :% C, 34.70; % H, 3.20; % N, 4.05. Found:% C, 34.95; % H, 3.32; % N, 4.00. Mass Spectrum Desorption Field: M + 1 = 347.

'EXAMPLE 100 N-2- (4- (2-formylphenyl) phenylpropylmetanesulfonamide The title compound was prepared from the product of Example 1 as described in Example 97 with the exception that 2-formylbenzeneboronic acid was used in place of 4-fluorbenzeneboronic acid and tetrakis (triphenylphosphamine) palladium (0) was used instead of dichlorobis- (triphenylphosphamine) palladium (II). Analysis calculated by C? 7H19N03S:% C, 64.33; % H, 6.03; % N, 4.41. Found:% C, 64.13; % H, 5.90; % N, 4.40. Mass Spectrum Desorption Field: M = 317.

EXAMPLE 101 N-2- (4- (2-methylphenyl) phenyl) propylmethanesulfonamide The title compound was prepared from the product of Example 1 as described in Example 100 with the exception that 2-methylbenzeneboronic acid was used in place of 2-formylbenzeneboronic acid and 10 mL of water was added to the reaction mixture. Analysis calculated by C17H2? N02S:% C, 67.29; % H, 6.98; % N, 4.62. Found:% C, 67.11; % H, 7.18; % N, 4.53. Mass Spectrum Desorption Field: M = 303.

EXAMPLE 102 N-2- (4- (4-methoxyphenyl) phenyl) propylmethanesulfonamide The title compound was prepared from the product of Example 1 as described in Example 6 with the exception that 4-methoxybenzeneboronic acid was used in place of 2-methoxybenzeneboronic acid. Analysis calculated by C? H21N03S:% C, 63.92; % H, 6.63; % N, 4.39. Found:% C, 63.92; % H, 6.50; % N, 4.18. Mass Spectrum Desorption Field: M = 319.

EXAMPLE 103 N-2- (4- (3-thienyl) phenyl) propyl 2-propanesulfonamide To a solution at 0 ° C of 3.1 g (14.4 mmol) of material from Preparation 53 (Step B) and 4.8 g (31.7 mmol) of 1,8-diazabicyclo [5.4.0) undec-7-ene in 50 mL of dichloromethane was added a solution of 2.8 g (15.8 mmol) of material from preparation 54 in 10 mL of dichloromethane. The mixture was stirred at 0 ° C for 30 minutes, the cooling bath was stirred and the mixture stirred for one hour. The reaction mixture was washed once with 30 mL of 10% aqueous sodium bisulfate. The organic layer was separated and the aqueous layer was extracted three times with 10 mL each of dichloromethane. The combined organics were dried (Na 2 SO), filtered and concentrated in vacuo. Chromatography (300 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 1.0 g (22%) of the title compound. Analysis calculated by Ci6H? 9N02S2,% C, 59.78; % H, 5.96; % N, 4.36. Found:% C, 59.90; % H, 6.10; % N, 4.26. Mass Spectrum Desorption Field: M + 1 = 322.

EXAMPLE 104 N-2- (4- (hydroxyiminoyl) phenyl) propyl 2-propanesulfonamide A solution of 0.5 g (1.9 mmol) of material from Preparation 43 and 0.14 g (2.0 mmol) of hydroxylamino hydrochloride in 6 mL of ethyl alcohol was heated to reflux for 18 hours. The mixture was cooled and concentrated in vacuo. The residue was divided between 5 mL of water and 5 mL of ethyl acetate. The organic layer was separated and the aqueous layer was extracted twice with 5 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo to provide 0.4 g (74%) of the title compound. Analysis calculated by C? 3H20N203S:% C, 54.91; % H, 7.09; % N, 9.85. Found:% C, 56.04; % H, 6.82; % N, 10.43. Mass Spectrum Desorption Field: M = 284.

EXAMPLE 105 2-propanesulfonamide of N-2- (4- (3- (5-hydroxymethyl) isoxazolyl) phenyl) propyl To a solution of 0.3 g (1.0 mmol) of material from Example 104 and 0.1 g (2.0 mmol) of propargyl alcohol and 0.3 g (3.0 mmol) of potassium bicarbonate in 3 mL of ethyl acetate and 1 drop of water, added 0.1 g (1.0 • mmol) of N-chlorosuccinimide. The mixture was stirred at room temperature for 18 hours and then 3 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (12 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.037 g (11%) of the title compound. Analysis calculated by d6H22N20S:% C, 56.79; % H, 6.55; % N, 8.28. Found:% C, 51.97; % H, 5.93; % N, 10.96. Mass Spectrum Desorption Field: M = 338.

EXAMPLE 106 2-propanesulfonamide of N-2- (4- (3- (5-methoxycarbonyl) isoxazolyl) phenyl) propyl A. N-2- (4- (l-hydroxy-2-chloroiminoyl) phenyl) ropyl 2-propanesulfonamide: To a solution of 1.0 g (3.5 mmol) of material of Example 104 in 10 mL of N, N-dimethylformamide 0.5 g (3.5 mmol) of solid N-chlorosuccinimide was added in small portions. The solution was stirred at room temperature for 3 hours. The mixture was poured into 40 L of ice and the aqueous layer was extracted three times with 10 mL each of ether, the combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to provide 1.25 g (100%) of the compound of the title.

B. To a solution of 0.5 g (1 mmol) of material of Example 106A and 0.3 g (3.1 mmol) of methyl propiolate in 3 mL of ethyl acetate and 1 drop of water was added 0.5 g (4.7 mmol) of potassium bicarbonate. The mixture was stirred at room temperature for 18 hours and then added 3 mL of water. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.34 g (51%) of the title compound. Analysis calculated by Ci.7H22N205S:% C, 55.72; % H, 6.05; % N, 7.64. Found:% C, 55.95; % H, 6.24; % N, 7.37. Mass Spectrum Desorption Field: M = 366.

EXAMPLE 107 2-propanesulfonamide of N-2- (4- (3- (5-carboxy) isoxazolyl) phenyl) propyl A solution of 0.3 g (0.8 mmol) of material from Example 106B in 3 mL of methyl alcohol and 1 mL (1 mmol) of 1N sodium hydroxide was heated at 50 ° C for 18 hours. To the mixture was added 1 mL (1 mmol) of 1N sodium hydroxide and the mixture was heated at 50 ° C for 7 hours. The mixture was cooled and concentrated in vacuo. The residue was divided between 3 mL of water and 3 mL of ether. The organic layer was separated and the aqueous layer was washed three times with 3 mL each of ether.

The aqueous layer was acidified to pH = 1 with concentrated hydrochloric acid. The aqueous layer was extracted three times with 3 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to give 0.11 g (39%) of the title compound. Analysis calculated by C? 6H20N205S:% C, 54.53; % H, 5.72; % N, 7.95. Found:% C, 55.80; % H, 5.27; % N, 7.74. Mass Spectrum Desorption Field: M = 352.

EXAMPLE 108 2-propanesulfonamide of N-2- (4- (3- (5-trimethylsilyl) isoxazolyl) phenyl) propyl To a solution of 0.5 g (1.6 mmol) of material from Example 106A and 0.3 g (3.1 mmol) of (trimethylsilyl) acetylene in 3 mL of ethyl acetate and 1 drop of water, 0.5 g (4.7 mmol) of bicarbonate was added. potassium. The mixture was stirred at room temperature for 18 hours and then 3 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.36 g (59%) of the title compound. Analysis calculated for C? 8H28N203SSi:% C, 56.81; % H, 7.42; % N, 7.36. Found:% C, 57.63; % H, 7.41; % N, 7.52. Mass Spectrum Desorption Field: M = 380 EXAMPLE 109 2-propanesulfonamide of N-2- (4- (3- (5-acetyl) isoxazolyl) phenyl) propyl To a solution of 0.07 g (0.2 mmol) of material from Example 106A and 0.029 g (0.4 mmol) of 3-butyn-2-one in 3 mL of ethyl acetate and 1 drop of water was added, 0.066 g. (0.6 mmol) of potassium bicarbonate. The mixture was stirred at room temperature for 18 hours and then 3 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (12 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.04 g (57%) of the title compound. Analysis calculated by CX7H22N204S:% C, 58.27; % H, 6.33; % N, 7.99. Found:% C, 59.08; % H, 6.29; % N, 7.36.

Mass Spectrum Desorption Field: M = 350.

EXAMPLE 110 2-propanesulfonamide of N-2- (4- (3- (5- (N '-methylcarbamoyl)) - isoxazolyl) phenyl) propyl A solution of 0.1 g (0.28 mmol) of material from Example 107 and 0.03 g (0.3 mmol) N-methylmorpholine in 2 mL of dichloromethane was cooled to 0 ° C. A solution of 0.033 mL (0.3 mmol) of isobutylchloroformate was added in 1 mL of dichloromethane and the mixture was stirred at 0 ° C for 30 minutes. The mixture was poured into 2 mL at 40% methylamine and water at 0 ° C and stirred for 30 minutes. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (12 g of silica gel, 50% ethyl acetate / hexane) of the residue gave 0.04 g (39%) of the title compound. Analysis calculated by C? 7H23N304S:% C, 55.87; % H, 6.34; % N, 11.50. Found:% C, 55.97; % H, 6.28; % N, 11.20. Mass Spectrum Desorption Field: M = 365.

EXAMPLE 111 N-2- (4- (3-isoxazolyl) phenyl) propyl 2-propanesulfonamide A solution of 0.3 g (0.79 mmol) of material from the Example 108 and 0.079 mL of concentrated ammonia hydroxide was heated at 100 ° C for 2 hours. To the mixture was added 2 drops of concentrated ammonia hydroxide and the mixture was heated at 100 ° C for 18 hours. The mixture was cooled and partitioned between 5 L of water and 5 mL of ether. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ether. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (12 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.038 g (16%) of the title compound. • Analysis calculated by C15H20N2O3S:% C, 58.42; % H, 6.54; % N, 9.08. Found:% C, 58.28; % H, 6.67; % N, 8.78. Mass Spectrum Desorption Field: M = 308.

EXAMPLE 112 2-propanesulfonamide of N-2- (4- (3- (5- (2-hydroxy) ethyl) isoxazolyl) phenyl) propyl To a solution of 0.58 g (1.8 mmol) of material of Example 106A and 0.25 g (3.6 mmol) ) of 3-butin-1-ol in 3 mL of ethyl acetate and 1 drop of water was added 0.54 g (5.4 mmol) of potassium bicarbonate. The mixture was stirred at room temperature for 18 hours and then 3 drops of 3-butyn-1-ol were added and stirred for 2 hours and then 3 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 75% ethyl acetate / hexane) of the residue afforded 0.24 g (38%) of the title compound. Analysis calculated by C? 7H24N204S:% C, 57.93; % H. 6.86; % N, 7.95. Found:% C, 58.23; % H, 6.99; % N, 8.14. Mass Spectrum Desorption Field: M = 352.

EXAMPLE 113 2-propanesulfonamide of N-2- (4- (5- (3-bromo) isoxazolyl) phenyl) propyl A. N-2- (4-ethynylphenyl) propyl 2-propanesulfonamide: To a solution of 2.0 g (6.2 mmol) of material from Preparation 39 and 2.0 g (6.2 mmol) of tri-n-butylstannyl-ethyne in 20 mL of toluene was added 0.36 g (0.3 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled and filtered through diatomaceous earth and rinsed with 20 mL of ethyl acetate and concentrated in vacuo. Chromatography (100 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.3 g (18%) of the title compound.

B. To a solution of 0.3 g (1.1 mmol) of material from Example 113A and 0.1 g (0.5 mmol) of material from Preparation 45 in 2 mL of ethyl acetate and 1 drop of water, 0.17 g (0.7 mmol) was added. ) of potassium bicarbonate. The mixture was stirred at room temperature for 18 hours and then 0.1 g (0.5 mmol) of material from Preparation 45 was added and stirred for 5 hours and then 2 mL of water was added. The organic layer was separated, dried (MgSO), filtered and concentrated in vacuo. Chromatography (12 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.1 g (23%) of the title compound. Analysis calculated by C? 5H? 9BrN203? :% C, 46.52; % H, 4.94; % N, 7.23. Found:% C, 46.73; % H, 5.00; % N, 6.94. Mass Spectrum Desorption Field: M-l = 386.

EXAMPLE 114 N-2- (4- (2-pyridyl) phenyl) propyl 2-propanesulfonamide To a solution of 4.3 g (13.4 mmol) of material from Preparation 39 and 4.9 g (13.4 mmol) of 2- (tri-n-butylstannyl) pyridine in 10 mL of toluene was added 0.78 g. (0.67 mmoi) of Tetrakis (triphenylphosphamine) paiadium (0). The mixture was heated at 90 ° C for 18 hours. Then, 0.025 g (0.03 mmol) of bis (triphenylphosphamine) palladium (II) chloride was added and the mixture was heated at 90 ° C for 18 hours. The mixture was cooled and concentrated in vacuo. Chromatography (400 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 4.3 g (98%) of the title compound. Analysis calculated by C17H22N2OS * 0. H20:% C, 62.35; % H, 7.08; % N, 8.55. Found:% C, 62.05; % H, 6.78; % N, 8.23. Mass Spectrum Desorption Field: M = 318.

EXAMPLE 115 N-2- (4- (4-pyridyl) phenyl) propyl 2-propanesulfonamide To a solution of 1.0 g (3.1 mmol) of preparation material 39 and 1.1 g (3.1 mmol) of 4- (tri-n-butylstannyl) pyridine in 10 mL of dioxane was added 0.072 g (0.062 mmol) of Tetrakis ( triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. Then 0.1 g (0.08 mmol) of Tetrakis (triphenylphosphamide) palladium (0) and 0.5 g (1.5 mmol) of 4- (tri-n-butylstannyl) pyridine were added and the mixture was heated at 90 ° C for 18 hours. The mixture was cooled and filtered through diatomacea earth and rinsed with 10 mL ethyl acetate. The organic layer was dried (MgSO), filtered and concentrated in vacuo. The residue was suspended in 10 mL of dichloromethane and the solid was filtered off and washed with 10 mL of hexane to give 0.24 g (24%) of the title compound. Analysis calculated by C? 7H22N2023:% C, 64.12; % H, 6.96; % N, 8.80. Found:% C, 63.90; % H, 6.71; % N, 8.93. Mass Spectrum Desorption Field: M = 318.

EXAMPLE 116 N-2- (4- (3-pyridyl) phenyl) propyl 2-propanesulfonamide To a solution of 1.0 g (3.1 mmol) of preparation material 39 and 1.1 g (3.1 mmol) of 3- (tri-n-butylstannyl) pyridine in 10 mL of toluene was added 0.072 g (0.062 mmol) of Tetrakis ( trifeni1fasfamina) palladium (0). The mixture was heated at 90 ° C for 18 hours. Then 0.1 g (0.08 mmol) of Tetrakis was added (triphenylphosphamine) palladium (0) and 0.5 g (1.5 mmol) of 3- (tri-n-butylstannyl) pyridine and the mixture. it was heated at 90 ° C for 18 hours. The mixture was cooled and filtered through diatomaceous earth and rinsed with 10 mL ethyl acetate. The filtrate was concentrated in vacuo. Chromatography (75 g of silica gel, 75% ethyl acetate / hexane) of the residue afforded 0.43 g (44%) of the title compound. Analysis calculated by C 7 H 22 N 20 S * C 25 H 20:% C, 63.23; % H, 7.02; % N, 8.67. Found:% C, 63.31; % H, 7.04; % N, 8.01. Mass Spectrum Desorption Field: M - 318.

EXAMPLE 117 N-2- (4- (5-pyrimidinyl) phenyl) propyl 2-propanesulfonamide A. 5- (tri-n-butylstannyl) pyrimidine: A solution of 19.6 mL (31.4 mmol) of n-butyllithium 1.6M in 100 mL of ether was cooled to -100 ° C and a solution in the form of a drop of water was added. 5 g (31.4 mmol) of 5-bromo-irimidine in 20 mL of ether. The mixture was stirred at -78 ° C for 30 minutes then 8.5 mL (31.4 mmol) of tri-n-butylstannyl chloride in 20 mL of ether was added as a drop. The mixture was stirred for 30 minutes and then 100 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 30 mL each of ether. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (250 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 3.3 g (28%) of the title compound.

B. To a solution of 1.4 g (4.4 mmol) of material from Preparation 39 and 2.3 g (8.9 mmol) of material from Example 117A in 15 mL of dioxane was added 0.25 g (0.2 mmol) of Tetrakis (triphenylphosphamine) palladium ( 0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled and concentrated in vacuo. The residue was suspended in 10 mL of acetonitrile and the solid was filtered and washed with 5 mL of acetonitrile to provide 0.06 g (4%) of the title compound. Analysis calculated by C16H2? N302s:% C, 60.16; % H, 6.63,% N, 13.15. Found. % C, 60.18; % H, 6.62; '% N, 13.00. Mass Spectrum Desorption Field: M = 319 EXAMPLE 118 N-2- (4- (3-thienyl) phenyl) ethyl 2-propanesulfonamide To a solution of 1.0 g (3.3 mmol) of Preparation 47 material, 0.5 g (3.9 mmol) of thiophene-3-boronic acid and 0.7 g (4.9 mmol) of potassium carbonate in 8 mL of dioxane and 2 mL of water was added 0.18 g (0.16 mmol) of Tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 10 mL of water and 10 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, ethyl acetate / hexane to 35%) of the residue afforded 0.6 g (59%) of the title compound. Analysis calculated by CL5HI9N02S2:% C, 58.22; % H, 6.19; % N, 4.53. Found:% C, 58.30; % H, 5.96; % N, 4.48. Mass Spectrum Desorption Field: M = 309.

EXAMPLE 119 N-2- (4- (4-formylphenyl) phenyl) ethyl 2-propanesulfonamide To a solution of 4.0 g (13.3 mmol) of material from Preparation 47, 2.3 g (15.7 mmol) of 4-formyl-benzene-boronic acid and 2.7 g (19.6 mmol) of potassium carbonate in 32 mL of dioxane and 8 mL of water was added 0. g (0.6 mmol) of Terrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 5 hours. The mixture was cooled to room temperature and 40 mL of water and 40 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 20 mL each of ether. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (200 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 3.6 g (83%) of the title compound. Analysis calcined by C? 8H21N03S:% C, 65.23; % H, 6.39; % N, 4.23. Found:% C, 65.38; % H, 6.43; % N, 4.05. Mass Spectrum Desorption Field: M = 331.

EXAMPLE 120 N-2- (4- (4-hydroxymethylphenyl) phenyl) ethyl propanesulfonamide To a solution of 0.5 g (1.5 mmol) of Example 119 material in 20 mL of ethyl alcohol was added 0.056 g (1.5 mmol) of sodium borohydride. The mixture was stirred at room temperature for 2 hours and then 10 mL of ethyl acetate and 10 mL of water were added. The organic layer was separated and the aqueous layer was extracted twice with 5 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to give 0.5 g (100%) of the title compound. Analysis calculated by C18H23N03S:% C, 64.84; % H, 6.95; % N, 4.20. Found:% C, 64.74; % H, 6.92; % N, 4.36. Mass Spectrum Desorption Field: M = 333.

EXAMPLE 121 2-propanesulfonamide of N-2- (4- (4-N '- (2-propanesulfonylaniline) phenyl) ethyl A. 4-Bromo-N- (t-butoxycarbonyl) aniline: To a solution of 6.0 g (34.9 mmol) of 4-bromoaniline in 110 mL of tetrahydrofuran was added 70 mL (70 mmol) 1N sodium bis (trimethylsilyl) amide. . The mixture was stirred for 15 minutes and 7.6 g (34.9 mmol) of di-tert-butyl dicarbonate was added. The mixture was stirred for 18 hours and then concentrated in vacuo. The residue was partitioned between 120 mL of 10% aqueous sodium bisulfate and 120 mL of ethyl acetate. The organic layer was separated and washed twice with 50 mL each of brine. The organic layer was dried (MgSO), filtered and concentrated in vacuo. Chromatography (250 g of silica gel, 10% ethyl acetate / hexane) of the residue afforded 5.4 g (57%) of the title compound.

B. N-2- (4- (4-N'-t-butoxycarbonylaminophenyl) phenyl) t-butoxycarbonyl) propylamine: To a solution of 1.75 g (3.4 mmol) of material from Preparation 48 and 1.0 g (3.4 mmol) • Material of Example 121A in 10 mL of toluene was added 0. 2 g (0.17 mmol) of tetrakis (triphenylphosphamine) palladium (0) The mixture was heated at 100 ° C for 18 hours. The mixture was cooled and 10 mL of water was added. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (100 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.2 g (14%) of the title compound.

C. A solution of 0.2 g (0.48 mmol) of material from Example 121B in 4 mL of dichloromethane and 1 mL of trifluoroacetic acid was stirred at room temperature for 3 hours. The mixture was concentrated in vacuo and the residue was dissolved in 5 mL of dichloromethane and 0.15 mL (1.0 mmol) of 1,8-diazabicyclo [5.4.0] undec-7-ene was added. The solution was cooled to 0 ° C and added to a solution of 0.06 mL (0.5 mmol) of isopropylsulfonyl chloride in 1 mL of dichloromethane. The cold bath was stirred and the mixture was stirred at room temperature for 4 hours. The mixture was washed with 5 mL of 1N aqueous hydrochloric acid, the organic layer was separated and the aqueous layer was extracted three times with 5 mL of ethyl acetate. The combined organics were dried (MgSO), filtered and concentrated in vacuo. Chromatography (12 g of silica gel, 50% ethyl acetate / hexane) of the residue gave 0.005 g (2%) of the title compound. Mass Spectrum Desorption Field: M = 424.

EXAMPLE 122 N-2- (4- (4-cyanophenyl) phenyl) ethyl 2-propanesulfonamide To a solution of 1.7 g (3.4 mmol) of material from Preparation 48 and 0.6 g (3.4 mmol) of 4-bromobenzonitrile in 10 mL of toluene was added 0.2 g (0.17 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 100 ° C for 18 hours. The mixture was cooled and the solid was filtered and rinsed with 10 mL hexane to provide 0.4 g (36%) of the title compound. Analysis calculated by C18H2oN202S:% C, 65.83; % H, 6.14; % N, 8.53. Found:% C, 65.61; % H, 5.87; % N, 8.44. Mass Spectrum Desorption Field: M = 328.

EXAMPLE 123 2-propanesulfonamide of N-2- (4- (4-N ', N' - diethylamphenyl) phenyl) propyl A. 4-N, N-diethylaminobenzeneboronic acid: A solution of g (43.8 mmol) of 4-bromo-N, N-diethylaniline in 150 mL of tetrahydrofuran was heated to -78 ° C and 30 mL (48.2 mmol) of n-butyllithium 1.6M was added dropwise. The mixture was stirred at -78 ° C for 60 minutes, then 15.2 mL (65.7 mmol) of triisopropyl borate was added dropwise and then stirred for 60 minutes. The cooling bath was stirred and then 75 mL of water and 5N hydrochloric acid was added until pH = 6 and then stirred for 18 hours. The aqueous layer was separated and the organic layer was extracted twice with 25 mL each of 1N sodium hydroxide. The combined aqueous extracts were acidified with concentrated hydrochloric acid to pH = 7. The resulting solid was filtered and washed with 20 mL methyl alcohol at 2.8 g (33%) of the title compound.

B. To a solution of 0.5 g (1.6 mmol) of material of preparation 39, 0.36 g (1.9 mmol) of material of Example 123A and 0.33 g (2.4 mmol) of potassium carbonate in 4 mL of dioxane and 1 was added. mL of water 0.09 g (0.07 mmol) of tetrakis (triphenylphosphamine) palladium (O). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 10 mL of water and 5 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ether. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, ethyl acetate / hexane to 25%) of the residue afforded 0.38 g (61%) of the title compound.

Analysis calculated by C22H32N202S:% C, 68.00; % H, 8.30; % N, 7.21. Found:% C, 67.70; % H, 8.52; % N, 6.98. Mass Spectrum Desorption Field: M = 388.

EXAMPLE 124 N-2- (4- (2-fluorophenyl) phenyl) propyl 1-chloromethanesulfonamide A solution of 0.4 g (1.7 mmol) of material from preparation 6 and 0.27 ml (1.9 mmol) of triethylamine in 10 L of dichloromethane was cooled to 0 ° C. A solution of 0.15 mL (1.7 mmol) of methanesulfonyl chloride was added 1 mL of dichloromethane. The cold bath was stirred and the mixture was stirred at room temperature for 3 hours. The mixture was washed with 10 mL of 10% aqueous sodium bisulfate, the organic layer was separated and the aqueous layer extracted three times with 5 mL of dichloromethane / ether 1: 1. The combined organics were dried (MgSO4), filtered and concentrated in vacuo to give 0.60 g (100%) of the title compound. Analysis calculated by C? 6H? 7C? FN02S:% C, 56.22; % H. 5.01; % N, 4.10. Found:% C, 56.55; % H, 5.27; % N, 4.10. Mass Spectrum Desorption Field: M = 341.

EXAMPLE 125 2-propanesulfonamide of N-2- (4- (4- (1- (2- (2-propane) sulfonylamino) propyl) phenyl) phenyl) propyl To a solution of 1.3 g (2.5 mmol) of material from preparation 40 and 0.65 g (5.0 mmol) of 3-chloro-6-methylpyridazine in 10 mL of toluene was added 0.14 g (0.12 mmol) of tetrakis (triphenylphosphamine) palladium (0) The mixture was heated at 90 ° C for 18 hours. The mixture was cooled and filtered through diatomaceous earth and rinsed with 10 mL of ethyl acetate. The filtrate was concentrated in vacuo. Chromatography (50 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.20 g (33%) of the title compound. Analysis calculated by C2H36N20S:% C, 59.97; % H, 7.55; % N, 5.83. Found:% C, 59.67; % H, 7.55; % N, 5.97. Mass Spectrum Desorption Field: M-l = 479.

EXAMPLE 126 2-propanesulfonamide of N-2- (4- (4- (1- (2- (2-propane) sulfonylamino) ethyl) phenyl) phenyl) ethyl To a solution of 1.5 g (4.9 mmol) of material from Preparation 47 , 0.8 g (2.4 mmol) of hexamethylditin, and 0.6 g (14.7 mmol) of lithium chloride in 20 mL of dioxane were added 0.1 g (0.1 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled and filtered through diatomaceous earth and rinsed with 10 mL ethyl acetate. The filtrate was washed once with 10 mL of water and dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (75 g of silica gel, 50% ethyl acetate / hexane) of the residue gave 0.054 g (2.5%) of the title compound. Analysis calculated by C 22 H 32 N 204 S 2:% C, 58.38; % H, 7.13; % N, 6.19. Found:% C, 58.54; % H, 7.08; % N, 5.92. Mass Spectrum Desorption Field: M = 452.

EXAMPLE 127 2-propanesulfonamide of N-2- (4- (4- (1- (2-cyano) ethenyl) phenyl) phenyl) ethyl To a solution of 1.5 g (8.4 mmol) of diethylcyanomethyl phosphonate in 15 mL tetrahydrofuran was added 8.4 mL (8.4 ramol) 1M sodium bis (trimethylsilyl) amide. The mixture was stirred at room temperature for 30 minutes and then added to the material solution of Example 119 in 5 mL of tetrahydrofuran. The mixture was stirred for 1 hour and washed with 20 mL of water. The organic layer was separated and the aqueous layer extracted three times with 5 mL of ethyl acetate. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. The residue was suspended in 5 mL of dichloromethane and the resulting solid was filtered to provide 1.2 g (56%) of the title compound. The filtrate was concentrated in vacuo. Chromatography (100 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.5 g (23%) of the additional title compound. Analysis calculated by C 20 H 22 N 2 O 2 S:% C, 67.77; % H, 6.26; % N, 7.90. Found:% C, 67.50; % H, 6.21; % N, 7.73. Mass Spectrum Desorption Field: M = 354.

EXAMPLE 128 2-Propanesulfonamide hydrochloride N-2- (4- (4- (1- (3-amino) propyl) phenyl) phenyl) ethyl A solution of 0.47 g (1.3 mmol) of material from Example 127 and 0.32 g palladium on 5% carbon in 75 mL of ethyl alcohol and 3 mL of 5N hydrochloric acid was hydrogenated in a shaker for 60 psi of hydrogen and 50 °. C for 18 hours. The mixture was filtered and concentrated in vacuo. The residue was suspended in 10 mL of 1 N hydrochloric acid and filtered. Recrystallization of acetonitrile and methyl alcohol yielded 0.1 g (20%) of the title compound. Analysis calculated by C20H29N202S * 0.85HC1:% C, 61.20; % H, 7.67; % N, 7.14. Found:% C, 61.06; % H, 7.70; % N, 6.91. Mass Spectrum Desorption Field: M-l = 360.

EXAMPLE 129 2-propanesulfonamide of N-2- (4- (4- (1- (3- (2-propane) sulfonylamino) propyl) phenyl) phenyl) ethyl To a solution of 0.09 g (0.2 mmol) of material from Example 128 and 0.07 mmol (0.5 mmol) of triethylamine in 5 mL of dichloromethane was added 0.025 mL (0.2 mmol) of isopropylsulfonium chloride. The mixture was stirred at room temperature for 8 hours. The mixture was washed with 5 mL of 1N hydrochloric acid, the organic layer was separated and the aqueous layer extracted once with 5 L of ethyl acetate. The combined organics were dried (MgSO4), filtered and concentrated in vacuo to provide 0.050 g (53%) of the title compound. - Analysis calculated by C23H34N2O4S2 * 0.5CHC13:% C, 53.62; % H, 6.61; % N, 5.32. Found:% C, 53.18; % H, 6.78; % N, 4.97. Mass Spectrum Desorption Field: M = 466.

EXAMPLE 130 N-2- (4- (3-thienyl) phenyl) propylethanesulfonamide To a solution of 0.21 g (0.9 mmol) of material from preparation 53B and 0.15 mL (1.0 mmol) of 1,8-diazabicyclo [5.4.0] undec-7-ene in 5 mL of dichloromethane was added 0.10 mL (1.0 mmol) of 2-chloro-l-ethanesulfonyl chloride. The mixture was stirred at room temperature for 4 hours. The mixture was washed with 5 mL of 1 N hydrochloric acid, the organic layer was separated and the aqueous layer was extracted three times with 5 mL of ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 0.2 g (71%) of the title compound. Analysis calculated by C? 5 H 17 NO 2 S 2 * 0.2 CHCl 3:% C, 55.10; % H, 5.23; % N, 4.22. Found:% C, 55.40; % H, 5.10; % N, 4. 20. Mass Spectrum Desorption Field: M-l = 306.

EXAMPLE 131 Ede N-2- (4- (3-thienyl) phenyl) propylethanesulfonamide A solution of 0.024 g (0.078 mmol) of material from Example 130 and 5 mg of palladium or 5% char in 5 mL of ethyl acetate was degassed or gas-free three times under a hydrogen environment and stirred at room temperature. 4 hours. The mixture was filtered and concentrated in vacuo. The residue was recrystallized from ether and hexane to provide 0.024 g (99%) of the title compound. Analysis calculated by C? 5H? 9N02S2:% C, 58.22; % H, 6.19; % N, 4.53. Found:% C, 58.63; % H, 5.71; % N, 4.32. Mass Spectrum Desorption Field: M + l = 310.

EXAMPLE 132 2-propanesulfonamide of N-2- (4- (3-acetylphenyl) phenyl) propyl To a solution of 3.2 g (10.2 mmol) of preparation material 39, 2.0 g (12.2 mmol) of 3-acetylbenzeneboronic acid and 2.1 g (15.2 mmol) of potassium carbonate in 28 mL of dioxane and 7 mL of water were added. added 0.59 g (0.51 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 30 mL of water and 30 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 10 mL each of ether. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (150 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 2.4 g (66%) of the title compound. Analysis calculated by C2oH25N03S:% C, 66.82; % H, 7.01; % N, 3.89. Found:% C, 66.38; % H, 6.96; % N, 3.73. Mass Spectrum Desorption Field: M = 359.

EXAMPLE 133 2-propanesulfonamide of N-2- (4- (3- (1-hydroxyethyl) phenyl} phenyl) propyl To a solution of 0.5 g (1.4 mmol) of material from Example 132 in 5 mL of ethyl alcohol was added 0.05 g (1.4 mmol) of sodium borohydride. The mixture was stirred at room temperature for 2 hours, concentrated in vacuo and then 10 mL of ethyl acetate and 10 mL of water were added. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (40 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.3 g (65%) of the title compound. Analysis calculated by C 20 H 2 NO 3 S:% C, 66.40; % H, 7.53; % N, 3.87. Found:% C, 66.56; % H, 7.65; % N, 3.92. Mass Spectrum Desorption Field: M = 361.

EXAMPLE 134 N-2- (4- (2-benzothienyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.5 mmol) of preparation material 39, 0.3 g (1.9 mmol) of benzo [b] thiophene-2-boronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 4 mL of dioxane and 1 mL of water was added 0.09 g (0.08 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture is cooled to room temperature and 5 mL of water and 5 mL of ether and 10 mL of ethyl acetate are added. The mixture was concentrated in vacuo and the residue was dissolved in 10 mL of ethyl acetate and washed with 10 mL of brine. The organic layer was separated and dried (MgSO), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, ethyl acetate / 35% hexane) of the residue gave 0.08 g (14%) of the title compound. Analysis calculated by C20H23NO2S2 * 0.1 CHC13:% C, 62.40; % H, 6. 07; % N, 3. 63. Found:% C, 62. 63; % H, 6. 04; % N, 3. 63. Mass Spectrum Desorption Field: M = 373.

EXAMPLE 135 2-propanesulfonamide of N-2- (4- (3,4-dichlorophenyl) phenyl) propyl To a solution of 0.5 g (1.6 mmol) of preparation material 39, 0.4 g (1.9 mmol) of 3,4-dichlorobenzeneboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water was added 0.09 g (0.08 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of water and 5 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (75 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.52 g (86%) of the title compound. A second chromatography (40 g of silica gel, 35% ethyl acetate / hexane) of the title compound afforded 0.25 g (41%) of the title compound. Analysis calculated by C? 8H2? Ci2N02S:% C, 55.95; % H, 5.48; % N, 3.62. Found:% C, 56.22; % H, 5.28; % N, 3.56. Mass Spectrum Desorption Field: M-l '= 385.

EXAMPLE 136 N-2- (4- (4-methylphenyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of the material of Preparation 39, 0.25 g (1.9 mmol) of 4-benzeneboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water are added. added 0.09 g (0.08 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of water and 5 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (30 g of silica gel, ethyl acetate / hexane) of the residue afforded 0.42 g (82%) of the title compound. A second chromatography (25 g of silica gel, 35% ethyl acetate / hexane) of the title compound afforded 0.24 g (46%) of the title compound. Analysis calculated for d9H25N02S:% C, 68.80; % H, 7.60; % N, 4.20. Found:% C, 69.11; % H, 7.70; % N, 4.10. Mass Spectrum Desorption Field: M = 331.

EXAMPLE 137 N-2- (4- (4-chlorophenyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of the material of Preparation 39, 0.29 g (1.9 mmol) of 4-chlorobenzeneboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water, 0.09 g (0.8 mmol) of tetrakis (triphenylphosphamine) palladium (0) was added. The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of water and 5 L of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 3 mL each of ethyl acetate. The combined organic extracts were dried (MgSO), filtered and concentrated in vacuo. Chromatography (35 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.36 g of the title compound. The compound was recrystallized in -purity with ether to provide 0.36 g (65%) of the title compound. Analysis calculated for C? 8H22dN02S:% C, 61.40; % H, 6.30; % N, 3.98. Found:% C, 61.48; % H, 6.11; % N, 3.62, Mass Spectrum Desorption Field: M = 351.

EXAMPLE 138 N-2 (4- (2-methylphenyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of the material of Preparation 39, 0.25 g (1.9 mmol) of 2-methylbenzeneboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water are added. added 0.09 g (0.8 mmoi) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of water and 5 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 4 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (30 g of silica gel, 30% ethyl acetate / hexane) of the residue afforded 0.35 g (68%) of the title compound. Analysis calculated for C? 9H25N02S:% C, 68.8; % H, 7.60; % N, 4.20. Found:% C, 68.82; % H, 7.75; % N, 4.23. Mass Spectrum Desorption Field: M = 331.

EXAMPLE 139 N-2- (4- (3,5-dichlorophenyl) phenyl) propyl 2-propanoosulfonamide.

To a solution of 0.5 g (1.6 mmol) of the material of Preparation 39, 0.36 g (1.9 mmol) of 3,5-dichlorobenzeneboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water was added 0.09 g (0.8 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated to 90 ° C for 18 hours and then added 0. 36 g (1.9 mmol) of 3,5-dichlorobenzeneboronic acid. The mixture was cooled to room temperature and 10 mL of water and 10 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 5 mL each of aceLaLo from eLilo. The combined organic extracts are • dried (MgSO4), filtered and concentrated in vacuo. Chromatography (35 g of silica gel, ethyl acetate % / toluene) of the residue gave 0.36 g (60%) of the title compound. Analysis calculated for C? 9H2? NCl202S:% C, 55.90; % H, 5.50; % N, 3.60. Found:% C, 56.22; % H, 5.50; % N, 3.39. Mass Spectrum Desorption Field: M-l = 385.

EXAMPLE 140 N-2- (4- (4-trifluoromethylphenyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of the material of Preparation 39, 0.35 g (1.9 mmol) of 4-trifluoromethylbenzeneboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water are added. added 0.09 g (0.8 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of water and 5 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 4 L each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 20% ethyl acetate / hexane) of the residue afforded 0.40 g (67%) of the title compound. Analysis calculated for Ci9H22F3N02S:% C, 59.20; % H, 5.75; % N, 3.60. Found:% C, 59.14; % H, 5.67; % N, 3.34. Mass Spectrum Desorption Field: M = 385.

EXAMPLE 141 N-2- (4- (3-trifluoromethylphenyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of the material of Preparation 39, 0.35 g (1.9 rnmoi) of 3-trifluoromethylbenzeneboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 L of dioxane and 1 L of water are added. added 0.09 g (0.8 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of water and 5 mL of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 4 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 20% ethyl acetate / hexane) of the residue afforded 0.44 g (73%) of the title compound. Analysis calculated for C? 9H22F3N02S:% C, 59.20; % H, 5.75; % N, 3.60. Found:% C, 59.20; % H, 5.72; % N ', 3.62. Mass Spectrum Desorption Field: M = 385.

EXAMPLE 142 N-2- (4- (3-nitrophenyl) phenyl) propyl 2-propanesulfonamide To a solution of 0.5 g (1.6 mmol) of the material of Preparation 39, 0.31 g (1.9 mmol) of 3-nitrobenzanboronic acid and 0.3 g (2.3 mmol) of potassium carbonate in 5 mL of dioxane and 1 mL of water are added. added 0.09 g (0.8 mmol) of tetrakis (triphenylphosphamine) palladium (0). The mixture was heated at 90 ° C for 18 hours. The mixture was cooled to room temperature and 5 mL of water and 5 L of ether were added. The organic layer was separated and the aqueous layer was extracted three times with 4 mL each of ethyl acetate. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 35% ethyl acetate / hexane) of the residue afforded 0.40 g (71%) of the title compound. Analysis calculated for C? 9H22N20S:% C, 59.60; % H, 6.12; % N, 7.73. Found:% C, 59.59; % H, 6.07; % N, 7.74. Mass Spectrum Desorption Field: M = 362.

EXAMPLE 143 1- (2-methyl) -propaneosulfonamide of N-2- (4- (3-thienyl) phenyl) propyl A. Isobutylsulfonyl chloride: A solution of diisobutyldisulfide 13 g (73 mmol) in 100 mL of water was cooled to 0 ° C. Gaseous chlorine was pumped through the aqueous solution until a yellow solution persisted and then nitrogen gas was pumped through 15 minutes. The reaction mixture was diluted with 100 mL of ether and the organic layer was separated and the aqueous layer was extracted three times with 30 mL of ether. The combined organics were dried (MgSO), filtered and concentrated in vacuo. The residue was distilled to provide 12 g (52%) of the title compound.

B. To a solution of 0.5 g (2.3 mmol) of the material of Preparation 53B and 0.42 mL (3.0 mmol) of triethylamine in 10 mL of tetrahydrofuran was added 0.47 g (3.0 mmol) of the material of Example 143A. The mixture was stirred at room temperature for 18 hours. The mixture was washed with 20 mL of 1 N hydrochloric acid, the organic layer was separated and the aqueous layer was extracted three times with 5 mL of ether. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 30% ethyl acetate / hexane) of the residue afforded 0.6 g (77%) of the title compound. Analysis calculated for C? 7H23N02S2:% C, 60.50; % H, 6.87; % N, 4.15. Found:% C, 60.30; % H, 6.88; % N, 4.07. Mass Spectrum Desorption Field: M = 337.

EXAMPLE 144 N-2- (4- (2-benzothiazoli) phenyl) propyl 2-propanesulfonamide To a solution of 0.4 g (0.7 mmol) of the material from Preparation 40 and 0.13 g (0.7 mmol) of 2-chlorobenzothiazole in 5 mL of xylene, 0.016 g (0.02 mmoi) of dichlorobis (triphenylphosphamine) palladium (II) was added. . The mixture was heated at 120 ° C for 18 hours and 0.010 g (0.02 mmol) of dichlorobis (triphenylphosphamine) palladium (II) was added to the mixture and the mixture was heated at 120 ° C for 5 hours. The mixture was cooled and 20 mL of saturated potassium fluoride was added thereto, and the mixture was stirred for 1 hour. The mixture was filtered and the organic layer was stirred, dried (MgSO 4), filtered and concentrated in vacuo.

Chromatography (25 g of silica gel, 25% ethyl acetate / hexane) of the residue gave 0.03 g (1%) of the title compound. Analysis calculated for C? 9H22N202S2:% C, 60.93; % H, 5.92:% N, 7.48. Found:% C, 61.24; % H, 6.05; % N, 7.04. Mass Spectrum Desorption Field: M = 374.

EXAMPLE 145 N-2- (4- (2-fluorophenyl) phenyl) propyl 2-methoxyethanesulfonamide A solution of 0.5 g (1.6 mmol) of material from Example 8 in 5 mL of 2M ammonia in methyl alcohol was stirred at room temperature for 18 hours. To the solution, 2 mL of concentrated ammonia hydroxide was added and stirring continued for 5 hours. The mixture was concentrated in vacuo. Chromatography (25 g of silica gel, 50% ethyl acetate / hexane with 2% methyl alcohol) of the residue gave 0.03 g (5%) of the title compound.

Analysis calculated for Ci8H22FN03S:% C, 61. 52; % H, 6. 31; % N, 3.99. Found:% C, 65.02; % H, 6.17; % N, 4.06. Mass Spectrum Desorption Field: M = 351.

EXAMPLE 146 N-2- (4- (2-fluorophenyl) phenyl) ethyl trifluoromethanesulfonamide A solution of 1.0 g (3.0 mmol) of the material of Example 7C and 1.0 mL (7.6 mmol) of triethylamine in 10 mL of dichloromethane was cooled to 0 ° C and 0.32 mL (3.0 ramol) of trifluoromethanesulfonyl chloride was added. The mixture was stirred at 0 ° C for 1 hour. The mixture was washed with 10 mL of 10% sodium bisulfate, the organic layer was separated and the aqueous layer was extracted three times with 10 mL of dichloromethane. The combined organics were dried (MgSO4), filtered and concentrated in vacuo to provide 0.45 g (43%) of the LiLuio compound. Analysis calculated for C? 5H13F4N02:% C, 51.87; % H, 3.77; % N, 4.03. Found:% C, 53.45; % H, 3.91; % N, 4.15 Mass Spectrum Desorption Field: M = 347.

EXAMPLE 147 N-2- (4- (2-fluorophenyl) phenyl) propyl Trifluoromethanesulfonamide A stock solution of 0.53 g (2.3 mmol) of material from Preparation 6 was prepared in 26 mL of chloroform, and 1 mL was removed and added to a Tefion cap, 4 mL. To the flask was added 0.038 g (0.13 mmol) of poly (4-vinylpiperidine) cross-linked resin ai 2% and 11.5 μL (0.11 mmol) of trifluoromethanesulfonyl chloride. The flask was shaken at room temperature for 24 hours and then, 0.040 g (0.8 mmol) of aminomethyl polystyrene was added and the flask shaken for 8 hours. The reaction mixture was filtered through a cotton plug and the filtrate was concentrated in vacuo to give the title compound. The NMR was consistent with the proposed compound. XH NMR 300MH2 (CDC13) d = 1.3 (d).

EXAMPLE 148 N-2- (4- (2-fluorophenyl) phenyl) propyl trifluoroethanesulfonamide The title compound was prepared following the method of Example 147 and using 12.2 μL (0.11 mmol) of 2,2,2-trifluoroethanesulfonyl chloride.

The NMR was consistent with the proposed compound. XE NMR (CDC3) d = 3.9 < ).

EXAMPLE 149 N-2- (4- (2-fluorophenyl) phenyl) propyl benzenesulfonamide The title compound was prepared following the method of Example 147 and using 14.0 μL (0.11 mmol) of benzenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 370.

EXAMPLE 150 N-2- (4- (2-fluorophenyl) phenyl) propyl 4-fluorobenzenesulfonamide The title compound was prepared following the method of Example 147 and using 21 mg (0.11 mmol) of 4-fluorobenzenesulfonyl chloride. The NMR was consistent with the proposed compound. A NMR (CDC3) d = 4.3 (m).

EXAMPLE 151 2-propanesulfonamide of N-2- (4- (4- (2-ethanesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 7.6 μL (0.11 mmol) of ethanesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M-l = 451.

EXAMPLE 152 2-propanesulfonamide of N-2- (4- (4- (2- (1-propanesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 9.0 μL (0.11 mmol) of 1-propane-sulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocio: M-l = 465.

EXAMPLE 153 2-propanesulfonamide of N-2- (4- (4- (2- (1-butanesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 10.4 μL (0.11 mmol) of 1-butansuifonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M-l = 479.

EXAMPLE 154 2-propanesulfonamide of N-2- (4- (1- (2- (1S-10-camphorsulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a solution stock of 0.5 g (1.4 mmol) of the material of Example 50 and 20 mg (0.11 mmol) of lS-10-camphorsulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M-l = 573.

EXAMPLE 155 2-propanesulfonamide of N-2- (4- (1- (2- (1R-10-camphorsulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 20 mg (0.11 mmol) of lR-10-camphorsuifonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M-l = 573.

EXAMPLE 156 2-propanesulfonamide of N-2- (4- (1- (2- (2-methoxycarbonylethanesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 15 mg (0.11 mmol) of 2-carboxymethoxy-ethanesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: [M + H20] = 528.

EXAMPLE 157 2-propanesulfonamide of N-2- (4- (1- (2- (2-trifluoroethanesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 8.8 μL (0.11 mmol) of 2,2-trifiuoro-ethanesulfonyl chloride.

The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M-l = 505.

EXAMPLE 158 2-propanesulfonamide of N-2- (4- (1- (2-benzenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 14 mg (0.11 mmol) of benzenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M-l = 499.

EXAMPLE 159 2-propanesulfonamide of N-2- (4- (1- (2-benzylsulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 15 mg (0.11 mmol) of a-toluenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M-l = 513.

EXAMPLE 160 2-propanesulfonamide of N-2- (4- (1- (2-cyclohexanesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 15 mg (0.11 mmol) of cyclohexanesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M-l = 505.

EXAMPLE 161 2-propanesulfonamide of N-2- (4- (4- (2- (2-fluorobenzenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 15 mg (0.11 mmol) of fluorobenzenesuiphenyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M-l = 517.

EXAMPLE 162 2-propanesulfonamide of N-2- (4- (4- (2- (3-trifluoromethylbenzenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 19 mg (0.11 mmol) of 3-trifluoromethyl-benzenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M-l = 567.

EXAMPLE 163 2-propanesulfonamide of N-2- (4- (4- (2- (4-fluorobenzenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 15 mg (0.11 mmol) of 4-fluorobenzenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocio: M-l = 517.

EXAMPLE 164 2-propanesulfonamide of N-2- (4- (4- (2- (2-thiophenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 14 mg (0.11 mmol) of 2-thiophenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass spectrum electrorocium: M-l = 505.

EXAMPLE 165 2-propanesulfonamide of N-2- (4- (4- (2- (4-methoxybenzenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 16 mg (0.11 mmol) of 4-methoxybenzenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M-l = 529.

EXAMPLE 166 2-propanesulfonamide of N-2- (4- (4- (2- (4-trifluoromethyl-benzenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 20 mg (0.11 mmol) of 4-trifluoromethiibenzenesulfonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M-l = 567.

EXAMPLE 167 2-propanesulfonamide of N-2- (4- (4- (2- (1- (5-dimethylamino) afthalenesulfonylamino) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.5 g (1.4 mmol) of the material of Example 50 and 22 mg (0.11 mmol) of dansyl chloride. The NMR was consistent with the proposed compound. Electrorocium "of Mass Spectrum: M-l = 594.

EXAMPLE 168 2-propanesulfonamide of N-2- (4- (4- (2- (benzamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 15 μL (0.11 mmol) of benzoyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 465.

EXAMPLE 169 2-propanesulfonamide of N-2- (4- (1- (2- (3-methylbutanamido) -ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 13 μL (0.11 mmol) of valeryl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M + l = 455.

EXAMPLE 170 2-propanesulfonamide of N-2- (4- (4- (2- (4-fluorobenzamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 13 μL (0.11 mmol) of fluorobenzoyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 483.

EXAMPLE 171 2-propanesulfonamide of N-2- (4- (4- (2- (3-methoxybenzamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 18 mg (0.11 mmol) of methoxybenzoyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 495.

EXAMPLE 172 2-propanesulfonamide of N-2- (4- (4- (2- (2-thiophenamide) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 11 μL (0.11 mmol) of thiophenecarbonyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocy: M + l = 471.

EXAMPLE 173 2-propanesulfonamide of N-2- (4- (4- (2- (3-fluorobenzamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 13 μL (0.11 mol) of 3-fluorobenzoyl chloride. The NMR was consistent with the proposed compound.

Mass Spectrum Electrorocium: M + l = 483, EXAMPLE 174 2-propanesulfonamide of N-2- (4- (4- (2- (4-methoxybenzamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 13 μL (0.11 mmol) of methoxybenzoyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 495.

EXAMPLE 175 2-propanesulfonamide of N-2- (4- (4- (2- (2-methylpropanoamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 11 μL (0.11 mmol) of isobutyryl chloride.

The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 431.

EXAMPLE 176 2-propanesulfonamide of N-2- (4- (4- (2- (2-methoxybenzamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 16 μL (0.11 mmol) of methoxybenzoyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 495.

EXAMPLE 177 2-propanesulfonamide of N-2- (4- (4- (2- (phenylacetamido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 14 μL (0.11 mmol) of phenylacetyl chloride. The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 479.

EXAMPLE 178 2-propanesulfonamide of N-2- (4- (4- (2- (acaramido) ethyl) phenyl) phenyl) propyl The title compound was prepared following the method of Example 147 and using 1 mL of a stock solution of 0.6 g (1.8 mmol) of the material of Example 50 and 8 μL (0.11 mmol) of acetyl chloride. • The NMR was consistent with the proposed compound. Mass Spectrum Electrorocium: M + l = 401.

EXAMPLE 179 2-propanesulfonamide of N-2- (4-N- (benzamido) phenyl) propyl A solution of the material from Preparation 60 (333 mg, 0.93 mmol) in dichloromethane (5 ml) was treated with benzoyl chloride (197 mg, 1.4 mmol) and triethylamine (140 mg, 1.4 mmol). The reaction mixture was stirred at room temperature for 3 hours. Water (10 ml) was added to the mixture and the organic extracted with ether (3X10 ml). The combined organic fraction was washed with brine (10 ml), dried over sodium sulfate, and concentrated in vacuo to give the crude product which was further purified by flash chromatography (Si02, EtOAc: 30% Hexanes). The pure product was treated with trifluoroacetic acid: dichloromethane (5 mL, 1: 1 mixture). The mixture was stirred at room temperature for 1 hour. Water (10 mL) was added to the mixture and the organic fraction was extracted with dichloromethane (3X10 mL). The organic fraction was washed with water (2X10 ml), brine (10 ml), dried over sodium sulfate, and concentrated in vacuo to give 248 mg (74%) of the title compound. The NMR was consistent with the structure of the proposed title. Field of Desorption of Mass Spectrum: M + = 360. Analysis for C? 9H24N2Ü3S: Theory: C, 63.31; H, 6.71; N, 7.77 Found: C, 63.17; H, 6.67; N. 7.73 EXAMPLE 180 2-propanesulfonamide of N-2- (4- (N- (acetamido) phenyl) propyl.

The title compound 118 mg (75%) was prepared as a solid following the method of Example 179, starting from the product of Preparation 60 and using acetyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 360. Analysis for C? H22N203S: Theory: C, 56.35; H, 7.43; N, 9.39 Found: C, 57.36; H, 7.98; N, 10.40 EXAMPLE 181 2-propanesulfonamide of N-2- (4- (N- (2-fluorobenzamido) phenyl) propyl.

The title compound 160 mg (75%) was prepared as a solid following the method of Example 179, starting from the product of Preparation 60 and using 2-fluorobenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 378. 3 7 Analysis for Ci9H23FN203S: Theory: C, 60.30; H, 6.13; N, 7.40 Found: C, 59.51; H, 5.98; N, 7.11 EXAMPLE 182 2-propanesulfonamide of N-2- (4- (N- (2-furylcarboxamido) phenyl) propyl.

The title compound 150 mg (47%) was prepared as a solid following the method of Example 179, starting from the product of Preparation 60 and using 2-furoiium chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 352.3 Cisalysis for C17H22N20S: Theory: C, 58.29; H, 6.33; N, 7.99 Found: C, 58.19; H, 6.81; N, 7.25 EXAMPLE 183 2-propanesulfonamide of N-2- (4- (N- (2-thienylcarboxamido) phenyl) propyl.

The title compound 150 mg (33%) was prepared as a solid following the method of Example 1, starting from the product of Preparation 7 and using 2-thiophene chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 366.2 Analysis for C? 7H22N2? 3S2: Theory: C, 55.71; H, 6.05; N, 7.64 Found: C, 55.59; H, 5.01; N, 7.80.

EXAMPLE 184 2-propanesulfonamide of N-2- (4- (N- (4-vinylbenzamido) phenyl) propyl.

The title compound 420 mg (56%) was prepared as a solid following the method of Example 179, starting from the product of Preparation 60 and using 4-vinylbenzoium chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 387 .2 Analysis for C2? H24N2? 3S: Theory: C, 65.26; H, 6.78; N, 7.25 Found: C, 64.99; H, 6.69; N, 7.17 EXAMPLE 185 2-propanesulfonamide of N-2- (4-N- (4-iodobenzamido) phenyl) propyl.

The title compound 610 mg (73%) was prepared as a solid following the method of Example 179, starting from the product of Preparation 60 and using 4-iodobenzoyl chloride. The NMR ± ue consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 487.2 7 Analysis for Ci9H23203S: Theory: C, 46.91; H, 4.73; N, 5.76 Found: C, 47.13; H, 4.51; N, 5.60 EXAMPLE 186 2-propanesulfonamide of N-2- (4- (4-N- (1- (2- (2-propane) sulfonylamino) propylbenzamido) phenyl) propyl At 0 ° C a solution of the Preparation material 67 (210 mg, 0.77 mmol) in dry acetone (5 ml) was treated with N-methylmorpholine (120 mg, 1.2 mmol) and i-butyl chloroformate (120 mg, 0.85 mmol). The reaction mixture was stirred for 30 minutes. The solvent was red and the resulting solid was dissolved in DMF (5 ml). The mixture was treated with aniline from Preparation 58 (220 mg, 0.85 mmol). The reaction mixture was stirred at room temperature for 16 hours. Water (10 mL) was added to the mixture and the organic extracted with dichloromethane (3X10 mL). The combined organic fraction was washed with water (2X10 ml), Brine (10 ml), dried over sodium sulfate, and concentrated to give the crude product which was further purified by flash chromatography (Si02, EtOAc: 30% Hexane) to provide 100 mg (25%) of the pure product . The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 509. 8 Analysis for C24H35N3? 5S2: Theory: C, 56. 78; H, 6. 55; N, 8 .28 Found: C, 56.71; H, 6.64; N, 8.01 EXAMPLE 187 2-propanesulfonamide of N-2- (4-N- (cyclohexanecarboxamido) phenyl) propyl A solution of the material of Preparation 58 (20 mg, 0.08 mmol) in dry THF (1 ml) in a 4 ml Teflon capped flask was treated with a crosslinked 2: 2 poly (4-vinylpyridine) resin (200 mg, 1.6 mmol) and appropriate hydrochloric acid. (1.2 equivalents, 0.096 mmol). The flask was shaken at room temperature for 24 hours. The reaction was filtered through an ion exchange column (0.5 pre-packed SCX 1211-3039) to remove the unreacted aniline. The aminomethyl-polystyrene (400 mg, 0.8 mmol) was added to the filtrate and the mixture was shaken at room temperature for 24 hours. The reaction mixture was filtered through a cotton plug and the filtrate was concentrated to give the pure amide. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 366.3 EXAMPLE 188 2-propanesulfonamide of N-2- (4-N- (4-fluorobenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-fluorobenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 378.2 EXAMPLE 189 2-propanesulfonamide of N-2- (4- (N- (3-methylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 3-methylbenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 374.2 EXAMPLE 190 2-propanesulfonamide of N-2- (4- (N- (3-trifluoromethylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 3-methylbenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 428.2 EXAMPLE 191 2-propanesulfonamide of N-2- (4- (N- (2-trifluoromethylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 2-trifluoromethylbenzoyl chloride. The NMR ± ue consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 428.2 EXAMPLE 192 2-Propanesulfonamide of N-2- (4- (N- (3-fluorobenzamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using chloride of 3-fluorobenzoyl The NMR was consistent with the structure of the proposed title: Mass Spectrum Desorption Field: M + = 378.2 EXAMPLE 193 2-propanesulfonamide of N-2- (4- (N- (2-methoxybenzamido) ± enyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 2-methoxybenzoyl chloride.

The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 390. 2 EXAMPLE 194 2-propanesulfonamide of N-2- (4- (N- (3-methoxybenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 3-methoxybenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 390.2 EXAMPLE 195 2-propanesulfonamide of N-2- (4- (N- (4-t-butylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-t-butylbenzoyl chloride.

The NMR ± ue consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 416. 2 EXAMPLE 196 2-propanesulfonamide of N-2- (4- (N- (2, 4-difluorobenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 2,4-difluorobenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 396.2 EXAMPLE 197 2-propanesulfonamide of N-2- (4- (N- (4-methoxybenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-methoxybenzoyl chloride.

The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 390. 2 EXAMPLE 198 2-propanesulfonamide of N-2- (4- (N- (4-ethylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-ethylbenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 388.2 EXAMPLE 199 2-propanesulfonamide of N-2- (4- (N- (cyclobutylcarboxamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using cyclobutanecarbonyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 338.2 EXAMPLE 200 2-propanesulfonamide of N-2- (4- (N- (phenylacetamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using phenylacetyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 374.2 EXAMPLE 201 2-propanesulfonamide of N-2- (4- (N- (4-methylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-methylbenzoyl chloride. The NMR ± ue consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 374.2. EXAMPLE 202 2-Propanesulfonamide of N-2- (4-N-3- (5-methyl) isoxazolyl) carboxamide) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 5-methyl-3-isoxazole acid chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 365.2 EXAMPLE 203 2-propanesulfonamide of N-2- (4-N- ((2-fluoro-4-trifluoromethyl) benzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 2-fluoro-4- (tri-luorometii) benzoyl chloride. The NMR is consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 466.1 EXAMPLE 204 2-propanesulfonamide of N-2- (4-N- (4-trifluoromethylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4- (trifluoromethyl) benzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 444.1 EXAMPLE 205 2-propanesulfonamide of N-2- (4-N- (4-b-butyloxybenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-n-butyloxybenzoyl chloride. The NMR ± ue consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 432.2 EXAMPLE 206 2-propanesulfonamide of N-2- (4-N- (cyclopropylcarboxamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using cyclopropanecarbonyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 324.2 EXAMPLE 207 N-2- (4-N- (cyclopentylcarboxamido) phenyl) propyl 2-propanesulfonamide.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using cyclopentanecarbonyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 353 EXAMPLE 208 N-2- (4-N- (ethylcarboxamido) phenyl) propyl 2-propanesulfonamide.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using propionyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 312 EXAMPLE 209 N-2- (4-N- (propylcarboxamido) phenyl) propyl 2-propanesulfonamide.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using butanoyl chloride. The NMR was consistent with the structure of the proposed title.

Mass Spectrum Desorption Field: M + = 326 EXAMPLE 210 2-propanesulfonamide of N-2- (4-N- (5-isoxazolylcarboxamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 5-isoxazole chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 351 EXAMPLE 211 2-propanesulfonamide of N-2- (4-N- (2-benzothiophenylcarboxamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 2-benzothiophene chloride. The NMR was consistent with the structure of the proposed title.

Mass Spectrum Desorption Field: M + = 416 EXAMPLE 212 2-propanesulfonamide of N-2- (4-N- (4-phenylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-phenylbenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 436 EXAMPLE 213 2-propanesulfonamide of N-2- (4-N- (4-propylbenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-propylbenzoyl chloride.

The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 402 EXAMPLE 214 2-propanesulfonamide of N-2- (4-N- (4-cyanobenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-cyanobenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 385 EXAMPLE 215 2-propanesulfonamide of N-2- (4-N- (2-thiophenylacetamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 2-thiopheneacetyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = '380.

EXAMPLE 216 2-propanesulfonamide of N-2- (4-N-4- (3-phenyl) isoxazolyl) -carboxamidophenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 3-phenyl-5-methyl-4-isoxazole chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 441 EXAMPLE 217 2-propanesulfonamide of N-2- (4-N- (4-morpholinecarboxamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-morpholinecarbonyl chloride. The NMR ± ue consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 369 EXAMPLE 218 N-2- (4-N- (isonicotinylamido) phenyl) propyl 2-propanesulfonamide.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using isonicotinoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 361.

EXAMPLE 219 2-propanesulfonamide of N-2- (4-N- (3-chlorobenzamido) phenyl) propyl.

The title compound- was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 3-chlorobenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 395 EXAMPLE 220 2-propanesulfonamide of N-2- (4-N- (4-bromobenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-bromobenzoyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 439.4 EXAMPLE 221 2-propanesulfonamide of N-2- (4-N- (4-chlorobenzamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 4-chlorobenzoyl chloride.

The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 395.

EXAMPLE 222 N-2- (4-N- (methyloxalylamido) phenyl) propyl 2-propanesulfonamide.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using methyloxalyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 343 EXAMPLE 223 2-propanesulfonamide of N-2- (4-N- (phenoxyacetamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using phenoxyacetyl chloride. The NMR was consistent with the structure of the proposed title.

Mass Spectrum Desorption Field: M + = 391 EXAMPLE 224 N-2- (4-N- (acryloylamido) phenyl) propyl 2-propanesulfonamide.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using acryloyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 311 EXAMPLE 225 2-propanesulfonamide of N-2- (4-N- (5-nitro-2-furylcarboxamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 5-nitro-2-furyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 396 EXAMPLE 226 2-propanesulfonamide of N-2- (4-N- (6-chloronicotinylcarbamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 6-chloronicotinyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 396 EXAMPLE 227 2-propanesulfonamide of N-2- (4-N- (piconioylcarbamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using picoyl ioyl chloride. The NMR was consistent with the structure of the proposed title.

Mass Spectrum Desorption Field: M + = 362 EXAMPLE 228 2-propanesulfonamide of N-2- (4-N- (2- (S) - (-) - N- (trifluoroacetyl) pyrrolidinylcarboxamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using (S) - (-) - N- (trifluoroacetyl) prolyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 450 EXAMPLE 229 2-propanesulfonamide of N-2- (4-N- (pivaloylcarbamido) phenyl) propyl.

The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using pivaloyl chloride. The NMR was consistent with the structure of the proposed title.

Mass Spectrum Desorption Field: M + = 341 EXAMPLE 230. 2-propanesulfonamide of N-2- (4-N- (3-acetylphenylurea) phenyl) propyl A solution of the material of Preparation 58 (15 mg, 0.058 mmol) in dry THF (1 ml) in a 4 ml Teflon capped bottle was treated with 3-acetylphenylisocyanate (12 mg, 0.073 mmol). The reaction mixture was shaken for 16 hours. Aminomethyl polystyrene resin (150 mg, 0.3 mmol) was added to the reaction mixture and this mixture was allowed to stir for 2 hours. The reaction was filtered through an ion exchange column (0.5 pre-packed SCX 1211-3039) to remove the unreacted aniline. The reaction mixture was filtered through a cotton plug and the filtrate was concentrated to give 32 mg of the pure amide. The NMR was consistent with the structure of the proposed title.

Mass Spectrum Desorption Field: M + = 417.5 EXAMPLE 231 2-propanesulfonamide of N-2- (4-N- (2- (2-thienyl) ethylurea) phenyl) propyl A solution of the material of Preparation 58 (15 mg, 0.058 mmol) in dry THF (1 ml) in a 4 ml Teflon capped bottle with 2 (thien-2-yl) ethylisocyanate (12 mg, 0.073 mmol). The reaction mixture was shaken for 16 hours. Aminomethyl polystyrene resin (150 mg, 0.3 mmol) was added to the reaction mixture and this mixture was allowed to stir for 2 hours. The reaction was filtered through an ion exchange column (0.5 pre-packed SCX 1211-3039) to remove the unreacted aniline. The reaction mixture was filtered through a cotton plug and the filtrate was concentrated to give 26.5 pure amide. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 409.6 EXAMPLE 232 2-propanesulfonamide of N-2- (4- (4-N-benzylpiperazino) phenyl) propyl A solution of the material of Preparation 73 (80 mg, 0. 18 mmol) in dry tetrahydrofuran (10 ml) was treated with borane methylsulfide (1M in THF, 3 ml, 3 mmol), the mixture • Reaction was stirred while refluxing for 4 hours. The solution was cooled down to room temperature and treated with 5N sodium hydroxide (5 ml) and methanol (5 ml). The mixture was refluxed for 12 hours. The reaction mixture was cooled to room temperature and water (10 ml) was added to the mixture. The organic was extracted with dichloromethane (3X10 ml). The combined organic fraction was washed with water (2X10 ml), brine (00 ml), dried over potassium carbonate, and concentrated in vacuo to give the crude material, which was further purified by flash chromatography (SIO2, dichloromethane: EtOAc 30%) to give 34 mg (45%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 436. Analysis for C23H33N3OS: Theory: C, 66.47; H, 8.00; N, 10.11 Found: C, 65.72; H, 7.89; N, 9.68 EXAMPLE 233 2-propanoposulfonamide of N-2- (4- (4-methylpiperazino) phenyl) propyl A solution of the material of Preparation 72 (80 mg, 0.18 mmol) in formic acid (0.7 ml) was treated with formaldehyde (0.7 ml, 37%). The reaction mixture was heated to 80 ° C for 1 hour and then cooled to room temperature. Water (10 ml) was added to the mixture. The pH of the mixture was brought to 10 by the addition of 1N sodium hydroxide. The organic was extracted with ethyl acetate (3X10 ml). The combined organic fraction was washed with water (2X10 ml), brine (10 ml), dried over potassium carbonate, and concentrated in vacuo to give the crude material, which was further purified by flash chromatography (Si02, methanol: dichloromethane to 10%) to give 46 mg (75%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 436. Analysis for Ci7H29N302S: Theory: C, 60.14; H, 8.61; N, 12.38 Found: C, 59.31; H, 8.57; N, 11.58 EXAMPLE 234 N-2- (4- (2-thienyl) methylaminophenyl) propyl 2-propanesulfonamide A solution of the product from Preparation 58 (0.15 g, 0.42 mmol) in methanol (3 ml) and glacial acetic acid (1 drop) was treated with 2-thiophenecarboxaldehyde (0.031 g, 0.28 mmol). The reaction was stirred at room temperature for 90 minutes and sodium borohydride (0.015 g, 0.42 mmol) was added. The reaction was stirred for 16 hours. Water (5 ml) was added and the organic was extracted with methylene chloride (2X10 ml). The combined organic layers were washed with brine, dried over magnesium sulfate and concentrated. The crude product was dissolved in methylene chloride (3 ml) and THF (5 drops) was added. The reaction was stirred for 3 hours at room temperature, then added (3 ml). The organic was extracted with methylene chloride (2X10 ml).

The combined organic layers were washed with brine, dried over magnesium sulfate and concentrated. The crude product was purified by flash chromatography (Si02, EtOAc: 30% Hexanes) to give 0.060 g (60%) of the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 353. Analysis for CX7H24N202S: Theory: C, 57.92; H, 6.86; N, 7.95 Found: C, 58.11; H, 6.71; N, 7.79 EXAMPLE 235 2-Propanesulfonamide of N-2- (4- (2-furyl) methylaminophenyl) propyl The title compound 80 mg (85%) was prepared as an oil following the method of Example 234, from the material of Preparation 58 and using 2-furaldehyde. The NMR was consistent with the structure of the proposed title of the Mass Spectrum Desorption Field: M + = 336 Analysis for C? 7H2N203S: Theory: C, 60.69; H, 7.19; N, 8.33 Found: C, 60.52; H, 7.03; N, 8.45 EXAMPLE 236 N-2- (4- (3-thienyl) methylaminophenyl) propyl 2-propanesulfonamide The title compound 70 mg (54%) was prepared as an oil following the method of Example 234, starting from the product of Preparation 58 and using 3-thiophenecarboxaldehyde. The NMR was consistent with the structure of the proposed title. Field of Spectrum of Mass Spectrum: M + = 336.1 Analysis for C? 7H2N? 3S: Theory: C, 60.69; H, 7.19; N, 8.33 Found: C, 60.89; H, 7.16; N, 8.09 EXAMPLE 237 N-2- (4- (3-furyl) methylaminophenyl) propyl 2-propanesulfonamide The title compound 40 mg (21%) was prepared as an oil following the method of Example 234, starting from the product of Preparation 58 and using 3-furaldehyde. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 352 Analysis for C? 7H2 2? 3S: Theory: C, 57.92; H, 6.86; N, 7.95 Found: C, 57.80; H, 6.63; N, 7.78 EXAMPLE 238 2-propanesulfonamide of N-2- (4- (2-fluorophenyl) methylamino) phenyl) propyl The title compound 52 mg (52%) was prepared as an oil following the method of Example 234, starting from the product of Preparation 58 and using 2-fluoro-benzaldehyde. The NMR was consistent with the structure of the proposed title. Destroying Field of Mass Spectrum: M + = xxx. • Analysis for C? 9H25FN202S: EXAMPLE 239 N-2- (4-morpholinophenyl) propyl 2-propanesulfonamide The title compound 70 mg (47%) was prepared as an oil following the method of Example 65, starting from the product of Preparation 39 (part 1) and using morpholine. The NMR was consistent with the structure of the proposed title. Destroying Field of Mass Spectrum: M + = xxx. Analysis for C? 6H26N203S: EXAMPLE 240 2-propanesulfonamide of N-2- (4- (2-fluorophenyl) methoxyphenyl) propyl A solution of the product of Preparation 36 (0.3 g, 0.84 mmol) in dry DMF (20 ml) was treated with sodium hydride (0.037 g) 0.92 mmol) and 2-fluorobenzyl bromide (0.17 g, 0.92 mmol) The reaction mixture was stirred at room temperature for 5 hours, water (10 ml) was added and the organic was extracted with ether (2X30 ml). The combined organic extracts were washed with brine (20 ml), dried over magnesium sulfate, and concentrated in vacuo, the crude material was taken up in methylene chloride (20 ml) and TFA (2 ml) was added. to ambient for 3 hours Water (5 ml) was added and the organic was extracted with methylene chloride (2X20 ml) The combined organic layers were washed with brine (20 ml), dried over magnesium sulfate, and concentrated in vacuo. The crude product was further purified by flash chromatography (Si02, EtOAc: 30% Hexanes) to give 0.25 g (82%) of a white solid as a pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 365. Analysis for C? 9H24FN3S: Theory: C, 62.44; H, 6.62; N, 3.83 Found: C, 62.44; H, 6.59; N, 3.76 EXAMPLE 241 N-2- (4- (2-tetrahydrofuryl) methoxyphenyl) propyl 2-propanesulfonamide The title compound 150 mg (52%) was prepared as a solid following the method of Example 240, starting from the product of Preparation 36 and using tetrahydrofurfuryl bromide. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 341.1 Analysis for C? 7H27N04S: Theory: C, 59.80; H, 7.97; N, 4.10 Found: C, 59.84 H, 8.00; N, 3.80 EXAMPLE 242 N-2- (4-benzoylmethylphenyl) propyl 2-propanesulfonamide A solution of the product of Preparation 39 (1.0 g, 3.2 mmol) in degassed or gas free, dry tetrahydrofuran (25 ml) was treated with palladium chloride (0.028 g, 0.16 mmol), tri-o-tolylphosphamine (0.097 g). g, 0.32 mmol), tributyl-fluoride tin (1.0 g, 3.4 mmol), and 1-phenyl-1- (trimethylsiloxy) ethylene (1.0 mL, 4.8 mmol). The reaction mixture was heated to reflux for 16 hours. Water was added (50 ml) to the mixture and the organic layer was extracted with ether (3X50 ml). The combined organic layers were washed with brine (50 ml), dried over magnesium sulfate, and concentrated in vacuo to give the crude product which was further purified by flash chromatography.

(Si02, EtOAc: 30% Hexanes) to give 0.28 g (24%) of a solid as a pure product. The NMR was consistent with the structure of the proposed title. Ion dew of Mass Spectrum: M + l = 360.0, M-l = 358.0 Analysis for C2oH25 03S: Theory: C, 66.82; H, 7.01; N, 3.90 Found: C, 66.86; H, 7.16; N, 3.85 EXAMPLE 243 N-2- (4-acetylphenyl) propyl 2-propanesulfonamide A solution at -80 ° C, from the product of Preparation 39 (2.0 g, 6.4 mmol) in dry THF (30 ml) was treated slowly with a solution of nBuLi (8.0 ml, 13.5 mmol), 1.7M solution in hexanes). The reaction was stirred at -80 ° C for 30 minutes and then treated with dimethylactamide (0.6 ml, 12.8 mmol). The reaction was treated with a saturated, aqueous solution of ammonia chloride at -80 ° C (2 ml). Water (30 ml) was added to the mixture and the organic layer was extracted with ether (2 × 50 ml). The combined organic layers were washed with brine (50 ml), dried over magnesium sulfate and concentrated. The crude product was further purified by flash chromatography (Si02, 30% EtOAc: hexanes) to give 1.0 g (55%) of a solid as the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 283.0 Analysis for C? H21N03S: Theory: C, 59.34; H, 7.47; N. 4.94 Found: C, 59.36; H, 7.65; N, 5.10.

EXAMPLE 244 N-2- (4-cyclopropylcarbonylphenyl) propyl 2-propanesulfonamide A solution at 0 ° C of the product from Preparation 67 (0.18 g, 0.63 mmol) in acetone was treated with 4-methylmorpholine (0.095 g, 0.94 mmol) and isobutyl chloroformate (0.094 g, 0.69 mmol). The reaction mixture was stirred for 30 minutes and concentrated in vacuo. The resulting white solid was taken up in DMF and cyclopropylamine (0.040 g, 0.69 mmol), and DMAP (catalytic) was added. The reaction mixture was stirred for 16 hours at room temperature. Water (15 ml) was added and the organic extracted with methylene chloride (2X20 ml). The combined organic layers were washed with a saturated aqueous solution of NaHS04 (20 ml), brine (20 ml), dried over magnesium sulfate and concentrated in vacuo. The crude material was purified by flash chromatography (Si02, 30% EtOAc: hexanes) to give 0.09 g (56%) of a white solid as a pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 324.2 Analysis for Ci6H24N203S: Theory: C, 59.23; H, 7.46; N, 8.63 Found: C, 59.35; H, 7.69; N, 8.53 EXAMPLE 245 N-2- (4-cyclopentylcarbanoylphenyl) propyl 2-propanesulfonamide The title compound 90 mg (41%) was prepared as a solid following the method of Example 244, starting from the material of Preparation 67 and using cyclopentylamine. The NMR was consistent with the structure of the proposed title. Spectrum Desorption Field Mass: M + = 352.2 Analysis for C? 8H28N2? 3S: Theory: C, 61.33; H, 8.01; N, 7.95 Found: C, 61.08; H, 7.78; N, 8.07 EXAMPLE 246 2-propanesulfonamide of N-2- (4- (2-fluorophenyl) carbanoyl) phenyl) propyl The title compound 105 mg (50%) was prepared as a solid following the method of Example 244, starting from the material of Preparation 67 and using 2-fluoroaniline. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 378 Analysis for Ci8H28 203S: Theory: C, 61.20; H, 6.42; N, 7.145 Found: C, 61.12; H, 6.27; N, 6.87 EXAMPLE 247 N-2- (4-benzylsulfonylaminophenyl) propyl 2-propanesulfonamide The title compound 63 mg (82%) was prepared as a solid following the method of Example 179, starting from the material of Preparation 58 and using benzylsulfonyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 396.

EXAMPLE 248 2-propylsulfonamide of N-2- (4- (2-thienyl) sulfonylamino) phenyl) propyl The title compound was prepared as a solid following the method of Example 187, starting from the product of Preparation 58 and using 2-thienylsulfonyl chloride. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 428.2 EXAMPLE 249 and 250 2-propanesulfonamide of N-2- (4- (3-oxacyclopentyl) phenyl) propyl (A) and 2-propanesulfonamide of N-2- (4- (3-hydroxycyclopentyl) phenyl) propyl (B).

A solution of the material of Preparation 75 (0.15 g, 0.47 mmol) in EtOAc (5 mL) was treated with palladium on carbon (0.02 g, 10% mole) under an atmosphere of hydrogen. The mixture was stirred at room temperature for 4 hours and then heated at 50 ° C for 2 hours. The reaction was filtered through a pad of celite and the filtrate was concentrated in vacuo. The crude mixture of both title products was purified by flash chromatography (Si02, EtOAc: hexanes) to give 0.06 g (40%) of the compound of the first title (A) and 0.05 g (33%) of the second title (B): (A) The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 323. Analysis for C? H25N03S: Theory: C, 63.13; H, 7.91; N, 4.33 Found: C, 63.34; H, 7.76; N, 4.30 (B) The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 325. Analysis for C? 7H27N03S: Theory: C, 62.74; H, 8.36; N, 4.30 Found: Cm 62.54; H, 8.27; N, 4.24.

EXAMPLE 251 2-propanesulfonamide of N-2- (4- (2-hydroxy-2-phenyl) ethylphenyl) propyl A solution of the title compound of Example 242 (65 mg, 0.18 mmol) in ethanol (5 ml) was treated with sodium borohydride (9 mg, 0.22 mmol). The reaction mixture was stirred for 2 hours and water was added slowly (2 ml). The mixture was extracted with methylene chloride (2X10 ml). The combined organic layers were washed with brine 95 ml), dried over magnesium sulfate and concentrated in vacuo. The resulting crude product was diluted with EtOAc and filtered through one more inch of silica gel and concentrated in vacuo to give 61 mg (94%) of a colorless oil as a pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 361.

Analysis for C20H27NO3S: Theory: C, 66.45; - H, 7.53; N, 3.87 Found: C, 66.36; H, 7.77; N, 3.63 EXAMPLE 252 N-2- (4-formylphenyl) propyl 2-propanesulfonamide The title compound 1.18 g (68%) was prepared as a solid following the method of Example 243, starting from the product of Preparation 39 and using dimethylformamide. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 269.3 Analysis for C? 3H? 9N03S: Theory: C, 57.97, H, 7.11; N, 5.20 Found: C, 57.78; H, 6.95; N, 5.00 EXAMPLE 253 2-propanesulfonamide of N-2- (4- (l-pyrrolidinyl) phenyl) propyl A solution of material from Preparation 60 (0.17 g, 0.45 mmol) in DMF (20 ml) was treated with diiodobutane (0.15 g, 0.95 mmol) followed by sodium hydride (38 mg, 0.47 mmol). The reaction mixture was heated at 70 ° C for 4 hours. Water (10 ml) was added and the organic extracted with ether (2X20 ml). The combined organic layers were washed with brine (10 ml), dried over magnesium sulfate and concentrated. The crude product was further purified by flash chromatography (Si02, EtOAc: 20% Hexanes) to give 0.10 g of an oil. This oil was diluted with methylene chloride (10 ml) and TFA was added. The reaction was stirred at room for 3 hours. Water (5 ml) was added and the organic was further washed with brine (5 ml), dried over magnesium sulfate and concentrated in vacuo. Flash chromatography (Si02), 30% EtOAc: hexanes) gave 20 mg (14%) of a white solid as the pure product. The NMR "was consistent with the structure of the proposed title: Mass Spectrum Desorption Field: M + = 310.2 EXAMPLE 254 2-N-2- (4-N- (benzamido) phenyl) -2-methylpropyl 2-propanesulfonamide To a solution of the amine of Preparation 82 (150 mg, 0.56 mmol) and triethylamine (65 mg, 1.1 equivalents) in dichloromethane (20 ml) was added dropwise benzoyl chloride (87 mg, 1.1 equivalents) in dichloromethane (5 ml) at room temperature under nitrogen . After 1 hour, the reaction was complete. The solution was washed once with H20 dried over K2CO3 and concentrated under reduced pressure to provide 206 mg of a solid. The material was recrystallized from hexane / ethyl acetate 5: 1 to provide 141 mg as crystals. P.f. 202.5-204 ° C (67%).

The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 375 7Analysis for C2oH2e 203S: Theory: C, 64. 14; H, 7 00; N, 7 48 Found: C, 64.20; H, 7.25; N, 7.58 EXAMPLE 255 2-propanesulfonamide of N-2- (4-N- (cyclobutylcarboxamido) phenyl) -2-methylpropyl The title compound was prepared as a solid following the method of Example 254, starting from the product of Preparation 82 (100 mg, 0.37 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with cyclobutanecarbonyl chloride (48 mg, 1.1 equivalents). The resulting solid was recrystallized from 4: 1 ethyl acetate / hexanes to provide 74 mg of crystals. P.f. 186-188 ° C (57%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 353 Analysis for C? 8H28N203S: Theory: C, 61.33; H, 8.01; N, 7.95 Found: C 61.51; H, 7.77; N, 7.80 EXAMPLE 256 2-propanesulfonamide of N-2- (4-N- (propanoylamido) phenyl) -2-methylpropyl The title compound was prepared as a solid following the method of Example 254, starting with the product of Preparation 82 (100 mg, 0.37 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with porpanoyl chloride (45 mg, 1.1 equivalents). The resulting solid was recrystallized from 4: 1 ethyl acetate / hexanes to provide 75 mg of crystals. P.f. 154-155 ° C (58%). The NMR was consistent with the structure of the proposed title. Field of Mass Spectrum Desorption: M + = 327 Analysis for Ci6H26N203S: Theory: C, 58.87; H, 8.03; N, 8.58 Found: C 58.96; H, 7.75; N, 8.54 EXAMPLE 257 2-propanesulfonamide of N-2- (4-N- (2-thienylcarboxamido) phenyl) -2-methylpropyl The title compound was prepared as a solid following the method of Example 254, starting from the product of Preparation 82 (100 mg, 0.37 mmol) and treated with 2-thiophene chloride (66 mg, 1.2 equivalents). The resulting solid was recrystallized from 2: 1 ethyl acetate / hexanes to provide 77 mg of crystals. P.f. 183-185 ° C (55%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 381 Analysis for C? 8H24N203S2: Theory: C, 56.81; H, 6.36; N, 7.36 Found: C 56.90; H, 6.57; N, 7.39 EXAMPLE 258 2-propanesulfonamide of N-2- (4-N- (3- (5-ethyl) isoxazolylcarboxamido) phenyl) -2-methylpropyl The title compound was prepared as a solid following the method of Example 254, starting from the product of Preparation 82 (100 mg, 0.37 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with 5-methyl-3-chloride. -isoxazole (68 mg, 1.2 equivalents). The resulting solid was recrystallized from 1: 1 ethyl acetate / hexanes to provide 83 mg of crystals. P.f. 118-120 ° C (59%). The NMR was consistent with the structure of the proposed title. Field of Mass Spectrum Desorption: M + = 380 Analysis for C? 8H25N304S: Theory: C, 56.97; H, 6.64; N, 11.07 Found: C 57.11; H, 6.68; N, 11.16 EXAMPLE 259 2-Propanesulfonamide of N-2- (4-N- (phenoxymethylcarboxamido) phenyl) -2-methylpropyl The title compound was prepared as a solid following the method of Example 254, starting from the product of Preparation 82 (100 mg, 0.37 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with phenoxyacetyl chloride (76 mg, 1.2 equivalents). The resulting solid was recrystallized from 1: 1 ethyl acetate / hexanes to provide 80 mg of crystals. P.f. 143-144 ° C (54%). The NMR was consistent with the structure of the proposed title. Field of Mass Spectrum Desorption: M + = 405 Analysis for C2? H28N204S: Theory: C, 62.35; H, 6.98; N, 6.93 Found: C 62.37; H, 6.83; N, 6.74 EXAMPLE 260 2-propanesulfonamide of N-2- (4-N- (4-ethylbenzamido) phenyl) -2-methylpropyl The title compound was prepared as a solid following the method of Example 254, starting from the product of Preparation 82 (100 mg, 0.37 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with 4-ethylbenzoyl chloride (76 mg , 1.2 equivalents). The resulting solid was recrystallized from 1: 1 ethyl acetate / hexanes to provide 68 mg of crystals.

P.f. 118-119 ° C (49%). The NMR was consistent with the structure of the proposed title. Field of Desorption Mass Spectrum: M + = 403 Analysis for C22H30N2O3S: Theory: C, 65.64; H, 7.51; N, 6.96 Found: C 65.84; H, 7.47; N, 7.06 EXAMPLE 261 2-propanesulfonamide of N-2- [4-N- (cyclohexylcarboxamido) phenyl] -2-methylpropyl The title compound was prepared as a solid following the method of Example 254, starting with the product of Preparation 82 (100 mg, 0.37 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with cyclohexanecarbonyl chloride (51 mg, 1.2 equivalents). The resulting solid was recrystallized from 3: 1 ethyl acetate / hexanes to provide 91 mg of crystals. P.f. 203-205 ° C (65%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 381 Analysis for C20H32N2O3S: Theory: C, 63.13; H, 8.48; N, 7.36 Found: C 63.41; H, 8.66; N, 7.58 EXAMPLE 262 N-2- [4-N- (isonicotinylamido) phenyl] -2-methylpropyl 2-propanesulfonamide The title compound was prepared as a solid following the method of Example 254, starting from the product of Preparation 82 (100 mg, 0.37 mmol) and triethylamine (90 mg, 2.2 equivalents) was treated with isonicotinoyl chloride HCl (100 mg, 1.2 equivalents). The resulting solid was recrystallized from 1: 1 ethyl acetate / hexanes to provide 90 mg of crystals. P.f. 174-175 ° C (65%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 376 Analysis for Ci9H25N303S: Theory: C, 60.78; H, 6.71; N, 11.19 Found: C 61.01; H, 7.01; N, 11.04 EXAMPLE 263 2-dimethylsulfamide N-2- (4-N- (benzamido) phenyl) propyl To a solution of the amine of Preparation 84 (100 mg, 0.39 mmol) and triethylamine (45 mg, 0.43 mmol) in dichloromethane (20 ml) was added dropwise, benzoyl chloride (61 mg, 1.2 equivalents) in dichloromethane (5 ml) at room temperature under nitrogen . After 1 hour, the reaction was complete. The solution was washed once with H20, dried over K2CO3 and concentrated under reduced pressure to provide 139 mg of a solid. The material was recrystallized from hexane / ethyl acetate 3: 1 to provide 70 mg as crystals, m.p. 146-148 ° C (58%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 362 Analysis for C28H23N303S: Theory: C, 59.81; H, 6.41; N, 11.63 Found: C, 60.80; H, 6.36; N, 11.45 EXAMPLE 264 N, N-dimethylsulfonamide of N-2- (4-N- (cyclobutylcarboxamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 263, starting from the product of Preparation 84 (100 mg, 0.39 mmol ) and triethylamine (45 mg, 1.2 equivalents) was treated with cyclobutanecarbonyl chloride (55 mg, 1.2 equivalents). The resulting solid was recrystallized from 3: 1 ethyl acetate / hexanes to provide 55 mg of crystals. P.f. 161-162 ° C (42%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 340 Analysis for Ci6H25N303S: Theory: C, 56.61; H, 7.42; N, 12.38 Found: C 56.91; H, 7.66; N, 12.45 EXAMPLE 265 N, N-N-dimethylsulfamide of N-2- (4-N- (propionylamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 263, starting with the product of Preparation 84 (100 mg, 0.39 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with propionyl chloride (40 mg, 1.2 equivalents). The resulting solid was recrystallized from 4: 1 ethyl acetate / hexanes to provide 57 mg of crystals. P.f. 109-110.5 ° C (51%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 314 Analysis for C? H23N303S: Theory: C, 53.65; H, 7.40; N, 13.41 Found: C 53.91; H, 7.48; N, 13.41 EXAMPLE 266 N, N-dimethylsulfamide of N-2- (4-N- (2-thienylcarboxamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 263, starting from the product of Preparation 84 (100 mg, 0.39 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with 2-thiophene chloride (70 mg , 1.2 equivalents). The resulting solid was recrystallized from 1: 1 ethyl acetate / hexanes to provide 62 mg of crystals. P.f. 148-150 ° C (43%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 353 Analysis for Ci6H2iN3? 3S2: Theory: C, 52.30; H, 5.76; N, 11.43 Found: C 52.59; H, 5.78; N, 11.23 EXAMPLE 267 N, N-N-dimethylsulfamide of N-2- (4-N- (3- (5-methyl) osoxazolylcarboxamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 263, starting from the product of Preparation 84 (100 mg, 0.39 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with 3-isoxazole acid chloride (70 mg). mg, 1.2 equivalents). The resulting solid was recrystallized from 4: 1 ethyl acetate / hexanes to provide 78 mg of crystals. P.f. 135-140 ° C (55%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 367 Analysis for C? EH22N404S: Theory: C, 52.44; H, 6.05; N, 15.29 Found: C 52.71; H, 6.20; N, 15.28 EXAMPLE 268 N, N-N-dimethylsulfamide of N-2- (4-N- (phenoxymethylcarbpxamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 263, starting from the product of Preparation 84 (100 mg, 0.39 mmol ) and triethylamine (45 mg, 1.2 equivalents) was treated with phenoxyacetyl chloride (73 mg, 1.2 equivalents). The resulting solid was recrystallized from 9: 1 ethyl acetate / hexanes to provide 73 mg of crystals. P.f. 120-121 ° C (48%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 392 Ajiálisis for Ci9H25N304S: Theory: C, 58.29; H, 6.44; N, 10.73 Found: C 58.49; H, 6.22; N, 10.45 EXAMPLE 269 N, N-dimethylsulfamide of N-2- (4-N- (4-ethylbenzamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 263, starting from the product of Preparation 84 (100 mg, 0.39 mmol) and triethylamine (45 mg, 1.2 equivalents) was treated with 4-ethylbenzoyl chloride (80 mg , 1.2 equivalents). The resulting solid was recrystallized from hexanes / ethyl acetate 2: 1 to provide 87 mg of crystals. P.f. 131-133 ° C (57%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 390 Analysis for C2oH27N3? 3S: Theory: C, 61.67; H, 6.99; N, 10.79 Found: C 61.49; H, 6.79; N, 10.97 EXAMPLE 270 N, N-N-dimethylsulfamide of N-2- (4-N- (isonicotinylamido) phenyl) propyl The title compound was prepared as a solid following the method of Example 263, starting from the product of Preparation 84 (100 mg, 0.29 mmol) and triethylamine (75 mg, 2.2 equivalents) was treated with isonicotinoyl chloride HCl (78 mg, 1.2 equivalents). The resulting solid was recrystallized from hexanes / ethyl acetate 2: 1 to provide 70 mg of crystals. P.f. 156-15 ° C (50%). The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 363 Analysis for C? 7H22N? 3S: Theory: C, 56.34; H, 6.12; N, 15.46 Found: C 56.62; H, 5.80; N, 15.17 EXAMPLE 271 N-2- (2-thien-3-yl-5-thienyl) propyl 2-pro-sulphonamide A. (2-acetyl-5-thien-3-yl) thiophene A solution of 1.45 g (7.10 mmol) of 2-acetyl-5-bromothiophene2.0 g (7.81 mmol) of thiophene 3-boronic acid, 328 mg 80.28 mmol) of tetrakis (triphenylphosphamine) palladium and 1.47 g (10.6 mmol) of potassium carbonate in 32 ml of dioxane and 8 ml of water were heated at 90 ° C for 3 days. Brine was added and extracted three times with ethyl acetate. The organic phase was dried over Na 2 SO 4, filtered and concentrated in vacuo. Chromatography (300 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 1-10 g (74%) of the title compound.

B.2- [2- (thien-3-yl) -5-thienyl] propylamine To a solution at -15 ° C of 1.1 g (5.3 mmol) of the material prepared in Step A and 1.05 g (5.35 mmol) of Tosylmethyl isocyanide in 18 ml of DME, a warm solution of 1.07 g (9.54 mmol) of potassium tert-butoxide in 5 ml of tert-butanol was added slowly. The mixture was stirred at -5 ° C for 45 minutes and 2 hours at room temperature. The water was added and extracted three times with diethyl ether. The organic phase was dried over Na 2 SO 4, filtered and concentrated in vacuo. The crude material was dissolved in 15 ml of diethyl ether and then added to a suspension of 218 mg (5.75) of lithium aluminum hydride in 5 ml of diethyl ether. The mixture was stirred at room temperature for 2 hours, Na2SO410 * H2O was added, and the mixture was stirred for 30 minutes at room temperature. The solid was filtered and the organic solution was concentrated in vacuo. Chromatography (150 g of silica gel, ethyl acetate / hexane / methanol 10/10/1) of the residue afforded 250 mg (22%) of the title compound.

C. To a 0 ° C solution of 200 mg (0.89 mmol) of the material prepared in step B in dichloromethane (5 ml), triethylamine in 0.15 ml (1.07 mmol) was added, followed by isopropylsuifonyl chloride (0.12 p. 1.07 mmol). The cold bath was removed and the solution was stirred at room temperature overnight. The organic solution was washed with 1 N hydrochloric acid, with a saturated sodium bicarbonate solution, brine, dried over Na 2 SO, filtered and concentrated in vacuo. Chromatography (100 g of silica gel, 25% ethyl acetate / hexane) of the residue afforded 61 mg (21%) of the title compound. Analysis calculated for C14H? 9N0S3:% C, 51.03; % H, 5.81; % N, 4.25. Found:% C, 51.30; % H, 5.81; % N, 4.25. Mass Spectrum Desorption Field: M + = 329.

EXAMPLE 272 N-2- (2-thien-3-yl-4-thienyl) propyl 2-propanesulfonamide Prepared as in Example 271 using 4.38 g (21.31 mmol) of 4-acetyl-2-bromothiodene and 3 g (23.44 mmol) of thiophene boronic acid. After three steps, 421 mg (6%) total yield was provided. Field of Mass Spectrum Desorption: M = 329 EXAMPLE 273 N-2- (2-thien-3-yl-5-pyridyl) propyl 2-propanesulfonamide A.2- (2-thien-3-yl-5-pyridyl) propanenitrile A solution of 960 mg (4.8 mmol) of 5-acetyl-2-bromopyridine, 676 mg (5.28 mmol) of 3-boronic acid of thiophene, 222 mg (0.19 mmol) of tetrakis (triphenylphosphamine) palladium and 995 mg (7.2 mmol) of potassium carbonate in 13 ml of dioxane and 3 ml of water were heated at 90 ° C overnight. Brine was added and extracted three times with ethyl acetate. The organic phase was dried over Na 2 SO 4, filtered and concentrated in vacuo. To a solution of the crude and 475 mg (14.4 mmol) of lithium cyanide in 16 ml of THF, 2.2 ml (14.4 mmol) of diethyl cyanophosphonate was added neat at room temperature.The mixture was stirred at room temperature for 30 minutes. The water was added and extracted with a 1: 1 solution of ethyl acetate / hexane.The organic solution was dried over Na 2 SO, filtered and concentrated in vacuo.The crude was dissolved in 10 ml of THF and added in the form of drop to a solution of samarium iodide was prepared from 3.32 g (22.08 ramol) of samarium and 3.89 g (13.8 mmol) of 1,2-diodoethane.The mixture was stirred for 1 hour.A 2.5 N acid solution was added. The organic phase was washed with a 1 N solution of sodium thiosulfate and the organic solution was dried over anhydrous hydrochloric acid and extracted three times with diethyl ether.

Na2SO was filtered and concentrated in vacuo. Chromatography (100 g of silica gel, 25% ethyl acetate / hexane) of the residue gave 225 mg (22%) of the title compound.

B. To a room temperature solution of 214 mg (1 mmol) of the material prepared in Step A in 5 ml of THF, 0.11 mmol of a 10 M solution of the borane-methyl sulfide complex was added as a drop ( 1.1 mmol) in THF. The mixture was stirred at room temperature for 2 hours. Then, 0.1 ml of a solution of borane-methyl sulfide complex (1.0 mmol) in THF was added and the mixture was stirred overnight. A saturated solution of hydrochloric acid in methanol (5 ml) was added, and stirred for 10 minutes. The solution was concentrated in vacuo. The crude was dissolved in dichloromethane (5 ml) and cooled to 0 ° C, triethylamine 0.44 ml (3.2 mmol) was added, followed by isopropylsulfonyl chloride (0.14 ml, 1.2 mmol). The cold bath was stirred and the solution was stirred at room temperature for 2 hours. The organic solution was washed with 1 N hydrochloric acid, a saturated sodium bicarbonate solution, brine, dried over Na 2 SO, filtered and concentrated in vacuo. Chromatography (50 g of silica gel, 33% ethyl acetate / hexane) of the residue afforded 25 mg (7%) of the title compound. Mass Spectrum Desorption Field: M + = 324.

EXAMPLE 274 2-propanesulfonamide of (+) - N-2R- (4- (3-thienyl) phenyl) propyl To a solution of 0.75 g (3.5 mmol) of the material of Preparation 102 and 0.60 mL (3.8 mmol) of 1,8-diaza-bicyclo [5.4.0] undec-7-ene in 10 mL of dichloromethane at 0 ° C 0.40 mL (3.5 mmol) of 2-propanesulfonyl chloride was added. The mixture was stirred at room temperature for 4 hours and then washed with 10 mL of 1N hydrochloric acid, the organic layer was separated and the aqueous layer was extracted once with 5 mL of dichloromethane. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Recrystallization from methyl alcohol gave 0.46 g (41%) of the title compound. Analysis calculated for Ci6H2? N02S2:% C, 59.41; % H, 6.54; % N, 4.33. Found:% C, 59.69; % H, 6.68; % N, 4.42. Mass Spectrum Desorption Field: M + l = 324 [a] D20 = +42.55 (c = 0.99, CHC13) EXAMPLE 275 2-propanesulfonamide of (+) - N-2S- (4- (3-thienyl) phenyl) propyl Following the procedure of Example 274 and using material from Preparation 103 in place of the material from Preparation 102, 0.45 g (39%) of the title compound was provided. Analysis calculated for C? 6H? N02S2:% C, 59.41; % H, 6.54; % N, 4.33. Found:% C, 59.71; % H, 6.35; %, 4.43. Mass Spectrum Desorption Field: M + l = 324 [a] D20 = -43.98 (c = 1.05, CHC13) EXAMPLE 276 N ', N'-dimethylsulfamide of (+) - N-2R- (4- (3-thienyl) phenyl) propyl To a solution of 1.0 g (0.46 mmol) of the material of Preparation 102 and 0.07 mL (0.46 mmol) of 1,8-diazabicyclo [5.4.0] undec-7-ene in 10 mL of dichloromethane at 0 ° C. 0.05 mL (0.46 mmol) of N, N-dimethylsulfamoyl chloride was added. The mixture was stirred at room temperature for 4 hours and then washed with 10 mL of 1N hydrochloric acid, the organic layer was separated and the aqueous layer was extracted once with 5 mL of dichloromethane. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (10 g of silica gel, 25% ethyl acetate / hexane) of the residue gave 0.04 g (26%) of the title compound. 'Analysis calculated for C? 5H20N202S2:% C, 55.53; % H, 6.21; % N, 8.63. Found:% C, 55.39; % H, 6.08; % N, 8.50 Mass Spectrum Desorption Field: M + l = 325 [a] D20 = +20.75 (c = 0.77, CHC13).

EXAMPLE 277 N ', N'-dimethylsulfamide of (-) - N-2S- (4- (3-thienyl) phenyl) propyl Following the procedure of Example 276 and using the material of Preparation 103 in place of the material of Preparation 102 and providing 0.02 g (13%) of the title compound. Analysis calculated for C? S 2o 202S2:% C, 55.53; % H, 6.21; % N, 8.63. Found:% C, 55.31; % H, 6.23; % N, 8.36. Mass Spectrum Desorption Field: M + l = 325 [a] D20 = -25.81 (c = 1.24, CHC13).

EXAMPLE 278 2-propanesulfonamide of (+) - N-2R- (4- (2-pyridyl) phenyl) propyl A. (R) -2- (4- (2-pyridyl) phenyl) -N- (t-butoxycarbonyl) propylamine: To a solution of 1.0 g (3.2 mmol) of the material of Preparation 92 and 1.2 g (3.2 mmol) ) of 2- (tri-n-butylstannyl) pyridine in 10 mL of dioxane, 0.18 g (0.16 mmol) of tetrakis (triphenylphosphamine) palladium was added. The mixture was heated at 100 ° C for 18 hours. The mixture was cooled and concentrated in vacuo. Chromatography (150 g of silica gel, 25% ethyl acetate / hexane) of the residue gave 0.87 g (85%) of the title compound.

B. To a solution of 0.85 g (2.7 mmol) of the material of Example 278A in 5 mL of ethyl acetate, was added 5 mL of ethyl acetate saturated with hydrochloric acid. The mixture was stirred at room temperature for 3 hours and then concentrated in vacuo. The residue was suspended in 5 mL of methyl alcohol and a vacuum was concentrated and then dissolved in 5 mL of dichloromethane. To the mixture was added 1.2 mL (8.4 mmol) of 1,8-diazabicyclo [5.4.0] undec-7-ene and the solution was cooled to 0 ° C. To this mixture was added 0.30 mL (2.7 mmoL) of 2-propanesulfonyl chloride. The mixture was stirred at room temperature for 4 hours and then washed with 5 mL of 1N hydrochloric acid, the organic layer was separated and the aqueous layer was extracted three times with 5 mL of dichloromethane. The combined organics were dried (MgSO 4), filtered and concentrated in vacuo. Chromatography (25 g of silica gel, 50% ethyl acetate / hexane) of the residue afforded 0.49 g (57%) of the title compound. Analysis calculated for C? 7H22N202S:% C, 64.12; % H, 6.96; % N, 8.80. Found:% C, 64.22; % H, 6.71; % N, 8.82. Mass Spectrum: M + l = 319. [a]? A = +40 (c = 1 .0, CHC13) EXAMPLE 279 2-propanesulfonamide of (-) - N-2S- (4- (2-pyridyl) phenyl) propyl Following the procedure of Example 278 and using the material of Preparation 99 instead of the material of Preparation 22, 0.36 g (47%) of the title compound was provided. Analysis calculated for C? 7H22 2? 2S:% C, 64.12; % H, 6.96; % N, 8.80. Found:% C, 63.93; % H, 6.86; % N, 8.65. Mass Spectrum: M + l = 319. [a] D20 = 36 (c = 1.0, CHC13) EXAMPLE 280 N-2- (4-N-phenyloxalylamido) phenyl) propyl 2-propanesulfonamide A solution at -78 ° C of the material of Example 222 (0.28 g, 0.79 mmol) in THF (5 ml) was treated with phenylmagnesium bromide ( 0.27 ml, 0.82 mmol). The reaction mixture was heated slightly to dissolve the solid. After an additional 1 hour, phenylmagnesium bromide (0.27 ml, 0.82 mmol) was added at -78 ° C and the mixture was stirred for 2 hours. The reaction mixture was rapidly cooled to -78 ° C with a 10% solution of ammonium chloride. The organic was extracted with ether (2x20 ml). The combined organic layers were washed with brine (10 mL), dried over magnesium sulfate, and concentrated. The crude product was further purified by flash chromatography (Si02, EtOAc: 30% Hexanes) to give 0.31 g (46%) of a yellow oil as the pure product. The NMR was consistent with the structure of the proposed title. Mass Spectrum Desorption Field: M + = 389.3.

It is noted that, in relation to this date, the best method known by the applicant to carry out the aforementioned invention is that which is clear from the present description of the invention.

Having described the invention as above, the content of the following is claimed as property.

Claims

1. Use of a compound of formula R1-L-NHS02R2 I in which R1 represents a substituted or unsubstituted aromatic or heteroaromatic group; R2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (from 3 to 6 carbon atoms), fluoroalkyl (from 1 to 6 carbon atoms), chloroalkyl (from 1 to 6 carbon atoms), alkenyl (from 2 to 6 carbon atoms), akoxy (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), phenyl which is substituted or unsubstituted by halogen, alkyl (of 1 to 4 carbon atoms) or alkoxy (of 1 to 4 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms) ) or, together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl, morinobin, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents an alkylene chain of (2 to 4 carbon atoms) which is substituted or unsubstituted by one or two substituents independently selected from alkyl (1 to 6 carbon atoms), aryl (1 to 6 atoms) carbon) alkyl, alkenyl (of 2 to 6 carbon atoms), aryl (of 2 to 6 carbon atoms) alkenyl and aryl, or by two substituents which together with the carbon atom or carbon atoms to which they are united, they form a carbocyclic ring of (3 to 8 carbon atoms); or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for enhancing the function of the glutamate receptor.

2. The use as claimed in Claim 1, wherein R2 represents alkyl (from 1 to 6 carbon atoms, fluoroalkyl (from 1 to 6 carbon atoms), • alkenium (of 2 to 6 carbon atoms), or a group of formula R3R4N in which, R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms) or, together with the nitrogen atom to which they are attached; united, they form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or oactahydroazocinyl group.

3. Use as claimed in Claim 1 or 2, wherein L represents a group of the formula R8 p6 1 f -C- c- R5 R7. wherein two of R5, R6 R7 and R8 represent hydrogen and the residue independently represents hydrogen, alkyl (of 1 to 6 carbon atoms), aryl (of 1 to 6 carbon atoms) alkyl, alkenyl (of 2 to 6 atoms) carbon), aryl (2 to 6 carbon atoms) aikenium or aryl, or together with the carbon atom or carbon atoms to which they are attached form a carbocyclic ring (of 3 to 8 carbon atoms).

4. The use as claimed in Claim 3, wherein R6 and R7 represent hydrogen, and R5 and R8 each independently represent hydrogen or alkyl (of 1 to 4 carbon atoms), or together with the carbon atom to which they are attached. together they form a carbobicyclic ring (of 3 to 8 carbon atoms).

5. The use as claimed in claim 4, wherein R8 represents alkyl having 1 to 4 carbon atoms) or R5 and R8 together with the carbon atom to which they are attached form a cyclopropyl ring.

6. Use as claimed in any one of claims 1 to 5, wherein R2 represents methyl, ethyl, propyl, 2-propyl, butyl, 2-methylpropyl, cyclohexyl, trifluoromethyl, 2,2,2-trifluoroethyl, chloromethyl, ethenyl, prop-2-enyl, methoxyethyl, phenyl, 4-fluorophenyl or dimethylamino.

7. Use as claimed in Claim 6, in which R2 represents ethyl, 2-propyl or dimethylamino.

8. Use as claimed in any one of claims 1 to 7, wherein R1 preferably represents a naphthyl or phenyl, furyl, thienyl or pyridyl group which is substituted or unsubstituted by one or two substituents independently selected from halogen, nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); hydroxy (from 3 to 8 carbon atoms) cycloalkyl; oxo (3 to 8 carbon atoms) cycloalkyl; halo (from 1 to 10 carbon atoms) alkyl; where y is 0 or an integer from 1 to 4, X1 represents O, S, NR10, CO, COO, OCO, CONR11, NR12CO, NR12COCOO, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms) , alkenyl (from 3 to 10 carbon atoms, alkynyl (from 3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, morpholino or cycloalkyl (from 3 to 8 carbon atoms) and R10, R11, R2 and R13 each independently represent hydrogen or alkyl (from 1 to 10 carbon atoms), or R9 and R10, R11, R12 or R13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; N- (from 1 to 4 carbon atoms) alkylpiperazinyl, N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl, thienyl, furyl, oxazolyl, isoxazolyl, pyrazolyl, imidazolyl, thiazolyl, pyridyl, pyridazinyl, pyrimidinyl, dihydrothienyl, dihydrofuryl, dihydrothiopyranyl, dihydropyranyl, dihydrothiazolyl. , alkoxycarbonyldihydrothiazolyl (1 to 4 carbon atoms); rbonyldimethyldihydrothiazolyl (1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R 14 - (La) n-X 2 - (Lb) m in which X 2 represents a bond, 0, NH, S, SO, S02, CO, CH (OH), CONH, NHCONH, NHCO, NHCOO , COCONH, OCH2CONH or CH = CH, La and L each represent alkylene (of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, and R14 represents a phenyl or heteroaromatic group which is substituted or unsubstituted by one or two of halogen, nitro, cyano, hydroxyimino, alkyl (of 1 to 10 carbon atoms), alkenyl (of 2 to 10 carbon atoms), alkynyl (of 2 to 10 carbon atoms), cycloalkium (from 3 to 8 carbon atoms), 4- (1,1-dioxotetrahydro-l, 2-thiazinyl), halo (from 1 to 10 carbon atoms) alkyl, cyano (from 2 to 10 carbon atoms) alkenyl , phenyl, and (CH2) zX3R15 in which z is 0 or an integer of about 1 to 4, X3 represents O, S, NR16, CO, CH (OH), COO, OCO, CONR17, NR18CO, NHS02, NHS02NR17, NHCONH, OCONR19 or NR19COO, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 carbon atoms) alkyl, haloalkyl (from 1 to 10 carbon atoms), alkoxycarbonyl (from 1 to 4 carbon atoms) alkyl (from 1 to 4 atoms) carbon), alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), (N- (from 1 to 4 carbon atoms) alkoxycarbonyl) alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms, alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphor or an aromatic or heteroaromatic group which is substituted or unsubstituted by one or two of halogen, alkyl (of 1 to 4 carbon atoms), halo (of 1 to 4 carbon atoms) alkyl, di (of 1 to 4 carbon atoms) alkylamino and alkoxy ( from 1 to 4 carbon atoms) and R16, R17, R18 and R19 each independently represents hydrogen or alkyl (of 1 to 10 carbon atoms) or R15 and R16, R17, R18 or R19 together with The nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group.

9. Use as claimed in any one of claims 1 to 8, wherein R 1 represents a naphthyl group or a phenyl group which is substituted or unsubstituted by one or two substituents independently selected from halogen, nitro; cyano; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); halo (from 1 to 10 carbon atoms) alkyl; (CH2) and X1R9 in which y is 0 or an integer from 1 to 4, X1 represents O, S, NR10, CO, COO, OCO, CONR11, NR12CO, NR12COCO, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms) , or cycloalkyl (of 3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently represents hydrogen or alkyl (of 1 to 10 carbon atoms), or R9 and R10, R11, R12 or R13 together with the Nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; thienyl; Furyl oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R14- (La) n-X2- (Lb) m in which X2 represents a bond, 0, NH, S, SO, S02, CO, CONH, or NHCO, L and Lb each represent alkylene (of 1 to 4 carbon atoms), one of n and m is O or 1 and the other is 0, and R 14 represents a phenyl or heteroaromatic group which is substituted or unsubstituted by one or two of halogen, nitro, cyano, alkyl (from 1 to 10 carbon atoms), alkenyl (from 2 to 10 carbon atoms), alkynyl (from 2 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), halo (from 1 to 10 atoms) carbon) alkyl, and (CH2) zX3R15 in which z is 0 or an integer from about 1 to 4, X3 represents O, S, NR16, CO, COO, OCO, CONR17, NR18C0, OCONR19, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms) or cycloalkyl (from 3 to 8 carbon atoms), and R, R, R and R each independently represents hydrogen or alkyl (from 1 to 10 carbon atoms) or R15 and R16, R17, R18 or R19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group.

10. Use as claimed in claim 8, wherein R 1 represents 2-naphthyl or a group of formula wherein R20 represents halogen; nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms; hydroxy (alkyl from 3 to 8 carbon atoms) cycloalkyl; oxo (from 3 to 8 carbon atoms) cycloalkyl; halo (from 1 to 10 carbon atoms); (CH2) and X1R9 wherein y is 0 or an integer from 1 to 4, XI represents O, S, NR10, CO, COO, OCO, CONR11, NR12CO, NR12COCOO, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms) , alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, morpholino or cycloalkyl (from 3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently they represent hydrogen or alkyl (from 1 to 10 carbon atoms), or R9, R10, R11, R12 or R13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; 1 to 4 carbon atoms) alkylpiperazinyl; N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; zolyl; tetrazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; alkoxycarbonyldihydrothiazolyl (from 1 to 4 carbon atoms); alkoxycarbonyldimethyldihydrothiazolyl (from 1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R 14 - (La) n-X 2 - (Lb) m in which X 2 represents a bond O, NH, S, SO, S02, CO, CH (OH), CONH, NHCONH, NHCOO, COCONH, 0CH2C0NH or CH = CH, NHCO, La and Lb each represents alkylene (of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, R14 represents a phenyl or heteroaromatic group which is substituted or not replaced by one or two of halogen; nitro; cyano; hydroxyimino, alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); 4- (1,1-dioxotetrahydro-1,2-thiazinyl); halo (from 1 to 10 carbon atoms) alkyl; cyano (from 2 to 10 carbon atoms) alkenyl; phenyl; (CH2) zX3R15 in which z is 0 or an integer from 1 to 4, X3 represents O, S, NR15, CO, CH (OH), COO, OCO, CONR17, NR18CO, NHS02, NHS02R17, NHCONH, OCONR19 or NR19COO , R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 carbon atoms) alkyl, haloalkyl (from 1 to 10 carbon atoms), alkoxycarbonyl (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), (N- (from 1 to 4 carbon atoms) alkoxycarbonyl) lkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphor or an aromatic or heteroaromatic group in which it is substituted or unsubstituted by one or two of halogen, alkyl (of 1 to 4 carbon atoms), and alkoxy (of 1 to 4 carbon atoms), and R16, R17, R18 and R19 each one independent ntely represents hydrogen or alkyl (of 1 to 10 carbon atoms), or R15, R16, R17, R18 or R19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group and R21 represents an atom of hydrogen, a halogen atom, an alkyl group (of 1 to 4 carbon atoms) or an alkoxy group (of 1 to 4 carbon atoms).

11. Use as claimed in the Claim 9, in which R1 represents 2-naphthyl or a group of the formula wherein R20 represents halogen; nitro; cyano; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); halo (from 1 to 10 carbon atoms) alkyl; (CH2) and xA9 in which y is 0 or an integer from 1 to 4, XI represents O, S, NR10, CO, COO, OCO, CONR11, NR12CO, NR12CO, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), or cycloalkyl (from 3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently represent hydrogen or alkyl (from 1 to 10 carbon atoms), or R9, R10, R11, R12 or R13 together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; thienyl; Furyl oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; tetrazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R14- (La) n-X2- (L) m in which X2 represents a bond 0, NH, S, SO, S02, CO, CONH, or NHCO, La and Lb each represents alkylene ( of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, R 14 represents a phenyl group which is substituted or unsubstituted by one or two of halogen; nitro; cyano alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); haloalkyl (from 1 to 4 carbon atoms), (CH2) zX3R15 in which z is 0 or an integer from 1 to 4, X3 represents 0, S, NR16, CO, COO, OCO, CONR17, NR18CO, OCONR19, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms) or cycloalkyl (from 3 to 8 carbon atoms), and R16, R17, R18 or R19, each independently represents hydrogen or, alkyl (of 1 to 10 carbon atoms), or R15 and R16, R17, R18 or R19 together with the nitrogen atom to which they are attached, form an azetidinyl group, pyrrolidinyl, piperidinyl or morpholino; and R21 represents a hydrogen atom, a halogen atom, an alkyl group (of 1 to 4 carbon atoms) or an alkoxy group (of 1 to 4 carbon atoms).

12. Use as claimed in Claim 11, in which R1 represents 2-naphthyl, 4-bromophenyl, 4-benzamidophenyl, 4-methylphenyl, 4-isopropylphenyl, 4-isobutylphenyl, 4-t-butylphenyl, 4-methoxyphenyl, -isopropoxyphenyl, 4-cyclopentylphenyl, 4-cyclohexylphenyl, 4- (2-hydroxymethylphenyl) phenyl, 4- (4-hydroxymethylphenyl) -phenyl, 4- (2-furyl) phenyl, 4- (3-furyl) phenyl, 4- (2-thienyl) -phenyl, 4- (3-thienyl) phenyl, 4- (pyrrolidin-1-yl) phenyl, 4- (piperidin-1-yl) phenyl, 3-chloro-4-piperidin-1-ylphenyl , 4-benzoyloxyphenyl, 4- (2-fluorophenyl) phenyl, 4- (3-fluoro-phenyl) phenyl, 4- (2-formylphenyl) phenyl, 4- (3-formylphenyl) -phenyl, 4- (4-formylphenyl) ) phenyl, 4- (4-methylphenyl) phenyl or 4- (2-methoxyphenyl) phenyl.

13. Use of a compound of the formula R ^ L-NHSO? R2 I in which, R1 represents a substituted or unsubstituted aromatic or heteroaromatic group; R 2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (from 3 to 6 carbon atoms), fluoroalkyl (from 1 to 6 carbon atoms), chloroalkyl (from 1 to 6 carbon atoms), alkenyl (from 2 to 6 carbon atoms), to 6 carbon atoms), alkoxy (of 1 to 4 carbon atoms) alkyl (of 1 to 4 carbon atoms), phenyl which is substituted or unsubstituted by halogen, alkyl (of 1 to 4 carbon atoms) or alkoxy (of 1 to 4 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms) or, together with the nitrogen atom to which they are attached , form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents an alkylene chain of (2 to 4 carbon atoms) which is substituted or unsubstituted by one or two substituents independently selected from alkyl (1 to 6 carbon atoms), aryl (1 to 6 atoms) carbon) alkyl, alkenyl (of 2 to 6 carbon atoms), aryl (of 2 to 6 carbon atoms) alkenyl and aryl, or by two substituents which together with the carbon atom or carbon atoms to which they are united, they form a carbocyclic ring of (3 to 8 carbon atoms); or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of cognitive alterations, neurodegereative alterations; dementias related to age, loss of memory induced by age; "movement" alterations, states of drug-induced disorders, depression, impaired alterations, alteration of deficient hyperactivity of attention, psychosis, cognitive deficiencies associated with psychosis, or drug-induced psychosis.

14. Use of a compound of the formula R ^ L-NHSO? R2 I in which, R1 represents a substituted or unsubstituted aromatic or heteroaromatic group; R 2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (from 3 to 6 carbon atoms), fluoroalkyl (from 1 to 6 carbon atoms), chloroalkyl (from 1 to 6 carbon atoms), alkenyl (from 2 to 6 carbon atoms), to 6 carbon atoms), alkoxy (of 1 to 4 carbon atoms) alkyl (of 1 to 4 carbon atoms), phenyl which is substituted or unsubstituted by halogen, alkyl (of 1 to 4 carbon atoms) or alkoxy (of 1 to 4 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms) or, together with the nitrogen atom to which they are attached, they form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents an alkylene chain of (2 to 4 carbon atoms) which is substituted or unsubstituted by one or two substituents independently selected from alkyl (1 to 6 carbon atoms), aryl (1 to 6 atoms) carbon) alkyl, alkenyl (of 2 to 6 carbon atoms), aryl (of 2 to 6 carbon atoms) alkenyl and aryl, or by two substituents which together with the carbon atom or carbon atoms to which they are united, they form a carbocyclic ring of (3 to 8 carbon atoms); or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the improvement of memory or learning ability.

15. A compound of formula R8 R6 I I RI-C- ~ NHS02R2 wherein R1 preferably represents a naphthyl or phenyl, furyl, thienyl or pyridyl group which is substituted or unsubstituted by one or two substituents independently selected from halogen, nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); 'hydroxy (from 3 to 8 carbon atoms) cycloalkyl; oxo (3 to 8 carbon atoms) cycloalkyl; halo (from 1 to 10 carbon atoms) alkyl; (CH2) and X -'- R9 in which y is 0 or an integer from 1 to 4, X1 represents 0, S, NR10, CO, COO, OCO, CONR11, NR12C0, NR12C0C00, OCONR13, R9 represents hydrogen, alkyl ( from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms, alkynyl (from 3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, morpholino or cycloalkyl (from 3 to 8 carbon atoms) and R10, R11 , R12 and R13 each independently represent hydrogen or alkyl (of 1 to 10 carbon atoms), or R9 and R10, R11, R12 or R13 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino; N- (1 to 4 carbon atoms) alkylpiperazinyl; N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl, alkoxycarbonyldihydrothiazolyl (1 to 4 carbon atoms); alkoxycarbonyldimethyldihydrothiazolyl (from 1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R14- (La) n-X2- (Lb) m in which X2 represents a bond, O, NH, S, SO, S02, CO, CH (OH), CONH, NHCONH, NHCO, NHCOO , COCONH, OCH2CONH or CH = CH, La and Lb each represent alkylene (of 1 to 4 carbon atoms), one of n and m is O or 1 and the other is 0, and R14 represents a phenyl or heteroaromatic group which is substituted or unsubstituted by one or two of halogen, nitro, cyano, hydroxyimino, alkyl (of 1 to 10 carbon atoms), alkenyl (of 2 to 10 carbon atoms), alkynyl (of 2 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), 4- (1,1-dioxotetrahydro-l, 2-thiazinyl), halo (from 1 to 10 carbon atoms) alkyl, cyano (from 2 to 10 carbon atoms) alkenyl , phenyl, and (CH2) zX3R15 in which z is 0 or an integer of about 1 to 4, X3 represents 0, S, NR15, CO, CH (OH), COO, OCO, CONR17, NR18C0, NHS02, NHS02NR17, NHCONH, OCONR19 or NR19COO, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 carbon atoms) alkyl, haloalkyl (from 1 to 10 carbon atoms), alkoxycarbonyl (from 1 to 4 carbon atoms) alkyl (from 1 to 4 atoms) carbon), alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), (N- (from 1 to 4 carbon atoms) alkoxycarbonyl) alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms, alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphor or an aromatic or heteroaromatic group which is substituted or unsubstituted by one or two of halogen, alkyl (of 1 to 4 carbon atoms), haloalkyl (of 1 to 4 carbon atoms), and alkoxy (of 1 to 4 carbon atoms) and R16, R17 , R18 and R19 each independently represents hydrogen or alkyl (of 1 to 10 carbon atoms) or R15 and R15, R17, R18 or R19 together with the nitrogen atom to which they are attached. nests form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group. R 2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (from 3 to 6 carbon atoms), fluoroalkyl (from 1 to 6 carbon atoms), chloroalkyl (from 1 to 6 carbon atoms), alkenyl (from 2 to 6 carbon atoms), to 6 carbon atoms), alkoxy (of 1 to 4 carbon atoms)) alkyl (of 1 to 4 carbon atoms), phenyl, which is not substituted by halogen, alkyl (of 1 to 4 carbon atoms) or alkoxy (of 1 to 4 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms), or together with the nitrogen atom to which they are attached, form azetidinyl, pyrrolidinyl, piperidinyl, morpholino, or piperazinyl group; and either one of R5, R6, R7 and R8 represent alkyl (of 1 to 6 carbon atoms); aryl (from 1 to 6 carbon atoms) alkyl; alkenyl (2 to 6 carbon atoms); aryl (2 to 6 carbon atoms) alkenyl or aryl or two of R5, R6, R7 and R8 together with the carbon atom or carbon atoms to which they are attached form a carbocyclic ring (from 3 to 8 carbon atoms). carbon); and the rest of R5, Rd, R7 and R8 represent hydrogen; or a pharmaceutically acceptable salt thereof, but excluding N- (2,2-diphenylethyl) ethanesulfonamide and those compounds of formula I in which R7 represents methyl; R5, R6 and R8 represents hydrogen; and (a) R1 represents phenyl, and R2 represents methyl, butyl, fluoromethyl, difluoromethyl, trifluoromethyl, dimethylamino or piperidinyl; or (b) R1 represents 4-chlorophenyl, 4-nitrophenyl or 3-methoxyphenyl; and R2 represents methyl; or (c) R1 represents 4-nitrophenyl and R2 represents trifluoromethyl.

16. A compound as claimed in Claim 15, in which R1 preferably represents a naphthyl or phenyl group, which is unsubstituted or substituted by one or two substituents independently selected from halogen, nitro; cyano; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); halo (from 1 to 10 carbon atoms) alkyl; (CH2) yX1R9 in which y is 0 or an integer of 1 to 4, X1 represents 0, S, NR10, CO, COO, OCO, CONR11, NR12CO, OCONR13, R9 represents hydrogen, alkyl (of 1 to 10 atoms carbon), alkenyl (from 3 to 10 carbon atoms, alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently represent hydrogen or alkyl ( from 1 to 10 carbon atoms), or R9 and R10, R11, R12 or R13 together with the nitrogen atom to which they are attached form a morpholino azetidinyl, pyrrolidinyl, piperidinyl or; thienyl; furyl; oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl, dihydrofuryl; dihydrothiopyranyl; dihydropyranyl, tetrahydrothienyl, tetrahydrofuryl, tetrahydrothiopyranyl, tetrahydropyranyl, indolyl, benzofuryl, benzothienyl; benzimidazolyl; and a group of formula R14- (La) n-X2- (Lb) m in which X2 represents a bond, 0, NH, S, SO, S02, CO, CONH, or NHCO, La and Lb each represent alkylene (from 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, and R14 represents a phenyl group which is substituted or unsubstituted by one or two of halogen, nitro, cyano, alkyl (from 1 to 10 carbon atoms), alkenyl (of 2 to 10 carbon atoms), alkynyl (of 2 to 10 carbon atoms), cycloalkyl (of 3 to 8 carbon atoms), halo (of 1 to 10 carbon atoms) ) alkyl, and (CH2) zX3R15 in which z is 0 or an integer of approximately 1 to 4, X3 represents 0, S, NR16, CO, COO, OCO, CONR17, NR18CO, OCONR19, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), or cycloalkyl (from 3 to 8 carbon atoms) carbon), and R16, R17, R18 and R19 each independently represents hydrogen or alkyl (of 1 to 10 carbon atoms) or R15 and R16, R17, R18 or R19 together with the nitrogen atom to which they are attached, form a azetidinyl, pyrrolidinyl, piperidinyl or morpholino group. R2 represents alkyl (of 1 to 6 carbon atoms), fluoroalkyl (of 1 to 6 carbon atoms), alkenyl (of 2 to 6 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (from 1 to 4 carbon atoms), or together with the nitrone atom to which they are attached, form azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or ochatahydroazocinyl group.

17. A compound as claimed in Claim 15 or Claim 16, wherein R6 and R7 represent hydrogen.

18. A compound as claimed in Claim 17, in which R5 and R8 each independently represents hydrogen or alkyl (of 1 to 4 carbon atoms), or together with the carbon atom to which they are attached form a carbocyclic ring (from 3 to 8 carbon atoms).

19. A compound as claimed in Claim 18, in which R8 represents methyl or ethyl, or R5 and R8 together with the carbon atom to which they are attached, form a cyclopropyl ring.

20. A compound as claimed in any one of claims 15 to 19, wherein R 1 represents 2-naphthyl or a group of the formula wherein R20 represents halogen; nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); hydroxy (alkyl of 3 to 8 carbon atoms) cycloalkyl; oxo (3 to 8 carbon atoms) cycloalkyl; halo (from 1 to 10 carbon atoms); (CH2) and X1R9 in which y is 0 or an integer from 1 to 4, XI represents O, S, NR10, CO, COO, OCO, CONR11, NR12CO, NR12COCOO, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), pyrrolidinyl, tetrahydrofuryl, morpholino or cycloalkyl (from 3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently represent hydrogen or alkyl (of 1 to 10 carbon atoms), or R9, R10, R11, R12 or R13 together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; N- (from 1 to 4 carbon atoms) alkylpiperazinyl; N-phenyl (1 to 4 carbon atoms) alkylpiperazinyl; thienyl; Furyl oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; tetrazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; dihydrothiazolyl; alkoxycarbonyldihydrothiazolyl (from 1 to 4 carbon atoms); alkoxycarbonyldimethyldihydrothiazolyl (from 1 to 4 carbon atoms); tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; and a group of formula R 14 - (La) n-X 2 - (Lb) m in which X 2 represents a bond 0, NH, S, SO, S02, CO, CONH, NHCONH, NHCOO, COCONH, 0CH2C0NH or CH = CH , NHCO, La and Lb each represents alkylene (of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, R14 represents a phenyl or heteroarsmatic group which is substituted or unsubstituted by one or two halogen; nitro; cyano; hydroxyimino; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); 4- (1,1-dioxotetrahydro-l, 2-thiazinyl); hald (from 1 to 10 carbon atoms) alkyl; cyano (from 2 to 10 carbon atoms) alkenyl; phenyl; (CH2) zX3R15 in which z is 0 or an integer from 1 to 4, X3 represents 0, S, NR16, CO, CH (OH), COO, OCO, CONR17, NR18CO, NHS02, NHS02R17, NHCONH, OCONR19 or NR19C00 , R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms), phenyl (from 1 to 4 carbon atoms) alkyl, haloalkyl (from 1 to 10 carbon atoms), alkoxycarbonyl (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), (N- (from 1 to 4 carbon atoms) alkoxycarbonyl) alkylsulfonylamino (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), cycloalkyl (from 3 to 8 carbon atoms), camphor or an aromatic or heteroaromatic group in which it is substituted or unsubstituted by one or two of halogen, alkyl (1 to 4 carbon atoms) alkoxy, and R16, R17, R18 and R19 each independently represents hydrogen or alkyl (from 1 to 10 carbon atoms), or R15, R16, R17, R18 or R19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group and R21 represents a hydrogen atom, a halogen atom, an alkyl group (of 1 to 4 carbon atoms) or an alkoxy group (of 1 to 4 carbon atoms).

21. A compound as claimed in any one of claims 15 to 19, wherein R 1 represents 2-naphthyl or a group of the formula wherein R20 represents halogen; nitro; cyano; alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); halo (from 1 to 10 carbon atoms); (CH2) and X1R9 in which y is 0 or an integer from 1 to 4, XI represents 0, S, NR10, CO, COO, OCO, CONR11, NR12CO, OCONR13, R9 represents hydrogen, alkyl (from 1 to 10 carbon atoms) carbon), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms), or cycloalkyl (from 3 to 8 carbon atoms) and R10, R11, R12 and R13 each independently represent hydrogen or alkyl (from 1 to 10 carbon atoms), or R9, R10, R11, R12 or R13 together with the nitrogen atom to which they are attached, form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; thienyl; Furyl oxazolyl; isoxazolyl; pyrazolyl; imidazolyl; thiazolyl; tetrazolyl; pyridyl; pyridazinyl; pyrimidinyl; dihydrothienyl; dihydrofuryl; dihydrothiopyranyl; dihydropyranyl; tetrahydrothienyl; tetrahydrofuryl; tetrahydrothiopyranyl; tetrahydropyranyl; indolyl; benzofuryl; benzothienyl; benzimidazolyl; benzothiazolyl; and a group of formula R14- (La) n-X2- (Lb) m in which X2 represents an O, NH, S bond, SO, S02, CO, CONH, or NHCO, La and Lb each represent alkylene (of 1 to 4 carbon atoms), one of n and m is 0 or 1 and the other is 0, R14 represents a phenyl or heteroaromatic group which it is substituted or not substituted by one or two of halogen; nitro; cyano alkyl (from 1 to 10 carbon atoms); alkenyl (from 2 to 10 carbon atoms); alkynyl (from 2 to 10 carbon atoms); cycloalkyl (from 3 to 8 carbon atoms); halo (from 1 to 10 carbon atoms) alkyl; (CH2) zX3R15 in which z is 0 or an integer from 1 to 4, X3 represents 0, S, NR16, CO, COO, OCO, CONR17, NR18C0, OCONR19, R15 represents hydrogen, alkyl (from 1 to 10 carbon atoms) carbon), alkenyl (from 3 to 10 carbon atoms), alkynyl (from 3 to 10 carbon atoms) or cycloalkyl (from 3 to 8 carbon atoms), and R16, R17, R18 and R19 each independently represent hydrogen or alkyl (from 1 to 10 carbon atoms), or R15, R16, R17, R18 or R19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group and R21 represents a hydrogen atom, a halogen atom, an alkyl group (of 1 to 4 carbon atoms) or an alkoxy group (of 1 to 4 carbon atoms).

22. A compound as claimed in Claim 21, in which R 1 represents 2-naphthyl, 4-bromophenyl, 4-benzamidophenyl, 4-methylphenyl, 4-isopropylphenyl, 4-isobutylphenyl, 4-t-butylphenyl, 4-methoxyphenyl, isopropoxyphenyl, 4-cyclopentylphenyl, 4-cyclohexylphenyl, 4- (4-hydroxymethylphenyl) -phenyl, 4- (2-furyl) phenyl, 4- (3-furyl) phenyl, 4- (2-thienyl) -phenyl, - (3-thienyl) phenyl, 4- (pyrrolidin-1-yl) phenyl, 4- (piperidin-1-yl) phenyl, 3-chloro-4-piperidin-1-ylphenyl, 4-benzoyloxyphenyl, 4- (2 -fluorophenyl) phenyl, 4- (3-fluorophenyl) phenyl, 4- (2-formylphenyl) phenyl, 4- (3-formylphenyl) -phenyl, 4- (4-formylphenyl) phenyl, 4- (4-methylphenyl) phenyl or 4- (2-methoxyphenyl) phenyl.

23. A compound as claimed in any one of Claims 15 to 22, wherein R 2 represents methyl, ethyl, propyl, 2-propyl, 2-methylpropyl, cyclohexyl, trifluoromethyl, 2,2,2-trifluoroethyl, chloromethyl, ethenyl, prop-2-enyl, methoxyethyl, phenyl, 4-fluorophenyl or dimethylamino.

24. A compound as claimed in Claim 23, wherein R2 represents ethyl, 2-propyl or dimethylamino.

25. A compound as claimed in Claim 15, which is selected from: N-2- (4- (3-thienyl) phenylpropyl 2-propanesulfonamide; N-2- (4- (3-thienyl) phenylpropyl) ethylsulfamide N-2- (4-cyclopentylphenyl) propyl 2-propanesulfonamide; 2-propanesulfonamide of N-2- (4- (4- (2-methanesulfonamidoethyl) phenyl) phenyl) propyl; 2-propanesulfonamide of N-2- (4- (5-bromo- [1, 2, 4] oxadiazol-3-yl) phenyl) propyl; 2-propanesulfonamide of N-2- (4- (5- (2-methyl) tetrazolyl) phenyl) propyl; N-2- (4- (3- (5- (2-hydroxy) ethyl) isoxazolyl) phenyl) propyl 2-propanesulfonamide of N-2- (4- (4-aminophenyl) phenyl) propyl 2-propanesulfonamide; 2-propanesulfonamide of N-2- (4- (5- (3-bro o) isoxazolyl) phenyl) propyl; N-2- (4- (2-pyridyl) phenyl) propyl 2-propanesulfonamide; 2-propanesulfonamide of N-2- (4- (4- (2- (acetamido) ethyl) phenyl) phenyl) propyl; N-2- (4-N- (benzamido) phenyl) propyl 2-propanesulfonamide; 2-propanesulfonamide of N-2- (4-N- (4-ethylbenzamido) phenyl) propyl; 2-propanesulfonamide of N-2- (4-N- (cyclobutylcarboxamido) phenyl) propyl 2-propanesulfonamide of N-2- (4-N- (5-isoxazolylcarboxamido) phenyl) propyl; 2-propanesulfonamide of N-2- (4-N- (chloronicotincarba ido) phenyl) propyl; 2-propanesulfonamide of N-2- (4-N- (piconioylcarbamido) phenyl) propyl; 2-dimethylsulfamide of N-2- (4-N- (benzamido) phenyl) propyl; N-2- (2-thien-3-yl-5-thienyl) propyl 2-propanesulfonamide; 2-Propanesulfonamide of (+) - N-2R- (4- (3-thienyl) phenyl) propyl, and pharmaceutically acceptable salts thereof.

26. A pharmaceutical composition, which comprises a compound as claimed in any one of claims 15 to 25 and a pharmaceutically acceptable carrier or diluent.

27. A process for the preparation of a compound as claimed in any one of claims 15 to 26, characterized in that it comprises reacting a compound of the formula R1- - C "'NH2 II R5 R7 with a compound of the formula R¿S02X III wherein X represents a group or residual atom, followed when necessary and / or desired to form a pharmaceutically acceptable salt. SUMMARY OF THE INVENTION The "glutamate receptor function in a mammal can be enhanced by using an effective amount of a compound of the formula R1-L-NHS02R2 I, wherein, R1 represents a substituted or unsubstituted aromatic or heteroaromatic group; R2 represents alkyl (from 1 to 6 carbon atoms), cycloalkyl (of 3 to 6 carbon atoms), fluoroalkyl (of 1 to 6 carbon atoms), chloroalkyl (of 1 to 6 carbon atoms), alkenyl (of 2 to 6 carbon atoms) ), alkoxy (from 1 to 4 carbon atoms) alkyl (from 1 to 4 carbon atoms), phenyl which is substituted or unsubstituted by halogen, alkyl (from 1 to 4 carbon atoms) or alkoxy (from 1 to 4 carbon atoms), or a group of formula R3R4N in which R3 and R4 each independently represents alkyl (of 1 to 4 carbon atoms) or, together with the nitrogen atom to which they are attached, form an azetidinyl group, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocini and L represents an alkylene chain of (2 to 4 carbon atoms) which is substituted or unsubstituted by one or two substituents independently selected from alkyl (from 1 to 6 carbon atoms), aryl (from 1 to 6 carbon atoms) alkyl, alkenyl (of 2 to 6 carbon atoms), aryl (of 2 to 6 carbon atoms) alkenyl and aryl, or by two substituents which together with the carbon atom or carbon atoms to the which are attached, form a carbocyclic ring of (3 to 8 carbon atoms); or a pharmaceutically acceptable salt thereof. Also disclosed are novel compounds of the formula (I), processes for preparing them and pharmaceutical compositions containing them.