MXPA99006719A - Device for dispensing a fluid or powdery product at a distance - Google Patents

Abstract

La invención se refiere a un dispositivo para pulverizar o de administrar un fluido o producto en polvo sobre una superficie a tratar y/o un elemento de entrada (50), que comprende:un miembro de administración (1), que comprende un orificio de administración (31), estando asociado dicho miembro de administración con un recipiente (2) que contiene dicho producto y que se mueve entre una posición inoperante y una posición de administración y medios de accionamiento para mover dicho miembro de administración (1) hacia su posición de administración a fin de suministrar una dosis de producto. La invención se caracteriza porque el dispositivo comprende además, medios medidores de distancia (20) movibles entre una posición de inoperante y su posición de uso y dispuestos en su posición de uso de manera tal que en el momento de cada uso del dispositivo, el orificio de administración (31) es ubicado a una distancia fija predeterminada de la superficie a tratar y/o el elemento de entrada (50), regresando el movimiento de dichos medios para medir la distancia (20) de su posición de uso hacia su posición inoperante a dicho miembro de administración (1) hacia su posición inoperante.

Description

DEVICE FOR ADMINISTERING A FLUID OR POWDER PRODUCT AT A DEFAULT DISTANCE Field of the Invention The present invention relates to a device for administering a fluid or powder product and more particularly it refers to a device provided with a means that allows its use to a certain distance from the place to be treated. BACKGROUND OF THE INVENTION Document FR-2 682 305 discloses a mechanically driven device for spraying or administering a fluid. In this device, a pump is accommodated by means of an actuation spring, the device comprising means for locking the spring, starting means and a cover for protecting the housing and provided with means for rearrangement of the device that begin to operate at the moment of the closing of said cover. Because it is operated independently of the user who operates the previous device in a satisfactory manner, in particular by guaranteeing a capacity for reproducing the dose, it does not allow to meet certain requirements that may arise depending on the type of substance supplied and the type of substance supplied. type of use of the device.

- Thus, for certain substances, for example for substances for systemic use such as substitutive hormone therapies, the surface to be sprayed must be defined as precisely as possible in order to reproduce the bioavailability. In particular, in the case of a transdermal use, it is important to administer the sprayed liquid over a predetermined and reproducible homogeneous surface to favor reproducible absorption by the skin. On the other hand, in the case of its use in ophthalmology, it is important, in order to favor compliance, to do what is necessary so that the substance, for example the drop of liquid, reaches the eye with the same dynamic condition. Furthermore, in the case of pulmonary use, it is sometimes important, in order to reduce the side effects, to make only the small sized pulverized particles are aspirated by the patient and to prevent large particles, which can not be inhaled due to their size , they are deposited in the mouth of the patient, being able to generate adverse effects, such as for example the candidiasis. To achieve this, it would be necessary to spray at a sufficient distance so that the large and heavy particles do not touch the mouth, but small enough so that small particles can be sucked. SUMMARY OF THE INVENTION The present invention has the purpose of supplying a substance administration device that satisfies the previously mentioned requirements and does not have the aforementioned drawbacks. In particular, the present invention has the purpose of providing a substance administration device with which the efficacy and / or the therapeutic benefit of the substance administered is maximum. The present invention also has the purpose of supplying a substance administration device which guarantees simultaneously the reproducibility of the dose, the reproducibility of the surface to be treated and the reproducibility of the dynamics of the dosed substance, that is to say, guarantee the reproducibility of the action and the efficacy of the substance in the patient. The present invention also has the purpose of supplying a device such as to favor the observance and / or optimize the bioavailability and / or reduce the side effects. The present invention also has the purpose of supplying a device such that it is simple to make and use and that especially ensures the user maximum efficiency in each drive. The present invention thus provides a device for administering a fluid or powder on a surface to be treated and / or in an organ having an inlet, the device comprising an administration member, comprising, an orifice of administration, being related. said administering member with a container containing the substance to be administered and moving between a rest position and a position of administration; and actuating means for moving said administration member to its administration position in order to release a dose of substance, the device is characterized in that it further comprises: distance calibrating means, movable between a rest position and its position of use and disposed in their position of use, such that at the time of each use of the device, the administration orifice is located at a predetermined fixed distance from the surface to be treated and / or from the organ presenting an entrance, the act of moving said distance calibrating means from its position of use towards its rest position, causes said administration member to return from its management position to its rest position. Preferably, said actuation means comprise elastic means, acting on the administration member, when it is in rest position, to return it to an administration position where it releases a complete dose of substance; locking means of said resilient means for maintaining the administering member in its rest position and starter means operable by the user to release said locking means and thus bring the administering member to its management position. In this way, the start and administration of the dose are independent of the driving force and the repribility of the dose is guaranteed, even when the user is very weak. As an advantage, said distance calibrating means comprise reshaping means which, when the distance calibrating means are brought from their use position towards their rest position, act on the administering member to return it to its own rest position, against the force of elastic means, after which these elastic means are locked by said locking means. Advantageously, said distance calibrating means are realized in the form of a casing comprising a cover, sealing said cover, the administration orifice of the administration member and said envelope covering said starting means, thus preventing an actuation of the device. in the resting position of said distance calibrating means. The device of the invention then also allows to protect the administration orifice during storage, for example, against dust and to prevent an undesired actuation of the device. Preferably, said distance calibrating means are permanently connected to said device, the movement of said distance calipers being constituted by the distance between the rest position and its position of use, by a translation parallel to the central axis of the device and by a rotation around it. of an axis perpendicular to the central axis of the device, said reshaping means acting during said translation movement, when the distance calibrating means return to their rest position. As an advantage, said distance calibrating means comprise two legs connected to the body of the device, said legs sliding in two grooves made in said body, said legs also being able to rotate approximately 90 ° about an axis of rotation arranged transverse to the axis. central of the device at the level of the upper extremities of the two slots. Preferably, the device comprises upstream of said administration orifice, an ejector that allows defining the spatial configuration of the spray of the substance dose. This also allows to predetermine the surface to be treated and repre it exactly on each drive. As an advantage, the surface to be treated and / or the entrance organ is a part of the human body. Also as an advantage, the administration member is a bomb. Advantageously, the administration member is a metering valve. As an advantage, the elastic means are made in the form of a spring. According to an advantageous embodiment, the administration device is a powder administrator, such as an active or passive inhaler. Of course, it can be done with any other type of dust manager. According to an advantageous embodiment of the invention, said distance calibrating means are adapted to rest on the body of the patient, near the surface to be treated, the substance acting transdermally and / or systemically on said surface to be treated. As an advantage, the substance comprises the substitution hormones. Also as an advantage, the substance comprises estrogens. In another advantageous embodiment of the invention, the substance is a liquid, the surface to be treated is an eye, and said distance calibrating means are adapted to rest under or around said eye. In another advantageous embodiment of the invention, said distance calibrating means are adapted to rest on or around the mouth of the user, the substance being distributed inside said distance calibrator means and the length of said distance calibrator means being determined. in such a way that only the particles of finely powdered substance reach the mouth, the larger particles falling due to the effect of their weight in said distance calibrating means before reaching the mouth. BRIEF DESCRIPTION OF THE DRAWINGS Other features and advantages will appear from the following detailed description of an embodiment of the invention, by way of non-limiting example and described with reference to the accompanying drawings in which: Figure 1 is a schematic view in cutting, of a particular particular embodiment of the invention which represents the device in the closed state of the cover. Figure 2 is a schematic sectional view of the device of Figure 1 with the cover in the position of use. Figure 3 is a schematic perspective view of the device according to a particular embodiment of the invention, with the cover in position of use, and Figures 4a and 4b schematically show two variants of use of the device of the invention. DETAILED DESCRIPTION OF THE INVENTION The present invention is applied to any device for spraying or administering a fluid or powder, comprising a delivery member, such as a pump or metering valve, associated with a container that contains the substance, said administration member an administration hole.

The device further comprises means for actuating said administration member for administering a measured amount or "dose" of substance and, according to the invention, distance calibrating means which, in their position of use, are arranged so as to be determined in each use of the device. device a fixed predetermined distance between the administration hole and the surface to be treated and / or an entrance organ. By surface to be treated, is meant any part, especially of the human body, capable of receiving the pulverized substance and in particular, areas of the skin, mouth, nose, eyes or lungs of the user. By "entrance organ" is meant any opening of the human body on which the distance measuring means are supported when the substance is intended for an internal part of the body. In this way, for example, when the surface to be treated is the lungs, it is the mouth that acts as the entrance organ. Although the application of the invention is general, it will be described hereinafter with reference to a particular embodiment in which the invention represents an improvement of the spray device described in document FR-2 682 305. This document FR-2 682 305 is then incorporated into the present invention, by way of reference with regard in particular to the operation of the device, namely, in particular, its starting independent of the driving force. With reference to figures 1 and 2, the device comprises a pump 1 mounted on a container 2 and disposed inside a case 4, said pump 1 moving between a rest position and an administration position, in which it releases a dose of substance. To achieve this, it comprises actuating means, preferably mechanical, comprising elastic means such as a spring 11 acting on the pump 1 when it is in its rest position, to make it be placed in its administration position; locking means 5, 6 blocking said elastic means 11 and keeping the administration member 1, ie the pump 1, in its rest position and starting means 5, 17 to release said locking means. In this way, when the user operates said starting means 5, 17, the pump 1 is carried by the spring towards its administration position in which it releases a dose of substance through its administration orifice 31. Preferably, the The spring is arranged between a lower end adapter 10 fixed to the body 9 of the apparatus and a movable support element 15 on which the container 2 rests. In this way, when the starting means are operated by the user, the user element support 15 causes the container, the case and the pump 1 to move towards the top of the figures under the effect of the force of the spring 11, so that the pump is operated.

As illustrated in FIGS. 1 and 2, the locking and locking means advantageously comprise a pin 5 which is locked in an opening 6 secured to the body 9, the pin 5 being secured with an elastic leg 17 fixed to said case 4 surrounding the container 2 and the pump 1. Said pin 5 is then carried by the elastic leg 17 towards its locked position where the spring 11 locks. According to the invention, the device comprises distance measuring means 20 which in position use allow to determine and fix the distance between the area to be treated and / or the input 50 and the administration orifice 31. Preferably, as shown in the figures, the distance measuring means 20 are formed by the casing 20 adapted with its cover 21, described in document FR-2 682 305. In this way, in its rest position, said distance calibrating means closes said administration hole 31 of the pump 1 pair to protect it, for example, against dust and also advantageously cover the starting pin 5, thus preventing an unwanted or untimely activation of the administrator. In order to be able to use the administrator, said distance measuring means 20 must be removed. To do so, the casing 20 must advantageously exert first a translation movement, then a rotation movement. Thus, as seen in particular in Figure 3, the casing 20 comprises two legs 22 permanently connected to the body 9 of the administrator, said legs 22 sliding with translation movement in the corresponding grooves 25 made in the body 9, so that when it is desired to use the apparatus, the envelope 20 is first lifted with translatory movement in a direction parallel to the central axis of the administrator, then it is rotated, advantageously 90 °, about an axis transverse to said central axis of the administrator. This leads to the position shown in FIGS. 2 and 3. Likewise, after the use of the administrator, the envelope 20 is rotated advantageously first around its axis of rotation, then pressure is applied in a direction parallel to the central axis of the administrator to again slide the legs 22 into the grooves 25. During this movement of translation, the rearranging means 28 provided in the envelope 20, pass through one or more openings 38 in the body 9 and are integral with the case 4 to move it to the resting position of the pump 1 against the force of the spring 11. When the pump reaches its rest position again, the spring 11 is compressed and the pin 5 under the effect of the elasticity of the elastic leg 17 engages in the opening 6 of the body 9 to lock the pump in its rest position. The device is then ready for later use. It is to be understood that the invention is not limited to the embodiment described above and that, on the contrary, the invention applies to any type of administrator comprising a prestressed pump and distance gauging means that also ensure the rearrangement of the pump. These distance measuring means can be moved in relation to the apparatus in any suitable manner provided that it is possible to define, at the time of use of the device, a reproducible surface to be treated, guaranteeing each time the same distance between the administration orifice and the surface to be treated and / or the entrance organ. Furthermore, according to the invention, said distance calibrating means also ensure, when they are brought to their rest position, the rearrangement of the pump or its drive device, as described above, when referring to an advantageous embodiment. Preferably, the device further comprises an ejector 30 disposed near the administration hole 31 and intended to reproducibly configure the spraying of the substance dose. In this way, in combination with a fixed spray distance, the device of the invention also allows to obtain a fixed and reproducible administration of the dose of the substance on the surface to be treated and / or the entrance organ. The apparatus shown schematically in Figures 1, 2 and 3 is particularly intended for transdermal use, where a suitable substance must be administered on a surface to be treated corresponding to a part of the skin of the patient. In this application, the distance measuring means 20 rest on the body of the patient, near the surface to be treated 50 in order to accurately determine the distance between the administration orifice 31 and the surface to be treated and thus obtain a surface to be treated. 50 reproducible in the manner proposed. The substance in this case can be a hormone substitution therapy, for example constituted by estrogens. Figures 4a and 4b represent very schematically other possible uses of the device of the invention. Thus, with reference to figure 4b, the device can be used in the field of ophthalmology to administer a liquid substance in an eye 50. In this case, said distance calibrating means 20 preferably rest under or around said eye 50.

In Figure 4a, the device of the invention is used to deliver a liquid or powder substance into the lungs of the user. In this case, the distance measuring means 20 rest on the entrance member, that is to say on the mouth 50 of the user. Thus, in this mode of use, the substance is administered inside said distance measuring means 20, the length of said distance measuring means being determined in such a way that only finely pulverized particles of substance fill the mouth 50. , which allows to eliminate the larger particles, which by themselves, fall by their own weight inside said distance measuring means 20 before reaching the mouth 50. This is represented in figure 4a by the dotted line. Of course, variants of embodiment of the device of the invention can be used provided that they fulfill the same functions mentioned above for each form of use. The device according to the invention then makes it possible to comply optimally with the aforementioned requirements. Therefore, when the device is used in the field of almology, the distance gauge that is placed under or around the eye to be treated, guarantees the proper functioning of the device and ensures that the drop - reach the eye well, thus favoring the observance. On the other hand, in the case of a transdermal use, the distance calibrator allows to optimize the bioavailability by positioning the device always at an equal distance from the skin, so that a homogeneous and reproducible treated surface is achieved. Furthermore, in the case of pulmonary use, the distance calibrator makes it possible in particular to reduce side effects by allowing the large particles to be trapped and only small particles to pass through.

Claims (15)

1. - NOVELTY OF THE INVENTION Having described the present invention is considered as a novelty and therefore the content of the following claims is claimed as property. A device for administering a fluid or a powder on a surface to be treated and / or in an organ having an inlet, the device comprising: an administration member, having an administration orifice, said administration member being associated with a container containing the substance to be administered and moving between a resting position and a position of administration; and driving means for moving said administration member to its administration position in order to administer a dose of the substance; characterized in that the device further comprises: distance measuring means movable between a rest position, - where they prevent the actuation of said administration member and a position of use, where they cooperate with the surface to be treated and / or the organ that presents an entrance, in such a way that the administering orifice is located at a predetermined fixed distance from said surface to be treated and / or from said organ having an entrance the act of moving said caliper means away from its position of use toward its position of Rest, after actuation of the management member, causes said administering member to return from his management position to his resting position. A device according to claim 1, characterized in that said actuating means comprise elastic means, acting on the administering member, when it is in the rest position, pushing it towards the administration position in which it administers a measured quantity of the substance in complete locking means for securing said resilient means to keep the administering member in its rest position and starter means operable by the user to release said locking means and thus place the administering member in his management position. A device according to claim 2, characterized in that said distance calibrating means include rearrangement means which, when said distance calibrating means are returned from their use position to their rest position, act upon the administering member to return it. towards its own rest position, against the force of the elastic means, after which said elastic means are locked by said locking means. A device according to claim 3, characterized in that said distance calibrating means are implemented in the form of an envelope comprising a cover, said cover sealing in the rest position, the administration orifice of the administration member and covering said envelope in the rest position said starting means, thus preventing the actuation of the device. A device according to claim 3 or 4, characterized in that said distance calibrating means are permanently connected to said device, the movement of said distance calibrating means being constituted between the rest position and its position of use by a translation movement parallel to the central axis of the device and a rotational movement about an axis perpendicular to the central axis of the device, said reshaping means acting during said translation movement when the distance calibrating means are returned to their rest position. A device according to claim 5, characterized in that said device comprises a body, said distance calibrating means comprise two legs connected to the body of the device, said legs sliding in two slots provided in said body, said two legs being further able to rotate about 90 ° about an axis of rotation extending transversely to the central axis of the device at the level of the upper extremities of the two grooves. 7. A device according to any of claims 1 to 6, characterized in that it includes, upstream of said administration orifice, an ejector which thus defines the spatial configuration with which the dose of the substance is sprayed. 8. A device according to any of the preceding claims, characterized in that the surface to be treated and / or the organ having an entrance is a part of the human body. A device according to any of the preceding claims, characterized in that the administration member is a pump. 10. A device according to any of claims 1 to 8, characterized in that the administration member is a metering valve. 11. A device according to any of the preceding claims, characterized in that the elastic means are implemented in the form of a spring. 12. A device according to any of the preceding claims, characterized in that the administration device is a powder manager. 13. A device according to any of claims 1 to 12, characterized in that said distance calibrating means are adapted to rest on the body of the patient, near said surface to be treated. A device according to any one of claims 1 to 11, characterized in that the administration device is a fluid manager, the surface to be treated is an eye and said distance calibrating means are adapted to rest under or around said eye. 15. A device according to any of claims 1 to 12, characterized in that said distance calibrating means are adapted to rest on or around the mouth of the user, the substance being administered inside said distance caliper means, the length of said distance calibrating means in such a manner that only finely powdered substance particles reach the mouth, the larger particles dropping by their own weight in said distance calibrating means before reaching the mouth.