MXPA97007014A - An improved bottle connector assembly for a medicame container - Google Patents

Abstract

The present invention relates to a connector assembly mountable to the neck of the bottle, the neck provided with an edge at an open proximal end of the bottle, the edge having a side portion and a lower face portion away from the open proximal end of the bottle comprising : a collar mountable at the neck edge of the bottle between a first position, from which the collar is removably secured to the neck edge of the bottle, and a second position, where the collar is firmly fixed to the neck edge of the bottle, said collar including a proximal end, a distal end and a side wall therebetween, a plurality of deflectable latches positioned adjacent the proximal end of the collar, each said latch including divertable closure means about the lateral portion of the edge for engagement secured with the lower side of the edge when the collar is in said second position, a mountable protective cover around the portion of the side wall of the collar, the protective cap having an open proximal end, a closed proximal end, and a shield wall formed therebetween, a ring provided adjacent the open proximal end of the cap and connected thereto by a connection breakable by the user, said ring having an annular section with an inner surface cooperable with the closing means of the latches to secure said collar in said second position, the cover having a removable position, wherein the collar is said first position and said cap is mountable to the collar such that the annular section is located distally of said closing means, and a coupling position, wherein the cap is urged in a proximal direction such that the inner surface of said annular section is positioned in cooperating relationship with the means for closing said latches to secure the collar in said second position

Description

AN IMPROVED BOTTLE CONNECTOR ASSEMBLY FOR A MEDICATION CONTAINER BACKGROUND OF THE INVENTION 1. Field of Invention The subject of the invention relates to a connector assembly for a bottle, and more particularly, to a connector assembly for a bottle, which can be safely removed from the bottle after use, to facilitate the disposal of the various components. 2. Description of the Previous Art. Many medications are presented in dry form to achieve a longer storage life. These drugs are reconstituted to the liquid form, by means of a suitable solvent, to be given to a patient. A type of dry medication is a lyophilized medication. In the art, there are numerous ways to store dry drugs, such as lyophilized drugs, in a manner that leads to their reconstitution and delivery. Some of these products are exemplified, for example, by the MONOVIAL © brand prefilled pharmaceutical supply devices manufactured and sold by Becton Dickinson Pharmaceutical Systems of Le Pont de Claix, France. Such systems are more exemplified, for example in U.S. Patent No. 5,358,501, issued to Gabriel Meyer on October 25, 1994. Although there are variations to such systems, in general they include jars made of glass suitable plastic materials, in which A selected dose of a lyophilized drug can be stored. The bottle is usually sealed to prevent deterioration or contamination of the medication. The dried drug can be reconstituted with a liquid solvent a little before use and the solution of the now reconstituted drug can be administered to a patient. Several components are employed with the pre-filled drug-delivery systems described above. For example, the bottles are typically provided with a bottle connector assembly to allow attachment of the bottle to a source of solvent to reconstitute the dried medicament. The same bottle connector is also commonly used to attach the bottle to an intravenous fitting to deliver the reconstituted medication to a patient. Bottle connectors such as those used with the pre-filled drug delivery systems, described above, typically include one or more components necessary for the function of the system. For example, one or more rubber plugs or membrane components for sealing the bottle until such time as access to the drug, in its dry or liquid form, is desired. A fluid transfer instrument, such as a needle or tip, is also provided to provide means for introducing the soap into the bottle and for delivering the reconstituted drug out of the bottle. Generally, a collar component is provided adjacent the edge of the bottle to secure various parts, such as the fluid transfer device and sealing components, associated with the bottle connector.

Depending on the configuration of the pre-filled drug delivery system, the system can be activated by moving the collar with respect to the edge of the bottle, wherein the fluid transfer device and sealing components are fixed relative to the collar, or moving the fluid transfer device and sealing components relative to the bottle, wherein the collar is fixed relative to the edge of the bottle, movably relative to the collar. Accordingly, depending on the configuration, the system can be activated both by causing movement between the collar and the edge, and by causing movement between the fluid transfer device and / or the sealing components relative to the collar. One aspect of the aforementioned systems is that after use, the various components, such as the fluid transfer device, the senator components, and the necklace itself, remain fixed to the bottle. Here, once the medication has been delivered to the patient, the entire system is completely discarded in a sterile manner. Due to the different materials used in the various components, benefits can be realized by configuring a system where the components can be separated from one another, in a safe manner to facilitate their disposal. For example, certain governmental regulations or accepted practices may favor the disposal of the bottle, which contained the drug in its dry and reconstituted forms, separately from the transfer assembly.

R ^ s and E PE lA i YENQif The subject of the invention is directed to a connector assembly for use with a bottle. The bottle includes a bottom wall and a vertical side wall. A shoulder extends internally from the upper end of the side wall and a tubular neck extends upwardly from the shoulder to an open top. An annular rim may extend around portions of the neck that define the top. The portions of the bottle between the tubular neck and the bottom wall define an enclosure within which a lyophilized medicament or a medicament solution can be stored. A novel aspect of the connector assembly according to the present invention is that it is mountable to the neck of the bottle in such a way that it can be safely removed by a practitioner, such that the connector assembly can be disposed of separately from the bottle. The connector assembly can be used with various fluid transfer devices, such as a needle, a tip, or a stinger, as a means for introducing solvent into the bottle and for delivering the reconstituted drug out of the bottle. Various plugs and membrane components may be provided in conjunction with the connector assembly to seal the vial until such time as access to the medicament, in its dry or liquid form, is desired. The connector assembly includes a collar mountable to the neck edge of the bottle. The collar includes a proximal end, a distal end, and a side wall therebetween. A plurality of deflectable latches are provided adjacent the proximal end of the collar. The plurality of deflectable latches include in each one, deviable closing means around a lateral portion of the edge to ensure engagement with the lower face portion of the edge. In one configuration, the closure means may be formed as an interlocked, face-close closure surface provided adjacent to the proximal end of each of the deflectable latches. The protective assembly includes a protective cover mountable around the side wall portion of the collar, which cooperates with the collar to secure the connector assembly to the edge of the vial. The protective cap highlights an open proximal end, a closed distant end, and a protective wall formed therebetween. A ring is provided adjacent the open proximal end of the protective cap. The ring features an annular section with a cooperating inner surface with a structure associated with the deflectable latches and is connected to the proximal end of the protective cap by one or more connectors breakable by the user. In one embodiment, the connections breakable by the user are formed as one or more fragmentable sections formed between the proximal end of the cover and a distal end of the ring. The ring may include a rib element formed at a proximal end thereof. The rib element may cooperate with a structure provided on the deflectable latches to prevent further distal movement of the ring after the collar is urged into closed position with the edge of the jar. The inner surface of the annular section can define a diameter equal to, or slightly smaller than, a diameter defined by a pair of diametrically opposed deviating latches, such that the annular section will apply a clamping force directed internally on one of the latches definable. The internally directed force will retain the collar in a closed position with respect to the edge of the vial. The device can be supplied to a pharmaceutical manufacturer in a manner that allows processing and filling the bottle with a desired medicament. After the medication is poured into the bottle, the collar can be locked securely to the edge of the bottle for shipping to an end user. The collar, together with the fluid transfer device and the various sealing plugs and / or membranes associated with the connector assembly, they are positioned so as to seal the open top of the bottle. The protective cap is then mounted around the side wall portion of the collar. If sterilized ribs provided in an inner portion of the container are provided, they cooperate with the side wall of the collar to provide additional seal security for the medicament retained within the vial, as well as for the various components associated with the connector assembly. A continuous continuous movement of the cap, relative to the collar, will cause the annular section to engage with the deflectable latches, such that the cap and the collar move both very close relative to the edge. The protective action against the collar, and in particular, the ring-section coupling forces of the ring and the derailleurs of the collar, cause the deflectable latches and particularly the closing means associated therewith, to move towards a secure engagement with a lower face portion of the edge. The annular section proceeds to approximate in relation to the collar, in such a way that the inner surface of the annular section is arranged in cover relationship with the deflectable bolts of the collar. The rib element provided at the proximal end of the ring retains the ring in a fixed position relative to the diverting latches in a manner such that the ring can not be subsequently removed in a distal direction. Consequently, internally directed forces are exerted by the annular section on the deflectable latches to keep the collar in closed position relative to the edge. The device can thus be shipped to an end user. The device can be activated by an end user first by removing the protective cover of the annulus by breaking the breakable connections. The fluid transfer device and / or the sealing plugs or membranes provided with the connector assembly may be activated in accordance with their function, and the dried medicament maintained within the reconstituted and supplied bottle.

After the medicament has been delivered, the ring can be displaced proximal in relation to the collar to free the divertable latches from the coupling with the inner surface of the annular section. After these, a force can be applied to the collar to cause the deflectable latches to deviate distantly around the lateral edge section to remove the collar from the bottle. The connector assembly and the ampoule can thus be disposed of separately according to applicable government regulations, or industrial practices.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is an exploded view of one embodiment of a bottle connector assembly according to the present invention. Fig. 2 is a sectional sectional view of the collar taken along line 2-2 of Fig. 1. Fig. 3 is another sectional sectional view of the collar, taken along line 3-3 of Fig. 1. Fig. 4 is a sectional sectional view of the lid, taken along line 4-4 of Fig. 1. Fig. 5 is a perspective view illustrating the lid coupled with the collar , for example, when the bottle and the connector assembly are shipped to a pharmaceutical manufacturer for processing. Fig. 6 is a partial sectional sectional view of the cap coupled with the collar taken along line 6-8 of Fig. 5. Fig. 7 is a perspective view illustrating the cap fitted with the collar, for example, after a drug has been processed by a pharmaceutical manufacturer. Fig 8 is a partial sectional sectional view of the cap fitted with the collar taken along the line 8-8 of Fig. 7 Fig. 9 is a sectional sectional view of the cap coupled with the collar as taken at along line 9-9 of Fig. 7. Fig. 10 is an exploded view illustrating a user separating breakable connections between the lid and the ring in preparation for the use of the device. Fig. 11 illustrates, in perspective view, the activation of the device. Fluid transfer associated with the bottle connector in preparation for a reconstitution of a dry drug maintained within the bottle. Fig. 12 illustrates, in section of cut, a reconstitution operation. Fig. 13 illustrates, in section section, the movement of the annular ring in a proximal direction away from the coupling with the collar in preparation for removing the connector from the vial bottle. Fig. 14 is an exploded view illustrating the removal of the bottle connector from the bottle.

DETAILED DESCRIPTION OF THE PREFERRED MODALITIES A connector assembly according to the subject of the invention is generally identified by the numeral 10 in Fig. 1. The connector assembly 10 is used with a bottle 12, which has a bottom wall 14, a cylindrical side wall 16 which Axtiendie upwardly from the bottom wall 14, a shoulder 18 extending inwardly and upwardly from the end of the cylindrical side wall 16 away from the bottom wall 14, and a cylindrical neck 20 of inside diameter "a" which is extends upwardly from the shoulder 18. The neck 20 ends in an open upper part 22. The upper part 22 is characterized by an annular edge 24 projecting outwardly therefrom. The annular rim 24 is characterized by a side portion 24 a and a lower face portion 24 b.

The bottle 12 is provided with a lyophilized medicament 26 stored therein. The connector assembly 10 functions to securely seal the lyophilized medicament 26 in a vial 12 and to allow a solvent to be added to the flask 12 to mix with the lyophilized medicament 26 and form a medicament solution. The connector assembly 10 further allows delivery of the drug solution to an I V set for administration to a patient. For purposes of illustration, but not limitation, the connector assembly 10 according to the subject of the invention is illustrated with several known components, not limiting the scope of the applicability of the invention described and claimed in the presenter. For example, the connector assembly 10 as described herein, is shown with a fluid transfer device 100 configured as a conventional tip. It will be apparent to the skilled artisan that other fluid transfer devices, such as stinger attachments, a punctured and cannulated needle, or the like, can be employed with the connector assembly 10 of the present invention described herein.

The fluid transfer device 100 may include a structure 106 which serves to retain various seal components of the bottle. Here, a plug 102 is illustrated which serves to seal the neck 20 of the bottle. Also illustrated is a secondary seal 104 which may be located around the fluid transfer device 100. It will be explicitly understood by skilled artisan that other bottle seal devices may be used. In addition, a retractable shield 108 is shown which allows the fluid access device to be guarded in such a manner as to prevent contact by inadvertent touching with the fluid transfer device 100. It will be explicitly understood by the skilled artisan that other devices may be employed. of protection with the connector assembly 10 as described herein. For example, the protection devices described in U.S. Patent No. 5,358,501 can be used with the same effect with the connector assembly described and claimed herein. Turning now to the explanation of connector assembly 10, a generally annular collar 30 is provided. As shown more clearly in Fig. 1-3, the collar 30 has opposite proximal and distal ends 32 and 34, respectively. The proximal end 32 of the collar 30 is defined by a plurality of deflectable latches 36 sized to retain the collar 30 in closed position with respect to the annular edge 24, as well as to allow an end user to safely remove the collar 30 from the edge, when it is desired to discard the connector assembly separately from the bottle. Portions of the collar 30 the ends 32 and 34, proximal and distal define a side wall 33. Within the side wall 33 may be provided an annular projection 38 extended internally and radially having an inner diameter approximately equal to the inner diameter "a" of the neck 20 of the flask 12. The projection 38 may be provided for mounting usable fluid transfer components with a connector assembly of the present invention. The deflecting latches 36, each include a face 35 externally chamfered face-to-face, and a locking surface 37 chamfered internally from a distance. The externally chamfered surface 35 facilitates proximal movement of the collar 30 on the edge 24 for movement of the connector assembly to the closed position with the edge. The closing surface 37, is configured in each of the pivotable latches to fit securely with the lower face portion 24b of the edge, when the collar 30 is locked to the edge. Each of the deflecting latches 36, highlights a coupling surface 38, arranged on an outer portion of the latches. The engaging surface 38 may be formed as an outer portion of the latches 36 in a manner such as to be raised from the plane defined by the side wall 33 of the collar. As seen in Figure 3, a pair of diametrically opposed coupling surfaces 38 define a diameter "X". As illustrated, the latches 36 are preferably formed such that they can not deviate slightly away from a central axis "Z" that runs through the collar 30 before the collar is locked with the edge. A proximal end of a mating surface 38 ends opposite the proximal end 32 of the collar to define a notch 40. A removable safety cap 50 is provided for use with the connector assembly 10. The removable safety cap 50 includes an open proximal end 52, a closed distal end 54, and a shield wall 56 formed therebetween. The cap 50 is configured to fit over the various components, such as the fluid transfer device or safety shield, provided for use with the connector assembly 10. The cap 50 may feature an enlarged skirt portion 58 adjacent the proximal end 52 The skirt portion 58 may highlight one or more senate ribs 60 which contact the side wall 33 of the collar 30 when the cover 50 is placed thereon, to improve maintenance of the sterility of the various components such as the fluid transfer instrument, located within the shield wall 56. The seal ribs 60 may be configured from d <; various visco-elastic materials, such as rubber products, silicone products or the like, to improve the characteristics of maintaining the sterility of the lid 50. If the senate ribs 60 are formed of the same material as the lid 50, it will be It is appreciated that various elastic materials can be applied to the side wall 33 to cooperate with the seal ribs to improve the behavior between the seal ribs and the side wall of the collar. A ring 61 is provided adjacent the proximal end 52 of the protective cap 50. The ring 61 includes an annular section 62 having an inner surface 68. The inner surface 68 defines a diameter "V at least equal to, if not slightly less that, the diameter "X" defined between a pair of diametrically opposed coupling surfaces 38. The ring 61 is post-fixed to the proximal end 52 of the cover by one or more breakable connections 66. As it was mainly disclosed herein, the connections 66 The breakable connections can be formed as one or more fragmentable connections between the ring and the cover.The fragmentable connections can be formed as thin sections of material joining the ring and the cover.However, it will be evident to the expert that other breakable connections, such as the threaded connections, they can also be employed.A lock rib 70 is formed adjacent an open proximal end 64 associated with the ring 61. A slot 71 disposed on the inner surface 68 intermediate between the various connections 66 and the proximal end 64 can be provided. The operation of the connector assembly 10 in conjunction with its various stages will now be described with reference to FIGS. 5-14. Figs. 5 and 6 are illustrative of the connector assembly of the bottle 10 as it could be shipped to a pharmaceutical manufacturer for processing and filling with a given medication 26. For example, the device can be shipped in such a manner that the collar 30 is disposed with respect to the 24 edge of the bottle in a removable way. The closure surface 37 rests in some way adjacent the side portion 24a of the edge of the bottle, without having been placed in a secure engagement with the lower face portion of the portion. 24b from the edge of the bottle. The various sealing components 102, 104 associated with the fluid transfer device 100 may be coupled within the neck 20 of the bottle (not shown). The cap 50 is placed on the collar 30 in such a way that the inner annular surface 68 rests on a side wall portion 33 located distally of the engaging surface 38. It will be seen that the deflectable latches 36 are chamfered in a manner outward and away from the central axis "Z" of the collar 30. The senate ribs 60 of the protective cap are arranged for engagement with the side wall 33 of the collar as previously described. The pharmaceutical manufacturer can remove the cap and collar distally away from the rim of the vial in order to process and otherwise empty a medicament into the vial 12. After the medication 26 has been filled and otherwise processed into the vial , the pharmaceutical manufacturer can secure the bottle connector 10 to the edge of the bottle, as seen in Figs. 7-9. The collar 30 and the cap 50 are first taken back to the positions illustrated in Figs. 5 and 6. After both by the application of a force directed proximally on the protective cap 50, or by application of a force directed distally on the bottle 12, the collar 30 and the protective cap 50 are propelled proximally with respect to the edge 24. Assisted by the chamfered surfaces 35, the collar 10 is propelled proximally from the edge 24b of the bottle, such that the sealing surfaces 37 are urged against the inner face portion 24b of the edge of the bottle. The collar 30 is thus placed in a closed position with respect to the edge 24, and the proximal rear movement of the collar is controlled. The lid 50 continues to move proximally with respect to the collar. The ring 61, together with the protective cap 50, is propelled proximally along the side wall 33 of the collar, with the inner surface 68 of the annulus 62 engaged in a cover relationship with the engaging surface 38 of the divertable latches 36. The lock rib 70 is positioned within the notch 40 located on the proximal edge of the coupling surface 38. The dimensions of the cap and collar can be configured such that when the lock rib 70 is engaged with the notch 40, the proximal end 34 of the collar rests against the inner shoulder 120 of the cap, preventing further proximal movement! of the cap vis-a-vis of the collar. Due to the smaller diameter "Y" of the annulus 62 vis-a-vis the diameter "X" presented by the diametrically opposed coupling surfaces 38, the annulus 62 exerts an internally directed force on the latches. The effect is to securely lock the latches to the edge of the bottle via the secure coupling between the lower face portion 24b of the edge of the bottle and the engaging surface 37 of the deviators. The various components can be configured in such a way that when the collar 30 and the protective 50 are locked to the edge of the bottle, the various sealing elements such as the plug 102 and the secondary seal 104 (not shown) remain arranged in the neck of the bottle in a ready-to-be-activated state. In accordance with this, the vial 10 remains in a ready-to-use sterile state. In order to reconstitute the dried drug 26 maintained in the bottle 12, the end user must separate the breakable connections 66 between the proximal end 52 of the protective cap and the ring 61. As illustrated in Fig. 10, a user , by applying digital pressure to the ring 61, it can either axially twist or pull the cap 50 away from the ring in order to separate the connections 66. The protective cap 50 is simply lifted away from the ring 61, exposing the fluid transfer device and the associated components. The ring 61, by virtue of the lock rib 70, it remains in a secure engagement with the latches 36. It will be appreciated by the skilled artisan that any breakage or breakage in the breakable connections 66 can be used as an obvious means of forcing by the user, ensuring the integrity of the drug 26 kept inside. Figures 11 and 12 illustrate the activation of the fluid transfer device 100 and the associated components in preparation of the reconstituting medicament 26 held within the bottle 12. For example, the protective shield 108 can be moved proximally, causing a proximal movement of the secondary seal 104 and of the retainer 102 towards the interior of the ampoule 12. The effect is to open the path of the fluid 150 between the fluid transfer device 100 and the interior of the bottle 12, allowing the passage of fluid to and from a source of solvent " S ". The skilled artisan will appreciate the mechanisms by which such fluid transfer devices can be employed with the connector of the bottle of the present assembly, for example, by reference to U.S. Patent No. 5,358,501, the disclosure of which is incorporated herein by reference. Assuming now that the drug 26 maintained within the bottle has been reconstituted and a desired amount delivered to a patient, a user will be willing to discard the device, particularly the bottle 12 and the bottle connector assembly 10, in a judicially authorized manner and safely . If desired, the end user can disconnect the bottle connector assembly 10 from bottle 12, allowing both to be disposed of separately.

Referring to Figures 13 and 14, in preparation for safe disposal, a user may wish to reattach any of the security implements provided, such as the security shield 108, to protect the user from an inadvertent touch contact. with the fluid transfer device 100. For example, in the device described by the EU Patent No. 5,358,501, a needle guard is an inherent part of the design. By securely grasping with a non-part of the collar 30, a user exerts a force directed proximally on the ring 61. The ring 61 is caused to slide proximally away from the latches 36, such that the ring will remain freely placed around the neck 20 of the bottle. In the absence of an internally directed force between the interior surface 68 of the annulus and the mating surface 38 of the latches, a user can simply exert a force directed proximally on the collar 30, to remove it from the neck 24 of the bottle. The deflectable latches, assisted by the closure surfaces 37, inwardly bevelled, will slide from their adjustment with the lower face portion 24b of the bottle rim and around the lateral portion 24a of the bottle rim, allowing the removal of the collar 30. . The bottle connector assembly 10, including the fluid transfer device 100 and the sealing components such as the rubber plug 102, are removed from the bottle 12. The fluid transfer device 100 is securely encased by any such safety device. as the shield 108. The bottle 12 can now be disposed of separately from the connector of the bottle 10 in any way conforming to government regulations or industry standards of practice. The various components can be constructed of standard materials in the art. For example, the collar 30, the cap 50, the ring 61 or any of its sub-components can be injection molded from conventional thermoplastics. The fluid access device 10 can be formed from thermoplastics (eg, if the fluid access instrument is formed as a tip or stinger connector, for example), or it can be provided as a cannula made of stainless steel ( if the cannula is sharp) or of a suitable thermoplasic (for example if the cannula is without tip). Various rubbers or elastomeric materials can be chosen for the plugs 102, 104. The bottle can be formed of an appropriate glass or of plastic materials adaptable to the particular medicament held therein. It will be appreciated and understood by those skilled in the art that further and further forms of the invention may be instrumented without departing from the spirit and scope of the appended claims, the invention not being limited to the specific embodiments shown.

Claims (15)

1. A connector assembly mountable to the neck of the bottle, the neck provided with an edge at an open proximal end of the bottle, the edge having a side portion and a lower face portion away from the open proximal end of the bottle, comprising: a collar mountable at edge of the bottle neck between a first position, from which the collar is removably secured to the neck edge of the bottle, and a second position, where the collar is fixedly fixed to the neck edge of the bottle, said collar including a proximal end, a distal end and a side wall therebetween, a plurality of deflectable latches positioned adjacent the proximal end of the collar, each said latch including divertable closure means around the lateral portion of the edge for engagement secured with the underside of the edge when the collar is in said second position. A protective cap mountable around the portion of the side wall of the collar, the protective cap having an open proximal end, a closed proximal end, and a shield wall formed therebetween, a ring provided adjacent the open proximal end of the cap and connected thereto by a connection breakable by the user, said ring having an annular section with an inner surface cooperate with the closing means of the latches to secure said collar in said second position, the lid having a removable position, where the collar is in said first position and said cap is mountable to the collar such that the annular section is located distally of said closing means, and a coupling position, wherein the cap is urged in a proximal direction such that the surface The interior of said annular section is positioned in cooperative relationship with the means for closing said latches to secure the collar in said second position. The connector assembly of Claim 1, wherein said protective cap is removable from said coupling position upon release of the breakable connection by the user between said ring and said protective cap. 3. The connector assembly of Claim 1, wherein said breakable connection by the user comprises one or more fragmented sections located between the proximal end of said protective cap and said ring. 4. The connector assembly of Claim 1, wherein said breakable connection by the user comprises a threaded connection between the proximal end of said protective cap and said ring. 5. The connector assembly of Claim 1, wherein said securing means comprises: a closure member located at a proximal end of the cieager means; and a coupling surface secured in functional relation to said closure element and cooperable with the inner surface of said annular section, wherein when said ring is urged in the proximal direction, the inner surface of said annular section will be placed in covering relation with the coupling surface for transmitting an internally directed force to said closure element for retaining it in a secured relationship with the underside of said edge. 6. The connector assembly of Claim 5, within which the inner surface of said annular section includes a rib element adjacent the proximal end of the ring, wherein said rib element is cooperative with said adjusting surface when the ring is driven in the proximal direction for proximal to prevent removal of said ring in a distal direction. 7. The connector assembly of Claim 6, wherein said annular section is removable from said engaging surface in a proximal direction wherein in the absence of said internally directed force on said closure element, said closure elements are deflectable around the lateral portion of the edge to remove the bottle collar. 8. A connector assembly mountable to the neck of a bottle, the neck provided with an edge at an open proximal end of the bottle, the edge having a side portion and a lower face portion away from the proximal open end of the bottle, comprising: a mountable collar at the edge of the neck of the bottle between a first position where the collar is removably secured to the neck edge of the bottle, and a second position, where the collar is fixedly secured to the neck edge of the bottle, said collar including a proximal end, a distal end, and a side wall therebetween, a plurality of deflectable latches provided adjacent the proximal end of the collar, each said latch including closure means comprising a snap-off hook that is deflectable around the lateral portion of the edge for secured engagement with the lower edge side when the collar is in said second position and a mating surface arranged in functional relation with said closing hook, wherein a pair of opposing coupling surfaces defines a first diameter; a protective cap mountable around the portion of the side wall of the collar, the protective cap having an open proximal end, a closed distal end, and a shield wall formed therebetween, a ring provided adjacent the open proximal end of the cap and connected thereto by one or more connections breakable by the user, said ring having an annular section defining an inner surface with a second diameter equal to or less than the first diameter of the pair of opposite coupling surfaces, said inner surface cooperable with the means for closing the latches to secure said collar in said second position, the cover having a removable position, wherein the collar is in said first position and said cover is mountable to the collar such that the annular section is located distally of said means of closure, or a coupling position, wherein the lid is propelled in a proximal direction such that the The inner surface of said annular section is positioned in cooperating relationship with the engaging surface of the closing means of said latches to exert a force on the closing hooks, said closing hooks driving in secure engagement with the lower side of the edge for secure the collar in said second position. 9. The connector assembly of Claim 8, wherein the side wall of the collar defines a first plane and wherein the engagement surface of said adjustment means defines a second plane not co-planar with the first plane of the side wall. 10. The connector assembly of Claim 9, wherein said deflectable latches are chamfered from the first plane of said side wall. 11. The connector assembly of the Claim, wherein said annular section defines a first diameter and a pair of opposite latches define a second diameter, wherein the first diameter is equal to or less than the second diameter. 12. The connector assembly of Claim 8, wherein the inner surface of said annular section includes a rib element adjacent the proximal end of the ring, wherein said rib element is cooperable with said engaging surface when the ring is driven in the direction proximal to prevent removal of said ring in a distal direction. 13. The connector assembly of Claim 12, wherein said annular section is removable from said engaging surface in a proximal direction, wherein in the absence of said internally directed force on said engaging surface, said closure hooks are deflectable around the lateral portion of the edge to remove the bottle collar. 14. The connector assembly of Claim 8, wherein said collar is formed of a thermopipe material. 15. The connector assembly of Claim 8, wherein said protective cap is formed of a thermo-elastic material. EXTRACT OF DESCRIPTION A connector assembly provided for efficient flow of liquid in and / or out of a bottle, such as a bottle containing a lyophilized medicament. The connector assembly features a collar mountable to the edge of the bottle in a locked position and subsequently removable by an end user when disposal of the device is desired. A protective cover mountable on the collar includes an annulus-type ring at its proximal end, which mounts on the closure structure associated with the collar. The ring is secured to the protective cap via one or more breakable connections by the user. As the cover is propelled proximally, the ring places the collar in the locked position with the edge of the bottle, exerting a force directed internally on the closure structure to secure the collar to the edge of the bottle. The lid can be separated from the ring in its connections breakable by the user, and the device used in its ordinary manner. When scrapping is desired, the ring can be propelled proximally out of engagement with the locking structure of the collar. The collar can then be removed from the bottle to facilitate separate disposal of these components.