MXPA98010858A - Mechanism of release of operation of a road for a system to apply medicame - Google Patents

Abstract

The present invention relates to a system for dosing medicament, comprising: a bottle for containing a volume of medicament, an elastically deformable body portion in fluid communication with the flask, and containing a piston mechanism and a dosing cavity. of a predetermined volume for collecting medicament from the bottle, the piston mechanism is operatively coupled to the deformable body portion to move along the longitudinal axis of the body portion in concert with the deformation of the body portion along the length of the body portion. its longitudinal axis, a nozzle portion connected to the deformable body portion, to allow the discharge of the medicine collected in the dosing cavity, a housing that retains the vial, the deformable body portion and the nozzle portion, the housing has an anterior wall with an opening for receiving the nozzle portion, the nozzle portion, The body portion and the bottle are configured substantially linearly in that order along a longitudinal axis of the housing from a front end of the housing to a rear end of the housing, a trigger operatively coupled with the housing for driving, by a only trigger actuation movement, the dosing system, to sequentially fill the dosing cavity with medicament from the bottle and subsequently discharge the medicament from the dosing cavity, a lever operatively coupled to the trigger and releasably engaging with the body portion when the body portion is in an environmental portion, the lever can be moved to a first non-environmental position in concert with a first phase of the trigger actuation movement and deforms at least a portion of the deformable body portion, and moves the piston mechanism, along the length axis at the rear end of the housing, the movement of the piston mechanism causes the flow of medicament from the bottle to the dosing cavity to fill the dosing cavity, and a release arm positioned internally in the housing to oppose the lever in the first non-environmental position for decoupling the lever from the deformable body portion upon continuing the driving movement towards a second phase, wherein the deformable body portion returns to the environmental position upon uncoupling the lever and the piston mechanism moves in concert with the deformable body portion towards the nozzle portion to pressurize the medicament into the dosing cavity and discharge the medicament through the bocal portion

Description

MECHANISM OF RELEASE OF DRIVING OF A VIA FOR A SYSTEM TO APPLY MEDICATION BACKGROUND OF THE INVENTION Field of the Invention The invention relates generally to a mechanism for dosing medicament by means of an outlet nozzle, and more particularly relates to a one-way actuation release mechanism for a medicament dosing system, to apply medicament from a dosing bottle of the type that is operated by compression or movement of a trigger.

Description of the Related Art Among the different dispensers for applying medication, a typical medication container includes a storage portion of a flexible bottle, and a nozzle for dosing medication, by squeezing the bottle between its side walls. Another type of medication dispenser is in the form of an accordion or a piston-type dispenser which is actuated by squeezing the bottle between a lower wall and the nozzle, to compress the bottle in its longitudinal direction, instead of being from its sides. The present invention particularly relates to a dosing system which includes that accordion-type or piston-type dispenser, although the present invention can be used in conjunction with other types of dispensers. An example of the piston-type dispenser that expels a pre-calibrated dosage of medicament is described in detail in my United States Patent Number 5,613,957 which is expressly incorporated herein by reference. Normally, several factors contribute to hinder the application of the medication. First, elderly people often find it difficult to hold the doser still, or to squeeze the dispenser in order to apply an appropriate amount of medication. In addition, even for young people who can stop the doser still, the actuation of certain types of dispensers creates problems in the precise application of the medication. For example, the application of medication using a common type of nasal dispenser, requires the initial placement of the tip of the mouthpiece inside the nostril, followed by the removal of the tip of the mouthpiece from the nostril due to compression of the dispenser at the time of expulsion of the medication, which may result in an accidental application of the medication to the eyes or other unintended purposes. Even when the medication is applied appropriately as intended, normally the dosed dose of medicament will vary with the speed and / or the force of the drive of the pump mechanism. In addition, the spray pattern, or pen, of the dosed medicament will also vary with the speed and / or driving force of the pump mechanism. Still another problem associated with the medicament dispensers, is the manufacturing complexity: the pump-type medicament dispensers are currently made of numerous parts, and are highly delicate to assemble. Many of the pump type feeders incorporate springs, which present problems in the manufacturing process for the feeders, due to the tendency of the springs to become entangled. An attempt to solve the above-described problems associated with the application of medicament from a dispenser is described in my United States Patent Number 5,267,986, which discloses a system that includes a cartridge for operating a dosing bottle of type piston or accordion type, in order to apply medication to an eye. The cartridge disclosed in U.S. Patent No. 5,267,986 includes: a housing for stopping the dosing bottle, a telescopic cylinder for compressing the dosing bottle in the longitudinal direction, for loading the bottle with medicament; a safety mechanism to secure the telescopic cylinder and the dosing bottle in the loaded position, against the force of a spring mechanism of the dosing bottle, and a trigger mechanism to release the telescopic cylinder and the dosing bottle from the secured position, with the order to release the medication loaded in the dispenser, by means of the force of the spring mechanism. In order to obviate the need for a separate spring element in the pump mechanism of the dosing bottle ,. a portion of the body of the dosing bottle is made of an elastic material that can be compressed, and which provides a spring force. The two-step process wherein the cartridge disclosed in US Patent Number 5,267,986 loads and subsequently releases the medicament from a dosing bottle, defines the basic operation of a "reverse pump", an example of the which is described in U.S. Patent Number 5,613,957. The dosing system disclosed in U.S. Patent No. 5,267,986, solves the aforementioned problems, making it possible for a user to apply a predetermined dose of medication, regardless of the physical force applied to the dosing system by the user: the strength or release rate of the dosed medication depends on the integral spring element of the system dispenser. Although conventional pump type feeders often utilize compression along the longitudinal axis to release the medicament, the actuation movement of the release mechanism described in US Pat. No. 5,267,986 is preferably achieved in one direction perpendicular to the longitudinal axis of the dosing bottle, to ensure better leverage for the user. Because elastic materials, particularly elastomeric materials and springs tend to exhibit hysteresis, the force of the spring decreases if the spring mechanism is maintained in the compressed position, that is, in the loaded loaded position. Although the deformation of the spring in general is reversible if the spring is returned to, and remain in the unforced state for some period, some of the deformation becomes irreversible, or experiences "drag", if the spring is held in the state compressed beyond a certain threshold time period, whose threshold period varies with the material of the spring. The amount of force loss of the spring depends on the tendency of a particular spring material to "creep", and it is known that metal springs tend to exhibit much less "drag" than plastic springs. The hysteresis of the elastic materials used to form the spring mechanism of the pump described in U.S. Patent Number 5,613,957 is due to the loss of some of the spring property, when the spring element remains in the compressed state for a prolonged period of time. Two examples illustrate the practical implications of the aforementioned hysteresis problem, in relation to the dosing system disclosed in U.S. Patent No. 5,267,986. As a first example, a user places the dosing system in the loaded state, but does not activate the release mechanism for several minutes, due to an interruption. When the release mechanism is finally actuated, the hysteresis of the spring mechanism causes the dosage of the drug released from the calibrated dosage to vary to be released under normal conditions. As a second example, a user puts the dosing system in the loaded state, but subsequently the loaded system is forgotten; the user does not activate the release mechanism for several weeks or months. In this situation, not only the dosage initially released will vary from the calibrated dosage, but the subsequently dosed dosages will also vary from the calibrated dosage, due to a type of permanent deformation, or "drag", that has been presented. In view of the above-described problem of spring deformation, it would be desirable to have a system medication dispenser that allows the user, by means of a single actuation movement, to load the bottle with medication and dose the medication.

SUMMARY OF THE INVENTION It is an object of the invention to provide a medication dosing system that can precisely deliver a small calibrated medicament by means of a single actuation movement, which initially charges the system with medicament, and subsequently doses the loaded medicament. . It is a further object of the invention to provide this system, which includes a drive mechanism for actuating a dosing bottle of the type having a spring configuration, for example, an accordion-type or piston type dosing bottle, whose mechanism of drive requires a minimum force to actuate. It is a further object of the invention to provide a system that substantially eliminates any possibility of the spring elements of the dosing system exhibiting hysteresis of the characteristics of the spring. It is a further object of the invention to provide a system that ensures that dosages discharged from the calibrated dosage do not deviate substantially. It is a further object of the invention to provide a system wherein the actuation movement of the drive mechanism for dosing the loaded medicament is in the direction perpendicular to the longitudinal axis of the dosing bottle, in order to ensure improved leverage for the user, and to avoid the driving movement parallel to the Compression shaft of the spring element. It is a further object of the invention to provide a system that can precisely deliver a small calibrated amount of drug in a stable manner, independently of the physical force applied by the user to the drive mechanism. It is a further object of the invention to provide a system having these characteristics, which has a simple construction, and which is easy to manufacture, by virtue of the small number of components, particularly by virtue of eliminating the need for a spring element separated. It is a further object of the invention to provide a method for delivering precisely a small calibrated amount of medicament, by means of a single actuation movement of a medication dosing system, which initially charges the system with medicament, and subsequently doses the loaded medicament. It is a further object of the invention to provide a method for dosing a small calibrated amount of medicament, by means of a drive mechanism, for operating an accordion-type or piston-type dispenser, whose actuation movement requires a minimum force to actuate.

The above objects are achieved by the present invention, which provides a medicine dosing system, wherein a cartridge or housing for actuating an accordion-type or piston-type dosing bottle is particularly adapted. The dispensing bottle has a front accordion type bellows portion near the front end, a rear section of the liquid storage bottle or chamber at the rear end, and a rear bellows portion located between the front bellows portion and the section after the bottle. A drip cavity or a dosing cavity, which may be located within the front bellows portion or the posterior bellows portion, contains a precalibrated amount of medicament loaded from the liquid storage chamber. In addition, an internal piston mechanism inside the dosing bottle acts in concert with the front and rear bellows portions, to expel the medicament contained in the drip cavity. The housing includes a generally elongated body portion that is adapted to receive the vial doser between an anterior wall and a rear wall of the housing. The rear wall of the housing can form a portion of a rear chamber of the housing, in which case, the rear chamber of the housing receives the rear section of the bottle from the dosing bottle. The front wall of the housing has an opening for exposing the nozzle of the bottle. The nozzle preferably is recessed into the anterior portion of the housing, such that it does not project out of the opening, to prevent any corneal injury in the event of accidental contact of the anterior portion with the eye. Located on the upper portion of the housing, there is a hook-shaped trigger mechanism, with a notched lever located in the inner portion of the housing for extending the front bellows portion, and compressing the rear bellows portion of the dosing bottle in the direction longitudinal, away from the anterior wall of the housing, and towards the posterior chamber. In the case of the exemplary embodiment of the dosing bottle described herein, the extension of the front bellows portion and the compression of the posterior bellows portion, cause a pre-calibrated dose of medicament to enter the dosage cavity located at the front of the dispenser, "loading" the dosing cavity in this way. Continuing the shooting movement, once the notch lever located in the inner portion of the housing has extended the front bellows portion of the dosing bottle by a predetermined distance, the notch lever is decoupled from the front bellows portion by a wedge-shaped arm extending from the rear wall of the housing. Upon uncoupling of the notch lever, the front bellows portion contracts, and the rear bellows portion extends toward the front wall of the housing. In concert with the movements of the front and rear bellows portions, the movement of the internal piston mechanism creates pressure that forces the medicament from the dosing cavity by the anterior nozzle of the dosing bottle.

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a perspective view of a housing of a dosing system in accordance with the present invention. Figure 2 is a detailed cross-sectional side view of the dosing system, including the housing and the dosing bottle in accordance with the present invention, which dosing system is shown in a rest position. Figure 3 is a detailed cross-sectional side view of the dosing system, which includes the housing and the dosing bottle in accordance with the present invention, the dosing system of which is shown in an intermediate position during activation of the firing mechanism. Figure 4 is a detailed cross-sectional side view of the dosing system, including the housing and the dosing bottle in accordance with the present invention, which dosing system is shown in a release position during activation of the firing mechanism.

DETAILED DESCRIPTION OF THE INVENTION The medicament dosing system according to the present invention includes a housing or cartridge 100, shown in Figure 1, which is adapted to house and work in conjunction with an accordion-type dispensing bottle or type of dispenser. piston 200, shown in Figures 2 to 4. Although the present invention is described in conjunction with the dispensing bottle in Figures 2 to 4, the present invention is not limited to this particular dispenser. As shown in Figure 2, the generality of the dosing bottle illustrated at 200 includes a nozzle 2, a front wing 3, a front bellows portion 4, a rear wing 6, a rear bellows portion 7, and a flask section back or liquid storage chamber 8 that contains a storage supply of liquid medication. The dosing bottle 200 can be compressed in the longitudinal direction along the bellows. For this purpose, the front and rear bellows portions 4 and 7, respectively, are constructed of a soft and flexible plastic material, such as the thermoplastic resin sold under the Kraton name of the Shell Company. The elasticity of the dispenser is provided by the spring action of the front and rear bellows. made of Kraton, which has an excellent memory, and serves as an excellent spring. As shown in Figure 3, the dosing bottle 200 further includes a drip cavity, or dosing cavity 31 therein, which contains, when the dosing system is activated, a previously determined volume of fluid to be emitted at In addition, a pump piston 9 is anchored inside the dosing bottle, to the rear wing 6, in such a way that the piston 9 moves in unison with the rear wing .6. In addition, as shown in Figures 2 and 3, conduit channels 10 are provided, which connect the rear section of the bottle 8 with the front bellows portion 4, and the circumferential channels 11 inside the front bellows portion 4, to serving as conduits for the supply of medicament to the drip cavity 31 upon actuation of the dosing system. As will be described in more detail later, a single movement The triggering mechanism of the dosing system carries out in sequence the filling, or loading, of the drip cavity with medication, from the posterior section of the bottle 8, and the subsequent discharge of the medication from the drip cavity through the nozzle 2. shown in Figures 1 and 2, the cartridge or housing 100 of the dosing system according to the present invention has a generally cylindrical shape, although any other convenient form for handling can be employed. The housing 100 includes an anterior wall 104 having a centrally located opening 106 for discharging medication from the nozzle 2, a rear wall 105, wedge-shaped arms 103 extending internally from the rear wall 105, a trigger 101, and an internal notch lever 102, which acts in concert with the trigger 101. As shown in Figure 2, the dosing bottle 200 is placed inside the housing 100, such that, in the rest position, the front wing 3 rests against the front wall 104, the rear section of the bottle 8 rests against the rear wall 105, and the notch lever 102 engages with the rear wing 6. Preferably, the housing 100 is dimensioned in such a way that the doser 200 can be adjusted comfortably inside the housing, with the nozzle 2 completely recessed inside the opening 106 of the wall anterior 104, thereby preventing accidental contact of the nozzle 2 with the eye, as well as preventing contamination of the exterior of the nozzle. In addition, the rear wall 105 can form, in conjunction with the wedge-shaped arms 103, a rear chamber to accommodate the rear section of the bottle 8. From the rest position illustrated in Figure 2, the dosing system in accordance with the present invention is actuated by depressing the trigger 101. In concert with the depression of the trigger 101, the notch lever 102 is moved laterally toward the rear wall 105, while engaging with the rear wing 6, thereby extending the portion of front bellows 4, and compressing the rear bellows portion 7 along the longitudinal axis of the dosing bottle 200, as shown in Figure 3. As can be seen in Figures 2 and 3, when the bellows portion is extended front by means of the notch lever 102, which engages with the rear wing 6, the internal pump piston 9 also moves laterally towards the rear wall 105. The combined movement of the bellows front 4, the pump piston 9, and the rear bellows 7, causes a drop in pressure in the drip cavity 31, and the drip cavity is filled, or "loaded", with drug channeled from the posterior section of the bottle 8, by the duct channels 10 and the circumferential channels 11.

Continuing with the actuation sequence, if the trigger 101 is further depressed, the notch lever 102 is eventually made to reach a position where the notched lever brings it into contact with the wedge-shaped arm 103. At this point , the wedge-shaped arm engages with the notch lever 102, and lifts the notch lever to be released from the rear wing 6, as shown in Figure 4. Upon release from the notch lever 102, the spring action of the front bellows portion 4 and the rear bellows portion 7, causes the rear wing 6 and the pump piston 9 to move towards the front wall 104, as shown in Figure 4. The movement of the pump piston 9 creates pressure that forces the medicament to be discharged from the drip cavity 31 by the nozzle 2. Subsequently, when the trigger 101 is released, the notch lever 102 disengages from the wedge-shaped arm 103, and the spring action of the notch lever 102 allows the notch lever to spring back to the rest position shown in Figure 2. If the medication dosing system according to the present invention is to be used to apply medicament to the eyes, the The lower anterior section of the housing 100 can be additionally equipped with a forward projecting finger 107, which extends from the housing 100 beyond the anterior wall 104, as shown in FIG. shown in Figures 1 and 2. The finger 107 curves upward to define a smooth surface 107a, to engage with the lower eyelid and preferably be covered with a soft jacket. The finger is preferably coated with a material such as Kraton. However, it should be noted that the finger projecting forward 107 is entirely optional, even for the application of the medicament to the eyes. Of course, for different uses of the application of medicament to the eyes, practical considerations will dictate whether the projecting forward finger 107 should be modified, or even if it should omit entirely from the lower anterior section of the housing 100. can see from the above description, an advantage of the dosing system according to the present invention, is that there is virtually no possibility that the front and rear bellows portions exhibit hysteresis of the spring characteristics, since the portions of Front and rear bellows are never "secured" in a deformed state for a prolonged period of time. In accordance with the foregoing, the dosing system according to the present invention ensures that the discharged dosages do not deviate substantially from the calibrated dosage. Another advantage of the dosing system according to the present invention is that the movement of Actuation of the trigger 101 is perpendicular to the longitudinal axis of the dosing system. According to the above, there is little danger of accidentally biting the ball of the eye with the nozzle 2, since the movement to press the trigger is not in the direction of the eye. Yet another advantage of the dosing system according to the present invention is that a single actuation movement of the trigger 101 will make it possible for the user to load the drip cavity, and subsequently discharge the previously calibrated amount of medicament. The dosing system according to the present invention is particularly useful for arthritic patients because the triggering mechanism allows easy release of a drop of medicament, thereby making it possible to more accurately apply the drop of medicament to the eye. Additionally, if the lower anterior section of the housing 10 is equipped with a forward projecting finger 107, the present invention can specifically target the eye sac, an area of low sensitivity and low tear, to apply the medicament, since that the projecting finger 107 allows to expose the eye sac. In the above description, the invention has been described with reference to specific example modalities thereof. However, it will be evident that different modifications and changes can be made to it without departing of the broadest spirit and scope of the invention stipulated in the appended claims. For example, the cartridge or housing may be adapted to be used in conjunction with different types of dosing bottles not specifically described herein, for example, the dispensing bottle described in my United States Patent Number 5,613,957, which it has been expressly incorporated herein by reference. In addition, the spring action provided by the flexible plastic material forming the front and back bellows can alternatively be provided by a longitudinally disposed spring which forces the metering bottle back to the original position upon release from the compressed state. In addition, although the dispensing bottle has been described in this specification having an accordion-type front bellows portion and a rear bellows portion, the dispenser can alternatively incorporate another spring configuration, eg, a single spring element that be integral with the body of the dispenser, or that is formed separately. Additionally, the specific configuration of the trigger 101, the notch lever 102, and the wedge-shaped arm 103, can be modified, for example, the trigger 101 and the notch lever 102 can be formed separately from each other, and / or of the housing 100. The specification and the drawings, according to the foregoing, should be considered in an illustrative sense rather than a restrictive sense.

Claims (26)

1. A system for dosing medication, which comprises: a bottle to contain a volume of medication; an elastic deformable body portion in fluid communication with the bottle, and containing a piston mechanism and a dose cavity of a predetermined volume, for collecting the medicament from the bottle, operatively coupling the piston mechanism with the portion of deformable body, for moving along the longitudinal axis of the body portion in concert with the deformation of the body portion along its longitudinal axis; a nozzle portion connected to the deformable body portion, to allow the discharge of the medication collected in the dosage cavity; a housing retaining the flask, the deformable body portion, and the nozzle portion, this housing having an anterior wall with an opening for receiving the nozzle portion, the nozzle portion, the body portion, and the vial a substantially linear manner, in that order, along a longitudinal axis of the housing, from a front end of the housing to a rear end of the housing; a trigger operatively coupled with the housing for actuating, by a single trigger actuation of the trigger, the dosing system, to sequentially fill the dosing cavity with medicament from the vial, and subsequently discharging this medication from the dosage cavity; a lever operatively coupled with the trigger, and releasably engaging the deformable body portion, when this body portion is in the environmental position, the lever being able to move to a first non-environmental position in concert with a first phase of the actuation movement of the trigger, and deforming at least a portion of the deformable body portion, and moving the piston mechanism, along the longitudinal axis, towards the rear end of the housing, causing this movement of the piston mechanism to flow of the . medication from the bottle to the dosing cavity to fill this dosing cavity; and a release arm internally positioned in the housing, to oppose the lever in the first non-environmental position, to decouple the lever from the deformable body portion, as the driving movement continues until a second phase, wherein the body portion deformable returns to the environmental position at uncoupling from the lever, and the piston mechanism dies in concert with the deformable body portion toward the nozzle portion, to pressurize the medicament into the dosage cavity, and discharge this medication through the nozzle portion.

2. The system according to claim 1, wherein the deformable body portion comprises at least one bellows-shaped portion. The system according to claim 2, wherein the housing is substantially cylindrical, and wherein the trigger engages the housing along a radial surface of the housing. The system, according to claim 3, wherein the trigger is driven in the direction perpendicular to the longitudinal axis of the housing. The system according to claim 4, wherein the trigger and the lever are integrally formed with the housing. The system according to claim 5, wherein the bellows-shaped portion is made of a thermoplastic material. The system according to claim 6, wherein the system further comprises a finger for engaging an eyelid, projecting the finger from an outer surface of the housing, and extending outward to a point anterior to the anterior wall. The system according to claim 1, wherein the housing is substantially cylindrical, and wherein the trigger engages the housing along a radial surface of the housing. The system according to claim 8, wherein the trigger is driven in the direction perpendicular to the longitudinal axis of the housing. The system according to claim 9, wherein the trigger and the lever are integrally formed with the housing. 11. A cartridge to be used in combination with a dispenser to apply medication, the dispenser being of the type that is operated to load from a vial, a calibrated quantity of medicament, into a cavity therein, by deformation of a portion of the body elastic deformable of the dispenser in its longitudinal direction, to a deformed position, and which is actuated to discharge the calibrated amount of medicament from a nozzle, upon subsequent reestablishment of the deformable body portion to its environmental position, the cartridge comprising: housing for retaining the dispenser, the housing having a front wall with an opening for receiving the nozzle of the dispenser; a trigger operatively coupled with the housing for actuating, by a single trigger movement of the trigger, the doser, in order to sequentially fill the cavity with medicament from the vial, and subsequently discharging this medication from the cavity through the nozzle; a lever operatively coupled with the trigger, and releasably engaging the deformable body portion, when this body portion is in the environmental position, the lever being able to move to a first non-environmental position in concert with a first phase of the actuation movement of the trigger, and deforming the deformable body portion along the longitudinal axis toward a rear end of the housing, to the deformed position, this deformation causing the flow of medication from the bottle to the cavity to fill this cavity; and a release arm internally positioned in the housing, to oppose the lever in the first non-environmental position, to decouple the lever from the deformable body portion, as the driving movement continues until a second phase, wherein the body portion deformable returns to the environmental position by uncoupling from the lever, to pressurize the medication into the cavity, and discharge this medication through the nozzle The cartridge according to claim 11, wherein the deformable body portion of the dispenser comprises at least one portion in the form of a bellows. The cartridge according to claim 12, wherein the housing is substantially cylindrical, and wherein the trigger engages the housing along a radial surface of the housing. The cartridge according to claim 13, wherein the trigger is driven in the direction perpendicular to the longitudinal axis of the housing. 15. The cartridge according to claim 14, wherein the trigger and the lever are integrally formed with the housing. The cartridge according to claim 15, wherein the bellows-shaped portion of the dispenser is made of a thermoplastic material. The cartridge according to claim 16, which further comprises a finger for engaging an eyelid, projecting the finger from an outer surface of the housing, and extending outward to a point anterior to the anterior wall. The cartridge according to claim 11, wherein the housing is substantially cylindrical, and wherein the trigger engages the housing along the a radial surface of the housing, and wherein the trigger is driven in the direction perpendicular to the longitudinal axis of the housing. The cartridge according to claim 18, wherein the trigger and the lever are integrally formed with the housing. 20. A system for dosing medicament, which comprises: a bottle for containing a volume of medicament; an elastic deformable body portion in fluid communication with the bottle, and containing a dosing cavity of a predetermined volume, to collect the medication from the bottle; a nozzle portion connected to the deformable body portion, to allow the discharge of the medication collected in the dosage cavity; a housing retaining the bottle, the deformable body portion, and the nozzle portion, said housing having a front wall with an opening for receiving the nozzle portion; and a releasing-actuating drive mechanism, which comprises a trigger and a release mechanism, driving the release-actuation mechanism, by means of a single actuating movement of the actuator. trigger, the dosing system, to fill in sequence the dosing cavity with medicament from the vial, and subsequently download this medication from the dosing cavity, wherein the releasing mechanism deforms at least a portion of the deformable body portion in concert with the first phase of the trigger actuation movement, this deformation of the deformable body portion causing the flow of medicament from the vial to the cavity of dosing, to fill this dosing cavity, and wherein the releasing mechanism is decoupled from the deformable body portion by continuing the actuation movement of the trigger until the second phase, the deformable body portion returning to the environmental position upon uncoupling of the release mechanism, to pressurize the medicament into the dosage cavity, and discharge this medication through the nozzle portion. The system according to claim 20, wherein the release mechanism comprises: a lever operatively coupled with the trigger, and releasably engaging with the deformable body portion, when this body portion is in the environmental position, the lever being able to move to a first non-environmental position in concert with a first phase of the trigger actuation movement, and deforming said portion of the deformable body portion; and a release arm internally positioned in the housing, to oppose the lever in the first non-environmental position, to disengage the lever from the deformable body portion, by continuing the actuation movement of the trigger until the second phase, wherein the portion of deformable body returns to the environmental position by uncoupling from the lever, to pressurize the medication into the dosage cavity, and discharge this medication through the nozzle portion. 22. The system according to claim 21, wherein the deformable body portion comprises at least one portion in the form of a bellows. 2

3. The system according to claim 22, wherein the housing is substantially cylindrical, and wherein the trigger engages the housing along a radial surface of the housing. 2

4. The system according to claim 23, wherein the trigger is driven in the direction perpendicular to the longitudinal axis of the housing. 2

5. The system according to claim 24, wherein the trigger and the lever are formed integrally with the housing. 2

6. A method to apply medication using a system comprising a dispenser and a cartridge housing the dispenser, the dispenser being of the type that is operated to load from a vial a calibrated amount of medicament in a cavity thereof, by deformation of a deformable deformable body portion of the dispenser in its longitudinal direction, to a deformed position, and which is "actuated to discharge the calibrated amount of medicament from a nozzle upon subsequent reestablishment of the deformable body portion to its environmental position, the cartridge being of the type having an anterior wall with an opening for receiving the nozzle of the dispenser, a trigger for actuating, by a single actuating movement, the dispenser, for sequentially filling the cavity with medicament from the vial, and subsequently discharging the medicament from the cavity through the nozzle, a lever operatively coupled with the trigger and releasable coupling with the deformable body portion, in order to deform the deformable body portion in concert with the actuation movement of the trigger, and a release arm internally positioned in the cartridge to decouple the lever from the deformable body portion, comprising this method: deforms the deformable body portion along its longitudinal axis, from its environmental position to the deformed position, by actuating the trigger through a first phase of the single driving movement, to move the lever releasably coupled to the deformable body portion, this deformation causing the flow of medicament from the bottle to the cavity to fill this cavity; decoupling the lever of the deformable body portion in the deformed position, by coupling the release arm with the lever as the driving movement continues until the second phase; and forcing the deformable body portion back into its environmental position by uncoupling from the lever, whereby, restoring the deformable body portion to its environmental state pressurizes the medicament in the cavity, and discharges the medicament through the nozzle portion.