MXPA97006420A - A preparation for the bleaching of teeth or for the treatment of skin lesions and muc membrane disorders - Google Patents

Abstract

The present invention relates to a method for the preparation of a preparation for teeth whitening or for the treatment of skin lesions and disorders of the mucous membrane, in which method, at least the following is combined: (a) a gel or paste in which a component (i) is present, the component (i) consisting of at least one cation An + and an anion OmX-, wherein A is a metal of group 1 or 2 of the periodic table, n = 1 or 2, X is a halogen atom and M = 1-4, and (b) a gel or paste in which a component (ii) is present, the component (ii) consisting of at least one An + cation and one anion [BpOq] r-, where A is a metal of group 1 or 2 of the periodic table, p = 1-4, q = 1-8 and r = 1

Description

METHOD FOR PREPARING A PREPARATION FOR THE BLEACHING OF TEETH OR FOR THE TREATMENT OF SKIN INJURIES AND MUCOSA MEMBRANE DISORDERS FIELD OF THE INVENTION The present invention relates to a method for the preparation of a preparation for the bleaching of teeth or for the treatment of skin lesions and disorders of the mucous membrane. BACKGROUND OF THE INVENTION In cosmetic dentistry, various products and techniques are used to whiten both living and non-living teeth. Non-living teeth are dead teeth that no longer contain a nerve or that contain a nerve that is no longer functional, for example as a result of the well-known treatment of root canals. Live teeth are living teeth that still contain a functional nerve. The bleaching of the teeth can be carried out, for example, using the Hi-Lite product, which is marketed by Shoofu Dental Corporation. This product contains concentrated hydrogen peroxide (35%) as an active ingredient and is applied as such to the tooth to be bleached, after which it is allowed to act for 8-10 minutes. During this period the whitening of the tooth takes place as a result of the so-called chemical activation. Bleaching can be accelerated under the influence of light. In this case, the tooth to which the product has been applied is irradiated using a special lamp, as a result of which the period needed to bleach up to 2-3 minutes is shortened. This last method for whitening teeth is described in greater detail in an article by F.N. Hanosh and G.S. Hanosh in J. Esthet. Dent. 4 (1992) 90-95. A significant disadvantage of the Hi-Lite product is that it contains an aggressive chemical, hydrogen peroxide, which, moreover, is present in a high concentration (35%) in the product. The product therefore has to be handled carefully. When handling this product should also avoid contact with the skin and it is highly recommended to use protective gloves and lenses. In addition, this product has not been found to have a durable bleaching action, ie the effect (durability) of the treatment clearly declines after a few months. Other products, such as Nite-White, which is marketed by New Smile Care-Zahnkosmetic GmbH, contain carbaimide peroxide (CO (NH2) 2H202) as an active constituent. According to the state of the art, however, it is found that although an appreciable color change occurs after the active treatment of the tooth to be bleached, this color change has disappeared viirtually and completely after only one week. Effective agents are not described in the state of the art for the treatment of skin problems and disorders of the mucous membrane, in particular lesions. SUMMARY OF THE INVENTION The spirit of the present invention is to provide a solution to the problems described above by using a preparation for bleaching teeth, the preparation not containing any aggressive chemical substance. Another spirit of the present invention is to provide an effective agent for the treatment of skin problems and disorders of the mucous membrane, in particular injuries. The present invention, therefore, relates to a method for the preparation of a preparation for teeth whitening or for the treatment of skin lesions and mucosal membrane disorders, in which method, at least the following are combined: ) a gel or paste in which a component (i) is present, the component (i) consisting of at least one cation An + and an anion 0BX ", wherein A is a metal of group 1 or 2 of the periodic table , n = lo 2, X is a halogen atom and m = l-4, and (b) a gel or paste in which a component (ii) is present, the component (ii) being composed of at least one An + cation and an anion [Bp0q] r ~, where A is a metal of group 1 or 2 of the periodic table, p = l-4, q = l-8 and r = l-3. The term gel or paste is used to define materials that have a characteristic viscosity and flow that are comparable to those of a thick liquid, optionally thixotropic. Examples of such materials are peanut butter, toothpaste, ointments and creams. In this description, both gel and paste terms are used side by side, assuming that the two terms are synonymous one with the other. In the formula, OmX ~, X can be fluoride, chloride, bromide or iodide. Examples of the anion OmX "are the anions hypochlorite, hypoiodite, chlorite, iodite, chlorate, bromate, iodate, perchlorate and periodate. Examples of the anion [Bp0q] r ~, are perborate (B03 ~), metaborate (B02"), orthoborate ( B03 ~), hypoborate (B204"2) and pyroborate or tetraborate anions (B40 2) The preparation according to the invention can be obtained by combining the constituents (a) and (b), the constituents (a) and (b) being combined preferably just before, for example 5 minutes to 1 hour before, or during the use of the preparation. In contrast, it is also possible to prepare the preparation with a longer time in advance, for example 1 hour to 7 days before, in which case, however, it is recommended that the preparation be stored at a low temperature, preferably between 0 ° C and 8 ° C. ° C, until the time in which the preparation is used. The constituents (a) and (b) may also optionally contain pharmaceutical or chemical compounds or substances, such as perfumes, aromatic substances and flavorings, which are commonly used in dental preparations and products. According to the invention, the preparation for bleaching the teeth or for treating mucous membrane disorders is preferably prepared by combining the constituents (a) and (b), the component (i) being composed of at least one An + cation and a 0mX anion ", where A is lithium, sodium or potassium, n = i, X is a halogen atom and m = 1, and component (ii) is composed of at least one An + cation, and an anion [Bp0q] r ", where A is lithium, sodium or potassium ,, p = l, - q = 2 or 3 and r = l. According to the invention, therefore, a hypohalite is used as component (i) and a borate as component (ii). Examples of a hypohalite are lithium hypochlorite, sodium hypochlorite, sodium hypoiodite, and potassium hypochlorite. Examples of suitable borates are the perborates and metaborates of sodium, potassium and lithium. According to the invention, A is in particular sodium and X is chloride and q = 3 and r = l. Therefore, according to the invention component (i) is preferably a hypochlorite, in particular sodium hypochlorite and component (ii) is a perborate, in particular sodium perborate. Component (i) may contain one or more water molecules as water of crystallization. Preferably an aqueous solution. Preferably an aqueous solution of component (i) is used, for example a solution of sodium hypochlorite in water. Such a solution is also called "bleaching water". Component (ii) may also contain one or more water molecules such as water of crystallization, such as sodium perborate trihydrate and sodium perborate tetrahydrate. According to the invention, all hydrates of both component (i) and component (ii) can be used and, therefore, all these hydrates fall within the scope of the invention. Advantageously, the constituents (a) and (b) also contain one or more additives, preferably the additives are one or more of the following components: (iii) a binder; (iv) a gelatinous thickener, - and (v) an agent that counteracts the loss of moisture.

Suitable binders are glycerol, propylene glycol, and certain gums; for example: acacia gum; gum arabic; carayá gum; targacanto gum; , and xanthan gum. According to the invention, the component iii is in particular glycerol. Suitable gelatinous thickeners are cellulose materials, for example, cellulose, or sodium carboxymethyl cellulose, hydroxypropylcellulose, methylcellulose and ethylcellulose. In accordance with the invention, the component (iv) is in particular sodium carboxymethylcellulose. Suitable agents that counteract moisture loss are alditols, for example, erythritol, arabinitol, xylitol, galactitol, sorbitol, iditol, mannitol, heptitol and octitol. According to the invention, the component (v) is in particular sorbitol. According to the invention, the sequence in which the components (i) - (v) are combined is important, in order to obtain the preparation in the form of a homogeneous gel or paste. According to the invention it is therefore important that the homogeneous constituents (a) and (b) are prepared. The constituent (a) is preferably prepared according to the following steps: 1. mixing component (iii) and component (iv); 2. mixing the mixture obtained in step 1 with the component (v); and 3. mixing the mixture obtained in step 2 with component (i). The constituent (b) is preferably prepared according to the following steps: 1. mixing the component (iii) and the component (iv); 2. mixing the mixture obtained in step 1 with the component (v); and 3. mixing the mixture obtained in step 2 with component (ii). According to the invention, it is also possible to use other inorganic compounds which have a whitening action instead of component (ii). Examples of the components are sodium percarbonate, sodium chlorite, sodium carbonate peroxyhydrate and sodium pyrophosphate peroxyhydrate. DETAILED DESCRIPTION OF THE INVENTION The preparation is preferably prepared from a constituent (a), which comprises at least 0.1% to 95% by weight, preferably 1 to 50% by weight, of component (i) and from a constituent (b) which comprises at least 0.1 to 95% by weight, preferably 1 to 50% by weight of component (ii). More preferably, the mixture is prepared from a constituent (a) which comprises at least 0.1 to 95% by weight, preferably 1 to 50% by weight of component (i); from 0.1 to 95% by weight, preferably from 1 to 50% by weight of component (iii); from 0.01 to 20% by weight, preferably from 1 to 10% by weight of component (iv); from 0.1 to 95% by weight, preferably from 1 to 50% by weight of the component (v), and a constituent (b) which comprises at least 0.1 to 95% by weight, preferably 1 to 50% by weight of the component (ii); from 0.1 to 95% by weight, preferably from 1 to 50% by weight of component (iii); from 0.01 to 20% by weight, preferably from 1 to 10% by weight of component (iv), and from 0.1 to 95% by weight, preferably from 1 to 50% by weight of component (v). In particular, the mixture is prepared from a constituent (a) which comprises at least 0.1 to 95% by weight, preferably 1 to 50% by weight of component (i); from 0.1 to 95% by weight, preferably from 1 to 50% by weight of component (iii); from 0.01 to 20% by weight, preferably from 0.1 to 10% by weight of component (iv); and from 0.1 to 95% by weight, preferably from 1 to 50% by weight of component (v), and optionally from 0.1 to 20% by weight, preferably 1 to 15% by weight of sodium citrate; 0.01 to 5% by weight, preferably 0.1 to 4% by weight of sodium fluoride, and a constituent (b) comprising at least 0.1 to 95% by weight, preferably 1 to 50% by weight of the component (ii) ), - from 0.1 to 95% by weight, preferably from 1 to 50% by weight of the component (-iii); from 0.01 to 20% by weight, preferably from 0.1 to 10% by weight of the component (iv) and from 0.1 to 95% by weight, preferably from 1 to 50% by weight of the component (v); and optionally from 0.1 to 50% by weight, preferably from 1 to 20% by weight of sodium citrate; from 0.1 to 50% by weight, preferably from 1 to 20% by weight of magnesium sulfate and from 0.1 to 50% by weight, preferably 1 to 20% by weight of sodium sulfate. A very particular embodiment of the present invention relates to a preparation of the composition indicated above, wherein component (iii) is glycerol, component (iv) is sodium carboxymethylcellulose, and component (v) is sorbitol. If desired, the constituent (a) and the constituent (b) can also comprise other chemical or pharmaceutical substances, for example, perfumes, aromatic substances and flavorings such as those which are generally used in dental products such as toothpastes, by example aspartame. The particle size of the compounds in solid form is not critical, but these compounds are simpler to process to give a homogeneous gel or paste if they are in finely divided form. An average particle size of 0.0001 to 1 mm, in particular 0.01 to 0.1 mm, is suitable. During the mixing of the aforementioned constituents, the mixture of the constituents can be briefly heated to a temperature of 50 to 150 ° C, preferably not higher than 100 ° C, in order to obtain homogeneous pastes or gels. The constituent (b) may also contain other inorganic compounds having a bleaching action, for example sodium percarbonate, sodium chlorite, sodium carbonate peroxyhydrate and sodium pyrophosphate peroxyhydrate, in addition to component (ii) or as a replacement for the component (ii). Preferably, said compound is used in an amount of 0.1 to 50% by weight, preferably 1 to 20% by weight, and in particular in an amount of 5 to 10% by weight. If the constituent (b) contains a compound other than component (ii), such as sodium percarbonate, a constituent (b) of this type was found to be more aggressive than when the constituent (b) contains the component (ii). Therefore, the constituent (b) containing only the component (ii) is preferably used. The preparation that is obtained by the method according to the present invention can be used on the one hand for the bleaching of teeth and on the other hand for the treatment of skin lesions and disorders of the mucous membrane. The bleaching of live teeth can be done as follows. First, a cap or cover is made which has a shape that is complemented by the visible part of the tooth to be bleached. In this context, it is understood that a complementary form is a form by which the internal side faces of the shape are essentially or completely identical to the faces of the external side of the tooth to be bleached and spatially assume precisely the same position that, in such a way that when the bushing or cover is fitted on the tooth a contact assembly is obtained, the space or interval being between the inner side of the bushing or cover and the tooth of approximately 0.01-5 mm, preferably 0.1 - 1 mm, and the cap or cap isolates essentially or completely at least the visible part of the tooth to be bleached from its surroundings. In this context the isolation obtained is such that the preparation is not capable or is hardly able to pass freely in the oral cavity. The preparation is then applied to the inner side of the cap or cover, after the cap or cover is filled with the preparation being placed on the inner side of the teeth. The cap or cover is then held in place for at least 6 hours, preferably 9 hours. At the end of this period, the cover is removed and the mouth is thoroughly rinsed several times with copious amounts of water. The teeth are then cleaned thoroughly by brushing and by using floss and / or toothpicks and / or toothbrush. The method for cleaning a living tooth then comprises the following steps: I) the production of a cover in a form that is complementary to at least the visible part of the tooth to be bleached; II) the application of the preparation to the inner side of the cover; III) placement of the cover, the preparation having been applied to the inner side of the cover, on the external part of a tooth, the cover remaining in place for at least 6 hours, preferably 9 hours; and IV) remove the tooth cover. It will be clear to a person skilled in the art that the method described above can also be carried out in the following manner: I) production of a cover in a form in which it is complementary to that of the visible part of the tooth that goes to be bleached; II) application of the preparation to the external side of the tooth to be bleached; III) placement of the cover on the external side of the tooth, it being possible for a quantity of the preparation to be applied to the inner side of the cover, if desired, and leaving the cover in place for at least 9 hours, - and IV ) remove the tooth cover. It will be clear to a person skilled in the art that if the preparation has been applied to the tooth to be bleached it will not be necessary or would not be necessary in all cases to apply a quantity of the preparation to the inner side of the cap or cover. However, both methods described above can be used to obtain the desired result and are therefore also considered part of the invention. If additional bleaching of the tooth or teeth is desired, the method can be repeated without this an increase in adverse effects. Even in the case of this vital blanching, the bleached tooth under normal circumstances retains the color that has been obtained by bleaching, for a long to very long period of time. The bushing or cover that is used in the methods described above, are produced from a material which is deformable after heating, such as thermoplastic materials. Preferably a material is used, for example a non-toxic polysiloxane, which can be brought to the desired shape after the material has been immersed in hot water for some time. Materials of this type are known in the prior art and are widely used for the production of for example gum protectors, which are often worn when a sport is played. The shape of this cover is such that it is adjusted or can be adjusted so that the cover essentially isolates and completely the visible part of the tooth to be bleached from its surroundings. It can be seen by means of an electron micrograph of the teeth that have been treated on the external part with the preparation according to the invention, that the preparation has no harmful effects on the enamel of the treated tooth. Moreover, it has been found that the preparation has no harmful effects on the gums, but that the virucidal and bactericidal action of the preparation has a beneficial effect on the gums. According to the present invention, the preparation as described above can also be used for the specific treatment of skin diseases and conditions of the mucous membrane, in particular lesions. From what is known, there are no commercially available drugs that are completely effective for injuries such as those caused by the herpes simplex virus. Surprisingly, however, it has been found that the preparation of the present invention effects a complete cure of lesions caused by simple herpes. For this purpose, for example, a mixture of equal parts of the constituent (a) and the constituent (b), are applied approximately five times a day to the lesions. In the case of incipient herpes simplex lesions, it has been found that these lesions have disappeared after 5 days, whereas when the lesions are more than three days old, the lesions have started to disappear after about two days. After healing, there are no visible scars. The additional effects of the preparation in question are those of injuries that do not extend, or they extend little, and resort less frequently. In the case of aphthae (white ulcers) in the mouth it has also been found that the mixture of equal parts of the constituent (a) and constituents (b), for example, has a sanitation effect. For example, when the mixture of equal parts of constituents (a) and the constituent (b) is applied to the canker about six times a day complete sanitation takes place after two days, without the formation of visible scars. Complete sanitation can also be achieved without the formation of scars in the case of a skin condition such as acne, when, for example, the equal mixture of the constituent (a) and the constituent (b) is applied around the skin. five times to the areas to be treated. Furthermore, for example, it has been found that the mixture of equal parts of the constituent (a) and the constituent (b) have an effective sanitation action on fungi of the skin and mucous membrane and on warts. The preparation according to the invention can therefore be used in the treatment of simple herpes lesions, canker sores, acne, exemas, fungi on the skin or mucous membrane, warts, cuts at the corners of the mouth and lips, varicella or other lesions of microbial origin. For the bleaching of non-living teeth, a constituent (a) comprising the component (i) and a constituent (b) comprising the component (ii) is applied alternately and layer by layer in a cavity and in a tooth. The constituent (b) comprising the component (ii) is prepared by a slightly wetting component (ii). The constituent (a) comprising the component (i) is prepared by dissolving the component (i) in water. Since both constituents are applied individually and layer by layer and the preparation comprising component (i) is slightly wetted, the bleaching agent which is obtained by the combination of the two constituents is applied with a delayed action. To whiten a non-living tooth, restoration work on the tooth to be treated is removed first. The cavity thus obtained is then subjected to a number of cleaning or pre-treatment steps, such as those which are normally carried out before a restoration material is applied to a tooth. The constituent (a), which comprises the component (i), and the constituent (b), which comprises the component (ii), are then applied in the cavity, individually and layer by layer. Finally, means are applied so that the cavity is isolated from its surroundings. The method for bleaching a non-living tooth comprises the following steps: a) treatment of a cavity in a tooth with an attack solution, b) treatment of the cavity with a cleaning agent, c) application of at least one layer of a tooth. constituent comprising component (i) and at least one layer of a constituent comprising component (ii), individually and layer by layer and d) application of means that isolate the cavity from its surroundings. The method described above can be used on one or more teeth at the same time. When the preparation is used according to the method described above on one or more teeth at the same time, the bleaching action is completed in 3-6 weeks. If a greater whitening of the tooth or teeth is desired, the method can be repeated without this of an elevation of the adverse effects. Under normal circumstances, the bleached tooth retains, for a long period to a very long period, the color that has been obtained by bleaching. The preparation according to the invention can also be used in veterinary medicine and in industrial bleaching processes, for example, in the paper bleaching process. The preparation according to the invention can also be used in an antimicrobial toothpaste, in which case the component (i) and the component (ii) are present in low concentrations, for example 5% by weight. Said toothpaste then has both antimicrobial action and a whitening or coloring strengthening action. According to the invention, the preparation can also be used in aerosol, bandages, dermatological shampoos, soaps, ointments and gels. The present invention also relates to a reaction product or reaction products for the bleaching of teeth and for the treatment of skin diseases and disorders of the mucous membrane, in particular lesions, whose product (s) is / are obtained (s) by combining component (i) and component (ii). The surprisingly good and long-lasting bleaching effect of a preferred preparation according to the invention is caused by a synergistic effect between component (i) and component (ii). It has been found that the use of either component (i) or component (ii) itself results in little or no bleaching of the treated tooth and that said compounds can not be effectively employed in themselves for the treatment of injuries In contrast, the use of the combination of component (i) and component (ii) according to the methods of the invention has a bleaching effect which is better and more durable than what could be expected based on the results obtained by using the individual compounds. This shows that the two components intensify the effects of one another in a surprising way. Although the nature of this synergistic effect described above is not known, it is assumed, without wanting to be bound or restricted to any specific theory, that the complex chemistry of perborates (or peroxiborates) is responsible for this. The properties of these compounds are described in detail in Gmelin "Handbuch der Anorganischen Chemie", Volume 28, Part 7 (1975), p. 221-237. Thus, it is known that the structure of sodium perborate tetrahydrate can be better described by the formula NaB02.H202.3H20 than by the formula commonly used NaB03.4H20. On the other hand, the crystal structure of sodium perborate tetrahydrate shows that the compound consists of dinuclear anions, the boron ions being bound by two peroxide bridges (M.A. Carrondo, A.C. Skapsi, Acta Cryst, B34 (1978) 3551).

In this case, a better formula would be Na2 [(HO) 2B (0) 2B (OH) 2] .6H20. Raman spectrophotometry in aqueous solutions of sodium perborate tetrahydrate has revealed that the following equilibria are probably established (C.J. Adams and I.E. Clark in Polyhedron 2 (1983) 673-675): 2Na * + [(H0) 2B (02) B (0H) -? 2Na + + [B (0H) 4] '+ H202 [B (H0) 4] "+ H20c-? B (0H) 3 (OOH)" + H20 The position of these equilibria has been found to be highly dependent on the pH prevails Moreover, in concentrated solutions [B (H0) 4] "it can further react to give polybouroids, as a result of which the description of these equilibria is appreciably more complex, however, it has been found that H202 has a very moderate effect and it only has a short-time action for the uses mentioned here, since the preparation according to the invention specifically has an excellent and also long-lasting effect it can be seen from this that the effect is not based or caused by the formation of H202. knows that, depending on the conditions, sodium perborate tetrahydrate is decomposed into sodium tetraborate Na2B407 and oxygen (Gmelin "Handbuch der Anorganischen Chemie" volume 28, part 7 (1975), PP 221-237). conditions that prevail in the tooth (non-living treatment) or in the oral cavity (living treatment) are unknown, it is assumed that oxygen is an active constituent of the bleaching agent. it has been found that when the preparation according to the invention is used in the oral cavity, the patient does not experience the known sensation of discomfort or burning that is caused by H202. This could be explained by the very slow or delayed formation of H202 and / or the formation of H202 in very small amounts, which is plausible since the preparation according to the invention contains only a very small amount of water. According to Kirk-Othmer, "Encyclopedia of Chemical Technology ", part 13 (1981), page 15, H202 is able to relatively reduce the power of oxidizing agents such as hypochlorite, since the preparation according to the invention, for example, may contain sodium hypochlorite , the latter in such case, then it would be reduced to chloride and hidoxyl anions, the hydrogen peroxide decomposing to form oxygen and water.Therefore it seems that the bleaching action of the preparation according to the invention is essentially caused by oxygen. The surprisingly good and lasting effect of the preparation according to the invention thus seems not to fall into a combination of the normal bleaching mechanisms of components (i) and (ii), respectively, although it has not been established that these The whitening action of component (ii), such as, for example, sodium tetraborate, usually takes place through the epoxidation of unsaturated carbon-carbon bonds. Thus, it is then assumed that the whitening action of component (i), such as, for example, sodium hypochlorite, normally takes place through the known hypohalite reaction, in which the addition of, for example, H0C1 takes place. to the unsaturated carbon-carbon bond, in the case of the addition of HOC1, chlorohydrin is formed. However, it seems more likely that oxygen plays a significant role in the bleaching action of the preparation of the present invention, although a contribution of other compounds, mentioned above, to the bleaching action is not excluded.

The invention is explained in more detail below with the aid of the two examples of a method for live and non-living banqueting of teeth, respectively, an example of a method for treating lesions caused by the herpes simplex virus and several examples that provide the methods of preparation of dental and cosmetic products containing the preparation of this invention. Example I This example describes a method for bleaching a non-living tooth. First an X-ray photograph is taken to establish whether the tooth to be bleached has been subjected to endodontic treatment. An assessment must be made of whether the channel was properly closed or not, at least insofar as it can be assessed from the picture. If this is not the case, at this point a endodontic treatment is carried out. The palate or occlusal filling, which is present in the cavity of the pulp and part of the filling of the canal are then removed successively. A measurement is taken using a cavity measuring needle to determine if the canal filling has been removed at least 2mm below the level of the buccal gum. Using, for example, using a thin endodontic file, a check is carried out to determine if the channel fill is sealing the root canal properly. The enamel and the internal dentin of the hollow prepared in the tooth is attacked with acid for 10-60 seconds with 37% orthophosphoric acid, after which the hole is rinsed for 10 seconds with water, in order to remove the attack solution. The dentin inside the tooth is then treated for 10 - 60 seconds with a solution of 20% EDTA in water, then the hole is once again rinsed for 10 seconds with water. The tooth is then air dried. The bleaching agent is applied in layers in the following manner. A layer of a sodium perborate and water preparation is first applied at the deepest point of the cavity. The powder is compressed a little with the help of a ball of cotton wool. Then take a ball of cotton wool prepared with sodium hypochlorite and water. This wool cotton ball is pushed into the cavity on top of the preparation of sodium perborate and water. These latter stages are repeated several times, such that a layer of the developed bleaching agent is produced. The final layer in the cavity should always be a ball of cotton wool prepared with sodium hypochlorite. The cavity is then sealed by performing temporary restoration work. This temporary restoration must be completed in terms of occlusion and articulation. Example II This example describes a method for bleaching a living tooth. The two constituents (a) and (b) having the following composition are prepared: Constituent (a): 5 ml of sodium hypochlorite in 4% water. 2 mg of sodium citrate. 4 mg of sodium fluoride (0.4% solution in water) 4 mg of carboxymethylcellulose. 2.5 ml of glycerol. 2.5 ml of sorbitol in 70% water. Constituent (b): 3 g of sodium perborate tetrahydrate. 2 mg of sodium citrate. 4 mg of sodium carboxymethylcellulose 5 ml of glycerol 5 ml of sorbitol in 70% water. 2 mg of magnesium sulfate or sodium sulfate. The constituents (a) and (b) are preferably mixed as follows. It is first mixed with glycerol and sodium carboxymethylcellulose and the sorbitol is then mixed therein. The other components can then be added in any order. If desired, the entire mixture can be briefly heated to about 100 ° C during mixing, as a result of which more homogeneous mixtures are obtained. To simplify the process, the two constituents (a) and (b) can be inserted into a double syringe call. Before the bleaching treatment, the tooth is perfectly cleaned by brushing and by using floss and / or toothpicks and / or toothbrushes. The preparation is then prepared by placing equal amounts of the constituents (a) and (b) in a mixing vessel, after which the two constituents are mixed for 10 seconds with the help of a spatula. The mixture obtained is applied to the inner part of a silicone sleeve, which has previously been made to a size such that the side of the cheek of the tooth or teeth to be bleached, is brought into contact with the Preparation when the silicone hose is adjusted over the tooth. The preparation is removed in excess. The silicone sleeve should preferably remain in place for at least 8 hours. Subsequently, the silicone hose is removed and the mouth is thoroughly rinsed several times with copious amounts of water. As a final stage, the tooth is then perfectly cleaned once more, by brushing and by using floss and / or toothpicks and / or toothbrushes. EXAMPLE III A preparation is prepared which contains equal amounts of the constituent (a) and the constituent (b). The preparation is applied, spreading it to the affected tissues of a patient suffering from incipient lesions of herpes simplex. The application is repeated approximately four times a day. The affected tissue is completely healed within five days, whereas the lesions usually disappear only after 2-3 weeks. The same results have been obtained with preparations containing constituents (a) and constituents (b) in averages of 10: 1 to 1:10. EXAMPLE IV Antimicrobial toothpastes were peparated in the following manner. First a preparation was prepared which contains equal amounts of constituents (a) and constituents (b). Subsequently, the antimicrobial toothpastes were prepared, containing 0.1% to 50% by weight of the preparation, and 50 to 99% by weight of the compositions used in the toothpaste, the compositions containing the usual constituents such as glycerol, water, silica xerogel, sodium lauryl sulfate, hydroxyethylcellulose, sorbitol, sodium fluoride fluoride and dyes. Example V The dermatological shampoos were prepared as follows. A preparation containing equal amounts of constituent (a) and constituent (b) was prepared first. Subsequently, dermatological shampoo containing 0.1 to 75% by weight of the preparation and 25 to 99.9% by weight of the compositions used in shampoos was prepared, the compositions containing the usual constituents such as sodium lauryl sulfate, lauryl alcohol, sodium chloride, a alkanolamino of a fatty acid, EDTA, a conditioner and an anti-dandruff agent. EXAMPLE VI Sprayed bandages were prepared as follows: A preparation containing equal amounts of constituent (a) and constituent (b) was first prepared. Subsequently, sprayed bandages containing 0.1 to 75% by weight of the preparation and 25 to 99.9% by weight of the compositions used in sprayed dressings were prepared, the compositions containing the usual constituents such as acrylate, and / or methacrylate, a solvent such as acetone, ethanol, or ethyl acetate, cellulose derivatives, a propellant such as pentane and / or butane and optionally one or more antibiotics or antiseptics. Example VII A dermatological soap was prepared as follows: A preparation containing equal amounts of constituent (a) and constituent (b) was first prepared. Subsequently, the dermatological soap containing 0.1 to 75% by weight of the preparation and 25 to 99.9% by weight of the compositions used in the soaps was prepared, the compositions containing the usual constituents such as sodium laurylethyl sulfate, as used in mild soaps. or soaps based on solid or liquid fatty acids.

Claims (14)

1. NOVELTY OF THE INVENTION Having described the present invention it is considered as a novelty and therefore the content of the following is claimed as property: CLAIMS 1. A preparation of a combination for whitening the teeth or for the treatment of skin lesions and disorders of the mucous membranes comprising at least: (a) a gel or paste in which a component (i) is present, the component (i) consisting of at least one An + cation and one "OmX" anion, wherein A it is a metal of group 1 or 2 of the periodic table; n = 1 or 2, - X is a halogen and m = 1-4; and (b) a gel or paste in which a component (ii) is present, the component (ii) consisting of at least one An + cation and one anion [BpOq] r ", wherein A is a group 1 metal or 2 of the periodic table, p = 1-4, q = 1-8 and r = 1-3 2. A preparation according to claim 1, characterized in that A is lithium, sodium or potassium, n = m = p = l; q = 2 or 3 and r = l-3 3. A preparation according to claim 1 or 2, characterized in that A is sodium and X is chlorine and q = 3 and r = 1. 4. A preparation according to claims 1 to 3, characterized in that (a) and (b) also contain one or more of the following components: (iii) a binder, - (iv) a gelatinous thickener, (v) an agent that counteracts moisture loss. claim 4, characterized in that component (iii) is glycerol, glycol, propylene glycol, or a gum, component (iv) is a cellulose material and component (v) is an alditol. as claim 4 or 5, characterized in that the component (iii) is glycerol; component (iv) is sodium carboxymethylcellulose and component (v) is sorbitol. 7. A preparation according to claims 4 to 6, characterized in that (a) is prepared according to the following steps: (1) mixing the component (iii) and the component (iv); (2) mixing the mixture obtained in step (1) with component (v), - and (3) mixing the mixture obtained in step (2) with component (i). 8. A preparation according to claims 4 to 7, characterized in that (b) is prepared according to the following steps: (1) mixing component (iii) with component (iv), - (2) mixing the mixture obtained in step (1) with component (v), - and (3) mixing the mixture obtained in step (2) with component (ii). 9. A preparation according to claims 1 to 8, characterized in that (a) it contains from 5 to 95% by weight, preferably from 1 to 50% by weight of component (i), - and (b) contains from 5 to 95% by weight, preferably from 1 to 50% by weight of component (ii). 10. A preparation according to claims 1 to 9, characterized in that it is used as an active substance for the bleaching of teeth or for the treatment of skin lesions and disorders of the mucous membrane. 11. A preparation according to claim 10, characterized in that it is used as an active substance for bleaching live teeth. 12. A preparation according to claim 10, characterized in that it is used as an active substance for the treatment of injuries. 13. A preparation according to claim 10, characterized in that lesions caused by simple herpes, aphthae, acne, eczema, fungi on the skin or mucous membrane, warts, cuts at the corners of the mouth and in the mouth are used as the active substance for the treatment. lips, chicken pox or other lesions of microbial origin. 14. The use of the preparation according to any of claims 1 to 9 for the preparation of antimicrobial pastes, sprayed bandages, dermatological shampoos, soaps, ointments and gels.